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Influenza A virus subtype H1N1

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937:, and a further 250 were infected. As of early January 2014, Texas health officials have confirmed at least thirty-three H1N1 deaths and widespread outbreak during the 2013/2014 flu season, while twenty-one more deaths have been reported across the US. Nine people have been reported dead from an outbreak in several Canadian cities, and Mexico reports outbreaks resulting in at least one death. Spanish health authorities have confirmed 35 H1N1 cases in the Aragon region, 18 of whom are in intensive care. On 17 March 2014, three cases were confirmed with a possible fourth awaiting results occurring at the 675: 55: 921:
by World Health Organization (WHO) more than 214 countries and overseas territories or communities have reported laboratory confirmed cases of pandemic influenza H1N1 2009, including over 18,138 deaths. The research team of Andrew Miller showed pregnant patients are at increased risk. It has been suggested that pregnant women and certain populations such as native North Americans have a greater likelihood of developing a
798: 42: 848:(M) genes resembled versions present in European swine flu isolates. The six genes from American swine flu are themselves mixtures of swine flu, bird flu, and human flu viruses. While viruses with this genetic makeup had not previously been found to be circulating in humans or pigs, there is no formal national surveillance system to determine what viruses are circulating in pigs in the U.S. 215: 4895: 751:, New Jersey. The virus was detected only from 19 January to 9 February and did not spread beyond Fort Dix. Retrospective serologic testing subsequently demonstrated that up to 230 soldiers had been infected with the novel virus, which was an H1N1 strain. The cause of the outbreak is still unknown and no exposure to pigs was identified. 1125:(ECDC) and the US CDC stated that, like all flu viruses with pandemic potential, the variant is a concern that will be monitored. The ECDC stated that "the most important intervention in preparing for the pandemic potential of influenza viruses is the development and use of human vaccines ...". Health officials (including 773:. It infected mostly children and young adults under 23; because a similar strain was prevalent in 1947–57, most adults had substantial immunity. Later analysis found that the re-emergent strain had been circulating for approximately one year before it was detected in China and Russia. The virus was included in the 1978–79 2447: 904:, surmised as a leading cause of death in this pandemic. The study authors suggest physician evaluation via contrast enhanced CT scans for the presence of pulmonary emboli when caring for patients diagnosed with respiratory complications from a "severe" case of the H1N1 flu. H1N1 may induce other embolic events, such as 3461: 932:
On 26 April 2011, an H1N1 pandemic preparedness alert was issued by the World Health Organization for the Americas. In August 2011, according to the U.S. Geological Survey and the CDC, northern sea otters off the coast of Washington state were infected with the same version of the H1N1 flu virus that
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The 21 March 2010 worldwide update, by the U.N.'s World Health Organization (WHO), states that "213 countries and overseas territories/communities have reported laboratory confirmed cases of pandemic influenza H1N1 2009, including at least 16,931 deaths." As of 30 May 2010, worldwide update
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between 2011 and 2018. While other variants of the virus have appeared and diminished, the study claimed the G4 variant had sharply increased since 2016 to become the predominant strain. The Chinese Ministry of Agriculture and Rural Affairs rebutted the study, saying that the number of pigs sampled
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Since 1 October 2008, the CDC has tested 1,146 seasonal influenza A (H1N1) viruses for resistance against oseltamivir and zanamivir. It was found that 99.6% of the samples were resistant to oseltamivir while none were resistant to zanamivir. After 2009 Influenza A (H1N1) virus samples were tested,
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States and Mexico". The disease then spread very rapidly, with the number of confirmed cases rising to 2,099 by 7 May, despite aggressive measures taken by the Mexican government to curb the spread of the disease. The outbreak had been predicted a year earlier by noticing the increasing number of
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database. With similar timely sharing of data for Mexican isolates, by 24 April it became clear that the outbreak of ILI in Mexico and the confirmed cases of novel influenza A in the southwest US were related and WHO issued a health advisory on the outbreak of "influenza-like illness in the United
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migration towards the lungs, resulting in the destruction of lung cells and secretion of blood and mucus into the alveoli and airways. This makes it difficult for the patient to breathe and can result in suffocation. In contrast to other pandemics, which mostly kill the old and the very young, the
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Swine influenza virus is common throughout pig populations worldwide. Transmission of the virus from pigs to humans is not common and does not always lead to human influenza, often resulting only in the production of antibodies in the blood. If transmission does cause human influenza, it is called
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recommends that those who are pregnant be vaccinated to prevent the influenza virus. The vaccination should not be taken by people who have had a severe allergic reaction to the influenza vaccination. Those who are moderately to severely ill, with or without a fever should wait until they recover
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H1N1 Flu, 2009: Hearings before the Committee on Homeland Security and Governmental Affairs, United States Senate, of the One Hundred Eleventh Congress, First Session: 29 April 2009, Coordinating the Federal Response; 21 September 2009, Protecting Our Community: Field Hearing in Hartford, CT; 21
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Swine influenza (also known as swine flu or pig flu) is a respiratory disease that occurs in pigs that is caused by the Influenza A virus. Influenza viruses that are normally found in swine are known as swine influenza viruses (SIVs). The three main subtypes of SIV that circulate globally are
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was too small to demonstrate G4 had become the dominant strain and that the media had interpreted the study "in an exaggerated and nonfactual way". They also said the infected workers "did not show flu symptoms and the test sample is not representative of the pig population in China".
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isolated from patients in the United States was found to be made up of genetic elements from four different flu viruses – North American swine influenza, North American avian influenza, human influenza, and swine influenza virus typically found in Asia and Europe – "an unusually
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only 4% (of 853 samples) showed resistance to oseltamivir (again, no samples showed resistance to zanamivir). A study conducted in Japan during the 2009 H1N1 pandemic concluded that infants exposed to either oseltamivir or zanamivir had no short term adverse effects. Both
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since 2011. The Chinese CDC said it had implemented an influenza surveillance program in 2010, analyzing more than 400,000 tests annually, to facilitate early identification of influenza. Of those, 13 A(H1N1) cases were detected, of which three were of the G4 variant.
1090:) stated that "G4 EA H1N1 viruses possess all the essential hallmarks of being highly adapted to infect humans ... Controlling the prevailing G4 EA H1N1 viruses in pigs and close monitoring of swine working populations should be promptly implemented." 1129:) have said that the virus should be monitored, particularly among those in close contact with pigs, but it is not an immediate threat. While there have been no reported cases or evidence of the virus outside China as of July 2020, 1147:
Pregnant women who contract the H1N1 infection are at greater risk of developing complications because of hormonal changes, physical changes and changes to their immune system to accommodate the growing fetus. For this reason the
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of infrarenal aorta, thrombosis of right external iliac vein and common femoral vein or cerebral gas embolism. The type of embolic events caused by H1N1 infection are summarized in a 2010 review by Dimitroulis Ioannis et al.
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from a different strain and thus evolve to acquire new characteristics, enabling it to evade host immunity and occasionally to jump from one species of host to another. Major outbreaks of H1N1 strains in humans include the
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Maldives reported swine flu in early 2017; 501 people were tested for the disease and 185 (37%) of those tested were positive for the disease. Four of those who tested positive from these 185 died due to this disease.
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Cheung CY, Poon LL, Lau AS, et al. (December 2002). "Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?".
891:. The President's declaration caused many U.S. employers to take actions to help stem the spread of the swine flu and to accommodate employees and / or workflow which may have been impacted by an outbreak. 1040:
An outbreak of swine flu in the European Union member state was reported in mid-January 2019, with the island's main state hospital overcrowded within a week, with more than 30 cases being treated.
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has included one strain of A/H1N1 as well as two other influenza strains - together representing strains thought most likely to cause significant human suffering in the coming season.
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or a variant virus. People with regular exposure to pigs are at increased risk of swine flu infection. Properly cooking the meat of an infected animal removes the risk of infection.
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Schools were closed for a week due to the disease, but were ordered by the Ministry of Education to open after the holidays even though the disease was not fully under control.
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Saito, S; Minakami, H; Nakai, A; Unno, N; Kubo, T; Yoshimura, Y (August 2013). "Outcomes of infants exposed to oseltamivir or zanamivir in utero during pandemic (H1N1) 2009".
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Nakajima, Katsuhisa; Desselberger, Ulrich; Palese, Peter (July 1978). "Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950".
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1918 pandemic killed unusual numbers of young adults, which may have been due to their healthy immune systems mounting a too-strong and damaging response to the infection.
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Pregnant women who become infected with the influenza are advised to contact their doctor immediately. Influenza can be treated with prescription antiviral medications.
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With more than 300 infections and over 20 deaths, India's health ministry declared an outbreak "well under control" with "no reason to panic" in April 2012.
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caused the 2009 pandemic and "may be a newly identified animal host of influenza viruses". In May 2013, seventeen people died during an H1N1 outbreak in
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A(H1N1), A(H1N2), and A(H3N2). These subtypes are well adapted to pigs and are different from human influenza viruses of the same subtype.
3624:"The swine flu virus is not a new virus and does not very spread and is pathogenic to humans and animals [translated from Chinese]" 3417: 2516:
One company, Replikins, actually predicted over a year ago that significant outbreaks of the H1N1 flu virus would occur within 6–12 months.
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to provide help to control the virus; and also mentioned that the government would be seeking international assistance, including from the
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A study conducted in coordination with the University of Michigan Health Service – scheduled for publication in the December 2009
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4 (G4) Eurasian avian-like (EA) H1N1 virus that mainly affects pigs, but there is some evidence of it infecting people. A 2020
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showed clinical signs of flu within four days, and the virus spread to other uninfected pigs housed with the infected ones.
1260: 3884: 4885: 2546: 3772: 3027: 4500: 4418: 1121:(CDC) said the study suggested that human infection by the G4 virus is more common than it was thought to be. Both the 447: 4403: 3527:"Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection" 596:
Each year, three influenza strains are chosen for inclusion in the forthcoming year's seasonal flu vaccination by the
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October 2009, Monitoring the Nation's Response; 17 November 2009, Getting the Vaccine to Where It is Most Needed.
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Cohen, Jon (29 June 2020). "Swine flu strain with human pandemic potential increasingly found in pigs in China".
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country where the press were printing reports of the outbreak, which had killed thousands in the armies fighting
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declared an H1N1 pandemic, moving the alert level to phase 6, marking the first global pandemic since the 1968
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In 1976, a novel swine influenza A (H1N1) caused severe respiratory illness in 13 soldiers, with one death at
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In November 2019 an outbreak of H1N1 was recorded in Iran, with 56 fatalities and 4,000 people hospitalized.
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reported H1N1 in late July 2017. As of 27 July, there were 30 confirmed cases and six people had died. The
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The total number of people who have died due to the disease is unknown. Patient Zero was never identified.
372: 4911: 4862: 4466: 4434: 4369: 3490: 1179:(antiviral medications) recommended. They are most effective when taken within two days of becoming sick. 852: 792: 538: 480: 470: 193: 20: 2885: 2163: 1024:, with deaths resulting from the epidemic reaching 42. There have also been confirmed cases in cities of 4444: 3357: 2583: 905: 2384: 971:, 31,974 cases of swine flu had been reported and 1,895 people had died from an outbreak by mid-March. 3944: 2757: 4454: 3623: 3538: 3427: 2923: 2109: 2054: 1735: 1678: 1582: 1139:, but because it "so far cannot jump from person to person", it should not be a cause for alarm yet. 1131: 748: 49: 1724:"Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus" 4514: 4398: 4115: 2578: 1162: 1110: 913: 310: 2828: 2185: 1283: 4646: 4588: 4471: 4335: 4105: 4068: 3687: 2499: 2078: 1854: 1805: 1704: 1552: 901: 888: 542: 475: 365: 322: 859:
reported seven cases of novel A/H1N1 influenza and promptly shared the genetic sequences on the
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Carnegie Library during the Spanish flu pandemic in 1918, all garbed in uniforms and face masks.
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genome. Under rare circumstances, one strain of the virus can acquire genetic material through
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In January 2019 an outbreak of H1N1 was recorded in Morocco, with nine confirmed fatalities.
4811: 4756: 4746: 4684: 4348: 4171: 4166: 4161: 4151: 3983: 3856: 3848: 3679: 3564: 3546: 3138: 3128: 2800: 2792: 2630: 2622: 2421: 2310:"Swine influenza A (H1N1) infection in two children – Southern California, March–April 2009" 2127: 2117: 2062: 1935: 1927: 1836: 1789: 1751: 1743: 1686: 1637: 1627: 1499: 1380: 1372: 1331: 1321: 1199:(malformations and toxic effects on the embryo) when given at high doses in animal studies. 1069: 840:(HA) gene was similar to that of swine flu viruses present in U.S. pigs since 1999, but the 818: 766: 760: 656: 586: 392: 248: 243: 139: 1068:, also known as the "G4 swine flu virus" (G4) and "G4 EA H1N1", is a swine influenza virus 214: 4784: 4768: 1526: 830: 826: 802: 694: 660: 550: 546: 253: 231: 127: 115: 103: 2309: 1101:, stated in July 2020 that this strain of influenza virus was not new and had been under 3542: 2113: 2058: 1739: 1682: 686:
The 1918 flu caused an abnormally high number of deaths, possibly due to it provoking a
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Pigs experimentally infected with the strain of swine flu that caused the
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For the H1N1/09 virus strain responsible for the 2009 flu pandemic, see
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Butler, Declan (27 April 2009). "Swine flu outbreak sweeps the globe".
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WHO report on global surveillance of epidemic-prone infectious diseases
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Jilani TN, Jamil RT, Siddiqui AH (30 November 2020). "H1N1 Influenza".
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The Great Influenza: The Epic Story of the Greatest Plague in History
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reported in July 2020 that scientists agree that the virus should be
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mix of genetic sequences." This new strain appears to be a result of
726: 4905: 4054: 3806:"New Swine flu strain with pandemic potential isn't cause for alarm" 3742:. European Centre for Disease Prevention and Control. 13 July 2020. 3648:. European Centre for Disease Prevention and Control. 13 July 2020. 3626:. Ministry of Agriculture of the People's Republic of China. 2020. 1841: 1824: 925:
type 2 response to H1N1 influenza which may be responsible for the
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The study stated that almost 30,000 swine had been monitored via
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infected lung cells, it frequently led to overstimulation of the
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Database of influenza genomic sequences and related information.
710: 691: 4909: 4064: 3773:"4 reasons not to worry about that 'new' swine flu in the news" 3288:"Myanmar tracks spread of H1N1 as outbreak claims sixth victim" 2308:
Centers for Disease Control and Prevention (CDC) (April 2009).
4048: 3386:"Swine flu outbreak at Mater Dei hospital, St Vincent de Paul" 1310:"Evolution of Influenza A Virus by Mutation and Re-Assortment" 909: 876: 697:, also an Influenza A virus, has a similar effect.) After the 2609:
Mollura DJ, Asnis DS, Crupi RS, et al. (December 2009).
1583:"1918 Pandemic (H1N1 virus) | Pandemic Influenza (Flu) | CDC" 1410:"Genetics of the Influenza Virus | Learn Science at Scitable" 4060: 2349: 2347: 1553:"Humans May Give Swine Flu To Pigs In New Twist To Pandemic" 855:(ILI) occurred in Mexico and then in the United States; the 2862:. U.S. Department of the Interior, U.S. Geological Survey. 2660:"H1N1 infection and embolic events. A multifaceted disease" 1462:"Global Influenza Surveillance and Response System (GISRS)" 3945:"2008–2009 Influenza Season Week 32 ending 15 August 2009" 2361:. World Health Organization. 24 April 2009. Archived from 1722:
Kash JC, Tumpey TM, Proll SC, et al. (October 2006).
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Kobasa D, Jones SM, Shinya K, et al. (January 2007).
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Gaydos JC, Top FH, Hodder RA, Russell PK (January 2006).
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European Centre for Disease Prevention and Control (ECDC)
553:). Subtypes of IAV are defined by the combination of the 3167:"Makeshift flu clinics swamped as H1N1 cases rise to 82" 2998:"Aumentan a 35 los hospitalizados por gripe A en AragΓ³n" 2726:. World Health Organization. 4 June 2010. Archived from 2446:. Epidemiological Alerts Vol. 6, No. 15. 29 April 2009. 2355:"Influenza-like illness in the United States and Mexico" 1916:"Swine influenza a outbreak, Fort Dix, New Jersey, 1976" 1308:
Shao W, Li X, Goraya MU, Wang S, Chen JL (August 2017).
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viruses, in all four different strains of subtype H1N1.
709:(proteins that transmit signals between cells) into the 4042: 2476:. World Health Organization. 7 May 2009. Archived from 2256:"Deadly new flu virus in US and Mexico may go pandemic" 4883: 3737:"Eurasian avian-like A(H1N1) swine influenza viruses" 3643:"Eurasian avian-like A(H1N1) swine influenza viruses" 3117:"The 2015 influenza A (H1N1) pdm09 outbreak in India" 1487:
Anker M, Schaaf D, World Health Organization (2000).
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Caruana, Claire; Xuereb, Matthew (18 January 2019).
2440:"Influenza cases by a new sub-type: Regional Update" 1020:
reported H1N1 cases mostly arising from the city of
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Preliminary genetic characterization found that the
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For the 1918 influenza A (H1N1) pandemic, see 3531:Proceedings of the National Academy of Sciences 2547:"Obama declares swine flu a national emergency" 1083:Proceedings of the National Academy of Sciences 3841:Journal of Obstetrics and Gynaecology of India 2916:"North Texas confirmed 20 flu deaths – Xinhua" 2500:"Efforts To Quickly Develop Swine Flu Vaccine" 537:(IAV). Some human-adapted strains of H1N1 are 4076: 3976:American Journal of Obstetrics and Gynecology 3618: 3616: 3614: 507: 8: 2750:"H1N1 Pandemic Flu Hits Pregnant Women Hard" 2390:. World Health Organization. 15 April 2009. 1072:discovered in China. The virus is a variant 3321:"Myanmar Asks WHO to Help Fight H1N1 Virus" 2968:"Un muerto en Coahuila por influenza AH1N1" 2696:. World Health Organization. Archived from 2020:"New Strain May Edge Out Seasonal Flu Bugs" 1464:. World Health Organization. Archived from 1314:International Journal of Molecular Sciences 705:via release of immune response-stimulating 4906: 4736: 4642: 4519: 4490: 4388: 4331: 4083: 4069: 4061: 4049:Centers For Disease Control and Prevention 3949:Centers for Disease Control and Prevention 3919:Centers for Disease Control and Prevention 3889:Centers for Disease Control and Prevention 3520: 3518: 3516: 3495:Centers for Disease Control and Prevention 3485: 3483: 3481: 3479: 2694:"Situation updates – Pandemic (H1N1) 2009" 1440:Centers for Disease Control and Prevention 1288:Centers for Disease Control and Prevention 1224:Centers for Disease Control and Prevention 1150:Centers for Disease Control and Prevention 1119:Centers for Disease Control and Prevention 721:The term "Spanish" flu was coined because 514: 500: 202: 40: 31: 3860: 3766: 3764: 3568: 3550: 3454:"Ψ’Ω†ΩΩˆΩ„Ψ§Ω†Ψ²Ψ§ و Ψ±Ψ§Ω‡β€ŒΩ‡Ψ§ΫŒ Ψ―Ψ±Ω…Ψ§Ω† Ψ’Ω† Ψ±Ψ§ Ψ¨Ψ΄Ω†Ψ§Ψ³ΫŒΨ―" 3142: 3132: 2804: 2634: 2131: 2121: 1939: 1840: 1755: 1690: 1641: 1631: 1503: 1384: 1335: 1325: 3595:. Xinhuanet. 2 July 2020. Archived from 2938:"9 deaths caused by H1N1 flu in Alberta" 1994:"Origin of current influenza H1N1 virus" 1093:Michael Ryan, executive director of the 796: 673: 4890: 3731: 3729: 3727: 3418:"Swine flu outbreak kills 9 in Morocco" 3286:Lone, Wa; Lewis, Simon (27 July 2017). 2444:Pan American Health Organization (PAHO) 1208: 1001:of Myanmar sent an official request to 929:that causes pulmonary edema and death. 927:systemic inflammatory response syndrome 205: 3885:"Key Facts about Seasonal Flu Vaccine" 3028:"Three cases of H1N1 reported at CAMH" 2236:from the original on 27 September 2006 939:Centre for Addiction and Mental Health 4873:US influenza statistics by flu season 3300:from the original on 11 December 2018 3115:Murhekar M, Mehendale S (June 2016). 3084:"Swine flu toll inches towards 1,900" 2450:from the original on 1 September 2017 2230:State of Alaska Epidemiology Bulletin 1515:from the original on 31 October 2022. 883:. On 25 October 2009, U.S. President 7: 4014:Sarasota Memorial Health Care System 3925:from the original on 23 January 2014 3464:from the original on 3 December 2019 3365:from the original on 25 January 2018 3257:"Schools to open after flu outbreak" 3008:from the original on 12 January 2014 2590:from the original on 15 October 2011 2553:from the original on 29 October 2009 2026:from the original on 26 January 2012 2000:from the original on 12 January 2012 1974:from the original on 27 October 2011 1563:from the original on 26 January 2021 1214: 1212: 3434:from the original on 16 August 2019 3398:from the original on 16 August 2019 3333:from the original on 28 August 2019 2978:from the original on 7 January 2014 2858:Rogall, Gail Moede (8 April 2014). 2720:"Pandemic (H1N1) 2009 – update 103" 2332:from the original on 1 October 2009 655:was an unusually severe and deadly 4868:2017–2018 United States flu season 3267:from the original on 26 March 2017 3237:from the original on 26 March 2017 3207:from the original on 25 March 2017 3177:from the original on 24 March 2017 3038:from the original on 30 March 2019 2896:from the original on 30 March 2019 2866:from the original on 13 April 2014 2839:from the original on 29 April 2011 2397:from the original on 7 August 2017 2262:from the original on 29 April 2009 2184:. 20 February 1978. 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Archived from 2281:Susan Watts (25 April 2009). 1794:10.1016/S0140-6736(02)11772-7 1436:"Seasonal Flu Vaccines | CDC" 999:Ministry of Health and Sports 771:Influenza A/USSR/90/77 (H1N1) 2314:MMWR Morb. Mortal. Wkly. Rep 2123:10.1371/journal.pone.0011184 1365:Nature Reviews. Microbiology 1248:H1N1 Influenza in StatPearls 568:All subtypes of IAV share a 16:Subtype of Influenza A virus 4043:Influenza Research Database 3060:. BBC News. 12 April 2012. 2178:"Invasion from the Steppes" 2096:Wertheim, Joel. O. (2010). 887:officially declared H1N1 a 298:Seasonal flu vaccine brands 5003: 4440:Transmission and infection 3988:10.1016/j.ajog.2013.04.007 3804:Machemer T (6 July 2020). 2549:. The Daily Herald. 2009. 1823:Palese P (December 2004). 1508:. WHO/CDS/CSR/ISR/2000.1. 1416:. 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Reuters. 4 July 2020. 3261:Maldives Independent.com 3231:Maldives Independent.com 3171:Maldives Independent.com 3134:10.4103/0971-5916.192077 2586:, LLP. 2 November 2009. 1177:neuraminidase inhibitors 967:According to the Indian 557:H and N proteins in the 4549:Neuraminidase inhibitor 3684:10.1126/science.abd5761 3552:10.1073/pnas.1921186117 2158:1977: Russian flu scare 1282:CDC (1 February 2024). 787:2009 swine flu pandemic 743:1976 swine flu outbreak 737:1976 swine flu outbreak 591:2009 swine flu pandemic 448:2020–2022 H5N8 outbreak 4950:Influenza A virus H1N1 4863:Influenza-like illness 4532:Adamantane derivatives 3891:. 2013. Archived from 1932:10.3201/eid1201.050965 1408:Clancy, Susan (2008). 1191:have been found to be 1143:Infection in pregnancy 975:2017 Maldives outbreak 872:, found in the virus. 853:influenza-like illness 805: 793:Pandemic H1N1/09 virus 683: 641:1918–1920 flu pandemic 486:Vaccine reformulations 481:Influenza-like illness 428:2007 Australian equine 194:Pandemic H1N1/09 virus 21:Pandemic H1N1/09 virus 4713:1989–1990 UK outbreak 4675:Asian flu (1957-1958) 4051:H1N1 Flu (Swine Flu). 2797:10.1503/cmaj.109-2028 2724:Disease Outbreak News 2584:Davis Wright Tremaine 2474:Disease Outbreak News 2426:10.1038/news.2009.408 2359:Disease Outbreak News 2188:on 30 September 2007. 2162:. CNN. Archived from 1044:2019 Morocco outbreak 990:2017 Myanmar outbreak 906:myocardial infarction 875:On 11 June 2009, the 800: 791:Further information: 781:2009 A(H1N1) pandemic 769:was caused by strain 677: 373:1889-1890 Russian flu 4680:Hong Kong flu (1968) 4472:Pandemic preparation 3810:Smithsonian Magazine 2781:"H1N1-related SIRS?" 2232:(9). 21 April 1978. 1920:Emerging Infect. Dis 1835:(12 Suppl): S82–87. 1327:10.3390/ijms18081650 1153:before vaccination. 1132:Smithsonian Magazine 908:, bilateral massive 578:genetic reassortment 50:Virus classification 3982:(2): 130.e1–39.e1. 3543:2020PNAS..11717204S 3537:(29): 17204–17210. 3430:. 2 February 2019. 3361:. 24 January 2018. 3004:. 12 January 2014. 2926:on 12 January 2014. 2674:on 13 December 2019 2627:10.2214/AJR.09.3365 2615:AJR Am J Roentgenol 2579:National Law Review 2202:. Global Security. 2114:2010PLoSO...511184W 2059:1978Natur.274..334N 2022:. 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(The 684: 623:zoonotic swine flu 606:annual formulation 543:seasonal influenza 533:) is a subtype of 476:Influenza research 388:1968 Hong Kong flu 323:Baloxavir marboxil 4974: 4973: 4912:Taxon identifiers 4881: 4880: 4798: 4797: 4728: 4727: 4708:Fujian flu (H3N2) 4630: 4629: 4509: 4508: 4480: 4479: 4435:Genetic structure 4378: 4377: 4182:Influenza A virus 4121:Genome sequencing 3493:(Press release). 3263:. 23 March 2017. 3233:. 21 March 2017. 3203:. 25 March 2017. 3173:. 15 March 2017. 3034:. 21 March 2014. 2972:Vanguardia.com.mx 2835:. 26 April 2011. 2833:Recombinomics.com 2420:: news.2009.408. 2166:on 22 March 2007. 2053:(5669): 334–339. 1888:978-0-670-89473-4 1788:(9348): 1831–37. 1626:(12): 2561–2567. 1589:. 22 March 2020. 1468:on 3 October 2011 1137:closely monitored 914:arterial thrombus 810:2009 flu pandemic 775:influenza vaccine 535:influenza A virus 524: 523: 201: 200: 166:Influenza A virus 4994: 4967: 4966: 4954: 4953: 4952: 4939: 4938: 4937: 4907: 4898: 4897: 4889: 4812:Acute bronchitis 4737: 4690:Swine flu (2009) 4685:1977 Russian flu 4643: 4579: 4520: 4491: 4389: 4354:2009 (Swine flu) 4332: 4152:Orthomyxoviridae 4085: 4078: 4071: 4062: 4030: 4029: 4027: 4025: 4016:. Archived from 4010:"Pandemic OBGYN" 4006: 4000: 3999: 3971: 3965: 3964: 3962: 3960: 3941: 3935: 3934: 3932: 3930: 3911: 3905: 3904: 3902: 3900: 3881: 3875: 3874: 3864: 3832: 3826: 3825: 3823: 3821: 3801: 3795: 3794: 3792: 3790: 3768: 3759: 3758: 3756: 3754: 3748: 3741: 3733: 3722: 3721: 3719: 3717: 3702: 3696: 3695: 3671: 3665: 3664: 3662: 3660: 3654: 3647: 3640:Translation via 3639: 3637: 3635: 3620: 3609: 3608: 3606: 3604: 3589: 3583: 3582: 3572: 3554: 3522: 3511: 3510: 3508: 3506: 3487: 3474: 3473: 3471: 3469: 3450: 3444: 3443: 3441: 3439: 3414: 3408: 3407: 3405: 3403: 3381: 3375: 3374: 3372: 3370: 3349: 3343: 3342: 3340: 3338: 3316: 3310: 3309: 3307: 3305: 3283: 3277: 3276: 3274: 3272: 3253: 3247: 3246: 3244: 3242: 3223: 3217: 3216: 3214: 3212: 3193: 3187: 3186: 3184: 3182: 3163: 3157: 3156: 3146: 3136: 3112: 3106: 3105: 3103: 3101: 3096:on 20 March 2015 3080: 3074: 3073: 3071: 3069: 3054: 3048: 3047: 3045: 3043: 3024: 3018: 3017: 3015: 3013: 2994: 2988: 2987: 2985: 2983: 2964: 2958: 2957: 2955: 2953: 2934: 2928: 2927: 2922:. Archived from 2912: 2906: 2905: 2903: 2901: 2882: 2876: 2875: 2873: 2871: 2855: 2849: 2848: 2846: 2844: 2825: 2819: 2818: 2808: 2776: 2770: 2769: 2767: 2765: 2754:Businessweek.com 2746: 2740: 2739: 2737: 2735: 2716: 2710: 2709: 2707: 2705: 2690: 2684: 2683: 2681: 2679: 2655: 2649: 2648: 2638: 2606: 2600: 2599: 2597: 2595: 2569: 2563: 2562: 2560: 2558: 2543: 2537: 2536: 2535:on 15 June 2009. 2525: 2519: 2518: 2513: 2511: 2496: 2490: 2489: 2487: 2485: 2466: 2460: 2459: 2457: 2455: 2436: 2430: 2429: 2413: 2407: 2406: 2404: 2402: 2396: 2389: 2381: 2375: 2374: 2372: 2370: 2365:on 26 April 2009 2351: 2342: 2341: 2339: 2337: 2305: 2299: 2298: 2296: 2294: 2278: 2272: 2271: 2269: 2267: 2252: 2246: 2245: 2243: 2241: 2222: 2216: 2215: 2213: 2211: 2196: 2190: 2189: 2174: 2168: 2167: 2152: 2146: 2145: 2135: 2125: 2093: 2087: 2086: 2067:10.1038/274334a0 2042: 2036: 2035: 2033: 2031: 2016: 2010: 2009: 2007: 2005: 1990: 1984: 1983: 1981: 1979: 1960: 1954: 1953: 1943: 1911: 1905: 1904: 1902: 1900: 1869: 1863: 1862: 1844: 1820: 1814: 1813: 1776: 1770: 1769: 1759: 1734:(7111): 578–81. 1719: 1713: 1712: 1694: 1677:(7125): 319–23. 1662: 1656: 1655: 1645: 1635: 1609: 1603: 1602: 1600: 1598: 1579: 1573: 1572: 1570: 1568: 1559:. 10 July 2009. 1557:Sciencedaily.com 1549: 1543: 1542: 1540: 1538: 1523: 1517: 1516: 1514: 1507: 1493: 1484: 1478: 1477: 1475: 1473: 1458: 1452: 1451: 1449: 1447: 1432: 1426: 1425: 1423: 1421: 1405: 1399: 1398: 1388: 1356: 1350: 1349: 1339: 1329: 1305: 1299: 1298: 1296: 1294: 1279: 1273: 1272: 1270: 1268: 1242: 1236: 1235: 1233: 1231: 1216: 1080:paper from the 761:1977 Russian flu 755:1977 Russian flu 561:; for example, " 549:) and in birds ( 516: 509: 502: 438:2008 West Bengal 393:1977 Russian flu 378:1918 Spanish flu 217: 203: 141:Orthomyxoviridae 58: 57: 44: 32: 5002: 5001: 4997: 4996: 4995: 4993: 4992: 4991: 4977: 4976: 4975: 4970: 4962: 4957: 4948: 4947: 4942: 4933: 4932: 4927: 4914: 4904: 4892: 4884: 4882: 4877: 4851: 4794: 4773: 4724: 4694: 4639: 4637: 4626: 4593: 4577: 4524:Antiviral drugs 4505: 4476: 4462:Human mortality 4455:clinical trials 4423: 4374: 4358: 4321: 4185: 4183: 4176: 4140: 4094: 4089: 4039: 4034: 4033: 4023: 4021: 4008: 4007: 4003: 3973: 3972: 3968: 3958: 3956: 3943: 3942: 3938: 3928: 3926: 3913: 3912: 3908: 3898: 3896: 3895:on 30 June 2017 3883: 3882: 3878: 3834: 3833: 3829: 3819: 3817: 3803: 3802: 3798: 3788: 3786: 3770: 3769: 3762: 3752: 3750: 3746: 3739: 3735: 3734: 3725: 3715: 3713: 3704: 3703: 3699: 3673: 3672: 3668: 3658: 3656: 3652: 3645: 3641: 3633: 3631: 3622: 3621: 3612: 3602: 3600: 3591: 3590: 3586: 3524: 3523: 3514: 3504: 3502: 3497:. 2 July 2020. 3489: 3488: 3477: 3467: 3465: 3452: 3451: 3447: 3437: 3435: 3416: 3415: 3411: 3401: 3399: 3383: 3382: 3378: 3368: 3366: 3351: 3350: 3346: 3336: 3334: 3318: 3317: 3313: 3303: 3301: 3285: 3284: 3280: 3270: 3268: 3255: 3254: 3250: 3240: 3238: 3225: 3224: 3220: 3210: 3208: 3195: 3194: 3190: 3180: 3178: 3165: 3164: 3160: 3114: 3113: 3109: 3099: 3097: 3082: 3081: 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1977: 1975: 1962: 1961: 1957: 1913: 1912: 1908: 1898: 1896: 1889: 1871: 1870: 1866: 1822: 1821: 1817: 1778: 1777: 1773: 1721: 1720: 1716: 1664: 1663: 1659: 1611: 1610: 1606: 1596: 1594: 1581: 1580: 1576: 1566: 1564: 1551: 1550: 1546: 1536: 1534: 1533:. 14 March 2023 1525: 1524: 1520: 1512: 1491: 1486: 1485: 1481: 1471: 1469: 1460: 1459: 1455: 1445: 1443: 1442:. 12 March 2024 1434: 1433: 1429: 1419: 1417: 1407: 1406: 1402: 1358: 1357: 1353: 1307: 1306: 1302: 1292: 1290: 1281: 1280: 1276: 1266: 1264: 1244: 1243: 1239: 1229: 1227: 1218: 1217: 1210: 1205: 1165: 1159: 1145: 1062: 1054: 1046: 1038: 1015: 992: 977: 969:Health Ministry 965: 959: 951: 831:swine influenza 827:human influenza 803:antigenic shift 795: 789: 783: 763: 757: 745: 739: 661:avian influenza 649: 643: 638: 614: 612:Swine influenza 551:avian influenza 547:swine influenza 520: 491: 490: 461: 453: 452: 423:2006 H5N1 India 413: 403: 402: 368: 358: 357: 313: 303: 302: 293:Live attenuated 276: 266: 265: 227: 207:Influenza (flu) 181: 169: 129:Articulavirales 117:Insthoviricetes 105:Negarnaviricota 52: 28: 17: 12: 11: 5: 5000: 4998: 4990: 4989: 4979: 4978: 4972: 4971: 4969: 4968: 4955: 4940: 4924: 4922: 4916: 4915: 4910: 4903: 4902: 4879: 4878: 4876: 4875: 4870: 4865: 4859: 4857: 4856:Related topics 4853: 4852: 4850: 4849: 4844: 4839: 4834: 4829: 4824: 4819: 4814: 4808: 4806: 4800: 4799: 4796: 4795: 4793: 4792: 4787: 4781: 4779: 4775: 4774: 4772: 4771: 4766: 4765: 4764: 4754: 4749: 4743: 4741: 4734: 4730: 4729: 4726: 4725: 4723: 4722: 4717: 4716: 4715: 4704: 4702: 4696: 4695: 4693: 4692: 4687: 4682: 4677: 4672: 4667: 4662: 4657: 4651: 4649: 4640: 4635: 4632: 4631: 4628: 4627: 4625: 4624: 4619: 4614: 4609: 4603: 4601: 4595: 4594: 4592: 4591: 4586: 4581: 4578:(experimental) 4573: 4572: 4571: 4566: 4561: 4556: 4546: 4545: 4544: 4539: 4528: 4526: 4517: 4511: 4510: 4507: 4506: 4504: 4503: 4497: 4495: 4488: 4482: 4481: 4478: 4477: 4475: 4474: 4469: 4464: 4459: 4458: 4457: 4447: 4442: 4437: 4431: 4429: 4425: 4424: 4422: 4421: 4419:2020s outbreak 4416: 4411: 4406: 4401: 4399:Croatia (2005) 4395: 4393: 4386: 4380: 4379: 4376: 4375: 4373: 4372: 4366: 4364: 4360: 4359: 4357: 4356: 4351: 4346: 4340: 4338: 4329: 4323: 4322: 4320: 4319: 4314: 4309: 4304: 4299: 4294: 4289: 4284: 4279: 4274: 4269: 4264: 4259: 4254: 4249: 4244: 4239: 4234: 4229: 4224: 4219: 4214: 4209: 4204: 4199: 4194: 4188: 4186: 4181: 4178: 4177: 4175: 4174: 4169: 4164: 4159: 4154: 4148: 4146: 4142: 4141: 4139: 4138: 4133: 4131:Superinfection 4128: 4123: 4118: 4113: 4108: 4102: 4100: 4099:General topics 4096: 4095: 4090: 4088: 4087: 4080: 4073: 4065: 4059: 4058: 4052: 4046: 4038: 4037:External links 4035: 4032: 4031: 4001: 3966: 3936: 3906: 3876: 3827: 3796: 3760: 3723: 3697: 3666: 3610: 3599:on 3 July 2020 3584: 3512: 3475: 3460:(in Persian). 3445: 3409: 3391:Times of Malta 3376: 3344: 3311: 3278: 3248: 3218: 3188: 3158: 3127:(6): 821–823. 3107: 3075: 3049: 3019: 2989: 2959: 2929: 2907: 2877: 2850: 2820: 2771: 2760:on 5 June 2010 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StatPearls. 1237: 1207: 1206: 1204: 1201: 1161:Main article: 1158: 1155: 1144: 1141: 1061: 1058: 1053: 1050: 1045: 1042: 1037: 1034: 1014: 1011: 991: 988: 976: 973: 961:Main article: 958: 955: 950: 947: 846:matrix protein 785:Main article: 782: 779: 759:Main article: 756: 753: 741:Main article: 738: 735: 688:cytokine storm 680:Pomona College 645:Main article: 642: 639: 637: 634: 613: 610: 570:negative-sense 559:viral envelope 522: 521: 519: 518: 511: 504: 496: 493: 492: 489: 488: 483: 478: 473: 468: 462: 459: 458: 455: 454: 451: 450: 445: 440: 435: 430: 425: 420: 418:1976 swine flu 414: 409: 408: 405: 404: 401: 400: 398:2009 swine flu 395: 390: 385: 380: 375: 369: 364: 363: 360: 359: 356: 355: 350: 345: 340: 335: 330: 325: 320: 314: 309: 308: 305: 304: 301: 300: 295: 290: 289: 288: 277: 272: 271: 268: 267: 264: 263: 262: 261: 259:A/H1N1 subtype 251: 246: 241: 240: 239: 237:A/H5N1 subtype 228: 223: 222: 219: 218: 210: 209: 199: 198: 197: 196: 188: 187: 183: 182: 177: 175: 171: 170: 163: 161: 157: 156: 149: 145: 144: 137: 133: 132: 125: 121: 120: 113: 109: 108: 101: 97: 96: 89: 85: 84: 77: 70: 69: 64: 60: 59: 46: 45: 37: 36: 15: 13: 10: 9: 6: 4: 3: 2: 4999: 4988: 4985: 4984: 4982: 4965: 4960: 4956: 4951: 4945: 4941: 4936: 4930: 4926: 4925: 4923: 4921: 4917: 4913: 4908: 4901: 4896: 4891: 4887: 4874: 4871: 4869: 4866: 4864: 4861: 4860: 4858: 4854: 4848: 4845: 4843: 4840: 4838: 4835: 4833: 4830: 4828: 4825: 4823: 4820: 4818: 4817:Bronchiolitis 4815: 4813: 4810: 4809: 4807: 4805: 4804:Complications 4801: 4791: 4790:Fujian (H5N1) 4788: 4786: 4783: 4782: 4780: 4776: 4770: 4767: 4763: 4760: 4759: 4758: 4755: 4753: 4750: 4748: 4745: 4744: 4742: 4738: 4735: 4731: 4721: 4718: 4714: 4711: 4710: 4709: 4706: 4705: 4703: 4701: 4697: 4691: 4688: 4686: 4683: 4681: 4678: 4676: 4673: 4671: 4668: 4666: 4663: 4661: 4658: 4656: 4653: 4652: 4650: 4648: 4644: 4641: 4636:Pandemics and 4633: 4623: 4620: 4618: 4615: 4613: 4610: 4608: 4605: 4604: 4602: 4600: 4596: 4590: 4587: 4585: 4582: 4580: 4574: 4570: 4567: 4565: 4562: 4560: 4557: 4555: 4552: 4551: 4550: 4547: 4543: 4540: 4538: 4535: 4534: 4533: 4530: 4529: 4527: 4525: 4521: 4518: 4516: 4512: 4502: 4499: 4498: 4496: 4492: 4489: 4487: 4483: 4473: 4470: 4468: 4467:Social impact 4465: 4463: 4460: 4456: 4453: 4452: 4451: 4448: 4446: 4445:Global spread 4443: 4441: 4438: 4436: 4433: 4432: 4430: 4426: 4420: 4417: 4415: 4412: 4410: 4407: 4405: 4402: 4400: 4397: 4396: 4394: 4390: 4387: 4385: 4381: 4371: 4368: 4367: 4365: 4361: 4355: 4352: 4350: 4347: 4345: 4342: 4341: 4339: 4337: 4333: 4330: 4328: 4324: 4318: 4315: 4313: 4310: 4308: 4305: 4303: 4300: 4298: 4295: 4293: 4290: 4288: 4285: 4283: 4280: 4278: 4275: 4273: 4270: 4268: 4265: 4263: 4260: 4258: 4255: 4253: 4250: 4248: 4245: 4243: 4240: 4238: 4235: 4233: 4230: 4228: 4225: 4223: 4220: 4218: 4215: 4213: 4210: 4208: 4205: 4203: 4200: 4198: 4195: 4193: 4190: 4189: 4187: 4179: 4173: 4170: 4168: 4165: 4163: 4160: 4158: 4155: 4153: 4150: 4149: 4147: 4143: 4137: 4134: 4132: 4129: 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Irrawaddy 3322: 3315: 3312: 3299: 3295: 3294: 3289: 3282: 3279: 3266: 3262: 3258: 3252: 3249: 3236: 3232: 3228: 3222: 3219: 3206: 3202: 3198: 3192: 3189: 3176: 3172: 3168: 3162: 3159: 3154: 3150: 3145: 3140: 3135: 3130: 3126: 3122: 3118: 3111: 3108: 3095: 3091: 3090: 3085: 3079: 3076: 3063: 3059: 3053: 3050: 3037: 3033: 3029: 3023: 3020: 3007: 3003: 3002:Cadenaser.com 2999: 2993: 2990: 2977: 2973: 2969: 2963: 2960: 2947: 2943: 2939: 2933: 2930: 2925: 2921: 2917: 2911: 2908: 2895: 2891: 2887: 2881: 2878: 2865: 2861: 2854: 2851: 2838: 2834: 2830: 2824: 2821: 2816: 2812: 2807: 2802: 2798: 2794: 2791:(9): 616–17. 2790: 2786: 2782: 2775: 2772: 2759: 2755: 2751: 2745: 2742: 2729: 2725: 2721: 2715: 2712: 2700:on 2 May 2009 2699: 2695: 2689: 2686: 2673: 2669: 2665: 2661: 2654: 2651: 2646: 2642: 2637: 2632: 2628: 2624: 2620: 2616: 2612: 2605: 2602: 2589: 2585: 2581: 2580: 2574: 2568: 2565: 2552: 2548: 2542: 2539: 2534: 2530: 2524: 2521: 2517: 2505: 2501: 2495: 2492: 2480:on 7 May 2009 2479: 2475: 2471: 2465: 2462: 2449: 2445: 2441: 2435: 2432: 2427: 2423: 2419: 2412: 2409: 2393: 2386: 2380: 2377: 2364: 2360: 2356: 2350: 2348: 2344: 2331: 2327: 2323: 2319: 2315: 2311: 2304: 2301: 2288: 2284: 2277: 2274: 2261: 2257: 2251: 2248: 2235: 2231: 2227: 2221: 2218: 2205: 2201: 2195: 2192: 2187: 2183: 2182:Time magazine 2179: 2173: 2170: 2165: 2161: 2159: 2151: 2148: 2143: 2139: 2134: 2129: 2124: 2119: 2115: 2111: 2108:(6): e11184. 2107: 2103: 2099: 2092: 2089: 2084: 2080: 2076: 2072: 2068: 2064: 2060: 2056: 2052: 2048: 2041: 2038: 2025: 2021: 2015: 2012: 1999: 1995: 1989: 1986: 1973: 1969: 1965: 1959: 1956: 1951: 1947: 1942: 1937: 1933: 1929: 1925: 1921: 1917: 1910: 1907: 1894: 1890: 1884: 1880: 1879: 1874: 1868: 1865: 1860: 1856: 1852: 1848: 1843: 1838: 1834: 1830: 1826: 1819: 1816: 1811: 1807: 1803: 1799: 1795: 1791: 1787: 1783: 1775: 1772: 1767: 1763: 1758: 1753: 1749: 1745: 1741: 1737: 1733: 1729: 1725: 1718: 1715: 1710: 1706: 1702: 1698: 1693: 1688: 1684: 1680: 1676: 1672: 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907: 903: 899: 898: 892: 890: 886: 882: 881:Hong Kong flu 878: 873: 871: 867: 862: 858: 854: 849: 847: 843: 842:neuraminidase 839: 838:hemagglutinin 834: 832: 828: 824: 820: 815: 811: 804: 799: 794: 788: 780: 778: 776: 772: 768: 762: 754: 752: 750: 744: 736: 734: 732: 728: 724: 719: 716: 712: 708: 704: 703:immune system 700: 696: 693: 689: 681: 676: 672: 670: 666: 662: 658: 654: 648: 640: 635: 633: 631: 626: 624: 618: 611: 609: 607: 603: 599: 594: 592: 588: 584: 579: 575: 571: 566: 564: 560: 556: 552: 548: 544: 540: 536: 532: 528: 517: 512: 510: 505: 503: 498: 497: 495: 494: 487: 484: 482: 479: 477: 474: 472: 469: 467: 464: 463: 457: 456: 449: 446: 444: 441: 439: 436: 434: 431: 429: 426: 424: 421: 419: 416: 415: 412: 407: 406: 399: 396: 394: 391: 389: 386: 384: 381: 379: 376: 374: 371: 370: 367: 362: 361: 354: 351: 349: 346: 344: 341: 339: 336: 334: 331: 329: 326: 324: 321: 319: 316: 315: 312: 307: 306: 299: 296: 294: 291: 287: 284: 283: 282: 281:2009 pandemic 279: 278: 275: 270: 269: 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Index

Pandemic H1N1/09 virus
Spanish flu

Virus classification
Edit this classification
Virus
Riboviria
Orthornavirae
Negarnaviricota
Insthoviricetes
Articulavirales
Orthomyxoviridae
Alphainfluenzavirus
Influenza A virus
Pandemic H1N1/09 virus
Influenza (flu)
H1N1 virus
Types
Avian
A/H5N1 subtype
Canine
Equine
Swine
A/H1N1 subtype
Vaccines
2009 pandemic
Pandemrix
Live attenuated
Seasonal flu vaccine brands
Treatment

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