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data, publicly presented at a special meeting of the Tokyo
Medical Society and reprinted below, focused attention on chemical carcinogenesis. Further more, his experimental method provided researchers with a means of producing cancer in the laboratory and anticipated investigation of specific carcinogenic agents and the precise way in which they acted. Within a decade, Keller and associates extracted a highly potent carcinogenic hydrocarbon from coal tar. Dr. Yamagiwa had begun a new era in cancer research.
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explores the candidacy of
Yamagiwa, who had developed the world's first efficient method for producing cancer artificially in the laboratory by swabbing coal tar on rabbits' ears, which had stimulated activity among cancer researchers worldwide. Johannes Fibiger of Denmark, who discovered how to use
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Yamagiwa, then
Director of the Department of Pathology at Tokyo Imperial University Medical School, had theorized that repetition or continuation of chronic irritation caused precancerous alterations in previously normal epithelium. If the irritant continued its action, carcinoma could result. These
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parasites to cause cancer in rats two years before
Yamagiwa's achievement, received the prize, probably because nominations were often greatly influenced by acquaintanceship, geography, and the marginalization that distance from other centers imposed on the Japanese.
337:
on the inner surface of rabbits' ears. Yamagiwa's work has become the primary basis for this line of research. Because of this, some people consider
Fibiger's Nobel Prize to be undeserved, particularly because Yamagiwa never received the prize for his work.
329:, a microbial parasite which Fibiger claimed was the cause of cancer. This "finding" was discredited by other scientists shortly thereafter. Two years later, Katsusaburo Yamagiwa successfully induced
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238:. He became the adopted son-in-law of Yoshiya Yamagiwa, a physician in Katsuya, Tokyo, and took the surname Yamagiwa. He completed his MD in 1888 from
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408:"Gist of Dr. Katsusaburo Yamagiwa's papers entitled "Experimental study on the pathogenesis of epithelial tumors" (I to VI reports)"
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Stolt CM, Klein G, Jansson AT (2004). "An analysis of a wrong Nobel Prize-Johannes
Fibiger, 1926: a study in the Nobel archives".
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135:
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320:
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Stolley PD, Lasky T (1992). "Johannes
Fibiger and his Nobel Prize for the hypothesis that a worm causes stomach cancer".
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242:. He was appointed as a professor at the Medical School, Imperial University of Tokyo and published his landmark work,
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I.M. Modlin; M. Kidd; T. Hinoue (2001). "Of
Fibiger and fables: a cautionary tale of cockroaches and
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Petithory JC, Théodoridès J, Brumpt L (1997). "A challenged Nobel Prize: Johannes
Fibiger, 1926".
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Clemmesen J (1978). "Johannes
Fibiger. Gongylonema and vitamin A in carcinogenesis".
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803:"Katsusaburo Yamagiwa's Nobel candidacy: Physiology or medicine in the 1920s"
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advocated that Yamagiwa deserved the Nobel Prize, but it was not realized.
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In a series of experiments conducted in 1915, Yamagiwa and his assistant
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266:, was first issued by him. In addition, he and his colleagues found the
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Yamagiwa extensively promoted cancer research in Japan. In 1907
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505:(in Japanese). Tokyo: Shogakukan. 2012. Archived from
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206:who carried out pioneering work into the causes of
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230:, the third son of the feudal retainer of the
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210:, and was the first to demonstrate chemical
527:Katsusaburo Yamagiwa - Nomination Database
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867:Academic staff of the University of Tokyo
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548:(in Japanese). Tokyo: Shogakukan. 2012.
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268:Japanese Foundation for Cancer Research
27:Japanese medical scientist (1863–1930)
341:In 1966, the former committee member
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760:CA: A Cancer Journal for Clinicians
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756:"Katsusaburo Yamagiwa (1863–1930)"
546:Nihon Daihyakka Zensho (Nipponika)
200:, 23 February 1863 – 2 March 1930)
25:
580:Acta Pathol Microbiol Scand Suppl
308:Yamagiwa and Ichikawa shared the
857:20th-century Japanese physicians
852:19th-century Japanese physicians
689:10.1097/00004836-200109000-00001
544:[Yamagiwa Katsusaburō].
501:[Katsusaburō Yamagiwa].
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369:
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42:
714:. Advances in Cancer Research.
847:Deaths from pneumonia in Japan
1:
872:People from Nagano Prefecture
724:10.1016/S0065-230X(04)92001-5
321:Johannes Andreas Grib Fibiger
296:on the ears of rabbits using
240:Imperial University of Tokyo
615:10.7326/0003-4819-116-9-765
465:. Tokyo: Shogakukan. 2012.
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862:University of Tokyo alumni
289:(1888–1948) induced
277:in 1930 at the age of 67.
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773:10.3322/canjclin.27.3.172
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164:Tokyo Imperial University
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115:Tokyo Imperial University
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312:in 1919 for their work.
331:squamous cell carcinoma
323:, for his discovery of
459:"Katsusaburō Yamagiwa"
827:Japanese pathologists
800:Bartholomew, James R.
503:Nihon Jinmei Daijiten
463:Encyclopedia of Japan
262:covering research in
226:Yamagiwa was born in
766:(3): 172–173. 1977.
677:J Clin Gastroenterol
326:Spiroptera carcinoma
273:He died in Tokyo of
191:Yamagiwa Katsusaburō
48:Yamagiwa Katsusaburō
34:Yamagiwa Katsusaburō
18:Katsusaburō Yamagiwa
673:Helicobacter pylori
310:Japan Academy Prize
136:Japan Academy Prize
832:Cancer researchers
406:Fujiki, H (2014).
333:by painting crude
214:. He was a 7-time
424:10.1111/cas.12333
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144:Scientific career
76:Nagano Prefecture
16:(Redirected from
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236:Shinano Province
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363:Japan portal
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228:Ueda, Nagano
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160:Institutions
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89:(1930-03-02)
87:2 March 1930
842:1930 deaths
837:1863 births
718:(1): 1–12.
317:Nobel Prize
246:, in 1895.
232:Ueda Domain
216:Nobel Prize
204:pathologist
103:Nationality
821:Categories
564:2012-11-08
513:2012-11-08
481:2012-11-08
349:References
294:carcinomas
60:1863-02-23
554:153301537
315:The 1926
275:pneumonia
270:in 1908.
218:nominee.
154:Pathology
124:Chemical
742:15530554
697:11500602
658:11625107
631:32269200
542:"山極 勝三郎"
499:"山極 勝三郎"
471:56431036
442:24313817
335:coal tar
319:went to
298:coal tar
264:oncology
185:Yamagiwa
175:In this
106:Japanese
78:), Japan
623:1558350
433:4317818
181:surname
97:, Japan
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208:cancer
197:山極 勝三郎
179:, the
150:Fields
138:, 1919
132:Awards
36:山極 勝三郎
627:S2CID
95:Tokyo
74:(now
778:PMID
738:PMID
728:ISBN
693:PMID
654:PMID
619:PMID
584:PMID
550:OCLC
467:OCLC
438:PMID
222:Life
84:Died
68:Ueda
54:Born
768:doi
720:doi
685:doi
675:".
611:doi
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428:PMC
420:doi
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234:in
183:is
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