43:
1091:
271:
1954:
Ezzeddini R, Darabi M, Ghasemi B, Jabbari
Moghaddam Y, Jabbari Y, Abdollahi S, et al. (April 2012). "Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis".
2848:
2201:
Guan M, Qu L, Tan W, Chen L, Wong CW (February 2011). "Hepatocyte nuclear factor-4 α regulates liver triglyceride metabolism in part through secreted phospholipase AA
417:
222:
373:
361:
285:
Middle plane of the lipid bilayer - black dots. Boundary of the hydrocarbon core region - red dots (extracellular side). Layer of lipid phosphates - yellow dots.
1046:, of the bridging water molecule. The rate limiting state is characterized as the degradation of the tetrahedral intermediate composed of a calcium coordinated
241:
1050:. The role of calcium can also be duplicated by other relatively small cations like cobalt and nickel. Before becoming active in digestion, the proform of PLA
1007:
water via a bridging second water molecule, w6. It has been suggested that two water molecules are necessary to traverse the distance between the catalytic
2841:
995:
is initiated by a His-48/Asp-99/calcium complex within the active site. The calcium ion polarizes the sn-2 carbonyl oxygen while also coordinating with a
3246:
1469:
958:
3493:
2834:
3879:
341:
3407:
1231:
In the case of an inflammation, the application of glucocorticoids up-regulate (mediated at the gene level) the production of the protein
3508:
3502:
3303:
3053:
791:
1076:. Calcium ion (pink) coordinates with phosphate (light blue). Phosphate mimics tetrahedral intermediate blocking substrate access to
3351:
3020:
560:
enzymes are commonly found in mammalian tissues as well as arachnid, insect, and snake venom. Venom from bees is largely composed of
3462:
3251:
2976:
2673:
1691:
1342:
1209:
833:
2293:
Six DA, Dennis EA (October 2000). "The expanding superfamily of phospholipase A(2) enzymes: classification and characterization".
1255:'s conversion into proinflammatory mediators and its reincorporation into the membrane. In the absence of strict regulation of PLA
1062:
234:
3569:
3457:
3378:
3288:
3241:
1214:
161:
437:
185:
3800:
3741:
2999:
2736:
Bell JG, MacKinlay EE, Dick JR, MacDonald DJ, Boyle RM, Glen AC (October 2004). "Essential fatty acids and phospholipase A
2479:
Pan YH, Epstein TM, Jain MK, Bahnson BJ (January 2001). "Five coplanar anion binding sites on one face of phospholipase A
2431:
Berg OG, Gelb MH, Tsai MD, Jain MK (September 2001). "Interfacial enzymology: the secreted phospholipase A(2)-paradigm".
1995:(GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor"
1907:
De Luca D, Minucci A, Cogo P, Capoluongo ED, Conti G, Pietrini D, et al. (January 2011). "Secretory phospholipase AA
3845:
3412:
3402:
2944:
975:
in atherosclerosis may depend on its carrier in plasma, and several lines of evidence suggest that HDL-associated Lp-PLA
581:
3805:
3697:
3322:
2980:
2693:
activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders".
3391:
3387:
3383:
3299:
3132:
1284:
1145:
action can release histamine from rat peritoneal mast cells. It also causes histamine release in human basophils.
1043:
3653:
3599:
3559:
3518:
3422:
3261:
3229:
3115:
3079:
2932:
1225:
1220:
3307:
3156:
3070:
3004:
2987:
2939:
2826:
2820:
755:
522:
179:
72:
847:, that have no phospholipase activity with typical phospholipase substrate. The lack of enzymatic activity of
425:
3176:
3046:
2994:
787:
783:
166:
3732:
3371:
2958:
1319:
1264:
859:
null mice, VLDL levels were greatly reduced, suggesting it could have an effect in lipoprotein secretion.
825:
3667:
3564:
3356:
3317:
3181:
3103:
2951:
2895:
1158:
779:
577:
526:
246:
421:
154:
3850:
3685:
3680:
3613:
3273:
3098:
2155:
2046:"sPLA2-IIa amplifies ocular surface inflammation in the experimental dry eye (DE) BALB/c mouse model"
1323:
1315:
1259:
activity, a disproportionate amount of proinflammatory mediators are produced. The resulting induced
630:
with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A
354:
89:
2093:
Chalbot S, Zetterberg H, Blennow K, Fladby T, Andreasen N, Grundke-Iqbal I, Iqbal K (January 2011).
1307:
could be a pharmaceutical approach to treatment of several disorders associated with neural trauma.
3705:
3675:
3479:
3474:
3398:
3334:
3120:
821:
84:
182:
3838:
3690:
3171:
3161:
3039:
2718:
2592:
2318:
1936:
1492:
1272:
911:
829:
106:
1448:
1442:
1436:
1402:
1396:
1384:
1287:(PAF). Abnormal levels of potent PAF are also associated with neurological damage. An optimal
1410:
3639:
3584:
3552:
3427:
3146:
2796:
2757:
2710:
2669:
2637:
2584:
2545:
2500:
2469:
2448:
2410:
2371:
2310:
2275:
2222:
2183:
2124:
2075:
2026:
1971:
1928:
1889:
1844:
1791:
1738:
1687:
1660:
1615:
1570:
1130:
884:
412:
173:
1511:
580:
disproportionately. As a result, inflammation and pain occur at the site. There are also
3715:
3295:
3195:
3151:
2861:
2816:
2788:
2749:
2702:
2627:
2576:
2535:
2492:
2440:
2402:
2361:
2353:
2302:
2265:
2257:
2214:
2173:
2163:
2144:"Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol"
2114:
2106:
2065:
2057:
2016:
2006:
1963:
1920:
1879:
1834:
1826:
1809:
Escoffier J, Jemel I, Tanemoto A, Taketomi Y, Payre C, Coatrieux C, et al. (May 2010).
1781:
1773:
1728:
1720:
1650:
1605:
1560:
1296:
1288:
1283:
are another class of molecules released from the membrane that are upstream predecessors of
1280:
1260:
1252:
1073:
1020:
907:
767:
694:
596:
573:
538:
518:
2142:
Aljakna A, Choi S, Savage H, Hageman Blair R, Gu T, Svenson KL, et al. (August 2012).
404:
3817:
3631:
3547:
3542:
3537:
3450:
3445:
3205:
3083:
2890:
2518:
Choi SH, Sakamoto T, Fukutomi O, Inagaki N, Matsuura N, Nagai H, Koda A (September 1989).
2336:
Wilensky RL, Shi Y, Mohler ER, Hamamdzic D, Burgert ME, Li J, et al. (October 2008).
1318:
that rises during inflammation, which is also seen to be exponentially higher in low back
1166:
1000:
968:
782:, and has been shown to promote vascular inflammation correlating with coronary events in
771:
611:
607:
603:
142:
56:
1639:
activity by mastoparans, a new class of mast cell degranulating peptides from wasp venom"
2159:
118:
3790:
3785:
3780:
3166:
3141:
3137:
3110:
3093:
2913:
2689:
Farooqui AA, Ong WY, Horrocks LA (September 2006). "Inhibitors of brain phospholipase A
2580:
2366:
2337:
2270:
2241:
2178:
2143:
2119:
2094:
2070:
2045:
2021:
1990:
1839:
1810:
1786:
1757:
1733:
1708:
1680:
1503:
1200:
899:
627:
592:
530:
217:
77:
2389:
Tellis CC, Tselepis AD (May 2009). "The role of lipoprotein-associated phospholipase A
2306:
1884:
1863:
1655:
1634:
1565:
1544:
366:
197:
3873:
3531:
3440:
3190:
1707:
Oliveira AL, Viegas MF, da Silva SL, Soares AM, Ramos MJ, Fernandes PA (2022-06-10).
1338:
1114:
931:
923:
876:
759:
667:
546:
496:
346:
192:
2596:
2322:
1989:
Henderson WR, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, Gelb MH (August 2011).
1940:
1911:
pathway during pediatric acute respiratory distress syndrome: a preliminary study".
1756:
Sato H, Taketomi Y, Isogai Y, Miki Y, Yamamoto K, Masuda S, et al. (May 2010).
310:
3658:
3589:
3312:
3233:
2722:
1300:
903:
751:
740:
534:
510:
472:
400:
1815:
is released during sperm acrosome reaction and controls fertility outcome in mice"
739:
are involved in sperm maturation, and group X are thought to be involved in sperm
378:
2406:
2168:
1967:
1924:
322:
3833:
3604:
3498:
3361:
3327:
3265:
3031:
2968:
2753:
1524:
1327:
1110:
1077:
927:
919:
795:
763:
679:
550:
201:
1724:
1588:
Nicolas JP, Lin Y, Lambeau G, Ghomashchi F, Lazdunski M, Gelb MH (March 1997).
3810:
2905:
2865:
2857:
1232:
1032:
1024:
915:
542:
514:
476:
468:
42:
2632:
2611:
770:. This arachidonic acid is then metabolized to form several inflammatory and
3723:
3522:
3435:
3062:
2110:
2011:
1610:
1589:
1186:
1081:
1070:
1008:
1004:
996:
988:
892:
721:
2800:
2761:
2714:
2540:
2519:
2504:
2452:
2414:
2375:
2314:
2279:
2226:
2187:
2128:
2079:
2044:
Wei Y, Epstein SP, Fukuoka S, Birmingham NP, Li XM, Asbell PA (July 2011).
2030:
1975:
1932:
1893:
1848:
1795:
1742:
1181:-505. When phosphorylation is coupled with an influx of calcium ions, cPLA
2792:
2641:
2588:
2549:
2295:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
1868:₂ in cardiovascular disease: roles as biological effectors and biomarkers"
1664:
1619:
1574:
1061:
350:
3768:
3763:
3758:
3579:
3214:
3066:
2261:
2061:
1486:
1276:
1268:
1122:
1047:
1016:
706:
698:
683:
561:
553:, which are categorized as anti-inflammatory and inflammatory mediators.
480:
317:
47:
Phospholipase cleavage sites. Note that an enzyme that displays both PLA
914:
and the precursor for the synthesis of other signaling molecules termed
3775:
3753:
3748:
3366:
2775:
Law MH, Cotton RG, Berger GE (June 2006). "The role of phospholipases A
2095:"Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease"
1478:
1430:
1424:
1418:
1390:
1378:
1370:
1361:
1118:
810:
710:
334:
329:
149:
130:
2706:
2496:
2473:
2444:
2218:
1545:"Diversity of group types, regulation, and function of phospholipase A
1090:
851:
indicates that it may have unique function distinctive from other sPLA
650:), also known as platelet activating factor acetylhydrolase (PAF-AH).
3795:
3728:
3621:
3219:
3127:
2869:
2393:
in atherosclerosis may depend on its lipoprotein carrier in plasma".
2242:"Hepatocyte nuclear factor 4α and downstream secreted phospholipase A
1830:
1777:
1499:
In addition, the following human proteins contain the phospholipase A
1463:
1456:
1346:
1178:
806:
702:
691:
432:
229:
125:
113:
101:
2563:
Morita Y, Aida N, Miyamoto T (August 1983). "Role of phospholipase A
2357:
1263:
and neuroinflammation is analogous to neurological diseases such as
979:
may substantially contribute to the HDL antiatherogenic activities.
17:
3737:
3488:
3484:
2923:
2918:
2240:
Li X, Jiang H, Qu L, Yao W, Cai H, Chen L, Peng T (January 2014).
1028:
1012:
729:
675:
1590:"Localization of structural elements of bee venom phospholipase A
1337:
has also been associated with neuropsychiatric disorders such as
728:. Venom phospholipases help to immobilize prey by promoting cell
3469:
3346:
3339:
3283:
3278:
1185:
becomes stimulated and can translocate to the membrane to begin
1174:
832:, and may serve as a marker of increases in permeability of the
687:
506:
394:
305:
137:
3035:
2830:
1133:
that are influential in regulation and stable protein folding.
270:
725:
1027:
substitution for His-48 maintains wild-type activity, as the
805:
have been associated with inflammation thought to exacerbate
2342:
reduces complex coronary atherosclerotic plaque development"
1762:
regulates epididymal sperm maturation and fertility in mice"
1196:
may be a result of ligand binding to receptors, including:
967:
are associated with cardiac disease, and may contribute to
2524:-induced histamine release from rat peritoneal mast cells"
2246:
GXIIB regulate production of infectious hepatitis C virus"
1709:"The chemistry of snake venom and its medicinal potential"
1109:
can also be characterized as having a channel featuring a
910:
from membrane phospholipids. Arachidonic acid is both a
2742:
Prostaglandins, Leukotrienes, and
Essential Fatty Acids
2612:"Properties and regulation of cytosolic phospholipase A
2567:
activation in histamine release from human basophils".
2666:
Medical
Physiology: A Cellular And Molecular Approaoch
1956:
International
Journal of Pediatric Otorhinolaryngology
1594:
involved in N-type receptor binding and neurotoxicity"
1125:
serve to bind the substrate. Another component of PLA
1113:
wall in which hydrophobic amino acid residues such as
479:
the bond between the second fatty acid "tail" and the
2338:"Inhibition of lipoprotein-associated phospholipase A
1864:"Lipoprotein-associated and secreted phospholipases A
1084:-48, Asp-99, and two water molecules are also shown.
568:. Due to the increased presence and activity of PLA
3826:
3714:
3666:
3652:
3630:
3612:
3598:
3578:
3517:
3421:
3260:
3228:
3078:
3013:
2967:
2904:
2876:
1991:"Blockade of human group X secreted phospholipase A
431:
411:
393:
388:
372:
360:
340:
328:
316:
304:
296:
291:
260:
240:
228:
216:
211:
191:
172:
160:
148:
136:
124:
112:
100:
95:
83:
71:
66:
32:
1679:
3357:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
1349:), though the mechanisms involved are not known.
883:are also Ca-dependent, but they have a different
839:There are atypical members of the phospholipase A
2050:Investigative Ophthalmology & Visual Science
1295:activity on neural cell membranes already under
1862:Mallat Z, Lambeau G, Tedgui A (November 2010).
754:in mammals by catalyzing the first step of the
491:O = 1-acylglycerophosphocholine + a carboxylate
1161:, regulation of the enzyme is essential. cPLA
941:can be classified based on sequence homology.
887:and are significantly larger than secreted PLA
3047:
2842:
1686:(4th ed.). San Francisco: W.H. Freeman.
8:
2426:
2424:
1019:of His-48 is thought to be enhanced through
2659:
2657:
2655:
2653:
2651:
634:. Other families include Ca independent PLA
3663:
3609:
3595:
3054:
3040:
3032:
2849:
2835:
2827:
1251:regulation accounts for a balance between
385:
269:
208:
41:
2819:at the U.S. National Library of Medicine
2631:
2539:
2520:"Pharmacological study of phospholipase A
2365:
2269:
2177:
2167:
2118:
2069:
2020:
2010:
1883:
1838:
1785:
1732:
1654:
1609:
1564:
891:(more than 700 residues). They include a
541:is modified into active compounds called
1303:. Thus, specific inhibitors of brain PLA
1094:Mechanism of hydrolysis catalyzed by PLA
1089:
1060:
999:water molecule, w5. His-48 improves the
926:. Some eicosanoids are synthesized from
3247:Ubiquitin carboxy-terminal hydrolase L1
1678:Cox M, Nelson DR, Lehninger AL (2005).
1633:Argiolas A, Pisano JJ (November 1983).
1535:
1326:. It is a mixture of inflammation and
959:Lipoprotein-associated phospholipase A2
572:resulting from a snake or insect bite,
2483:: relationship to interface binding".
1239:and reduce the inflammatory response.
257:
29:
3827:either deoxy- or ribo-
1819:The Journal of Clinical Investigation
1766:The Journal of Clinical Investigation
898:These phospholipases are involved in
724:of phospholipid compounds in dietary
7:
3408:Protein serine/threonine phosphatase
1682:Lehninger principles of biochemistry
778:is thought to contribute to several
690:), and from virtually every studied
3509:Cyclic nucleotide phosphodiesterase
3503:Clostridium perfringens alpha toxin
3304:Tartrate-resistant acid phosphatase
2620:The Journal of Biological Chemistry
1999:The Journal of Biological Chemistry
1758:"Group III secreted phospholipase A
1643:The Journal of Biological Chemistry
1598:The Journal of Biological Chemistry
1553:The Journal of Biological Chemistry
1243:Relevance in neurological disorders
792:acute respiratory distress syndrome
529:. Upon downstream modification by
465:phosphatidylcholine 2-acylhydrolase
3352:Pyruvate dehydrogenase phosphatase
2668:. Elsevier/Saunders. p. 103.
2581:10.1111/j.1398-9995.1983.tb05084.x
801:In children, excess levels of sPLA
674:have been isolated from different
25:
3252:4-hydroxybenzoyl-CoA thioesterase
2977:5-Lipoxygenase activating protein
2740:in autistic spectrum disorders".
1885:10.1161/CIRCULATIONAHA.110.936393
1343:pervasive developmental disorders
1169:and calcium concentrations. cPLA
834:blood-cerebrospinal fluid barrier
809:and ocular surface inflammation (
1913:Pediatric Critical Care Medicine
1635:"Facilitation of phospholipase A
1035:can also function to lower the p
934:by phospholipase C (see below).
774:molecules. Excess levels of sPLA
762:, resulting in the formation of
642:) and lipoprotein-associated PLA
3570:N-acetylglucosamine-6-sulfatase
3458:Sphingomyelin phosphodiesterase
2528:Journal of Pharmacobio-Dynamics
1330:that are responsible for pain.
3379:Inositol-phosphate phosphatase
3242:Palmitoyl protein thioesterase
2099:Journal of Alzheimer's Disease
895:and a large catalytic domain.
1:
3742:RNA-induced silencing complex
3000:Gamma-glutamyl transpeptidase
2988:LTA4 hydrolase (B4 synthesis)
2395:Biochimica et Biophysica Acta
2307:10.1016/S1388-1981(00)00105-0
1656:10.1016/S0021-9258(17)43973-1
1566:10.1016/S0021-9258(17)36794-7
1291:would specifically target PLA
971:. However, the role of Lp-PLA
564:, which is a stimulant of PLA
389:Available protein structures:
3880:Peripheral membrane proteins
3846:Serratia marcescens nuclease
3413:Dual-specificity phosphatase
3403:Protein tyrosine phosphatase
2945:Prostaglandin-E2 9-reductase
2407:10.1016/j.bbalip.2009.02.015
2169:10.1371/journal.pone.0043139
1968:10.1016/j.ijporl.2011.12.026
1925:10.1097/PCC.0b013e3181dbe95e
1153:Due to the importance of PLA
991:mechanism of pancreatic sPLA
855:. It has been shown that in
820:activity is observed in the
499:specifically recognizes the
467:) catalyses the cleavage of
3323:Fructose 1,6-bisphosphatase
2981:Arachidonate 5-lipoxygenase
2754:10.1016/j.plefa.2004.03.008
1310:Increase in phospholipase A
1285:platelet activating factors
27:Peripheral membrane protein
3896:
1725:10.1038/s41570-022-00393-7
1247:In normal brain cells, PLA
1044:acid dissociation constant
963:Increased levels of Lp-PLA
956:
945:Lipoprotein-associated PLA
863:Cytosolic phospholipases A
790:, and possibly leading to
750:has been shown to promote
626:include several unrelated
3560:Galactosamine-6 sulfatase
3116:6-phosphogluconolactonase
1713:Nature Reviews. Chemistry
1333:Increased phospholipase A
1065:Close-up rendering of PLA
1054:is activated by trypsin.
670:forms of phospholipases A
654:Secreted phospholipases A
384:
275:Bee venom phospholipase A
268:
207:
40:
3308:Purple acid phosphatases
2821:Medical Subject Headings
2633:10.1074/jbc.272.27.16709
1811:"Group X phospholipase A
756:arachidonic acid pathway
545:. Eicosanoids include
523:lysophosphatidyl choline
2695:Pharmacological Reviews
2610:Leslie CC (July 1997).
2111:10.3233/JAD-2011-101959
2012:10.1074/jbc.M111.235812
1611:10.1074/jbc.272.11.7173
1192:Phosphorylation of cPLA
1173:is phosphorylated by a
788:acute coronary syndrome
784:coronary artery disease
735:In mice, group III sPLA
487:phosphatidylcholine + H
55:activities is called a
3733:Microprocessor complex
3372:Beta-propeller phytase
2541:10.1248/bpb1978.12.517
1543:Dennis EA (May 1994).
1235:which may inhibit cPLA
1159:inflammatory responses
1098:
1085:
720:serve for the initial
3668:Endodeoxyribonuclease
3565:Iduronate-2-sulfatase
3318:Glucose 6-phosphatase
3104:Butyrylcholinesterase
2896:Diacylglycerol lipase
2793:10.1038/sj.mp.4001819
1357:Human phospholipase A
1093:
1064:
904:inflammatory response
780:inflammatory diseases
578:phospholipid membrane
576:is released from the
527:lysophosphatidic acid
3851:Micrococcal nuclease
3686:Deoxyribonuclease IV
3681:Deoxyribonuclease II
3614:Exodeoxyribonuclease
3274:Alkaline phosphatase
3099:Acetylcholinesterase
2781:Molecular Psychiatry
2262:10.1128/JVI.02068-13
2062:10.1167/iovs.10-6350
1324:rheumatoid arthritis
1316:acute-phase reaction
1031:functional group on
930:, released from the
591:Additional types of
517:the bond, releasing
3706:UvrABC endonuclease
3676:Deoxyribonuclease I
3399:Protein phosphatase
3335:Protein phosphatase
3133:Bile salt-dependent
3121:PAF acetylhydrolase
2779:in schizophrenia".
2626:(27): 16709–16712.
2250:Journal of Virology
2160:2012PLoSO...743139A
2005:(32): 28049–28055.
1649:(22): 13697–13702.
1559:(18): 13057–13060.
1265:Alzheimer's disease
902:processes, such as
826:Alzheimer's disease
822:cerebrospinal fluid
794:and progression of
3839:Mung bean nuclease
3698:Restriction enzyme
3691:Restriction enzyme
1273:multiple sclerosis
1137:Biological effects
1099:
1086:
912:signaling molecule
830:multiple sclerosis
705:) as well as from
513:and catalytically
463:, systematic name
3867:
3866:
3863:
3862:
3859:
3858:
3648:
3647:
3640:Oligonucleotidase
3585:deoxyribonuclease
3553:Steroid sulfatase
3428:Phosphodiesterase
3157:Hormone-sensitive
3029:
3028:
2707:10.1124/pr.58.3.7
2664:Boron WF (2003).
2497:10.1021/bi002514g
2445:10.1021/cr990139w
2352:(10): 1059–1066.
2219:10.1002/hep.24066
1878:(21): 2183–2200.
1604:(11): 7173–7181.
1281:Lysophospholipids
1131:disulfide bridges
1103:
1102:
1069:active site with
1023:with Asp-99. An
758:by breaking down
525:, a precursor of
471:in position 2 of
447:
446:
443:
442:
438:structure summary
286:
256:
255:
252:
251:
155:metabolic pathway
16:(Redirected from
3887:
3716:Endoribonuclease
3702:
3696:
3664:
3610:
3596:
3296:Acid phosphatase
3177:Monoacylglycerol
3087:ester hydrolases
3056:
3049:
3042:
3033:
2884:Phospholipase A2
2862:lipid metabolism
2851:
2844:
2837:
2828:
2817:Phospholipase+A2
2805:
2804:
2772:
2766:
2765:
2733:
2727:
2726:
2686:
2680:
2679:
2661:
2646:
2645:
2635:
2607:
2601:
2600:
2560:
2554:
2553:
2543:
2515:
2509:
2508:
2476:
2466:
2460:
2459:
2439:(9): 2613–2654.
2433:Chemical Reviews
2428:
2419:
2418:
2386:
2380:
2379:
2369:
2333:
2327:
2326:
2290:
2284:
2283:
2273:
2237:
2231:
2230:
2198:
2192:
2191:
2181:
2171:
2139:
2133:
2132:
2122:
2090:
2084:
2083:
2073:
2056:(7): 4780–4788.
2041:
2035:
2034:
2024:
2014:
1986:
1980:
1979:
1951:
1945:
1944:
1904:
1898:
1897:
1887:
1859:
1853:
1852:
1842:
1831:10.1172/JCI40494
1825:(5): 1415–1428.
1806:
1800:
1799:
1789:
1778:10.1172/JCI40493
1772:(5): 1400–1414.
1753:
1747:
1746:
1736:
1704:
1698:
1697:
1685:
1675:
1669:
1668:
1658:
1630:
1624:
1623:
1613:
1585:
1579:
1578:
1568:
1540:
1320:disc herniations
1297:oxidative stress
1289:enzyme inhibitor
1261:oxidative stress
1253:arachidonic acid
1165:is regulated by
1074:enzyme inhibitor
1057:
1056:
1021:hydrogen bonding
937:Phospholipases A
918:. These include
908:arachidonic acid
843:family, such as
768:arachidonic acid
709:. They require
628:protein families
622:Phospholipases A
574:arachidonic acid
539:arachidonic acid
519:arachidonic acid
495:This particular
386:
284:
273:
258:
209:
45:
30:
21:
3895:
3894:
3890:
3889:
3888:
3886:
3885:
3884:
3870:
3869:
3868:
3855:
3822:
3710:
3700:
3694:
3657:
3644:
3632:Exoribonuclease
3626:
3603:
3587:
3583:
3574:
3548:Arylsulfatase L
3543:Arylsulfatase B
3538:Arylsulfatase A
3513:
3426:
3417:
3256:
3224:
3086:
3074:
3060:
3030:
3025:
3009:
2963:
2900:
2891:Phospholipase C
2872:
2855:
2813:
2808:
2778:
2774:
2773:
2769:
2739:
2735:
2734:
2730:
2692:
2688:
2687:
2683:
2676:
2663:
2662:
2649:
2615:
2609:
2608:
2604:
2566:
2562:
2561:
2557:
2523:
2517:
2516:
2512:
2482:
2478:
2468:
2467:
2463:
2430:
2429:
2422:
2392:
2388:
2387:
2383:
2358:10.1038/nm.1870
2346:Nature Medicine
2341:
2335:
2334:
2330:
2292:
2291:
2287:
2245:
2239:
2238:
2234:
2204:
2200:
2199:
2195:
2141:
2140:
2136:
2092:
2091:
2087:
2043:
2042:
2038:
1994:
1988:
1987:
1983:
1953:
1952:
1948:
1910:
1906:
1905:
1901:
1867:
1861:
1860:
1856:
1814:
1808:
1807:
1803:
1761:
1755:
1754:
1750:
1706:
1705:
1701:
1694:
1677:
1676:
1672:
1638:
1632:
1631:
1627:
1593:
1587:
1586:
1582:
1548:
1542:
1541:
1537:
1533:
1521:
1502:
1360:
1355:
1336:
1314:activity is an
1313:
1306:
1294:
1258:
1250:
1245:
1238:
1204:
1195:
1184:
1172:
1167:phosphorylation
1164:
1156:
1151:
1144:
1139:
1128:
1108:
1097:
1068:
1053:
1041:
1001:nucleophilicity
994:
985:
978:
974:
969:atherosclerosis
966:
961:
955:
952:
948:
940:
906:. They release
890:
882:
873:
870:
866:
854:
842:
824:of humans with
819:
804:
777:
749:
738:
719:
716:Pancreatic sPLA
673:
664:
661:
657:
649:
645:
641:
637:
633:
625:
620:
612:phospholipase D
608:phospholipase C
604:phospholipase B
600:
597:phospholipase A
585:
571:
567:
559:
531:cyclooxygenases
505:
490:
461:
454:
451:phospholipase A
362:OPM superfamily
300:Phospholip_A2_1
287:
282:
278:
264:
261:Phospholipase A
62:
57:phospholipase B
54:
50:
36:
33:phospholipase A
28:
23:
22:
15:
12:
11:
5:
3893:
3891:
3883:
3882:
3872:
3871:
3865:
3864:
3861:
3860:
3857:
3856:
3854:
3853:
3848:
3843:
3842:
3841:
3830:
3828:
3824:
3823:
3821:
3820:
3815:
3814:
3813:
3808:
3803:
3798:
3788:
3783:
3778:
3773:
3772:
3771:
3766:
3761:
3756:
3746:
3745:
3744:
3735:
3720:
3718:
3712:
3711:
3709:
3708:
3703:
3688:
3683:
3678:
3672:
3670:
3661:
3650:
3649:
3646:
3645:
3643:
3642:
3636:
3634:
3628:
3627:
3625:
3624:
3618:
3616:
3607:
3593:
3576:
3575:
3573:
3572:
3567:
3562:
3557:
3556:
3555:
3550:
3545:
3540:
3527:
3525:
3515:
3514:
3512:
3511:
3506:
3496:
3491:
3482:
3477:
3472:
3467:
3466:
3465:
3455:
3454:
3453:
3448:
3438:
3432:
3430:
3419:
3418:
3416:
3415:
3410:
3405:
3396:
3395:
3394:
3376:
3375:
3374:
3364:
3359:
3354:
3349:
3344:
3343:
3342:
3332:
3331:
3330:
3320:
3315:
3310:
3293:
3292:
3291:
3286:
3281:
3270:
3268:
3258:
3257:
3255:
3254:
3249:
3244:
3238:
3236:
3226:
3225:
3223:
3222:
3217:
3211:
3210:
3209:
3208:
3203:
3198:
3187:
3186:
3185:
3184:
3182:Diacylglycerol
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3135:
3124:
3123:
3118:
3113:
3111:Pectinesterase
3108:
3107:
3106:
3101:
3094:Cholinesterase
3090:
3088:
3076:
3075:
3061:
3059:
3058:
3051:
3044:
3036:
3027:
3026:
3024:
3023:
3017:
3015:
3011:
3010:
3008:
3007:
3005:LTD4 hydrolase
3002:
2997:
2991:
2990:
2984:
2983:
2973:
2971:
2965:
2964:
2962:
2961:
2955:
2954:
2948:
2947:
2942:
2936:
2935:
2929:
2928:
2927:
2926:
2921:
2914:Cyclooxygenase
2910:
2908:
2902:
2901:
2899:
2898:
2893:
2887:
2886:
2880:
2878:
2874:
2873:
2856:
2854:
2853:
2846:
2839:
2831:
2825:
2824:
2812:
2811:External links
2809:
2807:
2806:
2787:(6): 547–556.
2776:
2767:
2748:(4): 201–204.
2737:
2728:
2701:(3): 591–620.
2690:
2681:
2674:
2647:
2613:
2602:
2575:(6): 413–418.
2564:
2555:
2534:(9): 517–522.
2521:
2510:
2491:(3): 609–617.
2480:
2461:
2420:
2401:(5): 327–338.
2390:
2381:
2339:
2328:
2285:
2256:(1): 612–627.
2243:
2232:
2213:(2): 458–466.
2202:
2193:
2134:
2105:(3): 505–515.
2085:
2036:
1992:
1981:
1962:(4): 471–474.
1946:
1919:(1): e20–e24.
1908:
1899:
1865:
1854:
1812:
1801:
1759:
1748:
1719:(7): 451–469.
1699:
1692:
1670:
1636:
1625:
1591:
1580:
1546:
1534:
1532:
1529:
1528:
1527:
1520:
1517:
1516:
1515:
1500:
1497:
1496:
1482:
1474:
1466:
1460:
1452:
1414:
1406:
1374:
1358:
1354:
1351:
1334:
1311:
1304:
1292:
1256:
1248:
1244:
1241:
1236:
1229:
1228:
1226:IFN-γ receptor
1223:
1221:IFN-α receptor
1218:
1212:
1207:
1202:
1193:
1182:
1170:
1162:
1154:
1150:
1147:
1142:
1138:
1135:
1126:
1106:
1101:
1100:
1095:
1087:
1066:
1051:
1039:
992:
987:The suggested
984:
981:
976:
972:
964:
957:Main article:
954:
950:
946:
943:
938:
928:diacylglycerol
924:prostaglandins
900:cell signaling
888:
880:
879:, group IV PLA
872:
868:
864:
861:
852:
840:
817:
816:Increased sPLA
802:
775:
747:
736:
717:
713:for activity.
671:
663:
659:
655:
652:
647:
643:
639:
635:
631:
623:
619:
616:
598:
593:phospholipases
586:phospholipases
583:
569:
565:
557:
547:prostaglandins
503:
493:
492:
488:
459:
452:
445:
444:
441:
440:
435:
429:
428:
415:
409:
408:
398:
391:
390:
382:
381:
376:
370:
369:
364:
358:
357:
344:
338:
337:
332:
326:
325:
320:
314:
313:
308:
302:
301:
298:
294:
293:
289:
288:
280:
276:
274:
266:
265:
262:
254:
253:
250:
249:
244:
238:
237:
232:
226:
225:
220:
214:
213:
205:
204:
195:
189:
188:
177:
170:
169:
164:
158:
157:
152:
146:
145:
140:
134:
133:
128:
122:
121:
116:
110:
109:
104:
98:
97:
93:
92:
87:
81:
80:
75:
69:
68:
64:
63:
52:
48:
46:
38:
37:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3892:
3881:
3878:
3877:
3875:
3852:
3849:
3847:
3844:
3840:
3837:
3836:
3835:
3832:
3831:
3829:
3825:
3819:
3816:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3793:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3751:
3750:
3747:
3743:
3739:
3736:
3734:
3730:
3727:
3726:
3725:
3722:
3721:
3719:
3717:
3713:
3707:
3704:
3699:
3692:
3689:
3687:
3684:
3682:
3679:
3677:
3674:
3673:
3671:
3669:
3665:
3662:
3660:
3655:
3651:
3641:
3638:
3637:
3635:
3633:
3629:
3623:
3620:
3619:
3617:
3615:
3611:
3608:
3606:
3601:
3597:
3594:
3591:
3586:
3581:
3577:
3571:
3568:
3566:
3563:
3561:
3558:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3535:
3534:
3533:
3532:arylsulfatase
3529:
3528:
3526:
3524:
3520:
3516:
3510:
3507:
3504:
3500:
3497:
3495:
3492:
3490:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3464:
3461:
3460:
3459:
3456:
3452:
3449:
3447:
3444:
3443:
3442:
3441:Phospholipase
3439:
3437:
3434:
3433:
3431:
3429:
3424:
3420:
3414:
3411:
3409:
3406:
3404:
3400:
3397:
3393:
3389:
3385:
3382:
3381:
3380:
3377:
3373:
3370:
3369:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3341:
3338:
3337:
3336:
3333:
3329:
3326:
3325:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3305:
3301:
3297:
3294:
3290:
3287:
3285:
3282:
3280:
3277:
3276:
3275:
3272:
3271:
3269:
3267:
3263:
3259:
3253:
3250:
3248:
3245:
3243:
3240:
3239:
3237:
3235:
3231:
3227:
3221:
3218:
3216:
3213:
3212:
3207:
3204:
3202:
3199:
3197:
3194:
3193:
3192:
3191:Phospholipase
3189:
3188:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3139:
3136:
3134:
3131:
3130:
3129:
3126:
3125:
3122:
3119:
3117:
3114:
3112:
3109:
3105:
3102:
3100:
3097:
3096:
3095:
3092:
3091:
3089:
3085:
3081:
3077:
3072:
3068:
3064:
3057:
3052:
3050:
3045:
3043:
3038:
3037:
3034:
3022:
3019:
3018:
3016:
3012:
3006:
3003:
3001:
2998:
2996:
2995:LTC4 synthase
2993:
2992:
2989:
2986:
2985:
2982:
2978:
2975:
2974:
2972:
2970:
2966:
2960:
2957:
2956:
2953:
2952:PGI2 synthase
2950:
2949:
2946:
2943:
2941:
2938:
2937:
2934:
2933:PGD2 synthase
2931:
2930:
2925:
2922:
2920:
2917:
2916:
2915:
2912:
2911:
2909:
2907:
2903:
2897:
2894:
2892:
2889:
2888:
2885:
2882:
2881:
2879:
2875:
2871:
2867:
2863:
2859:
2852:
2847:
2845:
2840:
2838:
2833:
2832:
2829:
2822:
2818:
2815:
2814:
2810:
2802:
2798:
2794:
2790:
2786:
2782:
2771:
2768:
2763:
2759:
2755:
2751:
2747:
2743:
2732:
2729:
2724:
2720:
2716:
2712:
2708:
2704:
2700:
2696:
2685:
2682:
2677:
2675:1-4160-2328-3
2671:
2667:
2660:
2658:
2656:
2654:
2652:
2648:
2643:
2639:
2634:
2629:
2625:
2621:
2617:
2606:
2603:
2598:
2594:
2590:
2586:
2582:
2578:
2574:
2570:
2559:
2556:
2551:
2547:
2542:
2537:
2533:
2529:
2525:
2514:
2511:
2506:
2502:
2498:
2494:
2490:
2486:
2475:
2471:
2465:
2462:
2458:
2457:See page 2640
2454:
2450:
2446:
2442:
2438:
2434:
2427:
2425:
2421:
2416:
2412:
2408:
2404:
2400:
2396:
2385:
2382:
2377:
2373:
2368:
2363:
2359:
2355:
2351:
2347:
2343:
2332:
2329:
2324:
2320:
2316:
2312:
2308:
2304:
2301:(1–2): 1–19.
2300:
2296:
2289:
2286:
2281:
2277:
2272:
2267:
2263:
2259:
2255:
2251:
2247:
2236:
2233:
2228:
2224:
2220:
2216:
2212:
2208:
2197:
2194:
2189:
2185:
2180:
2175:
2170:
2165:
2161:
2157:
2154:(8): e43139.
2153:
2149:
2145:
2138:
2135:
2130:
2126:
2121:
2116:
2112:
2108:
2104:
2100:
2096:
2089:
2086:
2081:
2077:
2072:
2067:
2063:
2059:
2055:
2051:
2047:
2040:
2037:
2032:
2028:
2023:
2018:
2013:
2008:
2004:
2000:
1996:
1985:
1982:
1977:
1973:
1969:
1965:
1961:
1957:
1950:
1947:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1903:
1900:
1895:
1891:
1886:
1881:
1877:
1873:
1869:
1858:
1855:
1850:
1846:
1841:
1836:
1832:
1828:
1824:
1820:
1816:
1805:
1802:
1797:
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1779:
1775:
1771:
1767:
1763:
1752:
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1740:
1735:
1730:
1726:
1722:
1718:
1714:
1710:
1703:
1700:
1695:
1693:0-7167-4339-6
1689:
1684:
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1674:
1671:
1666:
1662:
1657:
1652:
1648:
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1617:
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1599:
1595:
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1539:
1536:
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1438:
1433:
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1427:
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1412:
1407:
1405:
1404:
1399:
1398:
1393:
1392:
1387:
1386:
1381:
1380:
1375:
1373:
1372:
1367:
1366:
1365:
1363:
1352:
1350:
1348:
1344:
1340:
1339:schizophrenia
1331:
1329:
1325:
1321:
1317:
1308:
1302:
1298:
1290:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1254:
1242:
1240:
1234:
1227:
1224:
1222:
1219:
1216:
1213:
1211:
1208:
1206:
1199:
1198:
1197:
1190:
1188:
1180:
1176:
1168:
1160:
1148:
1146:
1136:
1134:
1132:
1129:is the seven
1124:
1120:
1116:
1112:
1092:
1088:
1083:
1079:
1075:
1072:
1063:
1059:
1058:
1055:
1049:
1045:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
990:
982:
980:
970:
960:
944:
942:
935:
933:
932:lipid bilayer
929:
925:
921:
917:
913:
909:
905:
901:
896:
894:
886:
878:
877:intracellular
862:
860:
858:
850:
846:
837:
835:
831:
827:
823:
814:
812:
808:
799:
797:
793:
789:
785:
781:
773:
769:
765:
761:
760:phospholipids
757:
753:
744:
742:
733:
731:
727:
723:
714:
712:
708:
704:
700:
696:
693:
689:
685:
681:
677:
669:
668:extracellular
653:
651:
629:
617:
615:
613:
609:
605:
601:
594:
589:
587:
582:prokaryotic A
579:
575:
563:
554:
552:
548:
544:
540:
536:
535:lipoxygenases
532:
528:
524:
520:
516:
512:
511:phospholipids
508:
502:
498:
497:phospholipase
486:
485:
484:
482:
478:
474:
473:phospholipids
470:
466:
462:
456:(EC 3.1.1.4,
455:
439:
436:
434:
430:
427:
423:
419:
416:
414:
410:
406:
402:
399:
396:
392:
387:
383:
380:
377:
375:
371:
368:
365:
363:
359:
356:
352:
348:
345:
343:
339:
336:
333:
331:
327:
324:
321:
319:
315:
312:
309:
307:
303:
299:
295:
290:
272:
267:
259:
248:
245:
243:
239:
236:
233:
231:
227:
224:
221:
219:
215:
210:
206:
203:
199:
196:
194:
193:Gene Ontology
190:
187:
184:
181:
178:
175:
171:
168:
165:
163:
159:
156:
153:
151:
147:
144:
141:
139:
135:
132:
131:NiceZyme view
129:
127:
123:
120:
117:
115:
111:
108:
105:
103:
99:
94:
91:
88:
86:
82:
79:
76:
74:
70:
65:
61:
58:
44:
39:
31:
19:
3701:}}
3695:{{
3659:Endonuclease
3590:ribonuclease
3530:
3313:Nucleotidase
3234:Thioesterase
3200:
2969:Leukotrienes
2959:TXA synthase
2940:PGE synthase
2883:
2784:
2780:
2770:
2745:
2741:
2731:
2698:
2694:
2684:
2665:
2623:
2619:
2605:
2572:
2568:
2558:
2531:
2527:
2513:
2488:
2485:Biochemistry
2484:
2464:
2456:
2436:
2432:
2398:
2394:
2384:
2349:
2345:
2331:
2298:
2294:
2288:
2253:
2249:
2235:
2210:
2206:
2196:
2151:
2147:
2137:
2102:
2098:
2088:
2053:
2049:
2039:
2002:
1998:
1984:
1959:
1955:
1949:
1916:
1912:
1902:
1875:
1871:
1857:
1822:
1818:
1804:
1769:
1765:
1751:
1716:
1712:
1702:
1681:
1673:
1646:
1642:
1628:
1601:
1597:
1583:
1556:
1552:
1538:
1510:
1498:
1491:
1485:
1477:
1470:
1455:
1447:
1441:
1435:
1429:
1423:
1417:
1409:
1401:
1395:
1389:
1383:
1377:
1369:
1356:
1332:
1322:compared to
1309:
1301:inflammation
1246:
1230:
1191:
1152:
1140:
1104:
1036:
986:
962:
936:
920:leukotrienes
897:
885:3D structure
874:
856:
848:
844:
838:
815:
800:
772:thrombogenic
752:inflammation
745:
741:capacitation
734:
715:
665:
621:
590:
555:
551:leukotrienes
500:
494:
464:
457:
450:
448:
119:BRENDA entry
60:
3834:Nuclease S1
3605:Exonuclease
3499:Lecithinase
3328:Calcineurin
3266:Phosphatase
3172:Lipoprotein
3162:Endothelial
2906:Prostanoids
2868:metabolism
1872:Circulation
1525:Paul Sigler
1484:Group XII:
1468:Group VII:
1408:Group III:
1328:substance P
1299:and potent
1111:hydrophobic
1078:active site
916:eicosanoids
796:tonsillitis
764:fatty acids
697:(including
543:eicosanoids
477:hydrolyzing
469:fatty acids
449:The enzyme
374:OPM protein
292:Identifiers
107:IntEnz view
67:Identifiers
3147:Pancreatic
3084:Carboxylic
2866:eicosanoid
2858:Metabolism
2207:Hepatology
1531:References
1462:Group VI:
1416:Group IV:
1376:Group II:
1233:lipocortin
1149:Regulation
1033:asparagine
1025:asparagine
766:including
515:hydrolyzes
483:molecule:
401:structures
176:structures
143:KEGG entry
90:9001-84-7
3724:RNase III
3582:(includes
3523:Sulfatase
3436:Autotaxin
3300:Prostatic
3152:Lysosomal
3067:esterases
3063:Hydrolase
3014:Ungrouped
2877:Precursor
2477:;
1476:Group X:
1454:Group V:
1368:Group I:
1364:include:
1345:(such as
1205:receptors
1187:catalysis
1071:phosphate
1009:histidine
1005:catalytic
997:catalytic
989:catalytic
983:Mechanism
893:C2 domain
722:digestion
692:mammalian
335:PDOC00109
323:IPR001211
96:Databases
3874:Category
3818:RNase T1
3580:Nuclease
3215:Cutinase
2801:16585943
2762:15301788
2715:16968951
2597:42671016
2505:11170377
2453:11749391
2415:19272461
2376:18806801
2323:23717374
2315:11080672
2280:24173221
2227:21274867
2205:GXIIB".
2188:22912808
2148:PLOS ONE
2129:21471645
2080:21519031
2031:21652694
1976:22297210
1941:36962872
1933:20351613
1894:21098459
1849:20424324
1796:20424323
1743:35702592
1519:See also
1493:PLA2G12B
1487:PLA2G12A
1362:isozymes
1353:Isozymes
1277:ischemia
1269:epilepsy
1217:receptor
1048:oxyanion
1017:basicity
1011:and the
857:PLA2G12B
849:PLA2G12B
845:PLA2G12B
707:bacteria
699:pancreas
618:Families
595:include
562:melittin
509:bond of
481:glycerol
418:RCSB PDB
318:InterPro
247:proteins
235:articles
223:articles
180:RCSB PDB
3791:RNase E
3786:RNase Z
3781:RNase A
3776:RNase P
3749:RNase H
3367:Phytase
3167:Hepatic
3142:Lingual
3138:Gastric
2870:enzymes
2723:6137443
2642:9201969
2589:6194706
2569:Allergy
2550:2482349
2367:2885134
2271:3911757
2179:3422231
2156:Bibcode
2120:3139450
2071:3175946
2022:3151050
1840:2860919
1787:2860917
1734:9185726
1665:6643447
1620:9054413
1575:8175726
1479:PLA2G10
1449:PLA2G4F
1443:PLA2G4E
1437:PLA2G4D
1431:PLA2G4C
1425:PLA2G4B
1419:PLA2G4A
1403:PLA2G2F
1397:PLA2G2E
1391:PLA2G2D
1385:PLA2G2C
1379:PLA2G2A
1371:PLA2G1B
1003:of the
949:(Lp-PLA
811:dry eye
646:(Lp-PLA
330:PROSITE
311:PF00068
202:QuickGO
167:profile
150:MetaCyc
85:CAS no.
78:3.1.1.4
51:and PLA
3729:Drosha
3654:3.1.21
3622:RecBCD
3600:3.1.11
3220:PETase
3128:Lipase
2823:(MeSH)
2799:
2760:
2721:
2713:
2672:
2640:
2595:
2587:
2548:
2503:
2451:
2413:
2374:
2364:
2321:
2313:
2278:
2268:
2225:
2186:
2176:
2127:
2117:
2078:
2068:
2029:
2019:
1974:
1939:
1931:
1892:
1847:
1837:
1794:
1784:
1741:
1731:
1690:
1663:
1618:
1573:
1504:domain
1471:PLA2G7
1464:PLA2G6
1457:PLA2G5
1411:PLA2G3
1347:autism
1210:mGLUR1
1179:Serine
1121:, and
1015:. The
807:asthma
703:kidney
695:tissue
686:, and
676:venoms
610:, and
433:PDBsum
407:
397:
355:SUPFAM
297:Symbol
230:PubMed
212:Search
198:AmiGO
186:PDBsum
126:ExPASy
114:BRENDA
102:IntEnz
73:EC no.
3738:Dicer
3693:;see
3519:3.1.6
3489:PDE4B
3485:PDE4A
3423:3.1.4
3392:IMPA3
3388:IMPA2
3384:IMPA1
3262:3.1.3
3230:3.1.2
3080:3.1.1
2924:PTGS2
2919:PTGS1
2719:S2CID
2593:S2CID
2319:S2CID
1937:S2CID
1042:, or
1029:amide
1013:ester
867:(cPLA
730:lysis
680:snake
658:(sPLA
638:(iPLA
351:SCOPe
342:SCOP2
162:PRIAM
3656:-31:
3602:-16:
3588:and
3494:PDE5
3480:PDE3
3475:PDE2
3470:PDE1
3362:PTEN
3347:OCRL
3340:PP2A
3289:ALPP
3284:ALPL
3279:ALPI
3073:3.1)
3021:HPGD
2797:PMID
2758:PMID
2711:PMID
2670:ISBN
2638:PMID
2585:PMID
2546:PMID
2501:PMID
2474:1FXF
2449:PMID
2411:PMID
2399:1791
2372:PMID
2311:PMID
2299:1488
2276:PMID
2223:PMID
2184:PMID
2125:PMID
2076:PMID
2027:PMID
1972:PMID
1929:PMID
1890:PMID
1845:PMID
1792:PMID
1739:PMID
1688:ISBN
1661:PMID
1616:PMID
1571:PMID
1512:OC90
1341:and
1215:bFGF
1201:5-HT
1175:MAPK
922:and
875:The
828:and
786:and
746:sPLA
701:and
688:wasp
666:The
549:and
521:and
507:acyl
426:PDBj
422:PDBe
405:ECOD
395:Pfam
379:1g4i
347:1bbc
306:Pfam
279:sPLA
242:NCBI
183:PDBe
138:KEGG
18:PLA2
3811:4/5
2789:doi
2750:doi
2703:doi
2628:doi
2624:272
2577:doi
2536:doi
2493:doi
2470:PDB
2441:doi
2437:101
2403:doi
2362:PMC
2354:doi
2303:doi
2266:PMC
2258:doi
2215:doi
2174:PMC
2164:doi
2115:PMC
2107:doi
2066:PMC
2058:doi
2017:PMC
2007:doi
2003:286
1964:doi
1921:doi
1880:doi
1876:122
1835:PMC
1827:doi
1823:120
1782:PMC
1774:doi
1770:120
1729:PMC
1721:doi
1651:doi
1647:258
1606:doi
1602:272
1561:doi
1557:269
1177:at
1157:in
1141:PLA
1123:Tyr
1119:Leu
1115:Phe
1105:PLA
1082:His
1080:.
813:).
726:fat
684:bee
556:PLA
533:or
458:PLA
413:PDB
218:PMC
174:PDB
3876::
3769:2C
3764:2B
3759:2A
3740::
3731::
3521::
3401::
3390:,
3386:,
3302:)/
3264::
3232::
3201:A2
3196:A1
3082::
3071:EC
3065::
2864:–
2860::
2795:.
2785:11
2783:.
2756:.
2746:71
2744:.
2717:.
2709:.
2699:58
2697:.
2650:^
2636:.
2622:.
2618:.
2591:.
2583:.
2573:38
2571:.
2544:.
2532:12
2530:.
2526:.
2499:.
2489:40
2487:.
2472::
2455:.
2447:.
2435:.
2423:^
2409:.
2397:.
2370:.
2360:.
2350:14
2348:.
2344:.
2317:.
2309:.
2297:.
2274:.
2264:.
2254:88
2252:.
2248:.
2221:.
2211:53
2209:.
2182:.
2172:.
2162:.
2150:.
2146:.
2123:.
2113:.
2103:25
2101:.
2097:.
2074:.
2064:.
2054:52
2052:.
2048:.
2025:.
2015:.
2001:.
1997:.
1970:.
1960:76
1958:.
1935:.
1927:.
1917:12
1915:.
1888:.
1874:.
1870:.
1843:.
1833:.
1821:.
1817:.
1790:.
1780:.
1768:.
1764:.
1737:.
1727:.
1715:.
1711:.
1659:.
1645:.
1641:.
1614:.
1600:.
1596:.
1569:.
1555:.
1551:.
1506::
1490:,
1446:,
1440:,
1434:,
1428:,
1422:,
1400:,
1394:,
1388:,
1382:,
1279:.
1275:,
1271:,
1267:,
1189:.
1117:,
836:.
798:.
743:.
732:.
711:Ca
682:,
614:.
606:,
602:,
588:.
537:,
501:sn
475:,
424:;
420:;
403:/
367:82
353:/
349:/
283:.
200:/
3806:3
3801:2
3796:1
3754:1
3592:)
3505:)
3501:(
3487:/
3463:1
3451:D
3446:C
3425::
3306:/
3298:(
3206:B
3140:/
3069:(
3055:e
3048:t
3041:v
2979:/
2850:e
2843:t
2836:v
2803:.
2791::
2777:2
2764:.
2752::
2738:2
2725:.
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2644:.
2630::
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2507:.
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2131:.
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1993:2
1978:.
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1943:.
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1696:.
1667:.
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1257:2
1249:2
1237:2
1203:2
1194:2
1183:2
1171:2
1163:2
1155:2
1143:2
1127:2
1107:2
1096:2
1067:2
1052:2
1040:a
1037:K
993:2
977:2
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965:2
953:)
951:2
947:2
939:2
889:2
881:2
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869:2
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818:2
803:2
776:2
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678:(
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660:2
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558:2
504:2
489:2
460:2
453:2
281:2
277:2
263:2
59:.
53:2
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20:)
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