1471:
1492:
248:
Sulfones, such as dapsone and sulfoxone (Diasone), are well absorbed orally and are widely distributed throughout body fluids and tissues. Peak concentrations of dapsone are reached within 1 to 3 hours of oral administration and have a half-life of 21 to 44 hours; about 50% of administered dapsone is
244:
and are used only in the treatment of leprosy. Dapsone (Avlosulfon) is the most widely used sulfone for the long-term therapy of leprosy. Although the sulfones are highly effective against most strains of M. leprae, a small number of organisms, especially those found in lepromatous leprosy patients,
133:
is characterized by depressed cell-mediated immunity, numerous bacilli within the tissues, no granulomas, and a negative skin test for lepromin. Within these two extremes are the patients with an intermediate or borderline form of leprosy who show a variable lepromin reaction and few bacilli; they
253:. The sulfones tend to remain in the skin, muscle, kidney, and liver up to 3 weeks after therapy is stopped. The concentration in inflamed skin is 10 to 15 times higher than that found in normal skin. The sulfones are retained in the circulation for a long time (12–35 days) because of
105:
cannot be grown on routine laboratory culture media, so drug sensitivity testing in vitro is not possible. Growth and drug susceptibility testing are done by injecting into animal models. One description of a clinical picture that results from
376:. The most disturbing adverse reaction to clofazimine is a red-brown discoloration of the skin, especially in light-skinned persons. A rare but serious adverse reaction is acute abdominal pain significant enough to warrant exploratory
99:. Host defenses are crucial in determining the patient's response to the disease, the clinical presentation, and the bacillary load. These factors also influence the length of therapy and the risk of adverse reactions to medication.
203:
because such a regimen has proven to be more effective, delays the emergence of resistance, prevents relapse, and shortens the duration of therapy. Established agents used in the treatment of leprosy are
288:. Acedapsone is a derivative of dapsone that has little activity against M. leprae but is converted to an active dapsone metabolite. It is a long-acting intramuscular repository form of dapsone with a
245:
are less susceptible and can persist for many years, resulting in relapse. Before the introduction of current multidrug regimens, resistance rates were as high as 20% with dapsone monotherapy.
1423:
503:
353:
DNA binding. Its oral absorption is quite variable, with 9 to 70% of the drug eliminated in the feces. Clofazimine achieves significant concentrations in tissues, including the
2024:
415:
are weakly bacteriocidal against M. leprae and can be used as alternatives to clofazimine in the treatment of MDR leprosy. Both cause GI intolerance and are expensive.
216:. Treatment of tuberculoid leprosy is continued for at least 1 to 2 years, while patients with lepromatous leprosy are generally treated for 5 years. In addition to
1480:
364:
Clofazimine is given to treat sulfone-resistant leprosy or to patients who are intolerant to sulfones. It also exerts an antiinflammatory effect and prevents
2014:
1529:
493:
1274:
471:
368:, which can interrupt treatment with dapsone. This is a major advantage of clofazimine over other antileprosy drugs. Ulcerative lesions caused by
2043:
847:
1611:
1134:
1127:
372:
respond well to clofazimine. It also has some activity against M. tuberculosis and can be used as last resort therapy for the treatment of
1234:
877:
740:
462:
285:
2029:
1507:
373:
311:
1522:
314:
deficiency. Within a few weeks of therapy some patients may develop acute skin lesions described as sulfone syndrome or dapsone
2019:
1030:
486:
397:
277:
729:
511:
2092:
2060:
1714:
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990:
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365:
1796:
458:
446:
2048:
1682:
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1045:
723:
574:
1774:
1671:
1559:
1542:
1082:
837:
369:
111:
57:
349:
dye that has some activity against M. leprae. Its precise mechanism of action is unknown but may involve
1841:
1661:
767:
703:
548:
292:
of 46 days. It may prove useful in leprosy patients who cannot tolerate long-term oral dapsone therapy.
2009:
1687:
842:
822:
691:
358:
95:
163:
1451:
1187:
973:
752:
579:
233:
130:
107:
1491:
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663:
385:
1538:
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686:
629:
619:
442:
389:
303:
2087:
1456:
1279:
1204:
1192:
1117:
983:
862:
651:
307:
199:
Current recommendations for the treatment of leprosy suggest multidrug regimens rather than
273:, is used in the treatment of both multibacillary and paucibacillary M. leprae infections.
1837:
1828:
1496:
1441:
1310:
1305:
1144:
1077:
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745:
636:
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2054:
1979:
1723:
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1224:
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1164:
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1139:
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614:
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331:
250:
241:
192:
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1913:
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1891:
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1751:
1407:
1380:
1239:
1057:
968:
948:
944:
807:
735:
624:
539:
431:
412:
350:
254:
361:
of 70 days. It is primarily excreted in bile, with less than 1% excretion in urine.
1951:
1884:
1875:
1862:
1741:
1700:
1695:
1550:
1365:
1284:
1020:
978:
812:
802:
718:
713:
346:
221:
217:
923:
17:
1973:
1939:
1905:
1895:
1818:
1782:
1639:
1592:
1249:
1159:
899:
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680:
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408:
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342:
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270:
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188:
171:
157:
87:
77:
67:
47:
1991:
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1955:
1845:
1624:
1607:
1582:
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1398:
1356:
1325:
1320:
1259:
1254:
1244:
1182:
1168:
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1011:
931:
927:
868:
828:
783:
779:
669:
605:
555:
520:
516:
377:
327:
315:
266:
258:
237:
213:
167:
82:
72:
42:
1985:
1962:
1934:
1879:
1871:
1764:
1759:
1736:
1644:
1597:
1587:
1568:
1335:
1315:
1289:
1264:
1199:
1177:
1005:
918:
792:
296:
289:
184:
177:
153:
119:
31:
is a drug that interferes with proliferation of the bacterium that causes
1946:
1731:
1629:
1436:
1300:
1296:
1269:
708:
641:
560:
319:
115:
62:
1814:
1619:
1412:
1330:
995:
762:
584:
534:
205:
147:
143:
123:
52:
32:
1634:
1094:
757:
299:
224:
support, rehabilitation, and surgical repair of any disfiguration.
1852:
1394:
1104:
599:
1098:
281:
261:
in the liver, and 70 to 80% of drug is excreted in the urine as
1511:
475:
134:
may progress to either tuberculoid or lepromatous leprosy.
276:
Dapsone is also used in the treatment and prevention of
265:. Dapsone, combined with other antileprosy agents like
432:
Definition: leprostatic from Online
Medical Dictionary
504:
2002:
1926:
1861:
1827:
1804:
1795:
1773:
1750:
1722:
1713:
1681:
1653:
1606:
1567:
1558:
1421:
1393:
1349:
1158:
1093:
1056:
1004:
917:
861:
821:
778:
662:
598:
510:
2025:Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim
93:Leprosy is a chronic infectious disease caused by
284:patients who are allergic to or intolerant of
1523:
487:
38:The following agents are leprostatic agents:
8:
2015:Ethambutol/isoniazid/pyrazinamide/rifampicin
502:Major chemical drug groups – based upon the
1801:
1719:
1564:
1530:
1516:
1508:
494:
480:
472:
445:at the U.S. National Library of Medicine
232:The sulfones are structural analogues of
384:. Other infrequent side effects include
318:. Some rare side effects include fever,
424:
1481:Pharmacological classification systems
848:Selective estrogen receptor modulators
1128:Non-steroidal anti-inflammatory drugs
257:drug recirculation. The sulfones are
122:formation, and a relative paucity of
7:
741:Angiotensin II receptor antagonists
236:and are competitive inhibitors of
25:
2030:Rifampicin/isoniazid/pyrazinamide
312:glucose-6-phosphate dehydrogenase
1490:
1470:
1469:
2020:Ethambutol/isoniazid/rifampicin
878:Hypothalamic–pituitary hormones
278:Pneumocystis carinii pneumonia
1:
630:Thrombolytics / fibrinolytics
404:Ethionamide and Prothionamide
295:The sulfones can produce non-
286:trimethoprim–sulfamethoxazole
220:, patients with leprosy need
1341:Wakefulness-promoting agents
1914:Thioacetazone (amithiozone)
1715:Protein synthesis inhibitor
138:Kinds of antileprotic drugs
110:is characterized by intact
2109:
991:Intravenous immunoglobulin
2038:
1465:
366:erythema nodosum leprosum
1797:Cell envelope antibiotic
1683:Topoisomerase inhibitors
1046:Topoisomerase inhibitors
730:renin–angiotensin system
724:Calcium channel blockers
447:Medical Subject Headings
240:synthesis. Sulfones are
1775:Polypeptide antibiotics
1667:Calcium aminosalicylate
1672:Sodium aminosalicylate
1560:Nucleic acid inhibitor
1543:tuberculosis treatment
838:Hormonal contraception
768:Bile acid sequestrants
549:Proton-pump inhibitors
512:gastrointestinal tract
370:Mycobacterium ulcerans
306:, and sometimes acute
129:At the other extreme,
112:cell-mediated immunity
58:desoxyfructo-serotonin
1842:arabinosyltransferase
1662:4-Aminosalicylic acid
2010:Ethambutol/isoniazid
1447:Radiopharmaceuticals
1235:Antiparkinson agents
228:Dapsone and Sulfones
183:Other antibiotics -
96:Mycobacterium leprae
1878:synth. inhibition:
1230:Antimigraine agents
1220:Antidementia agents
1123:Anti-inflammatories
813:Medicated dressings
753:Antihyperlipidemics
580:Diabetes medication
459:MeSH list of agents
131:lepromatous leprosy
108:tuberculoid leprosy
2093:Antileprotic drugs
2065:Never to phase III
1547:leprostatic agents
1539:Antimycobacterials
1083:Immunosuppressants
953:Antimycobacterials
909:Antithyroid agents
893:Mineralocorticoids
697:Cardiac stimulants
687:Cardiac glycosides
679:cardiac therapy /
575:Anti-obesity drugs
443:Leprostatic+agents
386:splenic infarction
310:in persons with a
18:Leprostatic agents
2075:
2074:
1922:
1921:
1912:Others/unsorted:
1791:
1790:
1709:
1708:
1505:
1504:
1408:Ophthalmologicals
1118:Anabolic steroids
1021:Anticancer agents
984:Ectoparasiticides
704:Antihypertensives
652:Antifibrinolytics
398:upper GI bleeding
390:bowel obstruction
304:methemoglobinemia
29:leprostatic agent
16:(Redirected from
2100:
1802:
1720:
1565:
1532:
1525:
1518:
1509:
1494:
1473:
1472:
1457:Senotherapeutics
1311:Neuroprotectives
1306:Mood stabilizers
1205:Anti-ADHD agents
1145:Muscle relaxants
1078:Immunostimulants
1073:Immunomodulators
905:Thyroid hormones
843:Fertility agents
746:Renin inhibitors
637:Antihemorrhagics
604:forming organs (
590:Dietary minerals
496:
489:
482:
473:
466:
456:
450:
440:
434:
429:
374:MDR tuberculosis
359:plasma half-life
355:phagocytic cells
308:hemolytic anemia
21:
2108:
2107:
2103:
2102:
2101:
2099:
2098:
2097:
2078:
2077:
2076:
2071:
2070:
2055:Clinical trials
2034:
1998:
1918:
1857:
1838:Ethylenediamine
1829:Arabinogalactan
1823:
1787:
1769:
1746:
1724:Aminoglycosides
1705:
1686:
1677:
1649:
1602:
1572:
1554:
1536:
1506:
1501:
1497:Medicine portal
1461:
1417:
1389:
1384:
1376:Cough medicines
1371:Bronchodilators
1352:
1345:
1225:Antidepressants
1215:Anticonvulsants
1163:
1154:
1150:Bisphosphonates
1140:Corticosteroids
1102:
1089:
1061:
1052:
1036:Spindle poisons
1026:Antimetabolites
1009:
1000:
922:
913:
888:Glucocorticoids
883:Corticosteroids
864:
857:
824:
817:
774:
692:Antiarrhythmics
665:
658:
615:Antithrombotics
603:
594:
570:Antipropulsives
566:Antidiarrhoeals
543:
514:
506:
500:
470:
469:
457:
453:
441:
437:
430:
426:
421:
406:
394:paralytic ileus
340:
230:
140:
118:skin reaction,
23:
22:
15:
12:
11:
5:
2106:
2104:
2096:
2095:
2090:
2080:
2079:
2073:
2072:
2069:
2068:
2067:
2066:
2063:
2052:
2046:
2040:
2039:
2036:
2035:
2033:
2032:
2027:
2022:
2017:
2012:
2006:
2004:
2000:
1999:
1997:
1996:
1980:Nitroimidazole
1976:
1971:
1959:
1943:
1930:
1928:
1924:
1923:
1920:
1919:
1917:
1916:
1909:
1908:
1903:
1898:
1892:Thiocarbamides
1888:
1887:
1882:
1868:
1866:
1859:
1858:
1856:
1855:
1849:
1848:
1834:
1832:
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1811:
1809:
1799:
1793:
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1768:
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1657:
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1642:
1637:
1632:
1627:
1622:
1616:
1614:
1604:
1603:
1601:
1600:
1595:
1590:
1585:
1579:
1577:
1574:RNA polymerase
1562:
1556:
1555:
1537:
1535:
1534:
1527:
1520:
1512:
1503:
1502:
1500:
1499:
1488:
1483:
1478:
1466:
1463:
1462:
1460:
1459:
1454:
1449:
1444:
1442:Contrast media
1439:
1433:
1431:
1419:
1418:
1416:
1415:
1410:
1404:
1402:
1395:sensory organs
1391:
1390:
1388:
1387:
1382:
1378:
1373:
1368:
1362:
1360:
1347:
1346:
1344:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1294:
1293:
1292:
1287:
1282:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1240:Antipsychotics
1237:
1232:
1227:
1222:
1217:
1212:
1210:Antiaddictives
1207:
1202:
1197:
1196:
1195:
1190:
1180:
1174:
1172:
1165:nervous system
1156:
1155:
1153:
1152:
1147:
1142:
1137:
1135:Antirheumatics
1132:
1131:
1130:
1120:
1114:
1112:
1091:
1090:
1088:
1087:
1086:
1085:
1080:
1069:
1067:
1054:
1053:
1051:
1050:
1049:
1048:
1043:
1041:Antineoplastic
1038:
1033:
1028:
1017:
1015:
1002:
1001:
999:
998:
993:
988:
987:
986:
981:
976:
974:Antiprotozoals
969:Antiparasitics
966:
961:
956:
949:Antibacterials
945:Antimicrobials
941:
939:
915:
914:
912:
911:
902:
897:
896:
895:
890:
880:
874:
872:
859:
858:
856:
855:
850:
845:
840:
834:
832:
819:
818:
816:
815:
810:
808:Antipsoriatics
805:
800:
795:
789:
787:
776:
775:
773:
772:
771:
770:
765:
760:
750:
749:
748:
743:
738:
736:ACE inhibitors
726:
721:
716:
711:
706:
701:
700:
699:
694:
689:
675:
673:
664:cardiovascular
660:
659:
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649:
644:
634:
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632:
627:
625:Anticoagulants
622:
611:
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587:
582:
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563:
558:
553:
552:
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546:
541:
537:
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524:
508:
507:
501:
499:
498:
491:
484:
476:
468:
467:
451:
435:
423:
422:
420:
417:
405:
402:
339:
336:
332:hepatotoxicity
251:serum proteins
242:bacteriostatic
229:
226:
197:
196:
193:Clarithromycin
181:
175:
164:Antitubercular
161:
151:
139:
136:
91:
90:
85:
80:
75:
70:
65:
60:
55:
50:
45:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2105:
2094:
2091:
2089:
2086:
2085:
2083:
2064:
2062:
2059:
2058:
2056:
2053:
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2047:
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2042:
2041:
2037:
2031:
2028:
2026:
2023:
2021:
2018:
2016:
2013:
2011:
2008:
2007:
2005:
2001:
1994:
1993:
1988:
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1982:
1981:
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1969:
1965:
1964:
1960:
1957:
1953:
1949:
1948:
1944:
1941:
1937:
1936:
1932:
1931:
1929:
1927:Other/unknown
1925:
1915:
1911:
1910:
1907:
1904:
1902:
1901:Prothionamide
1899:
1897:
1893:
1890:
1889:
1886:
1883:
1881:
1877:
1873:
1870:
1869:
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1836:
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1826:
1820:
1816:
1813:
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1810:
1807:
1806:Peptidoglycan
1803:
1800:
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1794:
1784:
1781:
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1778:
1776:
1772:
1766:
1763:
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1578:
1575:
1570:
1566:
1563:
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1557:
1552:
1548:
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1533:
1528:
1526:
1521:
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1514:
1513:
1510:
1498:
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1489:
1487:
1484:
1482:
1479:
1477:
1468:
1467:
1464:
1458:
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1440:
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1435:
1434:
1432:
1429:
1425:
1420:
1414:
1411:
1409:
1406:
1405:
1403:
1400:
1396:
1392:
1386:
1379:
1377:
1374:
1372:
1369:
1367:
1366:Decongestants
1364:
1363:
1361:
1358:
1354:
1348:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1298:
1295:
1291:
1288:
1286:
1285:Dissociatives
1283:
1281:
1278:
1277:
1276:
1275:Hallucinogens
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1206:
1203:
1201:
1198:
1194:
1191:
1189:
1186:
1185:
1184:
1181:
1179:
1176:
1175:
1173:
1170:
1166:
1161:
1157:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1129:
1126:
1125:
1124:
1121:
1119:
1116:
1115:
1113:
1110:
1106:
1100:
1096:
1092:
1084:
1081:
1079:
1076:
1075:
1074:
1071:
1070:
1068:
1065:
1059:
1055:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1023:
1022:
1019:
1018:
1016:
1013:
1007:
1003:
997:
994:
992:
989:
985:
982:
980:
979:Anthelmintics
977:
975:
972:
971:
970:
967:
965:
962:
960:
957:
954:
950:
946:
943:
942:
940:
937:
933:
929:
925:
920:
916:
910:
906:
903:
901:
898:
894:
891:
889:
886:
885:
884:
881:
879:
876:
875:
873:
870:
866:
860:
854:
851:
849:
846:
844:
841:
839:
836:
835:
833:
830:
826:
823:genitourinary
820:
814:
811:
809:
806:
804:
803:Antipruritics
801:
799:
796:
794:
791:
790:
788:
785:
781:
777:
769:
766:
764:
761:
759:
756:
755:
754:
751:
747:
744:
742:
739:
737:
734:
733:
732:
731:
727:
725:
722:
720:
719:Beta blockers
717:
715:
712:
710:
707:
705:
702:
698:
695:
693:
690:
688:
685:
684:
683:
682:
677:
676:
674:
671:
667:
661:
653:
650:
648:
645:
643:
640:
639:
638:
635:
631:
628:
626:
623:
621:
620:Antiplatelets
618:
617:
616:
613:
612:
610:
607:
601:
597:
591:
588:
586:
583:
581:
578:
576:
573:
571:
567:
564:
562:
559:
557:
554:
550:
547:
545:
538:
536:
533:
532:
531:
528:
527:
525:
522:
518:
513:
509:
505:
497:
492:
490:
485:
483:
478:
477:
474:
465:
464:
460:
455:
452:
448:
444:
439:
436:
433:
428:
425:
418:
416:
414:
413:prothionamide
410:
403:
401:
399:
395:
391:
387:
383:
379:
375:
371:
367:
362:
360:
356:
352:
351:mycobacterial
348:
344:
337:
335:
333:
329:
326:, reversible
325:
321:
317:
313:
309:
305:
301:
298:
293:
291:
287:
283:
279:
274:
272:
268:
264:
260:
256:
255:hepatobiliary
252:
246:
243:
239:
235:
227:
225:
223:
219:
215:
211:
207:
202:
194:
190:
186:
182:
179:
176:
173:
169:
165:
162:
159:
156:derivative -
155:
152:
149:
145:
142:
141:
137:
135:
132:
127:
125:
121:
117:
114:, a positive
113:
109:
104:
100:
98:
97:
89:
86:
84:
81:
79:
76:
74:
71:
69:
66:
64:
61:
59:
56:
54:
51:
49:
46:
44:
41:
40:
39:
36:
34:
30:
19:
2003:Combinations
1990:
1984:
1978:
1961:
1952:Pyrazinamide
1945:
1933:
1885:Methaniazide
1876:mycolic acid
1863:Mycolic acid
1742:Streptomycin
1701:Moxifloxacin
1696:Gatifloxacin
1660:
1546:
1541:, including
1280:Psychedelics
1250:Aphrodisiacs
924:infestations
900:Sex hormones
853:Sex hormones
798:Cicatrizants
728:
714:Vasodilators
681:antianginals
678:
530:stomach acid
529:
461:
454:
438:
427:
407:
363:
347:bactericidal
345:is a weakly
341:
294:
275:
247:
231:
222:psychosocial
218:chemotherapy
198:
128:
102:
101:
94:
92:
37:
28:
26:
2051:from market
1974:Bedaquiline
1940:Clofazimine
1906:Thiocarlide
1896:Ethionamide
1844:inhibitor:
1819:Cycloserine
1783:Capreomycin
1752:Oxazolidone
1640:Solasulfone
1608:Antifolates
1593:Rifapentine
1413:Otologicals
1385:antagonists
1351:respiratory
1326:Orexigenics
1321:Neurotoxins
1270:Euphoriants
1260:Entactogens
1255:Depressants
1245:Anxiolytics
1183:Anesthetics
959:Antifungals
556:Antiemetics
544:antagonists
409:Ethionamide
382:laparoscopy
357:; it has a
343:Clofazimine
338:Clofazimine
324:paresthesia
271:clofazimine
263:metabolites
210:clofazimine
201:monotherapy
189:Minocycline
172:Ethionamide
158:Clofazimine
88:thalidomide
78:rifapentine
68:ethionamide
48:clofazimine
2082:Categories
1992:Pretomanid
1968:Terizidone
1956:Morinamide
1872:Hydrazides
1846:Ethambutol
1817:analogue:
1688:quinolones
1625:Acedapsone
1583:Rifampicin
1569:Rifamycins
1336:Stimulants
1316:Nootropics
1290:Deliriants
1265:Entheogens
1200:Anorectics
1178:Analgesics
1031:Alkylating
964:Antivirals
919:infections
793:Emollients
647:Coagulants
517:metabolism
419:References
378:laparotomy
328:neuropathy
316:dermatitis
267:rifampicin
259:acetylated
238:folic acid
214:rifampicin
168:Rifampicin
83:sulfameter
73:rifampicin
43:acedapsone
2061:Phase III
2049:Withdrawn
1986:Delamanid
1963:Isoxazole
1935:Phenazine
1880:Isoniazid
1765:Sutezolid
1760:Linezolid
1737:Kanamycin
1645:Sulfoxone
1598:Rifalazil
1588:Rifabutin
1576:inhibitor
1486:ATC codes
1452:Dressings
1437:Antidotes
1301:Sedatives
1297:Hypnotics
1006:malignant
863:endocrine
709:Diuretics
642:Platelets
602:and blood
561:Laxatives
297:hemolytic
290:half-life
249:bound to
185:Ofloxacin
178:Solapsone
154:Phenazine
120:granuloma
103:M. leprae
1947:Pyrazine
1732:Amikacin
1630:Diucifon
1331:Serenics
996:Vaccines
763:Fibrates
585:Vitamins
535:Antacids
463:82007917
320:pruritus
166:drugs -
116:lepromin
63:diucifon
2088:Leprosy
1815:Alanine
1620:Dapsone
1188:General
1095:muscles
1064:L03–L04
1060:disease
1012:L01–L02
1008:disease
758:Statins
206:dapsone
148:Dapsone
144:Sulfone
124:bacilli
53:dapsone
33:leprosy
2044:WHO-EM
1635:Promin
1495:
1474:
1422:other
1353:system
1105:joints
1058:immune
865:system
825:system
666:system
449:(MeSH)
396:, and
330:, and
300:anemia
212:, and
150:(DDS),
1865:layer
1853:SQ109
1831:layer
1808:layer
1476:Drugs
1193:Local
1160:brain
1099:bones
600:blood
1545:and
1103:and
780:skin
411:and
282:AIDS
269:and
234:PABA
1654:ASA
1612:DSI
1551:J04
1424:ATC
1162:and
921:and
380:or
280:in
2084::
2057::
1989:,
1954:,
1894::
1299:/
1097:,
947::
936:QI
934:,
930:,
907:/
568:/
515:/
400:.
392:,
388:,
334:.
322:,
302:,
208:,
191:,
187:,
170:,
146:-
126:.
35:.
27:A
1995:)
1983:(
1970:)
1966:(
1958:)
1950:(
1942:)
1938:(
1874:/
1840:/
1685:/
1674:)
1665:(
1610:/
1571:/
1553:)
1549:(
1531:e
1524:t
1517:v
1430:)
1428:V
1426:(
1401:)
1399:S
1397:(
1383:1
1381:H
1359:)
1357:R
1355:(
1171:)
1169:N
1167:(
1111:)
1109:M
1107:(
1101:,
1066:)
1062:(
1014:)
1010:(
955:)
951:(
938:)
932:P
928:J
926:(
871:)
869:H
867:(
831:)
829:G
827:(
786:)
784:D
782:(
672:)
670:C
668:(
608:)
606:B
542:2
540:H
523:)
521:A
519:(
495:e
488:t
481:v
195:,
180:,
174:,
160:,
20:)
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