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El
Maatougui, Abdelaziz; Azuaje, Jhonny; González-Gómez, Manuel; Miguez, Gabriel; Crespo, Abel; Carbajales, Carlos; Escalante, Luz; García-Mera, Xerardo; Gutiérrez-de-Terán, Hugo; Sotelo, Eddy (2016-03-10).
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Tay, Apple Hui Min; Prieto-Díaz, Rubén; Neo, Shiyong; Tong, Le; Chen, Xinsong; Carannante, Valentina; Önfelt, Björn; Hartman, Johan; Haglund, Felix; Majellaro, Maria; Azuaje, Jhonny (2022-05-01).
40:(±)-Isopropyl 4-(Furan-2-yl)-2-methyl-1,4-dihydrobenzo-imidazopyrimidine-3-carboxylate, 4-(2-Furanyl)-4,10-dihydro-2-methyl-pyrimidobenzimidazole-3-carboxylic acid 1-methylethyl ester
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InChI=1S/C19H19N3O3/c1-11(2)25-18(23)16-12(3)20-19-21-13-7-4-5-8-14(13)22(19)17(16)15-9-6-10-24-15/h4-11,17H,1-3H3,(H,20,21)
467:"A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models"
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420:"Discovery of Potent and Highly Selective A 2B Adenosine Receptor Antagonist Chemotypes"
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Except where otherwise noted, data are given for materials in their
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and >1000-fold selectivity with respect to the other three
376:. It has been shown to help the immune system to attack
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228:CC1=C(C(N2C3=CC=CC=C3N=C2N1)C4=CC=CO4)C(=O)OC(C)C
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207:Key: NYHLRBMDXQBOIB-UHFFFAOYSA-N
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546:Heterocyclic compounds with 3 rings
471:Journal for ImmunoTherapy of Cancer
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353:. Discovered in 2016, it has a
293:(at 25 °C , 100 kPa).
424:Journal of Medicinal Chemistry
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436:10.1021/acs.jmedchem.5b01586
374:adenosine receptor subtypes
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484:10.1136/jitc-2022-004592
541:Nitrogen heterocycles
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384:assays by rescuing
334:is a selective non-
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362:of 3.49 nM on the
320:Infobox references
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531:2-Furyl compounds
328:Chemical compound
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477:(5): e004592.
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283:White solid
54:Identifiers
46:Other names
280:Appearance
237:Properties
71:932191-62-3
37:IUPAC names
525:Categories
404:References
351:antagonist
271:Molar mass
147:IUPHAR/BPS
126:ChemSpider
82:3D model (
61:CAS Number
493:2051-1426
444:0022-2623
380:cells in
339:adenosine
336:xanthinic
17:ISAM-140
511:35580926
452:26824742
394:cytokine
382:in vitro
370:receptor
348:receptor
332:ISAM-140
182:17198004
135:12904393
502:9115112
313:what is
311: (
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169:PubChem
48:ISAM140
536:Esters
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378:cancer
308:verify
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221:SMILES
106:ChEMBL
31:Names
196:InChI
157:11223
84:JSmol
507:PMID
489:ISSN
448:PMID
440:ISSN
388:and
497:PMC
479:doi
432:doi
398:TIL
172:CID
527::
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390:NK
366:2B
344:2B
255:19
251:19
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481::
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386:T
364:A
358:i
355:K
342:A
303:N
263:3
261:O
259:3
257:N
253:H
249:C
86:)
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