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29:
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InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
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Aravamudhan A, Ramos DM, Nip J, Subramanian A, James R, Harmon MD, et al. (2013). "Osteoinductive small molecules: growth factor alternatives for bone tissue engineering".
549:
Sharma S, Kaur A, Sharma S (April 2018). "Preconditioning potential of purmorphamine: a hedgehog activator against ischaemic reperfusion injury in ovariectomised rat heart".
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Wu X, Ding S, Ding Q, Gray NS, Schultz PG (December 2002). "A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells".
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Lee SJ, Lee HK, Cho SY, Choi JK, Shin HK, Kwak EJ, et al. (October 2008). "Identification of osteogenic purmorphamine derivatives".
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and brain development as well as having a number of other functions in the body. Purmorphamine has been shown to induce
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Stanton BZ, Peng LF (January 2010). "Small-molecule modulators of the Sonic
Hedgehog signaling pathway".
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Sinha S, Chen JK (January 2006). "Purmorphamine activates the
Hedgehog pathway by targeting Smoothened".
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in bone tissue as well as influencing growth and differentiation of neurons in the brain.
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C1(N(C2CCCCC2)C=N3)=C3C(NC4=CC=C(N5CCOCC5)C=C4)=NC(OC6=CC=CC7=C6C=CC=C7)=N1
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9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine
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was the first small-molecule agonist developed for the protein
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Wu X, Walker J, Zhang J, Ding S, Schultz PG (September 2004).
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310:cardiovascular regeneration
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107:ChemSpider
62:CAS Number
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551:Perfusion
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