253:
230:
127:
152:
504:
511:
259:
158:
2275:
1077:
interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all the variants have been fully characterized. Additionally, it has been shown to interact with RhoGDI1 to
1078:
alter the activation of Rho GTPases to promote
Glioblastoma cell invasiveness. Uncoupling the αvβ8-RhoGDI1 interaction has been seen to block GBM cell invasion by hyperactivating Rho GTPases.
1069:
beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a
266:
165:
1822:
2255:
784:
1382:
Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM (1997). "Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo".
88:
765:
2122:
1782:"Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation"
2349:
1446:
Cambier S, Mu DZ, O'Connell D, et al. (2001). "A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth".
1174:
2320:
1694:"Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue"
1156:
2339:
252:
1860:
991:
984:
229:
1735:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1195:
1143:
1122:
1139:
151:
126:
1512:"Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis"
1118:
68:
1829:
265:
164:
1349:"Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain"
258:
157:
2313:
1211:"αvβ8 Integrin Interacts with RhoGDI1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion"
829:
76:
1853:
810:
2217:
2191:
2186:
2181:
2106:
2096:
2037:
2042:
1260:"Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by {beta}8 Integrin"
1209:
Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH (January 2012).
1097:
tumors. Conversely low expression of ITGB8 correlates with highly invasive but low angiogenic tumors.
2306:
2154:
2138:
2069:
1744:
1662:
1611:
1558:
1074:
140:
55:
1469:"The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1"
2344:
1846:
1768:
100:
1547:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
967:
946:
920:
899:
1803:
1760:
1723:
1680:
1637:
1586:
1533:
1498:
1455:
1434:
1399:
1370:
1335:
1289:
1240:
503:
48:
2290:
2143:
2074:
2004:
1999:
1953:
1793:
1752:
1713:
1705:
1670:
1627:
1619:
1576:
1566:
1523:
1488:
1480:
1424:
1391:
1360:
1325:
1279:
1271:
1230:
1222:
345:
276:
220:
175:
510:
96:
1833:
320:
1748:
1666:
1615:
1562:
2238:
2233:
2212:
1718:
1693:
1632:
1599:
1493:
1468:
1284:
1259:
1235:
1210:
1709:
1581:
1546:
1365:
1348:
1330:
1313:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
618:
613:
608:
603:
598:
593:
588:
583:
567:
562:
557:
552:
2333:
1070:
539:
1395:
80:
2286:
1772:
1094:
1087:
338:
117:
1275:
104:
1179:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1161:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1411:
Sanger Centre, The; Washington
University Genome Sequencing Cente, The (1999).
1258:
Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH (October 2011).
421:
1091:
237:
134:
84:
1623:
1226:
1073:
integrin complex. In general, integrin complexes mediate cell-cell and cell-
729:
481:
359:
304:
291:
203:
190:
92:
1826:
1807:
1798:
1781:
1764:
1727:
1684:
1641:
1590:
1571:
1537:
1528:
1511:
1502:
1459:
1293:
1244:
1484:
1438:
1403:
1374:
1339:
1031:
1026:
1869:
1429:
1412:
1066:
1015:
874:
855:
1756:
1675:
1650:
1047:
841:
796:
2047:
1933:
1928:
999:
751:
17:
2274:
2201:
2196:
2159:
2127:
2101:
2014:
2009:
1994:
1963:
1958:
1948:
1943:
1938:
1923:
1918:
1913:
1908:
1903:
1898:
1893:
1888:
1883:
714:
710:
2282:
2205:
2163:
2147:
2131:
2078:
2051:
1989:
1984:
1979:
1054:
72:
1842:
1314:"Cloning and expression of a divergent integrin subunit beta 8"
519:
1692:
Fjellbirkeland L, Cambier S, Broaddus VC, et al. (2003).
1838:
1545:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1086:
High expression levels of ITGB8 are associated with high
1598:
Scherer SW, Cheung J, MacDonald JR, et al. (2003).
700:
regulation of transforming growth factor beta activation
328:
2294:
1467:
Mu D, Cambier S, Fjellbirkeland L, et al. (2002).
1649:
Hillier LW, Fulton RS, Fulton LA, et al. (2003).
493:
2226:
2174:
2115:
2089:
2062:
2030:
2023:
1972:
1876:
960:
939:
913:
892:
1135:
1133:
1131:
1114:
1112:
1110:
275:
174:
27:Protein-coding gene in the species Homo sapiens
1600:"Human Chromosome 7: DNA Sequence and Biology"
1140:GRCm38: Ensembl release 89: ENSMUSG00000025321
2314:
1854:
1510:Jarad G, Wang B, Khan S, et al. (2003).
8:
1347:Nishimura SL, Sheppard D, Pytela R (1994).
1119:GRCh38: Ensembl release 89: ENSG00000105855
2321:
2307:
2027:
1861:
1847:
1839:
725:
535:
316:
215:
112:
1797:
1717:
1674:
1631:
1580:
1570:
1527:
1492:
1428:
1413:"Toward a complete human genome sequence"
1364:
1329:
1283:
1234:
1651:"The DNA sequence of human chromosome 7"
1190:
1188:
1106:
1312:Moyle M, Napier MA, McLean JW (1991).
675:negative regulation of gene expression
660:positive regulation of gene expression
29:
1196:"Entrez Gene: ITGB8 integrin, beta 8"
280:
241:
236:
179:
138:
133:
7:
2271:
2269:
558:extracellular matrix protein binding
695:positive regulation of angiogenesis
635:integrin-mediated signaling pathway
2293:. You can help Knowledge (XXG) by
2256:cell surface receptor deficiencies
957:
936:
910:
889:
865:
846:
820:
801:
775:
756:
690:cell adhesion mediated by integrin
498:
416:
354:
333:
25:
1050:that in humans is encoded by the
665:extracellular matrix organization
645:placenta blood vessel development
2273:
509:
502:
264:
257:
251:
228:
163:
156:
150:
125:
1396:10.1152/ajplung.1997.273.1.L256
589:integral component of membrane
520:More reference expression data
482:More reference expression data
1:
2350:Human chromosome 7 gene stubs
1710:10.1016/S0002-9440(10)63681-4
1366:10.1016/S0021-9258(19)61963-0
1331:10.1016/S0021-9258(18)55042-0
1276:10.1158/0008-5472.CAN-11-0991
1065:This gene is a member of the
655:ganglioside metabolic process
584:integrin alphav-beta8 complex
249:
148:
2116:Leukocyte-adhesion receptor:
1551:Proc. Natl. Acad. Sci. U.S.A
436:Epithelium of choroid plexus
2340:Genes on human chromosome 7
2175:Very late antigen receptor:
568:signaling receptor activity
2366:
2268:
553:signaling receptor binding
432:retinal pigment epithelium
370:retinal pigment epithelium
2251:
1175:"Mouse PubMed Reference:"
1157:"Human PubMed Reference:"
1030:
1025:
1021:
1014:
998:
992:Chr 12: 119.12 – 119.2 Mb
979:
964:
943:
932:
917:
896:
885:
872:
868:
853:
849:
840:
827:
823:
808:
804:
795:
782:
778:
763:
759:
750:
735:
728:
724:
708:
538:
534:
517:
501:
492:
479:
468:medial vestibular nucleus
428:
419:
398:mucosa of paranasal sinus
390:bronchial epithelial cell
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
59:, integrin subunit beta 8
53:
46:
41:
37:
32:
374:external globus pallidus
1825:Info with links in the
1624:10.1126/science.1083423
1227:10.1091/mbc.E12-07-0521
985:Chr 7: 20.33 – 20.42 Mb
440:suprachiasmatic nucleus
1827:Cell Migration Gateway
1799:10.1074/jbc.M601856200
1780:Yan W, Shao R (2006).
1572:10.1073/pnas.242603899
1529:10.1074/jbc.M204901200
444:deep cerebellar nuclei
2227:Vitronectin receptor:
2090:Fibronectin receptor:
2043:Glycoprotein IIb/IIIa
2031:Cytoadhesin receptor:
1485:10.1083/jcb.200109100
1082:Clinical significance
640:cartilage development
609:extracellular exosome
243:Chromosome 12 (mouse)
2218:Integrin alpha6beta1
2192:Integrin alpha3beta1
2187:Integrin alpha2beta1
2182:Integrin alpha1beta1
2155:Integrin alphaXbeta2
2139:Macrophage-1 antigen
2107:Integrin alpha5beta1
2102:Integrin alpha4beta1
2097:Integrin alpha2beta1
2070:Macrophage-1 antigen
2063:Fibrinogen receptor:
2038:Integrin alpha6beta4
1430:10.1101/gr.8.11.1097
1075:extracellular matrix
670:cell-matrix adhesion
141:Chromosome 7 (human)
1757:10.1038/nature04209
1749:2005Natur.437.1173R
1676:10.1038/nature01782
1667:2003Natur.424..157H
1616:2003Sci...300..767S
1563:2002PNAS...9916899M
1390:(1 Pt 1): L256–63.
402:trigeminal ganglion
2281:This article on a
1832:2014-12-11 at the
830:ENSMUSG00000025321
628:Biological process
577:Cellular component
546:Molecular function
448:olfactory tubercle
2302:
2301:
2263:
2262:
2247:
2246:
1557:(26): 16899–903.
1041:
1040:
1037:
1036:
1010:
1009:
975:
974:
954:
953:
928:
927:
907:
906:
881:
880:
862:
861:
836:
835:
817:
816:
791:
790:
772:
771:
720:
719:
530:
529:
526:
525:
488:
487:
475:
474:
413:
412:
394:corpus epididymis
311:
310:
210:
209:
105:ITGB8 - orthologs
16:(Redirected from
2357:
2323:
2316:
2309:
2277:
2270:
2028:
1863:
1856:
1849:
1840:
1811:
1801:
1776:
1743:(7062): 1173–8.
1731:
1721:
1688:
1678:
1661:(6945): 157–64.
1645:
1635:
1610:(5620): 767–72.
1594:
1584:
1574:
1541:
1531:
1522:(49): 47826–33.
1506:
1496:
1463:
1442:
1432:
1423:(11): 1097–108.
1407:
1378:
1368:
1359:(46): 28708–15.
1343:
1333:
1298:
1297:
1287:
1255:
1249:
1248:
1238:
1206:
1200:
1199:
1192:
1183:
1182:
1171:
1165:
1164:
1153:
1147:
1137:
1126:
1116:
1023:
1022:
994:
987:
970:
958:
949:
937:
933:RefSeq (protein)
923:
911:
902:
890:
866:
847:
821:
802:
776:
757:
726:
599:integrin complex
563:integrin binding
536:
522:
513:
506:
499:
484:
456:substantia nigra
424:
422:Top expressed in
417:
406:caput epididymis
378:ventricular zone
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
58:
51:
30:
21:
2365:
2364:
2360:
2359:
2358:
2356:
2355:
2354:
2330:
2329:
2328:
2327:
2266:
2264:
2259:
2243:
2222:
2170:
2111:
2085:
2058:
2019:
1968:
1872:
1867:
1834:Wayback Machine
1819:
1814:
1792:(28): 19700–8.
1779:
1734:
1691:
1648:
1597:
1544:
1509:
1466:
1454:(24): 7084–93.
1445:
1410:
1381:
1346:
1324:(29): 19650–8.
1311:
1307:
1305:Further reading
1302:
1301:
1270:(20): 6371–81.
1257:
1256:
1252:
1208:
1207:
1203:
1194:
1193:
1186:
1173:
1172:
1168:
1155:
1154:
1150:
1138:
1129:
1117:
1108:
1103:
1084:
1063:
1044:Integrin beta-8
1032:View/Edit Mouse
1027:View/Edit Human
990:
983:
980:Location (UCSC)
966:
945:
919:
898:
811:ENSG00000105855
704:
623:
604:plasma membrane
572:
518:
508:
507:
480:
471:
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219:Gene location (
201:
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161:
139:
116:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
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2300:
2299:
2278:
2261:
2260:
2252:
2249:
2248:
2245:
2244:
2242:
2241:
2239:Alpha-v beta-5
2236:
2234:Alpha-v beta-3
2230:
2228:
2224:
2223:
2221:
2220:
2215:
2213:Alpha-5 beta-1
2210:
2209:
2208:
2194:
2189:
2184:
2178:
2176:
2172:
2171:
2169:
2168:
2167:
2166:
2152:
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2136:
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2134:
2119:
2117:
2113:
2112:
2110:
2109:
2104:
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2087:
2086:
2084:
2083:
2082:
2081:
2066:
2064:
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2059:
2057:
2056:
2055:
2054:
2040:
2034:
2032:
2025:
2021:
2020:
2018:
2017:
2012:
2007:
2002:
1997:
1992:
1987:
1982:
1976:
1974:
1970:
1969:
1967:
1966:
1961:
1956:
1951:
1946:
1941:
1936:
1931:
1926:
1921:
1916:
1911:
1906:
1901:
1896:
1891:
1886:
1880:
1878:
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1818:
1817:External links
1815:
1813:
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1507:
1479:(3): 493–507.
1464:
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1408:
1384:Am. J. Physiol
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685:cell migration
682:
680:vasculogenesis
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667:
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642:
637:
631:
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621:
619:focal adhesion
616:
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387:
386:spinal ganglia
383:
382:synovial joint
379:
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371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
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2185:
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2165:
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2158:
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1965:
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1786:J. Biol. Chem
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1707:
1704:(2): 533–42.
1703:
1699:
1698:Am. J. Pathol
1695:
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1516:J. Biol. Chem
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1353:J. Biol. Chem
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1318:J. Biol. Chem
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1254:
1251:
1246:
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1237:
1232:
1228:
1224:
1221:(4): 474–82.
1220:
1216:
1215:Mol Biol Cell
1212:
1205:
1202:
1197:
1191:
1189:
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1176:
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1111:
1107:
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1098:
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1089:
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1079:
1076:
1072:
1071:heterodimeric
1068:
1060:
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1033:
1028:
1024:
1020:
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989:
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938:
935:
931:
924:
922:
916:
912:
909:
903:
901:
895:
891:
888:
886:RefSeq (mRNA)
884:
877:
876:
871:
867:
864:
858:
857:
852:
848:
845:
843:
839:
832:
831:
826:
822:
819:
813:
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781:
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723:
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683:
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678:
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651:
650:cell adhesion
648:
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564:
561:
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556:
554:
551:
550:
548:
545:
544:
541:
540:Gene ontology
537:
533:
521:
516:
512:
505:
500:
497:
495:
491:
483:
478:
467:
463:
460:otolith organ
459:
455:
452:sciatic nerve
451:
447:
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389:
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306:
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297:
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288:
282:12|12 F2
278:
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222:
217:
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205:
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136:
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119:
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90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
2295:expanding it
2287:chromosome 7
2280:
2265:
2253:
1789:
1785:
1740:
1736:
1701:
1697:
1658:
1654:
1607:
1603:
1554:
1550:
1519:
1515:
1476:
1473:J. Cell Biol
1472:
1451:
1447:
1420:
1416:
1387:
1383:
1356:
1352:
1321:
1317:
1267:
1263:
1253:
1218:
1214:
1204:
1178:
1169:
1160:
1151:
1095:glioblastoma
1085:
1064:
1051:
1043:
1042:
965:
944:
918:
897:
873:
854:
828:
809:
783:
764:
744:
739:
594:cell surface
344:
337:
303:119,202,537
290:119,121,757
64:External IDs
1090:and poorly
202:20,415,754
189:20,330,702
42:Identifiers
2334:Categories
1448:Cancer Res
1417:Genome Res
1264:Cancer Res
1146:, May 2017
1125:, May 2017
1101:References
1088:angiogenic
348:(ortholog)
85:HomoloGene
2345:Integrins
2285:on human
2254:see also
1870:Integrins
968:NP_796264
947:NP_002205
921:NM_177290
900:NM_002214
730:Orthologs
93:GeneCards
1830:Archived
1808:16702213
1765:16189514
1728:12875973
1685:12853948
1642:12690205
1591:12477932
1538:12324452
1503:11970960
1460:11156415
1294:21859829
1245:23283986
1142:–
1121:–
1092:invasive
1067:integrin
1061:Function
1016:Wikidata
709:Sources:
614:membrane
1773:4427026
1745:Bibcode
1719:1868219
1663:Bibcode
1633:2882961
1612:Bibcode
1604:Science
1559:Bibcode
1494:2173277
1439:9847074
1404:9252563
1375:7525578
1340:1918072
1285:3193578
1236:3571870
1144:Ensembl
1123:Ensembl
1048:protein
842:UniProt
797:Ensembl
736:Species
715:QuickGO
464:utricle
323:pattern
81:1338035
49:Aliases
2048:ITGA2B
2024:Dimers
1806:
1771:
1763:
1737:Nature
1726:
1716:
1683:
1655:Nature
1640:
1630:
1589:
1582:139241
1579:
1536:
1501:
1491:
1458:
1437:
1402:
1373:
1338:
1292:
1282:
1243:
1233:
1002:search
1000:PubMed
875:Q0VBD0
856:P26012
785:320910
752:Entrez
494:BioGPS
181:7p21.1
73:604160
2289:is a
2202:CD49d
2197:VLA-4
2160:CD11c
2144:CD11b
2128:CD11a
2123:LFA-1
2075:CD11b
2052:ITGB3
1877:Alpha
1823:ITGB8
1769:S2CID
1052:ITGB8
1046:is a
745:Mouse
740:Human
711:Amigo
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
97:ITGB8
89:18567
56:ITGB8
33:ITGB8
18:ITGB8
2291:stub
2283:gene
2206:CD29
2164:CD18
2148:CD18
2132:CD18
2079:CD18
1973:Beta
1804:PMID
1761:PMID
1724:PMID
1681:PMID
1638:PMID
1587:PMID
1534:PMID
1499:PMID
1456:PMID
1435:PMID
1400:PMID
1371:PMID
1336:PMID
1290:PMID
1241:PMID
1055:gene
766:3696
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
69:OMIM
1934:A11
1929:A10
1794:doi
1790:281
1753:doi
1741:437
1714:PMC
1706:doi
1702:163
1671:doi
1659:424
1628:PMC
1620:doi
1608:300
1577:PMC
1567:doi
1524:doi
1520:277
1489:PMC
1481:doi
1477:157
1425:doi
1392:doi
1388:273
1361:doi
1357:269
1326:doi
1322:266
1280:PMC
1272:doi
1231:PMC
1223:doi
299:End
198:End
101:OMA
77:MGI
2336::
2015:B8
2010:B7
2005:B6
2000:B5
1995:B4
1990:B3
1985:B2
1980:B1
1964:AX
1959:AV
1954:AM
1949:AL
1944:AE
1939:AD
1924:A9
1919:A8
1914:A7
1909:A6
1904:A5
1899:A4
1894:A3
1889:A2
1884:A1
1802:.
1788:.
1784:.
1767:.
1759:.
1751:.
1739:.
1722:.
1712:.
1700:.
1696:.
1679:.
1669:.
1657:.
1653:.
1636:.
1626:.
1618:.
1606:.
1602:.
1585:.
1575:.
1565:.
1555:99
1553:.
1549:.
1532:.
1518:.
1514:.
1497:.
1487:.
1475:.
1471:.
1452:60
1450:.
1433:.
1419:.
1415:.
1398:.
1386:.
1369:.
1355:.
1351:.
1334:.
1320:.
1316:.
1288:.
1278:.
1268:71
1266:.
1262:.
1239:.
1229:.
1219:24
1217:.
1213:.
1187:^
1177:.
1159:.
1130:^
1109:^
1057:.
713:/
305:bp
292:bp
204:bp
191:bp
99:;
95::
91:;
87::
83:;
79::
75:;
71::
2322:e
2315:t
2308:v
2297:.
2204:+
2162:+
2146:+
2130:+
2077:+
2050:+
1862:e
1855:t
1848:v
1810:.
1796::
1775:.
1755::
1747::
1730:.
1708::
1687:.
1673::
1665::
1644:.
1622::
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1593:.
1569::
1561::
1540:.
1526::
1505:.
1483::
1462:.
1441:.
1427::
1421:8
1406:.
1394::
1377:.
1363::
1342:.
1328::
1296:.
1274::
1247:.
1225::
1198:.
1181:.
1163:.
223:)
120:)
103::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
