Knowledge (XXG)

Intercellular adhesion molecule

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Gahmberg CG, Tolvanen M, Kotovuori P (April 1997). "Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands".
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events. The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to
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structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1
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and in immune responses. In addition, ICAMs may exist in soluble forms in
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Intercellular adhesion molecule (ICAM), N-terminal domain
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This article incorporates text from the public domain
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Mammalian intercellular adhesion molecules include:
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They are important in 386:cell adhesion molecules 578:Glycoprotein IIb/IIIa 550:Macrophage-1 antigen 536:Integrin alphaXbeta2 237:Macrophage-1 antigen 415:Myelin protein zero 394:Calcium-independent 982:Biochemistry stubs 934: 933: 899: 898: 827: 826: 795: 794: 601:Calcium-dependent 595: 594: 382:Membrane proteins 184:molecular biology 180: 179: 176: 175: 171:structure summary 989: 977:Protein families 955: 948: 941: 913: 906: 615: 606: 399: 375: 368: 361: 352: 331: 330: 302: 208:immune responses 119: 28: 16: 997: 996: 992: 991: 990: 988: 987: 986: 962: 961: 960: 959: 902: 900: 895: 823: 791: 720: 692: 639: 591: 508: 388: 379: 349: 335: 334: 307:Eur. J. Biochem 304: 303: 299: 294: 31: 12: 11: 5: 995: 993: 985: 984: 979: 974: 964: 963: 958: 957: 950: 943: 935: 932: 931: 914: 897: 896: 894: 893: 888: 883: 878: 873: 867: 866: 850: 845: 835: 833: 829: 828: 825: 824: 822: 821: 816: 811: 805: 803: 797: 796: 793: 792: 790: 789: 784: 779: 774: 769: 764: 759: 754: 749: 744: 739: 734: 728: 726: 722: 721: 719: 718: 713: 708: 702: 700: 694: 693: 691: 690: 672: 649: 647: 641: 640: 638: 637: 632: 627: 621: 619: 612: 603: 597: 596: 593: 592: 590: 589: 575: 561: 547: 533: 518: 516: 510: 509: 507: 506: 505: 504: 499: 494: 489: 484: 479: 469: 468: 467: 462: 457: 452: 442: 437: 432: 418: 407: 405: 396: 390: 389: 380: 378: 377: 370: 363: 355: 333: 332: 296: 295: 293: 290: 289: 288: 283: 278: 273: 268: 254:mechanisms at 178: 177: 174: 173: 168: 162: 161: 148: 142: 141: 131: 124: 123: 115: 114: 109: 103: 102: 89: 83: 82: 77: 71: 70: 65: 58: 57: 52: 46: 45: 42: 38: 37: 33: 32: 29: 21: 20: 13: 10: 9: 6: 4: 3: 2: 994: 983: 980: 978: 975: 973: 970: 969: 967: 956: 951: 949: 944: 942: 937: 936: 930: 928: 924: 921:article is a 920: 915: 912: 908: 903: 892: 889: 887: 884: 882: 879: 877: 874: 872: 869: 868: 864: 860: 856: 855: 851: 849: 846: 844: 840: 837: 836: 834: 830: 820: 817: 815: 812: 810: 807: 806: 804: 802: 798: 788: 785: 783: 780: 778: 775: 773: 770: 768: 765: 763: 760: 758: 755: 753: 750: 748: 745: 743: 740: 738: 735: 733: 730: 729: 727: 723: 717: 714: 712: 709: 707: 704: 703: 701: 699: 698:Protocadherin 695: 688: 684: 680: 676: 673: 670: 666: 662: 658: 654: 651: 650: 648: 646: 642: 636: 633: 631: 628: 626: 623: 622: 620: 616: 613: 611: 607: 604: 602: 598: 587: 583: 579: 576: 573: 569: 565: 562: 559: 555: 551: 548: 545: 541: 537: 534: 531: 527: 523: 520: 519: 517: 515: 511: 503: 500: 498: 495: 493: 490: 488: 485: 483: 480: 478: 475: 474: 473: 470: 466: 463: 461: 458: 456: 453: 451: 448: 447: 446: 443: 441: 438: 436: 433: 430: 426: 422: 419: 416: 412: 409: 408: 406: 404: 400: 397: 395: 391: 387: 383: 376: 371: 369: 364: 362: 357: 356: 353: 348: 344: 340: 328: 324: 320: 316: 313:(2): 215–32. 312: 308: 301: 298: 291: 287: 284: 282: 279: 277: 274: 272: 269: 267: 264: 263: 262: 259: 257: 253: 249: 246: 242: 238: 234: 230: 226: 223: 220: 216: 213: 212:intracellular 209: 205: 201: 197: 193: 189: 185: 172: 169: 167: 163: 160: 156: 152: 149: 147: 143: 139: 135: 132: 129: 125: 120: 116: 113: 110: 108: 104: 101: 97: 93: 90: 88: 84: 81: 78: 76: 72: 69: 66: 63: 59: 56: 53: 51: 47: 43: 39: 34: 27: 22: 17: 972:Cell biology 927:expanding it 919:biochemistry 916: 901: 852: 420: 310: 306: 300: 260: 241:inflammation 204:inflammation 191: 187: 181: 675:Desmocollin 252:proteolysis 36:Identifiers 966:Categories 848:L-selectin 819:P-selectin 814:L-selectin 809:E-selectin 732:T-cadherin 653:Desmoglein 645:Desmosomal 292:References 258:surfaces. 215:signalling 134:structures 107:Membranome 801:Selectins 618:Classical 610:Cadherins 514:Integrins 445:L1 family 347:IPR013768 239:, during 222:integrins 219:leucocyte 80:IPR013768 854:integrin 403:IgSF CAM 343:InterPro 231:such as 151:RCSB PDB 75:InterPro 327:9151947 210:and in 55:PF03921 716:PCDH19 711:PCDH15 582:ITGA2B 472:Nectin 450:L1-CAM 440:PE-CAM 435:VCAM-1 325:  266:ICAM-1 248:plasma 194:) and 166:PDBsum 140:  130:  100:SUPFAM 68:CL0159 44:ICAM_N 41:Symbol 917:This 891:EpCAM 886:CD146 863:LFA-1 859:VLA-4 832:Other 787:CDH10 777:CDH17 772:CDH16 767:CDH15 762:CDH12 757:CDH11 706:PCDH1 586:ITGB3 568:CD49d 564:VLA-4 554:CD11b 540:CD11c 526:CD11a 522:LFA-1 502:CD155 497:CADM3 492:CADM1 487:PVRL3 482:PVRL2 477:PVRL1 460:NFASC 455:NRCAM 411:N-CAM 286:ICAM5 281:ICAM4 276:ICAM3 271:ICAM2 245:human 233:LFA-1 192:ICAMs 96:SCOPe 87:SCOP2 923:stub 881:CD44 876:CD24 843:CD44 782:CDH9 752:CDH8 747:CDH6 742:CDH5 737:CDH4 687:DSC3 683:DSC2 679:DSC1 669:DSG4 665:DSG3 661:DSG2 657:DSG1 635:CDH3 630:CDH2 625:CDH1 572:CD29 558:CD18 544:CD18 530:CD18 465:CHL1 421:ICAM 341:and 339:Pfam 323:PMID 256:cell 235:and 229:CD18 225:CD11 159:PDBj 155:PDBe 138:ECOD 128:Pfam 92:1zxq 64:clan 62:Pfam 50:Pfam 315:doi 311:245 182:In 146:PDB 112:219 968:: 861:, 841:: 685:, 681:, 667:, 663:, 659:, 427:, 384:: 345:: 321:. 309:. 206:, 186:, 157:; 153:; 136:/ 98:/ 94:/ 954:e 947:t 940:v 929:. 865:) 857:( 689:) 677:( 671:) 655:( 588:) 584:+ 580:( 574:) 570:+ 566:( 560:) 556:+ 552:( 546:) 542:+ 538:( 532:) 528:+ 524:( 431:) 429:5 425:1 423:( 417:) 413:( 374:e 367:t 360:v 329:. 317:: 227:/ 190:(

Index


Pfam
PF03921
Pfam
CL0159
InterPro
IPR013768
SCOP2
1zxq
SCOPe
SUPFAM
Membranome
219
Pfam
structures
ECOD
PDB
RCSB PDB
PDBe
PDBj
PDBsum
structure summary
molecular biology
vascular cell adhesion molecule-1
immunoglobulin superfamily
inflammation
immune responses
intracellular
signalling
leucocyte

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