2116:
2096:
579:
367:
To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before
564:
664:
1837:
368:
scheduled surgery. Canagliflozin, dapagliflozin, and empagliflozin should each be stopped at least three days before, and ertugliflozin should be stopped at least four days before scheduled surgery.
552:
146:
2161:
657:
1830:
446:
439:"Invokamet- canagliflozin and metformin hydrochloride tablet, film coated Invokamet XR- canagliflozin and metformin hydrochloride tablet, film coated, extended release"
650:
1823:
84:
527:
2215:
2154:
1240:
642:
505:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
1777:
867:
333:
Canagliflozin/metformin was approved for medical use in the
European Union in April 2014, and for use in the United States in August 2014.
492:
2185:
2147:
1634:
1337:
438:
407:
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102:
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872:
132:
1689:
1684:
1759:
1719:
1679:
1542:
602:"Fixed-Dose Combination of Canagliflozin and Metformin for the Treatment of Type 2 Diabetes: An Overview"
2190:
1849:
1749:
1734:
1669:
1664:
1609:
371:
Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing.
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2200:
2195:
2180:
2123:
674:
302:
242:
139:
1914:
1361:
1131:
516:"Drug Approval Package: Invokamet (canagliflozin and metformin hydrochloride) Tablets NDA #204353"
2024:
1381:
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1310:
956:
843:
729:
631:
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190:
74:
2004:
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326:
291:
2100:
770:
752:
346:
298:
50:
1815:
400:"Vokanamet 50 mg/850 mg film-coated tablets - Summary of Product Characteristics (SmPC)"
33:
2131:
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2014:
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1919:
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94:
45:
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342:
88:
62:
57:
635:
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1478:
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116:
17:
553:"FDA revises labels of SGLT2 inhibitors for diabetes to include warning"
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678:
1052:
271:
1056:
582:
This article incorporates text from this source, which is in the
324:(thrush, a fungal infection of the female genital area caused by
349:
as an adjunct to diet and exercise to improve glycemic control.
301:. It is used in combination with diet and exercise. It is taken
262:
221:
196:
1819:
907:
698:
646:
209:
111:
547:
545:
312:(low blood glucose levels) when used in combination with
185:
2135:
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2035:
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2033:
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56:
44:
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27:Fixed-dose combination anti-diabetic medication
345:in adults aged 18 years of age and older with
2155:
1831:
658:
8:
120:
32:
229:In general: โ (Prescription only)
2162:
2148:
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380:
31:
600:Davidson JA, Sloan L (January 2017).
308:The most common side effects include
93:
7:
2112:
2110:
2049:Tooltip Sodium-glucose transporter 2
2040:Tooltip Sodium-glucose transporter 1
1904:Tooltip Sodium-glucose transporter 2
1863:Tooltip Sodium-glucose transporter 1
685:, and other drugs used in diabetes (
359:Canagliflozin ยง Adverse_effects
158:
1655:Glibenclamide (glyburide)/metformin
1635:Dapagliflozin/saxagliptin/metformin
270:
2216:Gastrointestinal system drug stubs
25:
530:from the original on 3 March 2020
495:from the original on 3 March 2020
410:from the original on 3 March 2020
2114:
2094:
577:
567:from the original on 7 June 2020
449:from the original on 7 June 2020
363:Metformin ยง Adverse_effects
1:
2075:Receptor/signaling modulators
2134:. You can help Knowledge by
1471:Alpha-glucosidase inhibitors
559:Food and Drug Administration
522:Food and Drug Administration
286:, sold under the brand name
2022:Antisense oligonucleotides:
1433:Aldose reductase inhibitors
341:Canagliflozin/metformin is
2232:
2186:Combination diabetes drugs
2109:
1847:Sodium-glucose transporter
1299:GLP1 poly-agonist peptides
356:
297:used for the treatment of
2068:
1745:Sitagliptin/ertugliflozin
1740:Sitagliptin/dapagliflozin
1660:Glimepiride/rosiglitazone
1640:Empagliflozin/linagliptin
1630:Dapagliflozin/saxagliptin
1605:
1158:Glibenclamide (glyburide)
914:
903:
711:
694:
618:10.1007/s12325-016-0434-2
487:European Medicines Agency
2126:article relating to the
1725:Pioglitazone/sitagliptin
1715:Pioglitazone/glimepiride
1705:Phenformin/sulfonylureas
1650:Gemigliptin/rosuvastatin
1620:Cagrilintide/semaglutide
322:vulvovaginal candidiasis
295:anti-diabetic medication
2128:gastrointestinal system
1755:Sitagliptin/simvastatin
1730:Rosiglitazone/metformin
1710:Pioglitazone/alogliptin
1700:Metformin/teneligliptin
1695:Metformin/sulfonylureas
1675:Metformin/ertugliflozin
1645:Empagliflozin/metformin
1625:Dapagliflozin/metformin
1615:Canagliflozin/metformin
1241:GLP-1 receptor agonists
284:Canagliflozin/metformin
34:Canagliflozin/metformin
1760:Vildagliptin/metformin
1720:Pioglitazone/metformin
292:fixed-dose combination
1750:Sitagliptin/metformin
1735:Saxagliptin/metformin
1690:Metformin/repaglinide
1685:Metformin/gemigliptin
1665:Linagliptin/metformin
1680:Metformin/evogliptin
1610:Alogliptin/metformin
526:. 4 September 2014.
491:. 18 February 2020.
406:. 13 February 2020.
79:Vokanamet, Invokamet
920:Insulin sensitizers
675:diabetes medication
445:. 5 February 2020.
290:among others, is a
205:(Prescription only)
36:
1799:Never to phase III
1670:Metformin/acarbose
1020:Dual PPAR agonists
889:Never to phase III
796:Ultralente insulin
2143:
2142:
2082:
2081:
1813:
1812:
1809:
1808:
1772:
1771:
1768:
1767:
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1591:
1420:
1419:
1332:
1331:
1235:
1234:
1078:
1077:
899:
898:
862:
861:
806:ultra-long-acting
730:Insulin glulisine
563:. 19 March 2020.
281:
280:
225:
213:
200:
188:
114:
16:(Redirected from
2223:
2206:SGLT2 inhibitors
2164:
2157:
2150:
2118:
2111:
2099:
2098:
2097:
2090:
2050:
2046:
2041:
2037:
1905:
1901:
1864:
1860:
1840:
1833:
1826:
1817:
1603:
1499:SGLT2 inhibitors
1429:
1338:DPP-4 inhibitors
1319:(GLP-1/GIP/GCGR)
1295:
1101:
1089:
925:
916:
905:
814:Insulin degludec
776:Insulin glargine
713:
696:
667:
660:
653:
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639:
629:
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581:
580:
576:
574:
572:
549:
540:
539:
537:
535:
512:
506:
504:
502:
500:
482:"Vokanamet EPAR"
478:
459:
458:
456:
454:
435:
420:
419:
417:
415:
396:
274:
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223:
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97:
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35:
21:
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1804:
1789:Clinical trials
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1328:
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1231:
1202:
1096:
1074:
1047:
1014:
959:/"glitazones" (
951:
910:
895:
894:
879:Clinical trials
858:
837:
818:+insulin aspart
800:
771:Insulin detemir
757:
753:Regular insulin
739:
707:
705:insulin analogs
690:
683:insulin analogs
671:
599:
596:
594:Further reading
591:
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398:
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377:
365:
355:
353:Adverse effects
347:type 2 diabetes
339:
299:type 2 diabetes
277:
257:
232:
166:
134:
127:
51:SGLT2 inhibitor
28:
23:
22:
15:
12:
11:
5:
2229:
2227:
2219:
2218:
2213:
2208:
2203:
2198:
2193:
2188:
2183:
2173:
2172:
2167:
2166:
2159:
2152:
2144:
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2140:
2119:
2104:
2103:
2080:
2079:
2069:
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2065:
2063:
2062:
2053:
2051:
2031:
2030:
2028:
2027:
2018:
2017:
2012:
2007:
2002:
1997:
1992:
1987:
1982:
1977:
1972:
1970:Luseogliflozin
1967:
1962:
1957:
1952:
1947:
1942:
1940:Enavogliflozin
1937:
1932:
1927:
1922:
1917:
1908:
1906:
1895:
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1533:Luseogliflozin
1530:
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1510:
1504:
1502:
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1201:
1200:
1198:Glyclopyramide
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1154:2nd generation
1150:
1149:
1144:
1139:
1134:
1129:
1127:Chlorpropamide
1124:
1119:
1113:1st generation
1109:
1107:
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1080:
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864:
863:
860:
859:
857:
856:
853:
849:
847:
839:
838:
836:
835:
828:Insulin icodec
825:
810:
808:
802:
801:
799:
798:
793:
788:
783:
773:
767:
765:
759:
758:
756:
755:
749:
747:
741:
740:
738:
737:
735:Insulin lispro
732:
727:
725:Insulin aspart
721:
719:
709:
708:
699:
692:
691:
672:
670:
669:
662:
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137:
135:administration
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105:
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98:
91:
81:
80:
77:
71:
70:
66:
65:
60:
54:
53:
48:
42:
41:
40:Combination of
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2228:
2217:
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2197:
2194:
2192:
2189:
2187:
2184:
2182:
2179:
2178:
2176:
2165:
2160:
2158:
2153:
2151:
2146:
2145:
2139:
2137:
2133:
2129:
2125:
2120:
2117:
2113:
2108:
2102:
2092:
2088:
2077:
2076:
2073:
2067:
2061:
2060:Sotagliflozin
2058:
2055:
2054:
2052:
2047:
2038:
2032:
2026:
2023:
2020:
2019:
2016:
2015:Velagliflozin
2013:
2011:
2010:Tofogliflozin
2008:
2006:
2003:
2001:
1998:
1996:
1993:
1991:
1990:Remogliflozin
1988:
1986:
1983:
1981:
1978:
1976:
1975:Mizagliflozin
1973:
1971:
1968:
1966:
1965:Licogliflozin
1963:
1961:
1960:Janagliflozin
1958:
1956:
1955:Ipragliflozin
1953:
1951:
1950:Henagliflozin
1948:
1946:
1945:Ertugliflozin
1943:
1941:
1938:
1936:
1935:Empagliflozin
1933:
1931:
1930:Dapagliflozin
1928:
1926:
1925:Canagliflozin
1923:
1921:
1920:Bexagliflozin
1918:
1916:
1913:
1910:
1909:
1907:
1902:
1896:
1890:
1887:
1885:
1882:
1880:
1877:
1875:
1872:
1869:
1868:
1866:
1861:
1855:
1851:
1848:
1841:
1836:
1834:
1829:
1827:
1822:
1821:
1818:
1798:
1796:
1793:
1792:
1790:
1787:
1784:
1781:
1779:
1776:
1775:
1761:
1758:
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1753:
1751:
1748:
1746:
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1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1708:
1706:
1703:
1701:
1698:
1696:
1693:
1691:
1688:
1686:
1683:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
1653:
1651:
1648:
1646:
1643:
1641:
1638:
1636:
1633:
1631:
1628:
1626:
1623:
1621:
1618:
1616:
1613:
1611:
1608:
1607:
1604:
1601:
1599:
1595:
1585:
1582:
1580:
1579:Bromocriptine
1577:
1575:
1572:
1571:
1569:
1565:
1559:
1558:Velagliflozin
1556:
1554:
1553:Tofogliflozin
1551:
1549:
1548:Sotagliflozin
1546:
1544:
1541:
1539:
1538:Remogliflozin
1536:
1534:
1531:
1529:
1528:Ipragliflozin
1526:
1524:
1523:Ertugliflozin
1521:
1519:
1518:Empagliflozin
1516:
1514:
1513:Dapagliflozin
1511:
1509:
1508:Canagliflozin
1506:
1505:
1503:
1501:/"gliflozins"
1500:
1496:
1490:
1487:
1485:
1482:
1480:
1477:
1476:
1474:
1472:
1468:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
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988:
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69:Clinical data
67:
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46:Canagliflozin
43:
38:
30:
19:
2191:Fluoroarenes
2136:expanding it
2121:
2106:
2071:
2070:
2056:
2021:
1995:Sergliflozin
1915:Atigliflozin
1911:
1870:
1614:
1598:Combinations
1543:Sergliflozin
1412:Vildagliptin
1407:Trelagliptin
1387:Omarigliptin
1362:Garvagliptin
1289:Taspoglutide
1279:Orforglipron
1274:Lixisenatide
1208:Meglitinides
1163:Glibornuride
1153:
1137:Metahexamide
1132:Glycyclamide
1112:
1065:Cagrilintide
1055:analogs and
1043:Tesaglitazar
1038:Saroglitazar
1033:Muraglitazar
1010:Troglitazone
995:Pioglitazone
975:Darglitazone
909:Non-insulins
842:
832:+semaglutide
822:+liraglutide
805:
762:
745:short-acting
744:
716:
612:(1): 41โ59.
609:
605:
569:. Retrieved
556:
532:. Retrieved
519:
510:
497:. Retrieved
485:
451:. Retrieved
442:
412:. Retrieved
403:
370:
366:
340:
337:Medical uses
332:
325:
310:hypoglycemia
307:
287:
283:
282:
252:2131792-63-5
177:Legal status
171:Legal status
103:License data
29:
2057:Inhibitors:
2025:ISIS-388626
1912:Inhibitors:
1871:Inhibitors:
1785:from market
1397:Sitagliptin
1392:Saxagliptin
1382:Melogliptin
1377:Linagliptin
1372:Gosogliptin
1367:Gemigliptin
1340:/"gliptins"
1325:(GLP-1/GIP)
1323:Tirzepatide
1317:Retatrutide
1284:Semaglutide
1269:Liraglutide
1259:Dulaglutide
1254:Danuglipron
1249:Albiglutide
1227:Repaglinide
1222:Nateglinide
1217:Mitiglinide
1210:/"glinides"
1193:Glisoxepide
1178:Glimepiride
1168:Glicaramide
1147:Tolbutamide
1122:Carbutamide
1070:Pramlintide
1028:Aleglitazar
980:Englitazone
970:Ciglitazone
875:from market
786:NPH insulin
763:long-acting
717:fast-acting
237:Identifiers
75:Trade names
2211:Thiophenes
2201:Guanidines
2196:Glucosides
2181:Biguanides
2175:Categories
1850:modulators
1574:Benfluorex
1461:Zenarestat
1451:Ranirestat
1446:Fidarestat
1441:Epalrestat
1357:Evogliptin
1352:Anagliptin
1347:Alogliptin
1188:Gliquidone
1173:Gliclazide
1142:Tolazamide
947:Phenformin
929:Biguanides
375:References
357:See also:
243:CAS Number
2072:See also:
1985:Phlorizin
1980:Phloretin
1879:Phlorizin
1874:Phloretin
1795:Phase III
1783:Withdrawn
1584:Imeglimin
1489:Voglibose
1456:Tolrestat
1307:Mazdutide
1264:Exenatide
1183:Glipizide
942:Metformin
885:Phase III
873:Withdrawn
844:inhalable
343:indicated
288:Vokanamet
133:Routes of
122:Invokamet
95:Monograph
89:Drugs.com
63:Biguanide
58:Metformin
18:Invokamet
2101:Medicine
1484:Miglitol
1479:Acarbose
937:Buformin
701:Insulins
679:insulins
636:27854055
606:Adv Ther
565:Archived
528:Archived
493:Archived
447:Archived
443:DailyMed
408:Archived
303:by mouth
147:ATC code
140:By mouth
117:DailyMed
2005:T-1095A
1889:T-1095A
1309:(GLP-1/
855:Afrezza
852:Exubera
627:5216068
534:2 March
499:2 March
453:2 March
414:2 March
327:Candida
314:insulin
189::
163:)
157: (
155:A10BD16
119::
2087:Portal
2042:&
2000:T-1095
1884:T-1095
1778:WHO-EM
1057:DACRAs
1053:Amylin
868:WHO-EM
634:
624:
571:6 June
361:, and
272:D10587
216:โ-only
214:
201:
191:โ-only
115:
2130:is a
2122:This
2045:SGLT2
2036:SGLT1
1900:SGLT2
1859:SGLT1
1567:Other
1425:Other
673:Oral
561:(FDA)
557:U.S.
524:(FDA)
520:U.S.
489:(EMA)
404:(emc)
316:or a
2132:stub
2124:drug
1311:GCGR
961:PPAR
957:TZDs
681:and
632:PMID
573:2020
536:2020
501:2020
455:2020
416:2020
320:and
263:KEGG
85:AHFS
1095:ATP
687:A10
622:PMC
614:doi
330:).
203:POM
160:WHO
2177::
1791::
1156::
1115::
881::
820:,
677:,
630:.
620:.
610:34
608:.
604:.
555:.
544:^
518:.
484:.
463:^
441:.
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402:.
383:^
305:.
222:EU
210:US
197:UK
186:CA
112:US
2163:e
2156:t
2149:v
2138:.
2089::
1839:e
1832:t
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1093:K
963:)
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659:t
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638:.
616::
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538:.
503:.
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418:.
224::
212::
199::
87:/
20:)
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