375:
to scan the genomes of healthy people age 30 and older who contribute their DNA to the effort with an initial focus on 127 diseases. Scientists anticipated that finding protective mechanisms for
Mendelian diseases would be more straightforward than finding ones for complex or multifactorial diseases. Based on an analysis of publicly available data from 600,000 human genomes, scientists involved in the Resilience Project estimated that one person in 15,000 has a mechanism protecting against disease-causing genetic variants.
167:, biologists developing and testing new drugs and drug platforms, and data scientists working to identify causative agents of disease that can be targeted for therapy by building predictive models that better characterize disease. These models are constructed with multiple layers of biological data, including gene expression, metabolite, DNA, and protein information, and are combined with phenotypic and clinical data, predictive modeling, and probabilistic analysis to try to elucidate the complex mechanisms of disease.
138:. Its aim is to establish a new generation of medicines that can better treat diseases afflicting the world, including cancer, heart disease and infectious pathogens. To do this, the institute’s doctors and scientists are developing and employing new types of treatments that utilize DNA and RNA based therapies, such as
596:
Komiyama, Noboru H.; Collins, Mark O.; Fernández, Esperanza; Genovese, Giulio; Stahl, Eli; Duncan, Laramie; Kähler, Anna; Bergen, Sarah E.; Chambert, Kimberly; O’Dushlaine, Colm; Roussos, Panos; Solovieff, Nadia; Ruderfer, Douglas; Fromer, Menachem; Moran, Jennifer L.; Purcell, Shaun M. (1 February 2014).
374:
In 2014 the institute, in collaboration with Sage
Bionetworks, announced a new project aiming to genotype up to 1 million people with the goal of identifying the rare biological mechanisms that keep people healthy when they have genetic variants that should cause disease. The Resilience Project aimed
325:
Also in 2022, Brian Brown's research published results of a study targeting solid tumors with chimeric antigen receptor (CAR)-T cell therapy, which had previously only been successful in blood cancers. The researchers engineered CAR T cells to target and destroy macrophages, an immune cell supporting
228:
in 2012 demonstrating the ability to derive enough information from non-DNA sources to identify individuals whose supposedly anonymized biological data is stored in large research databases. The authors reported that measuring RNA levels in tissue allowed them to infer a genetic barcode that could be
989:
Mouhieddine, Tarek H.; Van
Oekelen, Oliver; Melnekoff, David T.; Li, Jeanne; Ghodke-Puranik, Yogita; Lancman, Guido; Thibaud, Santiago; Pan, Darren; Rajeeve, Sridevi; Agte, Sarita; Aleman, Adolfo; Sanchez, Larysa; Richard, Shambavi; Rossi, Adriana; Richter, Joshua; Cho, Hearn Jay; Rodriguez, Cesar;
595:
Sklar, Pamela; McCarroll, Steven A.; Sullivan, Patrick F.; Hultman, Christina M.; Lander, Eric S.; Scolnick, Edward M.; Gabriel, Stacey; Haggarty, Stephen J.; Grant, Seth G. N.; DePristo, Mark; Fennell, Tim; Garimella, Kiran; Shakir, Khalid; Banks, Eric; Magnusson, Patrik K. E.; Jyoti S. Choudhary;
537:
O’Donovan, Michael C.; Purcell, Shaun M.; Owen, Michael J.; Sklar, Pamela; Holmans, Peter; McCarroll, Steven A.; Palotie, Aarno; Kirov, George; Moran, Jennifer L.; Scolnick, Edward M.; Mahajan, Milind; Chambert, Kimberly; Rose, Samuel A.; Hannon, Eilis; Grant, Seth G.; Vihra
Milanova; Banks, Eric;
262:
that explored the genetic complexity of schizophrenia. The exome sequencing studies of populations in
Bulgaria and Sweden revealed that the disorder is likely caused by a lot of rare genetic mutations rather than a few common mutations. The projects also established the world’s largest database on
939:
Dhainaut, Maxime; Rose, Samuel; Akturk, Guray; Wroblewska, Aleksandra; Nielsen, Sebastian; Park, Eun; Buckup, Mark; Roudko, Vladimir; Pia, Luisanna; Sweeney, Robert; Le
Berichel, Jessica; Wilk, C. Matthias; Bektesevic, Anela; Lee, Brian; Bhardwaj, Nina; Rahman, Adeeb; Baccarini, Alessia; Gnjatic,
853:
Dhainaut, Maxime; Rose, Samuel A.; Akturk, Guray; Wroblewska, Aleksandra; Nielsen, Sebastian R.; Park, Eun Sook; Buckup, Mark; Roudko, Vladimir; Pia, Luisanna; Sweeney, Robert; Le
Berichel, Jessica; Wilk, C. Matthias; Bektesevic, Anela; Lee, Brian H.; Bhardwaj, Nina; Rahman, Adeeb H.; Baccarini,
1116:
Campisi, Laura; Chizari, Shahab; Ho, Jessica S. Y.; Gromova, Anastasia; Arnold, Frederick J.; Mosca, Lorena; Mei, Xueyan; Fstkchyan, Yesai; Torre, Denis; Beharry, Cindy; Garcia-Forn, Marta; Jiménez-Alcázar, Miguel; Korobeynikov, Vladislav A.; Prazich, Jack; Fayad, Zahi A.; Seldin, Marcus M.; De
238:
paper, institute founding director Eric Schadt led a research team that utilized six different types of data (metabolite concentration, gene expression, DNA variation, DNA-protein binding, protein-metabolite interaction, and protein–protein interaction) to reconstruct networks involved in cell
538:
Barker, Douglas D.; Roussos, Panos; Johnson, Jessica S.; Humphreys, Isla; Carrera, Noa; Ruderfer, Douglas M.; Palta, Priit; Rees, Elliott; Georgieva, Lyudmila; Gormley, Padhraig; Dwyer, Sarah; Williams, Hywel J.; Kavanagh, David H.; Pocklington, Andrew J.; Fromer, Menachem (1 February 2014).
162:
The institute’s primary goal is to improve patient care through the use of gene, cell and nucleotide therapies. To achieve this goal, the
Institute is formed of a cross-disciplinary mix of clinicians and scientists that include physicians treating patients with novel gene therapies in the
229:
used to match other materials to that same individual. This was noteworthy as validation of existing concerns among genomics scientists that it may not be possible to prevent the identification of an individual from genetic data even when that data is meant to be anonymous.
337:(ALS). The study found immune system dysfunction in patients and mice with ALS, and showed a high concentration of CD8 T cells in spinal cord and blood. The study was among the first publications to describe the immune system's involvement in neurodegeneration.
248:
reporting findings from a network-based study of late-onset
Alzheimer's disease. The researchers constructed gene regulatory networks and discovered a neural structure involved in a pathway associated with onset of the disease.
370:
Former institute member Joel Dudley was named one of the 100 most creative people in business in a 2014 list compiled by Fast
Company. The magazine said it chose Dudley "for splicing information with quality medical care."
154:, and searching for novel drug targets through the use of functional genomics and data science. The institute is led by Brian Brown, a leading expert in gene therapy, genetic engineering, and molecular immunology.
1049:
685:
Makiko Yasuda; Lin Gan; Brenden Chen; Senkottuvelan Kadirvel; Chunli Yu; John D Phillips; Maria I New; Abigail Liebow; Kevin Fitzgerald; William Querbes; Robert J Desnick (May 12, 2014).
367:, Michael Linderman, George Diaz, Ali Bashir, and Randi Zinberg taught the first class in which Mount Sinai medical students were able to fully sequence and analyze their own genomes.
1076:
1117:
Rubeis, Silvia; Bennett, Craig L.; Ostrow, Lyle W.; Lunetta, Christian; Squatrito, Massimo; Byun, Minji; Shneider, Neil A.; Jiang, Ning; La Spada, Albert R.; Marazzi, Ivan (2022).
1102:
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as the first therapy for acute hepatic porphyria, approved by the FDA in 2019. Institute researchers and clinicians also led the Phase 3 clinical trials for givosiran.
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Zhu, Jun; Sova, Pavel; Xu, Qiuwei; Dombek, Kenneth M.; Xu, Ethan Y.; Vu, Heather; Tu, Zhidong; Brem, Rachel B.; Bumgarner, Roger E.; Schadt, Eric E. (2012).
345:
The institute was formed in 2011 as the Institute for Genomics and Multiscale Biology, as part of Mount Sinai's Department of Genetics and Genomic Sciences.
911:
1505:
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357:
349:
was named as founding director. The institute was renamed in 2012 when philanthropist Carl Icahn pledged $ 200 million to its parent organization, the
1271:
1456:
1077:
https://aacrjournals.org/cancerimmunolres/article-abstract/10/11/1354/709883/Targeting-Macrophages-with-CAR-T-Cells-Delays?redirectedFrom=fulltext
382:. The center's goals included identification of biomarkers and drug targets for cancer and development of computational tools for drug discovery.
350:
131:
94:
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744:
1396:
1303:
https://www.clinicalresearchnewsonline.com/news/2014/05/23/for-students-at-the-icahn-school-of-medicine-genomics-is-growing-more-personal
687:"RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice"
1510:
839:
463:"Stitching together Multiple Data Dimensions Reveals Interacting Metabolomic and Transcriptomic Networks That Modulate Cell Regulation"
1515:
1205:
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imaging technology called Perturb-map capable of identifying regulators in tumor microenvironments. The findings were published in
418:
Schadt, Eric E.; Woo, Sangsoon; Hao, Ke (2012). "Bayesian method to predict individual SNP genotypes from gene expression data".
297:
receptor, TGFbR, as regulators of two pathways significantly affecting tumor growth, architecture, and immune cell recruitment.
925:
811:
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tumor growth, in ovarian, lung, and pancreatic tumors in mice models, which successfully shrunk tumors and prolonged survival.
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98:
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334:
1471:"Mount Sinai Designated as National Cancer Institute Proteogenomics Data Analysis Center | Mount Sinai - New York"
992:"Sequencing T-cell redirection therapies leads to deep and durable responses in relapsed/Refractory myeloma patients"
378:
In 2022, institute faculty Pei Wang and Avi Ma'ayan established a Proteogenomic Data Analysis Center funded by the
379:
315:
164:
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653:
513:"Cell - Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer's Disease"
1314:
1371:
266:
In May 2014, institute faculty published proof-of-concept findings to support the clinical development of
36:
912:"Novel CRISPR Imaging Technology Reveals Genes Controlling Tumor Immunity | Mount Sinai - New York"
319:
1457:"CPTAC Announces New PCC, PGDAC, and PTRC Teams | Office of Cancer Clinical Proteomics Research"
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1103:"New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models"
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893:
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443:
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1050:"Therapies That Engage T Cells Most Effective Against Relapsed or Refractory Multiple Myeloma"
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Lagana, Alessandro; Moshier, Erin L.; Chari, Ajai; Jagannath, Sundar; Parekh, Samir (2022).
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In January 2014, scientists from the institute’s Division of Psychiatric Genomics including
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826:"Cell Papers on Viruses in Chinese Game Animals, Perturb-map, Tumor-Associated Macrophages"
1272:"Q&A: Mount Sinai's Milind Mahajan on Running a CLIA-Certified Genomics Core Facility"
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322:(BiAbs) as a second-line treatment after a first-line immunotherapy treatment had failed.
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in 2022. Perturb-map was used in this study to identify the cytokine interferon gamma,
243:
1286:"Mount Sinai School of Medicine Offers First-Ever Course with Whole Genome Sequencing"
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patients. The study reported over an 80% response rate in patients treated with
204:
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871:
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Institute faculty member Samir Parekh published results of a clinical trial in
764:"Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria"
89:
942:"Spatial CRISPR genomics identifies regulators of the tumor microenvironment"
856:"Spatial CRISPR genomics identifies regulators of the tumor microenvironment"
854:
Alessia; Gnjatic, Sacha; Pe'Er, Dana; Merad, Miriam; Brown, Brian D. (2022).
1349:
1119:"Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4"
711:
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56:
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Manisha Balwani; Eliane Sardh; ENVISION Investigators (June 11, 2020).
1248:
1231:
1089:"Targeting of immune cells slows cancer growth in pre-clinical study"
311:
282:
195:
189:
1417:"How Healthy People Who Should be Sick Could Revolutionize Medicine"
1064:"Myeloma Patients Who Relapse After CAR T-Cell Therapy Have Options"
431:
940:
Sacha; Pe’er, Dana; Merad, Miriam; Brown, Brian (March 31, 2022).
672:"Schizophrenia could be caused by a wide variety of DNA mutations"
598:"A polygenic burden of rare disruptive mutations in schizophrenia"
329:
Institute faculty member Ivan Marazzi's research team published a
143:
1328:
Friend, S. H.; Schadt, E. E. (2014). "Clues from the resilient".
540:"De novo mutations in schizophrenia implicate synaptic networks"
290:
1397:""Genetic Heroes" May be Key to Treating Debilitating Diseases"
1375:
242:
In 2013, institute scientists published a paper in the journal
356:
In 2012, the institute received certification for the first
360:-approved next-generation sequencing lab in New York City.
130:
is a biomedical and genomics research institute within the
405:"Icahn Genomics Institute | Icahn School of Medicine"
16:
Biomedical and genomics research institute in New York, US
745:"FDA approves first treatment for inherited rare disease"
1206:"Carl Icahn to Give $ 200 Million to Mount Sinai School"
333:
paper in 2022 identifying the immune system's role in
306:(2022) focused on second-line treatments for relapsed
926:"Spatial CRISPR Genomics of Tumor Microenvironments"
840:"CRISPR Imaging Reveals Genes Behind Tumor Immunity"
812:"Spatial CRISPR Genomics of Tumor Microenvironments"
222:Scientists from the institute published a paper in
104:
88:
80:
72:
62:
42:
32:
24:
1181:"Partnering on Multiscale Biology - Bio-IT World"
281:Institute director, Brian Brown, developed a new
175:Research at the institute falls into six areas:
691:Proceedings of the National Academy of Sciences
8:
76:1425 Madison Avenue, New York, NY 10029-6501
19:
1437:"The Search for Genes That Prevent Disease"
1491:Genetics or genomics research institutions
18:
1247:
1142:
1017:
1007:
965:
879:
779:
720:
710:
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1501:Icahn School of Medicine at Mount Sinai
1372:"Welcome | the Resilience Project"
391:
351:Icahn School of Medicine at Mount Sinai
132:Icahn School of Medicine at Mount Sinai
95:Icahn School of Medicine at Mount Sinai
7:
399:
397:
395:
256:published two papers in the journal
768:The New England Journal of Medicine
14:
1506:Organizations established in 2011
1496:Laboratories in the United States
1009:10.1182/bloodadvances.2022007923
274:which led to the development of
1167:"New ALS Research Breakthrough"
749:US Food and Drug Administration
99:Mount Sinai Hospital, New York
1:
335:amyotrophic lateral sclerosis
218:Notable academic publications
480:10.1371/journal.pbio.1001301
213:Therapeutic Target Discovery
210:Cancer Gene and Cell Therapy
1532:
1511:Systems science institutes
1135:10.1038/s41586-022-04844-5
958:10.1016/j.cell.2022.02.015
872:10.1016/j.cell.2022.02.015
207:and Microbial Therapeutics
1516:American medical research
380:National Cancer Institute
316:chimeric antigen receptor
314:redirection therapy with
165:Mount Sinai Health System
295:tumor growth factor beta
128:Icahn Genomics Institute
20:Icahn Genomics Institute
1350:10.1126/science.1255648
712:10.1073/pnas.1406228111
192:, and Cell Engineering
44:Field of research
37:Translational research
781:10.1056/NEJMoa1913147
320:bispecific antibodies
1292:on December 9, 2022.
1236:Nature Biotechnology
952:(7): 1223–1239.e20.
866:(7): 1223–1239.e20.
751:. November 20, 2019.
1402:Scientific American
1342:2014Sci...344..970F
1230:Schadt, E. (2012).
703:2014PNAS..111.7777Y
658:www.bio-itworld.com
622:10.1038/nature12975
614:2014Natur.506..185P
564:10.1038/nature12929
556:2014Natur.506..179F
118:/genomics-institute
21:
1105:. 25 October 2022.
1066:. 4 November 2022.
1052:. 9 November 2022.
363:Institute faculty
318:(CAR)-T cells and
270:therapy for acute
33:Research type
1336:(6187): 970–972.
1274:. 8 January 2013.
1129:(7916): 945–952.
774:(24): 2289–2301.
697:(21): 7777–7782.
608:(7487): 185–190.
550:(7487): 179–184.
272:hepatic porphyria
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1422:Business Insider
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1374:. Archived from
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1288:. Archived from
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1249:10.1038/nbt.2331
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1183:. Archived from
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1002:(6): 1056–1064.
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928:. 16 March 2022.
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828:. 30 March 2022.
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515:. Archived from
509:
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365:Andrew Kasarskis
308:multiple myeloma
268:RNA interference
180:RNA Therapeutics
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22:
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473:(4): e1001301.
460:
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432:10.1038/ng.2248
420:Nature Genetics
417:
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263:schizophrenia.
225:Nature Genetics
220:
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45:
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11:
5:
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1242:(8): 769–770.
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996:Blood Advances
981:
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817:
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754:
736:
677:
663:
654:"Bio-IT World"
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587:
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504:
453:
426:(5): 603–608.
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303:Blood Advances
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15:
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1445:. 2014-05-29.
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1378:on 2014-08-03
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1343:
1339:
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1317:. 2014-05-12.
1316:
1315:"Joel Dudley"
1310:
1307:
1304:
1299:
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1278:
1273:
1267:
1264:
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1241:
1237:
1233:
1232:"Eric Schadt"
1226:
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1211:
1210:Bloomberg.com
1207:
1201:
1198:
1187:on 2012-01-11
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