1839:, treatment of cancer patients with PEG-rHuIL-10 elicits a dose titratable induction of the immune stimulatory cytokines IFNγ, IL-18, IL-7, GM-CSF and IL-4. Furthermore, treated patients exhibit fold increases of peripheral CD8+ T cells expressing markers of activation, such as programmed death 1 (PD1)+, lymphocyte activation gene 3 (LAG3)+ and increased Fas Ligand (FasL) and a decrease in serum TGFβ. These findings are consistent with the published preclinical immunoncology reports using PEG-rMuIL-10 and with previous findings treating humans with rHuIL-10. These data suggest that while IL-10 can exert immunosuppressive effects in context of bacterial product stimulated myeloid cells, rHuIL-10/PEG-rHuIL-10 treatment of humans is predominantly immunostimulatory. As of 2018 AM0010 (aka
339:
1682:
Expression of IL-10 from transfected tumor cell lines in IL-10 transgenic mice or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. More recently, PEGylated recombinant murine IL-10 (PEG-rMuIL-10) has been shown to induce IFNγ and CD8+ T cell dependent anti-tumor immunity. More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules
Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion.
316:
5047:
213:
238:
5152:
5137:
5122:
42:
5182:
5092:
345:
244:
5107:
5167:
5077:
5062:
4984:
1818:
treatment initially exhibited promising clinical data in psoriasis, but failed to achieve clinical significance in a randomized, double blind, placebo controlled Phase II trial. Further investigation of rHuIL-10's effects in humans suggests that rather than inhibiting inflammation, rHuIL-10 is capable of exerting pro-inflammatory effects.
1664:
Discovered in 1991, IL-10 was initially reported to suppress cytokine secretion, antigen presentation and CD4+ T cell activation. Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα,
1817:
Due to the data, thousands of patients with a variety of autoimmune diseases were treated with recombinant human IL-10 (rHuIL-10) in clinical trials. Contrary to expectations, rHuIL-10 treatment did not significantly impact disease in patients with Crohn's disease or rheumatoid arthritis. rHuIL-10
1681:
Over time a more nuanced picture of IL-10's function has emerged as treatment of tumor bearing mice has been shown to inhibit tumor metastasis. Additional investigation by multiple laboratories has generated data that further supports IL-10's immunostimulatory capacity in an immunoncology context.
1729:
IL-10 checks the inducible form of Cyclo-oxygenase, Cyclo-oxygenase-2 (COX-2). Lack of IL-10 has been shown to cause COX activation and resultant
Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice. Interleukin 10 knockout frail mice develop cardiac and
1752:
levels are not regulated effectively as IL-10 regulates the TNF-α-converting enzyme. As a result, TNFα levels rise and result in inflammation. TNFα itself induces demyelination of the oligodendroglial via TNF receptor 1, while chronic inflammation has been linked to demyelination of neurons.
1584:
receptors. The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. Extensive IL-10 locus remodeling is observed in monocytes upon
3952:
Fedorak RN, Gangl A, Elson CO, Rutgeerts P, Schreiber S, Wild G, et al. (December 2000). "Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The
Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group".
68:
590:
1725:
and Th1 T cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells; however, it is also stimulatory towards certain T cells (Th2) and mast cells and stimulates B cell maturation and antibody production.
4063:
van Roon J, Wijngaarden S, Lafeber FP, Damen C, van de Winkel J, Bijlsma JW (April 2003). "Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc gamma receptor expression on monocytes and responsiveness to immune complex stimulation".
3988:
Schreiber S, Fedorak RN, Nielsen OH, Wild G, Williams CN, Nikolaus S, et al. (December 2000). "Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's
Disease IL-10 Cooperative Study Group".
2726:"Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression"
1794:
A recent mouse study indicates that IL-10 regulates CD36, a key phagocytosis effector, promoting hematoma clearance after intracerebral hemorrhage. IL-10 deficiency aggravates traumatic brain injury in male but not female mice.
3767:
Ezzeddini R, Somi MH, Taghikhani M, Moaddab SY, Masnadi
Shirazi K, Shirmohammadi M, et al. (February 2021). "Association of Foxp3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients".
1830:
recombinant human IL-10 (PEG-rHuIL-10, AM0010). Consistent with preclinical immunoncology data, investigators report substantial anti-tumor efficacy. Contrary to the reported immunosuppressive effects of IL-10 generated
3235:
Berman RM, Suzuki T, Tahara H, Robbins PD, Narula SK, Lotze MT (July 1996). "Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice".
5046:
4025:
1613:
stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of
3402:
Grimbaldeston MA, Nakae S, Kalesnikoff J, Tsai M, Galli SJ (October 2007). "Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B".
3367:
Chan IH, Wu V, Bilardello M, Mar E, Oft M, Van
Vlasselaer P, et al. (December 2015). "The Potentiation of IFN-γ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells".
1862:
The receptor complex for IL-10 also requires the IL10R2 chain to initiate signalling. This ligand–receptor combination is found in birds and frogs, and is also likely to exist in bony fish.
5151:
3714:
Serrano AE, Menares-Castillo E, Garrido-Tapia M, Ribeiro CH, Hernández CJ, Mendoza-Naranjo A, et al. (March 2011). "Interleukin 10 decreases MICA expression on melanoma cell surface".
6337:
3917:
Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP, et al. (June 2006). "A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease".
5136:
4091:
Asadullah K, Döcke WD, Ebeling M, Friedrich M, Belbe G, Audring H, et al. (February 1999). "Interleukin 10 treatment of psoriasis: clinical results of a phase 2 trial".
4303:
4458:
Josephson K, McPherson DT, Walter MR (December 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1".
352:
251:
5726:
4591:
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, et al. (July 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage".
3102:
Sun H, Gutierrez P, Jackson MJ, Kundu N, Fulton AM (2000-04-01). "Essential role of nitric oxide and interferon-gamma for tumor immunotherapy with interleukin-10".
2778:"A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding"
5121:
6330:
4694:
Beebe AM, Cua DJ, de Waal
Malefyt R (2003). "The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS)".
3588:"Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment"
4988:
4128:"Clinical and immunologic assessment of patients with psoriasis in a randomized, double-blind, placebo-controlled trial using recombinant human interleukin 10"
5181:
5091:
2874:
Opp MR, Smith EM, Hughes TK (July 1995). "Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep".
3860:
Gu Y, Dong Y, Wan J, Ren H, Koehler RC, Wang J (September 2022). "Interleukin-10 deficiency aggravates traumatic brain injury in male but not female mice".
4839:
Asadullah K, Sabat R, Friedrich M, Volk HD, Sterry W (June 2004). "Interleukin-10: an important immunoregulatory cytokine with major impact on psoriasis".
1133:
4271:
1114:
174:
6323:
5802:
1810:
react favorably towards treatment with recombinant interleukin-10-producing bacteria, demonstrating the importance of IL-10 for counteracting the
3494:
Ostrowski K, Schjerling P, Pedersen BK (December 2000). "Physical activity and plasma interleukin-6 in humans--effect of intensity of exercise".
7535:
6802:
6197:
1856:
1419:
7539:
7525:
7485:
5026:
1938:
1602:
1423:
1920:
1806:
studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. and, indeed, patients with
7600:
7554:
3671:
Nakahara J, Maeda M, Aiso S, Suzuki N (February 2012). "Current concepts in multiple sclerosis: autoimmunity versus oligodendrogliopathy".
1959:
Eskdale J, Kube D, Tesch H, Gallagher G (1997). "Mapping of the human IL10 gene and further characterization of the 5' flanking sequence".
3063:"Interleukin-10 gene transfer activates interferon-gamma and the interferon-gamma-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary tumors"
2920:
Aste-Amezaga M, Ma X, Sartori A, Trinchieri G (June 1998). "Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10".
5222:
3079:
3062:
1333:
338:
7459:
1340:
6407:
6088:
4503:"Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization"
315:
3903:
1826:
Further to these data, a Phase I immunoncology clinical trial is currently being conducted to assess the therapeutic capacity of
3284:"IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs"
2846:
2829:
2056:"Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma"
5618:
1907:
1886:
5055:: INTERLEUKIN-10 CRYSTAL STRUCTURE REVEALS THE FUNCTIONAL DIMER WITH AN UNEXPECTED TOPOLOGICAL SIMILARITY TO INTERFERON GAMMA
2674:"Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes"
3629:"Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism"
1903:
237:
212:
65:
7420:
7399:
5395:
5106:
4905:"Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage"
4216:"Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma"
5166:
2144:
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB (2004). "Interleukin-10 and related cytokines and receptors".
1882:
4870:"IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly"
154:
4548:"Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco"
2181:"Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection"
6231:
5781:
5556:
5076:
1852:
1749:
1714:
351:
250:
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6066:
5776:
2637:
Moore KW, de Waal
Malefyt R, Coffman RL, O'Garra A (2001-01-01). "Interleukin-10 and the interleukin-10 receptor".
1658:
1577:
1427:
3813:"Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36"
2531:"Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family"
2334:"IL-35 is a novel responsive anti-inflammatory cytokine--a new system of categorizing anti-inflammatory cytokines"
6185:
5870:
5019:
4026:"Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group"
1606:
1426:
proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces
344:
243:
1605:
and NF-κB signalling and transcriptional activation via promoter binding of the transcription factors NF-κB and
6220:
5647:
5623:
4998:
4752:
Roncarolo MG, Battaglia M, Gregori S (June 2003). "The role of interleukin 10 in the control of autoimmunity".
4272:"A first-in-human dose escalation study of PEGylated recombinant human IL-10 (AM0010) in advanced solid tumors"
1626:
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162:
4628:
Moore KW, de Waal
Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor".
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7378:
7338:
7317:
7261:
7229:
7188:
7146:
7100:
7019:
6993:
6937:
6896:
6870:
6844:
6498:
5215:
4283:
1569:
1431:
1159:
6953:
5061:
6813:
6793:
6772:
6691:
6630:
6574:
6528:
6452:
6357:
5548:
1581:
2490:"Posttranscriptional regulation of IL-10 gene expression through sequences in the 3'-untranslated region"
7605:
6463:
4868:
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4810:
Llorente L, Richaud-Patin Y (June 2003). "The role of interleukin-10 in systemic lupus erythematosus".
4305:
Early Data Supports Phase 3 Trial of Pegilodecakin as Possible Treatment for Advanced Pancreatic Cancer
3147:"A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells"
1737:, as exercise provokes an increase in circulating levels of IL-1ra, IL-10, and sTNF-R, suggesting that
7575:
5160:: Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain
2724:
de Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, et al. (October 1991).
7358:
6346:
6074:
5012:
4467:
4330:
2591:
2345:
1670:
1522:
226:
6488:
141:
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6907:
6702:
6478:
6372:
5916:
4723:
Mocellin S, Panelli MC, Wang E, Nagorsen D, Marincola FM (January 2003). "The dual role of IL-10".
1498:
1490:
7219:
7214:
2283:) Signals via G-alpha-s and Induces IL-6 and IL-10 Cytokine Secretion in Human Primary Leukocytes"
1783:
through influencing Tregs function and the secretion of immunomodulatory cytokines such as IL-10,
7199:
7111:
7090:
6539:
6473:
6432:
6376:
6349:
6083:
6040:
5955:
5798:
5662:
5208:
4682:
4616:
3885:
3793:
3749:
3696:
3519:
3427:
3261:
3176:
3127:
2965:"Cellular mechanisms that cause suppressed gamma interferon secretion in endotoxin-tolerant mice"
2945:
2899:
2807:
2429:
1984:
1745:
1666:
1586:
1486:
186:
7080:
6948:
6855:
6834:
6585:
6554:
6549:
6493:
6412:
3447:"Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age"
2963:
Varma TK, Toliver-Kinsky TE, Lin CY, Koutrouvelis AP, Nichols JE, Sherwood ER (September 2001).
1807:
1316:
1295:
1269:
1248:
7126:
6559:
6387:
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6732:
6717:
6681:
6651:
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5432:
4963:
4946:
Copeland KF (December 2005). "Modulation of HIV-1 transcription by cytokines and chemokines".
4934:
4891:
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4827:
4798:
4769:
4740:
4711:
4674:
4645:
4608:
4579:
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4483:
4440:
4399:
4358:
4245:
4193:
4149:
4108:
4073:
4045:
4006:
3970:
3934:
3877:
3842:
3785:
3741:
3688:
3650:
3609:
3568:
3511:
3476:
3419:
3384:
3349:
3305:
3253:
3217:
3196:"Interleukin-10 promotes the maintenance of antitumor CD8(+) T-cell effector function in situ"
3168:
3119:
3084:
3043:
2994:
2937:
2891:
2851:
2799:
2755:
2703:
2654:
2619:
2560:
2511:
2470:
2421:
2373:
2314:
2259:
2210:
2161:
2126:
2077:
2036:
1976:
1738:
1695:
1557:
1478:
134:
58:
4546:
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2447:
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2157:
7570:
6259:
6180:
6048:
5737:
5571:
4955:
4924:
4916:
4881:
4848:
4819:
4790:
4761:
4732:
4703:
4666:
4637:
4600:
4569:
4559:
4514:
4475:
4430:
4389:
4348:
4338:
4235:
4227:
4183:
4139:
4100:
4037:
3998:
3962:
3926:
3869:
3832:
3824:
3777:
3731:
3723:
3680:
3640:
3599:
3558:
3550:
3503:
3466:
3458:
3411:
3376:
3339:
3295:
3245:
3207:
3158:
3111:
3074:
3033:
3025:
2984:
2976:
2929:
2883:
2841:
2789:
2745:
2737:
2693:
2685:
2646:
2609:
2599:
2550:
2542:
2501:
2460:
2411:
2403:
2363:
2353:
2304:
2294:
2249:
2241:
2200:
2192:
2153:
2116:
2108:
2067:
2026:
2018:
1968:
1702:
1653:. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block
431:
362:
306:
261:
41:
7046:
7042:
7038:
4270:
Infante JR, Naing A, Papadopoulos KP, Autio KA, Ott PA, Wong DJ, et al. (2015-05-20).
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3445:
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2830:"IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway"
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5145:: Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain
4471:
4334:
2595:
2449:"Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10"
2349:
7560:
7550:
7545:
7531:
7517:
7507:
7502:
7449:
7431:
7410:
7389:
7368:
7354:
7328:
7272:
7240:
7204:
7167:
7162:
7157:
7121:
7116:
7030:
7009:
6963:
6912:
6881:
6595:
6564:
6300:
6150:
6146:
6128:
6123:
5926:
5921:
5911:
5906:
5901:
5896:
5891:
5856:
5851:
5846:
5825:
5820:
5815:
5810:
5765:
5760:
5755:
5750:
5698:
5683:
5674:
5231:
4929:
4904:
4574:
4547:
4419:"Characterization of recombinant extracellular domain of human interleukin-10 receptor"
4378:"Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site"
4240:
4215:
3837:
3812:
3563:
3538:
3471:
3446:
3038:
3013:
2750:
2725:
2698:
2673:
2614:
2579:
2555:
2530:
2368:
2333:
2309:
2278:
2254:
2229:
2205:
2180:
2121:
2096:
2031:
2006:
1780:
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4765:
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1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
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873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
672:
667:
651:
646:
641:
636:
631:
589:
7594:
7302:
6958:
6824:
6783:
6707:
6641:
6590:
6544:
6483:
6368:
6290:
6285:
6280:
6226:
6175:
5841:
5745:
5721:
5716:
5693:
5688:
5679:
5670:
5452:
4886:
4869:
4641:
4519:
4502:
4353:
4318:
4041:
3889:
3797:
3753:
3604:
3587:
3554:
3115:
2989:
2964:
2887:
2650:
2054:
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2022:
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618:
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4620:
4604:
4417:
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3873:
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1988:
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5771:
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3012:
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2903:
2433:
2230:"The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion"
1811:
1646:
1641:, effects in immunoregulation and inflammation. It downregulates the expression of
1408:
424:
203:
6315:
3326:
Mumm JB, Emmerich J, Zhang X, Chan I, Wu L, Mauze S, et al. (December 2011).
3300:
3283:
166:
4144:
4127:
3014:"Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism"
2933:
2358:
2112:
190:
7307:
7287:
7250:
7085:
7075:
6927:
6922:
6757:
6727:
6666:
6508:
6468:
6427:
6422:
6192:
6138:
5879:
5638:
5561:
4188:
4171:
3462:
3163:
3146:
2672:
de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE (November 1991).
1943:
National Center for Biotechnology Information, U.S. National Library of Medicine
1925:
National Center for Biotechnology Information, U.S. National Library of Medicine
1722:
1694:, counteracting the inflammatory effect that these cells have at the site of an
1638:
1609:. IL-10 may autoregulate its expression via a negative feed-back loop involving
1590:
4959:
4323:
Proceedings of the National Academy of Sciences of the United States of America
4104:
3781:
3249:
2584:
Proceedings of the National Academy of Sciences of the United States of America
2506:
2489:
1701:
IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as
507:
7292:
7282:
7177:
7070:
7065:
6886:
6747:
6737:
6671:
6605:
6518:
6513:
6442:
6245:
5938:
5628:
5588:
4920:
4479:
3930:
3828:
3684:
3344:
3327:
2245:
1771:) as a transcription factor is an essential molecular marker of regulatory T (
1650:
1534:
1451:
323:
220:
170:
17:
4852:
4657:
Girndt M (2003). "Humoral immune responses in uremia and the role of IL-10".
4501:
Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (May 1999).
4435:
4418:
4343:
3539:"Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans"
3212:
3195:
2580:"Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a"
2299:
6762:
6752:
6742:
6615:
5250:
5200:
4002:
3966:
2604:
1827:
1691:
1610:
1546:
1482:
1078:
567:
445:
390:
377:
289:
276:
178:
5130:: Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain
4967:
4938:
4895:
4860:
4831:
4802:
4773:
4744:
4715:
4678:
4649:
4612:
4583:
4564:
4528:
4487:
4403:
4249:
4197:
4153:
4112:
4077:
4010:
3974:
3938:
3881:
3846:
3789:
3745:
3692:
3654:
3613:
3515:
3480:
3423:
3388:
3353:
3309:
3221:
3123:
3080:
10.1002/(sici)1097-0215(19990209)80:4<624::aid-ijc23>3.0.co;2-9
2998:
2855:
2803:
2689:
2658:
2623:
2564:
2515:
2474:
2425:
2377:
2318:
2263:
2214:
2165:
2130:
2040:
1009:
positive regulation of vascular associated smooth muscle cell proliferation
1004:
negative regulation of vascular associated smooth muscle cell proliferation
4983:
4444:
4362:
4049:
3645:
3628:
3572:
3507:
3380:
3257:
3172:
3088:
3047:
3029:
2941:
2895:
2794:
2777:
2759:
2741:
2707:
2546:
2465:
2448:
2081:
1980:
1972:
1380:
1375:
689:
negative regulation of chronic inflammatory response to antigenic stimulus
6402:
6240:
5235:
4231:
3727:
1788:
1757:
1748:
when compared to healthy individuals. Due to a decrease in IL-10 levels,
1654:
1622:
1530:
1411:
1364:
1223:
1204:
3811:
Li Q, Lan X, Han X, Durham F, Wan J, Weiland A, et al. (May 2021).
3736:
3537:
Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK (February 1999).
1457:
IL-10 is classified as a class-2 cytokine, a set of cytokines including
7521:
7004:
5190:: CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-10 AT 1.6 ANGSTROMS RESOLUTION
5100:: ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT
2847:
10.1002/1521-4141(200006)30:6<1683::AID-IMMU1683>3.0.CO;2-A
2529:
Schulte LN, Eulalio A, Mollenkopf HJ, Reinhardt R, Vogel J (May 2011).
2332:
Li X, Mai J, Virtue A, Yin Y, Gong R, Sha X, et al. (March 2012).
1744:
Lower levels of IL-10 have been observed in individuals diagnosed with
1734:
1190:
1145:
4670:
2416:
1779:
polymorphism (rs3761548) might be involved in cancer progression like
774:
negative regulation of cytokine production involved in immune response
111:
107:
103:
99:
95:
91:
87:
7136:
6118:
6015:
6010:
6005:
6000:
5995:
5990:
5708:
5513:
5497:
5492:
5487:
5482:
5477:
5467:
5462:
1718:
1565:
1561:
1348:
1100:
2407:
2228:
Ağaç D, Estrada LD, Maples R, Hooper LV, Farrar JD (November 2018).
2196:
4317:
Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993).
3415:
1434:
of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by
1039:
positive regulation of pri-miRNA transcription by RNA polymerase II
7443:
7439:
7435:
7054:
7050:
7034:
6154:
6113:
6108:
6103:
6098:
6093:
6030:
6020:
5985:
5980:
5975:
5970:
5965:
5960:
5613:
5608:
5598:
5583:
5578:
5457:
5447:
5442:
5437:
5427:
5422:
5416:
5400:
5390:
5385:
5380:
5375:
5370:
5365:
5360:
5355:
5349:
5344:
5339:
5334:
5329:
5324:
5319:
5314:
4903:
Chang CF, Wan J, Li Q, Renfroe SC, Heller NM, Wang J (July 2017).
4319:"A receptor for interleukin 10 is related to interferon receptors"
1784:
1776:
1768:
1761:
1573:
1572:
triggering in these cells. IL-10 upregulation is also mediated by
1506:
1502:
1494:
2277:
Saroz Y, Kho DT, Glass M, Graham ES, Grimsey NL (December 2019).
1418:
gene. IL-10 signals through a receptor complex consisting of two
1063:
1059:
6078:
6025:
5593:
5534:
5529:
5309:
5304:
5299:
5294:
5288:
5282:
5276:
5270:
5265:
2488:
Powell MJ, Thompson SA, Tone Y, Waldmann H, Tone M (July 2000).
1772:
1598:
1594:
1553:
1526:
764:
positive regulation of DNA-binding transcription factor activity
724:
negative regulation of chemokine (C-C motif) ligand 5 production
158:
6319:
5204:
5008:
2776:
Akdis CA, Joss A, Akdis M, Faith A, Blaser K (September 2000).
2097:"Interferon-λ: Immune Functions at Barrier Surfaces and Beyond"
598:
7511:
5004:
1550:
1034:
positive regulation of receptor signaling pathway via JAK-STAT
899:
negative regulation of membrane protein ectodomain proteolysis
4460:
Acta Crystallographica. Section D, Biological Crystallography
1044:
negative regulation of hydrogen peroxide-induced neuron death
4172:"Proinflammatory effects of IL-10 during human endotoxemia"
2828:
Joss A, Akdis M, Faith A, Blaser K, Akdis CA (June 2000).
1690:
A study in mice has shown that IL-10 is also produced by
929:
positive regulation of transcription by RNA polymerase II
699:
negative regulation of endothelial cell apoptotic process
3328:"IL-10 elicits IFNγ-dependent tumor immune surveillance"
3194:
Fujii S, Shimizu K, Shimizu T, Lotze MT (October 2001).
854:
negative regulation of nitric oxide biosynthetic process
824:
negative regulation of myeloid dendritic cell activation
794:
negative regulation of MHC class II biosynthetic process
694:
positive regulation of MHC class II biosynthetic process
414:
3061:
Sun H, Jackson MJ, Kundu N, Fulton AM (February 1999).
1741:
fosters an environment of anti-inflammatory cytokines.
894:
negative regulation of tumor necrosis factor production
1760:
cell lines, IL-10 modulates the surface expression of
859:
branching involved in labyrinthine layer morphogenesis
744:
cellular response to hepatocyte growth factor stimulus
4024:
van Deventer SJ, Elson CO, Fedorak RN (August 1997).
2007:"Interleukin-10: new perspectives on an old cytokine"
979:
positive regulation of heterotypic cell-cell adhesion
974:
negative regulation of heterotypic cell-cell adhesion
964:
positive regulation of endothelial cell proliferation
579:
2915:
2913:
969:
negative regulation of cell population proliferation
7495:
7475:
7468:
7419:
7398:
7377:
7337:
7316:
7260:
7228:
7187:
7145:
7099:
7018:
6992:
6936:
6895:
6869:
6843:
6812:
6792:
6771:
6690:
6629:
6573:
6527:
6451:
6356:
6210:
6168:
6137:
6065:
6039:
5946:
5937:
5878:
5869:
5834:
5797:
5735:
5707:
5661:
5646:
5637:
5547:
5522:
5506:
5409:
5258:
5249:
5242:
1657:activity, and is involved in the regulation of the
1309:
1288:
1262:
1241:
1019:
positive regulation of transcription, DNA-templated
1899:
1897:
1895:
1878:
1876:
1874:
709:negative regulation of interferon-gamma production
944:negative regulation of sensory perception of pain
361:
260:
145:, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10
4376:Josephson K, Logsdon NJ, Walter MR (July 2001).
3666:
3664:
3277:
3275:
934:negative regulation of interleukin-12 production
789:negative regulation of interleukin-18 production
4265:
4263:
4261:
4259:
2719:
2717:
2389:
2387:
869:regulation of complement-dependent cytotoxicity
834:negative regulation of interleukin-8 production
754:negative regulation of interleukin-6 production
739:negative regulation of interleukin-1 production
719:positive regulation of B cell apoptotic process
4841:Current Drug Targets. Inflammation and Allergy
1904:GRCm38: Ensembl release 89: ENSMUSG00000016529
1414:. In humans, interleukin 10 is encoded by the
6331:
5216:
5020:
3369:Journal of Interferon & Cytokine Research
2771:
2769:
2000:
1998:
1954:
1952:
1049:positive regulation of sprouting angiogenesis
8:
4209:
4207:
4165:
4163:
3673:Clinical Reviews in Allergy & Immunology
3321:
3319:
2823:
2821:
2287:ACS Pharmacology & Translational Science
2095:Lazear HM, Nice TJ, Diamond MS (July 2015).
949:positive regulation of macrophage activation
919:negative regulation of inflammatory response
2869:
2867:
2865:
1883:GRCh38: Ensembl release 89: ENSG00000136634
914:negative regulation of B cell proliferation
849:negative regulation of T cell proliferation
7472:
6338:
6324:
6316:
5943:
5875:
5658:
5643:
5255:
5246:
5223:
5209:
5201:
5027:
5013:
5005:
1649:antigens, and co-stimulatory molecules on
1568:. IL-10 can be produced by monocytes upon
1401:human cytokine synthesis inhibitory factor
1074:
924:negative regulation of cytokine production
614:
402:
301:
198:
76:
4997:at the U.S. National Library of Medicine
4928:
4885:
4573:
4563:
4518:
4434:
4393:
4352:
4342:
4239:
4187:
4143:
3836:
3735:
3644:
3603:
3562:
3470:
3343:
3299:
3211:
3162:
3078:
3037:
2988:
2845:
2793:
2749:
2697:
2613:
2603:
2554:
2505:
2464:
2415:
2367:
2357:
2308:
2298:
2253:
2204:
2120:
2071:
2030:
1730:vascular dysfunction with increased age.
1014:interleukin-12-mediated signaling pathway
989:negative regulation of mitotic cell cycle
7503:Interleukin 14 (taxilin alpha, HMW-BCGF)
3919:Clinical Gastroenterology and Hepatology
2158:10.1146/annurev.immunol.22.012703.104622
769:negative regulation of apoptotic process
734:negative regulation of cytokine activity
714:regulation of sensory perception of pain
5042:
1870:
1560:, and in a certain subset of activated
909:cellular response to lipopolysaccharide
749:cellular response to estradiol stimulus
6801:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
3496:European Journal of Applied Physiology
1857:Interleukin 10 receptor, alpha subunit
1665:IL-1β, IL-12, and IFNγ secretion from
31:
4989:Interferons or interleukin-10 (IL-10)
1767:In addition, Forkhead box protein 3 (
784:cytoplasmic sequestering of NF-kappaB
366:
327:
322:
265:
224:
219:
7:
4696:Cytokine & Growth Factor Reviews
3018:The Journal of Experimental Medicine
2730:The Journal of Experimental Medicine
2678:The Journal of Experimental Medicine
2005:Mosser DM, Zhang X (December 2008).
1485:, -beta, -epsilon, -kappa, -omega),
5115:: STRUCTURE OF VIRAL INTERLEUKIN-10
4948:Mini Reviews in Medicinal Chemistry
4423:The Journal of Biological Chemistry
1637:IL-10 is a cytokine with multiple,
1593:pathways. IL-10 induction involves
1517:In humans, IL-10 is encoded by the
1029:cytokine-mediated signaling pathway
5175:: Crystal structure of human IL-10
3904:"Entrez Gene: IL10 interleukin 10"
3592:Scandinavian Journal of Immunology
1306:
1285:
1259:
1238:
1214:
1195:
1169:
1150:
1124:
1105:
999:regulation of response to wounding
994:endothelial cell apoptotic process
959:regulation of synapse organization
584:
502:
440:
419:
25:
1843:) is in phase 3 clinical trials.
984:positive regulation of cell cycle
5180:
5165:
5150:
5135:
5120:
5105:
5090:
5075:
5060:
5045:
4982:
4887:10.1111/j.1523-1755.2005.00200.x
4642:10.1146/annurev.immunol.19.1.683
4520:10.1046/j.1432-1327.1999.00363.x
4507:European Journal of Biochemistry
4282:(15_suppl): 3017. Archived from
4042:10.1053/gast.1997.v113.pm9247454
3605:10.1046/j.1365-3083.1999.00546.x
3555:10.1111/j.1469-7793.1999.287ad.x
3116:10.1097/00002371-200003000-00005
2651:10.1146/annurev.immunol.19.1.683
2023:10.1111/j.1600-065X.2008.00706.x
1024:negative regulation of autophagy
588:
526:lumbar subsegment of spinal cord
350:
343:
337:
314:
249:
242:
236:
211:
40:
7329:Interleukin 27 (interleukin 30)
5085:: HUMAN IL-10 / IL-10R1 COMPLEX
4605:10.1016/j.pneurobio.2019.03.003
3874:10.1016/j.expneurol.2022.114125
3067:International Journal of Cancer
2981:10.1128/iai.69.9.5249-5263.2001
1529:, and is primarily produced by
889:regulation of isotype switching
647:interleukin-10 receptor binding
3633:European Journal of Immunology
2834:European Journal of Immunology
2453:European Journal of Immunology
1450:; each of its subunits is 178-
839:response to lipopolysaccharide
599:More reference expression data
568:More reference expression data
1:
4824:10.1016/S0896-8411(03)00043-X
4795:10.1016/S0896-8411(03)00044-1
4766:10.1016/S0896-8411(03)00047-7
4737:10.1016/S1471-4906(02)00009-1
4708:10.1016/S1359-6101(02)00025-4
4395:10.1016/S1074-7613(01)00169-8
3817:Brain, Behavior, and Immunity
3301:10.1158/0008-5472.CAN-12-0721
2234:Brain, Behavior, and Immunity
2073:10.1016/S0969-2126(01)00193-9
939:defense response to protozoan
879:regulation of gene expression
864:defense response to bacterium
804:response to organic substance
652:protein dimerization activity
335:
234:
4145:10.1001/archderm.138.10.1341
2934:10.4049/jimmunol.160.12.5936
2888:10.1016/0165-5728(95)00066-b
2359:10.1371/journal.pone.0033628
2113:10.1016/j.immuni.2015.07.001
7601:Genes on human chromosome 1
6679:Antisense oligonucleotides:
4630:Annual Review of Immunology
4189:10.4049/jimmunol.165.5.2783
4066:The Journal of Rheumatology
3716:Immunology and Cell Biology
3463:10.1016/j.exger.2012.11.001
3164:10.4049/jimmunol.162.3.1723
2639:Annual Review of Immunology
2279:"Cannabinoid Receptor 2 (CB
2146:Annual Review of Immunology
1812:hyperactive immune response
809:response to carbon monoxide
7622:
4960:10.2174/138955705774933383
4105:10.1001/archderm.135.2.187
3782:10.1016/j.cyto.2020.155351
3250:10.4049/jimmunol.157.1.231
2876:Journal of Neuroimmunology
2507:10.4049/jimmunol.165.1.292
2396:Nature Reviews. Immunology
1659:JAK-STAT signaling pathway
1521:gene, which is located on
1442:Gene and protein structure
779:response to glucocorticoid
27:Anti-inflammatory cytokine
6186:Colony-stimulating factor
5040:
4921:10.1016/j.nbd.2017.03.016
4480:10.1107/S0907444901016249
3931:10.1016/j.cgh.2006.03.028
3829:10.1016/j.bbi.2021.02.001
3685:10.1007/s12016-011-8287-6
3543:The Journal of Physiology
3345:10.1016/j.ccr.2011.11.003
2246:10.1016/j.bbi.2018.09.004
1939:"Mouse PubMed Reference:"
1921:"Human PubMed Reference:"
1533:and, to a lesser extent,
1379:
1374:
1370:
1363:
1347:
1341:Chr 1: 130.95 – 130.95 Mb
1334:Chr 1: 206.77 – 206.77 Mb
1328:
1313:
1292:
1281:
1266:
1245:
1234:
1221:
1217:
1202:
1198:
1189:
1176:
1172:
1157:
1153:
1144:
1131:
1127:
1112:
1108:
1099:
1084:
1077:
1073:
1057:
617:
613:
596:
587:
578:
565:
514:
505:
452:
443:
413:
405:
401:
384:
371:
334:
313:
304:
300:
283:
270:
233:
210:
201:
197:
152:
149:
139:
132:
127:
84:
79:
62:
57:
52:
48:
39:
34:
6221:proinflammatory cytokine
4999:Medical Subject Headings
4853:10.2174/1568010043343886
4593:Progress in Neurobiology
4436:10.1074/jbc.270.21.12906
4344:10.1073/pnas.90.23.11267
3451:Experimental Gerontology
3213:10.1182/blood.v98.7.2143
3104:Journal of Immunotherapy
2300:10.1021/acsptsci.9b00049
1851:IL-10 has been shown to
1513:Expression and synthesis
7369:Interleukin-29 (IFN-λ1)
6514:Daclizumab (dacliximab)
6499:Tucotuzumab celmoleukin
4909:Neurobiology of Disease
4812:Journal of Autoimmunity
4783:Journal of Autoimmunity
4754:Journal of Autoimmunity
4132:Archives of Dermatology
4093:Archives of Dermatology
4003:10.1053/gast.2000.20196
3967:10.1053/gast.2000.20229
2605:10.1073/pnas.0808743106
1733:IL-10 is linked to the
1493:(IFN-lambda, including
1446:The IL-10 protein is a
1438:and Tyk2 respectively.
7350:Interferon λ4 (IFN-λ4)
6443:Rilonacept (IL-1 Trap)
5352:/PARC/DCCK1/AMAC1/MIP4
4565:10.1186/1472-6750-9-22
4276:ASCO Meeting Abstracts
3862:Experimental Neurology
2969:Infection and Immunity
2690:10.1084/jem.174.5.1209
1799:Clinical use or trials
1721:made by cells such as
884:B cell differentiation
819:type 2 immune response
729:response to inactivity
637:growth factor activity
542:lumbar spinal ganglion
7273:Interleukin 23 (SGRF)
6954:Cintredekin besudotox
6882:Interleukin 11 (AGIF)
6861:Interleukin 10 (CSIF)
4176:Journal of Immunology
3646:10.1002/eji.200737821
3508:10.1007/s004210000312
3381:10.1089/jir.2014.0221
3238:Journal of Immunology
3151:Journal of Immunology
3030:10.1084/jem.184.2.579
2922:Journal of Immunology
2795:10.1096/fj.99-0874fje
2742:10.1084/jem.174.4.915
2547:10.1038/emboj.2011.94
2494:Journal of Immunology
2466:10.1002/eji.200526192
2011:Immunological Reviews
1973:10.1007/s002510050250
1671:myeloid lineage cells
904:inflammatory response
550:tracheobronchial tree
530:stroma of bone marrow
6347:Interleukin receptor
5070:: CYTOKINE SYNTHESIS
4991:at Wikimedia Commons
4874:Kidney International
4725:Trends in Immunology
4466:(Pt 12): 1908–1911.
4232:10.1136/gut.50.2.191
3728:10.1038/icb.2010.100
844:B cell proliferation
814:leukocyte chemotaxis
799:response to activity
668:extracellular region
484:right adrenal cortex
368:1 E4|1 56.89 cM
329:Chromosome 1 (mouse)
227:Chromosome 1 (human)
80:List of PDB id codes
53:Available structures
6479:Denileukin diftitox
5917:Interferon type III
4472:2001AcCrD..57.1908J
4429:(21): 12906–12911.
4335:1993PNAS...9011267H
4329:(23): 11267–11271.
2596:2009PNAS..106.5761S
2350:2012PLoSO...733628L
1814:in the human body.
1525:and comprises five
829:response to insulin
673:extracellular space
488:left adrenal cortex
7051:E (interleukin 25)
4659:Blood Purification
1746:multiple sclerosis
1667:Toll-Like Receptor
1582:type 2 cannabinoid
1558:regulatory T cells
1479:interferons type-I
1179:ENSMUSG00000016529
954:liver regeneration
682:Biological process
661:Cellular component
625:Molecular function
7588:
7587:
7584:
7583:
7553:(signals through
7534:(signals through
7520:(signals through
7510:(signals through
7134:Binding proteins:
6464:Adargileukin alfa
6313:
6312:
6206:
6205:
6164:
6163:
6061:
6060:
6057:
6056:
5865:
5864:
5543:
5542:
5198:
5197:
4987:Media related to
4954:(12): 1093–1101.
4671:10.1159/000063553
4552:BMC Biotechnology
4138:(10): 1341–1346.
3549:(Pt 1): 287–291.
3410:(10): 1095–1104.
3404:Nature Immunology
3294:(14): 3570–3581.
2928:(12): 5936–5944.
2788:(12): 1666–1668.
2590:(14): 5761–5766.
2541:(10): 1977–1989.
2459:(10): 2991–3001.
1739:physical exercise
1696:allergic reaction
1578:beta-2 adrenergic
1537:, namely type-II
1399:), also known as
1390:
1389:
1386:
1385:
1359:
1358:
1324:
1323:
1303:
1302:
1277:
1276:
1256:
1255:
1230:
1229:
1211:
1210:
1185:
1184:
1166:
1165:
1140:
1139:
1121:
1120:
1069:
1068:
642:cytokine activity
609:
608:
605:
604:
574:
573:
561:
560:
534:entorhinal cortex
499:
498:
472:left uterine tube
397:
396:
296:
295:
123:
122:
119:
118:
63:Ortholog search:
16:(Redirected from
7613:
7576:Efineptakin alfa
7571:Efavaleukin alfa
7473:
6440:Decoy receptors:
6340:
6333:
6326:
6317:
5944:
5876:
5659:
5644:
5256:
5247:
5225:
5218:
5211:
5202:
5184:
5169:
5154:
5139:
5124:
5109:
5094:
5079:
5064:
5049:
5029:
5022:
5015:
5006:
4986:
4971:
4942:
4932:
4899:
4889:
4880:(4): 1216–1233.
4864:
4835:
4806:
4777:
4748:
4719:
4702:(4–5): 403–412.
4690:
4653:
4624:
4587:
4577:
4567:
4533:
4532:
4522:
4498:
4492:
4491:
4455:
4449:
4448:
4438:
4414:
4408:
4407:
4397:
4373:
4367:
4366:
4356:
4346:
4314:
4308:
4301:
4295:
4294:
4292:
4291:
4267:
4254:
4253:
4243:
4211:
4202:
4201:
4191:
4182:(5): 2783–2789.
4167:
4158:
4157:
4147:
4123:
4117:
4116:
4088:
4082:
4081:
4060:
4054:
4053:
4030:Gastroenterology
4021:
4015:
4014:
3997:(6): 1461–1472.
3991:Gastroenterology
3985:
3979:
3978:
3961:(6): 1473–1482.
3955:Gastroenterology
3949:
3943:
3942:
3914:
3908:
3907:
3900:
3894:
3893:
3857:
3851:
3850:
3840:
3808:
3802:
3801:
3764:
3758:
3757:
3739:
3711:
3705:
3704:
3668:
3659:
3658:
3648:
3639:(4): 1106–1117.
3624:
3618:
3617:
3607:
3583:
3577:
3576:
3566:
3534:
3528:
3527:
3491:
3485:
3484:
3474:
3442:
3436:
3435:
3399:
3393:
3392:
3364:
3358:
3357:
3347:
3323:
3314:
3313:
3303:
3279:
3270:
3269:
3232:
3226:
3225:
3215:
3206:(7): 2143–2151.
3191:
3185:
3184:
3166:
3157:(3): 1723–1729.
3142:
3136:
3135:
3099:
3093:
3092:
3082:
3058:
3052:
3051:
3041:
3009:
3003:
3002:
2992:
2975:(9): 5249–5263.
2960:
2954:
2953:
2917:
2908:
2907:
2882:(1–2): 165–168.
2871:
2860:
2859:
2849:
2840:(6): 1683–1690.
2825:
2816:
2815:
2797:
2773:
2764:
2763:
2753:
2721:
2712:
2711:
2701:
2684:(5): 1209–1220.
2669:
2663:
2662:
2634:
2628:
2627:
2617:
2607:
2575:
2569:
2568:
2558:
2535:The EMBO Journal
2526:
2520:
2519:
2509:
2485:
2479:
2478:
2468:
2444:
2438:
2437:
2419:
2391:
2382:
2381:
2371:
2361:
2329:
2323:
2322:
2312:
2302:
2274:
2268:
2267:
2257:
2225:
2219:
2218:
2208:
2176:
2170:
2169:
2141:
2135:
2134:
2124:
2092:
2086:
2085:
2075:
2051:
2045:
2044:
2034:
2002:
1993:
1992:
1956:
1947:
1946:
1935:
1929:
1928:
1917:
1911:
1901:
1890:
1880:
1677:Effect on tumors
1669:(TLR) triggered
1619:AU-rich elements
1489:(IFN-gamma) and
1428:STAT3 signalling
1424:IL-10 receptor-2
1420:IL-10 receptor-1
1372:
1371:
1343:
1336:
1319:
1307:
1298:
1286:
1282:RefSeq (protein)
1272:
1260:
1251:
1239:
1215:
1196:
1170:
1151:
1125:
1106:
1075:
615:
601:
592:
585:
570:
554:stria vascularis
510:
508:Top expressed in
503:
464:cartilage tissue
448:
446:Top expressed in
441:
420:
403:
393:
380:
369:
354:
347:
341:
330:
318:
302:
292:
279:
268:
253:
246:
240:
229:
215:
199:
193:
191:IL10 - orthologs
144:
137:
114:
77:
71:
50:
49:
44:
32:
21:
7621:
7620:
7616:
7615:
7614:
7612:
7611:
7610:
7591:
7590:
7589:
7580:
7491:
7464:
7415:
7394:
7373:
7333:
7312:
7256:
7253:(against IL-22)
7224:
7183:
7180:(against IL-20)
7141:
7095:
7014:
6988:
6932:
6891:
6865:
6839:
6808:
6788:
6767:
6686:
6625:
6569:
6523:
6447:
6352:
6344:
6314:
6309:
6275:
6254:
6212:
6202:
6160:
6133:
6053:
6035:
5933:
5861:
5830:
5793:
5731:
5703:
5654:
5652:
5650:
5633:
5539:
5518:
5502:
5405:
5238:
5229:
5199:
5194:
5191:
5185:
5176:
5170:
5161:
5155:
5146:
5140:
5131:
5125:
5116:
5110:
5101:
5095:
5086:
5080:
5071:
5065:
5056:
5050:
5036:
5033:
4979:
4974:
4945:
4902:
4867:
4838:
4809:
4780:
4751:
4722:
4693:
4656:
4627:
4590:
4545:
4541:
4539:Further reading
4536:
4500:
4499:
4495:
4457:
4456:
4452:
4416:
4415:
4411:
4375:
4374:
4370:
4316:
4315:
4311:
4302:
4298:
4289:
4287:
4269:
4268:
4257:
4213:
4212:
4205:
4169:
4168:
4161:
4125:
4124:
4120:
4090:
4089:
4085:
4062:
4061:
4057:
4023:
4022:
4018:
3987:
3986:
3982:
3951:
3950:
3946:
3916:
3915:
3911:
3902:
3901:
3897:
3859:
3858:
3854:
3810:
3809:
3805:
3766:
3765:
3761:
3713:
3712:
3708:
3670:
3669:
3662:
3626:
3625:
3621:
3585:
3584:
3580:
3536:
3535:
3531:
3493:
3492:
3488:
3444:
3443:
3439:
3401:
3400:
3396:
3375:(12): 948–955.
3366:
3365:
3361:
3325:
3324:
3317:
3288:Cancer Research
3281:
3280:
3273:
3234:
3233:
3229:
3193:
3192:
3188:
3144:
3143:
3139:
3101:
3100:
3096:
3060:
3059:
3055:
3011:
3010:
3006:
2962:
2961:
2957:
2919:
2918:
2911:
2873:
2872:
2863:
2827:
2826:
2819:
2775:
2774:
2767:
2723:
2722:
2715:
2671:
2670:
2666:
2636:
2635:
2631:
2577:
2576:
2572:
2528:
2527:
2523:
2487:
2486:
2482:
2446:
2445:
2441:
2408:10.1038/nri2711
2393:
2392:
2385:
2331:
2330:
2326:
2282:
2276:
2275:
2271:
2227:
2226:
2222:
2197:10.1038/nm.2106
2185:Nature Medicine
2178:
2177:
2173:
2143:
2142:
2138:
2094:
2093:
2089:
2053:
2052:
2048:
2004:
2003:
1996:
1958:
1957:
1950:
1937:
1936:
1932:
1919:
1918:
1914:
1902:
1893:
1881:
1872:
1868:
1849:
1824:
1822:PEGylated forms
1808:Crohn's disease
1801:
1688:
1686:Role in disease
1679:
1635:
1585:stimulation of
1544:
1515:
1444:
1432:phosphorylation
1381:View/Edit Mouse
1376:View/Edit Human
1339:
1332:
1329:Location (UCSC)
1315:
1294:
1268:
1247:
1160:ENSG00000136634
1053:
874:immune response
677:
656:
632:protein binding
597:
566:
557:
552:
548:
544:
540:
536:
532:
528:
524:
520:
506:
495:
490:
486:
482:
478:
474:
470:
466:
462:
458:
444:
388:
375:
367:
357:
356:
355:
348:
328:
305:Gene location (
287:
274:
266:
256:
255:
254:
247:
225:
202:Gene location (
153:
140:
133:
86:
64:
28:
23:
22:
15:
12:
11:
5:
7619:
7617:
7609:
7608:
7603:
7593:
7592:
7586:
7585:
7582:
7581:
7579:
7578:
7573:
7564:
7563:
7561:Interleukin 35
7558:
7551:Interleukin 34
7548:
7546:Interleukin 32
7543:
7532:Interleukin 26
7529:
7518:Interleukin 24
7515:
7508:Interleukin 16
7505:
7499:
7497:
7493:
7492:
7490:
7489:
7481:
7479:
7470:
7466:
7465:
7463:
7462:
7453:
7452:
7450:Interleukin 38
7447:
7432:Interleukin 36
7425:
7423:
7417:
7416:
7414:
7413:
7411:Interleukin 33
7404:
7402:
7396:
7395:
7393:
7392:
7390:Interleukin 31
7383:
7381:
7375:
7374:
7372:
7371:
7366:
7355:Interleukin 28
7352:
7343:
7341:
7335:
7334:
7332:
7331:
7322:
7320:
7314:
7313:
7311:
7310:
7305:
7300:
7295:
7290:
7285:
7276:
7275:
7266:
7264:
7258:
7257:
7255:
7254:
7244:
7243:
7241:Interleukin 22
7234:
7232:
7226:
7225:
7223:
7222:
7217:
7208:
7207:
7205:Interleukin 21
7202:
7193:
7191:
7185:
7184:
7182:
7181:
7171:
7170:
7168:Interleukin 24
7165:
7163:Interleukin 20
7160:
7158:Interleukin 19
7151:
7149:
7143:
7142:
7140:
7139:
7130:
7129:
7124:
7122:Interleukin 37
7119:
7117:Interleukin 18
7114:
7105:
7103:
7097:
7096:
7094:
7093:
7088:
7083:
7078:
7073:
7068:
7059:
7058:
7031:Interleukin 17
7024:
7022:
7016:
7015:
7013:
7012:
7010:Interleukin 15
7007:
6998:
6996:
6990:
6989:
6987:
6986:
6981:
6976:
6967:
6966:
6964:Interleukin 13
6961:
6956:
6951:
6942:
6940:
6934:
6933:
6931:
6930:
6925:
6916:
6915:
6913:Interleukin 12
6910:
6901:
6899:
6893:
6892:
6890:
6889:
6884:
6875:
6873:
6867:
6866:
6864:
6863:
6858:
6849:
6847:
6841:
6840:
6838:
6837:
6828:
6827:
6818:
6816:
6810:
6809:
6807:
6806:
6798:
6796:
6790:
6789:
6787:
6786:
6777:
6775:
6769:
6768:
6766:
6765:
6760:
6755:
6750:
6745:
6740:
6735:
6730:
6725:
6720:
6711:
6710:
6705:
6696:
6694:
6688:
6687:
6685:
6684:
6675:
6674:
6669:
6664:
6655:
6654:
6645:
6644:
6635:
6633:
6627:
6626:
6624:
6623:
6618:
6609:
6608:
6599:
6598:
6596:Interleukin 13
6593:
6588:
6579:
6577:
6571:
6570:
6568:
6567:
6565:Promegapoietin
6562:
6557:
6552:
6547:
6542:
6533:
6531:
6525:
6524:
6522:
6521:
6516:
6511:
6502:
6501:
6496:
6491:
6489:Pegaldesleukin
6486:
6481:
6476:
6471:
6466:
6457:
6455:
6449:
6448:
6446:
6445:
6436:
6435:
6430:
6425:
6416:
6415:
6410:
6405:
6400:
6391:
6390:
6385:
6380:
6362:
6360:
6354:
6353:
6345:
6343:
6342:
6335:
6328:
6320:
6311:
6310:
6308:
6307:
6306:
6305:
6304:
6303:
6298:
6293:
6288:
6283:
6273:
6269:
6268:
6267:
6262:
6252:
6243:
6237:
6236:
6235:
6234:
6229:
6216:
6214:
6208:
6207:
6204:
6203:
6201:
6200:
6195:
6190:
6189:
6188:
6183:
6172:
6170:
6166:
6165:
6162:
6161:
6159:
6158:
6143:
6141:
6135:
6134:
6132:
6131:
6126:
6121:
6116:
6111:
6106:
6101:
6096:
6091:
6086:
6081:
6071:
6069:
6067:Ig superfamily
6063:
6062:
6059:
6058:
6055:
6054:
6052:
6051:
6045:
6043:
6037:
6036:
6034:
6033:
6028:
6023:
6018:
6013:
6008:
6003:
5998:
5993:
5988:
5983:
5978:
5973:
5968:
5963:
5958:
5952:
5950:
5941:
5935:
5934:
5932:
5931:
5930:
5929:
5924:
5914:
5909:
5904:
5899:
5894:
5884:
5882:
5873:
5867:
5866:
5863:
5862:
5860:
5859:
5854:
5849:
5844:
5838:
5836:
5832:
5831:
5829:
5828:
5823:
5818:
5813:
5807:
5805:
5795:
5794:
5792:
5791:
5790:
5789:
5784:
5779:
5774:
5763:
5758:
5753:
5748:
5742:
5740:
5733:
5732:
5730:
5729:
5724:
5719:
5713:
5711:
5705:
5704:
5702:
5701:
5696:
5691:
5686:
5677:
5667:
5665:
5656:
5641:
5635:
5634:
5632:
5631:
5626:
5621:
5616:
5611:
5606:
5601:
5596:
5591:
5586:
5581:
5576:
5575:
5574:
5569:
5559:
5553:
5551:
5545:
5544:
5541:
5540:
5538:
5537:
5532:
5526:
5524:
5520:
5519:
5517:
5516:
5510:
5508:
5504:
5503:
5501:
5500:
5495:
5490:
5485:
5480:
5475:
5470:
5465:
5460:
5455:
5450:
5445:
5440:
5435:
5430:
5425:
5420:
5413:
5411:
5407:
5406:
5404:
5403:
5398:
5393:
5388:
5383:
5378:
5373:
5368:
5363:
5358:
5353:
5347:
5342:
5337:
5332:
5327:
5322:
5317:
5312:
5307:
5302:
5297:
5292:
5286:
5280:
5274:
5268:
5262:
5260:
5253:
5244:
5240:
5239:
5232:Cell signaling
5230:
5228:
5227:
5220:
5213:
5205:
5196:
5195:
5193:
5192:
5186:
5179:
5177:
5171:
5164:
5162:
5156:
5149:
5147:
5141:
5134:
5132:
5126:
5119:
5117:
5111:
5104:
5102:
5096:
5089:
5087:
5081:
5074:
5072:
5066:
5059:
5057:
5051:
5044:
5041:
5038:
5037:
5034:
5032:
5031:
5024:
5017:
5009:
5003:
5002:
4995:Interleukin-10
4992:
4978:
4977:External links
4975:
4973:
4972:
4943:
4900:
4865:
4847:(2): 185–192.
4836:
4818:(4): 287–289.
4807:
4789:(4): 281–285.
4778:
4760:(4): 269–272.
4749:
4720:
4691:
4665:(5): 485–488.
4654:
4636:(1): 683–765.
4625:
4588:
4542:
4540:
4537:
4535:
4534:
4513:(1): 134–141.
4493:
4450:
4409:
4368:
4309:
4296:
4255:
4226:(2): 191–195.
4203:
4159:
4118:
4099:(2): 187–192.
4083:
4072:(4): 648–651.
4055:
4036:(2): 383–389.
4016:
3980:
3944:
3925:(6): 754–759.
3909:
3895:
3852:
3803:
3759:
3722:(3): 447–457.
3706:
3660:
3619:
3598:(5): 554–561.
3578:
3529:
3502:(6): 512–515.
3486:
3457:(2): 128–135.
3437:
3416:10.1038/ni1503
3394:
3359:
3338:(6): 781–796.
3315:
3271:
3244:(1): 231–238.
3227:
3186:
3137:
3110:(2): 208–214.
3094:
3073:(4): 624–629.
3053:
3024:(2): 579–584.
3004:
2955:
2909:
2861:
2817:
2765:
2736:(4): 915–924.
2713:
2664:
2645:(1): 683–765.
2629:
2570:
2521:
2500:(1): 292–296.
2480:
2439:
2402:(3): 170–181.
2383:
2324:
2293:(6): 414–428.
2280:
2269:
2220:
2191:(4): 452–459.
2171:
2152:(1): 929–979.
2136:
2087:
2066:(6): 591–601.
2046:
2017:(1): 205–218.
1994:
1967:(2): 120–128.
1961:Immunogenetics
1948:
1930:
1912:
1891:
1869:
1867:
1864:
1848:
1845:
1823:
1820:
1800:
1797:
1781:gastric cancer
1687:
1684:
1678:
1675:
1634:
1631:
1615:mRNA stability
1542:
1539:T helper cells
1514:
1511:
1443:
1440:
1407:), is an anti-
1393:Interleukin 10
1388:
1387:
1384:
1383:
1378:
1368:
1367:
1361:
1360:
1357:
1356:
1354:
1352:
1345:
1344:
1337:
1330:
1326:
1325:
1322:
1321:
1311:
1310:
1304:
1301:
1300:
1290:
1289:
1283:
1279:
1278:
1275:
1274:
1264:
1263:
1257:
1254:
1253:
1243:
1242:
1236:
1232:
1231:
1228:
1227:
1219:
1218:
1212:
1209:
1208:
1200:
1199:
1193:
1187:
1186:
1183:
1182:
1174:
1173:
1167:
1164:
1163:
1155:
1154:
1148:
1142:
1141:
1138:
1137:
1129:
1128:
1122:
1119:
1118:
1110:
1109:
1103:
1097:
1096:
1091:
1086:
1082:
1081:
1071:
1070:
1067:
1066:
1055:
1054:
1052:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
685:
683:
679:
678:
676:
675:
670:
664:
662:
658:
657:
655:
654:
649:
644:
639:
634:
628:
626:
622:
621:
611:
610:
607:
606:
603:
602:
594:
593:
582:
576:
575:
572:
571:
563:
562:
559:
558:
556:
555:
551:
547:
543:
539:
535:
531:
527:
523:
519:
515:
512:
511:
500:
497:
496:
494:
493:
489:
485:
481:
480:gastric mucosa
477:
473:
469:
465:
461:
457:
453:
450:
449:
437:
436:
428:
417:
411:
410:
407:RNA expression
399:
398:
395:
394:
386:
382:
381:
373:
370:
365:
359:
358:
349:
342:
336:
332:
331:
326:
320:
319:
311:
310:
298:
297:
294:
293:
285:
281:
280:
272:
269:
264:
258:
257:
248:
241:
235:
231:
230:
223:
217:
216:
208:
207:
195:
194:
151:
147:
146:
138:
130:
129:
125:
124:
121:
120:
117:
116:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
18:Interleukin-10
14:
13:
10:
9:
6:
4:
3:
2:
7618:
7607:
7604:
7602:
7599:
7598:
7596:
7577:
7574:
7572:
7569:
7566:
7565:
7562:
7559:
7556:
7552:
7549:
7547:
7544:
7541:
7537:
7533:
7530:
7527:
7523:
7519:
7516:
7513:
7509:
7506:
7504:
7501:
7500:
7498:
7494:
7487:
7483:
7482:
7480:
7478:
7474:
7471:
7467:
7461:
7458:
7455:
7454:
7451:
7448:
7445:
7441:
7437:
7433:
7430:
7427:
7426:
7424:
7422:
7418:
7412:
7409:
7406:
7405:
7403:
7401:
7397:
7391:
7388:
7385:
7384:
7382:
7380:
7376:
7370:
7367:
7364:
7360:
7356:
7353:
7351:
7348:
7345:
7344:
7342:
7340:
7336:
7330:
7327:
7324:
7323:
7321:
7319:
7315:
7309:
7306:
7304:
7303:Tildrakizumab
7301:
7299:
7296:
7294:
7291:
7289:
7286:
7284:
7281:
7278:
7277:
7274:
7271:
7268:
7267:
7265:
7263:
7259:
7252:
7249:
7246:
7245:
7242:
7239:
7236:
7235:
7233:
7231:
7227:
7221:
7218:
7216:
7213:
7210:
7209:
7206:
7203:
7201:
7198:
7195:
7194:
7192:
7190:
7186:
7179:
7176:
7173:
7172:
7169:
7166:
7164:
7161:
7159:
7156:
7153:
7152:
7150:
7148:
7144:
7138:
7135:
7132:
7131:
7128:
7125:
7123:
7120:
7118:
7115:
7113:
7110:
7107:
7106:
7104:
7102:
7098:
7092:
7089:
7087:
7084:
7082:
7079:
7077:
7074:
7072:
7069:
7067:
7064:
7061:
7060:
7056:
7052:
7048:
7044:
7040:
7036:
7032:
7029:
7026:
7025:
7023:
7021:
7017:
7011:
7008:
7006:
7003:
7000:
6999:
6997:
6995:
6991:
6985:
6982:
6980:
6977:
6975:
6972:
6969:
6968:
6965:
6962:
6960:
6959:Interleukin 4
6957:
6955:
6952:
6950:
6947:
6944:
6943:
6941:
6939:
6935:
6929:
6926:
6924:
6921:
6918:
6917:
6914:
6911:
6909:
6908:Edodekin alfa
6906:
6903:
6902:
6900:
6898:
6894:
6888:
6885:
6883:
6880:
6877:
6876:
6874:
6872:
6868:
6862:
6859:
6857:
6854:
6851:
6850:
6848:
6846:
6842:
6836:
6833:
6830:
6829:
6826:
6825:Interleukin 9
6823:
6820:
6819:
6817:
6815:
6811:
6804:
6800:
6799:
6797:
6795:
6791:
6785:
6784:Interleukin 7
6782:
6779:
6778:
6776:
6774:
6770:
6764:
6761:
6759:
6756:
6754:
6751:
6749:
6746:
6744:
6741:
6739:
6736:
6734:
6731:
6729:
6726:
6724:
6721:
6719:
6716:
6713:
6712:
6709:
6708:Interleukin 6
6706:
6704:
6703:Atexakin alfa
6701:
6698:
6697:
6695:
6693:
6689:
6683:
6680:
6677:
6676:
6673:
6670:
6668:
6665:
6663:
6660:
6657:
6656:
6653:
6650:
6647:
6646:
6643:
6642:Interleukin 5
6640:
6637:
6636:
6634:
6632:
6628:
6622:
6619:
6617:
6614:
6611:
6610:
6607:
6604:
6601:
6600:
6597:
6594:
6592:
6591:Interleukin 4
6589:
6587:
6584:
6581:
6580:
6578:
6576:
6572:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6546:
6545:Interleukin 3
6543:
6541:
6538:
6535:
6534:
6532:
6530:
6526:
6520:
6517:
6515:
6512:
6510:
6507:
6504:
6503:
6500:
6497:
6495:
6492:
6490:
6487:
6485:
6484:Interleukin 2
6482:
6480:
6477:
6475:
6472:
6470:
6467:
6465:
6462:
6459:
6458:
6456:
6454:
6450:
6444:
6441:
6438:
6437:
6434:
6431:
6429:
6426:
6424:
6421:
6418:
6417:
6414:
6411:
6409:
6406:
6404:
6401:
6399:
6396:
6393:
6392:
6389:
6386:
6384:
6381:
6378:
6374:
6370:
6369:Interleukin 1
6367:
6364:
6363:
6361:
6359:
6355:
6351:
6348:
6341:
6336:
6334:
6329:
6327:
6322:
6321:
6318:
6302:
6299:
6297:
6294:
6292:
6289:
6287:
6284:
6282:
6279:
6278:
6277:
6270:
6266:
6263:
6261:
6258:
6257:
6256:
6249:
6248:
6247:
6244:
6242:
6239:
6238:
6233:
6230:
6228:
6225:
6224:
6223:
6222:
6218:
6217:
6215:
6209:
6199:
6196:
6194:
6191:
6187:
6184:
6182:
6179:
6178:
6177:
6176:Hematopoietic
6174:
6173:
6171:
6167:
6156:
6152:
6148:
6145:
6144:
6142:
6140:
6136:
6130:
6127:
6125:
6122:
6120:
6117:
6115:
6112:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6076:
6073:
6072:
6070:
6068:
6064:
6050:
6047:
6046:
6044:
6042:
6038:
6032:
6029:
6027:
6024:
6022:
6019:
6017:
6014:
6012:
6009:
6007:
6004:
6002:
5999:
5997:
5994:
5992:
5989:
5987:
5984:
5982:
5979:
5977:
5974:
5972:
5969:
5967:
5964:
5962:
5959:
5957:
5954:
5953:
5951:
5949:
5945:
5942:
5940:
5936:
5928:
5925:
5923:
5920:
5919:
5918:
5915:
5913:
5910:
5908:
5905:
5903:
5900:
5898:
5895:
5893:
5889:
5886:
5885:
5883:
5881:
5877:
5874:
5872:
5868:
5858:
5855:
5853:
5850:
5848:
5845:
5843:
5840:
5839:
5837:
5833:
5827:
5824:
5822:
5819:
5817:
5814:
5812:
5809:
5808:
5806:
5804:
5800:
5796:
5788:
5785:
5783:
5780:
5778:
5775:
5773:
5769:
5768:
5767:
5764:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5743:
5741:
5739:
5734:
5728:
5725:
5723:
5720:
5718:
5715:
5714:
5712:
5710:
5706:
5700:
5697:
5695:
5692:
5690:
5687:
5685:
5681:
5678:
5676:
5672:
5669:
5668:
5666:
5664:
5660:
5657:
5649:
5645:
5642:
5640:
5636:
5630:
5627:
5625:
5622:
5620:
5617:
5615:
5612:
5610:
5607:
5605:
5602:
5600:
5597:
5595:
5592:
5590:
5587:
5585:
5584:TNFSF5/CD40LG
5582:
5580:
5577:
5573:
5570:
5568:
5565:
5564:
5563:
5560:
5558:
5555:
5554:
5552:
5550:
5546:
5536:
5533:
5531:
5528:
5527:
5525:
5521:
5515:
5512:
5511:
5509:
5505:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5479:
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5474:
5471:
5469:
5466:
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5461:
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5449:
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5441:
5439:
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5429:
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5424:
5421:
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5414:
5412:
5408:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
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5343:
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5338:
5336:
5333:
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5321:
5318:
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5308:
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5264:
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4336:
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4324:
4320:
4313:
4310:
4307:
4306:
4300:
4297:
4286:on 2015-12-22
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3509:
3505:
3501:
3497:
3490:
3487:
3482:
3478:
3473:
3468:
3464:
3460:
3456:
3452:
3448:
3441:
3438:
3433:
3429:
3425:
3421:
3417:
3413:
3409:
3405:
3398:
3395:
3390:
3386:
3382:
3378:
3374:
3370:
3363:
3360:
3355:
3351:
3346:
3341:
3337:
3333:
3329:
3322:
3320:
3316:
3311:
3307:
3302:
3297:
3293:
3289:
3285:
3278:
3276:
3272:
3267:
3263:
3259:
3255:
3251:
3247:
3243:
3239:
3231:
3228:
3223:
3219:
3214:
3209:
3205:
3201:
3197:
3190:
3187:
3182:
3178:
3174:
3170:
3165:
3160:
3156:
3152:
3148:
3141:
3138:
3133:
3129:
3125:
3121:
3117:
3113:
3109:
3105:
3098:
3095:
3090:
3086:
3081:
3076:
3072:
3068:
3064:
3057:
3054:
3049:
3045:
3040:
3035:
3031:
3027:
3023:
3019:
3015:
3008:
3005:
3000:
2996:
2991:
2986:
2982:
2978:
2974:
2970:
2966:
2959:
2956:
2951:
2947:
2943:
2939:
2935:
2931:
2927:
2923:
2916:
2914:
2910:
2905:
2901:
2897:
2893:
2889:
2885:
2881:
2877:
2870:
2868:
2866:
2862:
2857:
2853:
2848:
2843:
2839:
2835:
2831:
2824:
2822:
2818:
2813:
2809:
2805:
2801:
2796:
2791:
2787:
2783:
2782:FASEB Journal
2779:
2772:
2770:
2766:
2761:
2757:
2752:
2747:
2743:
2739:
2735:
2731:
2727:
2720:
2718:
2714:
2709:
2705:
2700:
2695:
2691:
2687:
2683:
2679:
2675:
2668:
2665:
2660:
2656:
2652:
2648:
2644:
2640:
2633:
2630:
2625:
2621:
2616:
2611:
2606:
2601:
2597:
2593:
2589:
2585:
2581:
2574:
2571:
2566:
2562:
2557:
2552:
2548:
2544:
2540:
2536:
2532:
2525:
2522:
2517:
2513:
2508:
2503:
2499:
2495:
2491:
2484:
2481:
2476:
2472:
2467:
2462:
2458:
2454:
2450:
2443:
2440:
2435:
2431:
2427:
2423:
2418:
2413:
2409:
2405:
2401:
2397:
2390:
2388:
2384:
2379:
2375:
2370:
2365:
2360:
2355:
2351:
2347:
2344:(3): e33628.
2343:
2339:
2335:
2328:
2325:
2320:
2316:
2311:
2306:
2301:
2296:
2292:
2288:
2284:
2273:
2270:
2265:
2261:
2256:
2251:
2247:
2243:
2239:
2235:
2231:
2224:
2221:
2216:
2212:
2207:
2202:
2198:
2194:
2190:
2186:
2182:
2175:
2172:
2167:
2163:
2159:
2155:
2151:
2147:
2140:
2137:
2132:
2128:
2123:
2118:
2114:
2110:
2106:
2102:
2098:
2091:
2088:
2083:
2079:
2074:
2069:
2065:
2061:
2057:
2050:
2047:
2042:
2038:
2033:
2028:
2024:
2020:
2016:
2012:
2008:
2001:
1999:
1995:
1990:
1986:
1982:
1978:
1974:
1970:
1966:
1962:
1955:
1953:
1949:
1944:
1940:
1934:
1931:
1926:
1922:
1916:
1913:
1909:
1905:
1900:
1898:
1896:
1892:
1888:
1884:
1879:
1877:
1875:
1871:
1865:
1863:
1860:
1858:
1854:
1846:
1844:
1842:
1841:pegilodecakin
1838:
1834:
1829:
1821:
1819:
1815:
1813:
1809:
1805:
1798:
1796:
1792:
1790:
1786:
1782:
1778:
1774:
1770:
1765:
1763:
1759:
1754:
1751:
1747:
1742:
1740:
1736:
1731:
1727:
1724:
1720:
1716:
1712:
1708:
1704:
1699:
1697:
1693:
1685:
1683:
1676:
1674:
1672:
1668:
1662:
1660:
1656:
1652:
1648:
1644:
1640:
1632:
1630:
1628:
1624:
1620:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1552:
1548:
1540:
1536:
1532:
1528:
1524:
1520:
1512:
1510:
1508:
1504:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1472:
1468:
1464:
1460:
1455:
1453:
1449:
1441:
1439:
1437:
1433:
1429:
1425:
1421:
1417:
1413:
1410:
1406:
1402:
1398:
1394:
1382:
1377:
1373:
1369:
1366:
1362:
1355:
1353:
1350:
1346:
1342:
1338:
1335:
1331:
1327:
1320:
1318:
1312:
1308:
1305:
1299:
1297:
1291:
1287:
1284:
1280:
1273:
1271:
1265:
1261:
1258:
1252:
1250:
1244:
1240:
1237:
1235:RefSeq (mRNA)
1233:
1226:
1225:
1220:
1216:
1213:
1207:
1206:
1201:
1197:
1194:
1192:
1188:
1181:
1180:
1175:
1171:
1168:
1162:
1161:
1156:
1152:
1149:
1147:
1143:
1136:
1135:
1130:
1126:
1123:
1117:
1116:
1111:
1107:
1104:
1102:
1098:
1095:
1092:
1090:
1087:
1083:
1080:
1076:
1072:
1065:
1061:
1056:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
686:
684:
681:
680:
674:
671:
669:
666:
665:
663:
660:
659:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
629:
627:
624:
623:
620:
619:Gene ontology
616:
612:
600:
595:
591:
586:
583:
581:
577:
569:
564:
553:
549:
545:
541:
537:
533:
529:
525:
521:
517:
516:
513:
509:
504:
501:
491:
487:
483:
479:
475:
471:
467:
463:
459:
455:
454:
451:
447:
442:
439:
438:
435:
433:
429:
427:
426:
422:
421:
418:
416:
412:
408:
404:
400:
392:
387:
383:
379:
374:
364:
360:
353:
346:
340:
333:
325:
321:
317:
312:
308:
303:
299:
291:
286:
282:
278:
273:
263:
259:
252:
245:
239:
232:
228:
222:
218:
214:
209:
205:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
148:
143:
136:
131:
126:
115:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
7606:Interleukins
7567:
7555:M-CSFR/CSF1R
7542:heterodimer)
7528:heterodimer)
7457:Antagonists:
7456:
7428:
7407:
7386:
7346:
7325:
7298:Risankizumab
7279:
7269:
7247:
7237:
7220:NNC0114-0006
7215:NNC0114-0005
7211:
7196:
7174:
7154:
7133:
7108:
7062:
7027:
7001:
6984:Tralokinumab
6979:Lebrikizumab
6974:Anrukinzumab
6970:
6945:
6919:
6904:
6878:
6860:
6852:
6831:
6821:
6780:
6723:Clazakizumab
6714:
6699:
6678:
6662:Benralizumab
6658:
6649:Antagonists:
6648:
6638:
6621:Pascolizumab
6612:
6603:Antagonists:
6602:
6582:
6536:
6505:
6460:
6439:
6419:
6395:Antagonists:
6394:
6365:
6295:
6271:
6250:
6219:
6211:By function/
5922:IL28/IFNL2+3
5887:
5187:
5172:
5157:
5142:
5127:
5112:
5097:
5082:
5067:
5052:
4951:
4947:
4912:
4908:
4877:
4873:
4844:
4840:
4815:
4811:
4786:
4782:
4757:
4753:
4731:(1): 36–43.
4728:
4724:
4699:
4695:
4662:
4658:
4633:
4629:
4596:
4592:
4555:
4551:
4510:
4506:
4496:
4463:
4459:
4453:
4426:
4422:
4412:
4388:(1): 35–46.
4385:
4381:
4371:
4326:
4322:
4312:
4304:
4299:
4288:. Retrieved
4284:the original
4279:
4275:
4223:
4219:
4179:
4175:
4135:
4131:
4121:
4096:
4092:
4086:
4069:
4065:
4058:
4033:
4029:
4019:
3994:
3990:
3983:
3958:
3954:
3947:
3922:
3918:
3912:
3898:
3865:
3861:
3855:
3820:
3816:
3806:
3773:
3769:
3762:
3737:10533/132162
3719:
3715:
3709:
3679:(1): 26–34.
3676:
3672:
3636:
3632:
3622:
3595:
3591:
3581:
3546:
3542:
3532:
3499:
3495:
3489:
3454:
3450:
3440:
3407:
3403:
3397:
3372:
3368:
3362:
3335:
3331:
3291:
3287:
3241:
3237:
3230:
3203:
3199:
3189:
3154:
3150:
3140:
3107:
3103:
3097:
3070:
3066:
3056:
3021:
3017:
3007:
2972:
2968:
2958:
2925:
2921:
2879:
2875:
2837:
2833:
2785:
2781:
2733:
2729:
2681:
2677:
2667:
2642:
2638:
2632:
2587:
2583:
2573:
2538:
2534:
2524:
2497:
2493:
2483:
2456:
2452:
2442:
2399:
2395:
2341:
2337:
2327:
2290:
2286:
2272:
2237:
2233:
2223:
2188:
2184:
2174:
2149:
2145:
2139:
2107:(1): 15–28.
2104:
2100:
2090:
2063:
2059:
2049:
2014:
2010:
1964:
1960:
1942:
1933:
1924:
1915:
1861:
1850:
1847:Interactions
1836:
1832:
1825:
1816:
1802:
1793:
1766:
1755:
1743:
1732:
1728:
1700:
1689:
1680:
1663:
1647:MHC class II
1636:
1629:or miR-106.
1523:chromosome 1
1518:
1516:
1456:
1445:
1415:
1409:inflammatory
1404:
1400:
1396:
1392:
1391:
1314:
1293:
1267:
1246:
1222:
1203:
1177:
1158:
1132:
1113:
1093:
1088:
759:human ageing
430:
423:
389:130,952,711
376:130,947,582
288:206,774,541
275:206,767,602
150:External IDs
85:
29:
7308:Ustekinumab
7288:Briakinumab
7280:Antibodies:
7251:Fezakinumab
7248:Antibodies:
7212:Antibodies:
7200:Denenicokin
7175:Antibodies:
7112:Iboctadekin
7091:Vunakizumab
7086:Secukinumab
7076:Perakizumab
7063:Antibodies:
6971:Antibodies:
6928:Ustekinumab
6923:Briakinumab
6920:Antibodies:
6832:Antibodies:
6758:Tocilizumab
6728:Elsilimomab
6715:Antibodies:
6667:Mepolizumab
6659:Antibodies:
6613:Antibodies:
6540:Daniplestim
6509:Basiliximab
6506:Antibodies:
6474:Celmoleukin
6469:Aldesleukin
6433:Lutikizumab
6428:Gevokizumab
6423:Canakinumab
6420:Antibodies:
6139:IL17 family
5880:IL10 family
5799:IL12 family
5651:(grouped by
5639:Interleukin
5562:Lymphotoxin
5035:PDB gallery
3823:: 437–457.
3332:Cancer Cell
2240:: 176–185.
1723:macrophages
1651:macrophages
1645:cytokines,
1639:pleiotropic
1591:Fc receptor
1535:lymphocytes
704:hemopoiesis
492:granulocyte
460:gallbladder
128:Identifiers
7595:Categories
7363:B (IFN-λ3)
7359:A (IFN-λ2)
7293:Guselkumab
7283:Brazikumab
7178:Fletikumab
7081:Remtolumab
7071:Ixekizumab
7066:Brodalumab
6949:Binetrakin
6887:Oprelvekin
6856:Ilodecakin
6835:Enokizumab
6748:Siltuximab
6738:Olokizumab
6672:Reslizumab
6606:Pitrakinra
6586:Binetrakin
6555:Milodistim
6550:Leridistim
6519:Inolimomab
6494:Teceleukin
6413:Isunakinra
6350:modulators
6246:Lymphokine
6084:IL1B/IL1F2
6079:IL1A/IL1F1
6075:IL1 family
5939:Interferon
5927:IL29/IFNL1
4599:: 101610.
4290:2015-12-10
3868:: 114125.
3776:: 155351.
2417:1822/29592
1910:, May 2017
1889:, May 2017
1866:References
1692:mast cells
1576:, such as
1547:mast cells
1452:amino-acid
476:lymph node
434:(ortholog)
171:HomoloGene
7568:Unsorted:
7429:Agonists:
7408:Agonists:
7387:Agonists:
7347:Agonists:
7326:Agonists:
7270:Agonists:
7238:Agonists:
7197:Agonists:
7155:Agonists:
7127:Tadekinig
7109:Agonists:
7028:Agonists:
7002:Agonists:
6946:Agonists:
6905:Agonists:
6879:Agonists:
6853:Agonists:
6822:Agonists:
6781:Agonists:
6763:Levilimab
6753:Sirukumab
6743:Sarilumab
6700:Agonists:
6639:Agonists:
6616:Dupilumab
6583:Agonists:
6560:Muplestim
6537:Agonists:
6461:Agonists:
6388:Pifonakin
6383:Mobenakin
6366:Agonists:
6124:33/IL1F11
6089:1Ra/IL1F3
5736:IL6 like/
5453:CXCL8/IL8
5251:Chemokine
5243:By family
5236:cytokines
4915:: 54–69.
4558:(1): 22.
3890:249070122
3798:226218796
3754:205150174
2060:Structure
1828:PEGylated
1775:) cells.
1764:ligands.
1623:microRNAs
1611:autocrine
1531:monocytes
1483:IFN-alpha
1473:(Mda-7),
1448:homodimer
1317:NP_034678
1296:NP_000563
1270:NM_010548
1249:NM_000572
1079:Orthologs
179:GeneCards
7522:IL-22Rα1
7488:instead.
6805:instead.
6733:mAb 1339
6718:ARGX-109
6682:TPI ASM8
6652:YM-90709
6403:Anakinra
6398:AF-12198
6241:Monokine
5770:+non IL
5655:subunit)
5653:receptor
5624:TNFSF13B
5572:TNFC/LTB
5567:TNFB/LTA
4968:16375755
4939:28365213
4896:15780075
4861:15180472
4832:12791314
4803:12791313
4774:12791310
4745:12495723
4716:12220553
4687:46867122
4679:12207099
4650:11244051
4621:85495400
4613:30923023
4584:19298643
4529:10231374
4488:11717514
4404:11485736
4382:Immunity
4250:11788558
4198:10946310
4154:12374540
4113:10052405
4078:12672180
4011:11113067
3975:11113068
3939:16716759
3882:35644427
3847:33588074
3790:33127257
3770:Cytokine
3746:20714339
3701:21058811
3693:22189514
3655:18383040
3614:10320650
3524:44759539
3516:11192058
3481:23159957
3432:10972672
3424:17767162
3389:26309093
3354:22172723
3310:22581824
3266:25596108
3222:11568001
3181:36990295
3132:39224241
3124:10746547
2999:11500393
2950:15960096
2856:10898505
2812:40794643
2804:10973911
2659:11244051
2624:19307576
2565:21468030
2516:10861064
2475:16184516
2426:20154735
2378:22438968
2338:PLOS ONE
2319:32259074
2264:30195028
2215:20208540
2166:15032600
2131:26200010
2101:Immunity
2041:19161426
1989:30126106
1906:–
1885:–
1853:interact
1833:in vitro
1804:Knockout
1758:melanoma
1735:myokines
1633:Function
1625:such as
1491:type-III
1430:via the
1422:and two
1412:cytokine
1365:Wikidata
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