752:. When compared with placebo for treating immune mediated inflammation post transplantation and in autoimmunity, mesenchymal stromal cells (MSCs) may reduce the all-cause mortality if they are used for a therapeutic reason. Moreover, the therapeutic use of MSCs may increase the complete response of acute and chronic GvHD, but the evidence is very uncertain. The evidence suggests that MSCs for prophylactic reason result in little to no difference in the all-cause mortality, in the relapse of malignant diseases, and in the incidence of acute GvHD. The evidence suggests that MSCs for prophylactic reason reduce the incidence of chronic GvHD.
53:
426:, weight loss, and tiredness. Other symptoms may include bone pain, chest pain, or itchiness. Some forms are slow growing, while others are fast growing. Enlarged lymph nodes may cause lumps to be felt under the skin when they are close to the surface of the body. Lymphomas in the skin may also result in lumps, which are commonly itchy, red, or purple. Lymphomas in the brain can cause weakness, seizures, problems with thinking, and personality changes.
759:
bleeding and they may result in a slight reduction in the number of days on which a significant bleeding event occurred. The evidence suggests that therapeutic platelet transfusions result in a large increase in the number of people with at least one significant bleeding event and they likely result in a large reduction in the number of platelet transfusions.
689:(CDC) included certain types of non-Hodgkin lymphoma as AIDS-defining cancers in 1987. Immune suppression rather than HIV itself is implicated in the pathogenesis of this malignancy, with a clear correlation between the degree of immune suppression and the risk of developing NHL. Additionally, other retroviruses, such as
852:
NHL consists of many different conditions that have little in common with each other. They are grouped by their aggressiveness. Less aggressive non-Hodgkin lymphomas are compatible with a long survival while more aggressive non-Hodgkin lymphomas can be rapidly fatal without treatment. Without further
767:
It is unclear if including aerobic physical exercise, in addition to the standard treatment for adult patients with haematological malignancies, is effective at reducing anxiety and serious adverse effects. Aerobic physical exercises may result in little to no difference in the mortality, in the
758:
may be necessary for those who receive chemotherapy or undergo a stem cell transplantation due to the higher risk for bleeding. When comparing therapeutic/non-prophylactic platelet transfusions to prophylactic platelet transfusions there is little to no difference in the mortality secondary to
820:
Age adjusted data from 2012 to 2016 shows about 19.6 cases of NHL per 100,000 adults per year, 5.6 deaths per 100,000 adults per year, and around 694,704 people living with non-Hodgkin lymphoma. About 2.2 percent of men and women will be diagnosed with NHL at some point during their lifetime.
664:
Familial lymphoid cancer is rare. The familial risk of lymphoma is elevated for multiple lymphoma subtypes, suggesting a shared genetic cause. However, a family history of a specific subtype is most strongly associated with risk for that subtype, indicating that these genetic factors are
2161:
Estcourt L, Stanworth S, Doree C, Hopewell S, Murphy MF, Tinmouth A, Heddle N, et al. (Cochrane
Haematological Malignancies Group) (May 2012). "Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell
1351:
811:
On average, according to data for the 2014–2016 period, around 13,900 people are diagnosed with NHL yearly. It is the sixth most common cancer in the UK, and is the eleventh most common cause of cancer death accounting for around 4,900 deaths per year.
512:
697:, leading to an increased rate of co-infection. The natural history of HIV infection has greatly changed over time. As a consequence, rates of non-Hodgkin lymphoma (NHL) in people infected with HIV has significantly declined in recent years.
2633:
2614:
2195:"Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation"
401:
In 2015, about 4.3 million people had non-Hodgkin lymphoma, and 231,400 (5.4%) died. In the United States, 2.1% of people are affected at some point in their life. The most common age of diagnosis is between 65 and 75 years old. The
1315:
Somigliana E, Vigano' P, Parazzini F, Stoppelli S, Giambattista E, Vercellini P (May 2006). "Association between endometriosis and cancer: a comprehensive review and a critical analysis of clinical and epidemiological evidence".
860:
Nevertheless, the
Working Formulation and the NHL category continue to be used by many. To this day, lymphoma statistics are compiled as Hodgkin's versus non-Hodgkin lymphomas by major cancer agencies, including the US
3672:
836:
While consensus was rapidly reached on the classification of
Hodgkin lymphoma, there remained a large group of very different diseases requiring further classification. The Rappaport classification, proposed by
1206:
3416:
1078:"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015"
803:
In Canada NHL is the fifth most common cancer in males and sixth most common cancer in females. The lifetime probability of developing a lymphoid cancer is 1 in 44 for males, and 1 in 51 for females.
1027:"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015"
2111:"Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition"
1379:
Maeda E, Akahane M, Kiryu S, Kato N, Yoshikawa T, Hayashi N, Aoki S, Minami M, Uozaki H, Fukayama M, Ohtomo K (2009). "Spectrum of
Epstein-Barr virus-related diseases: A pictorial review".
2970:
1926:"Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Council of State and Territorial Epidemiologists; AIDS Program, Center for Infectious Diseases"
2468:
3087:
2652:
3677:
3486:
1466:
Pinzone MR, Fiorica F, Di Rosa M, Malaguarnera G, Malaguarnera L, Cacopardo B, Zanghì G, Nunnari G (October 2012). "Non-AIDS-defining cancers among HIV-infected people".
343:
classifies lymphomas into five major groups, including one for
Hodgkin lymphoma. Within the four groups for NHL are over 60 specific types of lymphoma. Diagnosis is by
3700:
1198:
3052:
3746:
3442:
2781:
2109:
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J, et al. (Cochrane
Haematological Malignancies Group) (January 2019).
2340:"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010"
933:
3132:
293:, chest pain, or itchiness. Some forms are slow-growing while others are fast-growing. Unlike Hodgkin lymphoma, which spreads contiguously, NHL is largely a
3645:
874:
3684:
3230:
2975:
1176:
686:
3109:
740:, an antibody-drug conjugate, was included as a category 1 preferred regimen for first-line DLBCL by the National Comprehensive Cancer Network in 2023.
2438:
866:
2088:
489:
The many different forms of lymphoma probably have different causes. These possible causes and associations with at least some forms of NHL include:
3210:
3008:
3634:
3308:
2862:
379:
209:
2193:
Estcourt LJ, Stanworth SJ, Doree C, Hopewell S, Trivella M, Murphy MF, et al. (Cochrane
Haematological Malignancies Group) (November 2015).
768:
quality of life and in the physical functioning. These exercises may result in a slight reduction in depression and most likely reduce fatigue.
3481:
1495:"Current Status of the Epidemiologic Evidence Linking Polychlorinated Biphenyls and Non-Hodgkin Lymphoma, and the Role of Immune Dysregulation"
2296:
1791:"Soft Tissue Anaplastic Large T-Cell Lymphoma Associated with a Metallic Orthopedic Implant: Case Report and Review of the Current Literature"
3300:
2851:
2590:
2422:
1644:
1239:
1007:
1837:
3629:
2247:
Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N, et al. (Cochrane
Haematological Malignancies Group) (January 2019).
2476:
841:
in 1956 and 1966, became the first widely accepted classification of lymphomas other than
Hodgkin. Following its publication in 1982, the
776:
Prognosis depends on the subtype, the staging, a person's age, and other factors. Across all subtypes, 5-year survival for NHL is 71-74%.
1245:
3585:
3205:
3003:
2887:
2660:
3476:
2338:
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al. (15 December 2012).
2774:
1673:
845:
became the standard classification for this group of diseases. It introduced the term non-Hodgkin lymphoma or NHL and defined three
504:
2310:
336:
3437:
362:
Treatment depends on whether the lymphoma is slow- or fast-growing and if it is in one area or many areas. Treatments may include
1593:
Lauby-Secretan B, Loomis D, Grosse Y, El
Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K (2013).
974:
615:
2586:
3667:
3659:
3518:
3396:
3335:
3321:
3215:
3156:
2993:
2919:
1948:
670:
652:
558:
2000:
828:
lists non-Hodgkin lymphoma as one of the most common cancers in the United States, accounting for about 4% of all cancers.
3741:
3715:
3625:
3575:
3471:
3200:
2984:
1679:
1542:
Zani C, Toninelli G, Filisetti B, Donato F (2013). "Polychlorinated biphenyls and cancer: an epidemiological assessment".
666:
641:
566:
508:
321:
149:
3607:
3513:
3496:
3304:
2858:
2767:
634:
481:
Other tests and procedures may be done depending on the signs and symptoms seen and where the cancer forms in the body.
164:
3548:
3421:
3127:
787:
Rates of non-Hodgkin lymphoma increase steadily with age. Up to 45 years NHL is more common among males than females.
518:
925:
3463:
2066:
562:
414:
The signs and symptoms of non-Hodgkin lymphoma vary depending upon its location within the body. Symptoms include
3351:
3192:
3114:
2742:
2044:
862:
749:
581:
544:
340:
1424:"Hepatitis C-associated B-cell non-Hodgkin lymphomas. Epidemiology, molecular signature and clinical management"
733:, which is a regimen of four drugs (cyclophosphamide, doxorubicin, vincristine, and prednisone) plus rituximab.
3553:
3381:
2671:
2549:
1168:
266:
3019:
2324:
2022:
2581:
870:
825:
403:
229:
3570:
3121:
2446:
496:
3447:
3426:
3340:
1838:"Primary Anaplastic Large Cell Lymphoma of the Breast Occurring in Patients with Silicone Breast Implants"
1127:"B–NHL Cases in a Tertiary Pediatric Hematology—Oncology Department: A 20-Year Retrospective Cohort Study"
1750:
Stein ME, Lewis DC, Gershuny AR, Quigley MM, Zaidan J, Danieli NS, Whelan J, Subramanian R (April 2003).
3579:
3169:
3063:
522:
52:
3142:
2965:
2089:"With hard-fought Polivy approval, Roche looks to shake up decades of established practice in lymphoma"
500:
3376:
2988:
2899:
2498:
1551:
755:
714:
630:
611:
64:
3176:
2960:
2930:
2637:
842:
737:
622:
529:
1664:. In Kufe DW, Pollock RE, Weichselbaum RR, Bast RC Jr, Gansler TS, Holland JF, Frei E III (eds.).
1594:
3640:
2387:
1575:
1404:
344:
317:
179:
145:
96:
1365:
3751:
3720:
3390:
3371:
3360:
3150:
3040:
2955:
2711:
2682:
2418:
2379:
2278:
2224:
2175:
2140:
1982:
1940:
1906:
1857:
1818:
1810:
1790:
1771:
1763:
1732:
1714:
1669:
1640:
1614:
1567:
1524:
1475:
1445:
1396:
1333:
1297:
1235:
1229:
1107:
1056:
1003:
600:
593:
585:
554:
548:
367:
348:
197:
183:
174:
80:
3490:
3269:
3137:
3036:
2759:
2410:
2369:
2359:
2351:
2268:
2260:
2214:
2206:
2167:
2130:
2122:
1974:
1896:
1888:
1849:
1802:
1722:
1706:
1606:
1559:
1514:
1506:
1435:
1388:
1325:
1289:
1148:
1138:
1097:
1089:
1046:
1038:
846:
674:
534:
383:
375:
313:
309:
294:
274:
217:
205:
141:
394:
may be used. Radiation and some chemotherapy, however, increase the risk of other cancers,
3263:
3258:
3067:
2951:
2817:
2812:
2577:
2405:
Patte C, Bleyer A, Cairo MS (2007). "Non-Hodgkin Lymphoma". In Bleyer WA, Barr RD (eds.).
838:
415:
352:
278:
101:
1789:
Palraj B, Paturi A, Stone RG, Alvarez H, Sebenik M, Perez MT, Bush LM (1 November 2010).
1695:"A Highly Curable Lymphoma Occurs Preferentially in the Proximal Tibia of Young Patients"
1693:
Subik MK, Herr M, Hutchison RE, Kelly J, Tyler W, Merzianu M, Burack WR (November 2014).
2736:
2374:
1555:
1153:
1126:
3710:
2273:
2248:
2219:
2194:
2135:
2110:
1901:
1876:
1727:
1694:
1519:
1494:
1102:
1077:
1051:
1026:
626:
391:
356:
68:
2355:
1610:
1093:
1042:
3735:
3617:
3316:
3225:
3181:
2998:
2872:
2529:
National Cancer Institute: Surveillance, Epidemiology, and End Results (SEER) Program
2364:
2297:"Survival Rates and Factors That Affect Prognosis (Outlook) for Non-Hodgkin Lymphoma"
853:
narrowing, the label is of limited usefulness for people or doctors. The subtypes of
718:
430:
395:
371:
201:
17:
2646:
2642:
1853:
3220:
2882:
2722:
2391:
2264:
2210:
2171:
2126:
1579:
1408:
795:
Around 6600 people are diagnosed with non-Hodgkin lymphoma in Australia each year.
710:
706:
604:
423:
363:
286:
193:
109:
2524:
1925:
1259:
966:
72:
2676:
1892:
1563:
1293:
2894:
2706:
2414:
1329:
645:
328:
156:
136:
113:
2725:
2249:"Aerobic physical exercise for adult patients with haematological malignancies"
1806:
1661:
1440:
1423:
1125:
Kyriakidis I, Pelagiadis I, Stratigaki M, Katzilakis N, Stiakaki E (May 2024).
467:
If cancer is found, the following tests may be done to study the cancer cells:
2790:
2731:
2687:
1710:
1392:
387:
305:
85:
60:
1986:
1861:
1814:
1767:
1752:"Trauma as an etiologic factor of primary bone lymphoma: a report of 4 cases"
1718:
2717:
2627:
2623:
1836:
Popplewell L, Chang K, Olevsky O, Nademanee A, Forman S (16 November 2004).
1751:
290:
224:
117:
2383:
2282:
2228:
2179:
2144:
1910:
1822:
1775:
1736:
1618:
1595:"Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls"
1571:
1528:
1479:
1449:
1400:
1337:
1301:
1111:
1060:
1944:
784:
Globally, as of 2010, there were 210,000 deaths, up from 143,000 in 1990.
3705:
3533:
3244:
2807:
2794:
1965:
Lee B, Bower M, Newsom-Davis T, Nelson M (2010). "HIV-related lymphoma".
1169:"Adult Non-Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version"
1143:
854:
270:
89:
2606:
1510:
332:
213:
160:
121:
1978:
3253:
2747:
2618:
730:
729:
The most common chemotherapy used for B-cell non-Hodgkin lymphoma is
589:
301:
2339:
3076:
2941:
2925:
748:
If participants receive stem-cell transplants, they can develop a
540:
419:
282:
105:
3539:
3433:
3412:
3330:
3072:
3047:
3027:
3023:
2910:
2828:
2823:
2665:
690:
2763:
1877:"Familial predisposition and genetic risk factors for lymphoma"
3279:
3274:
3164:
1002:. World Health Organization. 2014. pp. Chapter 2.4, 2.6.
694:
572:
1422:
Peveling-Oberhag J, Arcaini L, Hansmann ML, Zeuzem S (2013).
926:"Adult Non-Hodgkin Lymphoma Treatment (PDQ®)–Patient Version"
651:
Implants, made from hard metals or silicone, associated with
3417:
Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
2407:
Cancer in Adolescents and Young Adults (Pediatric Oncology)
386:. If the blood becomes overly thick due to high numbers of
289:, weight loss, and tiredness. Other symptoms may include
1468:
European Review for Medical and Pharmacological Sciences
433:
has been described, these associations are tentative.
429:
While an association between non-Hodgkin lymphoma and
1493:
Kramer S, Hikel SM, Adams K, Hinds D, Moon K (2012).
1461:
1459:
2596:
3693:
3658:
3616:
3598:
3562:
3532:
3505:
3460:
3405:
3359:
3350:
3290:
3252:
3243:
3191:
3101:
3062:
3018:
2940:
2909:
2871:
2850:
2839:
2806:
2697:
2600:
693:, may be spread by the same mechanisms that spread
244:
236:
223:
189:
173:
135:
127:
95:
79:
42:
37:
3487:Peripheral T-cell lymphoma not otherwise specified
3309:Precursor T acute lymphoblastic leukemia/lymphoma
2863:Precursor B acute lymphoblastic leukemia/lymphoma
2311:"Prognosis and survival for non-Hodgkin lymphoma"
1924:Centers for Disease Control (CDC) (August 1987).
398:, or nerve problems over the subsequent decades.
3053:Nodular lymphocyte predominant Hodgkin lymphoma
640:Bone trauma and microfractures associated with
920:
918:
916:
914:
912:
910:
3443:Secondary cutaneous CD30+ large-cell lymphoma
2775:
1630:
1628:
967:"SEER Stat Fact Sheets: Non-Hodgkin Lymphoma"
908:
906:
904:
902:
900:
898:
896:
894:
892:
890:
460:PET scan (positron emission tomography scan).
8:
3133:Post-transplant lymphoproliferative disorder
3088:immunoproliferative immunoglobulin disorders
1668:(5th ed.). Hamilton, Ont: B.C. Decker.
1021:
1019:
994:
992:
3646:Diffuse infiltrative lymphocytosis syndrome
2253:The Cochrane Database of Systematic Reviews
2199:The Cochrane Database of Systematic Reviews
2164:The Cochrane Database of Systematic Reviews
2115:The Cochrane Database of Systematic Reviews
1072:
1070:
3685:Jessner lymphocytic infiltrate of the skin
3356:
3287:
3249:
3231:Primary cutaneous follicle center lymphoma
2976:Primary cutaneous follicle center lymphoma
2847:
2836:
2803:
2782:
2768:
2760:
2597:
961:
959:
957:
955:
953:
951:
705:The traditional treatment of NHL includes
687:Centers for Disease Control and Prevention
51:
34:
2550:"Key Statistics for Non-Hodgkin Lymphoma"
2525:"Cancer Stat Facts: Non-Hodgkin Lymphoma"
2373:
2363:
2272:
2218:
2134:
2003:. Cancer Council Australia. 22 March 2019
1900:
1726:
1518:
1439:
1234:. Elsevier Health Sciences. p. 878.
1199:"Different types of non Hodgkin lymphoma"
1152:
1142:
1101:
1050:
3211:Primary cutaneous marginal zone lymphoma
3009:Primary cutaneous marginal zone lymphoma
2045:"Immunotherapy for Non-Hodgkin Lymphoma"
1660:Arnold S Freedman, Lee M Nadler (2000).
1282:Gynécologie, Obstétrique & Fertilité
441:Tests for non-Hodgkin lymphoma include;
3673:with bandlike and perivascular patterns
3635:Autoimmune lymphoproliferative syndrome
1682:from the original on 10 September 2017.
1248:from the original on 10 September 2017.
886:
717:. There have also been developments in
3482:Enteropathy-associated T-cell lymphoma
2325:"Non-Hodgkin Lymphoma Treatment - NCI"
2067:"Treating B-Cell Non-Hodgkin Lymphoma"
1875:Cerhan JR, Slager SL (November 2015).
1662:"Chapter 130: Non–Hodgkin's Lymphomas"
1352:"Non-Hodgkin Lymphoma Treatment - NCI"
677:, most of which are subtype specific.
3747:Hepatitis C virus-associated diseases
2591:American Society of Clinical Oncology
2242:
2240:
2238:
2156:
2154:
2104:
2102:
2100:
2098:
1795:The Journal of Foot and Ankle Surgery
7:
3630:X-linked lymphoproliferative disease
1088:(10053): 1459–1544. 8 October 2016.
1037:(10053): 1545–1602. 8 October 2016.
3586:Large granular lymphocytic leukemia
3206:Intravascular large B-cell lymphoma
1209:from the original on 14 August 2016
1179:from the original on 12 August 2016
936:from the original on 16 August 2016
1366:"Non-Hodgkin lymphoma - Diagnosis"
463:Bone marrow aspiration and biopsy.
240:4.3 million (affected during 2015)
67:, a type of non-Hodgkin lymphoma.
25:
2499:"Non-hodgkin lymphoma statistics"
1954:from the original on 9 June 2017.
1639:(7th ed.). Wiley-Blackwell.
1499:Environmental Health Perspectives
618:, ataxia–telangiectasia syndrome.
505:follicular dendritic cell sarcoma
451:Hepatitis B and hepatitis C test.
2023:"Non-Hodgkin Lymphoma Treatment"
977:from the original on 6 July 2014
669:have successfully identified 67
3438:CD30+ cutaneous T-cell lymphoma
2439:"What is non-Hodgkin lymphoma?"
2069:. American Cancer Society. 2019
2047:. American Cancer Society. 2019
2025:. American Cancer Society. 2019
1854:10.1182/blood.V104.11.4563.4563
1635:Tobias J, Hochhauser D (2015).
671:single-nucleotide polymorphisms
667:Genome-wide association studies
3668:Cutaneous lymphoid hyperplasia
3660:Cutaneous lymphoid hyperplasia
3519:Adult T-cell leukemia/lymphoma
3397:Adult T-cell leukemia/lymphoma
3336:Anaplastic large-cell lymphoma
3216:Primary cutaneous immunocytoma
3157:Splenic marginal zone lymphoma
2265:10.1002/14651858.CD009075.pub3
2211:10.1002/14651858.CD010983.pub2
2172:10.1002/14651858.CD004269.pub3
2127:10.1002/14651858.CD009768.pub2
1228:Bope ET, Kellerman RD (2015).
721:used in the treatment of NHL.
653:anaplastic large cell lymphoma
559:splenic marginal zone lymphoma
549:multicentric Castleman disease
1:
3716:Lymphoproliferative disorders
3626:Lymphoproliferative disorders
3576:Extranodal NK-T-cell lymphoma
3448:Lymphomatoid papulosis type A
3427:Lymphomatoid papulosis type B
3341:Lymphomatoid papulosis type A
3201:Diffuse large B-cell lymphoma
2356:10.1016/S0140-6736(12)61728-0
1611:10.1016/s1470-2045(13)70104-9
1381:Japanese Journal of Radiology
1280:Audebert A (April 2005). "".
1094:10.1016/s0140-6736(16)31012-1
1043:10.1016/S0140-6736(16)31678-6
642:diffuse large B-cell lymphoma
567:diffuse large B-cell lymphoma
513:diffuse large B-cell lymphoma
509:extranodal NK-T-cell lymphoma
406:in the United States is 71%.
27:Type of cancer of lymph nodes
3608:Acute biphenotypic leukaemia
3497:Subcutaneous T-cell lymphoma
2469:"Canadian Cancer Statistics"
1893:10.1182/blood-2015-04-537498
1666:Holland-Frei Cancer Medicine
1564:10.1080/10590501.2013.782174
1294:10.1016/j.gyobfe.2005.03.010
635:systemic lupus erythematosus
345:examination of a bone marrow
337:Epstein–Barr virus infection
3549:Aggressive NK-cell leukemia
3422:Pleomorphic T-cell lymphoma
3128:Lymphomatoid granulomatosis
2415:10.1007/978-3-540-68152-6_9
1330:10.1016/j.ygyno.2005.11.033
1231:Conn's Current Therapy 2016
519:Human T-cell leukemia virus
445:Complete blood count (CBC).
269:that includes all types of
3768:
1807:10.1053/j.jfas.2010.08.009
1441:10.1016/j.jhep.2013.03.018
621:Autoimmune diseases, like
563:lymphoplasmacytic lymphoma
2802:
2409:. Springer. p. 129.
1711:10.1038/modpathol.2014.51
1637:Cancer and its Management
1544:J. Environ. Sci. Health C
1393:10.1007/s11604-008-0291-2
863:National Cancer Institute
750:graft-versus-host disease
599:Medical treatments, like
582:polychlorinated biphenyls
545:primary effusion lymphoma
380:stem-cell transplantation
341:World Health Organization
210:stem cell transplantation
59:
50:
3701:Hematological malignancy
3554:Blastic NK cell lymphoma
3382:Granulomatous slack skin
3138:Classic Hodgkin lymphoma
3037:Classic Hodgkin lymphoma
1000:World Cancer Report 2014
616:Chédiak–Higashi syndrome
448:Blood chemistry studies.
2582:American Cancer Society
871:Canadian Cancer Society
826:American Cancer Society
744:Treatment complications
610:Genetic diseases, like
404:five-year survival rate
312:. Risk factors include
300:Lymphomas are types of
230:Five-year survival rate
2445:. 2023. Archived from
2001:"Non-Hodgkin lymphoma"
1260:"Non-Hodgkin Lymphoma"
263:non-Hodgkin's lymphoma
3580:Angiocentric lymphoma
3170:AIDS-related lymphoma
2994:Splenic marginal zone
2587:Non-Hodgkins Lymphoma
2365:10536/DRO/DU:30050819
1428:Journal of Hepatology
756:Platelet transfusions
715:stem-cell transplants
580:Some chemicals, like
523:adult T-cell lymphoma
474:Cytogenetic analysis.
471:Immunohistochemistry.
355:is done to help with
18:Lymphoma, non-hodgkin
3742:Non-Hodgkin lymphoma
3678:with nodular pattern
3377:Pagetoid reticulosis
2989:marginal zone B-cell
2748:Non-Hodgkin lymphoma
2737:Non-Hodgkin lymphoma
2578:Non-Hodgkin Lymphoma
2443:www.leukaemia.org.au
1318:Gynecologic Oncology
1144:10.3390/life14050633
631:rheumatoid arthritis
612:Klinefelter syndrome
416:enlarged lymph nodes
314:poor immune function
279:enlarged lymph nodes
255:Non-Hodgkin lymphoma
142:Poor immune function
102:Enlarged lymph nodes
65:mantle cell lymphoma
38:Non-Hodgkin lymphoma
3177:Helicobacter pylori
3004:Nodal marginal zone
2931:Hairy cell leukemia
2797:and related disease
2327:. 24 November 2023.
1556:2013JESHC..31...99Z
1511:10.1289/ehp.1104652
1354:. 24 November 2023.
843:Working Formulation
738:polatuzumab vedotin
530:Helicobacter pylori
493:Infectious agents:
457:CT scan (CAT scan).
323:Helicobacter pylori
318:autoimmune diseases
277:. Symptoms include
151:Helicobacter pylori
146:autoimmune diseases
46:Non-Hodgkin disease
3721:Lymphoid leukemias
3641:Leukemoid reaction
3477:Angioimmunoblastic
3143:Burkitt's lymphoma
2698:External resources
2503:Cancer Research UK
2479:on 25 January 2018
2350:(9859): 2095–128.
2162:transplantation".
1368:. 23 October 2017.
1203:Cancer Research UK
857:are listed there.
665:subtype-specific.
660:Familial component
594:phenoxy herbicides
557:: associated with
543:: associated with
533:: associated with
521:: associated with
501:Burkitt's lymphoma
499:: associated with
497:Epstein–Barr virus
477:Immunophenotyping.
410:Signs and symptoms
304:that develop from
166:Epstein-Barr virus
3729:
3728:
3654:
3653:
3594:
3593:
3528:
3527:
3456:
3455:
3372:Mycosis fungoides
3239:
3238:
3097:
3096:
3041:Nodular sclerosis
2956:follicular B cell
2757:
2756:
2589:from Cancer.net (
2424:978-3-540-40842-0
1979:10.2217/hiv.10.54
1756:Journal of B.U.ON
1705:(11): 1430–1437.
1646:978-1-118-46871-5
1241:978-0-323-35535-3
1009:978-92-832-0429-9
932:. 3 August 2016.
601:radiation therapy
586:diphenylhydantoin
555:Hepatitis C virus
349:lymph node biopsy
275:Hodgkin lymphomas
261:), also known as
252:
251:
184:lymph node biopsy
175:Diagnostic method
32:Medical condition
16:(Redirected from
3759:
3491:Lennert lymphoma
3357:
3288:
3250:
3115:Primary effusion
2848:
2837:
2804:
2784:
2777:
2770:
2761:
2598:
2565:
2564:
2562:
2560:
2546:
2540:
2539:
2537:
2535:
2521:
2515:
2514:
2512:
2510:
2495:
2489:
2488:
2486:
2484:
2475:. Archived from
2465:
2459:
2458:
2456:
2454:
2435:
2429:
2428:
2402:
2396:
2395:
2377:
2367:
2335:
2329:
2328:
2321:
2315:
2314:
2307:
2301:
2300:
2293:
2287:
2286:
2276:
2244:
2233:
2232:
2222:
2205:(11): CD010983.
2190:
2184:
2183:
2158:
2149:
2148:
2138:
2106:
2093:
2092:
2091:. Fierce Pharma.
2085:
2079:
2078:
2076:
2074:
2063:
2057:
2056:
2054:
2052:
2041:
2035:
2034:
2032:
2030:
2019:
2013:
2012:
2010:
2008:
1997:
1991:
1990:
1962:
1956:
1955:
1953:
1933:MMWR Supplements
1930:
1921:
1915:
1914:
1904:
1872:
1866:
1865:
1833:
1827:
1826:
1786:
1780:
1779:
1747:
1741:
1740:
1730:
1699:Modern Pathology
1690:
1684:
1683:
1657:
1651:
1650:
1632:
1623:
1622:
1590:
1584:
1583:
1539:
1533:
1532:
1522:
1490:
1484:
1483:
1463:
1454:
1453:
1443:
1419:
1413:
1412:
1376:
1370:
1369:
1362:
1356:
1355:
1348:
1342:
1341:
1312:
1306:
1305:
1277:
1271:
1270:
1268:
1266:
1256:
1250:
1249:
1225:
1219:
1218:
1216:
1214:
1195:
1189:
1188:
1186:
1184:
1165:
1159:
1158:
1156:
1146:
1122:
1116:
1115:
1105:
1074:
1065:
1064:
1054:
1023:
1014:
1013:
996:
987:
986:
984:
982:
963:
946:
945:
943:
941:
922:
623:Sjögren syndrome
535:gastric lymphoma
384:watchful waiting
376:targeted therapy
310:white blood cell
295:systemic illness
265:, is a group of
218:watchful waiting
206:targeted therapy
55:
35:
21:
3767:
3766:
3762:
3761:
3760:
3758:
3757:
3756:
3732:
3731:
3730:
3725:
3689:
3650:
3612:
3600:
3590:
3558:
3537:
3524:
3501:
3462:
3452:
3401:
3346:
3294:
3292:
3267:
3262:
3256:
3235:
3187:
3093:
3070:
3058:
3014:
2952:germinal center
2936:
2905:
2867:
2843:
2841:
2821:
2816:
2810:
2798:
2788:
2758:
2753:
2752:
2693:
2692:
2609:
2574:
2569:
2568:
2558:
2556:
2548:
2547:
2543:
2533:
2531:
2523:
2522:
2518:
2508:
2506:
2497:
2496:
2492:
2482:
2480:
2467:
2466:
2462:
2452:
2450:
2449:on 16 July 2023
2437:
2436:
2432:
2425:
2404:
2403:
2399:
2337:
2336:
2332:
2323:
2322:
2318:
2313:. October 2023.
2309:
2308:
2304:
2295:
2294:
2290:
2259:(1): CD009075.
2246:
2245:
2236:
2192:
2191:
2187:
2166:(5): CD004269.
2160:
2159:
2152:
2121:(1): CD009768.
2108:
2107:
2096:
2087:
2086:
2082:
2072:
2070:
2065:
2064:
2060:
2050:
2048:
2043:
2042:
2038:
2028:
2026:
2021:
2020:
2016:
2006:
2004:
1999:
1998:
1994:
1964:
1963:
1959:
1951:
1928:
1923:
1922:
1918:
1887:(20): 2265–73.
1874:
1873:
1869:
1835:
1834:
1830:
1788:
1787:
1783:
1749:
1748:
1744:
1692:
1691:
1687:
1676:
1659:
1658:
1654:
1647:
1634:
1633:
1626:
1599:Lancet Oncology
1592:
1591:
1587:
1541:
1540:
1536:
1492:
1491:
1487:
1474:(10): 1377–88.
1465:
1464:
1457:
1421:
1420:
1416:
1378:
1377:
1373:
1364:
1363:
1359:
1350:
1349:
1345:
1314:
1313:
1309:
1279:
1278:
1274:
1264:
1262:
1258:
1257:
1253:
1242:
1227:
1226:
1222:
1212:
1210:
1197:
1196:
1192:
1182:
1180:
1175:. 1 June 2016.
1167:
1166:
1162:
1124:
1123:
1119:
1076:
1075:
1068:
1025:
1024:
1017:
1010:
998:
997:
990:
980:
978:
965:
964:
949:
939:
937:
924:
923:
888:
883:
839:Henry Rappaport
834:
818:
809:
801:
793:
782:
774:
765:
746:
727:
703:
683:
662:
644:originating in
487:
439:
412:
353:Medical imaging
131:65–75 years old
33:
28:
23:
22:
15:
12:
11:
5:
3765:
3763:
3755:
3754:
3749:
3744:
3734:
3733:
3727:
3726:
3724:
3723:
3718:
3713:
3711:Leukemia cutis
3708:
3703:
3697:
3695:
3691:
3690:
3688:
3687:
3682:
3681:
3680:
3675:
3664:
3662:
3656:
3655:
3652:
3651:
3649:
3648:
3643:
3638:
3632:
3622:
3620:
3614:
3613:
3611:
3610:
3604:
3602:
3596:
3595:
3592:
3591:
3589:
3588:
3583:
3566:
3564:
3560:
3559:
3557:
3556:
3551:
3545:
3543:
3530:
3529:
3526:
3525:
3523:
3522:
3509:
3507:
3503:
3502:
3500:
3499:
3494:
3484:
3479:
3474:
3468:
3466:
3458:
3457:
3454:
3453:
3451:
3450:
3445:
3440:
3430:
3429:
3424:
3419:
3409:
3407:
3403:
3402:
3400:
3399:
3391:Sézary disease
3385:
3384:
3379:
3374:
3365:
3363:
3354:
3348:
3347:
3345:
3344:
3338:
3326:
3325:
3322:Prolymphocytic
3312:
3298:
3296:
3285:
3284:
3283:
3277:
3247:
3241:
3240:
3237:
3236:
3234:
3233:
3228:
3223:
3218:
3213:
3208:
3203:
3197:
3195:
3189:
3188:
3186:
3185:
3173:
3161:
3160:
3159:
3147:
3146:
3145:
3140:
3135:
3130:
3118:
3105:
3103:
3099:
3098:
3095:
3094:
3092:
3091:
3082:
3080:
3060:
3059:
3057:
3056:
3044:
3033:
3031:
3016:
3015:
3013:
3012:
3006:
3001:
2996:
2980:
2979:
2973:
2968:
2963:
2947:
2945:
2938:
2937:
2935:
2934:
2922:
2920:Prolymphocytic
2916:
2914:
2907:
2906:
2904:
2903:
2891:
2878:
2876:
2869:
2868:
2866:
2856:
2854:
2845:
2834:
2833:
2832:
2800:
2799:
2789:
2787:
2786:
2779:
2772:
2764:
2755:
2754:
2751:
2750:
2739:
2728:
2714:
2702:
2701:
2699:
2695:
2694:
2691:
2690:
2679:
2668:
2657:
2649:
2630:
2610:
2605:
2604:
2602:
2601:Classification
2595:
2594:
2584:
2573:
2572:External links
2570:
2567:
2566:
2554:www.cancer.org
2541:
2516:
2490:
2460:
2430:
2423:
2397:
2330:
2316:
2302:
2288:
2234:
2185:
2150:
2094:
2080:
2058:
2036:
2014:
1992:
1973:(6): 649–659.
1957:
1916:
1867:
1828:
1801:(6): 561–564.
1781:
1762:(2): 163–166.
1742:
1685:
1674:
1652:
1645:
1624:
1605:(4): 287–288.
1585:
1534:
1505:(8): 1067–75.
1485:
1455:
1434:(1): 169–177.
1414:
1371:
1357:
1343:
1307:
1272:
1251:
1240:
1220:
1190:
1160:
1117:
1066:
1015:
1008:
988:
973:. April 2016.
947:
885:
884:
882:
879:
833:
830:
817:
814:
808:
807:United Kingdom
805:
800:
797:
792:
789:
781:
778:
773:
770:
764:
761:
745:
742:
726:
723:
702:
699:
682:
679:
661:
658:
657:
656:
649:
638:
627:celiac disease
619:
608:
597:
578:
577:
576:
570:
552:
538:
526:
516:
486:
483:
479:
478:
475:
472:
465:
464:
461:
458:
455:
452:
449:
446:
438:
435:
411:
408:
392:plasmapheresis
382:, surgery, or
357:cancer staging
250:
249:
248:231,400 (2015)
246:
242:
241:
238:
234:
233:
227:
221:
220:
191:
187:
186:
177:
171:
170:
139:
133:
132:
129:
125:
124:
99:
93:
92:
83:
77:
76:
69:Terminal ileum
57:
56:
48:
47:
44:
40:
39:
31:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3764:
3753:
3750:
3748:
3745:
3743:
3740:
3739:
3737:
3722:
3719:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3698:
3696:
3692:
3686:
3683:
3679:
3676:
3674:
3671:
3670:
3669:
3666:
3665:
3663:
3661:
3657:
3647:
3644:
3642:
3639:
3636:
3633:
3631:
3627:
3624:
3623:
3621:
3619:
3618:Lymphocytosis
3615:
3609:
3606:
3605:
3603:
3597:
3587:
3584:
3581:
3577:
3573:
3572:
3568:
3567:
3565:
3561:
3555:
3552:
3550:
3547:
3546:
3544:
3541:
3535:
3531:
3520:
3516:
3515:
3511:
3510:
3508:
3504:
3498:
3495:
3492:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3472:Hepatosplenic
3470:
3469:
3467:
3465:
3459:
3449:
3446:
3444:
3441:
3439:
3435:
3432:
3431:
3428:
3425:
3423:
3420:
3418:
3414:
3411:
3410:
3408:
3404:
3398:
3395:
3394:
3393:
3392:
3389:
3383:
3380:
3378:
3375:
3373:
3370:
3367:
3366:
3364:
3362:
3358:
3355:
3353:
3349:
3342:
3339:
3337:
3333:
3332:
3328:
3327:
3323:
3319:
3318:
3317:prolymphocyte
3314:
3313:
3310:
3306:
3302:
3299:
3297:
3289:
3286:
3281:
3278:
3276:
3273:
3272:
3271:
3265:
3260:
3255:
3251:
3248:
3246:
3242:
3232:
3229:
3227:
3226:Plasmacytosis
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3198:
3196:
3194:
3190:
3183:
3182:MALT lymphoma
3179:
3178:
3174:
3171:
3167:
3166:
3162:
3158:
3155:
3154:
3153:
3152:
3148:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3125:
3124:
3123:
3119:
3116:
3112:
3111:
3107:
3106:
3104:
3100:
3090:
3089:
3084:
3083:
3081:
3078:
3074:
3069:
3065:
3061:
3054:
3050:
3049:
3045:
3042:
3038:
3035:
3034:
3032:
3029:
3025:
3021:
3017:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2991:
2990:
2986:
2985:marginal zone
2982:
2981:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2958:
2957:
2953:
2949:
2948:
2946:
2943:
2939:
2932:
2928:
2927:
2923:
2921:
2918:
2917:
2915:
2912:
2908:
2901:
2897:
2896:
2892:
2889:
2885:
2884:
2880:
2879:
2877:
2874:
2870:
2864:
2860:
2857:
2855:
2853:
2849:
2846:
2838:
2835:
2830:
2827:
2826:
2825:
2819:
2814:
2809:
2805:
2801:
2796:
2792:
2785:
2780:
2778:
2773:
2771:
2766:
2765:
2762:
2749:
2745:
2744:
2740:
2738:
2734:
2733:
2729:
2727:
2724:
2720:
2719:
2715:
2713:
2709:
2708:
2704:
2703:
2700:
2696:
2689:
2685:
2684:
2680:
2678:
2674:
2673:
2669:
2667:
2663:
2662:
2658:
2655:
2654:
2650:
2648:
2644:
2640:
2639:
2635:
2631:
2629:
2625:
2621:
2620:
2616:
2612:
2611:
2608:
2603:
2599:
2592:
2588:
2585:
2583:
2579:
2576:
2575:
2571:
2555:
2551:
2545:
2542:
2530:
2526:
2520:
2517:
2505:. 14 May 2015
2504:
2500:
2494:
2491:
2478:
2474:
2473:www.cancer.ca
2470:
2464:
2461:
2448:
2444:
2440:
2434:
2431:
2426:
2420:
2416:
2412:
2408:
2401:
2398:
2393:
2389:
2385:
2381:
2376:
2371:
2366:
2361:
2357:
2353:
2349:
2345:
2341:
2334:
2331:
2326:
2320:
2317:
2312:
2306:
2303:
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707:chemotherapy
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165:
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137:Risk factors
110:night sweats
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2900:Mantle cell
2895:mantle zone
2707:MedlinePlus
1967:HIV Therapy
1387:(1): 4–19.
736:R-CHP with
646:bone marrow
329:hepatitis C
306:lymphocytes
180:Bone marrow
157:hepatitis C
128:Usual onset
114:weight loss
43:Other names
3736:Categories
3464:peripheral
2961:Follicular
2791:Leukaemias
2732:Patient UK
2683:DiseasesDB
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881:References
575:infection.
388:antibodies
86:Hematology
61:Micrograph
3599:Lymphoid+
3369:indolent:
3352:Cutaneous
3193:Cutaneous
2971:GCB DLBCL
2966:Burkitt's
2795:lymphomas
2718:eMedicine
2559:24 August
2534:24 August
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2073:23 August
2051:23 August
2029:23 August
2007:23 August
1987:1758-4310
1862:0006-4971
1815:1067-2516
1768:1107-0625
1719:0893-3952
1213:13 August
1183:13 August
981:13 August
940:13 August
791:Australia
772:Prognosis
701:Treatment
454:HIV test.
437:Diagnosis
368:radiation
325:infection
291:bone pain
271:lymphomas
237:Frequency
232:71% (USA)
225:Prognosis
198:radiation
190:Treatment
168:infection
153:infection
118:tiredness
81:Specialty
3752:Lymphoma
3706:leukemia
3264:leukemia
3259:lymphoma
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2726:ped/1343
2723:med/1363
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1207:Archived
1177:Archived
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1061:27733282
975:Archived
934:Archived
873:and the
855:lymphoma
681:HIV/AIDS
673:from 41
584:(PCBs),
97:Symptoms
90:oncology
3694:General
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832:History
333:obesity
273:except
214:surgery
161:obesity
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3514:HTLV-1
3406:Non-MF
3295:marker
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3077:CD138
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2653:ICD-O
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1405:S2CID
763:Other
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2672:MeSH
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2141:PMID
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2009:2019
1983:ISSN
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1131:Life
1108:PMID
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875:IARC
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691:HTLV
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675:loci
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