373:
350:
247:
272:
3039:
3069:
3054:
624:
379:
278:
40:
66:
1271:
family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional
2182:
Billiard J, Dennison JB, Briand J, Annan RS, Chai D, Colón M, Dodson CS, Gilbert SA, Greshock J, Jing J, Lu H, McSurdy-Freed JE, Orband-Miller LA, Mills GB, Quinn CJ, Schneck JL, Scott GF, Shaw AN, Waitt GM, Wooster RF, Duffy KJ (September 2013).
2281:
Maekawa M, Sudo K, Li SS, Kanno T (October 1991). "Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining".
2259:
Sudo K, Maekawa M, Shioya M, Ikeda K, Takahashi N, Isogai Y, Li SS, Kanno T, Machida K, Toriumi J (September 1992). "Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit".
2775:
Vilà MR, Nicolás A, Morote J, de I, Meseguer A (July 2000). "Increased glyceraldehyde-3-phosphate dehydrogenase expression in renal cell carcinoma identified by RNA-based, arbitrarily primed polymerase chain reaction".
1836:
1374:
1763:
1301:
1838:
1376:
2711:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
3038:
2893:
Sung JH, Shin SA, Park HK, Montelaro RC, Chong YH (October 2001). "Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells".
3068:
3053:
386:
285:
2856:
Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL (May 2001). "Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase".
2674:
Miyajima H, Takahashi Y, Suzuki M, Shimizu T, Kaneko E (July 1993). "Molecular characterization of gene expression in human lactate dehydrogenase-A deficiency".
2311:
Maekawa M, Sudo K, Li SS, Kanno T (November 1991). "Genotypic analysis of families with lactate dehydrogenase A (M) deficiency by selective DNA amplification".
2612:"Fast-type electrophoretic variant of lactate dehydrogenase M(A) and comparison with other missense mutations in lactate dehydrogenase M(A) and H(B) genes"
922:
208:
903:
1786:
1783:
1324:
1321:
1795:
1333:
2645:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1824:
1362:
2740:
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (November 1999).
3097:
3018:
1993:
1975:
1803:
1341:
63:
1767:
1305:
2758:
2741:
1814:
1352:
372:
1166:
1805:
1791:
1775:
1343:
1329:
1313:
1811:
1770:
1349:
1308:
1264:
1173:
2869:
1835:
1798:
1373:
1336:
349:
2060:
1826:
1825:
1809:
1802:
1799:
1364:
1363:
1347:
1340:
1337:
1833:
1832:
1830:
1788:
1766:
1371:
1370:
1368:
1326:
1304:
2789:
1962:
1941:
1787:
1769:
1325:
1307:
1779:
1778:
1317:
1316:
3102:
1837:
1785:
1375:
1323:
271:
246:
1958:
1937:
1792:
1774:
1330:
1312:
2815:"Direct role of plasma membrane-expressed gp120/41 in toxicity to human astrocytes induced by HIV-1-infected macrophages"
2135:"Metabolic Consequences of LDHA inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells"
1806:
1771:
1344:
1309:
188:
1834:
1801:
1797:
1790:
1372:
1339:
1335:
1328:
1812:
1804:
1768:
1350:
1342:
1306:
1817:
1355:
2350:"Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11"
1807:
1796:
1780:
1345:
1334:
1318:
385:
284:
1773:
1311:
3011:
1839:
1794:
1377:
1332:
378:
277:
1823:
1784:
1361:
1322:
1909:
1831:
1815:
1813:
1808:
1777:
1772:
1369:
1353:
1351:
1346:
1315:
1310:
971:
196:
1829:
1828:
1827:
1822:
1821:
1820:
1810:
1800:
1793:
1789:
1782:
1781:
1776:
1367:
1366:
1365:
1360:
1359:
1358:
1348:
1338:
1331:
1327:
1320:
1319:
1314:
1267:. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumors, and belongs to the
1914:
1819:
1818:
1816:
1357:
1356:
1354:
1244:
2565:
Glass RD, Doyle D (April 1972). "Genetic control of lactate dehydrogenase expression in mammalian tissues".
952:
948:
2532:"Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme"
2185:"Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells"
1268:
1240:
260:
3004:
2574:
2447:
2361:
2087:
175:
1145:
1120:
1116:
1112:
1108:
1078:
1053:
1049:
1045:
1041:
2918:
2881:
2844:
2801:
2699:
2598:
2336:
220:
2403:"Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency"
1149:
1124:
1082:
1057:
2932:"Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1"
2973:
2953:
2910:
2873:
2836:
2793:
2763:
2728:
2691:
2662:
2633:
2590:
2553:
2518:
2475:
2422:
2389:
2328:
2299:
2269:
2247:
2216:
2164:
2115:
2042:
168:
56:
2436:"Centrosomal proteins and lactate dehydrogenase possess a common epitope in human cell lines"
2943:
2902:
2865:
2826:
2785:
2753:
2720:
2683:
2654:
2623:
2582:
2543:
2508:
2500:
2465:
2455:
2414:
2379:
2369:
2320:
2291:
2206:
2196:
2154:
2146:
2105:
2095:
2032:
2024:
1897:
623:
465:
396:
340:
295:
440:
216:
1762:
1300:
2578:
2451:
2365:
2091:
2548:
2531:
2513:
2488:
2211:
2184:
2159:
2134:
2110:
2075:
2037:
2012:
1858:
2724:
2470:
2435:
2295:
1879:
1862:
1849:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
746:
741:
736:
731:
726:
710:
705:
700:
695:
685:
680:
675:
670:
665:
39:
3091:
3047:: HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE
2982:
2885:
2831:
2814:
2658:
2418:
2384:
2349:
1273:
666:
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
652:
2922:
2848:
2805:
2703:
2602:
2340:
1256:
458:
237:
3077:: DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK
3062:: DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK
2742:"Antigens recognized by autologous antibody in patients with renal-cell carcinoma"
200:
2586:
2100:
224:
2628:
2611:
1998:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1980:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1260:
2906:
2440:
Proceedings of the
National Academy of Sciences of the United States of America
2354:
Proceedings of the
National Academy of Sciences of the United States of America
541:
2150:
1285:
Click on genes, proteins and metabolites below to link to respective articles.
357:
254:
204:
1938:
ENSG00000288299 GRCh38: Ensembl release 89: ENSG00000134333, ENSG00000288299
867:
601:
479:
424:
411:
323:
310:
212:
2957:
2948:
2931:
2914:
2877:
2840:
2797:
2767:
2460:
2374:
2220:
2201:
2168:
2119:
2759:
10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5
2732:
2695:
2687:
2666:
2637:
2594:
2557:
2522:
2479:
2426:
2393:
2332:
2303:
2273:
2251:
2046:
1213:
1208:
2930:
Pioli PA, Hamilton BJ, Connolly JE, Brewer G, Rigby WF (September 2002).
2610:
Maekawa M, Sudo K, Kobayashi A, Sugiyama E, Li SS, Kanno T (April 1994).
2487:
Chung FZ, Tsujibo H, Bhattacharyya U, Sharief FS, Li SS (November 1985).
2011:
Chung FZ, Tsujibo H, Bhattacharyya U, Sharief FS, Li SS (November 1985).
1197:
1016:
997:
2870:
10.1002/1097-0134(20010501)43:2<175::AID-PROT1029>3.0.CO;2-#
2434:
Gosti F, Marty MC, Courvalin JC, Maunoury R, Bornens M (February 1987).
690:
2987:
2977:
2324:
1904:
983:
934:
2790:
10.1002/1097-0142(20000701)89:1<152::AID-CNCR20>3.0.CO;2-T
2504:
2028:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
1181:
889:
2402:
17:
852:
848:
1236:
192:
3000:
632:
179:, GSD11, HEL-S-133P, LDH1, LDHM, PIG19, lactate dehydrogenase A
2996:
2074:
Miskimins WK, Ahn HJ, Kim JY, Ryu S, Jung YS, Choi JY (2014).
2348:
Scrable HJ, Johnson DK, Rinchik EM, Cavenee WK (March 1990).
2972:
Overview of all the structural information available in the
2489:"Genomic organization of human lactate dehydrogenase-A gene"
2013:"Genomic organization of human lactate dehydrogenase-A gene"
1761:
1299:
1877:
The interactive pathway map can be edited at WikiPathways:
2076:"Synergistic anti-cancer effect of phenformin and oxamate"
1255:
Lactate dehydrogenase A catalyzes the inter-conversion of
2813:
Boutet A, Altmeyer R, Héry C, Tardieu M (December 2000).
1243:, which exists as a tetramer. The other main subunit is
448:
2133:
Lu QY, Zhang L, Yee JK, Go VW, Lee WN (February 2015).
613:
2238:
Miyajima H, Shimizu T, Kaneko E (October 1992). "".
2407:
2284:
1138:
1101:
1071:
1034:
1954:
1952:
1950:
1933:
1931:
1929:
1896:The following compounds have been demonstrated to
1232:) is an enzyme which in humans is encoded by the
395:
294:
2401:Maekawa M, Sudo K, Kanno T, Li SS (April 1990).
2986:(Human L-lactate dehydrogenase A chain) at the
1765:
1303:
1959:GRCm38: Ensembl release 89: ENSMUSG00000063229
1263:with concomitant inter-conversion of NADH and
3012:
8:
2530:Tsujibo H, Tiano HF, Li SS (February 1985).
2061:"Entrez Gene: LDHA lactate dehydrogenase A"
3019:
3005:
2997:
863:
648:
436:
335:
232:
74:
2947:
2830:
2757:
2627:
2547:
2512:
2469:
2459:
2383:
2373:
2210:
2200:
2158:
2109:
2099:
2036:
823:positive regulation of apoptotic process
3034:
1925:
1870:
763:post-embryonic animal organ development
29:
1848:|alt=Glycolysis and Gluconeogenesis
400:
361:
356:
299:
258:
253:
7:
783:response to organic cyclic compound
584:medial head of gastrocnemius muscle
2549:10.1111/j.1432-1033.1985.tb08711.x
1135:
1098:
1068:
1031:
1007:
988:
962:
939:
913:
894:
618:
536:
474:
453:
25:
1880:"GlycolysisGluconeogenesis_WP534"
798:carboxylic acid metabolic process
3067:
3052:
3037:
2832:10.1097/00002030-200012010-00008
2536:European Journal of Biochemistry
1861:Glycolysis and Gluconeogenesis
706:L-lactate dehydrogenase activity
622:
384:
377:
371:
348:
283:
276:
270:
245:
38:
2936:Journal of Biological Chemistry
2746:International Journal of Cancer
838:carbohydrate metabolic process
676:lactate dehydrogenase activity
633:More reference expression data
602:More reference expression data
1:
2725:10.1016/S0378-1119(97)00411-3
2296:10.1016/S0006-291X(05)81177-5
833:response to hydrogen peroxide
369:
268:
3098:Genes on human chromosome 11
2659:10.1016/0378-1119(94)90802-8
2587:10.1126/science.176.4031.180
2419:10.1016/0006-291X(90)92374-9
2101:10.1371/journal.pone.0085576
788:substantia nigra development
3119:
2907:10.1080/135502801753170318
2262:Biochemistry International
818:pyruvate metabolic process
580:sternocleidomastoid muscle
3032:
2629:10.1093/clinchem/40.4.665
2151:10.1007/s11306-014-0672-8
1994:"Mouse PubMed Reference:"
1976:"Human PubMed Reference:"
1212:
1207:
1203:
1196:
1180:
1161:
1142:
1105:
1094:
1075:
1038:
1027:
1014:
1010:
995:
991:
982:
969:
965:
946:
942:
933:
920:
916:
901:
897:
888:
873:
866:
862:
846:
768:lactate metabolic process
696:identical protein binding
651:
647:
630:
621:
612:
599:
548:
539:
486:
477:
447:
439:
435:
418:
405:
368:
347:
338:
334:
317:
304:
267:
244:
235:
231:
186:
183:
173:
166:
161:
82:
77:
60:
55:
50:
46:
37:
32:
2895:Journal of NeuroVirology
2409:(Submitted manuscript).
1910:Epigallocatechin gallate
1167:Chr 11: 18.39 – 18.41 Mb
2189:Cancer & Metabolism
1915:Quinoline 3-sulfonamide
1280:Interactive pathway map
1245:lactate dehydrogenase B
1226:Lactate dehydrogenase A
1174:Chr 7: 46.49 – 46.51 Mb
701:oxidoreductase activity
576:vastus lateralis muscle
2949:10.1074/jbc.M204002200
2461:10.1073/pnas.84.4.1000
2375:10.1073/pnas.87.6.2182
2202:10.1186/2049-3002-1-19
1842:
1380:
572:triceps brachii muscle
3103:Genes mutated in mice
2688:10.1212/wnl.43.7.1414
1841:
1379:
1269:lactate dehydrogenase
1241:Lactate dehydrogenase
1239:. It is a monomer of
808:NAD metabolic process
737:extracellular exosome
261:Chromosome 11 (human)
813:response to estrogen
793:response to nutrient
526:gastrocnemius muscle
363:Chromosome 7 (mouse)
78:List of PDB id codes
51:Available structures
2579:1972Sci...176..180G
2493:Biochemical Journal
2452:1987PNAS...84.1000G
2366:1990PNAS...87.2182S
2092:2014PLoSO...985576M
2017:Biochemical Journal
803:response to glucose
773:response to hypoxia
522:right adrenal gland
514:epithelium of colon
402:7 B3|7 30.6 cM
2616:Clinical Chemistry
2325:10.1007/BF00204925
2240:Rinsho Shinkeigaku
1843:
1381:
972:ENSMUSG00000063229
778:glycolytic process
756:Biological process
720:Cellular component
691:catalytic activity
659:Molecular function
3085:
3084:
2505:10.1042/bj2310537
2029:10.1042/bj2310537
1900:the LDHA enzyme:
1223:
1222:
1219:
1218:
1192:
1191:
1157:
1156:
1132:
1131:
1090:
1089:
1065:
1064:
1023:
1022:
1004:
1003:
978:
977:
959:
958:
929:
928:
910:
909:
858:
857:
643:
642:
639:
638:
608:
607:
595:
594:
533:
532:
431:
430:
330:
329:
157:
156:
153:
152:
61:Ortholog search:
16:(Redirected from
3110:
3071:
3056:
3041:
3021:
3014:
3007:
2998:
2961:
2951:
2942:(38): 35738–45.
2926:
2889:
2852:
2834:
2809:
2771:
2761:
2736:
2707:
2670:
2641:
2631:
2606:
2561:
2551:
2526:
2516:
2483:
2473:
2463:
2430:
2397:
2387:
2377:
2344:
2307:
2277:
2255:
2225:
2224:
2214:
2204:
2179:
2173:
2172:
2162:
2130:
2124:
2123:
2113:
2103:
2071:
2065:
2064:
2057:
2051:
2050:
2040:
2008:
2002:
2001:
1990:
1984:
1983:
1972:
1966:
1956:
1945:
1935:
1884:
1883:
1875:
1757:
1752:
1747:
1742:
1737:
1732:
1727:
1722:
1717:
1712:
1707:
1702:
1697:
1692:
1687:
1682:
1677:
1672:
1667:
1662:
1657:
1652:
1647:
1642:
1637:
1632:
1627:
1622:
1617:
1612:
1607:
1602:
1597:
1592:
1587:
1582:
1577:
1572:
1567:
1562:
1557:
1552:
1547:
1542:
1537:
1532:
1527:
1522:
1517:
1512:
1507:
1502:
1497:
1492:
1487:
1482:
1477:
1472:
1467:
1462:
1457:
1452:
1447:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1387:
1205:
1204:
1176:
1169:
1152:
1136:
1127:
1099:
1095:RefSeq (protein)
1085:
1069:
1060:
1032:
1008:
989:
963:
940:
914:
895:
864:
828:response to cAMP
711:cadherin binding
649:
635:
626:
619:
604:
560:primitive streak
544:
542:Top expressed in
537:
490:ventricular zone
482:
480:Top expressed in
475:
454:
437:
427:
414:
403:
388:
381:
375:
364:
352:
336:
326:
313:
302:
287:
280:
274:
263:
249:
233:
227:
225:LDHA - orthologs
178:
171:
148:
75:
69:
48:
47:
42:
30:
21:
3118:
3117:
3113:
3112:
3111:
3109:
3108:
3107:
3088:
3087:
3086:
3081:
3078:
3072:
3063:
3057:
3048:
3042:
3028:
3025:
2994:
2969:
2964:
2929:
2892:
2855:
2825:(17): 2687–97.
2812:
2774:
2739:
2719:(1–2): 149–56.
2710:
2673:
2644:
2609:
2573:(4031): 180–1.
2564:
2529:
2486:
2433:
2400:
2347:
2310:
2280:
2258:
2246:(10): 1087–92.
2237:
2233:
2231:Further reading
2228:
2181:
2180:
2176:
2132:
2131:
2127:
2073:
2072:
2068:
2059:
2058:
2054:
2010:
2009:
2005:
1992:
1991:
1987:
1974:
1973:
1969:
1957:
1948:
1936:
1927:
1923:
1894:
1892:LDHA Inhibitors
1889:
1888:
1887:
1878:
1876:
1872:
1867:
1866:
1865:
1860:
1855:
1854:
1853:
1847:
1846:
1845:
1844:
1840:
1759:
1758:
1755:
1753:
1750:
1748:
1745:
1743:
1740:
1738:
1735:
1733:
1730:
1728:
1725:
1723:
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1718:
1715:
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1710:
1708:
1705:
1703:
1700:
1698:
1695:
1693:
1690:
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1685:
1683:
1680:
1678:
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1670:
1668:
1665:
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1660:
1658:
1655:
1653:
1650:
1648:
1645:
1643:
1640:
1638:
1635:
1633:
1630:
1628:
1625:
1623:
1620:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1578:
1575:
1573:
1570:
1568:
1565:
1563:
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1533:
1530:
1528:
1525:
1523:
1520:
1518:
1515:
1513:
1510:
1508:
1505:
1503:
1500:
1498:
1495:
1493:
1490:
1488:
1485:
1483:
1480:
1478:
1475:
1473:
1470:
1468:
1465:
1463:
1460:
1458:
1455:
1453:
1450:
1448:
1445:
1443:
1440:
1438:
1435:
1433:
1430:
1428:
1425:
1423:
1420:
1418:
1415:
1413:
1410:
1408:
1405:
1403:
1400:
1398:
1395:
1393:
1390:
1388:
1385:
1382:
1378:
1282:
1253:
1214:View/Edit Mouse
1209:View/Edit Human
1172:
1165:
1162:Location (UCSC)
1148:
1144:
1123:
1119:
1115:
1111:
1107:
1081:
1077:
1056:
1052:
1048:
1044:
1040:
953:ENSG00000288299
951:
949:ENSG00000134333
842:
751:
715:
686:protein binding
631:
600:
591:
586:
582:
578:
574:
570:
566:
562:
558:
554:
540:
529:
524:
520:
518:ascending aorta
516:
512:
510:Achilles tendon
508:
504:
502:skin of abdomen
500:
498:tibial arteries
496:
492:
478:
422:
409:
401:
391:
390:
389:
382:
362:
339:Gene location (
321:
308:
300:
290:
289:
288:
281:
259:
236:Gene location (
187:
174:
167:
84:
62:
28:
23:
22:
15:
12:
11:
5:
3116:
3114:
3106:
3105:
3100:
3090:
3089:
3083:
3082:
3080:
3079:
3073:
3066:
3064:
3058:
3051:
3049:
3043:
3036:
3033:
3030:
3029:
3026:
3024:
3023:
3016:
3009:
3001:
2992:
2991:
2968:
2967:External links
2965:
2963:
2962:
2927:
2890:
2853:
2810:
2772:
2737:
2708:
2671:
2653:(1–2): 171–4.
2642:
2607:
2562:
2527:
2484:
2431:
2398:
2345:
2313:Human Genetics
2308:
2290:(2): 1083–90.
2278:
2256:
2234:
2232:
2229:
2227:
2226:
2174:
2125:
2066:
2052:
2003:
1985:
1967:
1946:
1924:
1922:
1919:
1918:
1917:
1912:
1907:
1893:
1890:
1886:
1885:
1869:
1868:
1857:
1856:
1760:
1754:
1749:
1744:
1739:
1734:
1729:
1724:
1719:
1714:
1709:
1704:
1699:
1694:
1689:
1684:
1679:
1674:
1669:
1664:
1659:
1654:
1649:
1644:
1639:
1634:
1629:
1624:
1619:
1614:
1609:
1604:
1599:
1594:
1589:
1584:
1579:
1574:
1569:
1564:
1559:
1554:
1549:
1544:
1539:
1534:
1529:
1524:
1519:
1514:
1509:
1504:
1499:
1494:
1489:
1484:
1479:
1474:
1469:
1464:
1459:
1454:
1449:
1444:
1439:
1434:
1429:
1424:
1419:
1414:
1409:
1404:
1399:
1394:
1389:
1384:
1383:
1298:
1297:
1296:
1295:
1293:
1292:
1291:
1290:
1289:
1288:
1281:
1278:
1252:
1249:
1221:
1220:
1217:
1216:
1211:
1201:
1200:
1194:
1193:
1190:
1189:
1187:
1185:
1178:
1177:
1170:
1163:
1159:
1158:
1155:
1154:
1140:
1139:
1133:
1130:
1129:
1103:
1102:
1096:
1092:
1091:
1088:
1087:
1073:
1072:
1066:
1063:
1062:
1036:
1035:
1029:
1025:
1024:
1021:
1020:
1012:
1011:
1005:
1002:
1001:
993:
992:
986:
980:
979:
976:
975:
967:
966:
960:
957:
956:
944:
943:
937:
931:
930:
927:
926:
918:
917:
911:
908:
907:
899:
898:
892:
886:
885:
880:
875:
871:
870:
860:
859:
856:
855:
844:
843:
841:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
759:
757:
753:
752:
750:
749:
744:
739:
734:
729:
723:
721:
717:
716:
714:
713:
708:
703:
698:
693:
688:
683:
681:kinase binding
678:
673:
668:
662:
660:
656:
655:
645:
644:
641:
640:
637:
636:
628:
627:
616:
610:
609:
606:
605:
597:
596:
593:
592:
590:
589:
585:
581:
577:
573:
569:
565:
561:
557:
553:
549:
546:
545:
534:
531:
530:
528:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
487:
484:
483:
471:
470:
462:
451:
445:
444:
441:RNA expression
433:
432:
429:
428:
420:
416:
415:
407:
404:
399:
393:
392:
383:
376:
370:
366:
365:
360:
354:
353:
345:
344:
332:
331:
328:
327:
319:
315:
314:
306:
303:
298:
292:
291:
282:
275:
269:
265:
264:
257:
251:
250:
242:
241:
229:
228:
185:
181:
180:
172:
164:
163:
159:
158:
155:
154:
151:
150:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
27:Type of enzyme
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3115:
3104:
3101:
3099:
3096:
3095:
3093:
3076:
3070:
3065:
3061:
3055:
3050:
3046:
3040:
3035:
3031:
3022:
3017:
3015:
3010:
3008:
3003:
3002:
2999:
2995:
2989:
2985:
2984:
2979:
2975:
2971:
2970:
2966:
2959:
2955:
2950:
2945:
2941:
2937:
2933:
2928:
2924:
2920:
2916:
2912:
2908:
2904:
2901:(5): 454–65.
2900:
2896:
2891:
2887:
2883:
2879:
2875:
2871:
2867:
2864:(2): 175–85.
2863:
2859:
2854:
2850:
2846:
2842:
2838:
2833:
2828:
2824:
2820:
2816:
2811:
2807:
2803:
2799:
2795:
2791:
2787:
2784:(1): 152–64.
2783:
2779:
2773:
2769:
2765:
2760:
2755:
2752:(4): 456–64.
2751:
2747:
2743:
2738:
2734:
2730:
2726:
2722:
2718:
2714:
2709:
2705:
2701:
2697:
2693:
2689:
2685:
2682:(7): 1414–9.
2681:
2677:
2672:
2668:
2664:
2660:
2656:
2652:
2648:
2643:
2639:
2635:
2630:
2625:
2621:
2617:
2613:
2608:
2604:
2600:
2596:
2592:
2588:
2584:
2580:
2576:
2572:
2568:
2563:
2559:
2555:
2550:
2545:
2541:
2537:
2533:
2528:
2524:
2520:
2515:
2510:
2506:
2502:
2499:(3): 537–41.
2498:
2494:
2490:
2485:
2481:
2477:
2472:
2467:
2462:
2457:
2453:
2449:
2446:(4): 1000–4.
2445:
2441:
2437:
2432:
2428:
2424:
2420:
2416:
2413:(2): 677–82.
2412:
2408:
2404:
2399:
2395:
2391:
2386:
2381:
2376:
2371:
2367:
2363:
2360:(6): 2182–6.
2359:
2355:
2351:
2346:
2342:
2338:
2334:
2330:
2326:
2322:
2318:
2314:
2309:
2305:
2301:
2297:
2293:
2289:
2285:
2279:
2275:
2271:
2268:(6): 1051–7.
2267:
2263:
2257:
2253:
2249:
2245:
2241:
2236:
2235:
2230:
2222:
2218:
2213:
2208:
2203:
2198:
2194:
2190:
2186:
2178:
2175:
2170:
2166:
2161:
2156:
2152:
2148:
2144:
2140:
2136:
2129:
2126:
2121:
2117:
2112:
2107:
2102:
2097:
2093:
2089:
2086:(1): e85576.
2085:
2081:
2077:
2070:
2067:
2062:
2056:
2053:
2048:
2044:
2039:
2034:
2030:
2026:
2023:(3): 537–41.
2022:
2018:
2014:
2007:
2004:
1999:
1995:
1989:
1986:
1981:
1977:
1971:
1968:
1964:
1960:
1955:
1953:
1951:
1947:
1943:
1939:
1934:
1932:
1930:
1926:
1920:
1916:
1913:
1911:
1908:
1906:
1903:
1902:
1901:
1899:
1891:
1881:
1874:
1871:
1864:
1859:
1851:
1764:
1302:
1287:
1286:
1279:
1277:
1275:
1274:myoglobinuria
1270:
1266:
1262:
1258:
1250:
1248:
1246:
1242:
1238:
1235:
1231:
1227:
1215:
1210:
1206:
1202:
1199:
1195:
1188:
1186:
1183:
1179:
1175:
1171:
1168:
1164:
1160:
1153:
1151:
1147:
1141:
1137:
1134:
1128:
1126:
1122:
1118:
1114:
1110:
1104:
1100:
1097:
1093:
1086:
1084:
1080:
1074:
1070:
1067:
1061:
1059:
1055:
1051:
1047:
1043:
1037:
1033:
1030:
1028:RefSeq (mRNA)
1026:
1019:
1018:
1013:
1009:
1006:
1000:
999:
994:
990:
987:
985:
981:
974:
973:
968:
964:
961:
955:
954:
950:
945:
941:
938:
936:
932:
925:
924:
919:
915:
912:
906:
905:
900:
896:
893:
891:
887:
884:
881:
879:
876:
872:
869:
865:
861:
854:
850:
845:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
760:
758:
755:
754:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
724:
722:
719:
718:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
663:
661:
658:
657:
654:
653:Gene ontology
650:
646:
634:
629:
625:
620:
617:
615:
611:
603:
598:
587:
583:
579:
575:
571:
567:
563:
559:
555:
551:
550:
547:
543:
538:
535:
525:
521:
517:
513:
509:
506:muscle of leg
505:
501:
497:
493:
489:
488:
485:
481:
476:
473:
472:
469:
467:
463:
461:
460:
456:
455:
452:
450:
446:
442:
438:
434:
426:
421:
417:
413:
408:
398:
394:
387:
380:
374:
367:
359:
355:
351:
346:
342:
337:
333:
325:
320:
316:
312:
307:
297:
293:
286:
279:
273:
266:
262:
256:
252:
248:
243:
239:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
182:
177:
170:
165:
160:
149:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3074:
3059:
3044:
2993:
2981:
2939:
2935:
2898:
2894:
2861:
2857:
2822:
2818:
2781:
2777:
2749:
2745:
2716:
2712:
2679:
2675:
2650:
2646:
2622:(4): 665–8.
2619:
2615:
2570:
2566:
2539:
2535:
2496:
2492:
2443:
2439:
2410:
2406:
2357:
2353:
2316:
2312:
2287:
2283:
2265:
2261:
2243:
2239:
2192:
2188:
2177:
2145:(1): 71–80.
2142:
2139:Metabolomics
2138:
2128:
2083:
2079:
2069:
2055:
2020:
2016:
2006:
1997:
1988:
1979:
1970:
1895:
1873:
1284:
1283:
1254:
1233:
1229:
1225:
1224:
1146:NP_001129541
1143:
1121:NP_001158888
1117:NP_001158887
1113:NP_001158886
1109:NP_001128711
1106:
1079:NM_001136069
1076:
1054:NM_001165416
1050:NM_001165415
1046:NM_001165414
1042:NM_001135239
1039:
1015:
996:
970:
947:
921:
902:
882:
877:
564:otic vesicle
552:otic placode
464:
457:
184:External IDs
83:
3027:PDB gallery
2542:(1): 9–15.
2319:(1): 34–8.
671:NAD binding
494:skin of leg
423:46,505,051
410:46,490,899
322:18,408,425
309:18,394,560
162:Identifiers
3092:Categories
1965:, May 2017
1944:, May 2017
1921:References
468:(ortholog)
205:HomoloGene
2886:196599144
2676:Neurology
2195:(1): 19.
1150:NP_034829
1125:NP_005557
1083:NM_010699
1058:NM_005566
868:Orthologs
727:cytoplasm
213:GeneCards
2958:12107167
2923:12958486
2915:11582518
2878:11276087
2858:Proteins
2849:12747999
2841:11125887
2806:44477008
2798:10897012
2768:10508479
2704:41011165
2603:20224553
2341:19321774
2221:24280423
2169:26246802
2120:24465604
2080:PLOS ONE
1961:–
1940:–
1257:pyruvate
1251:Function
1247:(LDHB).
1198:Wikidata
847:Sources:
732:membrane
568:epiblast
2988:PDBe-KB
2978:UniProt
2733:9373149
2696:8327147
2667:8125298
2638:7908613
2595:5014440
2575:Bibcode
2567:Science
2558:3838278
2523:3000353
2514:1152784
2480:2434947
2448:Bibcode
2427:2334430
2394:2315312
2362:Bibcode
2333:1959923
2304:1953713
2274:1445373
2252:1297552
2212:4178217
2160:4523095
2111:3897486
2088:Bibcode
2047:3000353
2038:1152784
1963:Ensembl
1942:Ensembl
1905:Oxamate
1898:inhibit
1294:[[File:
1261:lactate
984:UniProt
935:Ensembl
874:Species
853:QuickGO
747:cytosol
742:nucleus
588:saccule
443:pattern
301:11p15.1
169:Aliases
2983:P00338
2956:
2921:
2913:
2884:
2876:
2847:
2839:
2804:
2796:
2778:Cancer
2766:
2731:
2702:
2694:
2665:
2636:
2601:
2593:
2556:
2521:
2511:
2478:
2471:304349
2468:
2425:
2392:
2382:
2339:
2331:
2302:
2272:
2250:
2219:
2209:
2167:
2157:
2118:
2108:
2045:
2035:
1259:and L-
1184:search
1182:PubMed
1017:P06151
998:P00338
890:Entrez
614:BioGPS
556:somite
193:150000
2919:S2CID
2882:S2CID
2845:S2CID
2802:S2CID
2700:S2CID
2599:S2CID
2385:53650
2337:S2CID
923:16828
883:Mouse
878:Human
849:Amigo
466:Mouse
459:Human
406:Start
341:Mouse
305:Start
238:Human
209:56495
201:96759
3075:9ldt
3060:9ldb
3045:1i10
2976:for
2954:PMID
2911:PMID
2874:PMID
2837:PMID
2819:AIDS
2794:PMID
2764:PMID
2729:PMID
2713:Gene
2692:PMID
2663:PMID
2647:Gene
2634:PMID
2591:PMID
2554:PMID
2519:PMID
2476:PMID
2423:PMID
2390:PMID
2329:PMID
2300:PMID
2270:PMID
2248:PMID
2217:PMID
2165:PMID
2116:PMID
2043:PMID
1863:edit
1850:edit
1237:gene
1234:LDHA
1230:LDHA
904:3939
449:Bgee
397:Band
358:Chr.
296:Band
255:Chr.
217:LDHA
189:OMIM
176:LDHA
146:4ZVV
142:4RLS
138:4R69
134:4R68
130:4QT0
126:4QSM
122:4QO8
118:4QO7
114:4OKN
110:4OJN
106:4M49
102:4L4S
98:4L4R
94:4JNK
90:4AJP
86:1I10
67:RCSB
64:PDBe
33:LDHA
18:LDHA
2974:PDB
2944:doi
2940:277
2903:doi
2866:doi
2827:doi
2786:doi
2754:doi
2721:doi
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