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Katharina Ribbeck

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31: 415:"The intention here is to really introduce a field to the generations to come, so they grow up understanding that mucus is not a waste product. It's an integral part of our physiology and a really important piece of our health. If we understand it, it can really give us a lot of information that will help us stay healthy and possibly treat diseases." (Ribbeck, 2018) 204: 192: 180: 168: 156: 144: 315:
In 2007, Ribbeck's research returned to hydrogels, with a specific focus on mucus, i.e., a large natural hydrogel that is closely related to the polymer network she and Görlich had proposed to exist within nuclear pore complexes. Her work has elucidated the role of mucins, a primary component of
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As a postdoctoral researcher at the European Molecular Biology Laboratory, Ribbeck studied proteins involved in the organization of the mitotic spindle, a dynamic bundle consisting of proteins and molecules that aids in chromosome segregation during cell division. Her research contributed to the
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mucus, in human health. Ribbeck is known for her pioneering work in this field, which has shown that mucus plays an active role in protecting against harmful pathogens, including fungi, bacteria, and viruses. Specifically, her research has shown that mucins and their associated sugar chains (
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Takagi, Julie; Aoki, Kazuhiro; Turner, Bradley S.; Lamont, Sabrina; Lehoux, Sylvain; Kavanaugh, Nicole; Gulati, Megha; Valle Arevalo, Ashley; Lawrence, Travis J.; Kim, Colin Y.; Bakshi, Bhavya; Ishihara, Mayumi; Nobile, Clarissa J.; Cummings, Richard D.; Wozniak, Daniel J. (July 2022).
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barrier. With her Ph.D. advisor, Dirk Görlich, Ribbeck developed a selective phase model for molecular transport through the nuclear pore barrier. Görlich and Ribbeck also showed that molecular transport through nuclear pore complexes may be facilitated by hydrophobic interactions.
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Ribbeck, Katharina; Groen, Aaron C.; Santarella, Rachel; Bohnsack, Markus T.; Raemaekers, Tim; Köcher, Thomas; Gentzel, Marc; Görlich, Dirk; Wilm, Matthias; Carmeliet, Geert; Mitchison, Timothy J.; Ellenberg, Jan; Hoenger, Andreas; Mattaj, Iain W. (2006-06-01).
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Ribbeck's work has also demonstrated the role of mucus in protecting against fungal infections. Her studies have shown that mucins and specific mucin glycans induce a morphological change, accompanied by a reduction in biofilm formation and cell adhesion, in
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Ribbeck has investigated approaches for engineering mucus, with the aim of potentially influencing the population of bacteria in the human body. In collaboration with others, Ribbeck demonstrated that synthetic mucins can block toxins produced by
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Kruger, Austin G.; Brucks, Spencer D.; Yan, Tao; Cárcarmo-Oyarce, Gerardo; Wei, Yuan; Wen, Deborah H.; Carvalho, Dayanne R.; Hore, Michael J. A.; Ribbeck, Katharina; Schrock, Richard R.; Kiessling, Laura L. (2021-04-28).
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Wheeler, Kelsey M.; Cárcamo-Oyarce, Gerardo; Turner, Bradley S.; Dellos-Nolan, Sheri; Co, Julia Y.; Lehoux, Sylvain; Cummings, Richard D.; Wozniak, Daniel J.; Ribbeck, Katharina (December 2019).
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Raemaekers, Tim; Ribbeck, Katharina; Beaudouin, Joël; Annaert, Wim; Van Camp, Mark; Stockmans, Ingrid; Smets, Nico; Bouillon, Roger; Ellenberg, Jan; Carmeliet, Geert (September 8, 2003).
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Werlang, Caroline A.; Chen, Wesley G.; Aoki, Kazuhiro; Wheeler, Kelsey M.; Tymm, Carly; Mileti, Cassidy J.; Burgos, Ana C.; Kim, Kris; Tiemeyer, Michael; Ribbeck, Katharina (May 2021).
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Studies on the role of mucus in human health, mucus’ influence on the behavior of harmful pathogens, and the molecular mechanism by which the nuclear pore mediates selective transport
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Ribbeck, K.; Kutay, U.; Paraskeva, E.; Görlich, D. (1999-01-14). "The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy".
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Critchfield, Agatha S.; Yao, Grace; Jaishankar, Aditya; Friedlander, Ronn S.; Lieleg, Oliver; Doyle, Patrick S.; McKinley, Gareth; House, Michael; Ribbeck, Katharina (2013).
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Ribbeck is passionate about educating others on the importance of mucus in human health. Together with her lab, she gives presentation about her work on mucus at the
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in pregnant women and the likelihood of preterm birth and has developed probes to test mucus permeability as a step towards diagnosing the risk for premature birth.
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In 2015, Ribbeck and her team produced a TED-Ed lesson to provide basic education about mucus and its role in human health. Ribbeck has been interviewed on
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as a barrier to pathogens such as fungi, bacteria, and viruses and how mucus can be leveraged for therapeutic purposes. She has also studied changes that
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Wang, Benjamin X.; Wheeler, Kelsey M.; Cady, Kyle C.; Lehoux, Sylvain; Cummings, Richard D.; Laub, Michael T.; Ribbeck, Katharina (2021-01-11).
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Billings, Nicole; Millan, MariaRamirez; Caldara, Marina; Rusconi, Roberto; Tarasova, Yekaterina; Stocker, Roman; Ribbeck, Katharina (2013).
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Smith-Dupont, K. B.; Wagner, C. E.; Witten, J.; Conroy, K.; Rudoltz, H.; Pagidas, K.; Snegovskikh, V.; House, M.; Ribbeck, K. (2017-09-04).
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as an independent Bauer Fellow in 2007, where she began to investigate how particles and bacteria move through mucus barriers.
2566:"NSF Award Search: Award#1454673 - Career: Selective Transport in Biological Hydrogels – From Design Principles to Mechanisms" 2491: 373:
properties of mucus and other hydrogels and the mechanisms by which some particles and molecules, including viruses such as
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Kavanaugh, Nicole L.; Zhang, Angela Q.; Nobile, Clarissa J.; Johnson, Alexander D.; Ribbeck, Katharina (2014-11-11).
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is a German-American biologist. She is the Andrew (1956) and Erna Viterbi Professor of Biological Engineering at the
2720: 2137:"The extracellular matrix Component Psl provides fast-acting antibiotic defense in Pseudomonas aeruginosa biofilms" 408: 2685: 1768: 183: 1193:
Li, Leon D.; Crouzier, Thomas; Sarkar, Aniruddh; Dunphy, Laura; Han, Jongyoon; Ribbeck, Katharina (2013-09-17).
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Chen, Wesley G.; Witten, Jacob; Grindy, Scott C.; Holten-Andersen, Niels; Ribbeck, Katharina (2017-11-07).
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Lieleg, Oliver; Lieleg, Corinna; Bloom, Jesse; Buck, Christopher B.; Ribbeck, Katharina (2012-06-11).
2207: 2026: 1880: 1813: 1596:"Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans" 1452: 1271: 1206: 841: 755: 378: 335: 290: 1195:"Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier" 688: 2675: 2443: 1326: 721: 633: 234:
mucus undergoes before birth, which may lead to a novel diagnostic for the risk of preterm birth.
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discovery of a novel protein (NuSAP) that plays a crucial role in mitotic spindle organization.
1932: 250:, to study neurobiology for her diploma thesis. She earned her Ph.D. in biology, also from the 207: 2403: 2385: 2346: 2328: 2280: 2272: 2223: 2176: 2158: 2109: 2101: 2060: 2042: 1995: 1977: 1914: 1896: 1849: 1831: 1776: 1746: 1728: 1633: 1615: 1549: 1531: 1486: 1468: 1418: 1400: 1305: 1287: 1240: 1222: 1166: 1117: 1099: 1059: 1041: 989: 981: 940: 922: 875: 867: 789: 771: 1021: 289:
During her Ph.D. work, Ribbeck investigated the selective transport of molecules through the
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Upon completing her Ph.D., Ribbeck continued her research as a postdoctoral scientist at the
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Samad, Tahoura; Witten, Jacob; Grodzinsky, Alan J.; Ribbeck, Katharina (2022-01-18).
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Werlang, Caroline; Cárcarmo-Oyarce, Gerardo; Ribbeck, Katharina (February 2019).
2153: 1826: 1352:"Not as Gross as It Sounds: Predicting How Bacteria in Mucus Affect Human Health" 499: 117: 2324: 1892: 1611: 1527: 918: 2670: 2421: 2219: 2038: 1464: 1396: 1381:"Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection" 1283: 1218: 1037: 767: 404: 374: 370: 147: 2389: 2332: 2276: 2227: 2162: 2105: 2046: 1981: 1900: 1835: 1780: 1732: 1619: 1535: 1472: 1404: 1291: 1226: 1103: 1080:"NuSAP, a Mitotic RanGTP Target That Stabilizes and Cross-links Microtubules" 1045: 985: 926: 871: 775: 1095: 281:
as an assistant professor. She attained tenure as a full professor in 2017.
2407: 2350: 2284: 2180: 2113: 2064: 1999: 1918: 1869:"Probing the potential of mucus permeability to signify preterm birth risk" 1853: 1750: 1637: 1553: 1490: 1422: 1309: 1244: 1170: 1121: 1063: 993: 944: 793: 1958:"The particle in the spider's web: transport through biological hydrogels" 1724: 1512:"Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity" 1152: 879: 277:
In 2010, Ribbeck moved to the Department of Biological Engineering at the
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Ribbeck identified a correlation between the properties of mucus in the
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impacts microbial behavior. Ribbeck investigates both the function of
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Harvard University - Department of Molecular & Cellular Biology
500:"Katharina Ribbeck, PhD | MIT Department of Biological Engineering" 99:
Mechanistic analysis of transport through the nuclear pore complex
2468:"Aus der Stiftung Universität Heidelberg - Universität Heidelberg" 2251:"Mucins and Their Role in Shaping the Functions of Mucus Barriers" 2080:"Mucins and Their Role in Shaping the Functions of Mucus Barriers" 1022:"Kinetic analysis of translocation through nuclear pore complexes" 742:
Lieleg, Oliver; Vladescu, Ioana; Ribbeck, Katharina (2010-05-19).
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and STAT news and has been featured in articles in WIRED and
222:. She is known as one of the first researchers to study how 2681:
STAT News: Why mucus is the ‘unsung hero’ of the human body
1802:"Cervical mucus properties stratify risk for preterm birth" 172:
STAT News: Why mucus is the ‘unsung hero’ of the human body
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WIRED: How the Sugars in Spit Tame the Body's Unruly Fungi
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WIRED: How the Sugars in Spit Tame the Body’s Unruly Fungi
2196:"Engineering mucus to study and influence the microbiome" 558:"WATCH: Why mucus is the 'unsung hero' of the human body" 2492:"Merck Presents 2007 Awards for Genome-Related Research" 2249:
Wagner, C.E.; Wheeler, K.M.; Ribbeck, K. (2018-10-06).
2366:"Mucin biopolymers as broad-spectrum antiviral agents" 2309:"Stereochemical Control Yields Mucin Mimetic Polymers" 1709:"Mucins suppress virulence traits of Candida albicans" 1327:"Molecules found in mucus can thwart fungal infection" 1769:"How the Sugars In Spit Tame the Body's Unruly Fungi" 456:
2015: Junior Bose Award for Excellence in Teaching (
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2016: Harold E. Edgerton Faculty Achievement Award (
339:, the bacteria that cause tooth decay, from forming 2078:Wagner, C. E.; Wheeler, K. M.; Ribbeck, K. (2018). 609:"Synthetic Mucus Helps Fight Antibiotic Resistance" 583:"Mucus Is Beneficial In The Fight Against Bacteria" 136: 108: 92: 78: 70: 55: 47: 37: 21: 246:in 1998. During her senior year, she attended the 1956:Witten, Jacob; Ribbeck, Katharina (2017-06-22). 1687:MIT News | Massachusetts Institute of Technology 1331:MIT News | Massachusetts Institute of Technology 1020:Ribbeck, Katharina; Görlich, Dirk (2001-03-15). 901:Ribbeck, Katharina; Görlich, Dirk (2002-06-03). 812:MIT News | Massachusetts Institute of Technology 693:MIT News | Massachusetts Institute of Technology 270:. After her postdoctoral research, she moved to 2517:"Alumni Awards - The John Kendrew Award - EMBL" 2255:Annual Review of Cell and Developmental Biology 2084:Annual Review of Cell and Developmental Biology 2614:"Harold E. Edgerton Faculty Achievement Award" 2423:How mucus keeps us healthy - Katharina Ribbeck 242:Ribbeck received her B.S. in biology from the 470:2018: Professor Amar G. Bose Research Grant ( 8: 385:protects the bacterium against antibiotics. 2691:MIT Technology Review: The science of slime 196:MIT Technology Review: The science of slime 16:German-American biochemist and biophysicist 1571:"Synthetic Mucus Can Mimic the Real Thing" 18: 2397: 2340: 2266: 2170: 2152: 2095: 2054: 1989: 1908: 1843: 1825: 1740: 1627: 1543: 1480: 1412: 1299: 1234: 1160: 1111: 1053: 975: 934: 861: 783: 436:2007: Award for Genome-Related Research ( 369:Ribbeck has extensively investigated the 2676:Science Friday: It's snot what you think 1683:"Study reveals how mucus tames microbes" 160:Science Friday: It's snot what you think 484: 2726:21st-century American women scientists 1762: 1760: 1677: 1675: 1565: 1563: 1504: 1502: 1500: 208:MIT Spectrum: A slippery viral defense 133: 2756:German emigrants to the United States 2671:How mucus keeps you healthy (YouTube) 2268:10.1146/annurev-cellbio-100617-062818 2097:10.1146/annurev-cellbio-100617-062818 1649: 1647: 1434: 1432: 1374: 1372: 1321: 1319: 1188: 1186: 1015: 1013: 1011: 450:2014: Popular Science, "Brilliant 10" 279:Massachusetts Institute of Technology 264:European Molecular Biology Laboratory 220:Massachusetts Institute of Technology 83:Massachusetts Institute of Technology 7: 683: 681: 679: 677: 552: 550: 525: 523: 521: 519: 494: 492: 490: 488: 1575:The MIT Campaign for a Better World 689:"Exploring the many roles of mucus" 381:formed by the pathogenic bacterium 248:University of California, San Diego 960:"Passage through the nuclear pore" 323:She has shown that mucins prevent 285:Research on nuclear pore complexes 148:TED-Ed: How mucus keeps us healthy 14: 2716:MIT School of Engineering faculty 2444:"Mucus: It's Snot What You Think" 266:in Heidelberg, Germany, and then 51:University of Heidelberg, Germany 2741:21st-century American physicists 293:, which is partly mediated by a 202: 190: 178: 166: 154: 142: 29: 1656:"Mucus: The Body's Unsung Hero" 808:"The tenured engineers of 2017" 2731:21st-century American chemists 863:11858/00-001M-0000-002D-1CB6-0 1: 1084:Molecular Biology of the Cell 854:10.1016/S0960-9822(99)80046-3 2736:Heidelberg University alumni 2154:10.1371/journal.ppat.1003526 1827:10.1371/journal.pone.0069528 958:Marte, Barbara (June 2001). 607:Walter, Kenny (2017-04-27). 302:Research on mitotic spindles 2541:"The Brilliant Ten of 2014" 430:2003: Ruprecht-Karls Prize 2772: 2618:MIT Institutional Research 2325:10.1021/acscentsci.0c01569 1933:"A Slippery Viral Defense" 1893:10.1038/s41598-017-08057-z 1612:10.1038/s41564-021-00876-1 1528:10.1038/s41589-022-01035-1 613:Research & Development 443:2013: John Kendrew Award ( 2746:Scientists from Darmstadt 2220:10.1038/s41578-018-0079-7 2039:10.1016/j.bpj.2017.08.058 1465:10.1016/j.cub.2020.09.088 1397:10.1038/s41564-019-0581-8 1284:10.1016/j.bpj.2021.12.018 1219:10.1016/j.bpj.2013.07.050 768:10.1016/j.bpj.2010.01.012 201: 189: 177: 165: 153: 141: 128: 63: 28: 2751:American women academics 2200:Nature Reviews Materials 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Index


Massachusetts Institute of Technology
Harvard University
Thesis
Tim Mitchison
Iain Mattaj
Andrew Murray
TED-Ed: How mucus keeps us healthy
Science Friday: It's snot what you think
STAT News: Why mucus is the ‘unsung hero’ of the human body
WIRED: How the Sugars in Spit Tame the Body’s Unruly Fungi
MIT Technology Review: The science of slime
MIT Spectrum: A slippery viral defense
Massachusetts Institute of Technology
mucus
mucus
cervical
University of Heidelberg
University of California, San Diego
University of Heidelberg
European Molecular Biology Laboratory
Harvard Medical School
Harvard University
Massachusetts Institute of Technology
nuclear pore complex
hydrogel
glycans
bacteria
Pseudomonas aeruginosa
Streptococcus mutans

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