175:
29:
583:
Eichenbaum G, Zhou J, Kelley MF, Roosen W, Costa-Giomi P, Louden C, et al. (July 2014). "Implications of retinal effects observed in chronic toxicity studies on the clinical development of a CNS-active drug candidate".
428:
Di
Prospero NA, Gambale JJ, Pandina G, Ford L, Girgis S, Moyer JA, et al. (May 2014). "Evaluation of JNJ-26489112 in patients with photosensitive epilepsy: a placebo-controlled, exploratory study".
477:"Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)"
1329:
268:
542:
Zaccara G, Schmidt D (February 2016). "Do traditional anti-seizure drugs have a future? A review of potential anti-seizure drugs in clinical development".
254:
415:
for "A Study of the
Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram Response in Patients With Photosensitive Epilepsy" at
635:
341:. This clinical trial was terminated in 2013 due to a "sponsor portfolio decision", and no new development of JNJ-26489112 has been reported.
1319:
1270:
288:
44:
628:
1157:
134:
1287:
818:
154:
529:
for "A Safety and
Efficacy Study of JNJ26489112 in Patients With Treatment-Resistant Major Depressive Disorder" at
338:
1344:
1314:
1128:
621:
475:
McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, et al. (November 2013).
378:
296:
InChI=1S/C9H11ClN2O4S/c10-6-1-2-8-9(3-6)15-5-7(16-8)4-12-17(11,13)14/h1-3,7,12H,4-5H2,(H2,11,13,14)/t7-/m0/s1
1275:
1037:
995:
874:
1166:
904:
1339:
1324:
864:
377:
Trenité DK, Diprospero NA, Moyer JA, Gambale J, Pandina G, Ford L, Girgis S, Xi L, Nye J (August 2013).
943:
1046:
673:
319:
170:
1334:
697:
345:
69:
530:
454:
416:
379:"Evaluation of JNJ-26489112, a Novel Antiepileptic Drug: A Placebo-Controlled, Exploratory Study"
331:
978:
893:
842:
788:
601:
559:
506:
446:
330:. It is expected to have fewer side effects than topiramate because it lacks activity against
123:
948:
593:
551:
496:
488:
438:
390:
191:
78:
143:
174:
1281:
1056:
792:
732:
666:
644:
501:
476:
315:
1308:
1247:
1176:
1171:
1086:
1061:
1000:
990:
707:
702:
442:
103:
458:
395:
1237:
1217:
1081:
1071:
923:
687:
648:
357:
525:
411:
1227:
1222:
1108:
1066:
1012:
983:
958:
953:
928:
808:
803:
767:
747:
692:
682:
597:
555:
1252:
1242:
1232:
1191:
1186:
1136:
1118:
1113:
1096:
1091:
1076:
1027:
1022:
1017:
1007:
973:
963:
847:
837:
827:
772:
742:
722:
327:
230:
114:
20:
1212:
1103:
1051:
968:
933:
913:
879:
869:
832:
798:
777:
762:
757:
727:
717:
712:
657:
605:
563:
510:
450:
28:
1207:
1181:
938:
918:
752:
737:
323:
613:
784:
89:
492:
253:
244:
617:
159:
1200:
1156:
1149:
1127:
1036:
903:
892:
856:
817:
665:
656:
242:
229:
190:
185:
153:
133:
113:
88:
68:
35:
102:
326:. JNJ-26489112 was designed as a successor to
77:
629:
8:
337:JNJ-26489112 was studied as a treatment for
19:
1153:
900:
662:
636:
622:
614:
470:
468:
173:
122:
27:
500:
394:
142:
1330:Drugs developed by Johnson & Johnson
369:
293:
273:
169:
49:
586:Regulatory Toxicology and Pharmacology
581:Toxicological study of JNJ-26489112:
18:
7:
93:
276:NS(=O)(=O)NC1COC2=C(O1)C=CC(Cl)=C2
14:
443:10.1016/j.eplepsyres.2014.01.018
211:
208:
202:
396:10.1016/j.clinthera.2013.07.204
301:Key:KXSAIQPPGSSNKX-ZETCQYMHSA-N
481:Journal of Medicinal Chemistry
223:
217:
196:
1:
60:-dioxin-2-yl)methyl]sulfamide
1320:Experimental antidepressants
598:10.1016/j.yrtph.2014.03.005
1361:
556:10.1016/j.phrs.2015.12.011
186:Chemical and physical data
1265:
339:major depressive disorder
284:
264:
40:
26:
544:Pharmacological Research
318:drug being developed by
996:Eslicarbazepine acetate
523:Clinical trial number
409:Clinical trial number
383:Clinical Therapeutics
322:for the treatment of
320:Johnson & Johnson
698:Methylphenobarbital
346:mechanism of action
23:
1292:Never to phase III
531:ClinicalTrials.gov
417:ClinicalTrials.gov
332:carbonic anhydrase
1302:
1301:
1261:
1260:
1145:
1144:
1129:Potassium openers
1047:Oxazolidinediones
979:Valproate pivoxil
944:Acetylpheneturide
888:
887:
843:Valproate pivoxil
819:GABA-T inhibitors
789:potassium bromide
493:10.1021/jm400894u
431:Epilepsy Research
309:
308:
255:Interactive image
155:CompTox Dashboard
16:Chemical compound
1352:
1154:
1038:Calcium blockers
949:Chlorphenacemide
901:
875:GAT-1 inhibitors
663:
638:
631:
624:
615:
609:
568:
567:
539:
533:
521:
515:
514:
504:
472:
463:
462:
425:
419:
407:
401:
400:
398:
374:
257:
237:
225:
219:
213:
210:
204:
198:
178:
177:
163:
161:
146:
126:
106:
96:
95:
81:
31:
24:
22:
1360:
1359:
1355:
1354:
1353:
1351:
1350:
1349:
1345:Abandoned drugs
1315:Anticonvulsants
1305:
1304:
1303:
1298:
1297:
1282:Clinical trials
1257:
1196:
1141:
1123:
1032:
905:Sodium blockers
895:
884:
852:
813:
733:Benzodiazepines
670:
652:
645:Anticonvulsants
642:
612:
582:
577:
575:Further reading
572:
571:
541:
540:
536:
522:
518:
487:(22): 9019–30.
474:
473:
466:
427:
426:
422:
408:
404:
376:
375:
371:
366:
354:
305:
302:
297:
292:
291:
280:
277:
272:
271:
260:
235:
222:
216:
207:
201:
181:
171:DTXSID601031470
157:
149:
129:
109:
92:
84:
64:
61:
48:
47:
17:
12:
11:
5:
1358:
1356:
1348:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1307:
1306:
1300:
1299:
1296:
1295:
1294:
1293:
1290:
1279:
1273:
1267:
1266:
1263:
1262:
1259:
1258:
1256:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1204:
1202:
1198:
1197:
1195:
1194:
1189:
1184:
1179:
1174:
1162:
1160:
1151:
1147:
1146:
1143:
1142:
1140:
1139:
1133:
1131:
1125:
1124:
1122:
1121:
1116:
1111:
1106:
1094:
1087:Gabapentinoids
1079:
1074:
1059:
1057:Paramethadione
1054:
1042:
1040:
1034:
1033:
1031:
1030:
1025:
1020:
1015:
1010:
998:
993:
988:
976:
971:
956:
951:
946:
931:
926:
921:
909:
907:
898:
890:
889:
886:
885:
883:
882:
865:GABAR agonists
860:
858:
854:
853:
851:
850:
845:
840:
835:
830:(and related):
823:
821:
815:
814:
812:
811:
806:
801:
796:
793:sodium bromide
775:
770:
765:
760:
755:
750:
745:
740:
725:
710:
705:
700:
695:
690:
678:
676:
668:
660:
654:
653:
643:
641:
640:
633:
626:
618:
611:
610:
592:(2): 187–200.
578:
576:
573:
570:
569:
534:
516:
464:
420:
402:
368:
367:
365:
362:
361:
360:
353:
350:
316:anticonvulsant
307:
306:
304:
303:
300:
298:
295:
287:
286:
285:
282:
281:
279:
278:
275:
267:
266:
265:
262:
261:
259:
258:
250:
248:
240:
239:
233:
227:
226:
220:
214:
205:
199:
194:
188:
187:
183:
182:
180:
179:
166:
164:
151:
150:
148:
147:
139:
137:
131:
130:
128:
127:
119:
117:
111:
110:
108:
107:
99:
97:
86:
85:
83:
82:
74:
72:
66:
65:
63:
62:
51:
43:
42:
41:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
1357:
1346:
1343:
1341:
1338:
1336:
1333:
1331:
1328:
1326:
1323:
1321:
1318:
1316:
1313:
1312:
1310:
1291:
1289:
1286:
1285:
1283:
1280:
1277:
1274:
1272:
1269:
1268:
1264:
1254:
1251:
1249:
1248:Levetiracetam
1246:
1244:
1241:
1239:
1236:
1234:
1231:
1229:
1226:
1224:
1221:
1219:
1216:
1214:
1211:
1209:
1206:
1205:
1203:
1199:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1177:Ethoxzolamide
1175:
1173:
1172:Acetazolamide
1170:
1168:
1164:
1163:
1161:
1159:
1158:CA inhibitors
1155:
1152:
1148:
1138:
1135:
1134:
1132:
1130:
1126:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1098:
1095:
1093:
1090:
1088:
1083:
1080:
1078:
1075:
1073:
1069:
1068:
1063:
1062:Trimethadione
1060:
1058:
1055:
1053:
1050:
1048:
1044:
1043:
1041:
1039:
1035:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1002:
1001:Oxcarbazepine
999:
997:
994:
992:
991:Carbamazepine
989:
987:
985:
980:
977:
975:
972:
970:
967:
965:
960:
957:
955:
952:
950:
947:
945:
942:
940:
935:
932:
930:
927:
925:
922:
920:
917:
915:
911:
910:
908:
906:
902:
899:
897:
891:
881:
878:
876:
871:
867:
866:
862:
861:
859:
855:
849:
846:
844:
841:
839:
836:
834:
831:
829:
825:
824:
822:
820:
816:
810:
807:
805:
802:
800:
797:
794:
790:
786:
783:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
735:
734:
729:
726:
724:
720:
719:
714:
711:
709:
708:Phenobarbital
706:
704:
703:Pentobarbital
701:
699:
696:
694:
691:
689:
686:
684:
680:
679:
677:
675:
672:
664:
661:
659:
655:
650:
646:
639:
634:
632:
627:
625:
620:
619:
616:
607:
603:
599:
595:
591:
587:
580:
579:
574:
565:
561:
557:
553:
549:
545:
538:
535:
532:
528:
527:
520:
517:
512:
508:
503:
498:
494:
490:
486:
482:
478:
471:
469:
465:
460:
456:
452:
448:
444:
440:
437:(4): 709–16.
436:
432:
424:
421:
418:
414:
413:
406:
403:
397:
392:
388:
384:
380:
373:
370:
363:
359:
356:
355:
351:
349:
347:
342:
340:
335:
333:
329:
325:
321:
317:
313:
299:
294:
290:
283:
274:
270:
263:
256:
252:
251:
249:
246:
241:
234:
232:
228:
195:
193:
189:
184:
176:
172:
168:
167:
165:
156:
152:
145:
141:
140:
138:
136:
132:
125:
121:
120:
118:
116:
112:
105:
101:
100:
98:
91:
87:
80:
76:
75:
73:
71:
67:
59:
55:
50:
46:
39:
34:
30:
25:
1340:Chloroarenes
1325:Benzodioxans
1238:Fenfluramine
1218:Brivaracetam
1167:Sulfonamides
1165:
1100:
1085:
1082:Phensuximide
1072:Ethosuximide
1067:Succinimides
1065:
1045:
1004:
984:Carboxamides
982:
962:
937:
924:Fosphenytoin
912:
873:
863:
826:
781:
731:
716:
688:Barbexaclone
683:Barbiturates
681:
589:
585:
547:
543:
537:
524:
519:
484:
480:
434:
430:
423:
410:
405:
386:
382:
372:
358:JNJ-26990990
348:is unknown.
343:
336:
312:JNJ-26489112
311:
310:
57:
53:
21:JNJ-26489112
1278:from market
1228:Carisbamate
1223:Cannabidiol
1109:Lamotrigine
1013:Lamotrigine
964:Fatty acids
959:Pheneturide
954:Phenacemide
929:Mephenytoin
828:Fatty acids
809:Stiripentol
804:Paraldehyde
768:Nimetazepam
748:Clorazepate
693:Metharbital
526:NCT01114698
412:NCT00579384
238: g·mol
79:871824-55-4
36:Identifiers
1335:Sulfamides
1309:Categories
1253:Perampanel
1243:Ganaxolone
1233:Etiracetam
1192:Zonisamide
1187:Topiramate
1137:Retigabine
1119:Zonisamide
1114:Topiramate
1097:Pregabalin
1092:Gabapentin
1077:Mesuximide
1028:Zonisamide
1023:Topiramate
1018:Rufinamide
1008:Lacosamide
974:Valpromide
914:Hydantoins
896:modulators
848:Vigabatrin
838:Valpromide
773:Nitrazepam
743:Clonazepam
723:Cenobamate
718:Carbamates
658:GABAergics
389:(8): e70.
364:References
328:topiramate
243:3D model (
231:Molar mass
144:G1TI012DLT
115:ChemSpider
70:CAS Number
45:IUPAC name
1288:Phase III
1276:Withdrawn
1213:Beclamide
1104:Imepitoin
1052:Ethadione
969:Valproate
934:Phenytoin
880:Tiagabine
870:Progabide
833:Valproate
799:Imepitoin
778:Temazepam
763:Midazolam
758:Lorazepam
728:Felbamate
713:Primidone
550:: 38–48.
1208:Albutoin
1182:Sultiame
919:Ethotoin
753:Diazepam
738:Clobazam
606:24680767
564:26689774
511:24205976
459:25545178
451:24560845
352:See also
324:epilepsy
104:11616111
1101:Others:
1005:Others:
939:Ureides
894:Channel
785:Bromide
782:Others:
502:4004761
192:Formula
124:9790860
90:PubChem
1271:WHO-EM
1201:Others
1150:Others
857:Others
604:
562:
509:
499:
457:
449:
314:is an
269:SMILES
236:278.71
455:S2CID
289:InChI
245:JSmol
674:PAMs
667:GABA
602:PMID
560:PMID
507:PMID
447:PMID
344:Its
135:UNII
649:N03
594:doi
552:doi
548:104
497:PMC
489:doi
439:doi
435:108
391:doi
160:EPA
94:CID
1311::
1284::
1099:;
1084:;
1070::
1064:;
1003:;
981:;
961:;
936:;
872:;
868::
791:,
780:;
736::
730:;
721::
715:;
600:.
590:69
588:.
558:.
546:.
505:.
495:.
485:56
483:.
479:.
467:^
453:.
445:.
433:.
387:35
385:.
381:.
334:.
209:Cl
206:11
56:)-
1169::
1089::
1049::
986::
966::
941::
916::
877::
795:)
787:(
685::
671:R
669:A
651:)
647:(
637:e
630:t
623:v
608:.
596::
566:.
554::
513:.
491::
461:.
441::
399:.
393::
247:)
224:S
221:4
218:O
215:2
212:N
203:H
200:9
197:C
162:)
158:(
58:N
54:S
52:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
