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1150:
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the tumour when the patient moves or if there is any movement of the tumour within the body. Therefore, the radiation sources remain accurately targeted. This enables clinicians to achieve a high level of dose conformity â i.e. ensuring the whole of the tumour receives an optimal level of radiation. It also reduces the risk of damage to healthy tissue, organs or structures around the tumour, thus enhancing the chance of cure and preservation of organ function.
203:
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through a series of connecting guide tubes. The treatment plan is sent to the afterloader, which then controls the delivery of the sources along the guide tubes into the pre-specified positions within the applicator. This process is only engaged once staff are removed from the treatment room. The sources remain in place for a pre-specified length of time, again following the treatment plan, following which they are returned along the tubes to the afterloader.
1108:
1464:, which allow the radiation to be delivered from a shielded safe, and the use of new radioactive sources in the 1950s and 1960s, reduced the risk of unnecessary radiation exposure to the operator and patients. This, together with more recent advancements in three-dimensional imaging modalities, computerised treatment planning systems and delivery equipment has made brachytherapy a safe and effective treatment for many types of cancer today.
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surgery, achieving the same probability of cure and with similar side effects. However, in locally advanced tumours, surgery may not routinely provide the best chance of cure and is often not technically feasible to perform. In these cases radiotherapy, including brachytherapy, offers the only chance of cure. In more advanced disease stages, brachytherapy can be used as palliative treatment for symptom relief from pain and bleeding.
543:, in which a catheter is placed inside blood vessels, through which sources are inserted and removed. In treating In-stent restenosis (ISR) Drug Eluting stents (DES) have been found to be superior to Intracoronary Brachytherapy (ICBT). However, there is continued interest in vascular brachytherapy for persistent restenosis in failed stents and vein grafts. The therapy has also been investigated for use in the treatment of
508:, provides an alternative treatment option to surgery. This is especially relevant for cancers on the nose, ears, eyelids or lips, where surgery may cause disfigurement or require extensive reconstruction. Various applicators can be used to ensure close contact between the radiation source(s) and the skin, which conform to the curvature of the skin and help ensure precision delivery of the optimal irradiation dose.
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procedures are performed on an outpatient basis. This convenience may be particularly relevant for patients who have to work, older patients, or patients who live some distance from treatment centres, to ensure that they have access to radiotherapy treatment and adhere to treatment plans. Shorter treatment times and outpatient procedures can also help improve the efficiency of radiotherapy clinics.
42:
7000:
7024:
400:
of a week. The option of brachytherapy may be particularly important in ensuring that working women, the elderly or women without easy access to a treatment centre, are able to benefit from breast-conserving therapy due to the short treatment course compared with WBI (which often requires more visits over the course of 1â2 months).
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during treatment, the radiation sources retain their correct position in relation to the tumour. These characteristics of brachytherapy provide advantages over EBRT â the tumour can be treated with very high doses of localised radiation whilst reducing the probability of unnecessary damage to surrounding healthy tissues.
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treated). As a precaution, some people receiving permanent brachytherapy may be advised to not hold any small children or be too close to pregnant women for a short time after treatment. Radiation oncologists or nurses can provide specific instructions to patients and advise for how long they need to be careful.
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distribution of the irradiation. This serves as a guide for the brachytherapy team to refine the distribution of the sources and provide a treatment plan that is optimally tailored to the anatomy of each patient before actual delivery of the irradiation begins. This approach is sometimes called 'dose-painting'.
1424:
Duane returned to the United States in 1913 and worked in a joint role as assistant professor of physics at
Harvard and Research Fellow in Physics of the Harvard Cancer Commission. The Cancer Commission was founded in 1901 and hired Duane to investigate the usage of radium emanations in the treatment
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solutions. Solutions containing 1 gram of radium were "milked" to create radon "seeds" of about 20 millicuries each. These "seeds" were distributed throughout Paris for use in an early form of brachytherapy named endocurietherapy. Duane perfected this "milking" technique during his time in Paris and
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Permanent brachytherapy, also known as seed implantation, involves placing small LDR radioactive seeds or pellets (about the size of a grain of rice) in the tumour or treatment site and leaving them there permanently to gradually decay. Over a period of weeks or months, the level of radiation emitted
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Permanent breast seed implantation (PBSI) implants many radioactive "seeds" (small pellets) into the breast in the area surrounding the site of the tumour, similar to permanent seed prostate brachytherapy. The seeds are implanted in a single 1â2 hour procedure and deliver radiation over the following
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The main benefit of breast brachytherapy compared to whole breast irradiation is that a high dose of radiation can be precisely applied to the tumour while sparing radiation to healthy breast tissues and underlying structures such as the ribs and lungs. APBI can typically be completed over the course
193:
The global market for brachytherapy reached US$ 680 million in 2013, of which the high-dose rate (HDR) and LDR segments accounted for 70%. Microspheres and electronic brachytherapy comprised the remaining 30%. One analysis predicts that the brachytherapy market may reach over US$ 2.4 billion in 2030,
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The images of the patient with the applicators in situ are imported into treatment planning software and the patient is brought into a dedicated shielded room for treatment. The treatment planning software enables multiple 2D images of the treatment site to be translated into a 3D 'virtual patient',
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To accurately plan the brachytherapy procedure, a thorough clinical examination is performed to understand the characteristics of the tumour. In addition, a range of imaging modalities can be used to visualise the shape and size of the tumour and its relation to surrounding tissues and organs. These
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Temporary brachytherapy involves placement of radiation sources for a set duration (usually a number of minutes or hours) before being withdrawn. The specific treatment duration will depend on many different factors, including the required rate of dose delivery and the type, size and location of the
605:
Brachytherapy for breast or skin cancer may cause scar tissue to form around the treatment area. In the case of breast brachytherapy, fat necrosis may occur as a result of fatty acids entering the breast tissues. This can cause the breast tissue to become swollen and tender. Fat necrosis is a benign
530:
Brachytherapy for skin cancer provides good cosmetic results and clinical efficacy; studies with up to five years follow-up have shown that brachytherapy is highly effective in terms of local control, and is comparable to EBRT. Treatment times are typically short, providing convenience for patients.
434:
Intracavitary breast brachytherapy (also known as "balloon brachytherapy") involves the placement of a single catheter into the breast cavity left after the removal of the tumour (lumpectomy). The catheter can be placed at the time of the lumpectomy or postoperatively. Via the catheter, a balloon is
395:
is usually performed with HDR temporary brachytherapy. Post surgery, breast brachytherapy can be used as a "boost" following whole breast irradiation (WBI) using EBRT. More recently, brachytherapy alone is used to deliver APBI (accelerated partial breast irradiation), involving delivery of radiation
329:
and is a standard of care in many countries. Cervical cancer can be treated with either LDR, PDR or HDR brachytherapy. Used in combination with EBRT, brachytherapy can provide better outcomes than EBRT alone. The precision of brachytherapy enables a high dose of targeted radiation to be delivered to
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A feature of brachytherapy is that the irradiation affects only a very localized area around the radiation sources. Exposure to radiation of healthy tissues farther away from the sources is therefore reduced. In addition, if the patient moves or if there is any movement of the tumour within the body
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Pistis F, Guedea F, Pera J, Gutierrez C, Ventura M, Polo A, Martinez E, Boladeras A, Ferrer F, Gabriele P, Linares L (2009). "External beam radiotherapy plus high-dose-rate brachytherapy for treatment of locally advanced prostate cancer: the initial experience of the
Catalan Institute of Oncology".
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Guedea F, Ferrer M, Pera J, AguilĂł F, Boladeras A, SuĂĄrez JF, Cunillera O, Ferrer F, Pardo Y, MartĂnez E, Ventura M (2009). "Quality of life two years after radical prostatectomy, prostate brachytherapy or external beam radiotherapy for clinically localised prostate cancer: The
Catalan Institute of
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Between 2003 and 2012 in United States community hospitals, the rate of hospital stays with brachytherapy (internal radiation therapy) had a 24.4 percent average annual decrease among adults aged 45â64 years and a 27.3 percent average annual decrease among adults aged 65â84 years. Brachytherapy was
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Using this information, a plan of the optimal distribution of the radiation sources can be developed. This includes consideration of how the source carriers (applicators), which are used to deliver the radiation to the treatment site, should be placed and positioned. Applicators are non-radioactive
403:
There are five methods that can be used to deliver breast brachytherapy: Interstitial breast brachytherapy, Intracavitary breast brachytherapy, Intraoperative radiation therapy, Permanent Breast Seed
Implantation and non-invasive breast brachytherapy using mammography for target localization and an
189:
A course of brachytherapy can be completed in less time than other radiotherapy techniques. This can help reduce the chance for surviving cancer-cells to divide and grow in the intervals between each radiotherapy dose. Patients typically have to make fewer visits to the radiotherapy clinic compared
2877:
Morris WJ, Keyes M, Palma D, McKenzie M, Spadinger I, Agranovich A, Pickles T, Liu M, Kwan W, Wu J, Lapointe V, Berthelet E, Pai H, Harrison R, Kwa W, Bucci J, Racz V, Woods R (2009). "Evaluation of
Dosimetric Parameters and Disease Response After 125Iodine Transperineal Brachytherapy for Low- and
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Imaging techniques, such as x-ray, fluoroscopy and ultrasound are typically used to help guide the placement of the applicators to their correct positions and to further refine the treatment plan. CAT scans and MRI can also be used. Once the applicators are inserted, they are held in place against
593:
Brachytherapy for prostate cancer may cause erectile dysfunction in approximately 15â30% of patients. However, the risk of erectile dysfunction is related to age (older men are at a greater risk than younger men) and also the level of erectile function prior to receiving brachytherapy. In patients
589:
In a small number of people, brachytherapy may cause long-term side effects due to damage or disruption of adjacent tissues or organs. Long-term side effects are usually mild or moderate in nature. For example, urinary and digestive problems may persist as a result of brachytherapy for cervical or
480:
radiation treatment, brachytherapy is one option for effective treatment, involves definitive radiotherapy (boost) or palliative treatments. Definitive radiotherapy (boost) can deliver the dose precisely and palliative treatments can be given to relieve dysphagia. The large diameter applicators or
412:
Interstitial breast brachytherapy involves the temporary placement of several flexible plastic catheters in the breast tissue. These are carefully positioned to allow optimal targeting of radiation to the treatment area while sparing the surrounding breast tissue. The catheters are connected to an
333:
The chances of staying free of disease (disease-free survival) and of staying alive (overall survival) are similar for LDR, PDR and HDR treatments. However, a key advantage of HDR treatment is that each dose can be delivered on an outpatient basis with a short administration time providing greater
304:
As the radiation sources can be precisely positioned at the tumour treatment site, brachytherapy enables a high dose of radiation to be applied to a small area. Furthermore, because the radiation sources are placed in or next to the target tumour, the sources maintain their position in relation to
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Remote afterloading systems provide protection from radiation exposure to healthcare professionals by securing the radiation source in a shielded safe. Once the applicators are correctly positioned in the patient, they are connected to an 'afterloader' machine (containing the radioactive sources)
614:
Patients often ask if they need to have special safety precautions around family and friends after receiving brachytherapy. If temporary brachytherapy is used, no radioactive sources remain in the body after treatment. Therefore, there is no radiation risk to friends or family from being in close
460:
Surgically
Targeted Radiation Therapy (STaRT), branded as GammaTile Therapy, is a type of brachytherapy implant specifically designed for use inside the brain. GammaTile is FDA-cleared to treat newly diagnosed, operable malignant intracranial neoplasms (i.e., brain tumors) and operable recurrent
374:
Temporary HDR brachytherapy is a newer approach to treating prostate cancer, but is currently less common than seed implantation. It is predominantly used to provide an extra dose in addition to EBRT (known as "boost" therapy) as it offers an alternative method to deliver a high dose of radiation
568:
Acute side effects associated with brachytherapy include localised bruising, swelling, bleeding, discharge or discomfort within the implanted region. These usually resolve within a few days following completion of treatment. Patients may also feel fatigued for a short period following treatment.
316:
In cases where the tumour is not easily accessible or is too large to ensure an optimal distribution of irradiation to the treatment area, brachytherapy can be combined with other treatments, such as EBRT and/or surgery. Combination therapy of brachytherapy exclusively with chemotherapy is rare.
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To identify the optimal spatial and temporal distribution of radiation sources within the applicators of the implanted tissue or cavity, the treatment planning software allows virtual radiation sources to be placed within the virtual patient. The software shows a graphical representation of the
181:
for instance) directly at the site of the cancerous tumour. These are enclosed in a protective capsule or wire, which allows the ionizing radiation to escape to treat and kill surrounding tissue but prevents the charge of radioisotope from moving or dissolving in body fluids. The capsule may be
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Galalae R, Martinez A, Mate T, Mitchell C, Edmundson G, Nuernberg N, Eulau S, Gustafson G, Gribble M, KovĂĄcs G (2004). "Long-term outcome by risk factors using conformal high-dose-rate brachytherapy (HDR-BT) boost with or without neoadjuvant androgen suppression for localized prostate cancer".
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If permanent brachytherapy is used, low dose radioactive sources (seeds) are left in the body after treatment â the radiation levels are very low and decrease over time. In addition, the irradiation only affects tissues within a few millimeters of the radioactive sources (i.e. the tumour being
576:
Brachytherapy for skin cancer may result in a shedding of the outer layers of skin (desquamation) around the area of treatment in the weeks following therapy, which typically heals in 5â8 weeks. If the cancer is located on the lip, ulceration may occur as a result of brachytherapy, but usually
572:
Brachytherapy treatment for cervical or prostate cancer can cause acute and transient urinary symptoms such as urinary retention, urinary incontinence or painful urination (dysuria). Transient increased bowel frequency, diarrhoea, constipation or minor rectal bleeding may also occur. Acute and
2629:
Pötter R, Haie-Meder C, Van
Limbergen EV, Barillot I, De Brabandere MD, Dimopoulos J, Dumas I, Erickson B, Lang S, Nulens A, Petrow P, Rownd J, Kirisits C, Gec Estro Working G (2006). "Recommendations from gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D image-based
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There are also devices that combine the features of interstitial and intracavitary breast brachytherapy (e.g. SAVI). These devices use multiple catheters but are inserted through a single-entry point in the breast. Studies suggest the use of multiple catheters enables physicians to target the
425:
Intraoperative radiation therapy (IORT) delivers radiation at the same time as the surgery to remove the tumour (lumpectomy). An applicator is placed in the cavity left after tumour removal and a mobile electronic device generates radiation (either x-rays or electrons) and delivers it via the
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Brachytherapy can be used with the aim of curing the cancer in cases of small or locally advanced tumours, provided the cancer has not metastasized (spread to other parts of the body). In appropriately selected cases, brachytherapy for primary tumours often represents a comparable approach to
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The use of HDR brachytherapy enables overall treatment times to be reduced compared with EBRT. Patients receiving brachytherapy generally have to make fewer visits for radiotherapy compared with EBRT, and overall radiotherapy treatment plans can be completed in less time. Many brachytherapy
2302:
Lertsanguansinchai P, Lertbutsayanukul C, Shotelersuk K, Khorprasert C, Rojpornpradit P, Chottetanaprasith T, Srisuthep A, Suriyapee S, Jumpangern C, Tresukosol D, Charoonsantikul C (2004). "Phase III randomized trial comparing LDR and HDR brachytherapy in treatment of cervical carcinoma".
580:
Most of the acute side effects associated with brachytherapy can be treated with medication or through dietary changes, and usually disappear over time (typically a matter of weeks), once the treatment is completed. The acute side effects of HDR brachytherapy are broadly similar to EBRT.
371:. The procedure can be completed quickly and patients are usually able to go home on the same day of treatment and return to normal activities after one to two days. Permanent seed implantation is often a less invasive treatment option compared to the surgical removal of the prostate.
3686:
Homs MY, Steyerberg EW, Eijkenboom WM, Tilanus HW, Stalpers LJ, Bartelsman JF, van
Lanschot JJ, Wijrdeman HK, Mulder CJ (October 2004). "Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial".
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subacute side effects usually resolve over a matter of days or a few weeks. In the case of permanent (seed) brachytherapy for prostate cancer, there is a small chance that some seeds may migrate out of the treatment region into the bladder or urethra and be passed in the urine.
2385:
Gaffney D, Du Bois A, Narayan K, Reed N, Toita T, Pignata S, Blake P, Portelance L, Sadoyze A, Pötter R, Colombo A, Randall M, Mirza MR, Trimble EL (2007). "Practice
Patterns of Radiotherapy in Cervical Cancer Among Member Groups of the Gynecologic Cancer Intergroup (GCIG)".
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Following initial interest in brachytherapy in Europe and the US, its use declined in the middle of the twentieth century due to the problem of radiation exposure to operators from the manual application of the radioactive sources. However, the development of
2955:
Frank S, Pisters L, Davis J, Lee A, Bassett R, Kuban D (2007). "An
Assessment of Quality of Life Following Radical Prostatectomy, High Dose External Beam Radiation Therapy and Brachytherapy Iodine Implantation as Monotherapies for Localized Prostate Cancer".
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Kim DH, Wang-Chesebro A., Weinberg V., Pouliot J., Chen LM, Speight J., Littell R., Hsu IC (2009). "HighâDose Rate Brachytherapy Using Inverse Planning Simulated Annealing for Locoregionally Advanced Cervical Cancer: A Clinical Report with 2-Year Follow-Up".
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Pulsed-dose rate (PDR) brachytherapy involves short pulses of radiation, typically once an hour, to simulate the overall rate and effectiveness of LDR treatment. Typical tumour sites treated by PDR brachytherapy are gynaecological and head and neck cancers.
1190:
In contrast, afterloading involves the accurate positioning of non-radioactive applicators in the treatment site, which are subsequently loaded with the radiation sources. In manual afterloading, the source is delivered into the applicator by the operator.
3650:
Fuccio L, Mandolesi D, Farioli A, Hassan C, Frazzoni L, Guido A, de Bortoli N, Cilla S, Pierantoni C (March 2017). "Brachytherapy for the palliation of dysphagia owing to esophageal cancer: A systematic review and meta-analysis of prospective studies".
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therapy that conforms to the shape of the tumour within the prostate, while sparing radiation exposure to surrounding tissues. HDR brachytherapy as a boost for prostate cancer also means that the EBRT course can be shorter than when EBRT is used alone.
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within which the position of the applicators can be defined. The spatial relationships between the applicators, the treatment site and the surrounding healthy tissues within this 'virtual patient' are a copy of the relationships in the actual patient.
358:
Permanent seed implantation is suitable for patients with a localised tumour and good prognosis and has been shown to be a highly effective treatment to prevent the cancer from returning. The survival rate is similar to that found with EBRT or surgery
4698:
Alex Rijnders. Photon Sources for Bracytherapy. pp 185-194 in Radiotherapy and Brachytherapy, Eds. Yves Lemoigne, Alessandra Caner. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer Science & Business Media, 2009
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Nelson JC, Beitsch PD, Vicini FA, Quiet CA, Garcia D, Snider HC, Gittleman MA, Zannis VJ, Whitworth PW, Fine RE, Keleher AJ, Kuerer HM (2009). "Four-year clinical update from the American Society of Breast Surgeons MammoSite brachytherapy trial".
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The brachytherapy market is expected to reach over US$ 2.4 billion in 2030, growing by 8% annually, mainly driven by the microspheres market as well as electronic brachytherapy, which is gaining significant interest worldwide as a user-friendly
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169:(radioisotope) is injected into the body to chemically localize to the tissue requiring destruction. It also contrasts to External Beam Radiation Therapy (EBRT), in which high-energy x-rays (or occasionally gamma-rays from a radioisotope like
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include x-ray radiography, ultrasound, computed axial tomography (CT or CAT) scans and magnetic resonance imaging (MRI). The data from many of these sources can be used to create a 3D visualisation of the tumour and the surrounding tissues.
4153:
Perez-castellano N, VillacastĂn J, Aragoncillo P, Fantidis P, SabatĂ© M, GarcĂa-Torrent MJ, Prieto C, Corral JM, Moreno J, FernĂĄndez-Ortiz A, Vano E, MacAya C (2006). "Pathological Effects of Pulmonary Vein beta-Radiation in a Swine Model".
3781:
Akagi Y, Hirokawa Y, Kagemoto M, Matsuura K, Ito A, Fujita K, Kenjo M, Kiriu H, Ito K (February 1999). "Optimum fractionation for high-dose-rate endoesophageal brachytherapy following external irradiation of early stage esophageal cancer".
1404:
also suggested the use of radiation in this way. In the early twentieth century, techniques for the application of brachytherapy were pioneered at the Curie institute in Paris by Danlos and at St Luke's and Memorial Hospital in New York by
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Members A/, Albertsson S, Avilés P, Camici FF, Colombo PG, Hamm A, JÞrgensen C, Marco E, Nordrehaug J, Ruzyllo W, Urban P, Stone GW, Wijns W, Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology (2005).
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Folkert MR, Cohen GN, Wu AJ, Gerdes H, Schattner MA, Markowitz AJ, Ludwig E, Ilson DH, Bains MS (September 2013). "Endoluminal high-dose-rate brachytherapy for early stage and recurrent esophageal cancer in medically inoperable patients".
190:
with EBRT, and may receive the treatment as outpatients. This makes treatment accessible and convenient for many patients. These features of brachytherapy mean that most patients are able to tolerate the brachytherapy procedure very well.
3033:
Hoskin PJ, Motohashi K, Bownes P, Bryant L, Ostler P (2007). "High dose rate brachytherapy in combination with external beam radiotherapy in the radical treatment of prostate cancer: initial results of a randomised phase three trial".
1198:
On completion of delivery of the radioactive sources, the applicators are carefully removed from the body. Patients typically recover quickly from the brachytherapy procedure, enabling it to often be performed on an outpatient basis.
1989:"Analysis of health related quality of life (HRQoL) of patients with clinically localized prostate cancer, one year after treatment with external beam radiotherapy (EBRT) alone versus EBRT and high dose rate brachytherapy (HDRBT)"
2513:
Haie-meder C, Chargari C, Rey A, Dumas I, Morice P, Magné N (2009). "DVH parameters and outcome for patients with early-stage cervical cancer treated with preoperative MRI-based low dose rate brachytherapy followed by surgery".
4391:"Three-year analysis of treatment efficacy, cosmesis, and toxicity by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI)"
527:. the radiation source is enclosed in a compound which is applied to a thin protective foil directly over the lesion. This way the radiation source can be applied to complex locations and minimize radiation to healthy tissue.
4625:
1128:
This initial planning helps to ensure that 'cold spots' (too little irradiation) and 'hot spots' (too much irradiation) are avoided during treatment, as these can respectively result in treatment failure and side-effects.
4004:
Rio E, Bardet E, Ferron C, Peuvrel P, Supiot S, Campion L, Beauvillain De Montreuil C, Mahe M, Dreno B (2005). "Interstitial brachytherapy of periorificial skin carcinomas of the face: A retrospective study of 97 cases".
1183:
The radiation sources used for brachytherapy are always enclosed within a non-radioactive capsule. The sources can be delivered manually, but are more commonly delivered through a technique known as 'afterloading'.
5775:
4296:
Magné N, Mancy NC, Chajon E, Duvillard P, Pautier P, Castaigne D, Lhommé C, Morice P, Haie-Meder C (2009). "Patterns of care and outcome in elderly cervical cancer patients: A special focus on brachytherapy".
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the skin using sutures or adhesive tape to prevent them from moving. Once the applicators are confirmed as being in the correct position, further imaging can be performed to guide detailed treatment planning.
1838:
The global market for brachytherapy reached US$ 680 million in 2013, of which the High-Dose Rate (HDR) and LDR segments accounted for 70%. Microspheres and electronic brachytherapy commanded the remaining
1720:
Pieters BR, De Back DZ, Koning CC, Zwinderman AH (2009). "Comparison of three radiotherapy modalities on biochemical control and overall survival for the treatment of prostate cancer: A systematic review".
559:
The likelihood and nature of potential acute, sub-acute or long-term side-effects associated with brachytherapy depends on the location of the tumour being treated and the type of brachytherapy being used.
748:
The calculation of radiation dose from radioactive seeds is crucial in the planning and administration of brachytherapy treatments. Most modern calculation are done using the formalism published by the
4562:
Nath R, Anderson LL, Luxton G, Weaver KA, Williamson JF, Meigooni AS (1995). "Dosimetry of interstitial brachytherapy sources: Recommendations of the AAPM Radiation Therapy Committee Task Group N. 43".
391:
surgery, and is an integral component of breast-conserving therapy. Brachytherapy can be used after surgery, before chemotherapy or palliatively in the case of advanced disease. Brachytherapy to treat
4201:
1877:
Mazeron JJ, Ardiet JM, Haie-MĂ©der C, KovĂĄcs GR, Levendag P, Peiffert D, Polo A, Rovirosa A, Strnad V (2009). "GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas".
3504:
1670:"Radical Prostatectomy, External Beam Radiotherapy, or External Beam Radiotherapy With Brachytherapy Boost and Disease Progression and Mortality in Patients with Gleason Score 9-10 Prostate Cancer"
1782:
696:
Low-dose rate (LDR) brachytherapy involves implanting radiation sources that emit radiation at a rate of up to 2 Gy·h. LDR brachytherapy is commonly used for cancers of the oral cavity,
3412:
Yashar C, Blair S, Wallace A, Scanderbeg D (2009). "Initial Clinical Experience with the Strut-Adjusted Volume Implant Brachytherapy Applicator for Accelerated Partial Breast Irradiation".
2217:
Litwin MS, Gore JL, Kwan L, Brandeis JM, Lee SP, Withers HR, Reiter RE (2007). "Quality of life after surgery, external beam irradiation, or brachytherapy for early-stage prostate cancer".
1912:
DvorĂĄk, JandĂk P, Melichar B, Jon B, MergancovĂĄ J, Zoul Z, Vacek Z, Petera J (2002). "Intraluminal high dose rate brachytherapy in the treatment of bile duct and gallbladder carcinomas".
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by the sources will decline to almost zero. The inactive seeds then remain in the treatment site with no lasting effect. Permanent brachytherapy is most commonly used in the treatment of
3730:
Nonoshita T, Sasaki T, Hirata H, Toh Y, Shioyama Y, Nakamura K, Honda H (2007-10-26). "High-dose-rate brachytherapy for previously irradiated patients with recurrent esophageal cancer".
2112:
Guedea F, Ventura M, Mazeron J, Torrecilla J, Bilbao P, BorrĂ s J (2008). "Patterns of Care for Brachytherapy in Europe: Facilities and resources in brachytherapy in the European area".
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194:
growing by 8% annually, mainly driven by the microspheres market as well as electronic brachytherapy, which is gaining significant interest worldwide as a user-friendly technology.
150:
and can also be used to treat tumours in many other body sites. Treatment results have demonstrated that the cancer-cure rates of brachytherapy are either comparable to surgery and
4656:
3531:"Surgically Targeted Radiation Therapy: Safety Profile of Collagen Tile Brachytherapy in 79 Recurrent, Previously Irradiated Intracranial Neoplasms on a Prospective Clinical Trial"
1125:
and are typically needles or plastic catheters. The specific type of applicator used will depend on the type of cancer being treated and the characteristics of the target tumour.
5963:
3909:
Guix, Finestres F, Tello J, Palma C, Martinez A, Guix J, Guix R (2000). "Treatment of skin carcinomas of the face by high-dose-rate brachytherapy and custom-made surface molds".
653:
Contact brachytherapy involves placement of the radiation source in a space next to the target tissue. This space may be a body cavity (intracavitary brachytherapy) such as the
1091:
cancer. In LDR and PDR brachytherapy, the source typically stays in place up to 24 hours before being removed, while in HDR brachytherapy this time is typically a few minutes.
5490:
3328:
Shah AP, Strauss JB, Kirk MC, Chen SS, Dickler A (2010). "A dosimetric analysis comparing electron beam with the MammoSite brachytherapy applicator for intact breast boost".
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897:
856:
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Doust, Miller E, Duchesne G, Kitchener M, Weller D (2004). "A systematic review of brachytherapy. Is it an effective and safe treatment for localised prostate cancer?".
154:(EBRT) or are improved when used in combination with these techniques. Brachytherapy can be used alone or in combination with other therapies such as surgery, EBRT and
6666:
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Sai H, Mitsumori M, Araki N, Mizowaki T, Nagata Y, Nishimura Y, Hiraoka M (August 2005). "Long-term results of definitive radiotherapy for stage I esophageal cancer".
815:
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Brachytherapy followed EBRT or surgery have been shown to improve the survival rate and local recurrent rate than EBRT or surgery only for esophageal cancer patients.
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Research shows locally advanced carcinoma of the cervix must be treated with a combination of external beam radiotherapy (EBRT) and intracavity brachytherapy (ICBT).
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789:
932:
713:
High-dose rate (HDR) brachytherapy is when the rate of dose delivery exceeds 12 Gy·h. The most common applications of HDR brachytherapy are in tumours of the
750:
452:
months as the radioactive material inside them decays. Risk of radiation from the implants to others (e.g. partner/spouse) has been studied and found to be safe.
5470:
1491:
Due to the small size of brachytherapy sources and low control in early decades, there is a risk that some of these have escaped into the environment to become
1137:
Before radioactive sources can be delivered to the tumour site, the applicators have to be inserted and correctly positioned in line with the initial planning.
439:, which delivers the radiation dose through the catheter and into the balloon. Currently, intracavitary breast brachytherapy is only routinely used for APBI.
7062:
5792:
5223:
4205:
3508:
2913:
Pickles T, Keyes M, Morris WJ (2009). "Brachytherapy or Conformal External Radiotherapy for Prostate Cancer: A Single-Institution Matched-Pair Analysis".
173:) are directed at the tumour from outside the body. Brachytherapy instead involves the precise placement of short-range radiation-sources (radioisotopes,
5558:
1786:
468:
In a clinical study, GammaTile Therapy improved local tumor control compared to previous same-site treatments without an increased risk of side effects.
7342:
6061:
689:
The dose rate of brachytherapy refers to the level or 'intensity' with which the radiation is delivered to the surrounding medium and is expressed in
650:
In the case of interstitial brachytherapy, the sources are placed directly in the target tissue of the affected site, such as the prostate or breast.
3612:
Hishikawa Y, Kurisu K, Taniguchi M, Kamikonya N, Miura T (October 1991). "High-dose-rate intraluminal brachytherapy (HDRIBT) for esophageal cancer".
2630:
treatment planning in cervix cancer brachytherapyâ3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology".
417:, which delivers the planned radiation dose to the treatment area. Interstitial breast brachytherapy can be used as "boost" after EBRT, or as APBI.
4765:
4073:"Guidelines for Percutaneous Coronary Interventions: the Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology"
78:
5169:
2478:
Viswanathan AN, Erickson BA (2009). "Three-Dimensional Imaging in Gynecologic Brachytherapy: A Survey of the American Brachytherapy Society".
7574:
5485:
3156:
2096:
1514:
7244:
6307:
6224:
4681:
6300:
5770:
5735:
2824:
Battermann J, Boon T, Moerland M (2004). "Results of permanent prostate brachytherapy, 13 years of experience at a single institution".
3945:
1400:
that a radioactive source could be inserted into a tumour. It was found that the radiation caused the tumour to shrink. Independently,
6922:
6506:
710:
Medium-dose rate (MDR) brachytherapy is characterized by a medium rate of dose delivery, ranging between 2 Gy·h to 12 Gy·h.
4043:
Musmacher J, et al. (2006). "High dose rate brachytherapy with surface applicators: Treatment for nonmelanomatous skin cancer".
1425:
of cancer. In 1915 he built Boston's first "radium cow" and thousands of patients were treated with the radon-222 generated from it.
7192:
5586:
5465:
4704:
4626:"New inverse planning technology for image-guided cervical cancer brachytherapy: Description and evaluation within a clinical frame"
3467:
3312:
3279:
7337:
7055:
6816:
6681:
5216:
1529:
2340:"Neoadjuvant interstitial high-dose-rate (HDR) brachytherapy combined with systemic chemotherapy in patients with breast cancer"
647:
The two main types of brachytherapy treatment in terms of the placement of the radioactive source are interstitial and contact.
7389:
6759:
6593:
6431:
6195:
6073:
5730:
5591:
7127:
6749:
6598:
6056:
60:
1187:
Manual delivery of brachytherapy is limited to a few LDR applications, due to risk of radiation exposure to clinical staff.
4833:
1852:
1833:
7384:
6523:
6356:
5780:
5708:
4902:
7028:
7514:
7268:
6866:
6603:
6312:
6066:
5563:
4389:
Vicini F, Beitsch PD, Quiet CA, Keleher AJ, Garcia D, Snider Jr HC, Gittleman MA, Zannis VJ, Kuerer HM, Lyden M (2008).
1519:
162:
7499:
7299:
7048:
7016:
6929:
6901:
6858:
6823:
6661:
6488:
6426:
6251:
6155:
6041:
5509:
5209:
544:
2767:
1456:
rose in prominence. First used in 1958, iridium is the most commonly used artificial source for brachytherapy today.
1203:
the OR procedure with the greatest change in occurrence among hospital stays paid by Medicare and private insurance.
485:
to expand the esophagus and facilitate the delivery of radiation dose to tumor with sparing of nearby normal tissue.
4431:
7584:
7090:
6709:
6388:
5906:
5863:
5715:
1504:
151:
6361:
740:
7419:
7004:
6686:
6295:
6078:
5060:
1413:
2453:
531:
It has been suggested that brachytherapy may become a standard of treatment for skin cancer in the near future.
7579:
7484:
7439:
6934:
6776:
6676:
6588:
5797:
5683:
5643:
5455:
3862:"Personalized irradiation therapy for NMSC by rhenium-188 skin cancer therapy: a long-term retrospective study"
85:
5147:
3483:
6555:
4609:
Flynn A, et al. (2005). "Isotopes and delivery systems for brachytherapy". In Hoskin P, Coyle C (eds.).
3072:
Pisansky TM, Gold DG, Furutani KM, MacDonald OK, McLaren RH, Mynderse LA, Wilson TM, Hebl JR, Choo R (2008).
594:
who do experience erectile dysfunction, the majority of cases can successfully be treated with drugs such as
6806:
6781:
6395:
6172:
5978:
5901:
5858:
5841:
5802:
5725:
677:. A radiation source can also be placed in blood vessels (intravascular brachytherapy) for the treatment of
524:
505:
202:
1412:
Working with the Curies in their radium research laboratory at the University of Paris, American physicist
7221:
6671:
5958:
5502:
2708:"High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer"
1509:
1495:. A radium needle was found in a Prague playground in 2011, radiating 500 ÎŒSv/h from one metre away.
1397:
346:
733:. Most HDR treatments are performed on an outpatient basis, but this is dependent on the treatment site.
7444:
6965:
6701:
6656:
6118:
6046:
5973:
5968:
5933:
5720:
5688:
5475:
5402:
4624:
Trnkovå P., Pötter R., Baltas D., Karabis A., Fidarova E., Dimopoulos J., Georg D., Kirisits C. (2009).
1401:
599:
360:
3860:
Cipriani C, Desantis M, Dahlhoff G, Brown SD, Wendler T, Olmeda M, Pietsch G, Eberlein B (2020-07-22).
3530:
1073:{\displaystyle D(r,\theta )=S_{k}\Lambda {\frac {G(r,\theta )}{G(r_{0},\theta _{0})}}g(r)F(r,\theta )t}
797:: How much dose the seed will deliver to the reference point over a certain period of time, denoted by
426:
applicator. Radiation is delivered all at once and the applicator removed before closing the incision.
4769:
4230:
Fieler (1997). "Side effects and quality of life in patients receiving high-dose rate brachytherapy".
2590:"Present status and future of high-precision image guided adaptive brachytherapy for cervix carcinoma"
511:
Another type of brachytherapy which has similar advantages as the HDR is provided be the Rhenium-SCT (
7504:
7494:
7469:
7319:
7187:
6876:
6850:
6651:
6636:
5953:
5911:
5747:
5653:
5581:
4940:
4878:
4572:
823:: How the shape of the seed will affect the dose at points away from the reference point, denoted by
520:
501:
368:
3946:"Dermatological high-dose-rate brachytherapy for the treatment of basal and squamous cell carcinoma"
1166:
7524:
7509:
7379:
7238:
7132:
7113:
6975:
6811:
6786:
6571:
6165:
6033:
5836:
5693:
5460:
5422:
5255:
3119:
3074:"High-dose-rate brachytherapy in the curative treatment of patients with localized prostate cancer"
2796:
1944:
Nag S. (2004). "High dose rate brachytherapy: its clinical applications and treatment guidelines".
548:
867:
826:
7429:
7314:
7118:
7108:
6955:
6691:
6528:
6455:
6266:
5916:
5886:
5870:
5853:
5497:
5387:
5335:
5285:
5232:
5041:
4544:
4179:
3986:
3763:
3712:
3550:
3202:
2367:
2242:
2199:
1969:
1761:
Stewart AJ, et al. (2007). "Radiobiological concepts for brachytherapy". In Devlin P (ed.).
1448:
needles were also used briefly after World War II. Radon and cobalt were replaced by radioactive
666:
482:
250:
3177:
PolgĂĄr C, Major T (2009). "Current status and perspectives of brachytherapy for breast cancer".
1149:
2667:"High-dose-rate versus low-dose-rate intracavitary therapy for carcinoma of the uterine cervix"
1107:
7519:
7479:
7071:
6023:
5816:
5703:
5678:
5616:
5573:
5417:
5412:
5407:
5250:
5102:
5033:
4998:
4956:
4894:
4814:
4707:
4700:
4648:
4588:
4536:
4412:
4371:
4314:
4273:
4239:
4171:
4135:
4094:
4022:
3978:
3926:
3891:
3883:
3842:
3834:
3799:
3755:
3747:
3704:
3668:
3629:
3594:
3586:
3463:
3429:
3394:
3345:
3308:
3275:
3241:
3194:
3152:
3095:
3051:
3012:
2973:
2930:
2895:
2841:
2745:
2727:
2688:
2647:
2611:
2567:
2531:
2495:
2403:
2359:
2320:
2281:
2234:
2191:
2129:
2092:
2069:
2020:
1961:
1921:
1894:
1738:
1699:
1630:
1534:
800:
477:
143:
115:
73:
4519:
Koukourakis G, et al. (2009). "Brachytherapy for prostate cancer: A systematic review".
3492:
606:
condition and typically occurs 4â12 months after treatment and affects about 2% of patients.
7182:
7163:
6871:
5926:
5891:
5648:
5638:
5526:
5514:
5355:
5350:
5340:
5330:
5325:
5094:
5025:
4990:
4948:
4886:
4804:
4735:
4640:
4580:
4528:
4430:
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health.
4402:
4363:
4306:
4163:
4125:
4084:
4052:
4014:
3968:
3960:
3918:
3873:
3826:
3791:
3739:
3696:
3660:
3621:
3578:
3542:
3455:
3421:
3384:
3376:
3337:
3300:
3267:
3262:
Vaidya JS (2009). "APBI with 50 kV Photons: Targeted Intraoperative Radiotherapy (TARGIT)".
3233:
3186:
3085:
3043:
3004:
2965:
2922:
2887:
2833:
2735:
2719:
2678:
2639:
2601:
2559:
2523:
2487:
2395:
2351:
2312:
2273:
2226:
2183:
2121:
2059:
2051:
2010:
2000:
1953:
1886:
1730:
1689:
1681:
1524:
1273:
1246:
1237:
6511:
6351:
6290:
3295:
Orecchia R, Ivaldi GB, Leonardi MC (2009). "APBI Intraoperative Technique with Electrons".
2588:
Potter R, Kirisits C, Fidarova E, Dimopoulos J, Berger D, Tanderup K, Lindegaard J (2008).
2148:
767:
7489:
7394:
6839:
6769:
6729:
6256:
6183:
6011:
5997:
5921:
5896:
5742:
5535:
5427:
5392:
5270:
5260:
1492:
1389:
1096:
908:
761:
705:
355:
can be given either as permanent LDR seed implantation or as temporary HDR brachytherapy.
352:
326:
135:
131:
6261:
4994:
4944:
4882:
4576:
7374:
7197:
7144:
6744:
6724:
6719:
6714:
6464:
6371:
6340:
6322:
5846:
5752:
5698:
5663:
5596:
5543:
5397:
5290:
5275:
5265:
4929:"William Duane and the radium cow: An American contribution to the emerging atomic age"
4056:
3389:
3364:
2740:
2707:
2064:
2039:
2015:
1988:
1694:
1669:
1417:
678:
598:. Importantly, the risk of erectile dysfunction after brachytherapy is less than after
540:
238:
127:
5016:
Winston P (June 1958). "Carcinoma of the Trachea Treated by Radon Seed Implantation".
3922:
3795:
3700:
7568:
7474:
7231:
6909:
6200:
5447:
5085:
Aronowitz J (2008). "The "Golden Age" of prostate brachytherapy: A cautionary tale".
4167:
3964:
3625:
3554:
2055:
1468:
1349:
1332:
1087:
The placement of radiation sources in the target area can be temporary or permanent.
905:: How the radiation will interact with the material surrounding the seed, denoted by
392:
139:
5045:
4548:
4183:
3990:
3716:
3206:
2371:
2246:
2203:
1973:
1653:
Viswanathan AN, et al. (2007). "Gynecologic brachytherapy". In Devlin P (ed.).
864:: How the much radiation will be stopped before passing out of the seed, denoted by
7550:
7464:
7434:
7309:
7303:
7123:
6475:
5611:
5553:
5480:
5432:
5302:
4809:
4792:
4354:
Moule RN, Hoskin PJ (2009). "Non-surgical treatment of localised prostate cancer".
3767:
3147:
Hoskin P, et al. (2005). "Breast Brachytherapy". In Hoskin P, Coyle C (eds.).
2723:
1393:
462:
461:
intracranial neoplasms, including meningiomas, metastases, high-grade gliomas, and
262:
166:
155:
4981:
Goldstein N (1975). "Radon seed implants. Residual radioactivity after 33 years".
3878:
3861:
3237:
1388:
Brachytherapy dates back to 1901 (shortly after the discovery of radioactivity by
182:
removed later, or (with some radioisotopes) it may be allowed to remain in place.
41:
17:
5098:
4644:
4367:
4310:
4018:
3830:
3664:
3582:
3546:
3459:
3425:
3304:
3271:
3047:
3008:
2926:
2891:
2837:
2643:
2563:
2527:
2491:
2399:
2316:
2277:
2125:
1890:
1734:
91:
55:
internal radiotherapy, sealed source radiotherapy, curietherapy, endocurietherapy
7354:
7252:
7248:
7137:
6886:
6533:
6123:
5630:
5601:
4682:"Most Frequent Operating Room Procedures Performed in U.S. Hospitals, 2003-2012"
2665:
Hareyama M, Sakata KI, Oouchi A, Nagakura H, Shido M, Someya M, Koito K (2002).
2040:"Treatment decisions for localized prostate cancer: asking men what's important"
1406:
1372:
1298:
1254:
1231:
690:
512:
497:
330:
the cervix, while minimising radiation exposure to adjacent tissues and organs.
242:
230:
178:
147:
4532:
4089:
4072:
3341:
2969:
1957:
7424:
7294:
7288:
7284:
7256:
7226:
5029:
3743:
3190:
2606:
2589:
2355:
2187:
1366:
1315:
1260:
697:
670:
388:
384:
258:
246:
174:
65:
3887:
3838:
3751:
3590:
3380:
2731:
325:
Brachytherapy is commonly used in the treatment of early or locally confined
7454:
7449:
6881:
6244:
6234:
5362:
5315:
5280:
4864:"The origins of Medical Physics in the USA: William Duane, Ph.D., 1913-1920"
4740:
4723:
4130:
4113:
1634:
1629:. Leuven, Belgium: European Society for Therapeutic Radiology and Oncology.
1441:
1428:
Interstitial radium therapy was common in the 1930s. Gold seeds filled with
1281:
1264:
718:
364:
266:
234:
170:
119:
6739:
5106:
5037:
4818:
4652:
4481:
Giap H, Tripuraneni P (2007). "Vascular brachytherapy". In Devlin P (ed.).
4416:
4375:
4318:
4277:
4175:
4139:
4098:
4026:
3982:
3930:
3895:
3846:
3803:
3759:
3708:
3672:
3598:
3433:
3398:
3349:
3245:
3198:
3099:
3055:
3016:
2977:
2934:
2899:
2862:
Ash D, et al. (2005). "Prostate Cancer". In Hoskin P, Coyle C (eds.).
2845:
2749:
2692:
2651:
2615:
2571:
2535:
2499:
2407:
2363:
2324:
2285:
2238:
2195:
2133:
2073:
2024:
2005:
1987:
Joseph KJ, Alvi R, Skarsgard D, Tonita J, Pervez N, Small C, Tai P (2008).
1965:
1925:
1898:
1742:
1703:
1685:
1211:
Commonly used radiation sources (radionuclides) for brachytherapy include:
5002:
4960:
4898:
4592:
4540:
4455:
4243:
3633:
3529:
Brachman D, Youssef E, Dardis C, Smith K, Pinnaduwage D, Nakaji P (2019).
1817:
Kelley JR, et al. (2007). "Breast brachytherapy". In Devlin P (ed.).
1625:
Gerbaulet A, Pötter R, Mazeron JJ, Meertens H, Limbergen EV, eds. (2002).
7459:
7155:
6970:
6764:
6613:
6608:
6548:
6217:
6145:
6128:
6113:
6088:
5831:
5320:
5196:
2454:"American Brachytherapy Society cervical cancer brachytherapy task group"
1449:
1437:
730:
701:
215:
130:
for short. Brachytherapy is commonly used as an effective treatment for
7414:
6939:
6891:
6754:
6734:
6133:
6108:
5548:
5437:
5379:
5367:
5345:
5310:
4407:
4390:
3090:
3073:
2683:
2666:
2230:
1453:
726:
516:
282:
278:
254:
3973:
2706:
Liu R, Wang X, Tian JH, Yang K, Wang J, Jiang L, Hao XY (2014-10-09).
753:. For the geometry in figure 1, this formalism uses five parameters.
101:
7347:
7174:
7100:
7040:
6543:
6538:
6518:
6498:
6483:
6366:
6103:
6083:
6051:
5201:
5121:""Radioactive" little cylinder found underground in a park in PodolĂ"
4952:
4890:
4584:
1445:
714:
662:
658:
654:
627:
Different types of brachytherapy can be defined according to (1) the
595:
294:
290:
270:
219:
211:
5170:"Passerby stumbles upon radioactive playground thanks to wristwatch"
2424:
National Institute for Health and Clinical Excellence (March 2006).
6093:
4928:
2797:"American Brachytherapy Society prostate high-dose rate task group"
1153:
Creation of a virtual patient to plan the delivery of brachytherapy
383:
Radiation therapy is standard of care for women who have undergone
6960:
6917:
6580:
6436:
6239:
6229:
2768:"American Brachytherapy Society prostate low-dose rate task group"
1429:
1165:
1148:
1106:
739:
722:
435:
then inflated in the cavity. The catheter is then connected to an
298:
286:
229:
Brachytherapy can also be used in the treatment of tumours of the
201:
46:
Arrow points to brachytherapy beads used to treat prostate cancer.
4688:(186). Rockville, MD: Agency for Healthcare Research and Quality.
3365:"Evaluation of Three APBI Techniques under NSABP B-39 Guidelines"
1170:
Refinement of the treatment plan during a brachytherapy procedure
6441:
6330:
6140:
6098:
3120:"American Brachytherapy Society breast brachytherapy task group"
2425:
2339:
1433:
760:: How much radiation is being emitted by the seed, expressed as
674:
274:
223:
7044:
6836:
6008:
5995:
5205:
3450:
Pignol JP, Keller BM (2009). "Permanent Breast Seed Implants".
6414:
6278:
4332:
Casino AR, et al. (2006). "Brachytherapy in lip cancer".
396:
to only the immediate region surrounding the original tumour.
4803:. National Institute of Standards & Technology: 280â284.
4007:
International Journal of Radiation Oncology, Biology, Physics
3944:
Sedda AF, Rossi G, Cipriani C, Carrozzo AM, Donati P (2008).
3911:
International Journal of Radiation Oncology, Biology, Physics
3819:
International Journal of Radiation Oncology, Biology, Physics
3784:
International Journal of Radiation Oncology, Biology, Physics
3614:
International Journal of Radiation Oncology, Biology, Physics
2997:
International Journal of Radiation Oncology, Biology, Physics
2915:
International Journal of Radiation Oncology, Biology, Physics
2880:
International Journal of Radiation Oncology, Biology, Physics
2552:
International Journal of Radiation Oncology, Biology, Physics
2480:
International Journal of Radiation Oncology, Biology, Physics
2388:
International Journal of Radiation Oncology, Biology, Physics
2305:
International Journal of Radiation Oncology, Biology, Physics
2149:"Technological evolution in the treatment of prostate cancer"
206:
Body sites in which brachytherapy can be used to treat cancer
3363:
Scanderbeg D, Yashar C, White G, Rice R, Pawlicki T (2010).
5148:"Why a small cylinder buried in Prague radiates 500 ÎŒSv/h?"
4680:
Fingar KR, Stocks C, Weiss AJ, Steiner CA (December 2014).
4195:
4193:
2426:"High dose rate brachytherapy for carcinoma of the cervix"
2297:
2295:
1436:
shells were selected by Gino Failla around 1920 to shield
122:
is placed inside or next to the area requiring treatment.
1853:"Brachytherapy Market Recovery to Reach US$ 2.4 Billion"
1834:"Brachytherapy Market Recovery to Reach US$ 2.4 Billion"
1783:"Prostate cancer: internal radiotherapy (brachytherapy)"
665:; a body lumen (intraluminal brachytherapy) such as the
210:
Brachytherapy is commonly used to treat cancers of the
1416:
refined a technique for extracting radon-222 gas from
944:
911:
870:
829:
803:
770:
590:
prostate cancer, and may require ongoing management.
7543: Also known as sealed-source radiation therapy.
673:; or externally (surface brachytherapy) such as the
515:
Therapy). It makes use of the beta ray emissions of
7403:
7367:
7330:
7266:
7212:
7172:
7153:
7098:
7089:
7078:
6948:
6900:
6857:
6799:
6700:
6630:
6579:
6570:
6497:
6463:
6454:
6413:
6406:
6386:
6339:
6321:
6277:
6182:
6164:
6032:
5946:
5879:
5824:
5815:
5763:
5671:
5662:
5629:
5572:
5534:
5525:
5446:
5378:
5301:
5243:
4514:
4512:
1478:
84:
72:
59:
51:
34:
5964:Blue Ribbon Commission on America's Nuclear Future
3505:"2019 AANS Annual Scientific Meeting in San Diego"
3454:. Springer, Berlin, Heidelberg. pp. 263â276.
3299:. Springer, Berlin, Heidelberg. pp. 345â366.
3266:. Springer, Berlin, Heidelberg. pp. 327â344.
2447:
2445:
2443:
1648:
1646:
1644:
1072:
926:
891:
850:
809:
783:
4496:
4494:
4492:
4038:
4036:
3645:
3643:
2819:
2817:
4834:"Biographical Memoir of William Duane 1872-1935"
4450:
4448:
3067:
3065:
1668:Kishan A, Cook R, Ciezki J, et al. (2018).
1432:were used as early as 1942 until at least 1958.
7537: Also known as external-beam radiotherapy.
4793:"150th Anniversary of the Birth of Marie Curie"
2989:
2987:
2258:
2256:
1872:
1870:
1868:
1866:
1776:
1774:
1772:
1715:
1713:
4225:
4223:
3218:
3216:
3172:
3170:
3168:
3142:
3140:
3028:
3026:
2761:
2759:
2583:
2581:
2419:
2417:
2168:
2166:
1756:
1754:
1752:
938:The equation which links these parameters is,
751:American Association of Physicists in Medicine
636:
539:Brachytherapy can be used in the treatment of
7056:
6667:Small sealed transportable autonomous (SSTAR)
5217:
4717:
4715:
4604:
4602:
4349:
4347:
4291:
4289:
4287:
4259:
4257:
4255:
4253:
3113:
3111:
3109:
2950:
2948:
2946:
2944:
1812:
1810:
1808:
1806:
1804:
8:
1620:
1618:
1616:
1614:
1612:
1610:
1608:
1606:
1604:
1602:
1600:
1598:
1596:
1594:
1592:
1590:
1588:
1586:
1584:
1582:
1580:
1578:
1576:
1574:
1572:
1570:
4759:
4757:
4755:
4753:
4751:
4156:Journal of Cardiovascular Electrophysiology
3484:"GammaTile - Isoray Medical Inc. - K180515"
3369:Journal of Applied Clinical Medical Physics
2857:
2855:
1946:Technology in Cancer Research and Treatment
1939:
1937:
1935:
1568:
1566:
1564:
1562:
1560:
1558:
1556:
1554:
1552:
1550:
1472:
1111:Typical stages of a brachytherapy procedure
633:rate or 'intensity' of the irradiation dose
7095:
7086:
7063:
7049:
7041:
6833:
6644:
6576:
6460:
6410:
6403:
6179:
6005:
5992:
5821:
5668:
5531:
5240:
5224:
5210:
5202:
5065:ORAU Museum of Radiation and Radioactivity
4724:"Brachytherapy â past, present and future"
4483:Brachytherapy. Applications and Techniques
3179:International Journal of Clinical Oncology
2790:
2788:
1819:Brachytherapy. Applications and Techniques
1763:Brachytherapy. Applications and Techniques
1655:Brachytherapy: Applications and Techniques
1421:referred to the device as a "radium cow".
40:
4808:
4739:
4462:. American Society for Radiation Oncology
4406:
4129:
4088:
3972:
3877:
3388:
3089:
2739:
2682:
2605:
2174:Oncology/Bellvitge Hospital experience".
2063:
2014:
2004:
1693:
1025:
1012:
979:
970:
943:
910:
869:
828:
802:
775:
769:
5018:The Journal of Laryngology & Otology
4112:Sidawy, Weiswasser J, Waksman R (2002).
1537:(also called "electronic brachytherapy")
1467:The word "brachytherapy" comes from the
1213:
481:balloon type catheter are used with the
4611:Radiotherapy in practice: brachytherapy
3149:Radiotherapy in practice: brachytherapy
2864:Radiotherpay in practice: brachytherapy
2712:Cochrane Database of Systematic Reviews
2089:Radiotherapy in practice: brachytherapy
1627:The GEC ESTRO handbook of brachytherapy
1546:
1483:, meaning "short-distance" or "short".
1461:
363:), but with fewer side effects such as
6594:Liquid-fluoride thorium reactor (LFTR)
3452:Accelerated Partial Breast Irradiation
3297:Accelerated Partial Breast Irradiation
3264:Accelerated Partial Breast Irradiation
631:in the target treatment area, (2) the
496:HDR brachytherapy for nonmelanomatous
31:
6599:Molten-Salt Reactor Experiment (MSRE)
3953:Clinical and Experimental Dermatology
3445:
3443:
3257:
3255:
3151:. New York: Oxford University Press.
3118:Keisch, et al. (February 2007).
2176:Clinical & Translational Oncology
2091:. New York: Oxford University Press.
1515:Targeted intra-operative radiotherapy
635:delivered to the tumour, and (3) the
628:
7:
7245:Selective internal radiation therapy
7023:
5197:American Brachytherapy Society (ABS)
4995:10.1001/archderm.1975.01630180085013
4613:. New York: Oxford University Press.
2878:Intermediate-Risk Prostate Cancer".
2866:. New York: Oxford University Press.
2044:Journal of General Internal Medicine
547:and considered for the treatment of
6604:Integral Molten Salt Reactor (IMSR)
5059:Oak Ridge Associated Universities.
4114:"Peripheral vascular brachytherapy"
3866:Journal of Dermatological Treatment
97:
5564:Positron-emission tomography (PET)
4766:"A brief history of brachytherapy"
4501:Thomadsen BR, et al. (2005).
4057:10.1200/jco.2006.24.18_suppl.15543
976:
804:
629:placement of the radiation sources
447:Permanent breast seed implantation
430:Intracavitary breast brachytherapy
25:
5587:Neutron capture therapy of cancer
5486:Radioisotope thermoelectric (RTG)
2338:Roddiger SJ, et al. (2006).
408:Interstitial breast brachytherapy
7338:Intraoperative radiation therapy
7022:
7011:
7010:
6998:
6687:Fast Breeder Test Reactor (FBTR)
4456:"Treatment Types: Brachytherapy"
4168:10.1111/j.1540-8167.2006.00462.x
3965:10.1111/j.1365-2230.2008.02852.x
3125:. American Brachytherapy Society
2802:. American Brachytherapy Society
2773:. American Brachytherapy Society
2459:. American Brachytherapy Society
2087:Hoskin P, Coyle C, eds. (2005).
2056:10.1046/j.1525-1497.2000.90842.x
1785:. Guardian.co.uk. Archived from
1530:Intraoperative radiation therapy
421:Intraoperative radiation therapy
5776:Historical stockpiles and tests
3226:The American Journal of Surgery
1162:Optimizing the irradiation plan
545:peripheral vasculature stenosis
334:convenience for many patients.
7128:Stereotactic radiation therapy
6677:Energy Multiplier Module (EM2)
5559:Single-photon emission (SPECT)
5168:Falvey C (29 September 2011).
4843:. National Academy of Sciences
4810:10.1016/j.apradiso.2017.10.028
4797:Applied Radiation and Isotopes
2724:10.1002/14651858.cd007563.pub3
2147:Quang TS, et al. (2007).
1064:
1052:
1046:
1040:
1031:
1005:
997:
985:
960:
948:
921:
915:
886:
874:
845:
833:
632:
436:
414:
289:), female reproductive tract (
1:
7549: Also known as systemic
7385:Radiation-induced lung injury
7005:Nuclear technology portal
4505:. Medical Physics Publishing.
3923:10.1016/S0360-3016(99)00547-7
3879:10.1080/09546634.2020.1793890
3796:10.1016/S0360-3016(98)00433-7
3701:10.1016/S0140-6736(04)17272-3
3488:510(k) Premarket Notification
3238:10.1016/j.amjsurg.2008.09.016
1145:Creation of a virtual patient
237:, head and neck region (lip,
161:Brachytherapy contrasts with
7575:Radiation therapy procedures
7515:Radiation treatment planning
6867:Field-reversed configuration
6477:Uranium Naturel Graphite Gaz
5099:10.1016/j.brachy.2007.12.004
4645:10.1016/j.radonc.2009.10.004
4368:10.1016/j.suronc.2009.03.006
4311:10.1016/j.radonc.2008.08.011
4045:Journal of Clinical Oncology
4019:10.1016/j.ijrobp.2005.03.027
3831:10.1016/j.ijrobp.2004.12.042
3665:10.1016/j.radonc.2016.12.034
3626:10.1016/0360-3016(91)90267-8
3583:10.1016/j.brachy.2012.12.001
3547:10.1016/j.brachy.2019.04.076
3460:10.1007/978-3-540-88006-6_15
3426:10.1016/j.brachy.2009.03.190
3305:10.1007/978-3-540-88006-6_20
3272:10.1007/978-3-540-88006-6_19
3048:10.1016/j.radonc.2007.04.011
3009:10.1016/j.ijrobp.2003.08.003
2927:10.1016/j.ijrobp.2009.01.081
2892:10.1016/j.ijrobp.2008.07.042
2838:10.1016/j.radonc.2004.01.020
2644:10.1016/j.radonc.2005.11.014
2564:10.1016/j.ijrobp.2009.01.002
2528:10.1016/j.radonc.2009.05.004
2492:10.1016/j.ijrobp.2009.01.043
2452:Viswanathan AN, et al.
2400:10.1016/j.ijrobp.2006.12.013
2317:10.1016/j.ijrobp.2004.01.034
2278:10.1016/j.brachy.2009.05.001
2126:10.1016/j.brachy.2008.03.001
1891:10.1016/j.radonc.2009.01.005
1735:10.1016/j.radonc.2009.08.033
1520:Unsealed source radiotherapy
892:{\displaystyle F(r,\theta )}
851:{\displaystyle G(r,\theta )}
679:coronary in-stent restenosis
541:coronary in-stent restenosis
163:unsealed source radiotherapy
7500:Percentage depth dose curve
6824:Aircraft Reactor Experiment
5771:States with nuclear weapons
5061:"Seeds (ca. 1940s - 1960s)"
4266:Australian Family Physician
4118:Journal of Vascular Surgery
2038:Holmboe, Concato J (2000).
1535:Contact X-ray brachytherapy
1479:
1462:remote afterloading systems
7601:
6662:Liquid-metal-cooled (LMFR)
5786:Tests in the United States
4927:Brucer M (November 1993).
4728:Journal of Medical Physics
4533:10.1177/000456328902600109
4200:Macmillan Cancer Support.
3342:10.1016/j.ejmp.2009.08.004
2970:10.1016/j.juro.2007.01.134
1958:10.1177/153303460400300305
1505:External beam radiotherapy
577:resolves after 4â6 weeks.
443:radiation more precisely.
344:
152:external beam radiotherapy
7533:
7525:Tissue to Air Ratio (TAR)
6992:
6847:
6787:Stable Salt Reactor (SSR)
6682:Reduced-moderation (RMWR)
6647:
6489:Advanced gas-cooled (AGR)
6019:
6004:
5991:
5239:
5030:10.1017/S0022215100054232
4633:Radiotherapy and Oncology
4299:Radiotherapy and Oncology
3744:10.1007/s11604-007-0152-4
3653:Radiotherapy and Oncology
3191:10.1007/s10147-008-0867-y
3036:Radiotherapy and Oncology
2826:Radiotherapy and Oncology
2632:Radiotherapy and Oncology
2607:10.1080/02841860802282794
2516:Radiotherapy and Oncology
2356:10.1007/s00066-006-1454-7
2188:10.1007/s12094-009-0387-x
1879:Radiotherapy and Oncology
1723:Radiotherapy and Oncology
1473:
1083:Duration of dose delivery
744:Dose calculation geometry
637:duration of dose delivery
165:, in which a therapeutic
98:
39:
27:Type of radiation therapy
7485:Oxygen enhancement ratio
7440:Dose verification system
6692:Dual fluid reactor (DFR)
6308:Steam-generating (SGHWR)
5644:Electron-beam processing
4090:10.1093/eurheartj/ehi138
3381:10.1120/jacmp.v11i1.3021
2766:Merrick GS, et al.
1327:27.4, 31.4 and 35.5 keV
810:{\displaystyle \Lambda }
525:squamous cell carcinomas
6807:Organic nuclear reactor
5979:Nuclear power phase-out
5902:Nuclear decommissioning
5842:Reactor-grade plutonium
5592:Targeted alpha-particle
5471:Accidents and incidents
4983:Archives of Dermatology
4741:10.4103/0971-6203.50045
4131:10.1067/mva.2002.123751
3490:. FDA. 23 January 2020.
3078:Mayo Clinic Proceedings
1914:Hepato-gastroenterology
1781:BMJ Group (June 2009).
795:Dose rate of the source
506:squamous cell carcinoma
351:Brachytherapy to treat
4686:HCUP Statistical Brief
4432:"Breast brachytherapy"
4232:Oncology Nursing Forum
4077:European Heart Journal
2958:The Journal of Urology
2006:10.1186/1748-717X-3-20
1686:10.1001/jama.2018.0587
1510:Prostate brachytherapy
1398:Henri-Alexandre Danlos
1293:1.17, 1.33 MeV Îł-rays
1171:
1154:
1112:
1074:
928:
893:
852:
811:
785:
758:Strength of the source
745:
347:Prostate brachytherapy
249:), respiratory tract (
207:
7445:Dose-volume histogram
5969:Anti-nuclear movement
4503:Brachytherapy Physics
2795:Hsu I-C, et al.
1402:Alexander Graham Bell
1169:
1152:
1110:
1075:
929:
894:
853:
812:
786:
784:{\displaystyle S_{k}}
743:
615:proximity with them.
600:radical prostatectomy
361:radical prostatectomy
301:), and soft tissues.
205:
7505:Radiation oncologist
7495:Pencil-beam scanning
7470:Multileaf collimator
7320:ibritumomab tiuxetan
6877:Reversed field pinch
6672:Traveling-wave (TWR)
6156:Supercritical (SCWR)
5654:Gemstone irradiation
4485:. Philadelphia: LWW.
1821:. Philadelphia: LWW.
1765:. Philadelphia: LWW.
1657:. Philadelphia: LWW.
1487:Environmental hazard
942:
927:{\displaystyle g(r)}
909:
903:Radial dose function
868:
827:
801:
768:
610:Safety around others
502:basal cell carcinoma
257:), digestive tract (
7510:Radiation Therapist
7380:Radiation proctitis
7239:Plaque radiotherapy
7114:Orthovoltage X-rays
6042:Aqueous homogeneous
5837:Reprocessed uranium
5510:Safety and security
5127:. 29 September 2011
4945:1993MedPh..20.1601B
4883:1993MedPh..20.1607W
4862:Webster EW (1993).
4791:Coursey BM (2017).
4772:on 22 December 2017
4577:1995MedPh..22..209N
4051:(18_suppl): 15543.
3695:(9444): 1497â1504.
862:Anisotropy function
549:atrial fibrillation
7545:
7539:
7315:Radioimmunotherapy
7119:Megavoltage X-rays
7109:Superficial X-rays
7072:Radiation oncology
6956:Dense plasma focus
5871:Actinide chemistry
5336:Isotope separation
5233:Nuclear technology
4722:Gupta VK. (1995).
4408:10.1002/cncr.23227
4208:on October 3, 2009
3732:Radiation Medicine
3091:10.4065/83.12.1364
2684:10.1002/cncr.10207
2344:Strahlenther Onkol
2231:10.1002/cncr.22676
1993:Radiation Oncology
1179:Treatment delivery
1172:
1155:
1113:
1070:
924:
889:
848:
807:
781:
762:air kerma strength
746:
277:), urinary tract (
208:
18:Internal radiation
7585:Cancer treatments
7560:
7559:
7520:Radiopharmacology
7480:Neutron generator
7363:
7362:
7208:
7207:
7038:
7037:
6988:
6987:
6984:
6983:
6935:Magnetized-target
6832:
6831:
6795:
6794:
6626:
6625:
6622:
6621:
6566:
6565:
6450:
6449:
6382:
6381:
5987:
5986:
5942:
5941:
5811:
5810:
5798:Weapon-free zones
5625:
5624:
5617:Radiopharmacology
4841:www.nasonline.org
4356:Surgical Oncology
3158:978-0-19-852940-8
3084:(12): 1364â1372.
2225:(11): 2239â2247.
2098:978-0-19-852940-8
1452:and gold, before
1381:
1380:
1207:Radiation sources
1035:
693:per hour (Gy/h).
478:esophageal cancer
472:Esophageal cancer
116:radiation therapy
109:
108:
16:(Redirected from
7592:
7546:
7540:
7390:Bystander effect
7277:
7276:
7183:Particle therapy
7164:Electron therapy
7096:
7087:
7065:
7058:
7051:
7042:
7026:
7025:
7014:
7013:
7003:
7002:
7001:
6913:
6872:Levitated dipole
6842:
6834:
6782:Helium gas (GFR)
6645:
6640:
6577:
6461:
6411:
6404:
6399:
6398:
6180:
6176:
6175:
6014:
6006:
5998:Nuclear reactors
5993:
5892:High-level (HLW)
5822:
5669:
5649:Food irradiation
5639:Atomic gardening
5532:
5515:Nuclear meltdown
5341:Nuclear material
5331:Fissile material
5326:Fertile material
5241:
5226:
5219:
5212:
5203:
5185:
5184:
5182:
5180:
5165:
5159:
5158:
5156:
5154:
5143:
5137:
5136:
5134:
5132:
5117:
5111:
5110:
5082:
5076:
5075:
5073:
5071:
5056:
5050:
5049:
5013:
5007:
5006:
4978:
4972:
4971:
4969:
4967:
4953:10.1118/1.596947
4939:(6): 1601â1605.
4924:
4918:
4917:
4915:
4913:
4907:
4901:. Archived from
4891:10.1118/1.597159
4877:(6): 1607â1610.
4868:
4859:
4853:
4852:
4850:
4848:
4838:
4829:
4823:
4822:
4812:
4788:
4782:
4781:
4779:
4777:
4768:. Archived from
4761:
4746:
4745:
4743:
4719:
4710:
4696:
4690:
4689:
4677:
4671:
4670:
4668:
4667:
4661:
4655:. Archived from
4630:
4621:
4615:
4614:
4606:
4597:
4596:
4585:10.1118/1.597458
4559:
4553:
4552:
4516:
4507:
4506:
4498:
4487:
4486:
4478:
4472:
4471:
4469:
4467:
4452:
4443:
4442:
4440:
4438:
4427:
4421:
4420:
4410:
4386:
4380:
4379:
4351:
4342:
4341:
4329:
4323:
4322:
4293:
4282:
4281:
4261:
4248:
4247:
4227:
4218:
4217:
4215:
4213:
4204:. Archived from
4197:
4188:
4187:
4150:
4144:
4143:
4133:
4124:(5): 1041â1047.
4109:
4103:
4102:
4092:
4067:
4061:
4060:
4040:
4031:
4030:
4001:
3995:
3994:
3976:
3950:
3941:
3935:
3934:
3906:
3900:
3899:
3881:
3857:
3851:
3850:
3825:(5): 1339â1344.
3814:
3808:
3807:
3778:
3772:
3771:
3727:
3721:
3720:
3683:
3677:
3676:
3647:
3638:
3637:
3620:(5): 1133â1135.
3609:
3603:
3602:
3565:
3559:
3558:
3526:
3520:
3519:
3517:
3516:
3507:. Archived from
3501:
3495:
3491:
3480:
3474:
3473:
3447:
3438:
3437:
3409:
3403:
3402:
3392:
3360:
3354:
3353:
3325:
3319:
3318:
3292:
3286:
3285:
3259:
3250:
3249:
3220:
3211:
3210:
3174:
3163:
3162:
3144:
3135:
3134:
3132:
3130:
3124:
3115:
3104:
3103:
3093:
3069:
3060:
3059:
3030:
3021:
3020:
3003:(4): 1048â1055.
2991:
2982:
2981:
2964:(6): 2151â2156.
2952:
2939:
2938:
2910:
2904:
2903:
2886:(5): 1432â1438.
2874:
2868:
2867:
2859:
2850:
2849:
2821:
2812:
2811:
2809:
2807:
2801:
2792:
2783:
2782:
2780:
2778:
2772:
2763:
2754:
2753:
2743:
2718:(10): CD007563.
2703:
2697:
2696:
2686:
2662:
2656:
2655:
2626:
2620:
2619:
2609:
2600:(7): 1325â1336.
2585:
2576:
2575:
2558:(5): 1329â1334.
2546:
2540:
2539:
2510:
2504:
2503:
2475:
2469:
2468:
2466:
2464:
2458:
2449:
2438:
2437:
2435:
2433:
2421:
2412:
2411:
2382:
2376:
2375:
2335:
2329:
2328:
2311:(5): 1424â1431.
2299:
2290:
2289:
2260:
2251:
2250:
2214:
2208:
2207:
2170:
2161:
2160:
2144:
2138:
2137:
2109:
2103:
2102:
2084:
2078:
2077:
2067:
2035:
2029:
2028:
2018:
2008:
1984:
1978:
1977:
1941:
1930:
1929:
1909:
1903:
1902:
1874:
1861:
1860:
1848:
1842:
1841:
1829:
1823:
1822:
1814:
1799:
1798:
1796:
1794:
1789:on April 4, 2009
1778:
1767:
1766:
1758:
1747:
1746:
1717:
1708:
1707:
1697:
1665:
1659:
1658:
1650:
1639:
1638:
1622:
1525:Nuclear medicine
1493:orphaned sources
1482:
1476:
1475:
1310:0.38 MeV (mean)
1214:
1116:Initial planning
1079:
1077:
1076:
1071:
1036:
1034:
1030:
1029:
1017:
1016:
1000:
980:
975:
974:
933:
931:
930:
925:
898:
896:
895:
890:
857:
855:
854:
849:
816:
814:
813:
808:
790:
788:
787:
782:
780:
779:
643:Source placement
120:radiation source
102:edit on Wikidata
94:
44:
32:
21:
7600:
7599:
7595:
7594:
7593:
7591:
7590:
7589:
7580:Medical physics
7565:
7564:
7561:
7556:
7544:
7538:
7529:
7408:
7406:
7399:
7395:Abscopal effect
7359:
7326:
7278:
7274:
7273:
7270:
7269:Unsealed source
7262:
7204:
7193:neutron-capture
7168:
7149:
7083:
7081:
7074:
7069:
7039:
7034:
6999:
6997:
6980:
6944:
6911:
6896:
6853:
6843:
6838:
6828:
6791:
6696:
6641:
6634:
6633:
6618:
6562:
6493:
6468:
6446:
6418:
6400:
6393:
6392:
6391:
6378:
6344:
6335:
6317:
6282:
6273:
6187:
6170:
6169:
6168:
6160:
6074:Natural fission
6028:
6027:
6015:
6010:
6000:
5983:
5959:Nuclear weapons
5938:
5897:Low-level (LLW)
5875:
5807:
5759:
5658:
5621:
5568:
5521:
5442:
5374:
5297:
5235:
5230:
5193:
5188:
5178:
5176:
5167:
5166:
5162:
5152:
5150:
5145:
5144:
5140:
5130:
5128:
5119:
5118:
5114:
5084:
5083:
5079:
5069:
5067:
5058:
5057:
5053:
5015:
5014:
5010:
4980:
4979:
4975:
4965:
4963:
4933:Medical Physics
4926:
4925:
4921:
4911:
4909:
4908:on 13 June 2021
4905:
4871:Medical Physics
4866:
4861:
4860:
4856:
4846:
4844:
4836:
4831:
4830:
4826:
4790:
4789:
4785:
4775:
4773:
4763:
4762:
4749:
4721:
4720:
4713:
4697:
4693:
4679:
4678:
4674:
4665:
4663:
4659:
4628:
4623:
4622:
4618:
4608:
4607:
4600:
4565:Medical Physics
4561:
4560:
4556:
4518:
4517:
4510:
4500:
4499:
4490:
4480:
4479:
4475:
4465:
4463:
4454:
4453:
4446:
4436:
4434:
4429:
4428:
4424:
4388:
4387:
4383:
4353:
4352:
4345:
4331:
4330:
4326:
4295:
4294:
4285:
4263:
4262:
4251:
4229:
4228:
4221:
4211:
4209:
4202:"Brachytherapy"
4199:
4198:
4191:
4152:
4151:
4147:
4111:
4110:
4106:
4069:
4068:
4064:
4042:
4041:
4034:
4003:
4002:
3998:
3948:
3943:
3942:
3938:
3908:
3907:
3903:
3859:
3858:
3854:
3816:
3815:
3811:
3780:
3779:
3775:
3729:
3728:
3724:
3685:
3684:
3680:
3649:
3648:
3641:
3611:
3610:
3606:
3567:
3566:
3562:
3528:
3527:
3523:
3514:
3512:
3503:
3502:
3498:
3482:
3481:
3477:
3470:
3449:
3448:
3441:
3411:
3410:
3406:
3362:
3361:
3357:
3327:
3326:
3322:
3315:
3294:
3293:
3289:
3282:
3261:
3260:
3253:
3222:
3221:
3214:
3176:
3175:
3166:
3159:
3146:
3145:
3138:
3128:
3126:
3122:
3117:
3116:
3107:
3071:
3070:
3063:
3032:
3031:
3024:
2993:
2992:
2985:
2954:
2953:
2942:
2912:
2911:
2907:
2876:
2875:
2871:
2861:
2860:
2853:
2823:
2822:
2815:
2805:
2803:
2799:
2794:
2793:
2786:
2776:
2774:
2770:
2765:
2764:
2757:
2705:
2704:
2700:
2664:
2663:
2659:
2628:
2627:
2623:
2594:Acta Oncologica
2587:
2586:
2579:
2548:
2547:
2543:
2512:
2511:
2507:
2477:
2476:
2472:
2462:
2460:
2456:
2451:
2450:
2441:
2431:
2429:
2423:
2422:
2415:
2384:
2383:
2379:
2337:
2336:
2332:
2301:
2300:
2293:
2262:
2261:
2254:
2216:
2215:
2211:
2172:
2171:
2164:
2146:
2145:
2141:
2111:
2110:
2106:
2099:
2086:
2085:
2081:
2050:(10): 694â701.
2037:
2036:
2032:
1986:
1985:
1981:
1943:
1942:
1933:
1920:(46): 916â917.
1911:
1910:
1906:
1876:
1875:
1864:
1850:
1849:
1845:
1831:
1830:
1826:
1816:
1815:
1802:
1792:
1790:
1780:
1779:
1770:
1760:
1759:
1750:
1719:
1718:
1711:
1667:
1666:
1662:
1652:
1651:
1642:
1624:
1623:
1548:
1544:
1501:
1489:
1390:Henri Becquerel
1386:
1209:
1181:
1164:
1147:
1135:
1118:
1105:
1097:prostate cancer
1085:
1021:
1008:
1001:
981:
966:
940:
939:
907:
906:
866:
865:
825:
824:
821:Geometry factor
799:
798:
771:
766:
765:
764:and denoted by
706:prostate cancer
687:
645:
625:
612:
587:
566:
557:
537:
494:
474:
458:
449:
432:
423:
410:
381:
353:prostate cancer
349:
343:
341:Prostate cancer
327:cervical cancer
323:
321:Cervical cancer
200:
118:where a sealed
105:
90:
47:
28:
23:
22:
15:
12:
11:
5:
7598:
7596:
7588:
7587:
7582:
7577:
7567:
7566:
7558:
7557:
7555:
7554:
7547:
7541:
7534:
7531:
7530:
7528:
7527:
7522:
7517:
7512:
7507:
7502:
7497:
7492:
7487:
7482:
7477:
7472:
7467:
7462:
7457:
7452:
7447:
7442:
7437:
7432:
7427:
7422:
7417:
7411:
7409:
7404:
7401:
7400:
7398:
7397:
7392:
7387:
7382:
7377:
7375:Radiation burn
7371:
7369:
7365:
7364:
7361:
7360:
7358:
7357:
7352:
7351:
7350:
7345:
7334:
7332:
7328:
7327:
7325:
7324:
7323:
7322:
7312:
7307:
7297:
7292:
7281:
7279:
7267:
7264:
7263:
7261:
7260:
7242:
7236:
7235:
7234:
7229:
7218:
7216:
7210:
7209:
7206:
7205:
7203:
7202:
7201:
7200:
7195:
7190:
7179:
7177:
7170:
7169:
7167:
7166:
7160:
7158:
7151:
7150:
7148:
7147:
7145:Cobalt therapy
7142:
7141:
7140:
7135:
7121:
7116:
7111:
7105:
7103:
7093:
7084:
7079:
7076:
7075:
7070:
7068:
7067:
7060:
7053:
7045:
7036:
7035:
7033:
7032:
7020:
7008:
6993:
6990:
6989:
6986:
6985:
6982:
6981:
6979:
6978:
6973:
6968:
6966:Muon-catalyzed
6963:
6958:
6952:
6950:
6946:
6945:
6943:
6942:
6937:
6932:
6927:
6926:
6925:
6915:
6906:
6904:
6898:
6897:
6895:
6894:
6889:
6884:
6879:
6874:
6869:
6863:
6861:
6855:
6854:
6848:
6845:
6844:
6837:
6830:
6829:
6827:
6826:
6821:
6820:
6819:
6814:
6803:
6801:
6797:
6796:
6793:
6792:
6790:
6789:
6784:
6779:
6774:
6773:
6772:
6767:
6762:
6757:
6752:
6747:
6742:
6737:
6732:
6727:
6722:
6717:
6706:
6704:
6698:
6697:
6695:
6694:
6689:
6684:
6679:
6674:
6669:
6664:
6659:
6657:Integral (IFR)
6654:
6648:
6642:
6631:
6628:
6627:
6624:
6623:
6620:
6619:
6617:
6616:
6611:
6606:
6601:
6596:
6591:
6585:
6583:
6574:
6568:
6567:
6564:
6563:
6561:
6560:
6559:
6558:
6553:
6552:
6551:
6546:
6541:
6536:
6521:
6516:
6515:
6514:
6503:
6501:
6495:
6494:
6492:
6491:
6486:
6481:
6472:
6470:
6466:
6458:
6452:
6451:
6448:
6447:
6445:
6444:
6439:
6434:
6429:
6423:
6421:
6416:
6408:
6401:
6387:
6384:
6383:
6380:
6379:
6377:
6376:
6375:
6374:
6369:
6364:
6359:
6348:
6346:
6342:
6337:
6336:
6334:
6333:
6327:
6325:
6319:
6318:
6316:
6315:
6310:
6305:
6304:
6303:
6298:
6287:
6285:
6280:
6275:
6274:
6272:
6271:
6270:
6269:
6264:
6259:
6254:
6249:
6248:
6247:
6242:
6237:
6227:
6222:
6221:
6220:
6215:
6212:
6209:
6206:
6192:
6190:
6185:
6177:
6162:
6161:
6159:
6158:
6153:
6152:
6151:
6148:
6143:
6138:
6137:
6136:
6131:
6121:
6116:
6111:
6106:
6101:
6096:
6091:
6086:
6076:
6071:
6070:
6069:
6064:
6059:
6054:
6044:
6038:
6036:
6030:
6029:
6021:
6020:
6017:
6016:
6009:
6002:
6001:
5996:
5989:
5988:
5985:
5984:
5982:
5981:
5976:
5974:Uranium mining
5971:
5966:
5961:
5956:
5950:
5948:
5944:
5943:
5940:
5939:
5937:
5936:
5931:
5930:
5929:
5924:
5914:
5909:
5904:
5899:
5894:
5889:
5883:
5881:
5877:
5876:
5874:
5873:
5868:
5867:
5866:
5856:
5851:
5850:
5849:
5847:Minor actinide
5844:
5839:
5828:
5826:
5819:
5813:
5812:
5809:
5808:
5806:
5805:
5800:
5795:
5790:
5789:
5788:
5783:
5773:
5767:
5765:
5761:
5760:
5758:
5757:
5756:
5755:
5745:
5740:
5739:
5738:
5733:
5723:
5718:
5713:
5712:
5711:
5701:
5696:
5691:
5686:
5681:
5675:
5673:
5666:
5660:
5659:
5657:
5656:
5651:
5646:
5641:
5635:
5633:
5627:
5626:
5623:
5622:
5620:
5619:
5614:
5609:
5604:
5599:
5594:
5589:
5584:
5578:
5576:
5570:
5569:
5567:
5566:
5561:
5556:
5551:
5546:
5544:Autoradiograph
5540:
5538:
5529:
5523:
5522:
5520:
5519:
5518:
5517:
5507:
5506:
5505:
5495:
5494:
5493:
5483:
5478:
5473:
5468:
5463:
5458:
5452:
5450:
5444:
5443:
5441:
5440:
5435:
5430:
5425:
5420:
5415:
5410:
5405:
5400:
5395:
5390:
5384:
5382:
5376:
5375:
5373:
5372:
5371:
5370:
5365:
5360:
5359:
5358:
5353:
5338:
5333:
5328:
5323:
5318:
5313:
5307:
5305:
5299:
5298:
5296:
5295:
5294:
5293:
5288:
5278:
5273:
5268:
5266:Atomic nucleus
5263:
5258:
5253:
5247:
5245:
5237:
5236:
5231:
5229:
5228:
5221:
5214:
5206:
5200:
5199:
5192:
5191:External links
5189:
5187:
5186:
5160:
5138:
5112:
5077:
5051:
5024:(6): 496â499.
5008:
4989:(6): 757â759.
4973:
4919:
4854:
4824:
4783:
4747:
4711:
4691:
4672:
4639:(2): 331â340.
4616:
4598:
4571:(2): 209â234.
4554:
4508:
4488:
4473:
4444:
4422:
4401:(4): 758â766.
4381:
4362:(3): 255â267.
4343:
4324:
4305:(2): 197â201.
4283:
4272:(7): 525â529.
4249:
4238:(3): 545â553.
4219:
4189:
4162:(6): 662â669.
4145:
4104:
4083:(8): 804â847.
4062:
4032:
4013:(3): 753â757.
3996:
3959:(6): 745â749.
3936:
3901:
3872:(2): 969â975.
3852:
3809:
3790:(3): 525â530.
3773:
3738:(8): 373â377.
3722:
3678:
3659:(3): 332â339.
3639:
3604:
3577:(5): 463â470.
3560:
3541:(3): S35âS36.
3521:
3496:
3475:
3468:
3439:
3420:(4): 367â372.
3404:
3375:(1): 274â280.
3355:
3330:Physica Medica
3320:
3313:
3287:
3280:
3251:
3212:
3164:
3157:
3136:
3105:
3061:
3042:(2): 114â120.
3022:
2983:
2940:
2905:
2869:
2851:
2813:
2784:
2755:
2698:
2677:(1): 117â124.
2657:
2621:
2577:
2541:
2522:(2): 316â321.
2505:
2486:(1): 104â109.
2470:
2439:
2413:
2394:(2): 485â490.
2377:
2330:
2291:
2252:
2209:
2182:(7): 470â478.
2162:
2139:
2120:(3): 223â230.
2104:
2097:
2079:
2030:
1979:
1931:
1904:
1885:(2): 150â156.
1862:
1843:
1824:
1800:
1768:
1748:
1729:(2): 168â173.
1709:
1680:(9): 896â905.
1660:
1640:
1545:
1543:
1540:
1539:
1538:
1532:
1527:
1522:
1517:
1512:
1507:
1500:
1497:
1488:
1485:
1440:while passing
1418:radium sulfate
1392:in 1896) when
1385:
1382:
1379:
1378:
1375:
1370:
1363:
1362:
1359:
1356:
1353:
1346:
1345:
1344:21 keV (mean)
1342:
1339:
1336:
1329:
1328:
1325:
1322:
1319:
1312:
1311:
1308:
1305:
1302:
1295:
1294:
1291:
1288:
1285:
1278:
1277:
1270:
1267:
1258:
1251:
1250:
1243:
1240:
1235:
1228:
1227:
1224:
1221:
1218:
1208:
1205:
1180:
1177:
1163:
1160:
1146:
1143:
1134:
1131:
1117:
1114:
1104:
1101:
1084:
1081:
1069:
1066:
1063:
1060:
1057:
1054:
1051:
1048:
1045:
1042:
1039:
1033:
1028:
1024:
1020:
1015:
1011:
1007:
1004:
999:
996:
993:
990:
987:
984:
978:
973:
969:
965:
962:
959:
956:
953:
950:
947:
936:
935:
923:
920:
917:
914:
900:
888:
885:
882:
879:
876:
873:
859:
847:
844:
841:
838:
835:
832:
818:
806:
792:
778:
774:
686:
683:
644:
641:
624:
621:
611:
608:
586:
583:
565:
562:
556:
553:
536:
533:
519:-188 to treat
493:
490:
473:
470:
457:
454:
448:
445:
431:
428:
422:
419:
409:
406:
380:
377:
345:Main article:
342:
339:
322:
319:
239:floor of mouth
199:
196:
107:
106:
99:
96:
95:
88:
82:
81:
76:
70:
69:
63:
57:
56:
53:
49:
48:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7597:
7586:
7583:
7581:
7578:
7576:
7573:
7572:
7570:
7563:
7552:
7548:
7542:
7536:
7535:
7532:
7526:
7523:
7521:
7518:
7516:
7513:
7511:
7508:
7506:
7503:
7501:
7498:
7496:
7493:
7491:
7488:
7486:
7483:
7481:
7478:
7476:
7475:Nanoimpellers
7473:
7471:
7468:
7466:
7463:
7461:
7458:
7456:
7453:
7451:
7448:
7446:
7443:
7441:
7438:
7436:
7433:
7431:
7428:
7426:
7423:
7421:
7418:
7416:
7413:
7412:
7410:
7402:
7396:
7393:
7391:
7388:
7386:
7383:
7381:
7378:
7376:
7373:
7372:
7370:
7366:
7356:
7353:
7349:
7346:
7344:
7341:
7340:
7339:
7336:
7335:
7333:
7329:
7321:
7318:
7317:
7316:
7313:
7311:
7308:
7305:
7301:
7298:
7296:
7293:
7290:
7286:
7283:
7282:
7280:
7272:
7265:
7258:
7254:
7250:
7246:
7243:
7240:
7237:
7233:
7230:
7228:
7225:
7224:
7223:
7220:
7219:
7217:
7215:
7214:Brachytherapy
7211:
7199:
7196:
7194:
7191:
7189:
7186:
7185:
7184:
7181:
7180:
7178:
7176:
7171:
7165:
7162:
7161:
7159:
7157:
7152:
7146:
7143:
7139:
7136:
7134:
7131:
7130:
7129:
7125:
7122:
7120:
7117:
7115:
7112:
7110:
7107:
7106:
7104:
7102:
7097:
7094:
7092:
7088:
7085:
7077:
7073:
7066:
7061:
7059:
7054:
7052:
7047:
7046:
7043:
7031:
7030:
7021:
7019:
7018:
7009:
7007:
7006:
6995:
6994:
6991:
6977:
6974:
6972:
6969:
6967:
6964:
6962:
6959:
6957:
6954:
6953:
6951:
6947:
6941:
6938:
6936:
6933:
6931:
6928:
6924:
6923:electrostatic
6921:
6920:
6919:
6916:
6914:
6908:
6907:
6905:
6903:
6899:
6893:
6890:
6888:
6885:
6883:
6880:
6878:
6875:
6873:
6870:
6868:
6865:
6864:
6862:
6860:
6856:
6852:
6846:
6841:
6835:
6825:
6822:
6818:
6815:
6813:
6810:
6809:
6808:
6805:
6804:
6802:
6798:
6788:
6785:
6783:
6780:
6778:
6775:
6771:
6768:
6766:
6763:
6761:
6758:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6718:
6716:
6713:
6712:
6711:
6708:
6707:
6705:
6703:
6702:Generation IV
6699:
6693:
6690:
6688:
6685:
6683:
6680:
6678:
6675:
6673:
6670:
6668:
6665:
6663:
6660:
6658:
6655:
6653:
6652:Breeder (FBR)
6650:
6649:
6646:
6643:
6638:
6629:
6615:
6612:
6610:
6607:
6605:
6602:
6600:
6597:
6595:
6592:
6590:
6587:
6586:
6584:
6582:
6578:
6575:
6573:
6569:
6557:
6554:
6550:
6547:
6545:
6542:
6540:
6537:
6535:
6532:
6531:
6530:
6527:
6526:
6525:
6522:
6520:
6517:
6513:
6510:
6509:
6508:
6505:
6504:
6502:
6500:
6496:
6490:
6487:
6485:
6482:
6480:
6478:
6474:
6473:
6471:
6469:
6462:
6459:
6457:
6453:
6443:
6440:
6438:
6435:
6433:
6430:
6428:
6425:
6424:
6422:
6420:
6412:
6409:
6405:
6402:
6397:
6390:
6385:
6373:
6370:
6368:
6365:
6363:
6360:
6358:
6355:
6354:
6353:
6350:
6349:
6347:
6345:
6338:
6332:
6329:
6328:
6326:
6324:
6320:
6314:
6311:
6309:
6306:
6302:
6299:
6297:
6294:
6293:
6292:
6289:
6288:
6286:
6284:
6276:
6268:
6265:
6263:
6260:
6258:
6255:
6253:
6250:
6246:
6243:
6241:
6238:
6236:
6233:
6232:
6231:
6228:
6226:
6223:
6219:
6216:
6213:
6210:
6207:
6204:
6203:
6202:
6199:
6198:
6197:
6194:
6193:
6191:
6189:
6181:
6178:
6174:
6167:
6163:
6157:
6154:
6149:
6147:
6144:
6142:
6139:
6135:
6132:
6130:
6127:
6126:
6125:
6122:
6120:
6117:
6115:
6112:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6081:
6080:
6077:
6075:
6072:
6068:
6065:
6063:
6060:
6058:
6055:
6053:
6050:
6049:
6048:
6045:
6043:
6040:
6039:
6037:
6035:
6031:
6026:
6025:
6018:
6013:
6007:
6003:
5999:
5994:
5990:
5980:
5977:
5975:
5972:
5970:
5967:
5965:
5962:
5960:
5957:
5955:
5954:Nuclear power
5952:
5951:
5949:
5945:
5935:
5934:Transmutation
5932:
5928:
5925:
5923:
5920:
5919:
5918:
5915:
5913:
5910:
5908:
5905:
5903:
5900:
5898:
5895:
5893:
5890:
5888:
5885:
5884:
5882:
5878:
5872:
5869:
5865:
5862:
5861:
5860:
5857:
5855:
5852:
5848:
5845:
5843:
5840:
5838:
5835:
5834:
5833:
5830:
5829:
5827:
5823:
5820:
5818:
5814:
5804:
5801:
5799:
5796:
5794:
5791:
5787:
5784:
5782:
5779:
5778:
5777:
5774:
5772:
5769:
5768:
5766:
5762:
5754:
5751:
5750:
5749:
5746:
5744:
5741:
5737:
5734:
5732:
5731:high-altitude
5729:
5728:
5727:
5724:
5722:
5721:Proliferation
5719:
5717:
5714:
5710:
5707:
5706:
5705:
5702:
5700:
5697:
5695:
5692:
5690:
5687:
5685:
5682:
5680:
5677:
5676:
5674:
5670:
5667:
5665:
5661:
5655:
5652:
5650:
5647:
5645:
5642:
5640:
5637:
5636:
5634:
5632:
5628:
5618:
5615:
5613:
5610:
5608:
5607:Brachytherapy
5605:
5603:
5600:
5598:
5595:
5593:
5590:
5588:
5585:
5583:
5580:
5579:
5577:
5575:
5571:
5565:
5562:
5560:
5557:
5555:
5552:
5550:
5547:
5545:
5542:
5541:
5539:
5537:
5533:
5530:
5528:
5524:
5516:
5513:
5512:
5511:
5508:
5504:
5501:
5500:
5499:
5496:
5492:
5489:
5488:
5487:
5484:
5482:
5479:
5477:
5474:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5453:
5451:
5449:
5445:
5439:
5436:
5434:
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5414:
5411:
5409:
5406:
5404:
5403:Cross section
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5385:
5383:
5381:
5377:
5369:
5366:
5364:
5361:
5357:
5354:
5352:
5349:
5348:
5347:
5344:
5343:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5322:
5319:
5317:
5314:
5312:
5309:
5308:
5306:
5304:
5300:
5292:
5289:
5287:
5284:
5283:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5248:
5246:
5242:
5238:
5234:
5227:
5222:
5220:
5215:
5213:
5208:
5207:
5204:
5198:
5195:
5194:
5190:
5175:
5171:
5164:
5161:
5149:
5142:
5139:
5126:
5122:
5116:
5113:
5108:
5104:
5100:
5096:
5092:
5088:
5087:Brachytherapy
5081:
5078:
5066:
5062:
5055:
5052:
5047:
5043:
5039:
5035:
5031:
5027:
5023:
5019:
5012:
5009:
5004:
5000:
4996:
4992:
4988:
4984:
4977:
4974:
4962:
4958:
4954:
4950:
4946:
4942:
4938:
4934:
4930:
4923:
4920:
4904:
4900:
4896:
4892:
4888:
4884:
4880:
4876:
4872:
4865:
4858:
4855:
4842:
4835:
4828:
4825:
4820:
4816:
4811:
4806:
4802:
4798:
4794:
4787:
4784:
4771:
4767:
4760:
4758:
4756:
4754:
4752:
4748:
4742:
4737:
4733:
4729:
4725:
4718:
4716:
4712:
4709:
4706:
4705:9789048130955
4702:
4695:
4692:
4687:
4683:
4676:
4673:
4662:on 2015-10-17
4658:
4654:
4650:
4646:
4642:
4638:
4634:
4627:
4620:
4617:
4612:
4605:
4603:
4599:
4594:
4590:
4586:
4582:
4578:
4574:
4570:
4566:
4558:
4555:
4550:
4546:
4542:
4538:
4534:
4530:
4526:
4522:
4515:
4513:
4509:
4504:
4497:
4495:
4493:
4489:
4484:
4477:
4474:
4461:
4457:
4451:
4449:
4445:
4433:
4426:
4423:
4418:
4414:
4409:
4404:
4400:
4396:
4392:
4385:
4382:
4377:
4373:
4369:
4365:
4361:
4357:
4350:
4348:
4344:
4339:
4335:
4334:Medicina Oral
4328:
4325:
4320:
4316:
4312:
4308:
4304:
4300:
4292:
4290:
4288:
4284:
4279:
4275:
4271:
4267:
4260:
4258:
4256:
4254:
4250:
4245:
4241:
4237:
4233:
4226:
4224:
4220:
4207:
4203:
4196:
4194:
4190:
4185:
4181:
4177:
4173:
4169:
4165:
4161:
4157:
4149:
4146:
4141:
4137:
4132:
4127:
4123:
4119:
4115:
4108:
4105:
4100:
4096:
4091:
4086:
4082:
4078:
4074:
4066:
4063:
4058:
4054:
4050:
4046:
4039:
4037:
4033:
4028:
4024:
4020:
4016:
4012:
4008:
4000:
3997:
3992:
3988:
3984:
3980:
3975:
3970:
3966:
3962:
3958:
3954:
3947:
3940:
3937:
3932:
3928:
3924:
3920:
3917:(1): 95â102.
3916:
3912:
3905:
3902:
3897:
3893:
3889:
3885:
3880:
3875:
3871:
3867:
3863:
3856:
3853:
3848:
3844:
3840:
3836:
3832:
3828:
3824:
3820:
3813:
3810:
3805:
3801:
3797:
3793:
3789:
3785:
3777:
3774:
3769:
3765:
3761:
3757:
3753:
3749:
3745:
3741:
3737:
3733:
3726:
3723:
3718:
3714:
3710:
3706:
3702:
3698:
3694:
3690:
3682:
3679:
3674:
3670:
3666:
3662:
3658:
3654:
3646:
3644:
3640:
3635:
3631:
3627:
3623:
3619:
3615:
3608:
3605:
3600:
3596:
3592:
3588:
3584:
3580:
3576:
3572:
3571:Brachytherapy
3564:
3561:
3556:
3552:
3548:
3544:
3540:
3536:
3535:Brachytherapy
3532:
3525:
3522:
3511:on 2019-12-21
3510:
3506:
3500:
3497:
3494:
3489:
3485:
3479:
3476:
3471:
3469:9783540880059
3465:
3461:
3457:
3453:
3446:
3444:
3440:
3435:
3431:
3427:
3423:
3419:
3415:
3414:Brachytherapy
3408:
3405:
3400:
3396:
3391:
3386:
3382:
3378:
3374:
3370:
3366:
3359:
3356:
3351:
3347:
3343:
3339:
3335:
3331:
3324:
3321:
3316:
3314:9783540880059
3310:
3306:
3302:
3298:
3291:
3288:
3283:
3281:9783540880059
3277:
3273:
3269:
3265:
3258:
3256:
3252:
3247:
3243:
3239:
3235:
3231:
3227:
3219:
3217:
3213:
3208:
3204:
3200:
3196:
3192:
3188:
3184:
3180:
3173:
3171:
3169:
3165:
3160:
3154:
3150:
3143:
3141:
3137:
3121:
3114:
3112:
3110:
3106:
3101:
3097:
3092:
3087:
3083:
3079:
3075:
3068:
3066:
3062:
3057:
3053:
3049:
3045:
3041:
3037:
3029:
3027:
3023:
3018:
3014:
3010:
3006:
3002:
2998:
2990:
2988:
2984:
2979:
2975:
2971:
2967:
2963:
2959:
2951:
2949:
2947:
2945:
2941:
2936:
2932:
2928:
2924:
2920:
2916:
2909:
2906:
2901:
2897:
2893:
2889:
2885:
2881:
2873:
2870:
2865:
2858:
2856:
2852:
2847:
2843:
2839:
2835:
2831:
2827:
2820:
2818:
2814:
2798:
2791:
2789:
2785:
2769:
2762:
2760:
2756:
2751:
2747:
2742:
2737:
2733:
2729:
2725:
2721:
2717:
2713:
2709:
2702:
2699:
2694:
2690:
2685:
2680:
2676:
2672:
2668:
2661:
2658:
2653:
2649:
2645:
2641:
2637:
2633:
2625:
2622:
2617:
2613:
2608:
2603:
2599:
2595:
2591:
2584:
2582:
2578:
2573:
2569:
2565:
2561:
2557:
2553:
2545:
2542:
2537:
2533:
2529:
2525:
2521:
2517:
2509:
2506:
2501:
2497:
2493:
2489:
2485:
2481:
2474:
2471:
2455:
2448:
2446:
2444:
2440:
2427:
2420:
2418:
2414:
2409:
2405:
2401:
2397:
2393:
2389:
2381:
2378:
2373:
2369:
2365:
2361:
2357:
2353:
2349:
2345:
2341:
2334:
2331:
2326:
2322:
2318:
2314:
2310:
2306:
2298:
2296:
2292:
2287:
2283:
2279:
2275:
2271:
2267:
2266:Brachytherapy
2259:
2257:
2253:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2220:
2213:
2210:
2205:
2201:
2197:
2193:
2189:
2185:
2181:
2177:
2169:
2167:
2163:
2158:
2154:
2150:
2143:
2140:
2135:
2131:
2127:
2123:
2119:
2115:
2114:Brachytherapy
2108:
2105:
2100:
2094:
2090:
2083:
2080:
2075:
2071:
2066:
2061:
2057:
2053:
2049:
2045:
2041:
2034:
2031:
2026:
2022:
2017:
2012:
2007:
2002:
1998:
1994:
1990:
1983:
1980:
1975:
1971:
1967:
1963:
1959:
1955:
1952:(3): 269â87.
1951:
1947:
1940:
1938:
1936:
1932:
1927:
1923:
1919:
1915:
1908:
1905:
1900:
1896:
1892:
1888:
1884:
1880:
1873:
1871:
1869:
1867:
1863:
1859:
1854:
1847:
1844:
1840:
1835:
1828:
1825:
1820:
1813:
1811:
1809:
1807:
1805:
1801:
1788:
1784:
1777:
1775:
1773:
1769:
1764:
1757:
1755:
1753:
1749:
1744:
1740:
1736:
1732:
1728:
1724:
1716:
1714:
1710:
1705:
1701:
1696:
1691:
1687:
1683:
1679:
1675:
1671:
1664:
1661:
1656:
1649:
1647:
1645:
1641:
1636:
1632:
1628:
1621:
1619:
1617:
1615:
1613:
1611:
1609:
1607:
1605:
1603:
1601:
1599:
1597:
1595:
1593:
1591:
1589:
1587:
1585:
1583:
1581:
1579:
1577:
1575:
1573:
1571:
1569:
1567:
1565:
1563:
1561:
1559:
1557:
1555:
1553:
1551:
1547:
1541:
1536:
1533:
1531:
1528:
1526:
1523:
1521:
1518:
1516:
1513:
1511:
1508:
1506:
1503:
1502:
1498:
1496:
1494:
1486:
1484:
1481:
1470:
1465:
1463:
1457:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1426:
1422:
1419:
1415:
1414:William Duane
1410:
1408:
1403:
1399:
1396:suggested to
1395:
1391:
1383:
1376:
1374:
1371:
1368:
1365:
1364:
1360:
1357:
1354:
1351:
1350:Ruthenium-106
1348:
1347:
1343:
1340:
1337:
1334:
1333:Palladium-103
1331:
1330:
1326:
1323:
1320:
1317:
1314:
1313:
1309:
1306:
1303:
1300:
1297:
1296:
1292:
1289:
1286:
1283:
1280:
1279:
1275:
1272:0.512, 0.662
1271:
1268:
1266:
1262:
1259:
1256:
1253:
1252:
1248:
1244:
1241:
1239:
1236:
1233:
1230:
1229:
1225:
1222:
1219:
1217:Radionuclide
1216:
1215:
1212:
1206:
1204:
1200:
1196:
1192:
1188:
1185:
1178:
1176:
1168:
1161:
1159:
1151:
1144:
1142:
1138:
1132:
1130:
1126:
1122:
1115:
1109:
1102:
1100:
1098:
1092:
1088:
1082:
1080:
1067:
1061:
1058:
1055:
1049:
1043:
1037:
1026:
1022:
1018:
1013:
1009:
1002:
994:
991:
988:
982:
971:
967:
963:
957:
954:
951:
945:
918:
912:
904:
901:
883:
880:
877:
871:
863:
860:
842:
839:
836:
830:
822:
819:
796:
793:
776:
772:
763:
759:
756:
755:
754:
752:
742:
738:
734:
732:
728:
724:
720:
716:
711:
708:
707:
703:
699:
694:
692:
684:
682:
680:
676:
672:
668:
664:
660:
656:
651:
648:
642:
640:
638:
634:
630:
622:
620:
616:
609:
607:
603:
601:
597:
591:
584:
582:
578:
574:
570:
563:
561:
554:
552:
550:
546:
542:
535:Blood vessels
534:
532:
528:
526:
522:
518:
514:
509:
507:
503:
499:
491:
489:
486:
484:
479:
471:
469:
466:
464:
463:glioblastomas
455:
453:
446:
444:
440:
438:
429:
427:
420:
418:
416:
407:
405:
401:
397:
394:
393:breast cancer
390:
386:
379:Breast cancer
378:
376:
372:
370:
366:
362:
356:
354:
348:
340:
338:
335:
331:
328:
320:
318:
314:
310:
306:
302:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
227:
225:
221:
217:
213:
204:
197:
195:
191:
187:
183:
180:
176:
172:
168:
164:
159:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
114:is a form of
113:
112:Brachytherapy
103:
93:
89:
87:
83:
80:
77:
75:
71:
67:
64:
62:
58:
54:
50:
43:
38:
35:Brachytherapy
33:
30:
19:
7562:
7551:radioisotope
7465:Monitor unit
7435:Dose profile
7405:Features and
7271:radiotherapy
7251: /
7247: /
7213:
7188:fast neutron
7126: /
7124:Radiosurgery
7027:
7015:
6996:
6976:Pyroelectric
6930:Laser-driven
6710:Sodium (SFR)
6637:fast-neutron
6476:
6022:
5912:Reprocessing
5793:WMD treaties
5612:Radiosurgery
5606:
5582:Fast-neutron
5554:Scintigraphy
5177:. Retrieved
5174:Radio Prague
5173:
5163:
5151:. Retrieved
5141:
5129:. Retrieved
5124:
5115:
5093:(1): 55â59.
5090:
5086:
5080:
5068:. Retrieved
5064:
5054:
5021:
5017:
5011:
4986:
4982:
4976:
4964:. Retrieved
4936:
4932:
4922:
4910:. Retrieved
4903:the original
4874:
4870:
4857:
4845:. Retrieved
4840:
4832:Bridgman P.
4827:
4800:
4796:
4786:
4776:25 September
4774:. Retrieved
4770:the original
4734:(2): 31â38.
4731:
4727:
4694:
4685:
4675:
4664:. Retrieved
4657:the original
4636:
4632:
4619:
4610:
4568:
4564:
4557:
4524:
4520:
4502:
4482:
4476:
4464:. Retrieved
4459:
4437:25 September
4435:. Retrieved
4425:
4398:
4394:
4384:
4359:
4355:
4337:
4333:
4327:
4302:
4298:
4269:
4265:
4235:
4231:
4212:25 September
4210:. Retrieved
4206:the original
4159:
4155:
4148:
4121:
4117:
4107:
4080:
4076:
4065:
4048:
4044:
4010:
4006:
3999:
3956:
3952:
3939:
3914:
3910:
3904:
3869:
3865:
3855:
3822:
3818:
3812:
3787:
3783:
3776:
3735:
3731:
3725:
3692:
3688:
3681:
3656:
3652:
3617:
3613:
3607:
3574:
3570:
3563:
3538:
3534:
3524:
3513:. Retrieved
3509:the original
3499:
3487:
3478:
3451:
3417:
3413:
3407:
3372:
3368:
3358:
3336:(2): 80â87.
3333:
3329:
3323:
3296:
3290:
3263:
3232:(1): 83â91.
3229:
3225:
3182:
3178:
3148:
3129:25 September
3127:. Retrieved
3081:
3077:
3039:
3035:
3000:
2996:
2961:
2957:
2921:(1): 43â49.
2918:
2914:
2908:
2883:
2879:
2872:
2863:
2832:(1): 23â28.
2829:
2825:
2806:25 September
2804:. Retrieved
2777:25 September
2775:. Retrieved
2715:
2711:
2701:
2674:
2670:
2660:
2638:(1): 67â77.
2635:
2631:
2624:
2597:
2593:
2555:
2551:
2544:
2519:
2515:
2508:
2483:
2479:
2473:
2463:25 September
2461:. Retrieved
2432:25 September
2430:. Retrieved
2391:
2387:
2380:
2347:
2343:
2333:
2308:
2304:
2272:(1): 15â22.
2269:
2265:
2222:
2218:
2212:
2179:
2175:
2156:
2152:
2142:
2117:
2113:
2107:
2088:
2082:
2047:
2043:
2033:
1996:
1992:
1982:
1949:
1945:
1917:
1913:
1907:
1882:
1878:
1856:
1846:
1837:
1827:
1818:
1793:25 September
1791:. Retrieved
1787:the original
1762:
1726:
1722:
1677:
1673:
1663:
1654:
1626:
1490:
1466:
1458:
1427:
1423:
1411:
1394:Pierre Curie
1387:
1269:30.17 years
1210:
1201:
1197:
1193:
1189:
1186:
1182:
1173:
1156:
1139:
1136:
1127:
1123:
1119:
1093:
1089:
1086:
937:
902:
861:
820:
794:
757:
747:
735:
712:
709:
695:
688:
652:
649:
646:
626:
617:
613:
604:
592:
588:
579:
575:
571:
567:
558:
555:Side effects
538:
529:
510:
495:
487:
475:
467:
459:
456:Brain tumors
450:
441:
433:
424:
411:
404:HDR source.
402:
398:
382:
373:
369:incontinence
357:
350:
336:
332:
324:
315:
311:
307:
303:
263:gall bladder
228:
209:
198:Medical uses
192:
188:
184:
167:radionuclide
160:
156:chemotherapy
123:
111:
110:
29:
7355:Tomotherapy
7253:TheraSphere
7249:SIR-Spheres
7138:Gamma Knife
7091:Teletherapy
6887:Stellarator
6851:confinement
6745:Superphénix
6572:Molten-salt
6524:VHTR (HTGR)
6301:HW BLWR 250
6267:R4 Marviken
6196:Pressurized
6166:Heavy water
6150:many others
6079:Pressurized
6034:Light water
5736:underground
5694:Disarmament
5602:Tomotherapy
5597:Proton-beam
5461:Power plant
5423:Temperature
5256:Engineering
5179:21 November
5153:12 November
5131:12 November
4527:(1): 63â8.
3185:(1): 7â24.
2350:(1): 22â9.
1858:technology.
1407:Robert Abbe
1377:1599 years
1358:1.02 years
1299:Iridium-192
1290:5.26 years
1255:Caesium-137
1232:Caesium-131
1220:Decay mode
513:Skin Cancer
498:skin cancer
492:Skin cancer
483:afterloader
437:afterloader
415:afterloader
243:nasopharynx
179:caesium-131
148:skin cancer
52:Other names
7569:Categories
7425:Bragg peak
7368:Conditions
7300:Lexidronam
7285:Iobenguane
7133:Cyberknife
6912:(acoustic)
6529:PBR (PBMR)
5917:Spent fuel
5907:Repository
5887:Fuel cycle
5854:Activation
5631:Processing
5498:Propulsion
5456:by country
5388:Activation
5070:12 October
4666:2010-03-11
4460:RT Answers
3974:2108/59410
3689:The Lancet
3515:2020-04-15
1851:CSIntell.
1832:CSIntell.
1542:References
1442:gamma rays
1367:Radium-226
1341:17.0 days
1324:59.6 days
1316:Iodine-125
1307:73.8 days
1223:Half-life
698:oropharynx
671:oesophagus
521:basal cell
500:, such as
389:mastectomy
385:lumpectomy
267:bile-ducts
259:oesophagus
247:oropharynx
241:, tongue,
175:iodine-125
144:esophageal
61:ICD-10-PCS
7455:Isocenter
7450:Dosimetry
7407:equipment
7241: (I)
7082:therapies
6882:Spheromak
6581:Fluorides
6245:IPHWR-700
6240:IPHWR-540
6235:IPHWR-220
6024:Moderator
5704:Explosion
5679:Arms race
5466:Economics
5418:Reflector
5413:Radiation
5408:Generator
5363:Plutonium
5316:Deuterium
5281:Radiation
5251:Chemistry
4340:: E223â9.
3888:0954-6634
3839:0360-3016
3752:0288-2043
3591:1538-4721
3555:196511749
2732:1465-1858
1438:beta rays
1361:3.54 MeV
1282:Cobalt-60
1242:9.7 days
1133:Insertion
1103:Procedure
1062:θ
1023:θ
995:θ
977:Λ
958:θ
884:θ
843:θ
805:Λ
719:esophagus
685:Dose rate
585:Long-term
365:impotence
171:cobalt-60
7553:therapy.
7460:Mobetron
7343:electron
7222:Prostate
7156:electron
7080:Specific
7017:Category
6971:Polywell
6902:Inertial
6859:Magnetic
6614:TMSR-LF1
6609:TMSR-500
6589:Fuji MSR
6549:THTR-300
6389:Graphite
6252:PHWR KWU
6218:ACR-1000
6146:IPWR-900
6129:ACPR1000
6124:HPR-1000
6114:CPR-1000
6089:APR-1400
5880:Disposal
5832:Actinide
5825:Products
5684:Delivery
5527:Medicine
5356:depleted
5351:enriched
5321:Helium-3
5286:ionizing
5146:Motl L.
5125:iDNES.cz
5107:18299114
5046:36790323
5038:13564019
4819:29079418
4653:19846230
4549:32151003
4521:Adv Urol
4417:18181095
4376:19442516
4319:18954913
4278:15301172
4184:22161263
4176:16836719
4140:12021726
4099:15769784
4027:15927410
3991:26912830
3983:18681873
3931:10758310
3896:32648530
3847:16029790
3804:10078632
3760:17952540
3717:29529166
3709:15500894
3673:28104297
3599:23434221
3434:19744892
3399:20160680
3350:19836283
3246:19268900
3207:20971836
3199:19225919
3100:19046556
3056:17531335
3017:15001244
2978:17509305
2935:19570619
2900:19036530
2846:15066292
2750:25300170
2693:11815967
2652:16403584
2616:18661430
2572:19409728
2536:19586673
2500:19619956
2408:17336465
2372:23210347
2364:16404517
2325:15275728
2286:19734106
2247:25926233
2239:17455209
2204:22946298
2196:19574206
2153:Oncology
2134:18579448
2074:11089712
2025:18627617
1974:36764232
1966:15161320
1926:12143240
1899:19329209
1743:19748692
1704:29509865
1635:52988578
1499:See also
1450:tantalum
1304:ÎČ, Δ, Îł
731:prostate
702:sarcomas
216:prostate
136:prostate
132:cervical
74:ICD-9-CM
7415:BEAMnrc
7302: (
7287: (
7255: (
7029:Commons
6940:Z-pinch
6910:Bubble
6892:Tokamak
6755:FBR-600
6735:CFR-600
6730:BN-1200
6396:coolant
6323:Organic
6208:CANDU 9
6205:CANDU 6
6173:coolant
6134:ACP1000
6109:CAP1400
6047:Boiling
6012:Fission
5859:Fission
5803:Weapons
5743:Warfare
5726:Testing
5716:History
5709:effects
5664:Weapons
5574:Therapy
5549:RadBall
5536:Imaging
5428:Thermal
5393:Capture
5380:Neutron
5368:Thorium
5346:Uranium
5311:Tritium
5291:braking
5271:Fission
5261:Physics
5244:Science
5003:1137421
4966:15 June
4961:8309431
4941:Bibcode
4912:16 June
4899:8309432
4879:Bibcode
4847:16 June
4764:Nag S.
4593:7565352
4573:Bibcode
4541:2735748
4466:24 July
4244:9127366
3768:7294379
3634:1938510
3493:Summary
3390:5719777
2741:8734152
2065:1495597
2016:2494997
1695:5885899
1480:brachys
1454:iridium
1384:History
1276:Îł-rays
1249:(mean)
1226:Energy
727:breasts
667:trachea
517:Rhenium
283:urethra
279:bladder
255:bronchi
251:trachea
92:D001918
7490:Pencil
7348:TARGIT
7198:proton
7175:hadron
7101:photon
6840:Fusion
6800:Others
6740:Phénix
6725:BN-800
6720:BN-600
6715:BN-350
6544:HTR-PM
6539:HTR-10
6519:UHTREX
6484:Magnox
6479:(UNGG)
6372:Lucens
6367:KS 150
6104:ATMEA1
6084:AP1000
6067:Kerena
5947:Debate
5699:Ethics
5689:Design
5672:Topics
5503:rocket
5481:Fusion
5476:Policy
5438:Fusion
5398:Poison
5276:Fusion
5105:
5044:
5036:
5001:
4959:
4897:
4817:
4708:Pg 191
4703:
4651:
4591:
4547:
4539:
4415:
4395:Cancer
4374:
4317:
4276:
4242:
4182:
4174:
4138:
4097:
4025:
3989:
3981:
3929:
3894:
3886:
3845:
3837:
3802:
3766:
3758:
3750:
3715:
3707:
3671:
3632:
3597:
3589:
3553:
3466:
3432:
3397:
3387:
3348:
3311:
3278:
3244:
3205:
3197:
3155:
3098:
3054:
3015:
2976:
2933:
2898:
2844:
2748:
2738:
2730:
2691:
2671:Cancer
2650:
2614:
2570:
2534:
2498:
2428:. NICE
2406:
2370:
2362:
2323:
2284:
2245:
2237:
2219:Cancer
2202:
2194:
2132:
2095:
2072:
2062:
2023:
2013:
1999:: 20.
1972:
1964:
1924:
1897:
1741:
1702:
1692:
1633:
1474:ÎČÏαÏÏÏ
1446:Cobalt
715:cervix
663:vagina
659:uterus
655:cervix
596:Viagra
295:vagina
291:uterus
271:rectum
222:, and
220:breast
212:cervix
140:breast
124:Brachy
7420:Bolus
7331:Other
6961:Migma
6949:Other
6918:Fusor
6817:Piqua
6812:Arbus
6770:PRISM
6512:MHR-T
6507:GTMHR
6437:EGP-6
6432:AMB-X
6407:Water
6352:HWGCR
6291:HWLWR
6230:IPHWR
6201:CANDU
6062:ESBWR
5817:Waste
5781:Tests
5764:Lists
5748:Yield
5491:MMRTG
5448:Power
5042:S2CID
4906:(PDF)
4867:(PDF)
4837:(PDF)
4660:(PDF)
4629:(PDF)
4545:S2CID
4180:S2CID
3987:S2CID
3949:(PDF)
3764:S2CID
3713:S2CID
3551:S2CID
3203:S2CID
3123:(PDF)
2800:(PDF)
2771:(PDF)
2457:(PDF)
2368:S2CID
2243:S2CID
2200:S2CID
1970:S2CID
1471:word
1469:Greek
1430:radon
1369:(Ra)
1352:(Ru)
1335:(Pd)
1301:(Ir)
1287:ÎČ, Îł
1284:(Co)
1257:(Cs)
1245:30.4
1234:(Cs)
723:lungs
691:Grays
623:Types
564:Acute
299:vulva
287:penis
231:brain
128:Greek
100:[
79:92.27
6777:Lead
6760:CEFR
6750:PFBR
6632:None
6442:RBMK
6427:AM-1
6357:EL-4
6331:WR-1
6313:AHWR
6257:MZFR
6225:CVTR
6214:AFCR
6141:VVER
6099:APWR
6094:APR+
6057:ABWR
5927:cask
5922:pool
5864:LLFP
5753:TNTe
5433:Fast
5303:Fuel
5181:2012
5155:2012
5133:2012
5103:PMID
5072:2021
5034:PMID
4999:PMID
4968:2021
4957:PMID
4914:2021
4895:PMID
4849:2021
4815:PMID
4778:2009
4701:ISBN
4649:PMID
4589:PMID
4537:PMID
4468:2017
4439:2009
4413:PMID
4372:PMID
4315:PMID
4274:PMID
4240:PMID
4214:2009
4172:PMID
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