41:
248:
31:
297:. The specific link of this pathway remains to be found, as well as the explanation for why the polarization and distribution of KARs varies so much across neurons and brain regions. The proteins have been shown to pace the receptors and help explain KAR's role in maturation of neural circuits during
216:
about halfway, and then dips back out to the cytoplasm. This segment, termed the "p loop," determines the calcium permeability of the receptor. M2 turns into M3, another transmembrane segment which emerges on the extracellular face to complete the neurotransmitter binding site (a portion called S2).
284:
induces seizures, in part, by activation of kainate receptors containing the GluK2 subunit and also probably via AMPA receptors
Activation of kainate receptors containing the GluK1 subunit can also induce seizures but deletion of this subunit does not reduce seizure susceptibility to kainate or in
292:
has shown that kainate receptors have more than just an ionotropic (or directly changing a membrane's conductivity) role in neurons. The metabotropic (or indirect through secondary protein pathways) effect has been verified through many accessory proteins and sustained current through
244:. However, rise and decay times for postsynaptic potentials generated by KARs are slower than for AMPA postsynaptic potentials. Their permeability to Ca is usually very slight but varies with subunits and RNA editing at the tip of the p loop.
203:
Each KAR subunit begins with a 400-residue extracellular N-terminal domain, which plays a key role in assembly, followed by the first segment of the neurotransmitter-binding cleft, called S1. This segment then passes through the
1832:
1852:
304:
One of the larger connections and roles that kainate receptors have been shown to have is to several neurological diseases and conditions. KAR expression and distribution has shown a linkage to
260:
Many kainate receptors appear to exist as heteromers. The 'high-affinity' subunits GluK4 and GluK5 can only form functional channels as heteromers with 'low-affinity' subunits (GluK1-3).
3849:
1825:
200:
Since 2009 the kainate receptor subunits have been renamed to correspond with their gene name. Hence GluR5-7 are now GluK1-3 and KA1 and KA2 are GluK4 and GluK5, respectively.
3842:
1072:
1818:
1170:
348:
that are released This effect may occur quickly and last for a long time, and the effects of repetitive stimulation of KARs can be additive over time.
2901:
3871:
1065:
882:"Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus"
220:
Differences in the ligand binding pocket allow for the development of moderately subunit-selective kainate receptor agonists and antagonists.
3881:
2933:
2522:
497:
2841:
324:, and epilepsy among others. Most come through mutations of GluK1-5. The causation is unclear and the subject of further investigation.
285:
other seizure models. Deletion of either GluK1 or GluK2 does not alter kindling epileptogenesis or the expression of kindled seizures.
3770:
2597:
1058:
1481:
1469:
1501:
1378:
2397:
2103:
939:"Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity"
2755:
1514:
344:
will fire in response to future stimulation. Activating kainate receptors in the presynaptic cell can affect the amount of
217:
M4 begins extracellularly, and passes again through the membrane into the cytoplasm, forming the C-terminal of the protein.
2503:
1841:
95:
3835:
268:
Kainate receptors have both presynaptic and postsynaptic actions. They have a somewhat more limited distribution in the
103:
99:
67:
2651:
3130:
2923:
1536:
1493:
294:
240:
ions. The single channel conductance of kainate receptor channels is similar to that of AMPA channels, at about 20
185:
can form homomers (ex. a receptor composed entirely of GluR5) and heteromers (ex. a receptor composed of both GluR
1336:
309:
1050:
2622:
2556:
1886:
1550:
1089:
1044:
2768:
3876:
3785:
317:
40:
70:. They were first identified as a distinct receptor type through their selective activation by the agonist
3660:
3135:
2928:
2740:
2731:
1737:
477:
3655:
2583:
2280:
1085:
177:), which are similar to AMPA and NMDA receptor subunits and can be arranged in different ways to form a
983:"Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses"
2778:
2493:
2234:
994:
3165:
2290:
3707:
3140:
2546:
1973:
1871:
1750:
337:
60:
2607:
3750:
3083:
3078:
3001:
2918:
2773:
2762:
2592:
1844:
1553:
1288:
1097:
1020:
862:
618:
298:
178:
3519:
3504:
3036:
2906:
2866:
2209:
517:
389:
3755:
3735:
3730:
3687:
3514:
3484:
3175:
3073:
3046:
2996:
2963:
2943:
2938:
2881:
2876:
2861:
2851:
2831:
2826:
2417:
2377:
2325:
2063:
1998:
1988:
1983:
837:
Song I, Huganir RL (November 2002). "Regulation of AMPA receptors during synaptic plasticity".
3665:
3031:
3016:
2788:
2783:
2671:
2571:
2467:
2285:
2178:
1012:
960:
914:
854:
819:
770:
719:
670:
610:
572:
509:
362:
208:, forming the first of three membrane-spanning regions, M1. The M2 segment then begins on the
173:
163:
153:
140:
127:
3551:
3546:
3541:
3536:
3068:
2488:
1963:
449:
444:
3220:
2537:
2483:
2199:
1876:
1328:
1040:
1002:
950:
904:
896:
846:
809:
801:
760:
750:
709:
701:
660:
652:
602:
562:
554:
345:
321:
193:), however, KA1 and KA2 can only form functional receptors by combining with one of the GluR
64:
2158:
1810:
3720:
3670:
3430:
3350:
3315:
3215:
3051:
2886:
2656:
2566:
2335:
2300:
2133:
2068:
1911:
367:
998:
690:"Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis"
3630:
3610:
3375:
3310:
3230:
3210:
3006:
2478:
2407:
2194:
2113:
1162:
1114:
909:
900:
881:
814:
789:
714:
689:
665:
640:
567:
542:
427:
341:
241:
850:
606:
3865:
3800:
3795:
3775:
3635:
3600:
3455:
3450:
3440:
3415:
3410:
3345:
3305:
3265:
2846:
2551:
2463:
2402:
2347:
2315:
2174:
2108:
1928:
1901:
1853:
1640:
1570:
1154:
1106:
805:
558:
472:
467:
377:
305:
289:
213:
205:
91:
87:
83:
1024:
247:
17:
3590:
3420:
3390:
3295:
3260:
3195:
3180:
2958:
2459:
2432:
2387:
2184:
2170:
2138:
2088:
2043:
1758:
866:
705:
622:
955:
938:
755:
738:
3780:
3765:
3745:
3715:
3645:
3529:
3509:
3499:
3494:
3474:
3435:
3385:
3380:
3365:
3355:
3320:
3270:
3240:
3235:
3225:
3145:
3088:
3041:
2973:
2948:
2896:
2811:
2697:
2635:
2612:
2320:
2305:
2251:
2239:
2053:
2028:
1916:
1891:
1081:
383:
372:
332:
Unlike AMPA receptors, kainate receptors play only a minor role in signaling at
281:
229:
34:
656:
3818:
3790:
3740:
3725:
3702:
3697:
3692:
3625:
3595:
3585:
3524:
3460:
3445:
3425:
3370:
3340:
3325:
3300:
3285:
3250:
3245:
3205:
3200:
3170:
3155:
3115:
3093:
3056:
3026:
3011:
2991:
2749:
2719:
2702:
2692:
2447:
2437:
2412:
2367:
2244:
2229:
2224:
2204:
2163:
2153:
2143:
2123:
2118:
2078:
2073:
2033:
2023:
2008:
1948:
1923:
880:
Contractor A, Swanson GT, Sailer A, O'Gorman S, Heinemann SF (November 2000).
433:
3615:
3605:
3563:
3489:
3479:
3405:
3400:
3360:
3335:
3330:
3280:
3255:
3185:
3160:
3150:
3125:
3120:
3110:
2986:
2871:
2856:
2836:
2821:
2816:
2707:
2532:
2527:
2473:
2362:
2357:
2352:
2310:
2219:
2214:
2189:
2098:
2038:
2018:
2013:
2003:
1993:
1968:
1896:
1007:
982:
237:
209:
1016:
964:
918:
858:
823:
774:
723:
674:
614:
576:
513:
593:
Huettner JE (August 2003). "Kainate receptors and synaptic transmission".
3760:
3558:
3465:
3290:
3275:
3190:
3105:
3021:
2911:
2793:
2724:
2714:
2576:
2442:
2340:
2148:
455:
394:
765:
641:"Kainate receptors coming of age: milestones of two decades of research"
30:
3804:
3650:
3640:
3620:
3575:
3061:
2676:
2661:
2627:
2561:
2452:
2330:
2048:
1978:
1958:
1906:
1685:
1680:
1429:
439:
416:
333:
71:
3680:
3580:
2953:
2684:
2666:
2643:
1938:
1933:
1858:
Tooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
1675:
1670:
1665:
1660:
1655:
1650:
1449:
1444:
1439:
1434:
1424:
1419:
1414:
1409:
1404:
1399:
1394:
1389:
1313:
1305:
1297:
1258:
1250:
1242:
1234:
1226:
1218:
1210:
1202:
1194:
1186:
1178:
634:
632:
313:
233:
688:
Fritsch B, Reis J, Gasior M, Kaminski RM, Rogawski MA (April 2014).
280:
receptors, and their function is less well defined. The convulsant
3675:
3100:
2891:
2617:
2427:
1953:
1943:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1718:
1710:
1645:
1620:
1615:
1610:
1605:
1600:
1589:
1584:
1579:
1574:
1459:
1454:
1360:
1352:
1344:
1281:
1276:
1271:
1266:
1142:
1137:
1132:
1127:
1122:
422:
269:
168:
158:
145:
132:
119:
78:
Digenea simplex. They have been traditionally classified as a non-
75:
39:
29:
3568:
3395:
2981:
2968:
2602:
2422:
2392:
2382:
2295:
2128:
2093:
2083:
1881:
1368:
541:
Collingridge GL, Olsen RW, Peters J, Spedding M (January 2009).
411:
406:
277:
273:
107:
79:
1814:
1054:
2806:
496:
Dingledine R, Borges K, Bowie D, Traynelis SF (March 1999).
106:
by modulating release of the inhibitory neurotransmitter
102:. Presynaptic kainate receptors have been implicated in
3098:
Uncompetitive pore blockers (mostly dizocilpine site):
2504:
2502:
2260:
1851:
1749:
1736:
1696:
1631:
1561:
1549:
1527:
1377:
1327:
1153:
1105:
1096:
118:There are five types of kainate receptor subunits,
340:, affecting the likelihood that the postsynaptic
98:. Postsynaptic kainate receptors are involved in
639:Contractor A, Mulle C, Swanson GT (March 2011).
386:– the agonist after which the receptor is named
2756:
2741:
543:"A nomenclature for ligand-gated ion channels"
1826:
1066:
981:Schmitz D, Mellor J, Nicoll RA (March 2001).
8:
790:"Therapeutic potential of kainate receptors"
232:formed by kainate receptors is permeable to
3843:Metabotropic glutamate receptor modulators
1833:
1819:
1811:
1746:
1558:
1102:
1073:
1059:
1051:
976:
974:
588:
586:
336:. Kainate receptors have a subtle role in
3850:Glutamate metabolism/transport modulators
1043:at the U.S. National Library of Medicine
1006:
954:
908:
813:
764:
754:
739:"Kainate receptors in health and disease"
713:
664:
566:
2262:
932:
930:
928:
246:
488:
27:Class of ionotropic glutamate receptors
3573:Alcohols/volatile anesthetics/related:
212:face of the membrane, pushes into the
2729:Other positive allosteric modulators:
2509:Tooltip N-Methyl-D-aspartate receptor
498:"The glutamate receptor ion channels"
7:
737:Lerma J, Marques JM (October 2013).
380:(glutamate) – the endogenous agonist
3470:Ifenprodil (NR2B) site antagonists:
794:CNS Neuroscience & Therapeutics
2034:Pesampator (BIIB-104, PF-04958242)
901:10.1523/JNEUROSCI.20-22-08269.2000
25:
110:through a presynaptic mechanism.
74:, a drug first isolated from the
806:10.1111/j.1755-5949.2010.00204.x
559:10.1016/j.neuropharm.2008.06.063
86:. KARs are less understood than
3510:Rislenemdaz (CERC-301, MK-0657)
2457:Negative allosteric modulators:
2345:Positive allosteric modulators:
2168:Negative allosteric modulators:
1921:Positive allosteric modulators:
181:, a four subunit receptor. GluR
82:-type receptor, along with the
3872:Ionotropic glutamate receptors
2746:Tooltip Dehydroepiandrosterone
2054:Tulrampator (S-47445, CX-1632)
1949:Farampator (CX-691, ORG-24448)
706:10.1523/JNEUROSCI.5307-13.2014
96:ionotropic glutamate receptors
1:
3836:Receptor/signaling modulators
3685:Unknown/unsorted antagonists:
2249:Unknown/unsorted antagonists:
1842:Ionotropic glutamate receptor
851:10.1016/S0166-2236(02)02270-1
607:10.1016/S0301-0082(03)00122-9
288:Recent investigation through
3882:Glutamate (neurotransmitter)
956:10.1016/j.neuron.2005.01.031
756:10.1016/j.neuron.2013.09.045
104:inhibitory neurotransmission
100:excitatory neurotransmission
3534:NR2A-selective antagonists:
3066:Polyamine site antagonists:
2291:Acromelic acid (acromelate)
1877:Acromelic acid (acromelate)
889:The Journal of Neuroscience
694:The Journal of Neuroscience
3898:
1974:Hydrochlorothiazide (HCTZ)
937:Mayer ML (February 2005).
788:Matute C (December 2011).
657:10.1016/j.tins.2010.12.002
436:– also an AMPAR antagonist
251:Known KAR Roles in Neurons
3827:
2916:Glycine site antagonists:
1633:Voltage- and ligand-gated
1090:ligand-gated ion channels
2804:Competitive antagonists:
2712:Polyamine site agonists:
2698:Neboglamine (nebostinel)
2267:Tooltip Kainate receptor
1045:Medical Subject Headings
595:Progress in Neurobiology
3786:Pentamidine isethionate
3530:Traxoprodil (CP-101606)
2769:Epipregnanolone sulfate
1379:Nicotinic acetylcholine
1008:10.1126/science.1057105
839:Trends in Neurosciences
645:Trends in Neurosciences
502:Pharmacological Reviews
3816:Allosteric modulators:
3751:Ipenoxazone (MLV-6976)
3406:Pethidine (meperidine)
3027:Licostinel (ACEA-1021)
2949:Apimostinel (NRX-1074)
2613:Apimostinel (NRX-1074)
2581:Glycine site agonists:
2413:Licostinel (ACEA-1021)
2124:Licostinel (ACEA-1021)
2009:Mibampator (LY-451395)
478:Long term potentiation
252:
45:
37:
3485:CO-101244 (PD-174494)
3201:Delucemine (NPS-1506)
3151:Alazocine (SKF-10047)
1086:cell surface receptor
250:
53:kainic acid receptors
43:
33:
3505:Radiprodil (RGH-896)
3480:Buphenine (nylidrin)
3057:Rapastinel (GLYX-13)
2872:Midafotel (d-CPPene)
2779:Pregnenolone sulfate
2703:Rapastinel (GLYX-13)
2494:Pregnenolone sulfate
2235:Pregnenolone sulfate
1751:Purinergic receptors
63:that respond to the
61:ionotropic receptors
18:Kainic acid receptor
2736:-Hydroxycholesterol
2547:Homoquinolinic acid
2520:Main site agonists:
2278:Main site agonists:
1872:5-Fluorowillardiine
1869:Main site agonists:
999:2001Sci...291.1972S
430:– endogenous ligand
338:synaptic plasticity
3084:Diethylenetriamine
2763:prasterone sulfate
2538:Homocysteic acid (
2281:5-Bromowillardiine
1519:β1δε - Muscle type
1098:Cys-loop receptors
295:G-protein cascades
253:
46:
38:
3859:
3858:
3710:
3666:Trichloroethylene
3611:Ethanol (alcohol)
2976:
2919:4-Cl-KYN (AV-101)
2687:
2679:
2646:
2638:
2630:
2587:
2572:Tetrazolylglycine
2541:
2479:Ethanol (alcohol)
2468:sodium thiopental
2286:5-Iodowillardiine
2195:Ethanol (alcohol)
2179:sodium thiopental
1808:
1807:
1804:
1803:
1732:
1731:
1563:Ligand-gated only
1545:
1544:
547:Neuropharmacology
363:5-Iodowillardiine
346:neurotransmitters
49:Kainate receptors
16:(Redirected from
3889:
3708:
3661:Trichloroethanol
3221:Dextromethorphan
2974:
2758:
2747:
2743:
2685:
2677:
2644:
2636:
2628:
2585:
2539:
2510:
2506:
2268:
2264:
2099:Fanapanel (MPQX)
1859:
1855:
1835:
1828:
1821:
1812:
1747:
1559:
1103:
1075:
1068:
1061:
1052:
1041:Kainate+Receptor
1029:
1028:
1010:
993:(5510): 1972–6.
978:
969:
968:
958:
934:
923:
922:
912:
886:
877:
871:
870:
834:
828:
827:
817:
785:
779:
778:
768:
758:
734:
728:
727:
717:
685:
679:
678:
668:
636:
627:
626:
590:
581:
580:
570:
538:
532:
531:
529:
528:
522:
516:. Archived from
493:
322:bipolar disorder
290:voltage clamping
65:neurotransmitter
21:
3897:
3896:
3892:
3891:
3890:
3888:
3887:
3886:
3862:
3861:
3860:
3855:
3823:
3721:Flufenamic acid
3656:Trichloroethane
3431:Rhynchophylline
3351:Methoxphenidine
3316:Levomilnacipran
3216:Dextromethadone
3141:α-Endopsychosin
2745:
2657:Dimethylglycine
2567:Quinolinic acid
2508:
2498:
2336:Quisqualic acid
2266:
2256:
1912:Quisqualic acid
1857:
1847:
1839:
1809:
1800:
1728:
1722:
1714:
1692:
1627:
1541:
1523:
1518:
1510:- Ganglion type
1509:
1505:
1497:
1489:
1485:
1477:
1473:
1373:
1364:
1356:
1348:
1340:
1323:
1317:
1309:
1301:
1292:
1262:
1254:
1246:
1238:
1230:
1222:
1214:
1206:
1198:
1190:
1182:
1174:
1166:
1149:
1118:
1092:
1079:
1037:
1032:
980:
979:
972:
936:
935:
926:
895:(22): 8269–78.
884:
879:
878:
874:
836:
835:
831:
787:
786:
782:
736:
735:
731:
700:(17): 5765–75.
687:
686:
682:
638:
637:
630:
592:
591:
584:
540:
539:
535:
526:
524:
520:
495:
494:
490:
486:
464:
419:– non-selective
403:
359:
354:
330:
266:
258:
226:
196:
192:
188:
184:
149:
136:
123:
116:
28:
23:
22:
15:
12:
11:
5:
3895:
3893:
3885:
3884:
3879:
3877:Cell signaling
3874:
3864:
3863:
3857:
3856:
3854:
3853:
3846:
3839:
3828:
3825:
3824:
3822:
3821:
3809:
3808:
3798:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3758:
3753:
3748:
3743:
3738:
3733:
3728:
3723:
3718:
3713:
3705:
3700:
3695:
3690:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3631:Methoxyflurane
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3566:
3561:
3549:
3544:
3539:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3463:
3458:
3453:
3448:
3443:
3438:
3433:
3428:
3423:
3418:
3413:
3408:
3403:
3398:
3393:
3388:
3383:
3378:
3376:Nitromemantine
3373:
3368:
3363:
3358:
3353:
3348:
3343:
3338:
3333:
3328:
3323:
3318:
3313:
3311:Levomethorphan
3308:
3303:
3298:
3293:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3231:Dieticyclidine
3228:
3223:
3218:
3213:
3211:Dextrallorphan
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3168:
3166:Argiotoxin-636
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3091:
3086:
3081:
3079:Diaminopropane
3076:
3071:
3059:
3054:
3049:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3009:
3007:Kynurenic acid
3004:
2999:
2994:
2989:
2984:
2979:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2909:
2904:
2899:
2894:
2889:
2884:
2879:
2874:
2869:
2864:
2859:
2854:
2849:
2844:
2839:
2834:
2829:
2824:
2819:
2814:
2809:
2797:
2796:
2791:
2786:
2781:
2776:
2771:
2766:
2753:
2738:
2722:
2717:
2705:
2700:
2695:
2690:
2682:
2674:
2669:
2664:
2659:
2654:
2649:
2641:
2633:
2625:
2620:
2615:
2610:
2605:
2600:
2595:
2590:
2574:
2569:
2564:
2559:
2554:
2549:
2544:
2535:
2530:
2525:
2513:
2511:
2500:
2499:
2497:
2496:
2491:
2486:
2481:
2476:
2471:
2450:
2445:
2440:
2435:
2430:
2425:
2420:
2415:
2410:
2408:Kynurenic acid
2405:
2400:
2395:
2390:
2385:
2380:
2371:
2370:
2365:
2360:
2355:
2350:
2338:
2333:
2328:
2323:
2318:
2313:
2308:
2303:
2298:
2293:
2288:
2283:
2271:
2269:
2258:
2257:
2255:
2254:
2242:
2237:
2232:
2227:
2222:
2217:
2212:
2207:
2202:
2197:
2192:
2187:
2182:
2161:
2156:
2151:
2146:
2141:
2136:
2131:
2126:
2121:
2116:
2114:Kynurenic acid
2111:
2106:
2101:
2096:
2091:
2086:
2081:
2076:
2071:
2066:
2057:
2056:
2051:
2046:
2041:
2036:
2031:
2026:
2021:
2016:
2011:
2006:
2001:
1996:
1991:
1986:
1981:
1976:
1971:
1966:
1961:
1956:
1951:
1946:
1941:
1936:
1931:
1926:
1914:
1909:
1904:
1899:
1894:
1889:
1884:
1879:
1874:
1862:
1860:
1849:
1848:
1840:
1838:
1837:
1830:
1823:
1815:
1806:
1805:
1802:
1801:
1799:
1798:
1797:
1796:
1791:
1786:
1781:
1776:
1771:
1766:
1755:
1753:
1744:
1742:gated channels
1734:
1733:
1730:
1729:
1727:
1726:
1725:
1724:
1720:
1716:
1712:
1702:
1700:
1694:
1693:
1691:
1690:
1689:
1688:
1683:
1678:
1673:
1668:
1663:
1658:
1653:
1648:
1637:
1635:
1629:
1628:
1626:
1625:
1624:
1623:
1618:
1613:
1608:
1603:
1593:
1587:
1582:
1577:
1567:
1565:
1556:
1547:
1546:
1543:
1542:
1540:
1539:
1537:Zinc-activated
1533:
1531:
1525:
1524:
1522:
1521:
1516:
1512:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1471:
1463:
1462:
1457:
1452:
1447:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1383:
1381:
1375:
1374:
1372:
1371:
1366:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1333:
1331:
1325:
1324:
1322:
1321:
1320:
1319:
1315:
1311:
1307:
1303:
1299:
1290:
1286:
1285:
1284:
1279:
1274:
1269:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1236:
1232:
1228:
1224:
1220:
1216:
1212:
1208:
1204:
1200:
1196:
1192:
1188:
1184:
1180:
1176:
1172:
1164:
1159:
1157:
1151:
1150:
1148:
1147:
1146:
1145:
1140:
1135:
1130:
1125:
1116:
1111:
1109:
1107:5-HT/serotonin
1100:
1094:
1093:
1080:
1078:
1077:
1070:
1063:
1055:
1049:
1048:
1036:
1035:External links
1033:
1031:
1030:
970:
924:
872:
845:(11): 578–88.
829:
780:
749:(2): 292–311.
729:
680:
628:
601:(5): 387–407.
582:
533:
487:
485:
482:
481:
480:
475:
470:
463:
460:
459:
458:
453:
447:
442:
437:
431:
428:Kynurenic acid
425:
420:
414:
409:
402:
399:
398:
397:
392:
387:
381:
375:
370:
365:
358:
355:
353:
350:
329:
326:
265:
262:
257:
254:
225:
222:
194:
190:
186:
182:
147:
134:
121:
115:
112:
92:NMDA receptors
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3894:
3883:
3880:
3878:
3875:
3873:
3870:
3869:
3867:
3852:
3851:
3847:
3845:
3844:
3840:
3838:
3837:
3834:
3830:
3829:
3826:
3820:
3817:
3814:
3811:
3810:
3806:
3802:
3801:Transcrocetin
3799:
3797:
3796:Psychotridine
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3776:Niflumic acid
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3682:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3636:Nitrous oxide
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3601:Diethyl ether
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3570:
3567:
3565:
3562:
3560:
3557:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3467:
3464:
3462:
3459:
3457:
3456:Tenocyclidine
3454:
3452:
3451:Tabernanthine
3449:
3447:
3444:
3442:
3441:Rolicyclidine
3439:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3417:
3416:Phencyclidine
3414:
3412:
3411:Phencyclamine
3409:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3346:Methoxetamine
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3306:Levomethadone
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3266:Fluorolintane
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2847:Kaitocephalin
2845:
2843:
2840:
2838:
2835:
2833:
2830:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2802:
2799:
2798:
2795:
2792:
2790:
2787:
2785:
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2764:
2760:
2754:
2751:
2744:
2739:
2737:
2735:
2730:
2726:
2723:
2721:
2718:
2716:
2713:
2709:
2706:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2683:
2681:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2642:
2640:
2634:
2632:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2582:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2552:Ibotenic acid
2550:
2548:
2545:
2543:
2536:
2534:
2531:
2529:
2526:
2524:
2521:
2518:
2515:
2514:
2512:
2507:
2501:
2495:
2492:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2469:
2465:
2464:pentobarbital
2461:
2458:
2454:
2451:
2449:
2446:
2444:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2403:Kaitocephalin
2401:
2399:
2396:
2394:
2391:
2389:
2386:
2384:
2381:
2379:
2376:
2373:
2372:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2349:
2348:Cyclothiazide
2346:
2342:
2339:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2316:Ibotenic acid
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2287:
2284:
2282:
2279:
2276:
2273:
2272:
2270:
2265:
2259:
2253:
2250:
2246:
2243:
2241:
2238:
2236:
2233:
2231:
2228:
2226:
2223:
2221:
2218:
2216:
2213:
2211:
2208:
2206:
2203:
2201:
2198:
2196:
2193:
2191:
2188:
2186:
2183:
2180:
2176:
2175:pentobarbital
2172:
2169:
2165:
2162:
2160:
2157:
2155:
2152:
2150:
2147:
2145:
2142:
2140:
2137:
2135:
2132:
2130:
2127:
2125:
2122:
2120:
2117:
2115:
2112:
2110:
2109:Kaitocephalin
2107:
2105:
2102:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2082:
2080:
2077:
2075:
2072:
2070:
2067:
2065:
2062:
2059:
2058:
2055:
2052:
2050:
2047:
2045:
2042:
2040:
2037:
2035:
2032:
2030:
2027:
2025:
2022:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1997:
1995:
1992:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1970:
1967:
1965:
1962:
1960:
1957:
1955:
1952:
1950:
1947:
1945:
1942:
1940:
1937:
1935:
1932:
1930:
1929:Cyclothiazide
1927:
1925:
1922:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1902:Ibotenic acid
1900:
1898:
1895:
1893:
1890:
1888:
1885:
1883:
1880:
1878:
1875:
1873:
1870:
1867:
1864:
1863:
1861:
1856:
1850:
1846:
1843:
1836:
1831:
1829:
1824:
1822:
1817:
1816:
1813:
1795:
1792:
1790:
1787:
1785:
1782:
1780:
1777:
1775:
1772:
1770:
1767:
1765:
1762:
1761:
1760:
1757:
1756:
1754:
1752:
1748:
1745:
1743:
1739:
1735:
1723:
1717:
1715:
1709:
1708:
1707:
1704:
1703:
1701:
1699:
1695:
1687:
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1643:
1642:
1639:
1638:
1636:
1634:
1630:
1622:
1619:
1617:
1614:
1612:
1609:
1607:
1604:
1602:
1599:
1598:
1597:
1594:
1591:
1588:
1586:
1583:
1581:
1578:
1576:
1572:
1569:
1568:
1566:
1564:
1560:
1557:
1555:
1552:
1548:
1538:
1535:
1534:
1532:
1530:
1526:
1520:
1513:
1511:
1500:
1498:
1492:
1490:
1480:
1478:
1468:
1465:
1464:
1461:
1458:
1456:
1453:
1451:
1448:
1446:
1443:
1441:
1438:
1436:
1433:
1431:
1428:
1426:
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1396:
1393:
1391:
1388:
1385:
1384:
1382:
1380:
1376:
1370:
1367:
1365:
1359:
1357:
1351:
1349:
1343:
1341:
1335:
1334:
1332:
1330:
1326:
1318:
1312:
1310:
1304:
1302:
1296:
1295:
1294:
1287:
1283:
1280:
1278:
1275:
1273:
1270:
1268:
1265:
1263:
1257:
1255:
1249:
1247:
1241:
1239:
1233:
1231:
1225:
1223:
1217:
1215:
1209:
1207:
1201:
1199:
1193:
1191:
1185:
1183:
1177:
1175:
1169:
1168:
1167:
1161:
1160:
1158:
1156:
1152:
1144:
1141:
1139:
1136:
1134:
1131:
1129:
1126:
1124:
1121:
1120:
1119:
1113:
1112:
1110:
1108:
1104:
1101:
1099:
1095:
1091:
1087:
1083:
1076:
1071:
1069:
1064:
1062:
1057:
1056:
1053:
1046:
1042:
1039:
1038:
1034:
1026:
1022:
1018:
1014:
1009:
1004:
1000:
996:
992:
988:
984:
977:
975:
971:
966:
962:
957:
952:
949:(4): 539–52.
948:
944:
940:
933:
931:
929:
925:
920:
916:
911:
906:
902:
898:
894:
890:
883:
876:
873:
868:
864:
860:
856:
852:
848:
844:
840:
833:
830:
825:
821:
816:
811:
807:
803:
799:
795:
791:
784:
781:
776:
772:
767:
762:
757:
752:
748:
744:
740:
733:
730:
725:
721:
716:
711:
707:
703:
699:
695:
691:
684:
681:
676:
672:
667:
662:
658:
654:
651:(3): 154–63.
650:
646:
642:
635:
633:
629:
624:
620:
616:
612:
608:
604:
600:
596:
589:
587:
583:
578:
574:
569:
564:
560:
556:
552:
548:
544:
537:
534:
523:on 2009-02-13
519:
515:
511:
507:
503:
499:
492:
489:
483:
479:
476:
474:
473:AMPA receptor
471:
469:
468:NMDA receptor
466:
465:
461:
457:
454:
451:
448:
446:
443:
441:
438:
435:
432:
429:
426:
424:
421:
418:
415:
413:
410:
408:
405:
404:
400:
396:
393:
391:
388:
385:
382:
379:
378:Glutamic acid
376:
374:
371:
369:
366:
364:
361:
360:
356:
351:
349:
347:
343:
339:
335:
327:
325:
323:
319:
315:
311:
307:
306:schizophrenia
302:
300:
296:
291:
286:
283:
279:
275:
271:
263:
261:
255:
249:
245:
243:
239:
235:
231:
223:
221:
218:
215:
214:cell membrane
211:
207:
206:cell membrane
201:
198:
180:
176:
175:
170:
166:
165:
160:
156:
155:
150:
143:
142:
137:
130:
129:
124:
113:
111:
109:
105:
101:
97:
93:
89:
85:
84:AMPA receptor
81:
77:
73:
69:
66:
62:
58:
54:
50:
44:Glutamic acid
42:
36:
32:
19:
3848:
3841:
3832:
3831:
3815:
3812:
3684:
3591:Cyclopropane
3572:
3555:
3533:
3469:
3421:Propoxyphene
3391:Orphenadrine
3296:Ketobemidone
3261:Eticyclidine
3196:Coronaridine
3181:ARL-15896-AR
3097:
3065:
2977:-Cycloserine
2959:Carisoprodol
2915:
2803:
2801:Antagonists:
2800:
2733:
2728:
2711:
2639:-Cycloserine
2580:
2519:
2516:
2460:Barbiturates
2456:
2433:Selurampanel
2388:Dasolampanel
2375:Antagonists:
2374:
2344:
2277:
2274:
2261:
2248:
2185:Cyclopropane
2171:Barbiturates
2167:
2139:Selurampanel
2089:Dasolampanel
2061:Antagonists:
2060:
2044:Pramiracetam
1920:
1868:
1865:
1741:
1705:
1697:
1632:
1595:
1562:
1528:
1466:
1386:
990:
986:
946:
942:
892:
888:
875:
842:
838:
832:
800:(6): 661–9.
797:
793:
783:
766:10261/308872
746:
742:
732:
697:
693:
683:
648:
644:
598:
594:
550:
546:
536:
525:. Retrieved
518:the original
505:
501:
491:
331:
318:Huntington's
303:
287:
267:
259:
227:
219:
202:
199:
172:
162:
152:
139:
126:
117:
94:, the other
56:
52:
48:
47:
3781:Pentamidine
3766:Minocycline
3746:Hodgkinsine
3716:Dexanabinol
3646:Sevoflurane
3500:Isoxsuprine
3495:Haloperidol
3475:Besonprodil
3436:Rimantadine
3386:Norketamine
3381:Noribogaine
3356:Milnacipran
3321:Levorphanol
3271:Gacyclidine
3241:Dizocilpine
3236:Diphenidine
3226:Dextrorphan
3146:Alaproclate
3089:Huperzine A
3042:Meprobamate
3002:Harkoseride
2897:Perzinfotel
2774:Plazinemdor
2321:Kainic acid
2306:Domoic acid
2252:Minocycline
2240:Sevoflurane
1917:Willardiine
1892:Domoic acid
1082:Ion channel
508:(1): 7–61.
401:Antagonists
384:Kainic acid
373:Domoic acid
299:development
282:kainic acid
230:ion channel
224:Conductance
210:cytoplasmic
35:Kainic acid
3866:Categories
3819:AGN-241751
3791:Piretanide
3741:Furosemide
3726:Flupirtine
3703:Conantokin
3698:Caroverine
3693:Bumetanide
3626:Isoflurane
3596:Desflurane
3586:Chloroform
3525:Safaprodil
3520:Ro 25-6981
3461:Tiletamine
3446:Sabeluzole
3426:Remacemide
3371:Neramexane
3341:Methorphan
3326:Loperamide
3301:Lanicemine
3286:Indantadol
3251:Esketamine
3246:Ephenidine
3206:Dexoxadrol
3171:Arketamine
3156:Amantadine
3116:3-MeO-PCMo
3094:Putrescine
3037:MDL-105519
3012:Kynurenine
2992:Gavestinel
2907:SDZ-220581
2867:MDL-100453
2750:prasterone
2720:Spermidine
2693:Milacemide
2598:ACC (ACPC)
2484:Evans blue
2448:Topiramate
2438:Tezampanel
2368:Isoflurane
2245:Talampanel
2230:Perampanel
2225:Isoflurane
2210:GYKI-53655
2205:GYKI-52466
2200:Evans blue
2164:Zonampanel
2154:Topiramate
2144:Tezampanel
2119:Kynurenine
2079:Caroverine
2074:Becampanel
2024:Oxiracetam
1924:Aniracetam
1845:modulators
1554:glutamates
1551:Ionotropic
1467:pentamers:
885:(abstract)
553:(1): 2–5.
527:2007-12-28
521:(abstract)
484:References
434:Tezampanel
390:LY-339,434
328:Plasticity
310:depression
256:Heteromers
197:subunits.
3833:See also:
3813:Unsorted:
3756:MDL-27266
3736:FR-115427
3731:FPL-12495
3688:ARR-15896
3616:Halothane
3606:Enflurane
3564:Magnesium
3515:Ro 8-4304
3490:Eliprodil
3401:PD-137889
3361:Morphanol
3336:Methadone
3331:Memantine
3281:Ibogamine
3256:Etoxadrol
3186:ARL-16247
3176:ARL-12495
3161:Aptiganel
3126:4-MeO-PCP
3121:3-MeO-PCP
3111:3-MeO-PCE
3074:Co 101676
3047:MRZ 2/576
2997:GV-196771
2987:Felbamate
2964:CGP-39653
2944:ACEA-1328
2939:ACEA-1011
2882:NPC-17742
2877:NPC-12626
2862:LY-274614
2857:LY-235959
2852:LY-233053
2837:CGS-19755
2832:CGP-40116
2827:CGP-39653
2822:CGP-39551
2817:CGP-37849
2807:AP5 (APV)
2708:Sarcosine
2584:β-Fluoro-
2533:Glutamate
2528:Aspartate
2517:Agonists:
2474:Enflurane
2418:LY-382884
2378:ACEA-1011
2363:Halothane
2358:Enflurane
2353:Diazoxide
2326:LY-339434
2311:Glutamate
2275:Agonists:
2220:Irampanel
2215:Halothane
2190:Enflurane
2064:ACEA-1011
2039:Piracetam
2019:ORG-26576
2014:Nooglutyl
2004:LY-503430
1999:LY-451646
1994:LY-404187
1989:LY-395153
1984:LY-392098
1969:Diazoxide
1897:Glutamate
1866:Agonists:
1387:monomers:
238:potassium
114:Structure
68:glutamate
3761:Metaphit
3671:Urethane
3559:Hydrogen
3556:Cations:
3466:Tramadol
3291:Ketamine
3276:Ibogaine
3191:Budipine
3106:3-HO-PCP
3032:LU-73068
3022:L-701324
3017:L-689560
2924:5,7-DCKA
2912:Selfotel
2794:SAGE-718
2789:SAGE-301
2784:SAGE-201
2725:Spermine
2715:Neomycin
2680:-Alanine
2672:L-687414
2631:-Alanine
2588:-alanine
2577:Theanine
2443:Theanine
2341:SYM-2081
2149:Theanine
1698:‘Orphan’
1025:24169827
1017:11239159
965:15721240
919:11069933
859:12392933
824:21129167
775:24139035
724:24760837
675:21256604
615:14511698
577:18655795
514:10049997
462:See also
456:Theanine
395:SYM-2081
357:Agonists
334:synapses
189:and GluR
179:tetramer
3805:saffron
3651:Toluene
3641:Octanol
3621:Hexanol
3576:Benzene
3552:TCN-213
3547:TCN-201
3542:MPX-007
3537:MPX-004
3131:8A-PDHQ
3069:Arcaine
3062:ZD-9379
2759:sulfate
2688:-Serine
2662:Glycine
2647:-Serine
2562:Proline
2489:NS-3763
2462:(e.g.,
2453:UBP-302
2331:Proline
2173:(e.g.,
2049:S-18986
1979:IDRA-21
1964:CX-1942
1959:CX-1739
1907:Proline
1596:Kainate
1329:Glycine
995:Bibcode
987:Science
910:6773182
867:1993509
815:3430855
715:3996208
666:3051042
623:5108956
568:2847504
450:UBP-316
445:UBP-310
440:UBP-302
417:Ethanol
352:Ligands
72:kainate
59:), are
3681:Xylene
3581:Butane
2954:AV-101
2667:HA-966
1954:CX-717
1944:CX-614
1939:CX-546
1934:CX-516
1047:(MeSH)
1023:
1015:
963:
943:Neuron
917:
907:
865:
857:
822:
812:
773:
743:Neuron
722:
712:
673:
663:
621:
613:
575:
565:
512:
452:(ACET)
314:autism
234:sodium
167:) and
3676:Xenon
3136:18-MC
3101:2-MDP
2929:7-CKA
2892:PEAQX
2618:B6B21
2608:AK-51
2542:-HCA)
2505:NMDAR
2428:NS102
2159:YM90K
1854:AMPAR
1021:S2CID
863:S2CID
619:S2CID
423:NS102
272:than
270:brain
264:Roles
174:GRIK5
164:GRIK4
154:GRIK3
141:GRIK2
128:GRIK1
76:algae
51:, or
3771:MPEP
3711:-αAA
3569:Zinc
3396:PCPr
3366:NEFA
3052:PNQX
2982:DNQX
2969:CNQX
2902:PPDA
2887:PBPD
2757:DHEA
2742:DHEA
2652:DHPG
2603:ACPD
2593:ACBD
2557:NMDA
2523:AMAA
2423:NBQX
2398:GAMS
2393:DNQX
2383:CNQX
2301:ATPA
2296:AMPA
2134:PNQX
2129:NBQX
2104:GAMS
2094:DNQX
2084:CNQX
2069:ATPO
2029:PEPA
1887:BOAA
1882:AMPA
1706:GluD
1641:NMDA
1571:AMPA
1529:Zinc
1515:(α1)
1506:(β4)
1502:(α1)
1494:(α7)
1486:(β2)
1482:(α4)
1474:(β4)
1470:(α3)
1289:GABA
1163:GABA
1155:GABA
1115:5-HT
1013:PMID
961:PMID
915:PMID
855:PMID
820:PMID
771:PMID
720:PMID
671:PMID
611:PMID
573:PMID
510:PMID
412:DNQX
407:CNQX
368:ATPA
342:cell
278:NMDA
276:and
274:AMPA
236:and
228:The
146:GluR
133:GluR
120:GluR
108:GABA
90:and
88:AMPA
80:NMDA
57:KARs
2934:ACC
2842:CPP
2812:AP7
2623:CCG
2263:KAR
1759:P2X
1738:ATP
1686:L1B
1681:L1A
1430:α10
1003:doi
991:291
951:doi
905:PMC
897:doi
847:doi
810:PMC
802:doi
761:hdl
751:doi
710:PMC
702:doi
661:PMC
653:doi
603:doi
563:PMC
555:doi
195:5-7
183:5-7
169:KA2
159:KA1
157:),
144:),
131:),
3868::
3683:;
3571:;
3554:;
3532:;
3468:;
3096:;
3064:;
2914:;
2732:24
2727:;
2710:;
2579:;
2466:,
2455:;
2343:;
2247:;
2177:,
2166:;
1919:;
1676:3B
1671:3A
1666:2D
1661:2C
1656:2B
1651:2A
1450:β4
1445:β3
1440:β2
1435:β1
1425:α9
1420:α7
1415:α6
1410:α5
1405:α4
1400:α3
1395:α2
1390:α1
1293:-ρ
1088::
1084:,
1019:.
1011:.
1001:.
989:.
985:.
973:^
959:.
947:45
945:.
941:.
927:^
913:.
903:.
893:20
891:.
887:.
861:.
853:.
843:25
841:.
818:.
808:.
798:17
796:.
792:.
769:.
759:.
747:80
745:.
741:.
718:.
708:.
698:34
696:.
692:.
669:.
659:.
649:34
647:.
643:.
631:^
617:.
609:.
599:70
597:.
585:^
571:.
561:.
551:56
549:.
545:.
506:51
504:.
500:.
320:,
316:,
312:,
308:,
301:.
242:pS
3807:)
3803:(
3709:D
2975:D
2765:)
2761:(
2752:)
2748:(
2734:S
2686:L
2678:L
2645:D
2637:D
2629:D
2586:D
2540:L
2470:)
2181:)
1834:e
1827:t
1820:v
1794:7
1789:6
1784:5
1779:4
1774:3
1769:2
1764:1
1740:-
1721:2
1719:δ
1713:1
1711:δ
1646:1
1621:5
1616:4
1611:3
1606:2
1601:1
1592:)
1590:4
1585:3
1580:2
1575:1
1573:(
1517:2
1508:3
1504:2
1496:5
1488:3
1484:2
1476:3
1472:2
1460:ε
1455:δ
1369:β
1363:4
1361:α
1355:3
1353:α
1347:2
1345:α
1339:1
1337:α
1316:3
1314:ρ
1308:2
1306:ρ
1300:1
1298:ρ
1291:A
1282:θ
1277:π
1272:ε
1267:δ
1261:3
1259:γ
1253:2
1251:γ
1245:1
1243:γ
1237:3
1235:β
1229:2
1227:β
1221:1
1219:β
1213:6
1211:α
1205:5
1203:α
1197:4
1195:α
1189:3
1187:α
1181:2
1179:α
1173:1
1171:α
1165:A
1143:E
1138:D
1133:C
1128:B
1123:A
1117:3
1074:e
1067:t
1060:v
1027:.
1005::
997::
967:.
953::
921:.
899::
869:.
849::
826:.
804::
777:.
763::
753::
726:.
704::
677:.
655::
625:.
605::
579:.
557::
530:.
191:6
187:5
171:(
161:(
151:(
148:7
138:(
135:6
125:(
122:5
55:(
20:)
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