1618:
29:
586:
474:
Lebourgeois S, Vilpoux C, Jeanblanc J, Acher F, Marie N, Noble F, Naassila M (May 2018). "Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat".
174:
579:
1598:
572:
1663:
1594:
216:
InChI=1S/C14H17F3NO9P/c15-14(16,17)27-10-5-7(1-2-9(10)26-6-11(19)20)13(23)28(24,25)4-3-8(18)12(21)22/h1-2,5,8,13,23H,3-4,6,18H2,(H,19,20)(H,21,22)(H,24,25)/t8-,13?/m0/s1
431:
Hajasova Z, Canestrelli C, Acher F, Noble F, Marie N (March 2018). "Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist".
188:
1152:
1011:
768:
1656:
520:"LSP2-9166, an orthosteric mGlu4 and mGlu7 receptor agonist, reduces cocaine self-administration under a progressive ratio schedule in rats"
1712:
1281:
882:
1649:
1497:
1398:
1326:
1222:
1073:
915:
729:
615:
268:
261:
254:
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208:
382:"Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy"
1687:
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906:
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595:
239:
44:
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763:
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De Sa
Nogueira D, Bourdy R, Filliol D, Quessada C, McCort-Tranchepain I, Acher F, et al. (November 2021).
1137:
989:
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500:
456:
1264:
979:
709:
704:
669:
341:"The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures"
339:
Girard B, Tuduri P, Moreno MP, Sakkaki S, Barboux C, Bouschet T, et al. (September 2019).
1571:
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674:
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1041:
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654:
380:
Kovalenko AA, Zakharova MV, Schwarz AP, Dyomina AV, Zubareva OE, Zaitsev AV (March 2022).
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381:
278:
effects in animal studies, and reduces self-administration of various addictive drugs.
275:
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959:
783:
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554:
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75:
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504:
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28:
538:
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892:
840:
825:
1536:
1276:
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1122:
1117:
1036:
1031:
974:
969:
964:
820:
800:
357:
340:
150:
86:
300:"Metabotropic glutamate receptor orthosteric ligands and their binding sites"
1521:
1422:
1345:
1241:
1199:
1107:
1102:
1063:
954:
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298:
Acher FC, Cabayé A, Eshak F, Goupil-Lamy A, Pin JP (February 2022).
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1016:
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1021:
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748:
634:
568:
52:(2S)-2-amino-4--hydroxymethyl]-hydroxyphosphoryl]butanoic acid
1498:
1399:
1327:
1223:
1074:
916:
730:
616:
1637:
196:
C1=CC(=C(C=C1C(O)P(=O)(CC(C(=O)O)N)O)OC(F)(F)F)OCC(=O)O
1496:
1397:
1325:
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728:
614:
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162:
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60:
35:
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8:
19:
386:International Journal of Molecular Sciences
1664:
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1218:
911:
611:
587:
573:
565:
94:
27:
1599:Glutamate metabolism/transport modulators
1506:Tooltip Metabotropic glutamate receptor 8
1407:Tooltip Metabotropic glutamate receptor 7
1335:Tooltip Metabotropic glutamate receptor 6
1231:Tooltip Metabotropic glutamate receptor 4
1082:Tooltip Metabotropic glutamate receptor 3
924:Tooltip Metabotropic glutamate receptor 2
738:Tooltip Metabotropic glutamate receptor 5
624:Tooltip Metabotropic glutamate receptor 1
407:
397:
356:
315:
1595:Ionotropic glutamate receptor modulators
290:
213:
193:
49:
18:
7:
1614:
1612:
234:is a drug which acts as a selective
1138:Pomaglumetad methionil (LY-2140023)
990:Pomaglumetad methionil (LY-2140023)
260:, and weaker activity of 1380nM at
65:
1636:. You can help Knowledge (XXG) by
143:
14:
1616:
489:10.1016/j.neuropharm.2018.01.031
445:10.1016/j.neuropharm.2018.01.002
317:10.1016/j.neuropharm.2021.108886
240:metabotropic glutamate receptors
134:
128:
122:
1534:Positive allosteric modulators:
1485:Negative allosteric modulators:
1274:Positive allosteric modulators:
1192:Negative allosteric modulators:
1056:Negative allosteric modulators:
999:Positive allosteric modulators:
855:Negative allosteric modulators:
798:Positive allosteric modulators:
596:Metabotropic glutamate receptor
221:Key:NTRJZUQSNSIKLO-OADYLZGLSA-N
137:
116:
1:
1591:Receptor/signaling modulators
242:, with a reasonably potent EC
539:10.1016/j.neulet.2020.135603
1729:
1611:
106:Chemical and physical data
1713:Nervous system drug stubs
1584:
1123:LY-404,039 (pomaglumetad)
970:LY-404,039 (pomaglumetad)
358:10.1016/j.nbd.2019.04.016
204:
184:
40:
26:
1628:article relating to the
1002:JNJ-40411813 (ADX-71149)
1688:MGlu7 receptor agonists
1683:MGlu4 receptor agonists
345:Neurobiology of Disease
1693:Trifluoromethyl ethers
527:Neuroscience Letters
399:10.3390/ijms23052752
23:
1698:Dicarboxylic acids
238:for the group III
1703:Alpha-Amino acids
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477:Neuropharmacology
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304:Neuropharmacology
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175:Interactive image
16:Chemical compound
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789:Quisqualic acid
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276:anticonvulsant
270:
267:and 4800nM at
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1113:Ibotenic acid
1111:
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960:Ibotenic acid
958:
956:
953:
951:
948:
946:
943:
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930:
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829:
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817:
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809:
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799:
795:
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790:
787:
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784:Ibotenic acid
782:
780:
777:
775:
772:
770:
767:
765:
762:
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755:
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750:
747:
744:
743:
741:
736:
727:
721:
718:
716:
713:
711:
708:
706:
703:
701:
700:Cyclothiazide
698:
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693:
691:
688:
685:
684:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
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653:
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650:Ibotenic acid
648:
646:
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641:
638:
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630:
629:
627:
622:
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608:
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259:
253:and 220nM at
252:
241:
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194:
190:
183:
176:
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109:
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84:
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72:
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63:
59:
50:
46:
39:
34:
30:
25:
1708:Phosphinates
1638:expanding it
1623:
1608:
1587:
1586:
1544:Antagonists:
1543:
1533:
1513:
1484:
1443:Antagonists:
1442:
1435:
1414:
1361:Antagonists:
1360:
1342:
1289:Antagonists:
1288:
1273:
1254:
1238:
1191:
1150:Antagonists:
1149:
1143:Talaglumetad
1089:
1055:
1009:Antagonists:
1008:
998:
995:Talaglumetad
931:
868:Dipraglurant
863:Basimglurant
854:
808:Antagonists:
807:
797:
745:
687:Antagonists:
686:
631:
530:
526:
513:
480:
476:
469:
436:
432:
426:
389:
385:
375:
348:
344:
334:
307:
303:
293:
280:
231:
230:
1270:VU-0155,041
1195:Decoglurant
1059:Decoglurant
893:Raseglurant
841:Remeglurant
826:Mavoglurant
690:BAY 36-7620
483:: 163–170.
439:: 424–430.
392:(5): 2752.
246:of 70nM at
158: g·mol
36:Identifiers
1677:Categories
1537:AZ12216052
1277:Foliglurax
1265:VU-001,171
1178:LY-341,495
1173:LY-307,452
1128:LY-487,379
1118:LY-379,268
1037:LY-341,495
1032:LY-307,452
980:LY-566,332
975:LY-487,379
965:LY-379,268
821:LY-344,545
801:LSN2463359
710:LY-456,236
705:LY-367,385
599:modulators
533:: 135603.
310:: 108886.
285:References
163:3D model (
151:Molar mass
87:ChemSpider
45:IUPAC name
1588:See also:
1522:Glutamate
1514:Agonists:
1436:LSP2-9166
1423:Glutamate
1415:Agonists:
1346:Glutamate
1343:Agonists:
1255:LSP2-9166
1242:Glutamate
1239:Agonists:
1214:Group III
1200:RO4491533
1108:Glutamate
1103:Eglumegad
1090:Agonists:
1064:RO4491533
955:Glutamate
950:Eglumegad
932:Agonists:
779:Glutamate
754:ADX-47273
746:Agonists:
670:Ro67-7476
665:Ro67-4853
660:Ro01-6128
645:Glutamate
632:Agonists:
555:229724310
351:: 13–28.
274:. It has
232:LSP2-9166
21:LSP2-9166
1572:UBP-1112
1488:ADX71743
1476:UBP-1112
1389:UBP-1112
1317:UBP-1112
1188:MGS-0039
1133:MGS-0028
1047:MGS-0039
985:MGS-0028
907:Group II
851:SIB-1893
846:SIB-1757
836:NPS-2390
720:NPS-2390
680:Theanine
547:33387661
497:29378211
453:29307544
418:35269897
367:31051234
326:34813860
96:98651888
76:71042034
878:GRN-529
873:Fenobam
858:AZD9272
794:VU-1545
695:CPCCOEt
607:Group I
505:3959313
461:3391450
409:8910969
236:agonist
156:431.257
112:Formula
62:PubChem
1481:XAP044
1418:AMN082
1098:DCG-IV
1093:CBiPES
1052:PCCG-4
945:DCG-IV
940:CBiPES
553:
545:
503:
495:
459:
451:
416:
406:
365:
324:
189:SMILES
1632:is a
1624:This
1499:mGluR
1456:MMPIP
1400:mGluR
1328:mGluR
1260:PHCCC
1224:mGluR
1168:HYDIA
1158:CECXG
1153:APICA
1075:mGluR
1027:HYDIA
1017:CECXG
1012:APICA
917:mGluR
816:DMeOB
759:CDPPB
731:mGluR
675:VU-71
617:mGluR
551:S2CID
523:(PDF)
501:S2CID
457:S2CID
269:mGluR
262:mGluR
255:mGluR
248:mGluR
209:InChI
165:JSmol
1634:stub
1626:drug
1567:MTPG
1562:MSOP
1557:MPPG
1552:MAP4
1547:CPPG
1530:-AP4
1517:DCPG
1471:MTPG
1466:MSOP
1461:MPPG
1451:MAP4
1446:CPPG
1431:-AP4
1384:MTPG
1379:MSOP
1374:MPPG
1369:MAP4
1364:CPPG
1354:-AP4
1312:MTPG
1307:MSOP
1302:MPPG
1297:MAP4
1292:CPPG
1282:MPEP
1250:-AP4
1183:MCPG
1163:EGLU
1042:MCPG
1022:EGLU
935:BINA
888:MTEP
883:MPEP
831:MCPG
811:CTEP
774:DHPG
764:CHPG
749:ACPD
715:MCPG
640:DHPG
635:ACPD
543:PMID
493:PMID
449:PMID
414:PMID
363:PMID
322:PMID
769:DFB
535:doi
531:764
485:doi
481:133
441:doi
437:131
404:PMC
394:doi
353:doi
349:129
312:doi
308:204
66:CID
1679::
1597:•
1593:•
1532:;
1483:;
1272:;
1190:;
1054:;
997:;
853:;
796:;
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244:50
126:17
120:14
1665:e
1658:t
1651:v
1640:.
1528:L
1501:8
1429:L
1402:7
1352:L
1330:6
1248:L
1226:4
1077:3
919:2
733:5
619:1
588:e
581:t
574:v
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271:8
264:6
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250:4
167:)
144:P
141:9
138:O
135:N
132:3
129:F
123:H
117:C
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