Knowledge

Canagliflozin/metformin

Source ๐Ÿ“

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To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before
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scheduled surgery. Canagliflozin, dapagliflozin, and empagliflozin should each be stopped at least three days before, and ertugliflozin should be stopped at least four days before scheduled surgery.
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Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
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Canagliflozin/metformin was approved for medical use in the European Union in April 2014, and for use in the United States in August 2014.
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Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing.
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This article incorporates text from this source, which is in the
324:(thrush, a fungal infection of the female genital area caused by 349:
as an adjunct to diet and exercise to improve glycemic control.
301:. It is used in combination with diet and exercise. It is taken 262: 221: 196: 1819: 907: 698: 646: 209: 111: 547: 545: 312:(low blood glucose levels) when used in combination with 185: 2135: 2084: 433: 431: 429: 427: 425: 2044: 2035: 1899: 1858: 2033: 1897: 1856: 1596: 1566: 1497: 1469: 1431: 1424: 1336: 1297: 1239: 1206: 1103: 1091: 1082: 1051: 1018: 955: 927: 918: 841: 804: 761: 743: 715: 261: 241: 236: 175: 170: 145: 131: 101: 83: 73: 68: 56: 44: 39: 476: 474: 472: 470: 468: 466: 464: 394: 392: 390: 388: 386: 384: 250: 27:Fixed-dose combination anti-diabetic medication 345:in adults aged 18 years of age and older with 2155: 1831: 658: 8: 120: 32: 229:In general: โ„ž (Prescription only) 2162: 2148: 1838: 1824: 1816: 1602: 1428: 1294: 1100: 1088: 924: 915: 904: 712: 695: 665: 651: 643: 625: 2091: 380: 31: 600:Davidson JA, Sloan L (January 2017). 308:The most common side effects include 93: 7: 2112: 2110: 2049:Tooltip Sodium-glucose transporter 2 2040:Tooltip Sodium-glucose transporter 1 1904:Tooltip Sodium-glucose transporter 2 1863:Tooltip Sodium-glucose transporter 1 685:, and other drugs used in diabetes ( 359:Canagliflozin ยง Adverse_effects 158: 1655:Glibenclamide (glyburide)/metformin 1635:Dapagliflozin/saxagliptin/metformin 270: 2216:Gastrointestinal system drug stubs 25: 530:from the original on 3 March 2020 495:from the original on 3 March 2020 410:from the original on 3 March 2020 2114: 2094: 577: 567:from the original on 7 June 2020 449:from the original on 7 June 2020 363:Metformin ยง Adverse_effects 1: 2075:Receptor/signaling modulators 2134:. You can help Knowledge by 1471:Alpha-glucosidase inhibitors 559:Food and Drug Administration 522:Food and Drug Administration 286:, sold under the brand name 2022:Antisense oligonucleotides: 1433:Aldose reductase inhibitors 341:Canagliflozin/metformin is 2232: 2186:Combination diabetes drugs 2109: 1847:Sodium-glucose transporter 1299:GLP1 poly-agonist peptides 356: 297:used for the treatment of 2068: 1745:Sitagliptin/ertugliflozin 1740:Sitagliptin/dapagliflozin 1660:Glimepiride/rosiglitazone 1640:Empagliflozin/linagliptin 1630:Dapagliflozin/saxagliptin 1605: 1158:Glibenclamide (glyburide) 914: 903: 711: 694: 618:10.1007/s12325-016-0434-2 487:European Medicines Agency 2126:article relating to the 1725:Pioglitazone/sitagliptin 1715:Pioglitazone/glimepiride 1705:Phenformin/sulfonylureas 1650:Gemigliptin/rosuvastatin 1620:Cagrilintide/semaglutide 322:vulvovaginal candidiasis 295:anti-diabetic medication 2128:gastrointestinal system 1755:Sitagliptin/simvastatin 1730:Rosiglitazone/metformin 1710:Pioglitazone/alogliptin 1700:Metformin/teneligliptin 1695:Metformin/sulfonylureas 1675:Metformin/ertugliflozin 1645:Empagliflozin/metformin 1625:Dapagliflozin/metformin 1615:Canagliflozin/metformin 1241:GLP-1 receptor agonists 284:Canagliflozin/metformin 34:Canagliflozin/metformin 1760:Vildagliptin/metformin 1720:Pioglitazone/metformin 292:fixed-dose combination 1750:Sitagliptin/metformin 1735:Saxagliptin/metformin 1690:Metformin/repaglinide 1685:Metformin/gemigliptin 1665:Linagliptin/metformin 1680:Metformin/evogliptin 1610:Alogliptin/metformin 526:. 4 September 2014. 491:. 18 February 2020. 406:. 13 February 2020. 79:Vokanamet, Invokamet 920:Insulin sensitizers 675:diabetes medication 445:. 5 February 2020. 290:among others, is a 205:(Prescription only) 36: 1799:Never to phase III 1670:Metformin/acarbose 1020:Dual PPAR agonists 889:Never to phase III 796:Ultralente insulin 2143: 2142: 2082: 2081: 1813: 1812: 1809: 1808: 1772: 1771: 1768: 1767: 1592: 1591: 1420: 1419: 1332: 1331: 1235: 1234: 1078: 1077: 899: 898: 862: 861: 806:ultra-long-acting 730:Insulin glulisine 563:. 19 March 2020. 281: 280: 225: 213: 200: 188: 114: 16:(Redirected from 2223: 2206:SGLT2 inhibitors 2164: 2157: 2150: 2118: 2111: 2099: 2098: 2097: 2090: 2050: 2046: 2041: 2037: 1905: 1901: 1864: 1860: 1840: 1833: 1826: 1817: 1603: 1499:SGLT2 inhibitors 1429: 1338:DPP-4 inhibitors 1319:(GLP-1/GIP/GCGR) 1295: 1101: 1089: 925: 916: 905: 814:Insulin degludec 776:Insulin glargine 713: 696: 667: 660: 653: 644: 639: 629: 587: 581: 580: 576: 574: 572: 549: 540: 539: 537: 535: 512: 506: 504: 502: 500: 482:"Vokanamet EPAR" 478: 459: 458: 456: 454: 435: 420: 419: 417: 415: 396: 274: 254: 223: 220: 211: 208: 198: 195: 187: 184: 162: 124: 113: 110: 97: 37: 35: 21: 2231: 2230: 2226: 2225: 2224: 2222: 2221: 2220: 2171: 2170: 2169: 2168: 2107: 2105: 2095: 2093: 2085: 2083: 2078: 2064: 2048: 2039: 2029: 1903: 1893: 1862: 1852: 1844: 1814: 1805: 1804: 1789:Clinical trials 1764: 1588: 1562: 1493: 1465: 1416: 1328: 1293: 1231: 1202: 1096: 1074: 1047: 1014: 959:/"glitazones" ( 951: 910: 895: 894: 879:Clinical trials 858: 837: 818:+insulin aspart 800: 771:Insulin detemir 757: 753:Regular insulin 739: 707: 705:insulin analogs 690: 683:insulin analogs 671: 599: 596: 594:Further reading 591: 590: 578: 570: 568: 551: 550: 543: 533: 531: 514: 513: 509: 498: 496: 480: 479: 462: 452: 450: 437: 436: 423: 413: 411: 398: 397: 382: 377: 365: 355: 353:Adverse effects 347:type 2 diabetes 339: 299:type 2 diabetes 277: 257: 232: 166: 134: 127: 51:SGLT2 inhibitor 28: 23: 22: 15: 12: 11: 5: 2229: 2227: 2219: 2218: 2213: 2208: 2203: 2198: 2193: 2188: 2183: 2173: 2172: 2167: 2166: 2159: 2152: 2144: 2141: 2140: 2119: 2104: 2103: 2080: 2079: 2069: 2066: 2065: 2063: 2062: 2053: 2051: 2031: 2030: 2028: 2027: 2018: 2017: 2012: 2007: 2002: 1997: 1992: 1987: 1982: 1977: 1972: 1970:Luseogliflozin 1967: 1962: 1957: 1952: 1947: 1942: 1940:Enavogliflozin 1937: 1932: 1927: 1922: 1917: 1908: 1906: 1895: 1894: 1892: 1891: 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1203: 1201: 1200: 1198:Glyclopyramide 1195: 1190: 1185: 1180: 1175: 1170: 1165: 1160: 1154:2nd generation 1150: 1149: 1144: 1139: 1134: 1129: 1127:Chlorpropamide 1124: 1119: 1113:1st generation 1109: 1107: 1098: 1094: 1086: 1080: 1079: 1076: 1075: 1073: 1072: 1067: 1061: 1059: 1049: 1048: 1046: 1045: 1040: 1035: 1030: 1024: 1022: 1016: 1015: 1013: 1012: 1007: 1002: 997: 992: 987: 982: 977: 972: 966: 964: 953: 952: 950: 949: 944: 939: 933: 931: 922: 912: 911: 908: 901: 900: 897: 896: 893: 892: 891: 890: 887: 876: 870: 864: 863: 860: 859: 857: 856: 853: 849: 847: 839: 838: 836: 835: 828:Insulin icodec 825: 810: 808: 802: 801: 799: 798: 793: 788: 783: 773: 767: 765: 759: 758: 756: 755: 749: 747: 741: 740: 738: 737: 735:Insulin lispro 732: 727: 725:Insulin aspart 721: 719: 709: 708: 699: 692: 691: 672: 670: 669: 662: 655: 647: 641: 640: 595: 592: 589: 588: 541: 507: 460: 421: 379: 378: 376: 373: 354: 351: 338: 335: 279: 278: 276: 275: 267: 265: 259: 258: 256: 255: 247: 245: 239: 238: 234: 233: 231: 230: 227: 218: 206: 193: 181: 179: 173: 172: 168: 167: 165: 164: 151: 149: 143: 142: 137: 135:administration 129: 128: 126: 125: 107: 105: 99: 98: 91: 81: 80: 77: 71: 70: 66: 65: 60: 54: 53: 48: 42: 41: 40:Combination of 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 2228: 2217: 2214: 2212: 2209: 2207: 2204: 2202: 2199: 2197: 2194: 2192: 2189: 2187: 2184: 2182: 2179: 2178: 2176: 2165: 2160: 2158: 2153: 2151: 2146: 2145: 2139: 2137: 2133: 2129: 2125: 2120: 2117: 2113: 2108: 2102: 2092: 2088: 2077: 2076: 2073: 2067: 2061: 2060:Sotagliflozin 2058: 2055: 2054: 2052: 2047: 2038: 2032: 2026: 2023: 2020: 2019: 2016: 2015:Velagliflozin 2013: 2011: 2010:Tofogliflozin 2008: 2006: 2003: 2001: 1998: 1996: 1993: 1991: 1990:Remogliflozin 1988: 1986: 1983: 1981: 1978: 1976: 1975:Mizagliflozin 1973: 1971: 1968: 1966: 1965:Licogliflozin 1963: 1961: 1960:Janagliflozin 1958: 1956: 1955:Ipragliflozin 1953: 1951: 1950:Henagliflozin 1948: 1946: 1945:Ertugliflozin 1943: 1941: 1938: 1936: 1935:Empagliflozin 1933: 1931: 1930:Dapagliflozin 1928: 1926: 1925:Canagliflozin 1923: 1921: 1920:Bexagliflozin 1918: 1916: 1913: 1910: 1909: 1907: 1902: 1896: 1890: 1887: 1885: 1882: 1880: 1877: 1875: 1872: 1869: 1868: 1866: 1861: 1855: 1851: 1848: 1841: 1836: 1834: 1829: 1827: 1822: 1821: 1818: 1798: 1796: 1793: 1792: 1790: 1787: 1784: 1781: 1779: 1776: 1775: 1761: 1758: 1756: 1753: 1751: 1748: 1746: 1743: 1741: 1738: 1736: 1733: 1731: 1728: 1726: 1723: 1721: 1718: 1716: 1713: 1711: 1708: 1706: 1703: 1701: 1698: 1696: 1693: 1691: 1688: 1686: 1683: 1681: 1678: 1676: 1673: 1671: 1668: 1666: 1663: 1661: 1658: 1656: 1653: 1651: 1648: 1646: 1643: 1641: 1638: 1636: 1633: 1631: 1628: 1626: 1623: 1621: 1618: 1616: 1613: 1611: 1608: 1607: 1604: 1601: 1599: 1595: 1585: 1582: 1580: 1579:Bromocriptine 1577: 1575: 1572: 1571: 1569: 1565: 1559: 1558:Velagliflozin 1556: 1554: 1553:Tofogliflozin 1551: 1549: 1548:Sotagliflozin 1546: 1544: 1541: 1539: 1538:Remogliflozin 1536: 1534: 1531: 1529: 1528:Ipragliflozin 1526: 1524: 1523:Ertugliflozin 1521: 1519: 1518:Empagliflozin 1516: 1514: 1513:Dapagliflozin 1511: 1509: 1508:Canagliflozin 1506: 1505: 1503: 1501:/"gliflozins" 1500: 1496: 1490: 1487: 1485: 1482: 1480: 1477: 1476: 1474: 1472: 1468: 1462: 1459: 1457: 1454: 1452: 1449: 1447: 1444: 1442: 1439: 1438: 1436: 1434: 1430: 1427: 1423: 1413: 1410: 1408: 1405: 1403: 1402:Teneligliptin 1400: 1398: 1395: 1393: 1390: 1388: 1385: 1383: 1380: 1378: 1375: 1373: 1370: 1368: 1365: 1363: 1360: 1358: 1355: 1353: 1350: 1348: 1345: 1344: 1342: 1339: 1335: 1324: 1321: 1318: 1315: 1312: 1308: 1305: 1304: 1302: 1300: 1296: 1290: 1287: 1285: 1282: 1280: 1277: 1275: 1272: 1270: 1267: 1265: 1262: 1260: 1257: 1255: 1252: 1250: 1247: 1246: 1244: 1242: 1238: 1228: 1225: 1223: 1220: 1218: 1215: 1214: 1212: 1209: 1205: 1199: 1196: 1194: 1191: 1189: 1186: 1184: 1181: 1179: 1176: 1174: 1171: 1169: 1166: 1164: 1161: 1159: 1155: 1152: 1151: 1148: 1145: 1143: 1140: 1138: 1135: 1133: 1130: 1128: 1125: 1123: 1120: 1118: 1117:Acetohexamide 1114: 1111: 1110: 1108: 1106: 1105:Sulfonylureas 1102: 1099: 1097: 1090: 1087: 1085: 1084:Secretagogues 1081: 1071: 1068: 1066: 1063: 1062: 1060: 1058: 1054: 1050: 1044: 1041: 1039: 1036: 1034: 1031: 1029: 1026: 1025: 1023: 1021: 1017: 1011: 1008: 1006: 1005:Rosiglitazone 1003: 1001: 1000:Rivoglitazone 998: 996: 993: 991: 990:Netoglitazone 988: 986: 985:Lobeglitazone 983: 981: 978: 976: 973: 971: 968: 967: 965: 962: 958: 954: 948: 945: 943: 940: 938: 935: 934: 932: 930: 926: 923: 921: 917: 913: 906: 902: 888: 886: 883: 882: 880: 877: 874: 871: 869: 866: 865: 854: 851: 850: 848: 846: 845: 840: 833: 829: 826: 823: 819: 815: 812: 811: 809: 807: 803: 797: 794: 792: 791:Lente insulin 789: 787: 784: 781: 780:+lixisenatide 777: 774: 772: 769: 768: 766: 764: 760: 754: 751: 750: 748: 746: 742: 736: 733: 731: 728: 726: 723: 722: 720: 718: 714: 710: 706: 702: 697: 693: 688: 684: 680: 676: 668: 663: 661: 656: 654: 649: 648: 645: 637: 633: 628: 623: 619: 615: 611: 607: 603: 598: 597: 593: 585: 584:public domain 566: 562: 560: 554: 548: 546: 542: 529: 525: 523: 517: 511: 508: 494: 490: 488: 483: 477: 475: 473: 471: 469: 467: 465: 461: 448: 444: 440: 434: 432: 430: 428: 426: 422: 409: 405: 401: 395: 393: 391: 389: 387: 385: 381: 374: 372: 369: 364: 360: 352: 350: 348: 344: 336: 334: 331: 329: 328: 323: 319: 318:sulphonylurea 315: 311: 306: 304: 300: 296: 293: 289: 285: 273: 269: 268: 266: 264: 260: 253: 249: 248: 246: 244: 240: 235: 228: 226: Rx-only 219: 217: 207: 204: 194: 192: 183: 182: 180: 178: 174: 169: 161: 156: 153: 152: 150: 148: 144: 141: 138: 136: 130: 123: 118: 109: 108: 106: 104: 100: 96: 92: 90: 86: 82: 78: 76: 72: 69:Clinical data 67: 64: 61: 59: 55: 52: 49: 47: 46:Canagliflozin 43: 38: 30: 19: 2191:Fluoroarenes 2136:expanding it 2121: 2106: 2071: 2070: 2056: 2021: 1995:Sergliflozin 1915:Atigliflozin 1911: 1870: 1614: 1598:Combinations 1543:Sergliflozin 1412:Vildagliptin 1407:Trelagliptin 1387:Omarigliptin 1362:Garvagliptin 1289:Taspoglutide 1279:Orforglipron 1274:Lixisenatide 1208:Meglitinides 1163:Glibornuride 1153: 1137:Metahexamide 1132:Glycyclamide 1112: 1065:Cagrilintide 1055:analogs and 1043:Tesaglitazar 1038:Saroglitazar 1033:Muraglitazar 1010:Troglitazone 995:Pioglitazone 975:Darglitazone 909:Non-insulins 842: 832:+semaglutide 822:+liraglutide 805: 762: 745:short-acting 744: 716: 612:(1): 41โ€“59. 609: 605: 569:. Retrieved 556: 532:. Retrieved 519: 510: 497:. Retrieved 485: 451:. Retrieved 442: 412:. Retrieved 403: 370: 366: 340: 337:Medical uses 332: 325: 310:hypoglycemia 307: 287: 283: 282: 252:2131792-63-5 177:Legal status 171:Legal status 103:License data 29: 2057:Inhibitors: 2025:ISIS-388626 1912:Inhibitors: 1871:Inhibitors: 1785:from market 1397:Sitagliptin 1392:Saxagliptin 1382:Melogliptin 1377:Linagliptin 1372:Gosogliptin 1367:Gemigliptin 1340:/"gliptins" 1325:(GLP-1/GIP) 1323:Tirzepatide 1317:Retatrutide 1284:Semaglutide 1269:Liraglutide 1259:Dulaglutide 1254:Danuglipron 1249:Albiglutide 1227:Repaglinide 1222:Nateglinide 1217:Mitiglinide 1210:/"glinides" 1193:Glisoxepide 1178:Glimepiride 1168:Glicaramide 1147:Tolbutamide 1122:Carbutamide 1070:Pramlintide 1028:Aleglitazar 980:Englitazone 970:Ciglitazone 875:from market 786:NPH insulin 763:long-acting 717:fast-acting 237:Identifiers 75:Trade names 2211:Thiophenes 2201:Guanidines 2196:Glucosides 2181:Biguanides 2175:Categories 1850:modulators 1574:Benfluorex 1461:Zenarestat 1451:Ranirestat 1446:Fidarestat 1441:Epalrestat 1357:Evogliptin 1352:Anagliptin 1347:Alogliptin 1188:Gliquidone 1173:Gliclazide 1142:Tolazamide 947:Phenformin 929:Biguanides 375:References 357:See also: 243:CAS Number 2072:See also: 1985:Phlorizin 1980:Phloretin 1879:Phlorizin 1874:Phloretin 1795:Phase III 1783:Withdrawn 1584:Imeglimin 1489:Voglibose 1456:Tolrestat 1307:Mazdutide 1264:Exenatide 1183:Glipizide 942:Metformin 885:Phase III 873:Withdrawn 844:inhalable 343:indicated 288:Vokanamet 133:Routes of 122:Invokamet 95:Monograph 89:Drugs.com 63:Biguanide 58:Metformin 18:Invokamet 2101:Medicine 1484:Miglitol 1479:Acarbose 937:Buformin 701:Insulins 679:insulins 636:27854055 606:Adv Ther 565:Archived 528:Archived 493:Archived 447:Archived 443:DailyMed 408:Archived 303:by mouth 147:ATC code 140:By mouth 117:DailyMed 2005:T-1095A 1889:T-1095A 1309:(GLP-1/ 855:Afrezza 852:Exubera 627:5216068 534:2 March 499:2 March 453:2 March 414:2 March 327:Candida 314:insulin 189:: 163:) 157: ( 155:A10BD16 119::  2087:Portal 2042:& 2000:T-1095 1884:T-1095 1778:WHO-EM 1057:DACRAs 1053:Amylin 868:WHO-EM 634:  624:  571:6 June 361:, and 272:D10587 216:โ„ž-only 214: 201: 191:โ„ž-only 115:  2130:is a 2122:This 2045:SGLT2 2036:SGLT1 1900:SGLT2 1859:SGLT1 1567:Other 1425:Other 673:Oral 561:(FDA) 557:U.S. 524:(FDA) 520:U.S. 489:(EMA) 404:(emc) 316:or a 2132:stub 2124:drug 1311:GCGR 961:PPAR 957:TZDs 681:and 632:PMID 573:2020 536:2020 501:2020 455:2020 416:2020 320:and 263:KEGG 85:AHFS 1095:ATP 687:A10 622:PMC 614:doi 330:). 203:POM 160:WHO 2177:: 1791:: 1156:: 1115:: 881:: 820:, 677:, 630:. 620:. 610:34 608:. 604:. 555:. 544:^ 518:. 484:. 463:^ 441:. 424:^ 402:. 383:^ 305:. 222:EU 210:US 197:UK 186:CA 112:US 2163:e 2156:t 2149:v 2138:. 2089:: 1839:e 1832:t 1825:v 1313:) 1093:K 963:) 834:) 830:( 824:) 816:( 782:) 778:( 703:/ 689:) 666:e 659:t 652:v 638:. 616:: 586:. 575:. 538:. 503:. 457:. 418:. 224:: 212:: 199:: 87:/ 20:)

Index

Invokamet
Canagliflozin
SGLT2 inhibitor
Metformin
Biguanide
Trade names
AHFS
Drugs.com
Monograph
License data
DailyMed
Invokamet
Routes of
administration

By mouth
ATC code
A10BD16
WHO
Legal status
โ„ž-only
POM
โ„ž-only
CAS Number
2131792-63-5
KEGG
D10587
fixed-dose combination
anti-diabetic medication
type 2 diabetes
by mouth
hypoglycemia

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