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8th in the UK in
Biosciences in the 2012 Guardian University Guide, and Chemistry, which had been threatened with closure in 2006, has been revitalised with the appointment of new Faculty in Organic and Synthetic Chemistry, and with the launch of a university-funded initiative in Medicinal Chemistry and Drug Discovery.
508:
On arrival at Sussex he undertook the restructuring of the School of Life
Sciences which resulted in nearly one third of the faculty accepting early retirement or leaving the university, and rationalised the degree programs, stopping a number of poorly-recruiting Masters programmes. Sussex now ranks
630:
for his significant contributions to our understanding of the biochemical and structural basis for assembly, specificity and regulation of the proteins and complexes that carry out DNA repair and DNA damage signalling, signal transduction, and chaperone-dependent protein activation.
504:
He is a founder and CSO of
Domainex Ltd, an innovative biotech company that won the 2010 Life Sciences and Enterprise Programme of The Year Award, and the "Innovation in Enabling Biotechnology" Prize at 2007 UKTI Bioentrepreneurial Company of the Year Awards.
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Laurence Pearl has applied structural, biochemical and genetic techniques, to elucidate the molecular basis of function and specificity in systems of fundamental biomedical importance. His pioneering work on
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molecular chaperone system. Although focussed on understanding basic mechanisms, his laboratory is committed to translating this understanding to the discovery of new drugs for patient benefit.
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His research focuses on understanding the structural basis for assembly, specificity and regulation of proteins and complexes involved in human diseases such as
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Sussex ranked 10th overall in the UK for
Biological Sciences, and 8th for research outputs in the 2014 Research Excellence Framework (
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588:-coupled molecular clamp that drives the chaperone cycle. In his research on cell signalling he has determined the structure of
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who is currently
Professor of Structural Biology in the Genome Damage and Stability Centre and was Head of the School of
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Pearl, L. H.; Prodromou, C; Workman, P (2008). "The Hsp90 molecular chaperone: An open and shut case for treatment".
733:
Who's Who 2014, A & C Black, an imprint of
Bloomsbury Publishing plc, 2014; online edn, Oxford University Press
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to chair the new
Section of Structural Biology (jointly with David Barford) at the Chester Beatty Laboratories in
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870:"Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone"
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team who were semi-finalists in 1984, and achieved the 2nd highest score in the show's history - 430 against
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Pearl, L. H.; Prodromou, C (2006). "Structure and mechanism of the Hsp90 molecular chaperone machinery".
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In 2017 he announced that he would be standing down as Head of the School of Life
Sciences at Sussex.
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Genome Damage and
Stability Centre, where he holds the position of Professor of Structural Biology.
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From 1 October he took up a joint appointment as Head of the
Division of Structural Biology at the
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516:), placing it on par with Cambridge and ahead of the majority of Russell Group Universities.
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568:. He has made seminal contributions to our understanding of the recognition and repair of
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Prodromou, C; Roe, S. M.; O'Brien, R; Ladbury, J. E.; Piper, P. W.; Pearl, L. H. (1997).
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592:-beta, showing how it recognises substates, and elucidating how it is inhibited through
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Pearl, L. H.; Taylor, W. R. (1987). "A structural model for the retroviral proteases".
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1166:"Results & submissions : REF 2014 : View results and submissions by UOA"
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as a new target for cancer therapy and for their role in development of the drug
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in 2012. In 2011 he was awarded an inaugural Senior Investigator Award by the
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and then Professor of Structural Biology in 1996. In 1999 he rejoined the
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where he was very active in school drama productions, appearing alongside
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In 2009 he was appointed Head of the new School of Life Sciences at the
1021:
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Laurence Pearl was awarded the 2018 Novartis Medal and Prize from the
305:
841:
770:
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983:"Chemical & Engineering News: Cover Story - Living on the Edge"
856:
428:, he returned to UCL as lecturer in Biochemistry in 1989, becoming
857:
Laurence Pearl appears in Stephen Curry's film - "I'm a Scientist"
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576:, he was the first to show its function depended on binding and
355:
Born in Manchester to a working class Jewish family, he went to
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and cancer. He is particularly noted for his early work on the
1646:
Fellows of the Academy of Medical Sciences (United Kingdom)
654:"EC/2008/32 Pearl, Laurence: Library and Archive Catalogue"
604:
Translational Cancer Research Prize along with the team of
461:
while continuing as Professor of Structural Biology in the
1152:"Sussex Drug Discovery Centre : University of Sussex"
1234:"The Novartis Medal and Prize | Biochemical Society"
1180:"Wellcome funds 'outstanding' cancer research at Sussex"
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Members of the European Molecular Biology Organization
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http://www.embo.org/embo-members/find-a-member.html
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600:Pearl and his research team were awarded the 2013
175:Novartis Medal of the Biochemical Society (2017)
701:
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526:European Molecular Biology Organisation (EMBO)
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1118:"Sussex's future: Fewer staff, more students"
544:. His nomination for the Royal Society reads
8:
1641:People educated at Manchester Grammar School
1595:David Sainsbury, Baron Sainsbury of Turville
952:"Head of School of Life Sciences steps down"
1651:Academics of Birkbeck, University of London
656:. London: The Royal Society. Archived from
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923:Crystallographic studies of endothiapepsin
274:Crystallographic studies of endothiapepsin
31:
20:
885:
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612:for their seminal work in developing the
817:10.1146/annurev.biochem.75.103004.142738
690:"2018 Award Winners | Biochemistry"
572:. In studies of the molecular chaperone
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524:Pearl was elected to membership of the
1656:Academics of University College London
1218:: CS1 maint: archived copy as title (
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1088:: CS1 maint: archived copy as title (
1081:
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584:, and he defined the mechanism of the
556:was a key step in the recognition of
538:Member of the Academia Europaea (MAE)
377:and PhD degrees in the Department of
7:
1621:People from Bury, Greater Manchester
1132:"University guide 2012: Biosciences"
938:"University Challenge - Statistics"
447:, relocating his laboratory to the
463:Genome Damage and Stability Centre
14:
331:(born 18 June 1956) is a British
926:(PhD thesis). Birkbeck College.
966:"Accredited Degree Programmes"
729:"PEARL, Prof. Laurence Harris"
1:
887:10.1016/S0092-8674(00)80314-1
838:Laurence Pearl's publications
805:Annual Review of Biochemistry
369:. Pearl read Biochemistry at
1636:Fellows of the Royal Society
610:Institute of Cancer Research
459:Institute of Cancer Research
434:Institute of Cancer Research
422:Institute of Cancer Research
258:Institute of Cancer Research
37:Laurence Pearl in his office
534:Fellow of the Royal Society
530:Academy of Medical Sciences
1682:
1666:Scientists from Manchester
528:in 2005, a Fellow of the
389:under the supervision of
371:University College London
357:Manchester Grammar School
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248:University College London
182:
79:University College London
30:
844:bibliographic database.
708:publications indexed by
366:The Government Inspector
846:(subscription required)
738:(subscription required)
485:, proteins involved in
473:Research and enterprise
598:
491:uracil-DNA glycosylase
402:Exeter College, Oxford
140:two sons, one daughter
1404:Christopher John Lamb
532:(FMedSci) in 2007, a
414:Postdoctoral research
393:. He was part of the
323:Laurence Harris Pearl
47:Laurence Harris Pearl
1549:William A. Catterall
1501:Claudio Daniel Stern
1297:Girish Saran Agarwal
660:on 16 February 2014.
536:(FRS) in 2008 and a
467:University of Sussex
445:University of Sussex
398:University Challenge
345:University of Sussex
337:structural biologist
253:University of Sussex
1200:on 10 November 2013
1120:. 27 November 2009.
1010:Biochemical Journal
763:1987Natur.329..351P
676:Find an EMBO member
628:Biochemical Society
617:molecular chaperone
132:Frances M. G. Pearl
1626:English biologists
1495:Philip J. Stephens
1467:Matthew Rosseinsky
1384:Christopher Hunter
1337:Alexander Bradshaw
1332:Leszek Borysiewicz
1022:10.1042/BJ20071640
602:Cancer Research UK
562:therapeutic target
520:Awards and honours
373:and then obtained
222:Genome instability
202:Structural Biology
1603:
1602:
1544:J. Michael Bishop
1364:Russell G. Foster
1044:"Management Team"
385:, for studies of
320:
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184:Scientific career
16:British biologist
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1506:Michael Stratton
1426:John C. Marshall
1409:Peter Simon Liss
1312:Fraser Armstrong
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1196:. Archived from
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1070:on 25 April 2012
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395:Birkbeck College
383:Birkbeck College
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286:Doctoral advisor
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84:Birkbeck College
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1389:Stephen Jackson
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840:indexed by the
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757:(6137): 351–4.
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361:Nicholas Hytner
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1484:James F. Scott
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1473:Robert Russell
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1462:Laurence Pearl
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1432:Harvey McMahon
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1140:. 16 May 2011.
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989:on 4 July 2008
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954:. 31 May 2017.
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710:Google Scholar
706:Laurence Pearl
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692:. 17 May 2019.
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542:Wellcome Trust
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483:HIV-1 protease
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59:(age 68)
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1564:Peter Marler
1559:Ho-Kwang Mao
1554:Barbara Hohn
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1444:Peter Parham
1442:
1438:Anne O'Garra
1430:
1420:Yiu-Wing Mai
1418:
1369:Brian Foster
1349:Fergus Craik
1341:
1302:Dario Alessi
1228:
1202:. Retrieved
1198:the original
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1104:"Press room"
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391:Tom Blundell
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291:Tom Blundell
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241:Institutions
232:Biochemistry
183:
97:biochemistry
57:18 June 1956
18:
1616:1956 births
1359:John Duncan
1204:10 November
596:signalling.
1610:Categories
1451:Ian Parker
1399:Mark Kisin
1374:Derek Fray
1327:Jon Blundy
1074:22 October
993:10 October
811:: 271–94.
635:References
578:hydrolysis
570:DNA damage
551:retroviral
487:DNA repair
412:Following
333:biochemist
212:DNA repair
207:Biophysics
112:DNA repair
93:Occupation
64:Manchester
53:1956-06-18
1322:John Bell
554:proteases
351:Education
312:/profiles
66:, England
1588:Honorary
1414:Jan Löwe
1281:elected
1214:cite web
1084:cite web
1030:18290764
920:(1984).
904:10240500
825:16756493
497:and the
495:DNA-PKcs
489:such as
479:HIV/AIDS
420:and the
227:Proteins
137:Children
106:Work on
1537:Foreign
1290:Fellows
1283:in 2008
1277:of the
1275:Fellows
896:9230303
787:4304846
779:3306411
759:Bibcode
608:at the
594:insulin
465:at the
438:Chelsea
343:at the
329:FMedSci
314:/243849
301:Website
158:FMedSci
115:Enzymes
1028:
902:
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842:Scopus
823:
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777:
751:Nature
621:AUY922
586:ATPase
430:Reader
408:Career
306:sussex
279:(1984)
277:
268:Thesis
190:Fields
172:(2012)
166:member
160:(2007)
154:(2008)
145:Awards
129:Spouse
1068:(PDF)
1061:(PDF)
969:(PDF)
900:S2CID
783:S2CID
614:Hsp90
590:GSK-3
574:Hsp90
560:as a
499:Hsp90
123:GSK-3
119:Hsp90
1220:link
1206:2013
1090:link
1076:2011
1026:PMID
995:2011
892:PMID
874:Cell
821:PMID
775:PMID
566:AIDS
493:and
335:and
164:EMBO
121:and
43:Born
1018:doi
1014:410
882:doi
813:doi
767:doi
755:329
582:ATP
580:of
564:in
514:REF
449:MRC
424:in
381:at
375:MSc
363:in
326:FRS
310:.uk
308:.ac
170:MAE
152:FRS
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