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Lorna Casselton

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binding to DNA. These trigger sexual development by the association of A proteins with different homeodomains sequences (HD1 and HD2). A factors contain several duplicate genes coding for the A protein but it is only necessary for any one of these genes to be allelic unmatched to trigger the whole
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ending in sexual reproduction are all controlled by a positive stimulus triggered by the meeting of unlike alleles of the A and B factors. This is in contrast to the oppositional inhibition of the final stages of sexual reproduction by the meeting of like alleles in flowering plants. Using elegant
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Casselton was a Fellow of St Cross College Oxford from 1993 to 2003, and was appointed Professor of Fungal Genetics at Oxford in 1997. Her specialism was sexual development in fungi and she contributed to over 100 publications on this topic. She was a Fellow of
1461: 1541: 1545: 1465: 1964: 1929: 336: 332: 351:, from 2000. She was a member of the Royal Society's Council from 2002 to 2003, and rejoined the Council in 2006 as Vice-President and Foreign Secretary, replacing Professor Dame 1904: 1594: 1029: 815:"The combination of dissimilar alleles of the A-alpha and A-beta gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom 264: 1909: 1899: 1066: 1954: 1944: 1914: 378:
She married Peter John Casselton in 1961, divorcing him in 1978. She married William Joseph Dennis Tollett in 1981. She died after a short illness, aged 75.
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found in mammalian cells suggest that helical regions adjacent to the homeodomain may discriminate between compatible and incompatible protein associations.
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and her father's interest in natural history and genetics encouraged her and her sister Pauline in the direction of biology. She was educated at
328: 747:"An N-terminal dimerization domain permits homeodomain proteins to choose compatible partners and initiate sexual development in the mushroom 1959: 1949: 1974: 1483: 1316: 491:"Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)" 1939: 1577: 1924: 363: 324: 181: 1816: 1732: 300: 1969: 348: 1934: 1794: 1404: 197: 1508: 1919: 1784: 1586: 403: 311:, from which she gained a Bachelor of Science (BSc) degree in botany and a Doctor of Philosophy (PhD) degree in 1964. 251: 247: 152: 140: 33: 29: 899:
Sealy-Lewis, HM.; Casselton, LA. (1978). "Restoration of enzyme activity by recessive missense suppressors in fungus
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Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press
1757: 399: 308: 102: 1705: 344: 661:"A constitutively active G-protein-coupled receptor causes mating self-compatibility in the mushroom Coprinus" 630:
Brown, AJ; Casselton, LA. (2001). "Mating in mushrooms: increasing the chances but prolonging the affair".
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for services to fungal genetics and international science. Her nomination for the Royal Society reads:
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Kues, U.; Casselton, LA. (1992). "Fungal mating type genes - regulators of sexual development".
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Riquelme, Meritxell; Challen, Michael P.; Casselton, Lorna A.; Brown, Andrew J. (6 May 2005).
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Shahriari, H.; Casselton, L. A. (1974). "Suppression of methionine mutants in Coprinus".
1842: 1779: 1752: 1717: 1690: 1680: 1675: 1650: 1628: 873: 685: 660: 578: 543: 525: 490: 304: 882: 853: 805: 775: 746: 643: 1878: 1857: 1852: 1742: 1670: 1665: 1590: 1171: 1140: 1115: 728: 703: 387: 352: 1444: 1050: 1863: 1837: 1821: 1806: 1747: 1685: 1660: 1623: 1360: 1231:"Missense suppression in Coprinus lagopus associated with a chromosome duplication" 932: 442: 296: 295:, Essex to William Charles Henry Smith and Cecile Smith (nÊe Bowman). Her parents' 1321: 1167: 1131: 719: 319:
Casselton began her career in lecturing and research as an assistant lecturer at
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Stajich, J. E.; Wilke, S. K.; Ahren, D.; Au, C. H.; et al. (14 June 2010).
455: 370:, travelling to 27 different countries during three and a half years in office. 255:(18 July 1938 – 14 February 2014) was a British academic and biologist. She was 1542:"EC/1999/07: Casselton, Lorna Ann. Royal Society Library and Archive Catalogue" 676: 1291: 1274: 1202: 1185: 993: 972: 962: 941: 1247: 1230: 569: 516: 1700: 1695: 1341:
Lorna Casselton obituary: Researcher into the genetic basis of fungal mating
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The British Mycological Society awarded her an Honorary Membership in 2002.
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genetic and molecular techniques with different genetic stocks including
446: 423: 292: 260: 71: 924: 835: 814: 766: 1436: 916: 271:, and was known for her genetic and molecular analysis of the mushroom 1406:
The production, behaviour and genetics of diploids of Coprinus lagopus
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The production, behaviour and genetics of diploids of Coprinus lagopus
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Binninger, DM.; Skrzynia, C.; Pukkila, PJ.; Casselton, LA. (1987).
438: 367: 1116:"Molecular genetics of mating recognition in basidiomycete fungi" 704:"Molecular genetics of mating recognition in basidiomycete fungi" 544:"The Origin of MultipleBMating Specificities inCoprinus cinereus" 659:
Olesnicky, NS.; Brown, AJ.; Dowell, SJ.; Casselton, LA. (1999).
1559: 1186:"The production and behaviour of diploids of Coprinus lagopus" 358:
As Foreign Secretary of the Royal Society, Casselton gave the
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by Queen Mary College, University of London in 2009 and
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Megan Palmer, 18 February 2014. Retrieved 23 June 2015.
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Banham, AH.; Asanteowusu, RN.; Casselton, LA. (1995).
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which she used to demonstrate for the first time that
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Biographical Memoirs of Fellows of the Royal Society
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sexual development. Other domains characteristic of
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Archived from 1336: 1334: 1332: 1330: 327:from 1989 to 1991 and was later awarded an 112:Genetic and molecular analysis of mushrooms 1578: 1564: 1556: 1312: 1310: 1120:Microbiology and Molecular Biology Reviews 708:Microbiology and Molecular Biology Reviews 42: 20: 1456: 1454: 1290: 1246: 1201: 1139: 1085: 1083: 1081: 1079: 992: 973:"Production and behaviour of diploids of 961: 881: 834: 774: 727: 684: 612: 577: 559: 524: 506: 16:British geneticist, academic and educator 1409:(PhD thesis). University College London. 1364:, 31 March 2014. Retrieved 23 June 2015. 1016: 702:Casselton, LA.; Olesnicky, NS. (1998). 458:, she has shown that the A factor is a 429:, in particular of the incompatibility 335:Postdoctoral Fellowship, followed by a 126:William Joseph Dennis Tollett (m. 1981) 1530:(Supplement). 16 June 2012. p. 7. 291:Casselton was born on 18 July 1938 in 1910:Academics of the University of Oxford 1900:20th-century British women scientists 402:in September 2010. She was appointed 394:in 2008, and was awarded an Honorary 7: 1425:MGG Molecular & General Genetics 1163: 1161: 1159: 390:in 1999. She became a Member of the 339:Senior Research Fellowship in 1995. 1955:Female fellows of the Royal Society 1945:Fellows of St Cross College, Oxford 1915:Alumni of University College London 307:in Southend-on-Sea. She studied at 940:Casselton, LA.; Lewis, D. (1967). 874:10.1002/j.1460-2075.1987.tb04828.x 14: 1064:Professor Lorna Casselton CBE FRS 386:She was elected a Fellow of the 360:Royal Society Rutherford Lecture 1895:20th-century British biologists 1235:Journal of General Microbiology 325:Queen Mary University of London 182:Queen Mary University of London 123:Peter John Casselton (d. 1978); 905:Molecular and General Genetics 301:Southend High School for Girls 1: 1170:Casselton's biography on the 806:10.1016/s0953-7562(09)80107-x 644:10.1016/s0168-9525(01)02343-5 466:genes encoding proteins with 1960:Members of Academia Europaea 1950:Fellows of the Royal Society 1132:10.1128/mmbr.62.1.55-70.1998 720:10.1128/mmbr.62.1.55-70.1998 1975:People from Southend-on-Sea 1484:"Honorary Graduates of UCL" 1375:"Professor Lorna Casselton" 1114:; Olesnicky, N. S. (1998). 1073:, University College London 597:"Mate recognition in fungi" 561:10.1534/genetics.105.040774 265:Department of Plant Science 1996: 349:St Hilda's College, Oxford 1940:British women geneticists 1292:10.1017/s0016672300009915 1203:10.1017/S0016672300004080 1184:Casselton, L. A. (2009). 994:10.1017/s0016672300004080 963:10.1017/s0016672300010314 400:University College London 309:University College London 218: 162: 103:University College London 41: 1925:British women biologists 1801:Graham Barry Warren 1509:St Cross College, Oxford 1357:Lorna Casselton obituary 1248:10.1099/00221287-88-1-20 677:10.1093/emboj/18.10.2756 362:in South Africa and the 345:St Cross College, Oxford 1412:(subscription required) 1100:(subscription required) 971:Casselton, LA. (1965). 823:Genes & Development 595:Casselton, LA. (2002). 508:10.1073/pnas.1003391107 1817:Robert Williamson 1812:Peter M. Williams 1733:John G. McWhirter 1043:10.1098/rsbm.2011.0023 614:10.1038/sj.hdy.6800035 477: 414:Distinguished for her 321:Royal Holloway College 1758:John G. Shepherd 1645:John Brian Clegg 483:Selected publications 473:transcription factors 445:, the formation of a 408:2012 Birthday Honours 1970:People from Rochford 1774:Alfred G. Sykes 1712:John Paul Maier 1706:Peter L. Knight 1273:; Lewis, D. (1966). 1069:5 March 2016 at the 794:Mycological Research 433:, A and B. She made 269:University of Oxford 177:University of Oxford 1935:English geneticists 1848:G. Ledyard Stebbins 1785:John F. Toland 1768:James Stirling 1634:Ian Carmichael 1317:Casselton's profile 836:10.1101/gad.6.4.568 767:10.1105/tpc.7.6.773 501:(26): 11889–11894. 431:mating type factors 243:Lorna Ann Casselton 1920:British biologists 1671:Athene Donald 1527:The London Gazette 1437:10.1007/BF00332815 1279:Genetical Research 1190:Genetical Research 981:Genetical Research 950:Genetical Research 917:10.1007/bf00267386 632:Trends in Genetics 420:molecular analysis 382:Awards and honours 257:Professor Emeritus 48:Casselton in 2010. 1980:People from Essex 1872: 1871: 1838:Robert Huber 1822:Magdi Yacoub 1490:on 12 August 2016 856:Coprinus cinereus 817:Coprinus cinereus 749:Coprinus cinereus 671:(10): 2756–2763. 443:nuclear migration 427:Coprinus cinereus 396:Doctor of Science 392:Academia Europaea 274:Coprinus cinereus 240: 239: 164:Scientific career 1987: 1795:Alan Walker 1728:Ernest McCulloch 1723:Iain Mattaj 1609:Frances Ashcroft 1580: 1573: 1566: 1557: 1550: 1549: 1548:on 2 April 2014. 1538: 1532: 1531: 1518: 1512: 1506: 1500: 1499: 1497: 1495: 1479: 1470: 1469: 1468:on 1 March 2012. 1464:. Archived from 1458: 1449: 1448: 1420: 1414: 1413: 1410: 1401:Casselton, Lorna 1397: 1391: 1390: 1388: 1386: 1371: 1365: 1354: 1348: 1338: 1325: 1314: 1305: 1304: 1294: 1271:Casselton, L. A. 1267: 1261: 1260: 1250: 1227:Casselton, L. A. 1222: 1216: 1215: 1205: 1181: 1175: 1165: 1154: 1153: 1143: 1112:Casselton, L. A. 1108: 1102: 1101: 1098: 1087: 1074: 1061: 1055: 1054: 1025:Casselton, L. A. 1021: 1006: 996: 975:Coprinus lagopus 967: 965: 944:Coprinus lagopus 936: 895: 885: 848: 838: 809: 800:(12): 993–1006. 788: 778: 741: 731: 698: 688: 655: 626: 616: 591: 581: 563: 538: 528: 510: 280:Coprinus lagopus 254: 236: 234:/lorna-casselton 233: 231: 229: 210:Doctoral advisor 204: 86: 83:14 February 2014 74:, Essex, England 67: 65: 46: 36: 21: 1995: 1994: 1990: 1989: 1988: 1986: 1985: 1984: 1875: 1874: 1873: 1868: 1826: 1639:Lorna Casselton 1619:Rosa Beddington 1614:Anthony Barrett 1597: 1584: 1554: 1553: 1540: 1539: 1535: 1520: 1519: 1515: 1507: 1503: 1493: 1491: 1481: 1480: 1473: 1460: 1459: 1452: 1422: 1421: 1417: 1411: 1399: 1398: 1394: 1384: 1382: 1381:. 27 March 2014 1373: 1372: 1368: 1355: 1351: 1347:, 31 March 2014 1339: 1328: 1315: 1308: 1269: 1268: 1264: 1224: 1223: 1219: 1183: 1182: 1178: 1166: 1157: 1110: 1109: 1105: 1099: 1089: 1088: 1077: 1071:Wayback Machine 1062: 1058: 1023: 1022: 1018: 1013: 970: 939: 898: 851: 812: 791: 744: 701: 658: 629: 594: 541: 488: 485: 384: 376: 317: 315:Academic career 289: 246: 226: 202: 186: 158: 129: 99:Alma mater 94: 88: 84: 75: 69: 63: 61: 60: 59: 58:Lorna Ann Smith 49: 37: 28: 26: 25:Lorna Casselton 17: 12: 11: 5: 1993: 1991: 1983: 1982: 1977: 1972: 1967: 1962: 1957: 1952: 1947: 1942: 1937: 1932: 1927: 1922: 1917: 1912: 1907: 1902: 1897: 1892: 1887: 1877: 1876: 1870: 1869: 1867: 1866: 1861: 1855: 1850: 1845: 1843:Marc Kirschner 1840: 1834: 1832: 1828: 1827: 1825: 1824: 1819: 1814: 1809: 1804: 1797: 1792: 1787: 1782: 1780:Janet Thornton 1777: 1770: 1765: 1760: 1755: 1753:Dolph Schluter 1750: 1745: 1740: 1735: 1730: 1725: 1720: 1718:Barry Marshall 1715: 1708: 1703: 1698: 1693: 1691:Timothy Gowers 1688: 1683: 1681:Douglas Fearon 1678: 1676:Philip England 1673: 1668: 1663: 1658: 1653: 1651:David Cockayne 1648: 1641: 1636: 1631: 1629:Simon Campbell 1626: 1621: 1616: 1611: 1605: 1603: 1599: 1598: 1585: 1583: 1582: 1575: 1568: 1560: 1552: 1551: 1533: 1513: 1501: 1471: 1450: 1415: 1392: 1366: 1349: 1326: 1306: 1262: 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Index

CBE
FRS

Rochford
Oxford
University College London
CBE
MAE
FRS
University of Oxford
Queen Mary University of London
Thesis
The production, behaviour and genetics of diploids of Coprinus lagopus
Doctoral advisor
royalsociety.org/people/lorna-casselton
CBE
FRS
Professor Emeritus
Genetics
Department of Plant Science
University of Oxford
Coprinus cinereus
Coprinus lagopus
Rochford
smallholding
Southend High School for Girls
grammar school
University College London
Royal Holloway College
Queen Mary University of London

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