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Injection (medicine)

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3858: 279:, allowing a substance to be delivered directly into the bloodstream. An intravenous injection provides the quickest onset of the desired effects because the substance immediately enters the blood, and is quickly circulated to the rest of the body. Because the substance is administered directly into the bloodstream, there is no delay in the onset of effects due to the absorption of the substance into the bloodstream. This type of injection is the most common and is used frequently for administration of medications in an inpatient setting. 444:, and is generally only considered once multiple attempts at intravenous access have failed, as it is a more invasive method of administration than an IV. With the exception of occasional differences in the accuracy of blood tests when drawn from an intraosseous line, it is considered to be equivalent in efficacy to IV access. It is most commonly used in emergency situations where there is not ample time to repeatedly attempt to obtain IV access, or in younger people for whom obtaining IV access is more difficult. 416:, the layer of skin above the subcutaneous fat layer, but below the epidermis or top layer. An intradermal injection is administered with the needle placed almost flat against the skin, at a 5 to 15 degree angle. Absorption from an intradermal injection takes longer than when the injection is given intravenously, intramuscularly, or subcutaneously. For this reason, few medications are administered intradermally. Intradermal injections are most commonly used for sensitivity tests, including 3492: 221: 398: 38: 736:
medication, instead a new needle should be used each time the container must be pierced. Aseptic technique should always be practiced when administering injections. This includes the use of barriers including gloves, gowns, and masks for health care providers. It also requires the use of a new, sterile needle, syringe and other equipment for each injection, as well as proper training to avoid touching non-sterile surfaces with sterile items.
3965: 204:, especially in less-developed countries. To combat this, safety syringes exist which contain features to prevent accidental needlestick injury and reuse of the syringe after it is used once. Furthermore, recreational drug users who use injections to administer the drugs commonly share or reuse needles after an injection. This has led to the development of needle exchange programs and safe injection sites as a 4205: 3486: 4027: 577:, that deposits a drug in a localized mass, called a depot, from which it is gradually absorbed by surrounding tissue. Such injection allows the active compound to be released in a consistent way over a long period. Depot injections are usually either oil-based or an aqueous suspension. Depot injections may be available as certain salt forms of a drug, such as 3731: 816:
may also provide medications such as naloxone, used as an antidote in opioid overdose situations, or other antidotes or emergency care. Safe injection site have been associated with lower rates of death from overdose, less ambulance calls, and lower rates of new HIV infections from unsafe needle practices.
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and needle exchange programs, which may be offered separately or colocated. These programs may provide new sterile needles upon request to mitigate infection risk, and some also provide access to on-site clinicians and emergency medical care if it becomes required. In the event of an overdose, a site
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Proper needle use is important to perform injections safely, which includes the use of a new, sterile needle for each injection. This is partly because needles get duller with each use and partly because reusing needles increases risk of infection. Needles should not be shared between people, as this
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An intraosseous injection or infusion is the act of administering medication through a needle inserted into the bone marrow of a large bone. This method of administration is only used when it is not possible to maintain access through a less invasive method such as an intravenous line, either due to
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Many injections are designed to administer a medication which has an effect throughout the body. Systemic injections may be used when a person cannot take medicine by mouth, or when the medication itself would not be absorbed into circulation from the gastrointestinal tract. Medications administered
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pathogens. The practice of using the same needle for multiple people increases the risk of disease transmission between people sharing the same medication. In addition, it is not recommended to reuse a used needle to pierce a medication bag, bottle, or ampule designed to provide multiple doses of a
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of the skin while giving the injection. Some studies also suggest that forced coughing during an injection stimulates a transient rise in blood pressure which inhibits the perception of pain. For some injections, especially deeper injections, a local anesthetic is given. When giving an injection to
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The act of piercing the skin with a needle, while necessary for an injection, also may cause localized pain. The most common technique to reduce the pain of an injection is simply to distract the person receiving the injection. Pain may be dampened by prior application of ice or topical anesthetic,
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and allergy tests, as well as sensitivity tests to medications a person has never had before. The reactions caused by tests which use intradermal injection are more easily seen due to the location of the injection, and when positive will present as a red or swollen area. Common sites of intradermal
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are inadvertently introduced into the tissues of the body during an injection. Contamination of the needle used for injection, or reuse of needles for injections in multiple people, can lead to transmission of hepatitis B and C, HIV, and other bloodstream infections. Injection drug users have high
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Subcutaneous injections, abbreviated as SC or sub-Q, consist of injecting a substance via a needle under the skin. Absorption of the medicine from this tissue is slower than in an intramuscular injection. Since the needle does not need to penetrate to the level of the muscle, a thinner and shorter
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before, during, or after an injection. To prevent the localized pain that occurs with injections the injection site may be numbed or cooled before injection and the person receiving the injection may be distracted by a conversation or similar means. To reduce the risk of infection from injections,
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filled should be sealed properly to prevent re-opening or accidental opening during transportation. Some locations offer publicly accessible "sharps take-back" programs where a sharps container may be dropped off to a public location for safe disposal at no fee to the person. In addition, some
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and needle may be used. The most basic reuse prevention device is an "auto-disable" plunger, which once pressed past a certain point will no longer retract. Another common safety feature is an auto-retractable needle, where the needle is spring-loaded and either retracts into the syringe after
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Injections are classified in multiple ways, including the type of tissue being injected into, the location in the body the injection is designed to produce effects, and the duration of the effects. Regardless of classification, injections require a puncture to be made, thus requiring
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Injections into the skin and soft tissue generally do not cause any permanent damage, and the puncture heals within a few days. However, in some cases, injections can cause long-term adverse effects. Intravenous and intramuscular injections may cause damage to a nerve, leading to
534:, and the effects may last for up to 6 months following a single injection. Hyaluronic acid injection is used to supplement the body's natural synovial fluid and decrease the friction and stiffness of the joint. Administering a joint injection generally involves the use of an 607:
Injections may also be used to insert a solid or semi-solid into the body which releases a medication slowly over time. These implants are generally designed to be temporary, replaceable, and ultimately removed at the end of their use or when replaced. There are multiple
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to the body, and thus may cause localized pain or infection. The occurrence of these side effects varies based on injection location, the substance injected, needle gauge, procedure, and individual sensitivity. Rarely, more serious side effects including gangrene,
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Injections may be performed into specific parts of the body when the medication's effects are desired to be limited to a specific location, or where systemic administration would produce undesirable side effects which may be avoided by a more directed injection.
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Long-acting injectable (LAI) formulations of medications are not intended to have a rapid effect, but instead release a medication at a predictable rate continuously over a period of time. Both depot injections and solid injectable implants are used to increase
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species, also called stinging trees, use their trichomes to inject a mix of neurotoxic peptides which causes a reaction similar to the stinging nettle, but also may result in recurring flares for a much longer period after the injection. While some plants have
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As of 2024, at least ten countries currently offer safe injection sites, including Australia, Canada, the United States, Denmark, France, Germany, Luxembourg, The Netherlands, Norway, Spain and Switzerland. In total, there are at least 120 sites operating.
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needle can be used. Subcutaneous injections may be administered in the fatty tissue behind the upper arm, in the abdomen, or in the thigh. Certain medications, including epinephrine, may be used either intramuscularly or subcutaneously. Others, such as
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rates of unsafe needle use including sharing needles between people. The spread of HIV, Hepatitis B, and Hepatitis C from injection drug use is a common health problem, in particular contributing to over half of new HIV cases in North America in 1994.
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for the treatment of opioid dependence is also available as an injectable implant. Various materials can be used to manufacture implants including biodegradable polymers, osmotic release systems, and small spheres which dissolve in the body.
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Other infections may occur when pathogens enter the body through the injection site, most commonly due to improper cleaning of the site before injection. Infections occurring in this way are mainly localized infections, including
522:(or intra-articular injection) may be administered into the articular space surrounding the joint. These injections can range from a one-time dose of a steroid to help with pain and inflammation to complete replacement of the 436:
frequent loss of access due to a collapsed vessel, or due to the difficulty of finding a suitable vein to use in the first place. Intraosseous access is commonly obtained by inserting a needle into the bone marrow of the
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Fischer B, Murphy Y, Rudzinski K, MacPherson D (January 2016). "Illicit drug use and harms, and related interventions and policy in Canada: A narrative review of select key indicators and developments since 2000".
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pharmaceutical and independent companies provide mail-back sharps programs, sometimes for an additional fee. In the United States, there are 39 states that offer programs to provide needle or syringe exchange.
464:, may be used to treat conditions which are localized to the penis. They can be self-administered for erectile dysfunction prior to intercourse or used in a healthcare setting for emergency treatment for a 3403: 286:
and may provide all or only part of a person's nutritional requirements. Parenteral nutrition may be pre-mixed or customized for a person's specific needs. Intravenous injections may also be used for
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recommends the use of single-use syringes with both reuse prevention devices and a needlestick injury prevention mechanism for all injections to prevent accidental injury and disease transmission.
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drop to dilate the pupil. They are commonly used in lieu of systemic administration to both increase the concentrations present in the eye, as well as avoid systemic side effects of medications.
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should be followed to clean the injection site before administration. If needles or syringes are reused between people, or if an accidental needlestick occurs, there is a risk of transmission of
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injection, or into a plastic sheath on the side of the syringe. Other safety syringes have an attached sheath which may be moved to cover the end of the needle after the injection is given. The
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after attaching to prevent blood from clotting during feeding. This property of leeches has been used historically as a natural form of anticoagulation therapy, as well as for the use of
511:. An intravitreal injection is performed by injecting a medication through the pupil into the vitreous humor core of the eye after applying a local anesthetic drop to numb the eye and a 803:
The aspiration is the technique of pulling back on the plunger of a syringe prior to the actual injection. If blood flows into the syringe it signals that a blood vessel has been hit.
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muscles. Medical professionals are trained to give IM injections, but people who are not medical professionals can also be trained to administer medications like epinephrine using an
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is a type of fish which has venomous spines covering its fins and gills and injects a venom consisting of proteins which cause a severe local reaction which is not life-threatening.
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Des Jarlais DC, Friedman SR, Stoneburner RL (January 1988). "HIV infection and intravenous drug use: critical issues in transmission dynamics, infection outcomes, and prevention".
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may also occur when a medication intended to be injected into a vein is inadvertently injected into surrounding tissues. Those who are afraid of needles may also experience
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environments and procedures to minimize the risk of introducing pathogens into the body. All injections are considered forms of parenteral administration, which avoids the
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Cu, K., Bansal, R., Mitragotri, S. et al. Delivery Strategies for Skin: Comparison of Nanoliter Jets, Needles and Topical Solutions. Ann Biomed Eng 48, 2028–2039 (2020).
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measure, which may provide new, sterile syringes and needles to discourage the reuse of syringes and needles. Used needles should ideally be placed in a purpose-made
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Another use for intravenous injections includes for the administration of nutrition to people who cannot get nutrition through the digestive tract. This is termed
97:. There are many types of injection, which are generally named after the body tissue the injection is administered into. This includes common injections such as 538:
or other live imaging technique to ensure the injection is administered in the desired location, as well as to reduce the risk of damaging surrounding tissues.
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Bagella S, Filigheddu R, Benesperi R, Giordani P, Minuto L, Viciani D, et al. (2 January 2019). "Thorn, spine and prickle patterns in the Italian flora".
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Salonia A, Eardley I, Giuliano F, Hatzichristou D, Moncada I, Vardi Y, et al. (February 2014). "European Association of Urology Guidelines on Priapism".
2599:"Sharps injury reduction: a six-year, three-phase study comparing use of a small patient-room sharps disposal container with a larger engineered container" 164:(or one-time) dose, but can also be used for continuous drug administration. After injection, a medication may be designed to be released slowly, called a 492:. The most common adverse effects of intercavernosal injections include fibrosis and pain, as well as hematomas or bruising around the injection site. 1640:
Duncan C, Omran GJ, Teh J, Davis NF, Bolton DM, Lawrentschuk N (June 2019). "Erectile dysfunction: a global review of intracavernosal injectables".
957:, these generally are not used for injection of any substance, but instead it is the act of piercing the skin which causes them to be a deterrent. 739:
To help prevent accidental needlestick injury to the person administering the injection, and prevent reuse of the syringe for another injection, a
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drug administration; it does not involve absorption in the digestive tract. This allows the medication to be absorbed more rapidly and avoid the
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Mory RN, Mindell D, Bloom DA (July 2000). "The Leech and the Physician: Biology, Etymology, and Medical Practice with Hirudinea medicinalis".
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to reduce the risk of accidental needle sticks and exposure to other people. In addition, a new sharps container should be begun once it is
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via a systemic injection will enter into blood circulation, either directly or indirectly, and thus will have an effect on the entire body.
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marketed for different active ingredients, as well as differing duration of action - most of these are injected under the skin. A form of
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WHO guideline on the use of safety-engineered syringes for intramuscular, intradermal and subcutaneous injections in health care settings
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Schwamburger NT, Hancock RH, Chong CH, Hartup GR, Vandewalle KS (2012). "The rate of adverse events during IV conscious sedation".
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use their spinal blade to inject a protein-based venom which causes localized cell death but is not generally life-threatening.
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Due to the prevalence of unsafe injection practices, especially among injection drug users, many locations have begun offering
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which is safe and resistant to puncture. Some locations provide free disposal programs for such containers for their citizens.
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Plants may use a form of injection which is passive, where the injectee pushes themselves against the stationary needle. The
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Novel injection techniques include drug diffusion within the skin using needle-free micro-jet injection (NFI) technology.
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Pieper B, Kirsner RS, Templin TN, Birk TJ (October 2007). "Injection drug use: an understudied cause of venous disease".
4312: 4274: 3617: 3433: 954: 4226: 2278: 586: 500: 325: 930:, or stinging hairs, over its leaves and stems which are used to inject a mix of irritating chemicals which includes 308:, where they are quickly absorbed by the blood vessels into systemic circulation. Common injection sites include the 1205:"Standardized versusindividually customized parenteral nutrition solutions: a comparison ofserum electrolyte values" 4254: 3823: 31: 4302: 4231: 3818: 3765: 3599: 2539: 812: 792: 745: 160:, but injection does not only refer to the act of inoculation. Injections generally administer a medication as a 110: 90: 909:
species, inject protein-based venom which causes severe pain but is still not life-threatening. The bullet ant (
706:. Injections also cause localized bleeding, which may lead to a hematoma. Intravenous injections may also cause 4221: 3595: 1777: 461: 126: 122: 4249: 4292: 4259: 4058: 3890: 3622: 3543: 3470: 3412: 574: 530:. The injection of a steroid into a joint is used to reduce inflammation associated with conditions such as 457: 313: 299: 225: 102: 4287: 4241: 4183: 4089: 3956: 3563: 3437: 2073:"Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review" 1475:(7th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. pp. 749, 788. 711: 566: 341: 229: 118: 114: 98: 636:
young children or infants, they may be distracted by giving them a small amount of sweet liquid, such as
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Degenhardt L, Whiteford HA, Ferrari AJ, Baxter AJ, Charlson FJ, Hall WD, et al. (November 2013).
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Yaftali, Nina A.; Weber, Kathleen (1 January 2019). "Corticosteroids and Hyaluronic Acid Injections".
840:, toxic proteins, and cytotoxic enzymes. Different species of snakes inject different formulations of 480:
are ineffective or contraindicated. Other medications may also be administered in this way, including
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each year. Of these, 95% are used in curative care or as treatment for a condition, 3% are to provide
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Injections are among the most common health care procedures, with at least 16 billion administered in
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Courtney P, Doherty M (April 2013). "Joint aspiration and injection and synovial fluid analysis".
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Sepah, Y.; Samad, L.; Altaf, A.; Halim, M. S.; Rajagopalan, N.; Javed Khan, A. (1 March 2017).
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Gilding EK, Jami S, Deuis JR, Israel MR, Harvey PJ, Poth AG, et al. (1 September 2020).
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Touchard A, Aili S, Fox E, Escoubas P, Orivel J, Nicholson G, et al. (20 January 2016).
1891: 351:, are almost exclusively injected subcutaneously. Live or attenuated vaccines, including the 4053: 3337: 3292: 3282: 3233: 3192: 3179:
Szolajska E, Poznanski J, Ferber ML, Michalik J, Gout E, Fender P, et al. (June 2004).
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use a stinger located in their hind region to inject a venom consisting of proteins such as
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report open burning of disposed or used syringes. This practice is considered unsafe by the
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Harrison D, Stevens B, Bueno M, Yamada J, Adams-Webber T, Beyene J, Ohlsson A (June 2010).
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Schoener EP, Hopper JA, Pierre JD (September 2002). "Injection drug use in North America".
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FDA Center for Drug Evaluation and Research Data Standards Manual: Route of Administration
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Harrison D, Reszel J, Bueno M, Sampson M, Shah VS, Taddio A, et al. (October 2016).
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which would potentially affect a medication absorbed through the gastrointestinal tract.
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Many species of animals use injections for self-defence or catching prey. This includes
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in an emergency. Some depot injections are also administered intramuscularly, including
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solution, or be comforted by breastfeeding during the injection, which reduces crying.
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Ramdhan RC, Simonds EA, Wilson C, Loukas M, Oskouian RJ, Tubbs RS (31 January 2018).
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Handbook of Basic Pharmacokinetics … Including Clinical Applications, Seventh Edition
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Intradermal injections, abbreviated as ID, consist of a substance delivered into the
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among others. In addition to medications, most inactivated vaccines, including the
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which is characterized by a stinging, burning, and itching sensation in the area.
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EpiPen/EpiPen Jr (epinephrine) . Morgantown, WV: Mylan Specialty LP; August 2018.
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into the skin with their fangs. Common substances present in snake venom include
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Petitpas F, Guenezan J, Vendeuvre T, Scepi M, Oriot D, Mimoz O (December 2016).
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to therapy by reducing the frequency at which a person must take a medication.
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which causes extreme pain, fever, and cold sweats, and may cause arrhythmias.
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Intramuscular injections, abbreviated as IM, deliver a substance deep into a
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Intravenous injections, abbreviated as IV, involve inserting a needle into a
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Polania Gutierrez JJ, Munakomi S (January 2020). "Intramuscular Injection".
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Doshi RR, Bakri SJ, Fung AE (May 2011). "Intravitreal Injection Technique".
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with an injection to either remove blood from the penis or to administer a
17: 3263:"Neurotoxic peptides from the venom of the giant Australian stinging tree" 3095: 3037: 2934: 2485: 2263: 184:, also called needle phobia, is also common and may result in anxiety and 4318: 4307: 4099: 4079: 4074: 4048: 3992: 3885: 3875: 3870: 3627: 3573: 3538: 3523: 3465: 3046: 2851: 2838:
Gold BS, Dart RC, Barish RA (1 August 2002). "Bites of venomous snakes".
2114:"Breastfeeding for procedural pain in infants beyond the neonatal period" 868: 682: 661: 495:
Medications may also be administered by injecting them directly into the
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Hamilton JG (August 1995). "Needle phobia: a neglected diagnosis".
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Warrell DA (March 2019). "Venomous Bites, Stings, and Poisoning".
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Fundamentals of nursing : the art and science of nursing care
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medication to reduce the erection. Intracavernosal injections of
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This article is about the medical procedure. For other uses, see
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Rivas, David Fernandez; Galvez, Loreto Alejandra Oyarte (2020).
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Usichenko TI, Pavlovic D, Foellner S, Wendt M (February 2004).
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Substance Use Disorders: A Guide for the Primary Care Provider
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Hayes EM, Cohen KR, Pinard BE, Lauletta J, Ruggiero R (2000).
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Webster J, Osborne S, Rickard CM, Marsh N (23 January 2019).
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which include compounds which produce minor pain such as the
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or paralysis. Intramuscular injections may cause fibrosis or
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da Silva NJ, Ferreira KR, Pinto RN, Aird SD (18 June 2015).
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Joanne, Garside; Stephen, Prescott; Susan, Shaw (May 2016).
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Used needles should be disposed of in specifically designed
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at the sight of a needle, or before or after an injection.
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Fan J, de Lannoy IA (January 2014). "Pharmacokinetics".
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may be used by people for whom other treatments such as
1919:"Complications of Subcutaneous Contraception: A Review" 200:
Unsafe injection practices contribute to the spread of
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Revista do Instituto de Medicina Tropical de São Paulo
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Haddad Junior V, Cardoso JL, Moraes RH (August 2005).
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salts or esters. Examples of depot injections include
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injections, as well as less common injections such as
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National Institute of Allergy and Infectious Diseases
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St Charles M, Lynch P, Graham C, Minshall ME (2009).
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as a treatment for various ailments. Some species of
77:) is the act of administering a liquid, especially a 1119:. The American Pharmacists Association. 2009-01-01. 915:) injects a venom which contains a neurotoxin named 41:
A syringe being prepared for injection of medication
4268: 4240: 4212: 4165: 4132: 4013: 3951: 3904: 3840: 3790: 3746: 3706: 3692: 3657: 3608: 3586: 3499: 3446: 3432: 3423: 2751:"Does evidence support supervised injection sites?" 1896:. Springer International Publishing. pp. 88–. 1803:Best Practice & Research Clinical Rheumatology 1391:. Centers for Disease Control and Prevention (CDC) 224:Needle insertion angles for 4 types of injection: 2017: 2015: 81:, into a person's body using a needle (usually a 1318:Injection (Intramuscular): Clinician Information 518:When an effect is only required in one joint, a 3079:"The Biochemical Toxin Arsenal from Ant Venoms" 2749:Ng J, Sutherland C, Kolber MR (November 2017). 421:injections include the forearm and lower back. 1469:Taylor CR, Lillis C, LeMone P, Lynn P (2011). 1387:Wolicki E, Weinbaum C, Weaver D (2017-10-04). 1364:. United States Food and Drug Administration. 1115:"Chapter 6. Absorption/Transport Mechanisms". 3397: 1464: 1462: 1460: 863:also utilize injection for various purposes. 8: 1862: 1860: 903:subfamily. Other species of ants, including 2875:Infectious Disease Clinics of North America 2394:The Cochrane Database of Systematic Reviews 2118:The Cochrane Database of Systematic Reviews 1968:Rosenthal RN, Goradia VV (28 August 2017). 1681: 1679: 1248:Infectious Disease Clinics of North America 565:A depot injection is an injection, usually 4162: 3703: 3605: 3443: 3429: 3404: 3390: 3382: 2571:https://doi.org/10.1007/s10439-019-02383-1 2497: 2495: 1635: 1633: 1496: 1494: 1492: 290:when a rapid onset of effects is desired. 168:, which can produce long-lasting effects. 3296: 3286: 3237: 3222:"Mechanism of action of stinging nettles" 3196: 3155: 3145: 3104: 3094: 3045: 3000: 2975:Jun G, Guan SM, Sun W, Fu H (June 2016). 2943: 2933: 2766: 2725: 2715: 2622: 2421: 2364: 2353:Journal of International Medical Research 2137: 2088: 2039: 1995: 1985: 1944: 1934: 1729: 1727: 1725: 1528: 1518: 1091: 2597:Grimmond T, Naisoro W (September 2014). 2527: 2525: 2523: 2209:The International Journal on Drug Policy 1044: 1042: 1040: 171:An injection necessarily causes a small 3226:Wilderness & Environmental Medicine 2347:Jung Kim H, Hyun Park S (August 2014). 1362:"Drugs@FDA: FDA Approved Drug Products" 1012: 332:vaccine, are given as an IM injection. 89:. An injection is considered a form of 1834: 1832: 1407: 1405: 1150: 1140: 899:, which is injected by members of the 2503:"Background | Injection Safety | CDC" 1890:H. Thomas Milhorn (17 October 2017). 1368:from the original on 16 November 2016 49:(often and usually referred to as a " 7: 1974:Drug Design, Development and Therapy 1241: 1239: 405:sensitivity test being administered 383:) are also injected subcutaneously. 156:is sometimes used synonymously with 3761:Heated humidified high-flow therapy 2840:The New England Journal of Medicine 1841:Long acting injections and implants 27:Method of medication administration 3220:Cummings AJ, Olsen M (June 2011). 2041:10.1213/01.ANE.0000094983.16741.AF 1218:(2): 78–80, 83, 87. Archived from 773:full. A sharps container which is 25: 2819:National Harm Reduction Coalition 2815:"Supervised Consumption Services" 2791:"Supervised Consumption Services" 1778:"MSK Ultrasound Guided Injection" 4203: 3729: 3490: 3484: 3198:10.1111/j.1432-1033.2004.04128.x 3185:European Journal of Biochemistry 2349:"Sciatic nerve injection injury" 2077:Archives of Disease in Childhood 1338:. April 23, 2015. Archived from 1093:10.1111/j.1524-4733.2008.00478.x 942:. This sting produces a form of 3147:10.1590/S0036-46652005000400012 2603:Journal of Infection Prevention 2034:(2): 343–5, table of contents. 731:increases risk of transmitting 2474:The Journal of Family Practice 2406:10.1002/14651858.CD007798.pub5 2244:Reviews of Infectious Diseases 2130:10.1002/14651858.cd011248.pub2 1839:Wright JC, Burgess DJ (2012). 1413:"Subcutaneous (SQ) injections" 1320:. The Joanna Briggs Institute. 499:of the eye. This is termed an 180:, and nerve damage may occur. 1: 3529:Effervescent powder or tablet 3342:10.1080/11263504.2018.1474961 2717:10.12688/f1000research.1113.3 2295:10.1016/S0140-6736(13)61530-5 1867:Carpenter J, Wong KK (2018). 1260:10.1016/S0891-5520(02)00010-7 832:which inject venom when they 4313:Patient-controlled analgesia 3618:Orally disintegrating tablet 3366:Information about injections 2221:10.1016/j.drugpo.2015.08.007 1700:10.3109/08820538.2010.541318 1616:10.1016/j.eururo.2013.11.008 1295:10.1001/archderm.143.10.1305 955:thorns, spines, and prickles 2654:www.nationwidechildrens.org 2650:"Sharps Containers at Home" 1444:"Administer the Vaccine(s)" 1056:. World Health Organization 848:and potentially death. The 587:medroxyprogesterone acetate 326:medroxyprogesterone acetate 197:such as HIV and hepatitis. 4360: 3824:Relative analgesia machine 1843:. New York, NY: Springer. 1815:10.1016/j.berh.2013.02.005 1736:Clinics in Sports Medicine 1654:10.1007/s00345-019-02727-5 1125:10.21019/9781582121260.ch6 813:supervised injection sites 600: 558: 428: 390: 339: 297: 268: 29: 4201: 3727: 3482: 3239:10.1016/j.wem.2011.01.001 2993:10.1007/s12264-016-0024-y 2887:10.1016/j.idc.2018.10.001 2755:Canadian Family Physician 2540:World Health Organization 1748:10.1016/j.csm.2018.08.006 1688:Seminars in Ophthalmology 1520:10.1186/s13054-016-1277-6 1182:10.1016/j.bcp.2013.09.007 793:World Health Organization 746:World Health Organization 675:skin structure infections 462:intracavernous injections 3413:Routes of administration 3026:World Journal of Surgery 2615:10.1177/1757177414543088 2366:10.1177/0300060514531924 2256:10.1093/clinids/10.1.151 2028:Anesthesia and Analgesia 1642:World Journal of Urology 1561:Nursing in Critical Care 1170:Biochemical Pharmacology 789:industrialized countries 755:Disposal of used needles 526:with a compound such as 3939:Extra-amniotic infusion 3544:Molecular encapsulation 3476:Osmotic delivery system 3471:Time release technology 2090:10.1136/adc.2009.174227 1283:Archives of Dermatology 300:Intramuscular injection 4242:Central nervous system 4030: 3968: 3896:Mucoadhesive microdisc 3861: 3288:10.1126/sciadv.abb8828 2584:"Jet injection system" 1879:(7): 10–12, 14–19, 56. 650:needle tract infection 610:contraceptive implants 501:intravitreal injection 409: 342:Subcutaneous injection 240: 138:transitional countries 42: 4085:Transfersome vesicles 4029: 3967: 3944:Intravesical infusion 3860: 3096:10.3390/toxins8010030 3038:10.1007/s002680010141 2981:Neuroscience Bulletin 2935:10.3390/toxins7062272 654:needlestick infection 583:haloperidol decanoate 460:of the penis, termed 431:Intraosseous infusion 418:tuberculin skin tests 400: 393:Intradermal injection 250:first pass metabolism 223: 40: 4344:Injection (medicine) 3771:Metered-dose inhaler 3756:Anesthetic vaporizer 2852:10.1056/NEJMra013477 2795:Drug Policy Alliance 1054:Health Topics A to Z 1025:Cambridge dictionary 505:macular degeneration 284:parenteral nutrition 4196:Transdermal implant 4156:(into tissue/blood) 3933:Intrauterine device 3814:Anaesthetic machine 3809:Oxygen concentrator 3279:2020SciA....6.8828G 1987:10.2147/DDDT.S72543 1936:10.7759/cureus.2132 1782:R3 Medical Training 807:Society and culture 271:Intravenous therapy 202:bloodborne diseases 195:bloodborne diseases 4308:Nanocell injection 4031: 3969: 3862: 3716:Dry-powder inhaler 1873:Current Psychiatry 1573:10.1111/nicc.12163 1254:(3): 535–51, vii. 1050:"Injection safety" 987:Needlestick injury 912:Paraponera clavata 824:Plants and animals 603:Implant (medicine) 466:prolonged erection 456:Injections to the 410: 288:recreational drugs 241: 150:blood transfusions 43: 4331: 4330: 4327: 4326: 4158: 4120:Transdermal spray 4115:Transdermal patch 4105:Medicated shampoo 3836: 3835: 3832: 3831: 3819:Medical inhalants 3766:Medical inhalants 3694:Respiratory tract 3688: 3687: 3582: 3581: 2447:General Dentistry 2289:(9904): 1564–74. 1903:978-3-319-63040-3 1850:978-1-4614-0554-2 1482:978-0-7817-9383-4 1134:978-1-58212-126-0 787:Over half of non- 761:sharps containers 660:that occurs when 458:corpus cavernosum 369:varicella vaccine 191:aseptic technique 95:first pass effect 83:hypodermic needle 16:(Redirected from 4351: 4207: 4163: 4154: 3741: 3737: 3733: 3704: 3633:Sublingual drops 3606: 3494: 3488: 3444: 3430: 3406: 3399: 3392: 3383: 3354: 3353: 3330:Plant Biosystems 3325: 3319: 3318: 3300: 3290: 3273:(38): eabb8828. 3267:Science Advances 3258: 3252: 3251: 3241: 3217: 3211: 3210: 3200: 3176: 3170: 3169: 3159: 3149: 3125: 3119: 3118: 3108: 3098: 3074: 3068: 3067: 3049: 3021: 3015: 3014: 3004: 2972: 2966: 2965: 2947: 2937: 2913: 2907: 2906: 2870: 2864: 2863: 2835: 2829: 2828: 2826: 2825: 2811: 2805: 2804: 2802: 2801: 2787: 2781: 2780: 2770: 2746: 2740: 2739: 2729: 2719: 2695: 2689: 2688: 2686: 2685: 2670: 2664: 2663: 2661: 2660: 2646: 2637: 2636: 2626: 2594: 2588: 2587: 2579: 2573: 2567: 2561: 2560: 2558: 2556: 2529: 2518: 2517: 2515: 2514: 2499: 2490: 2489: 2469: 2463: 2462: 2442: 2436: 2435: 2425: 2385: 2379: 2378: 2368: 2344: 2338: 2337: 2321: 2315: 2314: 2274: 2268: 2267: 2239: 2233: 2232: 2203: 2197: 2196: 2194: 2193: 2182: 2176: 2175: 2173: 2172: 2158: 2152: 2151: 2141: 2124:(10): CD011248. 2109: 2103: 2102: 2092: 2068: 2062: 2061: 2043: 2019: 2010: 2009: 1999: 1989: 1965: 1959: 1958: 1948: 1938: 1914: 1908: 1907: 1887: 1881: 1880: 1864: 1855: 1854: 1836: 1827: 1826: 1798: 1792: 1791: 1789: 1788: 1774: 1768: 1767: 1731: 1720: 1719: 1683: 1674: 1673: 1648:(6): 1007–1014. 1637: 1628: 1627: 1604:European Urology 1599: 1593: 1592: 1558: 1549: 1543: 1542: 1532: 1522: 1498: 1487: 1486: 1466: 1455: 1454: 1452: 1451: 1440: 1434: 1431: 1425: 1424: 1422: 1420: 1409: 1400: 1399: 1397: 1396: 1384: 1378: 1377: 1375: 1373: 1358: 1352: 1351: 1349: 1347: 1328: 1322: 1321: 1313: 1307: 1306: 1278: 1272: 1271: 1243: 1234: 1233: 1231: 1230: 1224: 1209: 1200: 1194: 1193: 1165: 1159: 1158: 1152: 1148: 1146: 1138: 1112: 1106: 1105: 1095: 1071: 1065: 1064: 1062: 1061: 1046: 1035: 1034: 1032: 1031: 1017: 982:Lethal injection 891:inject forms of 782: 781: 777: 772: 771: 767: 652:, also called a 314:vastus lateralis 210:sharps container 71:Scottish English 21: 4359: 4358: 4354: 4353: 4352: 4350: 4349: 4348: 4334: 4333: 4332: 4323: 4303:Intraperitoneal 4275:musculoskeletal 4273: 4264: 4236: 4232:Intra-articular 4208: 4199: 4159: 4153: 4152: 4128: 4009: 3947: 3900: 3845: 3828: 3786: 3742: 3739: 3738: 3735: 3734: 3725: 3684: 3653: 3578: 3495: 3489: 3480: 3434:Digestive tract 3419: 3410: 3362: 3357: 3327: 3326: 3322: 3260: 3259: 3255: 3219: 3218: 3214: 3191:(11): 2127–36. 3178: 3177: 3173: 3127: 3126: 3122: 3076: 3075: 3071: 3023: 3022: 3018: 2974: 2973: 2969: 2915: 2914: 2910: 2872: 2871: 2867: 2837: 2836: 2832: 2823: 2821: 2813: 2812: 2808: 2799: 2797: 2789: 2788: 2784: 2748: 2747: 2743: 2697: 2696: 2692: 2683: 2681: 2678:nursing.usc.edu 2672: 2671: 2667: 2658: 2656: 2648: 2647: 2640: 2596: 2595: 2591: 2581: 2580: 2576: 2568: 2564: 2554: 2552: 2550: 2531: 2530: 2521: 2512: 2510: 2501: 2500: 2493: 2471: 2470: 2466: 2444: 2443: 2439: 2400:(1): CD007798. 2387: 2386: 2382: 2346: 2345: 2341: 2323: 2322: 2318: 2276: 2275: 2271: 2241: 2240: 2236: 2205: 2204: 2200: 2191: 2189: 2184: 2183: 2179: 2170: 2168: 2160: 2159: 2155: 2111: 2110: 2106: 2070: 2069: 2065: 2021: 2020: 2013: 1967: 1966: 1962: 1916: 1915: 1911: 1904: 1889: 1888: 1884: 1866: 1865: 1858: 1851: 1838: 1837: 1830: 1800: 1799: 1795: 1786: 1784: 1776: 1775: 1771: 1733: 1732: 1723: 1685: 1684: 1677: 1639: 1638: 1631: 1601: 1600: 1596: 1556: 1551: 1550: 1546: 1500: 1499: 1490: 1483: 1468: 1467: 1458: 1449: 1447: 1442: 1441: 1437: 1432: 1428: 1418: 1416: 1411: 1410: 1403: 1394: 1392: 1386: 1385: 1381: 1371: 1369: 1360: 1359: 1355: 1345: 1343: 1330: 1329: 1325: 1316:Mann E (2016). 1315: 1314: 1310: 1280: 1279: 1275: 1245: 1244: 1237: 1228: 1226: 1222: 1207: 1202: 1201: 1197: 1167: 1166: 1162: 1149: 1139: 1135: 1114: 1113: 1109: 1080:Value in Health 1073: 1072: 1068: 1059: 1057: 1048: 1047: 1038: 1029: 1027: 1019: 1018: 1014: 1010: 963: 926:plant has many 924:stinging nettle 879:peptide called 830:venomous snakes 826: 809: 801: 779: 775: 774: 769: 765: 764: 757: 728: 695: 671:skin infections 646: 628: 623: 621:Adverse effects 605: 599: 563: 561:Depot injection 557: 544: 528:hyaluronic acid 520:joint injection 478:PDE5 inhibitors 470:sympathomimetic 450: 433: 427: 395: 389: 344: 338: 302: 296: 273: 267: 258: 218: 182:Fear of needles 166:depot injection 111:intraperitoneal 35: 28: 23: 22: 15: 12: 11: 5: 4357: 4355: 4347: 4346: 4336: 4335: 4329: 4328: 4325: 4324: 4322: 4321: 4316: 4310: 4305: 4300: 4295: 4290: 4285: 4279: 4277: 4266: 4265: 4263: 4262: 4257: 4252: 4246: 4244: 4238: 4237: 4235: 4234: 4229: 4224: 4222:Intracavernous 4218: 4216: 4210: 4209: 4202: 4200: 4198: 4193: 4192: 4191: 4181: 4176: 4174: 4160: 4151: 4150: 4145: 4140: 4134: 4133: 4130: 4129: 4127: 4122: 4117: 4112: 4107: 4102: 4097: 4092: 4087: 4082: 4077: 4072: 4067: 4061: 4056: 4051: 4046: 4041: 4036: 4024: 4022: 4011: 4010: 4008: 4007: 4005:Nutrient enema 4002: 3997: 3996: 3995: 3990: 3980: 3975: 3962: 3960: 3949: 3948: 3946: 3941: 3936: 3930: 3925: 3920: 3915: 3910: 3908: 3902: 3901: 3899: 3898: 3893: 3888: 3883: 3878: 3873: 3868: 3855: 3853: 3838: 3837: 3834: 3833: 3830: 3829: 3827: 3826: 3821: 3816: 3811: 3806: 3796: 3794: 3788: 3787: 3785: 3784: 3779: 3774: 3768: 3763: 3758: 3752: 3750: 3744: 3743: 3728: 3726: 3724: 3723: 3718: 3712: 3710: 3701: 3690: 3689: 3686: 3685: 3683: 3682: 3679: 3674: 3669: 3663: 3661: 3655: 3654: 3652: 3651: 3646: 3640: 3635: 3630: 3625: 3620: 3614: 3612: 3603: 3584: 3583: 3580: 3579: 3577: 3576: 3571: 3566: 3561: 3556: 3551: 3546: 3541: 3536: 3531: 3526: 3521: 3516: 3511: 3505: 3503: 3497: 3496: 3483: 3481: 3479: 3478: 3473: 3468: 3463: 3458: 3452: 3450: 3441: 3427: 3421: 3420: 3411: 3409: 3408: 3401: 3394: 3386: 3380: 3379: 3374: 3361: 3360:External links 3358: 3356: 3355: 3336:(1): 118–133. 3320: 3253: 3212: 3171: 3140:(4): 235–238. 3120: 3069: 3032:(7): 878–883. 3016: 2987:(3): 265–272. 2967: 2928:(6): 2272–88. 2908: 2865: 2830: 2806: 2782: 2741: 2690: 2665: 2638: 2609:(5): 170–174. 2589: 2574: 2562: 2548: 2519: 2491: 2464: 2437: 2380: 2359:(4): 887–897. 2339: 2316: 2269: 2234: 2198: 2177: 2153: 2104: 2063: 2011: 1960: 1909: 1902: 1882: 1856: 1849: 1828: 1809:(2): 137–169. 1793: 1769: 1721: 1694:(3): 104–113. 1675: 1629: 1610:(2): 480–489. 1594: 1567:(3): 167–177. 1544: 1488: 1481: 1456: 1435: 1426: 1401: 1379: 1353: 1323: 1308: 1289:(10): 1305–9. 1273: 1235: 1195: 1160: 1133: 1107: 1066: 1036: 1011: 1009: 1006: 1005: 1004: 999: 997:Safety syringe 994: 992:Needle remover 989: 984: 979: 977:Injection port 974: 969: 967:Dart injection 962: 959: 875:can inject an 859:Some types of 825: 822: 808: 805: 800: 797: 756: 753: 741:safety syringe 727: 724: 694: 691: 645: 642: 627: 624: 622: 619: 601:Main article: 598: 595: 559:Main article: 556: 553: 543: 540: 532:osteoarthritis 524:synovial fluid 497:vitreous humor 449: 446: 429:Main article: 426: 423: 391:Main article: 388: 385: 377:zoster vaccine 340:Main article: 337: 334: 298:Main article: 295: 292: 269:Main article: 266: 263: 257: 254: 217: 214: 173:puncture wound 127:intracavernous 123:intraarticular 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4356: 4345: 4342: 4341: 4339: 4320: 4317: 4314: 4311: 4309: 4306: 4304: 4301: 4299: 4296: 4294: 4293:Intramuscular 4291: 4289: 4286: 4284: 4281: 4280: 4278: 4276: 4271: 4267: 4261: 4258: 4256: 4253: 4251: 4250:Intracerebral 4248: 4247: 4245: 4243: 4239: 4233: 4230: 4228: 4225: 4223: 4220: 4219: 4217: 4215: 4211: 4206: 4197: 4194: 4190: 4187: 4186: 4185: 4182: 4180: 4177: 4175: 4172: 4168: 4164: 4161: 4157: 4149: 4146: 4144: 4141: 4139: 4136: 4135: 4131: 4126: 4123: 4121: 4118: 4116: 4113: 4111: 4108: 4106: 4103: 4101: 4098: 4096: 4093: 4091: 4088: 4086: 4083: 4081: 4078: 4076: 4073: 4071: 4070:Iontophoresis 4068: 4065: 4062: 4060: 4057: 4055: 4052: 4050: 4047: 4045: 4042: 4040: 4039:Topical cream 4037: 4035: 4032: 4028: 4023: 4020: 4016: 4012: 4006: 4003: 4001: 3998: 3994: 3991: 3989: 3986: 3985: 3984: 3981: 3979: 3976: 3974: 3971: 3970: 3966: 3961: 3958: 3954: 3950: 3945: 3942: 3940: 3937: 3934: 3931: 3929: 3926: 3924: 3921: 3919: 3916: 3914: 3911: 3909: 3907: 3903: 3897: 3894: 3892: 3889: 3887: 3884: 3882: 3879: 3877: 3874: 3872: 3869: 3867: 3864: 3863: 3859: 3854: 3852: 3848: 3843: 3839: 3825: 3822: 3820: 3817: 3815: 3812: 3810: 3807: 3805: 3804:Nasal cannula 3801: 3798: 3797: 3795: 3793: 3789: 3783: 3780: 3778: 3775: 3772: 3769: 3767: 3764: 3762: 3759: 3757: 3754: 3753: 3751: 3749: 3745: 3732: 3722: 3719: 3717: 3714: 3713: 3711: 3709: 3705: 3702: 3699: 3695: 3691: 3680: 3678: 3675: 3673: 3670: 3668: 3665: 3664: 3662: 3660: 3656: 3650: 3647: 3644: 3641: 3639: 3636: 3634: 3631: 3629: 3626: 3624: 3621: 3619: 3616: 3615: 3613: 3611: 3607: 3604: 3601: 3597: 3593: 3589: 3585: 3575: 3572: 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2936: 2931: 2927: 2923: 2919: 2912: 2909: 2904: 2900: 2896: 2892: 2888: 2884: 2880: 2876: 2869: 2866: 2861: 2857: 2853: 2849: 2846:(5): 347–56. 2845: 2841: 2834: 2831: 2820: 2816: 2810: 2807: 2796: 2792: 2786: 2783: 2778: 2774: 2769: 2764: 2760: 2756: 2752: 2745: 2742: 2737: 2733: 2728: 2723: 2718: 2713: 2709: 2705: 2704:F1000Research 2701: 2694: 2691: 2679: 2675: 2669: 2666: 2655: 2651: 2645: 2643: 2639: 2634: 2630: 2625: 2620: 2616: 2612: 2608: 2604: 2600: 2593: 2590: 2585: 2578: 2575: 2572: 2566: 2563: 2551: 2549:9789241549820 2545: 2541: 2537: 2536: 2528: 2526: 2524: 2520: 2508: 2504: 2498: 2496: 2492: 2487: 2483: 2480:(2): 169–75. 2479: 2475: 2468: 2465: 2460: 2456: 2453:(5): e341-4. 2452: 2448: 2441: 2438: 2433: 2429: 2424: 2419: 2415: 2411: 2407: 2403: 2399: 2395: 2391: 2384: 2381: 2376: 2372: 2367: 2362: 2358: 2354: 2350: 2343: 2340: 2335: 2331: 2327: 2320: 2317: 2312: 2308: 2304: 2300: 2296: 2292: 2288: 2284: 2280: 2273: 2270: 2265: 2261: 2257: 2253: 2249: 2245: 2238: 2235: 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1507:Critical Care 1504: 1497: 1495: 1493: 1489: 1484: 1478: 1474: 1473: 1465: 1463: 1461: 1457: 1445: 1439: 1436: 1430: 1427: 1414: 1408: 1406: 1402: 1390: 1383: 1380: 1367: 1363: 1357: 1354: 1342:on 4 May 2015 1341: 1337: 1333: 1332:"Anaphylaxis" 1327: 1324: 1319: 1312: 1309: 1304: 1300: 1296: 1292: 1288: 1284: 1277: 1274: 1269: 1265: 1261: 1257: 1253: 1249: 1242: 1240: 1236: 1225:on 2011-07-15 1221: 1217: 1213: 1206: 1199: 1196: 1191: 1187: 1183: 1179: 1176:(1): 93–120. 1175: 1171: 1164: 1161: 1156: 1144: 1136: 1130: 1126: 1122: 1118: 1111: 1108: 1103: 1099: 1094: 1089: 1086:(5): 674–86. 1085: 1081: 1077: 1070: 1067: 1055: 1051: 1045: 1043: 1041: 1037: 1026: 1022: 1016: 1013: 1007: 1003: 1002:Trypanophobia 1000: 998: 995: 993: 990: 988: 985: 983: 980: 978: 975: 973: 970: 968: 965: 964: 960: 958: 956: 951: 950: 945: 941: 940:acetylcholine 937: 933: 929: 925: 920: 918: 914: 913: 908: 907: 902: 898: 894: 890: 886: 882: 878: 877:anticoagulant 874: 870: 866: 862: 857: 855: 851: 847: 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Index

Injectables
Injection

US English
UK English
Scottish English
Scots
drug
hypodermic needle
syringe
parenteral
first pass effect
subcutaneous
intramuscular
intravenous
intraperitoneal
intraosseous
intracardiac
intraarticular
intracavernous
developing
transitional countries
immunizations
vaccinations
blood transfusions
inoculation
bolus
depot injection
puncture wound
sepsis

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