321:
298:
195:
220:
327:
226:
1566:
1097:
Studies have shown that male Izumo knockout mice are sterile because their sperm are unable to fuse to the oocyte membrane. Izumo -/- mice produced morphologically normal sperm that were able to penetrate the zona pellucida, but could not fuse with to the eggs. In fact, it is necessary to relocate
50:
1105:
analyses, it has been shown that Izumo is only expressed in the testis and is found on mature spermatozoa. Izumo-1 located on mature spermatozoa that have undergone capacitation binds to its receptor Juno, which is located on the oolemma of eggs.
1283:
Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Molecular reproduction and development. 2009;76(12):1188-1199.
1274:
Ikawa, M., Inoue, N., Benham, A. M., & Okabe, M. (2010). Fertilization: a sperm's journey to and interaction with the oocyte. The
Journal of clinical investigation, 120(4), 984-94.
1292:
Bianchi E, Doe B, Goulding D, Sanger Mouse
Genetics Project, Wright GJ. Juno is the egg Izumo receptor and is essential for mammalian fertilisation. Nature. 2014;508(7497):483-487.
1307:
Chu AY, Workalemahu T, Paynter NP, Rose LM, Giulianini F, Tanaka T, Ngwa JS, Qi Q, Curhan GC, Rimm EB, Hunter DJ, Pasquale LR, Ridker PM, Hu FB, Chasman DI, Qi L (2013).
334:
233:
1098:
the IZUMO1 to the site of oocyte fusion. In-vitro human experiments have also been conducted, suggesting that Izumo is required for human gamete fusion.
1546:
762:
781:
156:
1635:
1354:"Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization"
1611:
1165:
1630:
1183:
320:
997:
1224:
Inoue N, Ikawa M, Isotani A, Okabe M (2005). "The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs".
1004:
1214:
Bianchi, Enrica, et al. "Juno is the egg Izumo receptor and is essential for mammalian fertilization." Nature 508.7497 (2014): 483.
297:
1152:
1131:
219:
194:
1148:
47:
1127:
136:
333:
232:
1604:
326:
225:
1313:
826:
144:
807:
1597:
208:
1233:
123:
980:
955:
951:
925:
904:
900:
1257:
168:
959:
896:
1531:
1498:
1453:
1424:"Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm"
1410:
1375:
1340:
1249:
116:
40:
1581:
1523:
1488:
1478:
1443:
1435:
1400:
1389:"Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure"
1365:
1330:
1322:
1241:
413:
344:
288:
243:
164:
388:
1237:
1493:
1466:
1448:
1423:
1335:
1308:
1075:
1387:
Granados-Gonzalez V, Aknin-Seifer I, Touraine RL, Chouteau J, Wolf JP, Levy R (2008).
696:
691:
686:
681:
676:
660:
655:
650:
645:
640:
624:
619:
614:
609:
604:
1624:
1577:
1550:
1405:
1388:
1071:
591:
148:
1261:
1102:
1091:
406:
185:
172:
1188:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1170:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1527:
1352:
Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (2006).
489:
305:
202:
152:
1309:"Novel locus including FGF21 is associated with dietary macronutrient intake"
726:
549:
427:
372:
359:
271:
258:
160:
1535:
1502:
1457:
1414:
1379:
1344:
1253:
1201:
1483:
1044:
1039:
1370:
1353:
1326:
1028:
871:
852:
1245:
1079:
838:
793:
692:
fusion of sperm to egg plasma membrane involved in single fertilization
1439:
93:
89:
85:
81:
77:
73:
69:
1512:"Putative sperm fusion protein IZUMO and the role of N-glycosylation"
1012:
748:
1565:
1422:
Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P (2009).
1511:
1094:, is essential for sperm-egg plasma membrane binding and fusion.
711:
707:
1573:
1467:"Positive Selection and the Evolution of izumo Genes in Mammals"
1067:
140:
625:
protein binding involved in heterotypic cell-cell adhesion
396:
1585:
561:
1516:
973:
944:
918:
889:
1144:
1142:
1140:
1123:
1121:
1119:
343:
242:
1074:, IZUMO1 binds to its egg receptor counterpart,
16:Protein-coding gene in the species Homo sapiens
1149:GRCm38: Ensembl release 89: ENSMUSG00000064158
1090:The sperm-specific protein Izumo, named for a
1078:, to facilitate recognition and fusion of the
1605:
1471:International Journal of Evolutionary Biology
8:
1128:GRCh38: Ensembl release 89: ENSG00000182264
1612:
1598:
1547:United States National Library of Medicine
722:
587:
384:
283:
180:
58:
1492:
1482:
1447:
1404:
1369:
1334:
1545:This article incorporates text from the
1202:"Entrez Gene: Izumo sperm-egg fusion 1"
1115:
1428:Molecular Reproduction and Development
127:, IZUMO, OBF, izumo sperm-egg fusion 1
18:
1092:Japanese shrine dedicated to marriage
348:
309:
304:
247:
206:
201:
7:
1562:
1560:
1584:. You can help Knowledge (XXG) by
1510:Inoue N, Ikawa M, Okabe M (2008).
970:
941:
915:
886:
862:
843:
817:
798:
772:
753:
566:
484:
422:
401:
14:
610:protein homodimerization activity
1564:
1406:10.1016/j.fertnstert.2007.09.008
1057:Izumo sperm-egg fusion protein 1
332:
325:
319:
296:
231:
224:
218:
193:
1636:Human chromosome 19 gene stubs
1063:) is encoded in humans by the
697:heterotypic cell-cell adhesion
646:integral component of membrane
550:More reference expression data
458:right hemisphere of cerebellum
1:
1465:Grayson P, Civetta A (2012).
317:
216:
1631:Genes on human chromosome 19
1061:Sperm-specific protein izumo
1652:
1559:
1528:10.1016/j.bbrc.2008.10.073
605:signaling receptor binding
1184:"Mouse PubMed Reference:"
1166:"Human PubMed Reference:"
1043:
1038:
1034:
1027:
1011:
992:
977:
948:
937:
922:
893:
882:
869:
865:
850:
846:
837:
824:
820:
805:
801:
792:
779:
775:
760:
756:
747:
732:
725:
721:
705:
620:identical protein binding
590:
586:
574:
569:
560:
547:
496:
487:
434:
425:
395:
387:
383:
366:
353:
316:
295:
286:
282:
265:
252:
215:
192:
183:
179:
134:
131:
121:
114:
109:
66:
61:
44:
39:
34:
30:
26:
21:
1358:Human Molecular Genetics
1314:Human Molecular Genetics
998:Chr 19: 48.74 – 48.75 Mb
1393:Fertility and Sterility
1005:Chr 7: 45.62 – 45.63 Mb
454:upper lobe of left lung
682:sperm-egg recognition
209:Chromosome 19 (human)
687:single fertilization
466:right adrenal cortex
311:Chromosome 7 (mouse)
62:List of PDB id codes
35:Available structures
1484:10.1155/2012/958164
1246:10.1038/nature03362
1238:2005Natur.434..234I
1101:Through the use of
661:cytoplasmic vesicle
504:seminiferous tubule
1572:This article on a
1549:, which is in the
1371:10.1093/hmg/ddl417
1327:10.1093/hmg/ddt032
827:ENSMUSG00000064158
670:Biological process
656:acrosomal membrane
634:Cellular component
598:Molecular function
173:IZUMO1 - orthologs
1593:
1592:
1440:10.1002/mrd.21092
1054:
1053:
1050:
1049:
1023:
1022:
988:
987:
967:
966:
933:
932:
912:
911:
878:
877:
859:
858:
833:
832:
814:
813:
788:
787:
769:
768:
717:
716:
582:
581:
578:
577:
556:
555:
543:
542:
481:
480:
379:
378:
278:
277:
105:
104:
101:
100:
45:Ortholog search:
1643:
1614:
1607:
1600:
1568:
1561:
1539:
1506:
1496:
1486:
1461:
1451:
1418:
1408:
1383:
1373:
1348:
1338:
1293:
1290:
1284:
1281:
1275:
1272:
1266:
1265:
1221:
1215:
1212:
1206:
1205:
1198:
1192:
1191:
1180:
1174:
1173:
1162:
1156:
1146:
1135:
1125:
1036:
1035:
1007:
1000:
983:
971:
962:
942:
938:RefSeq (protein)
928:
916:
907:
887:
863:
844:
818:
799:
773:
754:
723:
588:
567:
552:
492:
490:Top expressed in
485:
450:body of pancreas
430:
428:Top expressed in
423:
402:
385:
375:
362:
351:
336:
329:
323:
312:
300:
284:
274:
261:
250:
235:
228:
222:
211:
197:
181:
175:
126:
119:
96:
59:
53:
32:
31:
19:
1651:
1650:
1646:
1645:
1644:
1642:
1641:
1640:
1621:
1620:
1619:
1618:
1557:
1542:
1509:
1464:
1434:(12): 1188–99.
1421:
1386:
1351:
1321:(9): 1895–902.
1306:
1302:
1300:Further reading
1297:
1296:
1291:
1287:
1282:
1278:
1273:
1269:
1232:(7030): 234–8.
1223:
1222:
1218:
1213:
1209:
1200:
1199:
1195:
1182:
1181:
1177:
1164:
1163:
1159:
1147:
1138:
1126:
1117:
1112:
1088:
1070:. In mammalian
1045:View/Edit Mouse
1040:View/Edit Human
1003:
996:
993:Location (UCSC)
979:
958:
954:
950:
924:
903:
899:
895:
808:ENSG00000182264
701:
665:
651:plasma membrane
629:
615:protein binding
548:
539:
534:
530:
526:
522:
518:
514:
510:
506:
502:
488:
477:
472:
468:
464:
462:body of stomach
460:
456:
452:
448:
444:
440:
426:
370:
357:
349:
339:
338:
337:
330:
310:
287:Gene location (
269:
256:
248:
238:
237:
236:
229:
207:
184:Gene location (
135:
122:
115:
68:
46:
17:
12:
11:
5:
1649:
1647:
1639:
1638:
1633:
1623:
1622:
1617:
1616:
1609:
1602:
1594:
1591:
1590:
1569:
1541:
1540:
1507:
1462:
1419:
1384:
1364:(23): 3411–9.
1349:
1303:
1301:
1298:
1295:
1294:
1285:
1276:
1267:
1216:
1207:
1193:
1175:
1157:
1136:
1114:
1113:
1111:
1108:
1087:
1084:
1052:
1051:
1048:
1047:
1042:
1032:
1031:
1025:
1024:
1021:
1020:
1018:
1016:
1009:
1008:
1001:
994:
990:
989:
986:
985:
975:
974:
968:
965:
964:
946:
945:
939:
935:
934:
931:
930:
920:
919:
913:
910:
909:
891:
890:
884:
880:
879:
876:
875:
867:
866:
860:
857:
856:
848:
847:
841:
835:
834:
831:
830:
822:
821:
815:
812:
811:
803:
802:
796:
790:
789:
786:
785:
777:
776:
770:
767:
766:
758:
757:
751:
745:
744:
739:
734:
730:
729:
719:
718:
715:
714:
703:
702:
700:
699:
694:
689:
684:
679:
673:
671:
667:
666:
664:
663:
658:
653:
648:
643:
637:
635:
631:
630:
628:
627:
622:
617:
612:
607:
601:
599:
595:
594:
584:
583:
580:
579:
576:
575:
572:
571:
564:
558:
557:
554:
553:
545:
544:
541:
540:
538:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
497:
494:
493:
482:
479:
478:
476:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
432:
431:
419:
418:
410:
399:
393:
392:
389:RNA expression
381:
380:
377:
376:
368:
364:
363:
355:
352:
347:
341:
340:
331:
324:
318:
314:
313:
308:
302:
301:
293:
292:
280:
279:
276:
275:
267:
263:
262:
254:
251:
246:
240:
239:
230:
223:
217:
213:
212:
205:
199:
198:
190:
189:
177:
176:
133:
129:
128:
120:
112:
111:
107:
106:
103:
102:
99:
98:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1648:
1637:
1634:
1632:
1629:
1628:
1626:
1615:
1610:
1608:
1603:
1601:
1596:
1595:
1589:
1587:
1583:
1579:
1578:chromosome 19
1575:
1570:
1567:
1563:
1558:
1555:
1554:
1552:
1551:public domain
1548:
1537:
1533:
1529:
1525:
1521:
1517:
1513:
1508:
1504:
1500:
1495:
1490:
1485:
1480:
1476:
1472:
1468:
1463:
1459:
1455:
1450:
1445:
1441:
1437:
1433:
1429:
1425:
1420:
1416:
1412:
1407:
1402:
1399:(4): 1246–8.
1398:
1394:
1390:
1385:
1381:
1377:
1372:
1367:
1363:
1359:
1355:
1350:
1346:
1342:
1337:
1332:
1328:
1324:
1320:
1316:
1315:
1310:
1305:
1304:
1299:
1289:
1286:
1280:
1277:
1271:
1268:
1263:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1231:
1227:
1220:
1217:
1211:
1208:
1203:
1197:
1194:
1189:
1185:
1179:
1176:
1171:
1167:
1161:
1158:
1154:
1150:
1145:
1143:
1141:
1137:
1133:
1129:
1124:
1122:
1120:
1116:
1109:
1107:
1104:
1099:
1095:
1093:
1085:
1083:
1081:
1077:
1073:
1072:fertilisation
1069:
1066:
1062:
1058:
1046:
1041:
1037:
1033:
1030:
1026:
1019:
1017:
1014:
1010:
1006:
1002:
999:
995:
991:
984:
982:
976:
972:
969:
963:
961:
957:
953:
947:
943:
940:
936:
929:
927:
921:
917:
914:
908:
906:
902:
898:
892:
888:
885:
883:RefSeq (mRNA)
881:
874:
873:
868:
864:
861:
855:
854:
849:
845:
842:
840:
836:
829:
828:
823:
819:
816:
810:
809:
804:
800:
797:
795:
791:
784:
783:
778:
774:
771:
765:
764:
759:
755:
752:
750:
746:
743:
740:
738:
735:
731:
728:
724:
720:
713:
709:
704:
698:
695:
693:
690:
688:
685:
683:
680:
678:
677:cell adhesion
675:
674:
672:
669:
668:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
638:
636:
633:
632:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
602:
600:
597:
596:
593:
592:Gene ontology
589:
585:
573:
568:
565:
563:
559:
551:
546:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
498:
495:
491:
486:
483:
474:apex of heart
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
436:
433:
429:
424:
421:
420:
417:
415:
411:
409:
408:
404:
403:
400:
398:
394:
390:
386:
382:
374:
369:
365:
361:
356:
346:
342:
335:
328:
322:
315:
307:
303:
299:
294:
290:
285:
281:
273:
268:
264:
260:
255:
245:
241:
234:
227:
221:
214:
210:
204:
200:
196:
191:
187:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
130:
125:
118:
113:
108:
97:
95:
91:
87:
83:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
1586:expanding it
1571:
1556:
1544:
1543:
1522:(3): 910–4.
1519:
1515:
1474:
1470:
1431:
1427:
1396:
1392:
1361:
1357:
1318:
1312:
1288:
1279:
1270:
1229:
1225:
1219:
1210:
1196:
1187:
1178:
1169:
1160:
1103:Western Blot
1100:
1096:
1089:
1064:
1060:
1056:
1055:
981:NP_001018013
978:
956:NP_001308794
952:NP_001308793
949:
926:NM_001018013
923:
905:NM_001321865
901:NM_001321864
894:
870:
851:
825:
806:
780:
761:
741:
736:
508:spermatocyte
438:right testis
412:
405:
132:External IDs
67:
442:left testis
371:45,628,823
358:45,621,811
350:7|7 B3
270:48,746,909
257:48,740,852
110:Identifiers
1625:Categories
1477:: 958164.
1155:, May 2017
1134:, May 2017
1110:References
516:blastocyst
470:right lung
416:(ortholog)
153:HomoloGene
1576:on human
960:NP_872381
897:NM_182575
727:Orthologs
536:esophagus
500:spermatid
161:GeneCards
1536:18952059
1503:22957301
1458:19658160
1415:18082733
1380:17047026
1345:23372041
1254:15759005
1151:–
1130:–
1086:Function
1029:Wikidata
706:Sources:
641:membrane
528:epiblast
524:yolk sac
249:19q13.33
1494:3432370
1449:3779078
1336:3612009
1262:4402928
1234:Bibcode
1153:Ensembl
1132:Ensembl
1080:gametes
839:UniProt
794:Ensembl
733:Species
712:QuickGO
391:pattern
149:1920706
117:Aliases
1534:
1501:
1491:
1456:
1446:
1413:
1378:
1343:
1333:
1260:
1252:
1226:Nature
1065:IZUMO1
1015:search
1013:PubMed
872:Q9D9J7
853:Q8IYV9
763:284359
749:Entrez
562:BioGPS
520:embryo
512:embryo
165:IZUMO1
141:609278
124:IZUMO1
22:IZUMO1
1580:is a
1258:S2CID
782:73456
742:Mouse
737:Human
708:Amigo
446:sperm
414:Mouse
407:Human
354:Start
289:Mouse
253:Start
186:Human
157:77701
1582:stub
1574:gene
1532:PMID
1499:PMID
1475:2012
1454:PMID
1411:PMID
1376:PMID
1341:PMID
1250:PMID
1076:Juno
1068:gene
397:Bgee
345:Band
306:Chr.
244:Band
203:Chr.
137:OMIM
94:5F4E
90:5F4V
86:5JKE
82:5JK9
78:5JKC
74:5F4T
70:5JKD
51:RCSB
48:PDBe
1524:doi
1520:377
1489:PMC
1479:doi
1444:PMC
1436:doi
1401:doi
1366:doi
1331:PMC
1323:doi
1242:doi
1230:434
1082:.
570:n/a
532:lip
367:End
266:End
169:OMA
145:MGI
41:PDB
1627::
1530:.
1518:.
1514:.
1497:.
1487:.
1473:.
1469:.
1452:.
1442:.
1432:76
1430:.
1426:.
1409:.
1397:90
1395:.
1391:.
1374:.
1362:15
1360:.
1356:.
1339:.
1329:.
1319:22
1317:.
1311:.
1256:.
1248:.
1240:.
1228:.
1186:.
1168:.
1139:^
1118:^
710:/
373:bp
360:bp
272:bp
259:bp
167:;
163::
159:;
155::
151:;
147::
143:;
139::
92:,
88:,
84:,
80:,
76:,
72:,
1613:e
1606:t
1599:v
1588:.
1553:.
1538:.
1526::
1505:.
1481::
1460:.
1438::
1417:.
1403::
1382:.
1368::
1347:.
1325::
1264:.
1244::
1236::
1204:.
1190:.
1172:.
1059:(
291:)
188:)
171::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
