309:"Eggan's technique provides a window into exactly what happens to turn back the clock in cells during cloning--and, indeed, in the normal process of creating sperm, eggs and embryos. Somehow, aging is reversed, and old cells become young again. As Schatten puts it, the one-way freeway of life has an exit ramp. Understanding what happens when the cell is reprogrammed is one of the main goals of studying embryonic stem cells. But right now, the only way to solve that problem is to clone embryos, which is a difficult and expensive process.
323:
The hybrids still contain two nuclei: one from a skin cell and one from an embryonic stem cell. So they have an abnormally high amount of DNA, and Eggan needs to work out how to remove the embryonic stem cell's DNA. Eggan adds that he has only just begun working with the hybrids, so it is not clear
293:
Eggan's work as of 2007 has succeeded in developing a technique of merging stem and skin cells that has obtained considerable public attention as a possible avenue to avoid moral objections regarding stem cell research in the context of serious illness. It suggests that ultimately, treatment of
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Eggan began to explore both this process and also the reasons that cloned animals often appeared to develop abnormally, with organ defects and immunological problems – his first contact with stem cell research. After finishing his PhD in 2002, Eggan split his time between a post-doctoral
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techniques to create disease-specific stem cell lines as an approach to various currently incurable conditions. Eggan was in charge of one of these two groups and senior author of their results; a renowned co-director of HSCI ran the other. The groups initially collaborated in researching
234:, and research such as this was at risk of potentially being made illegal. Federal funding for stem cell research had recently been removed, and part of his role was to obtain private funding to replace it. Eggan took on a second role as the assistant investigator for
294:
serious illnesses and understanding of stem cell development may be possible to obtain without recourse to human embryos – a highly desirable state of affairs politically, given the concurrent controversy over stem cell research in the United States.
305:, with opponents of the use of embryonic stem cells from fetuses arguing that these or similar methods of creating stem cells from skin might be eventually used instead to satisfy the conflicting demands of medical research and morals.
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Eggan, K; Akutsu, H; Loring, J; Jackson-Grusby, L; Klemm, M; Rideout, WM; Yanagimachi, R; Jaenisch, R. "Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation,"
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Humphreys, D; Eggan, K; Akutsu, H; Friedman, A; Hochedlinger, K; Yanagimachi, R; Lander, ES; Golub, TR; Jaenisch, R. "Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei."
324:
what they will or won't be able to do. "It's frustrating," Eggan says, "because they're implying that our work is a solution, which it is not yet. These are ideas in their most nascent stages."
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Bortvin, A; Eggan, K; Skaletsky, H; Akutsu, H; Berry, DL; Yanagimachi, R; Page, DC; Jaenisch, R. "Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei"
337:"Eggan is also becoming one of science's more outspoken voices, defending the necessity of pursuing embryonic cell research through all available means as a way of understanding scourges ."
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at their Stem Cell
Institute ("HSCI") in 2005. At the time, stem cell research in the United States was threatened by political pressure due to concerns over the ethics of
776:"Stem-cell research: The rocky road to success Tackling the legal and ethical minefield associated with human embryonic stem-cell research is not for the faint-hearted"
350:
Humpherys, D; Eggan, K; Akutsu, H; Hochedlinger, K; Rideout, WM; Biniszkiewicz, D; Yanagimachi, R; Jaenisch, R. "Epigenetic instability in ES cells and cloned mice":
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265:. In 2006, following "more than two years of intensive ethical and scientific review", two groups of scientists at HSCI were granted permission to explore
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Winner of Harold M. Weintraub
Graduate Student Award in 2003 sponsored by the Basic Sciences Division of the Fred Hutchinson Cancer Research Center
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301:, a major step toward someday possibly defusing the central objection to stem cell research. These discoveries sparked extensive debate in the
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686:"Approval granted for Harvard Stem Cell Institute researchers to attempt creation of disease-specific embryonic stem cell lines"
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Eggan's team reported that they had created cells similar to human embryonic stem cells without destroying
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112:"), and as a spokesperson for stem cell research in the United States. He was a 2006 recipient of a
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143:, the son of Chris and Larry Eggan and one of five children, his father being a math professor at
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Rideout, WM; Eggan, K; Jaenisch, R. "Nuclear cloning and epigenetic reprogramming of the genome.
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https://www.boston.com/news/science/articles/2006/07/03/he_sees_stem_cells_as_a_solution/
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Eggan also served as the Chief
Scientific Officer of The New York Stem Cell Foundation.
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Eggan himself is cautious about his team's work, with an early stage 2005 profile in
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655:"Stem Cell Advance Muddles Debate; Work May Stall Efforts To Lift Research Limits"
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works, and to make stem cells that carry genes for specific diseases such as
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716:"Harvard scientists advance cell work; technique doesn't destroy embryos"
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116:(sometimes nicknamed the "genius grant"). In 2005, he was named to the
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Harvard
University Department of Molecular and Cellular Biology News
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as one of the top 35 innovators in the world under the age of 35.
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Honored in
Popular Science's fourth annual "Brilliant 10" in 2005
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949:
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Massachusetts
Institute of Technology School of Science alumni
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Technology Review
Magazine's "Innovator of the Year" in 2005
100:) is a Professor of Stem Cell and Regenerative Biology at
864:"Kevin Eggan Wins Harold M. Weintraub Grad Student Award"
245:
Eggan's research goals at
Harvard were to understand how
226:, as a junior fellow, becoming an assistant professor of
16:
American
Professor of Stem Cell and Regenerative Biology
459:
Biologist Kevin Eggan: He sees stem cells as a solution
625:"P.C. Stem Cells; Kevin Eggan, 32 Cellular Biologist"
381:, 98 (11): 6209-6214, May 22, 2001. Times Cited: 191
77:
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50:
42:
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21:
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680:
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346:Eggan's five most highly cited publications are:
178:gained worldwide attention as the world's first
388:Proceedings of the National Academy of Sciences
378:Proceedings of the National Academy of Sciences
985:University of Illinois Urbana-Champaign alumni
238:, a philanthropical medical research group in
1005:Stowers Institute for Medical Research people
595:"Kevin Eggan: Steps Towards Stemming Disease"
490:"B-N native awarded MacArthur 'genius' grant"
450:
448:
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444:
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166:. In 1998 he applied to study for a Ph.D. in
8:
744:Elisabeth Eaves; Michael Noer (2007-05-24).
564:"Stem Cells: Promise, in Search of Results"
548:B-N native awarded MacArthur 'genius' grant
484:
482:
333:Forbes noted in Eggan's 2007 profile that:
714:Gareth Cook; Carey Goldberg (2005-08-22).
429:People Magazine's "Sexiest Genius" in 2006
150:After completing his bachelor's degree in
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274:before Eggan's group switched to work on
319:noting there was still much work to do:
282:called the approvals "a seminal event".
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236:Stowers Institute for Medical Research
172:Massachusetts Institute of Technology
7:
955:Nuclear Transfer into Mouse Oocytes
922:. November 27, 2006. Archived from
206:, as well as spending time at the
14:
194:and a collaborative project with
975:21st-century American biologists
511:"2005 Young Innovators Under 35"
356:, 293 (5527): 95-97 JUL 6 2001,
228:Molecular & Cellular Biology
391:, 99 (20): 12889-12894 (2002).
368:, 293 (5532): 1093-1098 (2001).
218:In August 2004, Eggan moved to
204:Howard Hughes Medical Institute
174:, arriving there shortly after
888:Marissa Newhall (2005-09-13).
833:"Turning Skin Into Stem Cells"
690:The Harvard University Gazette
538:- "four sisters and a brother.
1:
831:Matthew Helper (2005-08-23).
623:Matthew Herper (2007-05-24).
401:, 130 (8): 1673-1680 (2003)
267:Somatic Cell Nuclear Transfer
255:amyotrophic lateral sclerosis
164:National Institutes of Health
1010:People from Normal, Illinois
692:. 2006-06-06. Archived from
653:Ceci Connolly (2005-08-23).
950:Harvard Stem Cell Institute
890:"'Brilliant' minds honored"
455:Andrew Rimas (2006-07-03).
1026:
980:Harvard University faculty
774:Erika Check (2004-09-07).
276:neurodegenerative diseases
202:–winning scientist at the
945:Stowers Medical Institute
424:MacArthur Fellows Program
145:Illinois State University
108:research (also known as "
87:
60:
224:Cambridge, Massachusetts
135:Background and education
104:, known for his work in
247:nuclear transplantation
303:United States Congress
156:University of Illinois
746:"The Revolutionaries"
240:Kansas City, Missouri
232:human embryo research
926:on October 30, 2008.
329:Work as spokesperson
278:. Harvard President
259:Lou Gehrig's disease
208:University of Hawaii
114:MacArthur Fellowship
845:on January 14, 2006
660:The Washington Post
251:Parkinson's disease
110:therapeutic cloning
576:on August 31, 2005
569:The New York Times
497:via pantagraph.com
220:Harvard University
214:Stem cell research
102:Harvard University
72:Harvard University
1000:MacArthur Fellows
788:(7056): 185–186.
515:Technology Review
182:domestic animal.
139:Eggan grew up in
121:Technology Review
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62:Scientific career
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916:"Feel the heat!"
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403:Times Cited: 143
393:Times Cited: 157
370:Times Cited: 250
358:Times Cited: 288
280:Lawrence Summers
141:Normal, Illinois
98:Normal, Illinois
79:Doctoral advisor
36:Normal, Illinois
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196:Richard Axel
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152:microbiology
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93:
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68:Institutions
61:
970:1975 births
560:Gina Kolata
399:Development
263:Alzheimer's
200:Nobel Prize
94:Kevin Eggan
43:Nationality
23:Kevin Eggan
964:Categories
901:2007-09-04
874:2007-09-02
849:2007-09-04
817:2007-09-04
757:2007-09-04
727:2007-09-04
700:2007-09-04
666:2007-09-04
636:2007-09-04
609:2007-09-04
580:2007-09-04
521:August 15,
472:2007-09-04
434:References
895:USA Today
130:Biography
106:stem cell
55:stem cell
804:16148905
272:diabetes
190:pioneer
188:genetics
46:American
812:4391808
365:Science
353:Science
299:embryos
261:), and
170:at the
168:biology
162:at the
154:at the
838:Forbes
810:
802:
781:Nature
751:Forbes
630:Forbes
517:. 2005
409:Awards
316:Nature
180:cloned
808:S2CID
160:Amgen
800:PMID
523:2011
426:2006
198:, a
124:TR35
32:1974
29:Born
790:doi
786:437
222:in
118:MIT
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