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based on one of these
Alpbach Workshops and co-edited by Squire won the Best Professional/ Scholarly Publishing Journal: Medicine Award. Squire published well over 100 original papers, together with many reviews and in 1981 a 700-page monograph on The Structural Basis of Muscular Contraction. He
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Squire JM, Chew M, Nneji G, Neal C, Barry J, Michel C. Quasi-periodic substructure in the microvessel endothelial glycocalyx: a possible explanation for molecular filtering? J Struct Biol. 2001 Dec;136(3):239-255.
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Knupp C, Offer G, Ranatunga KW, Squire JM. Probing muscle myosin motor action: X-ray (m3 and m6) interference measurements report motor domain not lever arm movement. J Mol Biol. 2009 Jul 10;390(2):168-181.
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Parry DA, Squire JM. Structural role of tropomyosin in muscle regulation: analysis of the X-ray diffraction patterns from relaxed and contracting muscles. J Mol Biol. 1973 Mar 25;75(1):33-55.
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contraction. His early contributions were the proposal of the steric blocking mechanism for the regulation of muscle contraction, the discovery of face (side) polarity in the
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Al-Khayat HA, Kensler RW, Squire JM, Marston SB, Morris EP. Atomic model of the human cardiac muscle myosin filament. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):318-323.
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until his official retirement in 2006, when he was head of the
Biological Structure and Function Section of what was then the Biomedical Sciences Division at
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Squire JM. General model of myosin filament structure. III. Molecular packing arrangements in myosin filaments. J Mol Biol. 1973 Jun 25;77(2):291-323.
239:, and the proposal of a general packing scheme of myosin molecules within the myosin filaments of all muscles. He was an expert on the
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also wrote or edited several other books on muscle and on fibrous proteins. His final works were on the unresolved problem of how
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Harford JJ, Squire JM. Time-resolved diffraction studies of muscle using synchrotron radiation. Rep. Prog. Phys. 60, 1723-1787.
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Small JV, Squire JM. Structural basis of contraction in vertebrate smooth muscle. J Mol Biol. 1972 Jun 14; 67(1):117-149.
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he initiated and organised the first five
Workshops on Coiled-coils, Collagen and Co-proteins held every four years in
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Squire JM. General model for the structure of all myosin-containing filaments. Nature. 1971 Oct 15;233(5320):457-462.
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259:. He founded and chaired both the Collaborative Computational Project Number 13 (CCP13) for the analysis of fibre
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in 1995. His final position was as honorary research fellow in the
Department of Physiology & Pharmacology at
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analysis of static and contracting muscle, and recently had been involved in the structure analysis of isolated
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112:(27 June 1945 – 31 January 2021) was a British professor of structural biophysics in the
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Squire JM (1981) The
Structural Basis of Muscular Contraction. Plenum Press, New York.
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Squire started his career as a senior lecturer at the
Biophysics Institute,
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data and the
Imperial Muscle Initiative (IMI). With Professor
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Parry DAD, Squire JM (Eds) J Struct Biol. 2002 Jan-Feb;137(1-2):
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The main focus of his research was on the structural basis of
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in London, UK, to head the
Biopolymer Group. He remained at
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contraction, as well as the structure and function of the
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Obituary: a tribute to
Professor John Michael Squire
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Imperial
College of Science, Technology and Medicine
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95:Visiting Professor of Biomedical Sciences at
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483:Deaths from the COVID-19 pandemic in England
90:Professor of Structural Biophysics in the
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132:structure. He was a Fellow of both the
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140:. He was an emeritus member of the US
468:Academics of the University of London
275:. In 2002 a special issue of the
215:, UK, and as a visiting professor at
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463:Academics of Imperial College London
458:Associates of King's College London
288:molecules interact to bring about
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448:People educated at Fettes College
382:"CCP13 - - Diamond Light Source"
16:English biophysicist (1945–2021)
453:Alumni of King's College London
144:and an honorary member of the
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277:Journal of Structural Biology
128:contraction and blood vessel
120:and a research fellow at the
157:COVID-19 pandemic in England
155:in January 2021, during the
146:British Biophysical Society
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265:David Parry (biophysicist)
116:, a visiting professor at
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257:single particle analysis
235:filaments of vertebrate
217:Imperial College London
118:Imperial College London
97:Imperial College London
124:, where he researched
478:British biophysicists
122:University of Bristol
102:University of Bristol
81:King's College London
209:University of London
177:University of London
134:Institute of Physics
114:University of London
92:University of London
253:electron microscopy
142:Biophysical Society
110:John Michael Squire
100:Research fellow at
35:John Michael Squire
473:British biologists
213:Bristol University
138:Society of Biology
261:X-ray diffraction
241:X-ray diffraction
193:Oxford University
189:Aarhus University
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53:31 January 2021
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25:John M Squire
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55:(2021-01-31)
45:27 June 1945
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443:2021 deaths
438:1945 births
69:Nationality
432:Categories
303:References
297:glycocalyx
130:glycocalyx
41:1945-06-27
163:Education
63:, England
61:Salisbury
223:Research
153:COVID-19
136:and the
273:Austria
269:Alpbach
72:British
290:muscle
282:myosin
245:myosin
233:myosin
229:muscle
219:, UK.
183:Career
126:muscle
286:actin
249:actin
284:and
255:and
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50:Died
31:Born
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