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diseases, Broncho-Pneumology, Infectology, Oncology, Neurology, Gastroenterology, Dermatology, Urology and
Gynecology, Malaria and Rare Diseases. The Group is a leader in the nutraceutical industry and produces supplements of high scientific interest. Its product range also includes high-end dermocosmetics lines, as well as oral and personal care products. Since 1998 it has filed 297 patents confirming itself, among the national Italian-owned, as a major player in the registration of new molecules or important technological innovations. The Sigma-Tau Group has headquarters in Pomezia (Rome, Italy), and subsidiaries in France, Switzerland, Belgium, the Netherlands, Germany, UK, and India, and with production plants in Italy as well as in Spain and US (Indianapolis). The ability to expand its presence on the international stage, mainly through the activation of collaborative research with numerous scientific institutions in America, Europe, and Asia, is the key to Sigma-Tau's future. Since the pioneering studies conducted by its founder Claudio Cavazza, Sigma-Tau has always proved to be a groundbreaker in the discovery of drugs for rare and orphan diseases: for instance, Carnitine for the treatment of primary or secondary “specific deficiencies” was the second product ever to obtain the designation as “orphan drug” by the US FDA. Leveraging this background, the company has confirmed its commitment to developing drugs with orphan indications over the years and has acquired Enzon's “specialty pharma” portfolio. With eight products for the treatment of rare and neglected diseases, today Sigma-Tau is a pharmaceutic player acting at the forefront in the treatment of Rare Diseases. The goal of its recently created Global Rare Disease Business Unit is to contribute to the progress in the knowledge, diagnosis, and treatment of Rare Diseases.
594:, formed with associations and bodies engaged – at national and international level – in projects and activities with a social emphasis, with particular focus on the areas of health and social welfare. The company also provides its medicines free-of-charge to around 40 national and international organizations operating in conflict and post-conflict contexts to support those people stricken by natural disasters and famine. At international level, Sigma-Tau:
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of an Orphan Drug
Designation, subsequently receiving another seven. With the discovery in the 1970s of Carnitine deficiency syndromes, an illness with a fatal outcome, Sigma-Tau focused the investigative efforts of its laboratories on research into a molecule capable of opposing the disease. This
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Incorporated in 1979 as part of the Sigma-Tau Group, Biosint is currently a world-leading producer of L-Carnitine derived by chemical synthesis. The company manufactures and distributes active pharmaceutical ingredients, lactic ferments and nutraceutical products obtained by chemical synthesis and
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thanks to a loophole in the EU laws that facilitated this due to an existing monopoly for this medicine. The discussion reached the EU parliament in 2018 when questioning about it. The US media referred to it back in the days and in late 2021 the topic has, again, been highlighted in the
Spanish
419:
The Sigma-Tau Group achieved a corporate turnover of 697 million euro in 2013, employs a workforce of 1,919 and possesses a portfolio of more than 100 products marketed in Italy and abroad, with regards to the following therapeutic areas: Cardiometabolic disorders, Orthopedic and
Rheumatologic
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accused the company of abusing its dominant market position when it increased the price of chenodeoxycholic acid from €0.28 per capsule to €140 per capsule in 2018. They said “This may be legal but it’s not socially acceptable.” They said they would make a referral to the
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While the company claims to operate in absolute respect of ethical principles and existing legislation it received a tremendous amount of negative attention due their action to increase the price of an orphan drug to such extent it became impossible to pay for the drug.
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Founded in 1982 and active both in the pharmaceutical market and that of consumer products sold in pharmacies. Avantgarde has developed its business within the dermatological, gynaecological and paediatric sectors; for consumer products the focus is geared to
787:
collaborates in providing information through Vita, the non-profit weekly magazine which aims to encourage the culture of solidarity and social responsibility, providing its readers with up-to-date, independent analysis of the voluntary
554:
In 1967 Sigma-Tau became equipped with a water conditioning plant. Since 2005, the commitment to reduce impact on the environment in the elimination of solvents in aid of water in many preparations has produced continuing reduction in
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for its headquarters created one of the first industrialization and urban development initiatives in an area of
Central-southern Italy that had previously been mainly devoted to agriculture. With the creation and launch of the
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From the 1970s onwards, Sigma-Tau focused on experimenting with new medicines for rare diseases – a commitment that in 1984 would cause it to become the fourth largest pharmaceutical company in the world and assignee in the
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fermentation. Its operations are carried out in full compliance with current good manufacturing practices (cGMP), at establishments approved by FDA and main domestic and international
Regulatory Authorities.
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Responsible for the research and development of substances active on important areas of treatment including oncology and immunology and on diseases that are rare, neglected and with high social impact.
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Orphan drugs are medicines that are effective in the treatment of certain diseases that are not manufactured or put on the market due to insufficient demand to cover production costs and supply.
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A recently established research centre that co-ordinates research and development activity relating to selected products and provides clinical development and chemical analytical expertise.
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participates in a program of solidarity to support with
Associazione Dynamo Camp, each year hosting around 1,000 children affected by serious and chronic diseases from hospitals throughout
728:– Italian Association of Amyotrophic Lateral Sclerosis) participates in the support of the goals of the association, above all in increasing public awareness of the problems connected to
617:, an association supported by the Bill & Melinda Gates Foundation in the development of one of the most efficient antimalaria medicines available, a fixed combination consisting of
1027:
447:)and approved in 2011. The new drug has obtained registration in Cambodia, Ghana, and Tanzania and is started in Burkina Faso, Mozambique, and other key African endemic countries.
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401:, a substance of natural origin, enabled a greater understanding of its efficacy in correcting the biochemical and metabolic defects at the base of numerous other pathologies.
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vitamin complex in
September 1966 – an antiasthenic medicine that soon spread within the field of restorative infantile therapies – Sigma-Tau definitively asserted itself as a
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who promotes the culture of peace and the safeguarding of the rights of children throughout the world, through awareness and information activities;
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Sigma-Tau is the main element of a group in which other companies operate, in accordance with the prospects of the corporate development plan.
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Leadiant
Biosciences has been confronted with ethical disputes amid the +1000% increase (from €0,14 to €140) in the price of one of their
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In 2018 Leadiant
Biosciences came under fire for creating a monopoly for CDCA and unnecessarily increasing the price by a factor of 335.
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emissions that have fallen from 5,932 tons to 5,587 in 2007. Since 2007, Sigma-Tau has begun waste sorting and choosing
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equipped with state-of-the-art automatic production machinery to provide steady employment for 64 people. The choice of
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to develop research, promote scientific and cultural progress, and safeguard the results of scientific investigation.
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Biofutura was founded in 2001 with the objective of developing pharmaceutical products in the cure of diseases of the
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866:"Another Shkreli-like drug price controversy? Leadiant finds itself in the spotlight after 500-fold price hike — FT"
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nature reserve in the Tuscan-Emilian Apennine Mountains. The association works in partnership with the
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in 1984 for its value as a life-saving medicine. The chemical and biologic pharmacology study of
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has developed a new medicine for the treatment of malaria a fixed combination consisting of
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839:"Price Increase in EU Calls Comparisons Between Leadiant Biosciences and Martin Shkreli"
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has for many years supported Destinazione Domani, the popular science journal by AIL,
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Responsible for the clinical development of Sigma-Tau products in the United States.
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and abroad for free, at the Cesto del Lupo oasis – a park located in the
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collaborates with the Italian branch of non-profit organization
913:"Dutch doctors fight pharma company's 500-fold drug price rise"
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439:. The registration dossier was presented on July 3, 2009, in
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Sigma-Tau in collaboration with the non-profit organization
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supports various patients’ associations, including l’AGOP (
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Associazione italiana contro le leucemie-linfomi e mieloma
698:) and at the same time training local healthcare workers.
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Construction began in 1964 of an industrial facility in
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World Centre of Compassion for Children International
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Associazione Italiana Sclerosi Laterale Amiotrofica
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532:Sigma-Tau Research Switzerland - Mendrisio, CH
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1018:Pharmaceutical companies established in 1957
961:: CS1 maint: multiple names: authors list (
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647:, chaired by Nobel prize-winner for peace,
522:Sigma-Tau Research Inc. - Gaithersburg, USA
53:Learn how and when to remove these messages
936:Zafra, Oriol GĂĽell, Mariano (2021-12-09).
708:Associazione Genitori Oncologia Pediatrica
346:Sigma-Tau Industrie Farmaceutiche Riunite,
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234:Learn how and when to remove this message
216:Learn how and when to remove this message
114:Learn how and when to remove this message
580:Pharmaceutical Accountability Foundation
348:was founded in 1957 by research chemist
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770:Association of Hole in the Wall Camps
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753:non-profit diabetes association and
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820:"About Leadiant Biosciences"
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379:From the 1970s to today
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793:Controversy
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688:hepatitis B
627:artemisinin
623:piperaquine
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437:artemisinin
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327:1919 (2013)
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872:20 October
806:References
672:diphtheria
473:products.
369:Rekord B12
295:Key people
176:newspapers
84:improve it
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504:carnitine
399:carnitine
308:Medicines
248:Sigma-Tau
206:July 2013
45:talk page
957:cite web
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788:sector.
696:measles
680:tetanus
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