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409:. However, her work has demonstrated that patients who achieve a positive acute antidepressant response to 10 weeks of antidepressant treatment adjunctive to a mood stabilizer will probably maintain response with the same continued treatment with risk of manic episode no higher than the reported rate for patients on mood stabilizer monotherapy.
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also provided a series of grants. She has received both support to advance her career, recognizing her leadership in psychiatry, as well as large randomized controlled trials and basic neuroscience grants to advance our understanding of how brain functioning differs between persons with a psychiatric
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addresses and lectures and her research has been presented in 175 posters and abstracts at national and international meetings. More than 15 of her published articles reviewed a specific scientific issue, providing new insights and analyses to the psychiatric clinical or research community. She has
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As
Director of the UCLA Mood Disorder Research Program, Altshuler created a collaborative clinical research infrastructure within the Department of Psychiatry that would span both the UCLA and the Veterans Administration, Brentwood sites. The Mood Disorders Research Program focuses primarily on the
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compared with women who maintained their medication (26%). This study dispelled the myth that pregnancy was protective against depression and, more importantly, provided an evidence-based foundation for women and their physicians to weigh the risks and benefits of continuing versus discontinuing
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She has also devoted her career to focusing on how these disorders are best managed among women in different phases of their life. In particular, she has studied non-depressed women (who have previously had at least one episode of unipolar depression), following them during pregnancy and the
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etiology and treatment of bipolar disorder and major depression. The Women's
Research Program is an adjunct to the Mood Disorders Research Program that has attracted national attention with its focus on depression during phases of life specific to women.
477:. She has cultivated the careers of both fellows and junior faculty who have published productively, received academic appointments and created research programs at prestigious universities and received federal funding under her mentorship.
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disorders. She has conducted several multi-site collaborative studies evaluating the optimal medication and treatment strategies for persons with bipolar disorder. For example, most psychiatrists withdraw treatment with
369:/receptor level and has identified the specificity of abnormal brain functioning for a given psychiatric disorder and phase of illness. For example, she was the first to identify that the
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Director of Mood
Disorders Research, Mental Health Clinic Veterans Administration Medical Center (West Los Angeles) and the UCLA Mood Disorders Clinic, 1995–2015
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These findings regarding basic brain functioning complement her clinically-focused research which has improved the quality of care for persons with
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and led to her fellowship in
Washington D.C. At the NIMH intramural laboratories, she continued this work, completing several projects related to
461:, Solvay). These awards supported not only her own research, but allowed her to train the next generation of psychiatrists in clinical research.
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society. From 1982–1983 she interned at UCLA's Center for Health
Sciences/Wadsworth Veterans Administration. She completed her residency at the
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Julia S. Gouw
Professor of Psychiatry Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Hospital, 1999–2015
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projects while in training with mentors Arnold
Scheibel, M.D. and Jeffrey Cummings, M.D. These foreshadowed her interests in
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Chief, Bipolar
Disorders Clinic, Mental Health Clinic, Veterans Administration Medical Center (West Los Angeles), 1991–2009
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72:
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510:). In addition, she has published more than 27 letters to respond and comment on cutting-edge research by others.
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Outstanding
Research Mentor Award and Outstanding Teacher during multiple years, UCLA Department of Psychiatry
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218:(UCLA) Department of Psychiatry and Biobehavioral Sciences and held the Julia S. Gouw Endowed Chair for
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for more than 25 years. She has consistently played a major leadership role in the research, teaching/
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Director, Outpatient
Research, Mental Health Clinic, VA Medical Center - West Los Angeles 1991–1995
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In addition to NIH funding, she has received a series of grants from private foundations (e.g.,
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in 1986. Altshuler completed a two-year fellowship at the Biological Psychiatry Branch of the
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Gerald L. Klerman Young Investigator Award, National Depressive, Manic-Depressive Association
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Southern California Psychiatric Society Award for Outstanding Achievement in Mood Disorders
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In 1989, Altshuler joined the UCLA Department of Psychiatry faculty, where she has been a
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during her fellowship in biological psychiatry at NIMH. There, she was a pioneer in using
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Altshuler has mentored approximately 8-12 people per year, from new graduates to junior
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Director of Research, Women's Life Center, UCLA Neuropsychiatric Hospital, 1995–2010
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NARSAD's Falcone Prize for Outstanding Achievement in Affective Disorders Research
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and mood disorders. She cemented her clinical interest to study patients with
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Judith Silver Young Scientist Award, National Association of the Mentally Ill
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389:, a trait-like reaction. These findings differentiate bipolar disorder from
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Altshuler's research on neuroanatomic abnormalities in patients with severe
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Over the last 25 years, the importance of this work has been recognized by
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repeatedly published in the most prestigious journals for both medicine (
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Veterans Administration Center of Excellence: Outpatient Bipolar Clinic
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American College of Psychiatrists Award for Research in Mood Disorders
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relapsed significantly more frequently (68%) over the course of their
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Over the past 30 years, Altshuler has published over 265 articles in
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period. Her work found that women who discontinued antidepressant
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During her residency, Altshuler completed several postmortem and
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Outstanding Research Mentor Award, UCLA Department of Psychiatry
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214:(August 23, 1957 – November 5, 2015) was a professor at the
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Gerald L. Klerman Distinguished Investigator Award, DBSA
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Altshuler has developed and pursued clinical and basic
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Distinguished Fellow, American Psychiatric Association
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Best Doctors in America® from 1996 to 2000, 2007–2008
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in Psychology (1978) and her M.D. degree (1982) from
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Daniel X. Freedman Young Investigator Award (NARSAD)
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activation is persistently lower among persons with
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596:"Lori Altshuler's Obituary on Los Angeles Times"
666:David Geffen School of Medicine at UCLA faculty
291:technique to assess structural changes in the
565:Julia S. Gouw Endowed Chair in Mood Disorders
426:antidepressant medications during pregnancy.
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405:after symptoms remit following a depressive
51:introducing citations to additional sources
496:Journal of the American Medical Association
373:is activated when bipolar patients enter a
273:differences in the brains of patients with
381:state. She concurrently demonstrated that
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437:supporting this work. Concurrently, the
433:(NIH), as she has received more than 22
41:Relevant discussion may be found on the
631:David Geffen School of Medicine at UCLA
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691:21st-century American women academics
681:20th-century American women academics
216:University of California, Los Angeles
200:University of California, Los Angeles
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671:Weill Cornell Medical College alumni
377:state and lower among patients in a
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256:National Institute of Mental Health
196:National Institute of Mental Health
365:has focused on both the gross and
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701:People from Englewood, New Jersey
16:American psychiatrist (1957–2015)
312:Department of Psychiatry at UCLA
242:, where she was a member of the
34:relies largely or entirely on a
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696:21st-century American academics
686:20th-century American academics
393:and other psychotic disorders.
248:UCLA Neuropsychiatric Institute
504:American Journal of Psychiatry
500:Archives of General Psychiatry
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431:National Institutes of Health
656:American women psychiatrists
234:Altshuler received both her
342:abnormalities in the major
168:Manhattan Beach, California
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322:and psychiatric research.
283:magnetic resonance imaging
258:(NIMH) from 1987 to 1989.
230:Education and early career
676:Cornell University alumni
498:, Brain) and psychiatry (
354:treatment of psychiatric
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334:in three primary areas:
439:Veterans Administration
350:of bipolar illness and
661:American psychiatrists
487:peer-reviewed journals
508:Biological Psychiatry
297:psychiatric disorders
150:Englewood, New Jersey
47:improve this article
604:. November 22, 2015
358:specific to women.
62:"Lori L. Altshuler"
447:Stanley Foundation
442:disorder and not.
326:Research interests
240:Cornell University
226:Hospital at UCLA.
179:Cornell University
627:Lori L. Altshuler
601:Los Angeles Times
536:Honors and awards
295:of patients with
263:clinical research
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130:Altshuler in 1997
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387:bipolar disorder
363:mental illnesses
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236:Bachelor of Arts
224:Neuropsychiatric
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36:single source
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608:November 17,
606:. Retrieved
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192:Institutions
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162:(2015-11-05)
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651:2015 deaths
646:1957 births
459:Parke-Davis
415:post-partum
640:Categories
582:References
419:medication
367:histologic
285:(MRI), an
271:postmortem
142:1957-08-23
73:newspapers
455:Eli Lilly
423:pregnancy
379:depressed
356:disorders
348:treatment
344:psychoses
340:cognitive
308:mentoring
304:professor
103:June 2020
43:talk page
371:amygdala
332:research
252:Hospital
629:at the
491:plenary
475:faculty
407:episode
398:bipolar
288:in vivo
87:scholar
506:, and
465:Career
451:Abbott
316:global
293:brains
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375:manic
94:JSTOR
80:books
610:2018
338:and
250:and
157:Died
136:Born
66:news
49:by
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