378:
40:
296:
3819:
630:
448:
into the newly unoccupied NAD binding site. The arginine residue is thought to act as the general base that activates a water molecule for the hydrolysis reaction. Alternatively, molecular mechanics simulations suggest that in conditions where the arginine residue is protonated, the threonine residue
344:
nucleotide synthesis. IMPDH has also been shown to bind nucleic acids, and this function can be impaired by mutations that are located in the
Bateman domain. The Bateman domain has also been implicated in mediating IMPDH association with polyribosomes, which suggests a potential
841:
Guanine nucleotide synthesis is essential for maintaining normal cell function and growth, and is also important for the maintenance of cell proliferation and immune responses. IMPDH expression is found to be upregulated in some tumor tissues and cell lines. B and T
439:
residue attacks the 2-position of the purine ring. A hydride ion is then transferred from the C2 position to NAD and the E-XMP* intermediate is formed. NADH dissociates from the enzyme and a mobile active-site flap element moves a conserved catalytic dyad of
1225:
Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC (September 1997). "Crystal structure of
Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex".
937:
Gan L, Seyedsayamdost MR, Shuto S, Matsuda A, Petsko GA, Hedstrom L (February 2003). "The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase".
434:
reaction involving a hydride transfer to NAD which generates NADH and an enzyme-bound XMP intermediate (E-XMP*) and (2) a hydrolysis step that releases XMP from the enzyme. IMP binds to the active site and a conserved
2594:
Wang J, Yang JW, Zeevi A, Webber SA, Girnita DM, Selby R, Fu J, Shah T, Pravica V, Hutchinson IV, Burckart GJ (May 2008). "IMPDH1 gene polymorphisms and association with acute rejection in renal transplant patients".
299:
Visual representation of the active site with IMP (green) and NAD (purple) bound. Key residues (white) of the protein and the catalytic cysteine (cyan) are shown. Dashed lines represent polar contacts.
1180:
Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E, Joachimiak A, Collart FR (April 1999). "Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase".
3297:
1491:
Nimmesgern E, Black J, Futer O, Fulghum JR, Chambers SP, Brummel CL, Raybuck SA, Sintchak MD (November 1999). "Biochemical analysis of the modular enzyme inosine 5'-monophosphate dehydrogenase".
353:, IMPDH have been identified as a plasminogen-binding protein. Drosophila IMPDH has been demonstrated to act as a sequence-specific transcriptional repressor that can reduce the expression of
315:
that are inserted within the dehydrogenase sequence. Monovalent cations have been shown to activate most IMPDH enzymes and may serve to stabilize the conformation of the active-site loop.
1630:
Gedeon, Antoine; Ayoub, Nour; Brûlé, Sébastien; Raynal, Bertrand; Karimova, Gouzel; Gelin, Muriel; Mechaly, Ariel; Haouz, Ahmed; Labesse, Gilles; Munier-Lehmann, Hélène (August 2023).
2745:
2654:
810:
Both isozymes contain 514 residues, have an 84% similarity in peptide sequence, and have similar kinetic properties. Both isozymes are constitutively expressed in most tissues, but
421:
3292:
2431:
Jonsson CA, Carlsten H (January 2003). "Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses immunoglobulin and cytokine production of B cells".
1300:
Labesse, Gilles; Alexandre, Thomas; Vaupré, Laurène; Salard-Arnaud, Isabelle; Him, Joséphine Lai Kee; Raynal, Bertrand; Bron, Patrick; Munier-Lehmann, Hélène (2013-06-04).
3453:
3107:
846:
display a dependence on IMPDH for normal activation and function, and demonstrate upregulated IMPDH expression. Therefore, IMPDH has been addressed as a drug target for
205:
2341:
Aherne A, Kennan A, Kenna PF, McNally N, Lloyd DG, Alberts IL, Kiang AS, Humphries MM, Ayuso C, Engel PC, Gu JJ, Mitchell BS, Farrar GJ, Humphries P (March 2004).
3347:
2854:
1894:
Bowne SJ, Sullivan LS, Mortimer SE, Hedstrom L, Zhu J, Spellicy CJ, Gire AI, Hughbanks-Wheaton D, Birch DG, Lewis RA, Heckenlively JR, Daiger SP (January 2006).
663:
485:
311:
domain with an active site located in the loops at the C-terminal end of the barrel, and a subdomain, named the
Bateman domain, and consisting of two, repeated
224:
288:
The canonic monomeric form of IMPDH has a molecular masse of approximately 55 kDa and generally consists of 400-500 residues. IMPDHs have been described as
3141:
2730:
2647:
3382:
1526:
Buey, Rubén M.; Ledesma-Amaro, Rodrigo; Velázquez-Campoy, Adrián; Balsera, Mónica; Chagoyen, Mónica; de Pereda, José M.; Revuelta, José L. (2015-11-12).
3342:
829:
mice demonstrate a mild retinopathy in which a slow, progressive form of retinal degeneration gradually weakens visual transduction, while homozygous
318:
The
Bateman domain is not required for catalytic activity. Mutations within the Bateman domain or a complete deletion of the domain do not impair the
2820:
3227:
2740:
3170:
1265:
monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism".
2963:
3282:
2640:
272:
nucleotides from IMP. IMPDH is a regulator of the intracellular guanine nucleotide pool, and is therefore important for DNA and RNA synthesis,
2515:
Bojkova, Denisa; Klann, Kevin; Koch, Benjamin; Widera, Marek; Krause, David; Ciesek, Sandra; Cinatl, Jindrich; Münch, Christian (2020-05-14).
3100:
2577:
for "Study to
Evaluate the Safety and Efficacy of VIRAZOLE® in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19" at
2317:
1346:
PDB ID: 1NFB, Risal, D., Strickler M,D., Goldstein, B.M.,The
Conformation of NAD Bound to Human Inosine Monophosphate Dehydrogenase Type II.
3844:
3839:
3377:
3337:
3859:
3387:
3354:
1583:
Nimmesgern, E.; Black, J.; Futer, O.; Fulghum, J. R.; Chambers, S. P.; Brummel, C. L.; Raybuck, S. A.; Sintchak, M. D. (November 1999).
687:
509:
3481:
3242:
3155:
1896:"Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis"
1846:"Participation of yeast inosine 5′-monophosphate dehydrogenase in an in vitro complex with a fragment of the C-rich telomeric strand"
3538:
3237:
3137:
2859:
1089:
Sintchak MD, Nimmesgern E (May 2000). "The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors".
393:
253:
217:
3093:
2967:
2720:
2218:
Senda M, Natsumeda Y (1994). "Tissue-differential expression of two distinct genes for human IMP dehydrogenase (E.C.1.1.1.205)".
1444:"Autosomal dominant retinitis pigmentosa mutations in inosine 5'-monophosphate dehydrogenase type I disrupt nucleic acid binding"
675:
497:
3854:
3150:
3000:
2933:
2880:
2302:
Inosine-5'-monophosphate dehydrogenase: regulation of expression and role in cellular proliferation and T lymphocyte activation
885:
668:
490:
168:
3476:
3302:
2938:
2750:
2725:
1632:"Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases"
144:
3694:
3287:
449:
is also capable of activating water by accepting a proton from water while transferring its own proton to a nearby residue.
3045:
2735:
3315:
2958:
3448:
3212:
1528:"Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases"
381:
General mechanism used by the enzyme IMPDH to convert IMP to XMP. Only the purine portion of each molecule is shown.
3809:
3217:
3679:
3795:
3782:
3769:
3756:
3743:
3730:
3717:
3491:
3463:
3435:
3397:
3364:
3267:
3133:
2774:
324:
catalytic activity of some IMPDH . Other deletion examples of the
Bateman domain in IMPDH have shown an enhanced
162:
3689:
3643:
3586:
3257:
3124:
3040:
2044:
Kozhevnikova EN, van der Knaap JA, Pindyurin AV, Ozgur Z, van Ijcken WF, Moshkin YM, Verrijzer CP (July 2012).
728:
550:
423:
261:
55:
149:
2126:
Min D, Josephine HR, Li H, Lakner C, MacPherson IS, Naylor GJ, Swofford D, Hedstrom L, Yang W (August 2008).
2087:"Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs"
1995:
3591:
3415:
3222:
3060:
2804:
2763:
2632:
3307:
3120:
2779:
2258:"Increased inosine-5'-phosphate dehydrogenase gene expression in solid tumor tissues and tumor cell lines"
1189:
229:
680:
502:
406:
137:
3612:
3531:
3500:
3262:
3160:
3014:
2909:
389:
257:
3684:
1358:"Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'-phosphate dehydrogenase of
3277:
3272:
3232:
3055:
2528:
881:
878:
864:
745:
567:
346:
72:
3085:
1194:
165:
3648:
3165:
3032:
3005:
2875:
1943:
Mortimer SE, Xu D, McGrew D, Hamaguchi N, Lim HC, Bowne SJ, Daiger SP, Hedstrom L (December 2008).
1689:"A regulatory role of the Bateman domain of IMP dehydrogenase in adenylate nucleotide biosynthesis"
273:
89:
67:
17:
1740:"The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover"
3581:
2846:
2705:
2669:
2620:
2578:
3849:
3252:
3247:
2885:
2815:
2687:
2612:
2554:
2546:
2497:
2448:
2413:
2364:
2323:
2313:
2279:
2235:
2200:
2159:
2108:
2067:
2023:
2015:
1976:
1925:
1873:
1865:
1826:
1777:
1759:
1720:
1669:
1651:
1612:
1604:
1565:
1547:
1508:
1473:
1424:
1403:"Monovalent cation activation and kinetic mechanism of inosine 5'-monophosphate dehydrogenase"
1383:
1329:
1321:
1282:
1243:
1207:
1162:
1106:
1071:
1053:
1012:
994:
955:
913:
847:
156:
1994:
Mölkänen, Tomi; Tyynelä, Jaana; Helin, Jari; Kalkkinen, Nisse; Kuusela, Pentti (2002-04-24).
3627:
3622:
3596:
3524:
3420:
3207:
2890:
2604:
2536:
2487:
2479:
2440:
2403:
2395:
2354:
2305:
2269:
2257:
2227:
2190:
2149:
2139:
2098:
2057:
2007:
1966:
1956:
1915:
1907:
1857:
1816:
1808:
1767:
1751:
1710:
1700:
1659:
1643:
1596:
1555:
1539:
1500:
1463:
1455:
1414:
1373:
1313:
1274:
1235:
1199:
1152:
1144:
1098:
1061:
1043:
1002:
986:
947:
740:
733:
562:
555:
369:. In addition, metabolic stress has been shown to induce the nuclear localization of IMPDH.
336:
125:
2304:. Progress in Nucleic Acid Research and Molecular Biology. Vol. 61. pp. 181–209.
749:
571:
430:
The mechanism of IMPDH involves a sequence of two different chemical reactions: (1) a fast
3674:
3658:
3571:
3425:
3410:
2468:"Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene"
769:
591:
101:
60:
2532:
2466:
Gu JJ, Stegmann S, Gathy K, Murray R, Laliberte J, Ayscue L, Mitchell BS (August 2000).
1664:
1631:
1066:
1031:
377:
39:
3823:
3712:
3653:
3116:
3050:
2980:
2943:
2384:"Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice"
2154:
2127:
1971:
1944:
1920:
1895:
1821:
1796:
1772:
1739:
1715:
1688:
1560:
1527:
1468:
1443:
1157:
1132:
1007:
974:
295:
200:
2492:
2467:
2444:
2408:
2383:
2343:"On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa"
2309:
2195:
2178:
2103:
2086:
2011:
1861:
1378:
1357:
1278:
1102:
180:
3833:
3617:
3576:
2895:
2830:
2789:
2709:
2399:
2231:
1996:"Enhanced activation of bound plasminogen on Staphylococcus aureus by staphylokinase"
1755:
1032:"A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis"
860:
826:
175:
2624:
1795:
McLean JE, Hamaguchi N, Belenky P, Mortimer SE, Stanton M, Hedstrom L (April 2004).
3566:
2046:"Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state"
1945:"IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA"
1585:"Biochemical analysis of the modular enzyme inosine 5'-monophosphate dehydrogenase"
854:
822:
is generally upregulated in proliferating cells and neoplastic tissues. Homozygous
814:
is predominately expressed in the spleen, retina, and peripheral blood leukocytes.
277:
2573:
328:
catalytic activity in comparison with the corresponding wild-type counterpart. An
3081:
2144:
2062:
2045:
1797:"Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo"
704:
526:
280:
synthesis, as well as other process that are involved in cellular proliferation.
3790:
3725:
3561:
1845:
779:
601:
184:
3818:
1048:
3368:
3320:
2928:
2674:
2665:
2541:
2516:
1317:
918:
897:
843:
711:
533:
312:
304:
2550:
2019:
1869:
1763:
1655:
1608:
1551:
1325:
1057:
998:
3764:
3738:
3439:
2608:
2382:
Gu JJ, Tolin AK, Jain J, Huang H, Santiago L, Mitchell BS (September 2003).
1584:
1301:
875:
445:
3325:
2616:
2558:
2501:
2452:
2417:
2368:
2163:
2071:
2027:
1980:
1961:
1929:
1877:
1830:
1781:
1724:
1705:
1673:
1616:
1600:
1569:
1512:
1504:
1477:
1419:
1402:
1387:
1333:
1286:
1211:
1166:
1110:
1075:
1016:
959:
2327:
2283:
2239:
2204:
2177:
Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K (March 1990).
2112:
1428:
1247:
3077:
2359:
2342:
1911:
901:
716:
538:
441:
436:
366:
320:
289:
113:
3467:
3180:
1844:
Cornuel, Jean-François; Moraillon, Anne; Guéron, Maurice (April 2002).
1812:
1543:
1459:
792:
362:
354:
341:
330:
269:
132:
2517:"Proteomics of SARS-CoV-2-infected host cells reveals therapy targets"
1239:
1203:
1148:
990:
951:
3777:
3547:
3505:
3401:
3200:
3195:
3190:
3185:
3175:
2677:
2274:
2128:"An enzymatic atavist revealed in dual pathways for water activation"
1647:
851:
803:
797:
699:
648:
621:
521:
470:
455:
249:
245:
212:
108:
96:
84:
2483:
292:, although further data validated the existence of octameric forms.
1030:
Ayoub, Nour; Gedeon, Antoine; Munier-Lehmann, Hélène (2024-02-20).
3751:
3330:
431:
397:
376:
294:
900:
replication in cells and are being tested in clinical trials for
340:
suggests that the domain can act as a negative transregulator of
3073:
3018:
3009:
692:
514:
120:
3520:
3089:
2636:
629:
358:
264:(XMP), the first committed and rate-limiting step towards the
1261:
Prosise GL, Luecke H (February 2003). "Crystal structures of
2256:
Collart FR, Chubb CB, Mirkin BL, Huberman E (October 1992).
3298:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
3516:
1302:"MgATP regulates allostery and fiber formation in IMPDHs"
1133:"IMP dehydrogenase: structure, mechanism, and inhibition"
975:"IMP Dehydrogenase: Structure, Mechanism, and Inhibition"
818:
is generally expressed constitutively at low levels, and
349:
role for IMPDH as a translational regulatory protein. In
410:
2746:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
2300:
Zimmermann AG, Gu JJ, Laliberté J, Mitchell BS (1998).
3072:
This article incorporates text from the public domain
3807:
409:
365:
and nuclear accumulation is mostly restricted to the
303:
Most IMPDH monomers contain two domains: a catalytic
3703:
3667:
3636:
3605:
3554:
3490:
3462:
3434:
3396:
3363:
3293:
Malate dehydrogenase (oxaloacetate-decarboxylating)
3132:
3031:
2993:
2917:
2908:
2868:
2845:
2800:
2759:
2702:
2695:
2686:
775:
765:
760:
739:
727:
722:
710:
698:
686:
674:
662:
654:
644:
639:
620:
597:
587:
582:
561:
549:
544:
532:
520:
508:
496:
484:
476:
466:
461:
454:
361:. IMPDH localizes to the nucleus at the end of the
223:
211:
199:
194:
174:
155:
143:
131:
119:
107:
95:
83:
78:
66:
54:
49:
32:
3454:Vitamin-K-epoxide reductase (warfarin-insensitive)
415:
2179:"Two distinct cDNAs for human IMP dehydrogenase"
1900:Investigative Ophthalmology & Visual Science
1738:Pimkin, Maxim; Markham, George D. (April 2008).
863:is an immunosuppressant that is used to prevent
2039:
2037:
1889:
1887:
1401:Xiang B, Taylor JC, Markham GD (January 1996).
2855:Hypoxanthine-guanine phosphoribosyltransferase
2295:
2293:
2251:
2249:
1687:Pimkin M, Pimkina J, Markham GD (March 2009).
1356:Magasanik B, Moyed HS, Gehring LB (May 1957).
1126:
1124:
1122:
1120:
3532:
3101:
2648:
8:
896:IMPDH inhibitors have been shown to prevent
385:The overall reaction catalyzed by IMPDH is:
2731:Phosphoribosylglycinamide formyltransferase
833:knockout mice display embryonic lethality.
313:cystathionine beta synthetase (CBS) domains
3539:
3525:
3517:
3383:D-lactate dehydrogenase (cytochrome c-553)
3108:
3094:
3086:
2921:
2914:
2699:
2692:
2655:
2641:
2633:
757:
579:
191:
38:
2540:
2491:
2407:
2358:
2273:
2194:
2153:
2143:
2102:
2061:
1970:
1960:
1919:
1820:
1771:
1714:
1704:
1663:
1559:
1467:
1418:
1377:
1193:
1156:
1065:
1047:
1006:
408:
3228:D-malate dehydrogenase (decarboxylating)
2741:Phosphoribosylaminoimidazole carboxylase
795:of IMPDH encoded by two distinct genes,
3814:
2085:Collart FR, Huberman E (October 1988).
1442:Mortimer SE, Hedstrom L (August 2005).
929:
634:IMP dehydrogenase 2 homotetramer, Human
3283:Malate dehydrogenase (decarboxylating)
867:and acts through inhibition of IMPDH.
617:
451:
242:Inosine 5′-monophosphate dehydrogenase
33:Inosine 5'-monophosphate dehydrogenase
29:
2472:The Journal of Clinical Investigation
874:are associated with the RP10 form of
7:
3378:D-lactate dehydrogenase (cytochrome)
2964:Orotidine 5'-phosphate decarboxylase
3388:Mannitol dehydrogenase (cytochrome)
2183:The Journal of Biological Chemistry
1949:The Journal of Biological Chemistry
1693:The Journal of Biological Chemistry
1589:Protein Expression and Purification
1493:Protein Expression and Purification
1407:The Journal of Biological Chemistry
870:Mutations in the Bateman domain of
416:{\displaystyle \rightleftharpoons }
18:Inosine monophosphate dehydrogenase
3482:Quinoprotein glucose dehydrogenase
3243:Glycerol-3-phosphate dehydrogenase
3156:3-hydroxybutyryl-CoA dehydrogenase
334:deletion of the Bateman domain in
25:
3238:Glucose-6-phosphate dehydrogenase
2860:Adenine phosphoribosyltransferase
1306:Structure (London, England: 1993)
254:nicotinamide adenine dinucleotide
3817:
2968:Uridine monophosphate synthetase
2721:Ribose-phosphate diphosphokinase
2433:International Immunopharmacology
2400:10.1128/MCB.23.18.6702-6712.2003
1756:10.1111/j.1365-2958.2008.06153.x
973:Hedstrom, Lizbeth (2009-07-08).
628:
3151:3-hydroxyacyl-CoA dehydrogenase
3001:Dihydropyrimidine dehydrogenase
2934:Carbamoyl phosphate synthase II
2881:Purine nucleoside phosphorylase
3477:Malate dehydrogenase (quinone)
3303:Phosphogluconate dehydrogenase
2939:Aspartate carbamoyltransferase
2726:Amidophosphoribosyltransferase
2388:Molecular and Cellular Biology
1:
3046:Nucleoside-diphosphate kinase
2736:AIR synthetase (FGAM cyclase)
2445:10.1016/s1567-5769(02)00210-2
2310:10.1016/S0079-6603(08)60827-2
2196:10.1016/S0021-9258(19)34120-1
2104:10.1016/S0021-9258(19)37654-9
2012:10.1016/S0014-5793(02)02580-2
1862:10.1016/s0300-9084(02)01400-1
1379:10.1016/S0021-9258(18)64835-5
1279:10.1016/S0022-2836(02)01383-9
1103:10.1016/S0162-3109(00)00193-4
256:(NAD)-dependent oxidation of
3316:Hydroxysteroid dehydrogenase
3288:Malate dehydrogenase (NADP+)
2959:Dihydroorotate dehydrogenase
2232:10.1016/0024-3205(94)90150-3
2145:10.1371/journal.pbio.0060206
2063:10.1016/j.molcel.2012.04.030
1263:Tritrichomonasfoetus inosine
886:Leber's congenital amaurosis
791:Humans express two distinct
3845:Genes on human chromosome 3
3840:Genes on human chromosome 7
3449:Vitamin K epoxide reductase
3218:Carbohydrate dehydrogenases
3213:Beta-Ketoacyl ACP reductase
3876:
3860:Enzymes of known structure
3071:
1049:10.3389/fphar.2024.1329011
3695:Michaelis–Menten kinetics
3268:L-threonine dehydrogenase
2976:
2954:
2924:
2775:Adenylosuccinate synthase
2542:10.1038/s41586-020-2332-7
1318:10.1016/j.str.2013.03.011
1036:Frontiers in Pharmacology
756:
627:
578:
190:
37:
3587:Diffusion-limited enzyme
3258:Isocitrate dehydrogenase
3041:Ribonucleotide reductase
2347:Human Molecular Genetics
1131:Hedstrom L (July 2009).
262:xanthosine monophosphate
3416:L-gulonolactone oxidase
3223:Carnitine dehydrogenase
3121:alcohol oxidoreductases
3061:Dihydrofolate reductase
2609:10.1038/sj.clpt.6100347
1801:The Biochemical Journal
1448:The Biochemical Journal
424:xanthosine 5'-phosphate
3855:NADH-dependent enzymes
3308:Sorbitol dehydrogenase
2780:Adenylosuccinate lyase
2571:Clinical trial number
1962:10.1074/jbc.M806143200
1744:Molecular Microbiology
1706:10.1074/jbc.M808541200
1601:10.1006/prep.1999.1136
1505:10.1006/prep.1999.1136
1420:10.1074/jbc.271.3.1435
417:
382:
300:
284:Structure and function
3680:Eadie–Hofstee diagram
3613:Allosteric regulation
3501:Choline dehydrogenase
3263:Lactate dehydrogenase
3161:Alcohol dehydrogenase
3015:Beta-ureidopropionase
2910:Pyrimidine metabolism
2670:amino acid metabolism
2597:Clin. Pharmacol. Ther
1532:Nature Communications
837:Clinical significance
418:
380:
351:Staphylococcus aureus
298:
258:inosine monophosphate
3690:Lineweaver–Burk plot
3278:Malate dehydrogenase
3273:L-xylulose reductase
3233:DXP reductoisomerase
3056:Thymidylate synthase
3033:Deoxyribonucleotides
1912:10.1167/iovs.05-0868
1360:Aerobacter aerogenes
882:retinitis pigmentosa
865:transplant rejection
407:
390:inosine 5'-phosphate
3166:Aldo-keto reductase
3006:Dihydropyrimidinase
2876:Adenosine deaminase
2533:2020Natur.583..469B
622:IMP dehydrogenase 2
456:IMP dehydrogenase 1
276:, energy transfer,
274:signal transduction
252:that catalyzes the
3649:Enzyme superfamily
3582:Enzyme promiscuity
2847:Nucleotide salvage
2579:ClinicalTrials.gov
2360:10.1093/hmg/ddh061
1813:10.1042/BJ20031585
1544:10.1038/ncomms9923
1460:10.1042/BJ20042051
1091:Immunopharmacology
413:
383:
301:
44:Structure of IMPDH
3805:
3804:
3514:
3513:
3494:: other acceptors
3470:/similar acceptor
3253:IMP dehydrogenase
3248:HMG-CoA reductase
3069:
3068:
3027:
3026:
2989:
2988:
2904:
2903:
2886:Guanine deaminase
2841:
2840:
2816:IMP dehydrogenase
2688:Purine metabolism
2527:(7816): 469–472.
2319:978-0-12-540061-9
1240:10.1021/bi9708850
1204:10.1021/bi982858v
1149:10.1021/cr900021w
991:10.1021/cr900021w
952:10.1021/bi0271401
914:Purine metabolism
848:immunosuppressive
789:
788:
785:
784:
611:
610:
607:
606:
239:
238:
235:
234:
138:metabolic pathway
16:(Redirected from
3867:
3822:
3821:
3813:
3685:Hanes–Woolf plot
3628:Enzyme activator
3623:Enzyme inhibitor
3597:Enzyme catalysis
3541:
3534:
3527:
3518:
3421:Xanthine oxidase
3208:Aldose reductase
3110:
3103:
3096:
3087:
2922:
2915:
2891:Xanthine oxidase
2809:
2768:
2714:
2700:
2693:
2657:
2650:
2643:
2634:
2628:
2581:
2569:
2563:
2562:
2544:
2512:
2506:
2505:
2495:
2463:
2457:
2456:
2428:
2422:
2421:
2411:
2379:
2373:
2372:
2362:
2338:
2332:
2331:
2297:
2288:
2287:
2277:
2275:10.2172/10148922
2253:
2244:
2243:
2215:
2209:
2208:
2198:
2174:
2168:
2167:
2157:
2147:
2123:
2117:
2116:
2106:
2097:(30): 15769–72.
2082:
2076:
2075:
2065:
2041:
2032:
2031:
1991:
1985:
1984:
1974:
1964:
1955:(52): 36354–60.
1940:
1934:
1933:
1923:
1891:
1882:
1881:
1841:
1835:
1834:
1824:
1807:(Pt 2): 243–51.
1792:
1786:
1785:
1775:
1735:
1729:
1728:
1718:
1708:
1684:
1678:
1677:
1667:
1648:10.1002/pro.4703
1627:
1621:
1620:
1580:
1574:
1573:
1563:
1523:
1517:
1516:
1488:
1482:
1481:
1471:
1439:
1433:
1432:
1422:
1398:
1392:
1391:
1381:
1353:
1347:
1344:
1338:
1337:
1297:
1291:
1290:
1258:
1252:
1251:
1234:(35): 10666–74.
1222:
1216:
1215:
1197:
1188:(15): 4691–700.
1177:
1171:
1170:
1160:
1137:Chemical Reviews
1128:
1115:
1114:
1086:
1080:
1079:
1069:
1051:
1027:
1021:
1020:
1010:
985:(7): 2903–2928.
979:Chemical Reviews
970:
964:
963:
934:
758:
632:
618:
580:
452:
422:
420:
419:
414:
268:biosynthesis of
192:
42:
30:
27:Class of enzymes
21:
3875:
3874:
3870:
3869:
3868:
3866:
3865:
3864:
3830:
3829:
3828:
3816:
3808:
3806:
3801:
3713:Oxidoreductases
3699:
3675:Enzyme kinetics
3663:
3659:List of enzymes
3632:
3601:
3572:Catalytic triad
3550:
3545:
3515:
3510:
3486:
3458:
3430:
3426:Alcohol oxidase
3411:Glucose oxidase
3392:
3359:
3128:
3117:Oxidoreductases
3114:
3084:
3070:
3065:
3023:
2985:
2972:
2950:
2900:
2864:
2837:
2801:
2796:
2760:
2755:
2703:
2682:
2661:
2631:
2593:
2589:
2587:Further reading
2584:
2570:
2566:
2514:
2513:
2509:
2484:10.1172/JCI8669
2465:
2464:
2460:
2430:
2429:
2425:
2394:(18): 6702–12.
2381:
2380:
2376:
2340:
2339:
2335:
2320:
2299:
2298:
2291:
2262:Cancer Research
2255:
2254:
2247:
2226:(24): 1917–26.
2217:
2216:
2212:
2176:
2175:
2171:
2125:
2124:
2120:
2084:
2083:
2079:
2043:
2042:
2035:
1993:
1992:
1988:
1942:
1941:
1937:
1893:
1892:
1885:
1843:
1842:
1838:
1794:
1793:
1789:
1737:
1736:
1732:
1686:
1685:
1681:
1636:Protein Science
1629:
1628:
1624:
1582:
1581:
1577:
1525:
1524:
1520:
1490:
1489:
1485:
1441:
1440:
1436:
1400:
1399:
1395:
1355:
1354:
1350:
1345:
1341:
1299:
1298:
1294:
1260:
1259:
1255:
1224:
1223:
1219:
1195:10.1.1.488.2542
1179:
1178:
1174:
1130:
1129:
1118:
1097:(2–3): 163–84.
1088:
1087:
1083:
1029:
1028:
1024:
972:
971:
967:
936:
935:
931:
927:
910:
894:
839:
635:
616:
405:
404:
401:
375:
308:
286:
45:
28:
23:
22:
15:
12:
11:
5:
3873:
3871:
3863:
3862:
3857:
3852:
3847:
3842:
3832:
3831:
3827:
3826:
3803:
3802:
3800:
3799:
3786:
3773:
3760:
3747:
3734:
3721:
3707:
3705:
3701:
3700:
3698:
3697:
3692:
3687:
3682:
3677:
3671:
3669:
3665:
3664:
3662:
3661:
3656:
3651:
3646:
3640:
3638:
3637:Classification
3634:
3633:
3631:
3630:
3625:
3620:
3615:
3609:
3607:
3603:
3602:
3600:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3558:
3556:
3552:
3551:
3546:
3544:
3543:
3536:
3529:
3521:
3512:
3511:
3509:
3508:
3503:
3497:
3495:
3488:
3487:
3485:
3484:
3479:
3473:
3471:
3460:
3459:
3457:
3456:
3451:
3445:
3443:
3432:
3431:
3429:
3428:
3423:
3418:
3413:
3407:
3405:
3394:
3393:
3391:
3390:
3385:
3380:
3374:
3372:
3361:
3360:
3358:
3357:
3352:
3351:
3350:
3345:
3335:
3334:
3333:
3328:
3311:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3204:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3163:
3158:
3153:
3147:
3145:
3130:
3129:
3115:
3113:
3112:
3105:
3098:
3090:
3067:
3066:
3064:
3063:
3058:
3053:
3051:DCMP deaminase
3048:
3043:
3037:
3035:
3029:
3028:
3025:
3024:
3022:
3021:
3012:
3003:
2997:
2995:
2991:
2990:
2987:
2986:
2984:
2983:
2981:CTP synthetase
2977:
2974:
2973:
2971:
2970:
2961:
2955:
2952:
2951:
2949:
2948:
2947:
2946:
2944:Dihydroorotase
2941:
2936:
2925:
2919:
2912:
2906:
2905:
2902:
2901:
2899:
2898:
2893:
2888:
2883:
2878:
2872:
2870:
2866:
2865:
2863:
2862:
2857:
2851:
2849:
2843:
2842:
2839:
2838:
2836:
2835:
2834:
2833:
2823:
2818:
2812:
2810:
2798:
2797:
2795:
2794:
2793:
2792:
2782:
2777:
2771:
2769:
2757:
2756:
2754:
2753:
2748:
2743:
2738:
2733:
2728:
2723:
2717:
2715:
2697:
2690:
2684:
2683:
2681:
2680:
2672:
2662:
2660:
2659:
2652:
2645:
2637:
2630:
2629:
2590:
2588:
2585:
2583:
2582:
2564:
2507:
2478:(4): 599–606.
2458:
2423:
2374:
2333:
2318:
2289:
2268:(20): 5826–8.
2245:
2210:
2169:
2118:
2077:
2050:Molecular Cell
2033:
2006:(1–3): 72–78.
1986:
1935:
1883:
1856:(4): 279–289.
1836:
1787:
1750:(2): 342–359.
1730:
1699:(12): 7960–9.
1679:
1622:
1595:(2): 282–289.
1575:
1518:
1483:
1454:(Pt 1): 41–7.
1434:
1413:(3): 1435–40.
1393:
1348:
1339:
1312:(6): 975–985.
1292:
1253:
1217:
1172:
1143:(7): 2903–28.
1116:
1081:
1022:
965:
928:
926:
923:
922:
921:
916:
909:
906:
893:
890:
838:
835:
787:
786:
783:
782:
777:
773:
772:
767:
763:
762:
754:
753:
743:
737:
736:
731:
725:
724:
720:
719:
714:
708:
707:
702:
696:
695:
690:
684:
683:
678:
672:
671:
666:
660:
659:
656:
652:
651:
646:
642:
641:
637:
636:
633:
625:
624:
615:
612:
609:
608:
605:
604:
599:
595:
594:
589:
585:
584:
576:
575:
565:
559:
558:
553:
547:
546:
542:
541:
536:
530:
529:
524:
518:
517:
512:
506:
505:
500:
494:
493:
488:
482:
481:
478:
474:
473:
468:
464:
463:
459:
458:
428:
427:
412:
399:
374:
371:
306:
285:
282:
237:
236:
233:
232:
227:
221:
220:
215:
209:
208:
203:
197:
196:
188:
187:
178:
172:
171:
160:
153:
152:
147:
141:
140:
135:
129:
128:
123:
117:
116:
111:
105:
104:
99:
93:
92:
87:
81:
80:
76:
75:
70:
64:
63:
58:
52:
51:
47:
46:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3872:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3837:
3835:
3825:
3820:
3815:
3811:
3797:
3793:
3792:
3787:
3784:
3780:
3779:
3774:
3771:
3767:
3766:
3761:
3758:
3754:
3753:
3748:
3745:
3741:
3740:
3735:
3732:
3728:
3727:
3722:
3719:
3715:
3714:
3709:
3708:
3706:
3702:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3673:
3672:
3670:
3666:
3660:
3657:
3655:
3654:Enzyme family
3652:
3650:
3647:
3645:
3642:
3641:
3639:
3635:
3629:
3626:
3624:
3621:
3619:
3618:Cooperativity
3616:
3614:
3611:
3610:
3608:
3604:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3577:Oxyanion hole
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3559:
3557:
3553:
3549:
3542:
3537:
3535:
3530:
3528:
3523:
3522:
3519:
3507:
3504:
3502:
3499:
3498:
3496:
3493:
3489:
3483:
3480:
3478:
3475:
3474:
3472:
3469:
3465:
3461:
3455:
3452:
3450:
3447:
3446:
3444:
3441:
3437:
3433:
3427:
3424:
3422:
3419:
3417:
3414:
3412:
3409:
3408:
3406:
3403:
3399:
3395:
3389:
3386:
3384:
3381:
3379:
3376:
3375:
3373:
3370:
3366:
3362:
3356:
3353:
3349:
3346:
3344:
3341:
3340:
3339:
3336:
3332:
3329:
3327:
3324:
3323:
3322:
3319:
3317:
3313:
3312:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3168:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3148:
3146:
3143:
3139:
3135:
3131:
3126:
3122:
3118:
3111:
3106:
3104:
3099:
3097:
3092:
3091:
3088:
3083:
3079:
3075:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3038:
3036:
3034:
3030:
3020:
3016:
3013:
3011:
3007:
3004:
3002:
2999:
2998:
2996:
2992:
2982:
2979:
2978:
2975:
2969:
2965:
2962:
2960:
2957:
2956:
2953:
2945:
2942:
2940:
2937:
2935:
2932:
2931:
2930:
2927:
2926:
2923:
2920:
2916:
2913:
2911:
2907:
2897:
2896:Urate oxidase
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2873:
2871:
2867:
2861:
2858:
2856:
2853:
2852:
2850:
2848:
2844:
2832:
2831:GMP reductase
2829:
2828:
2827:
2824:
2822:
2819:
2817:
2814:
2813:
2811:
2808:
2806:
2799:
2791:
2790:AMP deaminase
2788:
2787:
2786:
2783:
2781:
2778:
2776:
2773:
2772:
2770:
2767:
2765:
2758:
2752:
2749:
2747:
2744:
2742:
2739:
2737:
2734:
2732:
2729:
2727:
2724:
2722:
2719:
2718:
2716:
2713:
2711:
2707:
2701:
2698:
2694:
2691:
2689:
2685:
2679:
2676:
2673:
2671:
2667:
2664:
2663:
2658:
2653:
2651:
2646:
2644:
2639:
2638:
2635:
2626:
2622:
2618:
2614:
2610:
2606:
2602:
2598:
2592:
2591:
2586:
2580:
2576:
2575:
2568:
2565:
2560:
2556:
2552:
2548:
2543:
2538:
2534:
2530:
2526:
2522:
2518:
2511:
2508:
2503:
2499:
2494:
2489:
2485:
2481:
2477:
2473:
2469:
2462:
2459:
2454:
2450:
2446:
2442:
2438:
2434:
2427:
2424:
2419:
2415:
2410:
2405:
2401:
2397:
2393:
2389:
2385:
2378:
2375:
2370:
2366:
2361:
2356:
2353:(6): 641–50.
2352:
2348:
2344:
2337:
2334:
2329:
2325:
2321:
2315:
2311:
2307:
2303:
2296:
2294:
2290:
2285:
2281:
2276:
2271:
2267:
2263:
2259:
2252:
2250:
2246:
2241:
2237:
2233:
2229:
2225:
2221:
2220:Life Sciences
2214:
2211:
2206:
2202:
2197:
2192:
2189:(9): 5292–5.
2188:
2184:
2180:
2173:
2170:
2165:
2161:
2156:
2151:
2146:
2141:
2137:
2133:
2129:
2122:
2119:
2114:
2110:
2105:
2100:
2096:
2092:
2091:J. Biol. Chem
2088:
2081:
2078:
2073:
2069:
2064:
2059:
2055:
2051:
2047:
2040:
2038:
2034:
2029:
2025:
2021:
2017:
2013:
2009:
2005:
2001:
1997:
1990:
1987:
1982:
1978:
1973:
1968:
1963:
1958:
1954:
1950:
1946:
1939:
1936:
1931:
1927:
1922:
1917:
1913:
1909:
1905:
1901:
1897:
1890:
1888:
1884:
1879:
1875:
1871:
1867:
1863:
1859:
1855:
1851:
1847:
1840:
1837:
1832:
1828:
1823:
1818:
1814:
1810:
1806:
1802:
1798:
1791:
1788:
1783:
1779:
1774:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1734:
1731:
1726:
1722:
1717:
1712:
1707:
1702:
1698:
1694:
1690:
1683:
1680:
1675:
1671:
1666:
1661:
1657:
1653:
1649:
1645:
1641:
1637:
1633:
1626:
1623:
1618:
1614:
1610:
1606:
1602:
1598:
1594:
1590:
1586:
1579:
1576:
1571:
1567:
1562:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1529:
1522:
1519:
1514:
1510:
1506:
1502:
1498:
1494:
1487:
1484:
1479:
1475:
1470:
1465:
1461:
1457:
1453:
1449:
1445:
1438:
1435:
1430:
1426:
1421:
1416:
1412:
1408:
1404:
1397:
1394:
1389:
1385:
1380:
1375:
1372:(1): 339–50.
1371:
1367:
1366:J. Biol. Chem
1363:
1361:
1352:
1349:
1343:
1340:
1335:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1296:
1293:
1288:
1284:
1280:
1276:
1273:(2): 517–27.
1272:
1268:
1264:
1257:
1254:
1249:
1245:
1241:
1237:
1233:
1229:
1221:
1218:
1213:
1209:
1205:
1201:
1196:
1191:
1187:
1183:
1176:
1173:
1168:
1164:
1159:
1154:
1150:
1146:
1142:
1138:
1134:
1127:
1125:
1123:
1121:
1117:
1112:
1108:
1104:
1100:
1096:
1092:
1085:
1082:
1077:
1073:
1068:
1063:
1059:
1055:
1050:
1045:
1041:
1037:
1033:
1026:
1023:
1018:
1014:
1009:
1004:
1000:
996:
992:
988:
984:
980:
976:
969:
966:
961:
957:
953:
949:
946:(4): 857–63.
945:
941:
933:
930:
924:
920:
917:
915:
912:
911:
907:
905:
903:
899:
891:
889:
887:
884:and dominant
883:
880:
877:
873:
868:
866:
862:
861:Mycophenolate
858:
856:
853:
849:
845:
836:
834:
832:
828:
825:
821:
817:
813:
808:
806:
805:
800:
799:
794:
781:
778:
774:
771:
768:
764:
759:
755:
752:
751:
747:
744:
742:
738:
735:
732:
730:
726:
721:
718:
715:
713:
709:
706:
703:
701:
697:
694:
691:
689:
685:
682:
679:
677:
673:
670:
667:
665:
661:
657:
653:
650:
647:
643:
638:
631:
626:
623:
619:
613:
603:
600:
596:
593:
590:
586:
581:
577:
574:
573:
569:
566:
564:
560:
557:
554:
552:
548:
543:
540:
537:
535:
531:
528:
525:
523:
519:
516:
513:
511:
507:
504:
501:
499:
495:
492:
489:
487:
483:
479:
475:
472:
469:
465:
460:
457:
453:
450:
447:
443:
438:
433:
425:
403:
395:
391:
388:
387:
386:
379:
372:
370:
368:
364:
360:
356:
352:
348:
343:
339:
338:
333:
332:
327:
323:
322:
316:
314:
310:
297:
293:
291:
283:
281:
279:
275:
271:
267:
263:
259:
255:
251:
248:biosynthetic
247:
244:(IMPDH) is a
243:
231:
228:
226:
222:
219:
216:
214:
210:
207:
204:
202:
198:
193:
189:
186:
182:
179:
177:
176:Gene Ontology
173:
170:
167:
164:
161:
158:
154:
151:
148:
146:
142:
139:
136:
134:
130:
127:
124:
122:
118:
115:
114:NiceZyme view
112:
110:
106:
103:
100:
98:
94:
91:
88:
86:
82:
77:
74:
71:
69:
65:
62:
59:
57:
53:
48:
41:
36:
31:
19:
3791:Translocases
3788:
3775:
3762:
3749:
3736:
3726:Transferases
3723:
3710:
3567:Binding site
3314:
2825:
2821:GMP synthase
2802:
2784:
2761:
2751:IMP synthase
2704:
2603:(5): 711–7.
2600:
2596:
2572:
2567:
2524:
2520:
2510:
2475:
2471:
2461:
2436:
2432:
2426:
2391:
2387:
2377:
2350:
2346:
2336:
2301:
2265:
2261:
2223:
2219:
2213:
2186:
2182:
2172:
2135:
2132:PLOS Biology
2131:
2121:
2094:
2090:
2080:
2056:(1): 133–9.
2053:
2049:
2003:
2000:FEBS Letters
1999:
1989:
1952:
1948:
1938:
1906:(1): 34–42.
1903:
1899:
1853:
1849:
1839:
1804:
1800:
1790:
1747:
1743:
1733:
1696:
1692:
1682:
1642:(8): e4703.
1639:
1635:
1625:
1592:
1588:
1578:
1535:
1531:
1521:
1499:(2): 282–9.
1496:
1492:
1486:
1451:
1447:
1437:
1410:
1406:
1396:
1369:
1365:
1359:
1351:
1342:
1309:
1305:
1295:
1270:
1267:J. Mol. Biol
1266:
1262:
1256:
1231:
1228:Biochemistry
1227:
1220:
1185:
1182:Biochemistry
1181:
1175:
1140:
1136:
1094:
1090:
1084:
1039:
1035:
1025:
982:
978:
968:
943:
940:Biochemistry
939:
932:
895:
871:
869:
859:
855:chemotherapy
840:
830:
823:
819:
815:
811:
809:
802:
796:
790:
748:
655:Alt. symbols
570:
477:Alt. symbols
429:
384:
350:
347:moonlighting
335:
329:
325:
319:
317:
302:
287:
278:glycoprotein
265:
241:
240:
102:BRENDA entry
3562:Active site
3442:as acceptor
2574:NCT04356677
2439:(1): 31–7.
2138:(8): e206.
1538:(1): 8923.
844:lymphocytes
770:Swiss-model
640:Identifiers
592:Swiss-model
462:Identifiers
90:IntEnz view
50:Identifiers
3834:Categories
3765:Isomerases
3739:Hydrolases
3606:Regulation
3369:cytochrome
2994:Catabolism
2869:Catabolism
2675:nucleotide
2666:Metabolism
925:References
919:Xanthosine
898:SARS-CoV-2
766:Structures
761:Search for
723:Other data
588:Structures
583:Search for
545:Other data
426:+ NADH + H
357:genes and
290:tetrameric
159:structures
126:KEGG entry
73:9028-93-7
3644:EC number
3440:disulfide
3082:IPR001093
2918:Anabolism
2696:Anabolism
2551:1476-4687
2020:0014-5793
1870:0300-9084
1850:Biochimie
1764:1365-2958
1656:0961-8368
1609:1046-5928
1552:2041-1723
1326:1878-4186
1190:CiteSeerX
1058:1663-9812
999:0009-2665
876:autosomal
734:1.1.1.205
729:EC number
705:NM_000884
664:NCBI gene
614:In humans
572:q31.3-q32
556:1.1.1.205
551:EC number
527:NM_000883
486:NCBI gene
446:threonine
411:⇌
373:Mechanism
260:(IMP) to
79:Databases
61:1.1.1.205
3850:EC 1.1.1
3668:Kinetics
3592:Cofactor
3555:Activity
3404:acceptor
3371:acceptor
3348:11β-HSD2
3343:11β-HSD1
3144:acceptor
3078:InterPro
2625:12718828
2617:17851563
2559:32408336
2502:10953035
2453:12538032
2418:12944494
2369:14981049
2164:18752347
2072:22658723
2028:12062412
1981:18974094
1930:16384941
1878:12106905
1831:14766016
1782:18312263
1725:19153081
1674:37338125
1665:10357500
1617:10545277
1570:26558346
1513:10545277
1478:15882147
1388:13428767
1334:23643948
1287:12559919
1212:10200156
1167:19480389
1111:10878288
1076:38444943
1067:10912719
1017:19480389
960:12549902
908:See also
902:COVID-19
892:Research
879:dominant
827:knockout
793:isozymes
780:InterPro
602:InterPro
442:arginine
437:cysteine
367:G2 phase
326:in vitro
321:in vitro
230:proteins
218:articles
206:articles
163:RCSB PDB
3824:Biology
3778:Ligases
3548:Enzymes
3468:quinone
2826:reverse
2785:reverse
2678:enzymes
2529:Bibcode
2328:9752721
2284:1356621
2240:7910933
2205:1969416
2155:2525682
2113:2902093
1972:2605994
1921:2581444
1822:1224093
1773:2279236
1716:2658089
1561:4660370
1469:1184561
1429:8576135
1248:9271497
1158:2737513
1008:2737513
776:Domains
712:UniProt
598:Domains
534:UniProt
363:S phase
355:histone
342:adenine
337:E. coli
331:in vivo
270:guanine
266:de novo
185:QuickGO
150:profile
133:MetaCyc
68:CAS no.
3810:Portal
3752:Lyases
3506:L2HGDH
3492:1.1.99
3402:oxygen
3326:3β-HSD
2623:
2615:
2557:
2549:
2521:Nature
2500:
2493:380246
2490:
2451:
2416:
2409:193693
2406:
2367:
2326:
2316:
2282:
2238:
2203:
2162:
2152:
2111:
2070:
2026:
2018:
1979:
1969:
1928:
1918:
1876:
1868:
1829:
1819:
1780:
1770:
1762:
1723:
1713:
1672:
1662:
1654:
1615:
1607:
1568:
1558:
1550:
1511:
1476:
1466:
1427:
1386:
1332:
1324:
1285:
1246:
1210:
1192:
1165:
1155:
1109:
1074:
1064:
1056:
1015:
1005:
997:
958:
872:IMPDH1
852:cancer
831:IMPDH2
824:IMPDH1
820:IMPDH2
816:IMPDH1
812:IMPDH1
804:IMPDH2
798:IMPDH1
746:Chr. 3
717:P12268
700:RefSeq
693:146691
649:IMPDH2
645:Symbol
568:Chr. 7
539:P20839
522:RefSeq
515:146690
471:IMPDH1
467:Symbol
309:barrel
250:enzyme
246:purine
213:PubMed
195:Search
181:AmiGO
169:PDBsum
109:ExPASy
97:BRENDA
85:IntEnz
56:EC no.
3704:Types
3464:1.1.5
3436:1.1.4
3398:1.1.3
3365:1.1.2
3331:NSDHL
3134:1.1.1
2621:S2CID
750:p21.2
741:Locus
658:IMPD2
563:Locus
432:redox
305:(β/α)
145:PRIAM
3796:list
3789:EC7
3783:list
3776:EC6
3770:list
3763:EC5
3757:list
3750:EC4
3744:list
3737:EC3
3731:list
3724:EC2
3718:list
3711:EC1
3181:1B10
3142:NADP
3127:1.1)
3076:and
3074:Pfam
3019:UPB1
3010:DPYS
2803:IMP→
2762:IMP→
2613:PMID
2555:PMID
2547:ISSN
2498:PMID
2449:PMID
2414:PMID
2365:PMID
2324:PMID
2314:ISBN
2280:PMID
2236:PMID
2201:PMID
2160:PMID
2109:PMID
2068:PMID
2024:PMID
2016:ISSN
1977:PMID
1926:PMID
1874:PMID
1866:ISSN
1827:PMID
1778:PMID
1760:ISSN
1721:PMID
1670:PMID
1652:ISSN
1613:PMID
1605:ISSN
1566:PMID
1548:ISSN
1509:PMID
1474:PMID
1425:PMID
1384:PMID
1330:PMID
1322:ISSN
1283:PMID
1244:PMID
1208:PMID
1163:PMID
1107:PMID
1072:PMID
1054:ISSN
1013:PMID
995:ISSN
956:PMID
850:and
801:and
688:OMIM
681:6053
676:HGNC
669:3615
510:OMIM
503:6052
498:HGNC
491:3614
480:RP10
444:and
225:NCBI
166:PDBe
121:KEGG
3355:17β
3338:11β
3201:7A2
3196:1C4
3191:1C3
3186:1C1
3176:1B1
3171:1A1
3138:NAD
2929:CAD
2805:GMP
2764:AMP
2710:IMP
2706:R5P
2605:doi
2537:doi
2525:583
2488:PMC
2480:doi
2476:106
2441:doi
2404:PMC
2396:doi
2355:doi
2306:doi
2270:doi
2228:doi
2191:doi
2187:265
2150:PMC
2140:doi
2099:doi
2095:263
2058:doi
2008:doi
2004:517
1967:PMC
1957:doi
1953:283
1916:PMC
1908:doi
1858:doi
1817:PMC
1809:doi
1805:379
1768:PMC
1752:doi
1711:PMC
1701:doi
1697:284
1660:PMC
1644:doi
1597:doi
1556:PMC
1540:doi
1501:doi
1464:PMC
1456:doi
1452:390
1415:doi
1411:271
1374:doi
1370:226
1314:doi
1275:doi
1271:326
1236:doi
1200:doi
1153:PMC
1145:doi
1141:109
1099:doi
1062:PMC
1044:doi
1003:PMC
987:doi
983:109
948:doi
394:NAD
359:E2F
201:PMC
157:PDB
3836::
3466::
3438::
3400::
3367::
3321:3β
3136::
3125:EC
3119::
3080::
2668::
2619:.
2611:.
2601:83
2599:.
2553:.
2545:.
2535:.
2523:.
2519:.
2496:.
2486:.
2474:.
2470:.
2447:.
2435:.
2412:.
2402:.
2392:23
2390:.
2386:.
2363:.
2351:13
2349:.
2345:.
2322:.
2312:.
2292:^
2278:.
2266:52
2264:.
2260:.
2248:^
2234:.
2224:54
2222:.
2199:.
2185:.
2181:.
2158:.
2148:.
2134:.
2130:.
2107:.
2093:.
2089:.
2066:.
2054:47
2052:.
2048:.
2036:^
2022:.
2014:.
2002:.
1998:.
1975:.
1965:.
1951:.
1947:.
1924:.
1914:.
1904:47
1902:.
1898:.
1886:^
1872:.
1864:.
1854:84
1852:.
1848:.
1825:.
1815:.
1803:.
1799:.
1776:.
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1758:.
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1308:.
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1269:.
1242:.
1232:36
1230:.
1206:.
1198:.
1186:38
1184:.
1161:.
1151:.
1139:.
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1119:^
1105:.
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1093:.
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1060:.
1052:.
1042:.
1040:15
1038:.
1034:.
1011:.
1001:.
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981:.
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954:.
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396:+
392:+
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2010::
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1959::
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1860::
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1169:.
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1113:.
1101::
1078:.
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1019:.
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962:.
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400:2
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