255:
232:
129:
154:
520:
506:
261:
160:
513:
4197:
1151:
1260:
Mammalian PLD1 has several domains for activators, inhibitors, and catalysis, which it shares with PLD2. Domains for both activation and inhibition are referred to as the phox homology (PX) and pleckstrin homology (PH) domains. The catalytic domain consists of two HKD regions, so named for three of
1228:. There is evidence that PA is able to assist in negative membrane curvature due to its head group being smaller than in many other lipids. One experiment with PLD1 knockout showed a significant reduction in the number of exocytotic fusion events, implying a strong role in exocytosis.
2381:"Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha"
2679:
Kim Y, Han JM, Park JB, Lee SD, Oh YS, Chung C, et al. (August 1999). "Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites".
1248:
showed that limiting PLD1 led to significantly reduced endocytosis of the B cell receptor. Another experiment showed that knocking out PLD1 may hinder the ability of mice to secrete
2824:"Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity"
2570:
Kim JH, Lee SD, Han JM, Lee TG, Kim Y, Park JB, et al. (July 1998). "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA".
2198:
Kim JH, Lee SD, Han JM, Lee TG, Kim Y, Park JB, et al. (July 1998). "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA".
268:
167:
2327:"Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity"
2650:
Kim JH, Han JM, Lee S, Kim Y, Lee TG, Park JB, et al. (March 1999). "Phospholipase D1 in caveolae: regulation by protein kinase Calpha and caveolin-1".
3023:"Differential tyrosine phosphorylation of phospholipase D isozymes by hydrogen peroxide and the epidermal growth factor in A431 epidermoid carcinoma cells"
1951:"alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells"
1476:
Park SH, Chun YH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD1 to human chromosome band 3q26 by fluorescence in situ hybridization".
90:
828:
809:
3271:
3518:
1458:
1126:
The possibility of PLD1 was first mentioned in 1947 by authors
Hanahan and Chaikoff at Berkeley when describing a carrot enzyme that could "
1440:
4217:
3432:
3533:
3527:
3328:
3078:
1042:
254:
3376:
1524:"Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family"
1294:: the protein PED/PEA15 is often elevated in type II diabetic patients, thus enhancing PLD1 activity, and in turn impairing insulin.
3916:
3487:
3276:
1049:
231:
2980:"Endosomal localization of phospholipase D 1a and 1b is defined by the C-termini of the proteins, and is independent of activity"
2451:"Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization"
1736:
1276:: PA, which is produced in part by PLD1, seems to be involved in the movement of β-amyloid, which could precede amyloidogenesis.
3594:
3482:
1427:
1406:
1189:
3403:
3313:
3266:
2241:
Genth H, Schmidt M, Gerhard R, Aktories K, Just I (February 2003). "Activation of phospholipase D1 by ADP-ribosylated RhoA".
4072:
1423:
1150:
1134:." PLD was first derived in mammals in 1975 by Saito and Kanfer, who noted its activity in rats. PLD was first cloned from
153:
128:
3825:
3766:
4187:
1402:
3870:
3437:
3427:
70:
3830:
3722:
3347:
1856:"Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells"
1303:
267:
166:
3416:
3412:
3408:
3324:
3157:
2537:"Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2"
1181:
4057:
4173:
4160:
4147:
4134:
4121:
4108:
4095:
3678:
3624:
3584:
3543:
3447:
3286:
3254:
3140:
3104:
1188:
stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including
260:
159:
4067:
4021:
3964:
3332:
3181:
3095:
1185:
1162:
873:
78:
3969:
3201:
3071:
1261:
the amino acids that are key in catalysis. These domains are conserved across many organisms. There are two
854:
3757:
3396:
1273:
2789:"Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them"
2077:"Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them"
3990:
3909:
3692:
3589:
3381:
3342:
3206:
3128:
4062:
3875:
3710:
3705:
3638:
3298:
3123:
2822:
Divecha N, Roefs M, Halstead JR, D'Andrea S, Fernandez-Borga M, Oomen L, et al. (October 2000).
2462:
1262:
142:
57:
4026:
3730:
3700:
3504:
3499:
3423:
3359:
3145:
1900:"Regulation of Membrane Turnover by Phosphatidic Acid: Cellular Functions and Disease Implications"
1854:
Tanguy E, Costé de
Bagneaux P, Kassas N, Ammar MR, Wang Q, Haeberlé AM, et al. (August 2020).
1193:
1158:
1002:
976:
968:
943:
2787:
Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, et al. (November 2000).
2075:
Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, et al. (November 2000).
3959:
3863:
3715:
3196:
3186:
3064:
2638:
2595:
2488:
2223:
1781:
1750:
Andersson L, Boström P, Ericson J, Rutberg M, Magnusson B, Marchesan D, et al. (June 2006).
1718:
1522:
Hammond SM, Altshuller YM, Sung TC, Rudge SA, Rose K, Engebrecht J, et al. (December 1995).
1501:
102:
1006:
972:
947:
4222:
3664:
3609:
3577:
3452:
3171:
3044:
3009:
2966:
2931:
2888:
2853:
2810:
2775:
2732:
2697:
2667:
2630:
2587:
2558:
2523:
2480:
2437:
2402:
2356:
2307:
2258:
2215:
2180:
2139:
2098:
2057:
2016:
1972:
1931:
1877:
1833:
1773:
1710:
1656:
1615:
1545:
1493:
1341:
1282:: certain rat tumors with dominant negative PLD do not appear to form new colonies or tumors.
1173:
1139:
50:
2379:
Hammond SM, Jenco JM, Nakashima S, Cadwallader K, Gu Q, Cook S, et al. (February 1997).
4005:
4000:
3974:
3902:
3740:
3320:
3225:
3220:
3176:
3034:
2999:
2991:
2956:
2921:
2913:
2878:
2843:
2835:
2800:
2765:
2757:
2722:
2689:
2659:
2620:
2579:
2548:
2513:
2470:
2427:
2392:
2346:
2338:
2297:
2289:
2250:
2207:
2170:
2129:
2088:
2047:
2006:
1962:
1921:
1911:
1867:
1823:
1815:
1763:
1700:
1692:
1646:
1605:
1597:
1535:
1485:
519:
347:
278:
222:
177:
4052:
4036:
3949:
3842:
3656:
3572:
3567:
3562:
3475:
3470:
3230:
3108:
1311:
1291:
1225:
505:
322:
98:
2449:
Colley WC, Sung TC, Roll R, Jenco J, Hammond SM, Altshuller Y, et al. (March 1997).
2466:
1705:
1680:
4201:
4090:
4031:
3815:
3810:
3805:
3191:
3166:
3162:
3135:
3118:
3004:
2979:
2926:
2901:
2865:
Oishi K, Takahashi M, Mukai H, Banno Y, Nakashima S, Kanaho Y, et al. (May 2001).
2351:
2326:
2325:
Lewis JA, Scott SA, Lavieri R, Buck JR, Selvy PE, Stoops SL, et al. (April 2009).
2302:
2277:
2116:
Oishi K, Takahashi M, Mukai H, Banno Y, Nakashima S, Kanaho Y, et al. (May 2001).
1926:
1899:
1828:
1803:
1610:
1585:
3039:
3022:
2848:
2823:
2583:
2475:
2450:
2254:
2211:
1651:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
586:
581:
571:
566:
561:
512:
4211:
3995:
3954:
3556:
3465:
3215:
2770:
2761:
2745:
1249:
1217:
548:
2642:
2599:
2502:"Determination of interaction sites on the small G protein RhoA for phospholipase D"
2492:
2414:
Luo JQ, Liu X, Hammond SM, Colley WC, Feig LA, Frohman MA, et al. (June 1997).
2227:
2157:
Luo JQ, Liu X, Hammond SM, Colley WC, Feig LA, Frohman MA, et al. (June 1997).
1722:
1505:
3944:
3683:
3614:
3337:
3258:
1785:
1366:
1265:
of the protein, PLD1a and PLD1b, but they do not seem to localize any differently.
1131:
340:
119:
82:
2416:"RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1"
2159:"RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1"
1288:: PLD knockout mice appear to have reduced occlusion, thus offsetting thrombosis.
1872:
1855:
1819:
106:
4168:
4103:
3939:
3858:
3629:
3523:
3386:
3352:
3290:
3056:
2995:
2609:"Characterization of human PLD2 and the analysis of PLD isoform splice variants"
1463:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1445:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1317:
1237:
1197:
4196:
2839:
2342:
423:
3835:
2625:
2608:
1696:
1285:
1241:
1169:
1118:, though analogues are found in plants, fungi, prokaryotes, and even viruses.
239:
136:
86:
2553:
2536:
2518:
2501:
1916:
1540:
1523:
4142:
4116:
3748:
3547:
3460:
3087:
1949:
Ahn BH, Rhim H, Kim SY, Sung YM, Lee MY, Choi JY, et al. (April 2002).
1252:, molecules that are essential for vesicular communication across the body.
1205:
773:
483:
361:
306:
293:
205:
192:
94:
3048:
3013:
2970:
2961:
2944:
2935:
2892:
2883:
2866:
2857:
2814:
2805:
2788:
2779:
2746:"Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts"
2736:
2727:
2710:
2701:
2671:
2432:
2415:
2397:
2380:
2360:
2311:
2262:
2175:
2158:
2143:
2134:
2117:
2102:
2093:
2076:
2061:
2052:
2035:
2020:
2011:
1994:
1976:
1967:
1950:
1935:
1881:
1837:
1777:
1714:
1660:
1619:
2634:
2591:
2562:
2527:
2484:
2441:
2406:
2219:
2184:
1808:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
1549:
1497:
1089:
1084:
3793:
3788:
3783:
3604:
3239:
3091:
2943:
Lee S, Park JB, Kim JH, Kim Y, Kim JH, Shin KJ, et al. (July 2001).
1221:
1073:
918:
899:
2945:"Actin directly interacts with phospholipase D, inhibiting its activity"
2711:"Activation of phospholipase D1 by Cdc42 requires the Rho insert region"
2663:
2036:"Activation of phospholipase D1 by Cdc42 requires the Rho insert region"
576:
3800:
3778:
3773:
3391:
1993:
Lee C, Kim SR, Chung JK, Frohman MA, Kilimann MW, Rhee SG (June 2000).
1634:
1201:
1177:
1165:
1127:
885:
840:
2917:
2693:
2293:
1768:
1751:
1601:
1489:
4155:
3925:
3820:
3753:
3646:
3244:
3152:
1586:"Phospholipase D: enzymology, functionality, and chemical modulation"
1279:
1245:
1108:
1057:
795:
2744:
Suzuki J, Yamazaki Y, Li G, Kaziro Y, Koide H, Guang L (July 2000).
17:
1142:
in 1995, while mammalian PLD1 was first cloned from a rat in 1997.
4129:
3762:
3513:
3509:
1737:"Entrez Gene: PLD1 phospholipase D1, phosphatidylcholine-specific"
1335:
1329:
1149:
2902:"Determination of interaction sites of phospholipase D1 for RhoA"
2278:"Determination of interaction sites of phospholipase D1 for RhoA"
1804:"Phospholipase D in endocytosis and endosomal recycling pathways"
758:
754:
3494:
3371:
3364:
3308:
3303:
1373:
1352:
1346:
1323:
1135:
1115:
567:
N-acylphosphatidylethanolamine-specific phospholipase D activity
74:
3898:
3060:
528:
1584:
Selvy PE, Lavieri RR, Lindsley CW, Brown HA (October 2011).
2867:"PKN regulates phospholipase D1 through direct interaction"
2118:"PKN regulates phospholipase D1 through direct interaction"
3894:
1752:"PLD1 and ERK2 regulate cytosolic lipid droplet formation"
2607:
Steed PM, Clark KL, Boyar WC, Lasala DJ (October 1998).
330:
1244:
of signaling molecules. For example, one experiment in
4185:
495:
4081:
4045:
4014:
3983:
3932:
3851:
3739:
3691:
3677:
3655:
3637:
3623:
3603:
3542:
3446:
3285:
3253:
3103:
2709:Walker SJ, Wu WJ, Cerione RA, Brown HA (May 2000).
2420:
2243:
2163:
2034:Walker SJ, Wu WJ, Cerione RA, Brown HA (May 2000).
1154:
Site of hydrolysis on a phosphatidylcholine by PLD1
1020:
995:
961:
936:
1419:
1417:
1415:
1398:
1396:
1394:
1208:, and the creation of cytoplasmic lipid droplets.
3382:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
2500:Bae CD, Min DS, Fleming IN, Exton JH (May 1998).
1898:Thakur R, Naik A, Panda A, Raghu P (2019-06-04).
1635:"The phosphorus-containing lipides of the carrot"
277:
176:
1995:"Inhibition of phospholipase D by amphiphysins"
1988:
1986:
29:Protein-coding gene in the species Homo sapiens
1424:GRCm38: Ensembl release 89: ENSMUSG00000027695
3910:
3072:
1517:
1515:
8:
2331:Bioorganic & Medicinal Chemistry Letters
2535:Lopez I, Arnold RS, Lambeth JD (May 1998).
1904:Frontiers in Cell and Developmental Biology
1403:GRCh38: Ensembl release 89: ENSG00000075651
3917:
3903:
3895:
3688:
3634:
3620:
3079:
3065:
3057:
1236:PLD1 may play a role in some cells in the
769:
544:
318:
217:
114:
3038:
3003:
2960:
2925:
2882:
2847:
2804:
2769:
2726:
2624:
2552:
2517:
2474:
2431:
2396:
2350:
2301:
2174:
2133:
2092:
2051:
2010:
1966:
1925:
1915:
1871:
1827:
1767:
1704:
1681:"Phospholipase D: a lipid centric review"
1650:
1609:
1539:
709:small GTPase mediated signal transduction
1372:VU-0359595: 1,700-fold selective versus
1216:PLD1 has been shown to associate at the
4192:
3272:Ubiquitin carboxy-terminal hydrolase L1
1679:Jenkins GM, Frohman MA (October 2005).
1390:
1633:Hanahan DJ, Chaikoff IL (April 1947).
1161:(PC)-specific phospholipases D (PLDs)
734:phosphatidic acid biosynthetic process
446:crypt of lieberkuhn of small intestine
31:
3852:either deoxy- or ribo-
1893:
1891:
1849:
1847:
1797:
1795:
1579:
282:
243:
238:
181:
140:
135:
7:
3433:Protein serine/threonine phosphatase
1685:Cellular and Molecular Life Sciences
1674:
1672:
1670:
1577:
1575:
1573:
1571:
1569:
1567:
1565:
1563:
1561:
1559:
744:regulation of synaptic vesicle cycle
462:vestibular membrane of cochlear duct
3534:Cyclic nucleotide phosphodiesterase
3528:Clostridium perfringens alpha toxin
3329:Tartrate-resistant acid phosphatase
3021:Min DS, Ahn BH, Jo YH (June 2001).
2949:The Journal of Biological Chemistry
2871:The Journal of Biological Chemistry
2793:The Journal of Biological Chemistry
2715:The Journal of Biological Chemistry
2541:The Journal of Biological Chemistry
2506:The Journal of Biological Chemistry
2385:The Journal of Biological Chemistry
2122:The Journal of Biological Chemistry
2081:The Journal of Biological Chemistry
2040:The Journal of Biological Chemistry
1999:The Journal of Biological Chemistry
1955:The Journal of Biological Chemistry
1639:The Journal of Biological Chemistry
1528:The Journal of Biological Chemistry
1302:Phospholipase D1 has been shown to
3377:Pyruvate dehydrogenase phosphatase
2978:Hughes WE, Parker PJ (June 2001).
1017:
992:
958:
933:
909:
890:
864:
845:
819:
800:
694:regulation of microvillus assembly
500:
418:
356:
335:
25:
3277:4-hydroxybenzoyl-CoA thioesterase
1111:that in humans is encoded by the
739:inositol lipid-mediated signaling
4195:
2762:10.1128/MCB.20.13.4658-4665.2000
518:
511:
504:
266:
259:
253:
230:
165:
158:
152:
127:
3595:N-acetylglucosamine-6-sulfatase
3483:Sphingomyelin phosphodiesterase
1802:Donaldson JG (September 2009).
724:Ras protein signal transduction
638:perinuclear region of cytoplasm
3404:Inositol-phosphate phosphatase
3267:Palmitoyl protein thioesterase
2750:Molecular and Cellular Biology
1478:Cytogenetics and Cell Genetics
648:endoplasmic reticulum membrane
529:More reference expression data
484:More reference expression data
1:
3767:RNA-induced silencing complex
3040:10.1016/S1016-8478(23)17049-X
2584:10.1016/S0014-5793(98)00661-9
2476:10.1016/S0960-9822(97)70090-3
2255:10.1016/s0006-291x(03)00112-8
2212:10.1016/s0014-5793(98)00661-9
1652:10.1016/S0021-9258(17)35110-4
1176:(PA) and choline. A range of
251:
150:
3871:Serratia marcescens nuclease
3438:Dual-specificity phosphatase
3428:Protein tyrosine phosphatase
2900:Cai S, Exton JH (May 2001).
2276:Cai S, Exton JH (May 2001).
1873:10.1016/j.celrep.2020.108026
1820:10.1016/j.bbalip.2009.05.011
582:phosphatidylinositol binding
4218:Genes on human chromosome 3
3348:Fructose 1,6-bisphosphatase
1182:G protein-coupled receptors
4239:
2343:10.1016/j.bmcl.2009.02.057
1240:of signaling receptors or
1224:, early endosome, and the
4073:Michaelis–Menten kinetics
3585:Galactosamine-6 sulfatase
3141:6-phosphogluconolactonase
2996:10.1042/0264-6021:3560727
2626:10.1096/fasebj.12.13.1309
1697:10.1007/s00018-005-5195-z
1459:"Mouse PubMed Reference:"
1441:"Human PubMed Reference:"
1186:receptor tyrosine kinases
1088:
1083:
1079:
1072:
1056:
1037:
1024:
999:
988:
965:
940:
929:
916:
912:
897:
893:
884:
871:
867:
852:
848:
839:
826:
822:
807:
803:
794:
779:
772:
768:
752:
673:tertiary granule membrane
668:specific granule membrane
547:
543:
526:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
3965:Diffusion-limited enzyme
3333:Purple acid phosphatases
2840:10.1093/emboj/19.20.5440
2554:10.1074/jbc.273.21.12846
2519:10.1074/jbc.273.19.11596
1917:10.3389/fcell.2019.00083
1541:10.1074/jbc.270.50.29640
1043:Chr 3: 171.6 – 171.81 Mb
729:neutrophil degranulation
562:phospholipase D activity
61:, phospholipase D1, CVDD
2984:The Biochemical Journal
2906:The Biochemical Journal
2282:The Biochemical Journal
1756:Journal of Cell Science
1050:Chr 3: 27.99 – 28.19 Mb
714:lipid catabolic process
3758:Microprocessor complex
3397:Beta-propeller phytase
2962:10.1074/jbc.M008521200
2884:10.1074/jbc.M010646200
2806:10.1074/jbc.M003329200
2728:10.1074/jbc.M000076200
2433:10.1006/bbrc.1997.6793
2398:10.1074/jbc.272.6.3860
2176:10.1006/bbrc.1997.6793
2135:10.1074/jbc.M010646200
2094:10.1074/jbc.M003329200
2053:10.1074/jbc.M000076200
2012:10.1074/jbc.M001695200
1968:10.1074/jbc.M110414200
1155:
628:apical plasma membrane
608:late endosome membrane
4058:Eadie–Hofstee diagram
3991:Allosteric regulation
3693:Endodeoxyribonuclease
3590:Iduronate-2-sulfatase
3343:Glucose 6-phosphatase
3129:Butyrylcholinesterase
1153:
633:endoplasmic reticulum
4068:Lineweaver–Burk plot
3876:Micrococcal nuclease
3711:Deoxyribonuclease IV
3706:Deoxyribonuclease II
3639:Exodeoxyribonuclease
3299:Alkaline phosphatase
3124:Acetylcholinesterase
1212:Membrane trafficking
1198:platelet coagulation
1190:membrane trafficking
376:right adrenal cortex
284:3 A3|3 11.15 cM
245:Chromosome 3 (mouse)
143:Chromosome 3 (human)
3731:UvrABC endonuclease
3701:Deoxyribonuclease I
3424:Protein phosphatase
3360:Protein phosphatase
3158:Bile salt-dependent
3146:PAF acetylhydrolase
3027:Molecules and Cells
2467:1997CBio....7..191C
1274:Alzheimer's disease
1232:Signal transduction
1194:signal transduction
1159:Phosphatidylcholine
678:cholinergic synapse
396:left adrenal cortex
380:mucosa of esophagus
4027:Enzyme superfamily
3960:Enzyme promiscuity
3864:Mung bean nuclease
3723:Restriction enzyme
3716:Restriction enzyme
1762:(Pt 11): 2246–57.
1691:(19–20): 2305–16.
1156:
874:ENSMUSG00000027695
687:Biological process
623:lysosomal membrane
596:Cellular component
587:hydrolase activity
577:catalytic activity
555:Molecular function
466:epithelium of lens
388:left adrenal gland
4183:
4182:
3892:
3891:
3888:
3887:
3884:
3883:
3673:
3672:
3665:Oligonucleotidase
3610:deoxyribonuclease
3578:Steroid sulfatase
3453:Phosphodiesterase
3182:Hormone-sensitive
2918:10.1042/bj3550779
2877:(21): 18096–101.
2694:10.1021/bi990579h
2664:10.1021/bi982478+
2512:(19): 11596–604.
2294:10.1042/bj3550779
2128:(21): 18096–101.
1769:10.1242/jcs.02941
1602:10.1021/cr200296t
1490:10.1159/000015105
1342:Protein kinase N1
1174:phosphatidic acid
1172:of PC to produce
1099:
1098:
1095:
1094:
1068:
1067:
1033:
1032:
1014:
1013:
984:
983:
955:
954:
925:
924:
906:
905:
880:
879:
861:
860:
835:
834:
816:
815:
764:
763:
618:endocytic vesicle
539:
538:
535:
534:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
16:(Redirected from
4230:
4200:
4199:
4191:
4063:Hanes–Woolf plot
4006:Enzyme activator
4001:Enzyme inhibitor
3975:Enzyme catalysis
3919:
3912:
3905:
3896:
3741:Endoribonuclease
3727:
3721:
3689:
3635:
3621:
3321:Acid phosphatase
3202:Monoacylglycerol
3112:ester hydrolases
3081:
3074:
3067:
3058:
3052:
3042:
3017:
3007:
2990:(Pt 3): 727–36.
2974:
2964:
2955:(30): 28252–60.
2939:
2929:
2912:(Pt 3): 779–85.
2896:
2886:
2861:
2851:
2828:The EMBO Journal
2818:
2808:
2799:(45): 35224–32.
2783:
2773:
2740:
2730:
2705:
2688:(32): 10344–51.
2675:
2646:
2628:
2603:
2566:
2556:
2547:(21): 12846–52.
2531:
2521:
2496:
2478:
2445:
2435:
2410:
2400:
2365:
2364:
2354:
2322:
2316:
2315:
2305:
2288:(Pt 3): 779–85.
2273:
2267:
2266:
2238:
2232:
2231:
2195:
2189:
2188:
2178:
2154:
2148:
2147:
2137:
2113:
2107:
2106:
2096:
2087:(45): 35224–32.
2072:
2066:
2065:
2055:
2031:
2025:
2024:
2014:
1990:
1981:
1980:
1970:
1961:(14): 12334–42.
1946:
1940:
1939:
1929:
1919:
1895:
1886:
1885:
1875:
1851:
1842:
1841:
1831:
1799:
1790:
1789:
1771:
1747:
1741:
1740:
1733:
1727:
1726:
1708:
1676:
1665:
1664:
1654:
1630:
1624:
1623:
1613:
1596:(10): 6064–119.
1590:Chemical Reviews
1581:
1554:
1553:
1543:
1519:
1510:
1509:
1473:
1467:
1466:
1455:
1449:
1448:
1437:
1431:
1421:
1410:
1400:
1374:phospholipase D2
1292:Type II Diabetes
1081:
1080:
1052:
1045:
1028:
1018:
1009:
993:
989:RefSeq (protein)
979:
959:
950:
934:
910:
891:
865:
846:
820:
801:
770:
699:lipid metabolism
545:
531:
522:
515:
508:
501:
486:
438:secondary oocyte
426:
424:Top expressed in
419:
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
107:PLD1 - orthologs
60:
53:
32:
21:
4238:
4237:
4233:
4232:
4231:
4229:
4228:
4227:
4208:
4207:
4206:
4194:
4186:
4184:
4179:
4091:Oxidoreductases
4077:
4053:Enzyme kinetics
4041:
4037:List of enzymes
4010:
3979:
3950:Catalytic triad
3928:
3923:
3893:
3880:
3847:
3735:
3725:
3719:
3682:
3669:
3657:Exoribonuclease
3651:
3628:
3612:
3608:
3599:
3573:Arylsulfatase L
3568:Arylsulfatase B
3563:Arylsulfatase A
3538:
3451:
3442:
3281:
3249:
3111:
3099:
3085:
3055:
3020:
2977:
2942:
2899:
2864:
2821:
2786:
2756:(13): 4658–65.
2743:
2721:(21): 15665–8.
2708:
2678:
2649:
2619:(13): 1309–17.
2606:
2569:
2534:
2499:
2455:Current Biology
2448:
2413:
2378:
2374:
2372:Further reading
2369:
2368:
2324:
2323:
2319:
2275:
2274:
2270:
2240:
2239:
2235:
2197:
2196:
2192:
2156:
2155:
2151:
2115:
2114:
2110:
2074:
2073:
2069:
2046:(21): 15665–8.
2033:
2032:
2028:
2005:(25): 18751–8.
1992:
1991:
1984:
1948:
1947:
1943:
1897:
1896:
1889:
1853:
1852:
1845:
1801:
1800:
1793:
1749:
1748:
1744:
1735:
1734:
1730:
1678:
1677:
1668:
1632:
1631:
1627:
1583:
1582:
1557:
1534:(50): 29640–3.
1521:
1520:
1513:
1475:
1474:
1470:
1457:
1456:
1452:
1439:
1438:
1434:
1422:
1413:
1401:
1392:
1387:
1379:
1363:
1358:
1312:Alpha-synuclein
1300:
1271:
1263:splice variants
1258:
1234:
1226:Golgi apparatus
1218:plasma membrane
1214:
1180:acting through
1148:
1124:
1105:
1102:Phospholipase D
1090:View/Edit Mouse
1085:View/Edit Human
1048:
1041:
1038:Location (UCSC)
1026:
1005:
1001:
975:
971:
967:
946:
942:
855:ENSG00000075651
748:
682:
663:plasma membrane
658:Golgi apparatus
591:
572:protein binding
527:
517:
516:
510:
509:
482:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
411:
406:
402:
400:skin of abdomen
398:
394:
392:corpus callosum
390:
386:
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
30:
23:
22:
15:
12:
11:
5:
4236:
4234:
4226:
4225:
4220:
4210:
4209:
4205:
4204:
4181:
4180:
4178:
4177:
4164:
4151:
4138:
4125:
4112:
4099:
4085:
4083:
4079:
4078:
4076:
4075:
4070:
4065:
4060:
4055:
4049:
4047:
4043:
4042:
4040:
4039:
4034:
4029:
4024:
4018:
4016:
4015:Classification
4012:
4011:
4009:
4008:
4003:
3998:
3993:
3987:
3985:
3981:
3980:
3978:
3977:
3972:
3967:
3962:
3957:
3952:
3947:
3942:
3936:
3934:
3930:
3929:
3924:
3922:
3921:
3914:
3907:
3899:
3890:
3889:
3886:
3885:
3882:
3881:
3879:
3878:
3873:
3868:
3867:
3866:
3855:
3853:
3849:
3848:
3846:
3845:
3840:
3839:
3838:
3833:
3828:
3823:
3813:
3808:
3803:
3798:
3797:
3796:
3791:
3786:
3781:
3771:
3770:
3769:
3760:
3745:
3743:
3737:
3736:
3734:
3733:
3728:
3713:
3708:
3703:
3697:
3695:
3686:
3675:
3674:
3671:
3670:
3668:
3667:
3661:
3659:
3653:
3652:
3650:
3649:
3643:
3641:
3632:
3618:
3601:
3600:
3598:
3597:
3592:
3587:
3582:
3581:
3580:
3575:
3570:
3565:
3552:
3550:
3540:
3539:
3537:
3536:
3531:
3521:
3516:
3507:
3502:
3497:
3492:
3491:
3490:
3480:
3479:
3478:
3473:
3463:
3457:
3455:
3444:
3443:
3441:
3440:
3435:
3430:
3421:
3420:
3419:
3401:
3400:
3399:
3389:
3384:
3379:
3374:
3369:
3368:
3367:
3357:
3356:
3355:
3345:
3340:
3335:
3318:
3317:
3316:
3311:
3306:
3295:
3293:
3283:
3282:
3280:
3279:
3274:
3269:
3263:
3261:
3251:
3250:
3248:
3247:
3242:
3236:
3235:
3234:
3233:
3228:
3223:
3212:
3211:
3210:
3209:
3207:Diacylglycerol
3204:
3199:
3194:
3189:
3184:
3179:
3174:
3169:
3160:
3149:
3148:
3143:
3138:
3136:Pectinesterase
3133:
3132:
3131:
3126:
3119:Cholinesterase
3115:
3113:
3101:
3100:
3086:
3084:
3083:
3076:
3069:
3061:
3054:
3053:
3018:
2975:
2940:
2897:
2862:
2834:(20): 5440–9.
2819:
2784:
2741:
2706:
2676:
2658:(12): 3763–9.
2647:
2604:
2567:
2532:
2497:
2461:(3): 191–201.
2446:
2411:
2375:
2373:
2370:
2367:
2366:
2337:(7): 1916–20.
2317:
2268:
2233:
2190:
2149:
2108:
2067:
2026:
1982:
1941:
1887:
1843:
1791:
1742:
1728:
1666:
1625:
1555:
1511:
1468:
1450:
1432:
1411:
1389:
1388:
1386:
1383:
1382:
1381:
1377:
1370:
1369:, an inhibitor
1362:
1359:
1357:
1356:
1350:
1344:
1339:
1333:
1327:
1321:
1315:
1308:
1299:
1296:
1270:
1267:
1257:
1254:
1250:catecholamines
1233:
1230:
1213:
1210:
1147:
1144:
1123:
1120:
1103:
1097:
1096:
1093:
1092:
1087:
1077:
1076:
1070:
1069:
1066:
1065:
1063:
1061:
1054:
1053:
1046:
1039:
1035:
1034:
1031:
1030:
1022:
1021:
1015:
1012:
1011:
997:
996:
990:
986:
985:
982:
981:
963:
962:
956:
953:
952:
938:
937:
931:
927:
926:
923:
922:
914:
913:
907:
904:
903:
895:
894:
888:
882:
881:
878:
877:
869:
868:
862:
859:
858:
850:
849:
843:
837:
836:
833:
832:
824:
823:
817:
814:
813:
805:
804:
798:
792:
791:
786:
781:
777:
776:
766:
765:
762:
761:
750:
749:
747:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
690:
688:
684:
683:
681:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
613:Golgi membrane
610:
605:
599:
597:
593:
592:
590:
589:
584:
579:
574:
569:
564:
558:
556:
552:
551:
541:
540:
537:
536:
533:
532:
524:
523:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
442:primary oocyte
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
408:jejunal mucosa
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4235:
4224:
4221:
4219:
4216:
4215:
4213:
4203:
4198:
4193:
4189:
4175:
4171:
4170:
4165:
4162:
4158:
4157:
4152:
4149:
4145:
4144:
4139:
4136:
4132:
4131:
4126:
4123:
4119:
4118:
4113:
4110:
4106:
4105:
4100:
4097:
4093:
4092:
4087:
4086:
4084:
4080:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4050:
4048:
4044:
4038:
4035:
4033:
4032:Enzyme family
4030:
4028:
4025:
4023:
4020:
4019:
4017:
4013:
4007:
4004:
4002:
3999:
3997:
3996:Cooperativity
3994:
3992:
3989:
3988:
3986:
3982:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3955:Oxyanion hole
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3937:
3935:
3931:
3927:
3920:
3915:
3913:
3908:
3906:
3901:
3900:
3897:
3877:
3874:
3872:
3869:
3865:
3862:
3861:
3860:
3857:
3856:
3854:
3850:
3844:
3841:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3818:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3776:
3775:
3772:
3768:
3764:
3761:
3759:
3755:
3752:
3751:
3750:
3747:
3746:
3744:
3742:
3738:
3732:
3729:
3724:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3698:
3696:
3694:
3690:
3687:
3685:
3680:
3676:
3666:
3663:
3662:
3660:
3658:
3654:
3648:
3645:
3644:
3642:
3640:
3636:
3633:
3631:
3626:
3622:
3619:
3616:
3611:
3606:
3602:
3596:
3593:
3591:
3588:
3586:
3583:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3560:
3559:
3558:
3557:arylsulfatase
3554:
3553:
3551:
3549:
3545:
3541:
3535:
3532:
3529:
3525:
3522:
3520:
3517:
3515:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3489:
3486:
3485:
3484:
3481:
3477:
3474:
3472:
3469:
3468:
3467:
3466:Phospholipase
3464:
3462:
3459:
3458:
3456:
3454:
3449:
3445:
3439:
3436:
3434:
3431:
3429:
3425:
3422:
3418:
3414:
3410:
3407:
3406:
3405:
3402:
3398:
3395:
3394:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3366:
3363:
3362:
3361:
3358:
3354:
3351:
3350:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3330:
3326:
3322:
3319:
3315:
3312:
3310:
3307:
3305:
3302:
3301:
3300:
3297:
3296:
3294:
3292:
3288:
3284:
3278:
3275:
3273:
3270:
3268:
3265:
3264:
3262:
3260:
3256:
3252:
3246:
3243:
3241:
3238:
3237:
3232:
3229:
3227:
3224:
3222:
3219:
3218:
3217:
3216:Phospholipase
3214:
3213:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3164:
3161:
3159:
3156:
3155:
3154:
3151:
3150:
3147:
3144:
3142:
3139:
3137:
3134:
3130:
3127:
3125:
3122:
3121:
3120:
3117:
3116:
3114:
3110:
3106:
3102:
3097:
3093:
3089:
3082:
3077:
3075:
3070:
3068:
3063:
3062:
3059:
3050:
3046:
3041:
3036:
3033:(3): 369–78.
3032:
3028:
3024:
3019:
3015:
3011:
3006:
3001:
2997:
2993:
2989:
2985:
2981:
2976:
2972:
2968:
2963:
2958:
2954:
2950:
2946:
2941:
2937:
2933:
2928:
2923:
2919:
2915:
2911:
2907:
2903:
2898:
2894:
2890:
2885:
2880:
2876:
2872:
2868:
2863:
2859:
2855:
2850:
2845:
2841:
2837:
2833:
2829:
2825:
2820:
2816:
2812:
2807:
2802:
2798:
2794:
2790:
2785:
2781:
2777:
2772:
2767:
2763:
2759:
2755:
2751:
2747:
2742:
2738:
2734:
2729:
2724:
2720:
2716:
2712:
2707:
2703:
2699:
2695:
2691:
2687:
2683:
2677:
2673:
2669:
2665:
2661:
2657:
2653:
2648:
2644:
2640:
2636:
2632:
2627:
2622:
2618:
2614:
2613:FASEB Journal
2610:
2605:
2601:
2597:
2593:
2589:
2585:
2581:
2577:
2573:
2568:
2564:
2560:
2555:
2550:
2546:
2542:
2538:
2533:
2529:
2525:
2520:
2515:
2511:
2507:
2503:
2498:
2494:
2490:
2486:
2482:
2477:
2472:
2468:
2464:
2460:
2456:
2452:
2447:
2443:
2439:
2434:
2429:
2425:
2421:
2417:
2412:
2408:
2404:
2399:
2394:
2391:(6): 3860–8.
2390:
2386:
2382:
2377:
2376:
2371:
2362:
2358:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2321:
2318:
2313:
2309:
2304:
2299:
2295:
2291:
2287:
2283:
2279:
2272:
2269:
2264:
2260:
2256:
2252:
2249:(1): 127–32.
2248:
2244:
2237:
2234:
2229:
2225:
2221:
2217:
2213:
2209:
2205:
2201:
2194:
2191:
2186:
2182:
2177:
2172:
2168:
2164:
2160:
2153:
2150:
2145:
2141:
2136:
2131:
2127:
2123:
2119:
2112:
2109:
2104:
2100:
2095:
2090:
2086:
2082:
2078:
2071:
2068:
2063:
2059:
2054:
2049:
2045:
2041:
2037:
2030:
2027:
2022:
2018:
2013:
2008:
2004:
2000:
1996:
1989:
1987:
1983:
1978:
1974:
1969:
1964:
1960:
1956:
1952:
1945:
1942:
1937:
1933:
1928:
1923:
1918:
1913:
1909:
1905:
1901:
1894:
1892:
1888:
1883:
1879:
1874:
1869:
1866:(7): 108026.
1865:
1861:
1857:
1850:
1848:
1844:
1839:
1835:
1830:
1825:
1821:
1817:
1813:
1809:
1805:
1798:
1796:
1792:
1787:
1783:
1779:
1775:
1770:
1765:
1761:
1757:
1753:
1746:
1743:
1738:
1732:
1729:
1724:
1720:
1716:
1712:
1707:
1702:
1698:
1694:
1690:
1686:
1682:
1675:
1673:
1671:
1667:
1662:
1658:
1653:
1648:
1645:(1): 233–40.
1644:
1640:
1636:
1629:
1626:
1621:
1617:
1612:
1607:
1603:
1599:
1595:
1591:
1587:
1580:
1578:
1576:
1574:
1572:
1570:
1568:
1566:
1564:
1562:
1560:
1556:
1551:
1547:
1542:
1537:
1533:
1529:
1525:
1518:
1516:
1512:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1472:
1469:
1464:
1460:
1454:
1451:
1446:
1442:
1436:
1433:
1429:
1425:
1420:
1418:
1416:
1412:
1408:
1404:
1399:
1397:
1395:
1391:
1384:
1375:
1371:
1368:
1365:
1364:
1360:
1354:
1351:
1348:
1345:
1343:
1340:
1337:
1334:
1331:
1328:
1325:
1322:
1319:
1316:
1313:
1310:
1309:
1307:
1305:
1297:
1295:
1293:
1289:
1287:
1283:
1281:
1277:
1275:
1268:
1266:
1264:
1255:
1253:
1251:
1247:
1243:
1239:
1231:
1229:
1227:
1223:
1219:
1211:
1209:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1179:
1175:
1171:
1168:catalyze the
1167:
1164:
1160:
1152:
1145:
1143:
1141:
1137:
1133:
1132:phospholipids
1129:
1121:
1119:
1117:
1114:
1110:
1107:(PLD1) is an
1106:
1091:
1086:
1082:
1078:
1075:
1071:
1064:
1062:
1059:
1055:
1051:
1047:
1044:
1040:
1036:
1029:
1023:
1019:
1016:
1010:
1008:
1004:
998:
994:
991:
987:
980:
978:
974:
970:
964:
960:
957:
951:
949:
945:
939:
935:
932:
930:RefSeq (mRNA)
928:
921:
920:
915:
911:
908:
902:
901:
896:
892:
889:
887:
883:
876:
875:
870:
866:
863:
857:
856:
851:
847:
844:
842:
838:
831:
830:
825:
821:
818:
812:
811:
806:
802:
799:
797:
793:
790:
787:
785:
782:
778:
775:
771:
767:
760:
756:
751:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
704:cell motility
702:
700:
697:
695:
692:
691:
689:
686:
685:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
600:
598:
595:
594:
588:
585:
583:
580:
578:
575:
573:
570:
568:
565:
563:
560:
559:
557:
554:
553:
550:
549:Gene ontology
546:
542:
530:
525:
521:
514:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
27:
19:
4169:Translocases
4166:
4153:
4140:
4127:
4114:
4104:Transferases
4101:
4088:
3945:Binding site
3726:}}
3720:{{
3684:Endonuclease
3615:ribonuclease
3555:
3338:Nucleotidase
3259:Thioesterase
3030:
3026:
2987:
2983:
2952:
2948:
2909:
2905:
2874:
2870:
2831:
2827:
2796:
2792:
2753:
2749:
2718:
2714:
2685:
2682:Biochemistry
2681:
2655:
2652:Biochemistry
2651:
2616:
2612:
2578:(3): 231–5.
2575:
2572:FEBS Letters
2571:
2544:
2540:
2509:
2505:
2458:
2454:
2426:(3): 854–9.
2423:
2419:
2388:
2384:
2334:
2330:
2320:
2285:
2281:
2271:
2246:
2242:
2236:
2206:(3): 231–5.
2203:
2200:FEBS Letters
2199:
2193:
2169:(3): 854–9.
2166:
2162:
2152:
2125:
2121:
2111:
2084:
2080:
2070:
2043:
2039:
2029:
2002:
1998:
1958:
1954:
1944:
1907:
1903:
1863:
1860:Cell Reports
1859:
1814:(9): 845–9.
1811:
1807:
1759:
1755:
1745:
1731:
1688:
1684:
1642:
1638:
1628:
1593:
1589:
1531:
1527:
1484:(3–4): 224.
1481:
1477:
1471:
1462:
1453:
1444:
1435:
1367:Calphostin-c
1301:
1298:Interactions
1290:
1284:
1278:
1272:
1269:Applications
1259:
1235:
1215:
1157:
1125:
1112:
1101:
1100:
1025:
1003:NP_001123553
1000:
977:NM_001368667
969:NM_001164056
966:
944:NM_001130081
941:
917:
898:
872:
853:
827:
808:
788:
783:
346:
339:
204:171,810,950
191:171,600,404
66:External IDs
26:
3940:Active site
3859:Nuclease S1
3630:Exonuclease
3524:Lecithinase
3353:Calcineurin
3291:Phosphatase
3197:Lipoprotein
3187:Endothelial
1318:Amphiphysin
1238:endocytosis
470:Paneth cell
404:skin of leg
372:gallbladder
305:28,187,511
292:27,992,844
44:Identifiers
4212:Categories
4143:Isomerases
4117:Hydrolases
3984:Regulation
3172:Pancreatic
3109:Carboxylic
1430:, May 2017
1409:, May 2017
1385:References
1361:Inhibitors
1286:Thrombosis
1242:exocytosis
1170:hydrolysis
719:chemotaxis
458:left colon
350:(ortholog)
87:HomoloGene
4022:EC number
3749:RNase III
3607:(includes
3548:Sulfatase
3461:Autotaxin
3325:Prostatic
3177:Lysosomal
3092:esterases
3088:Hydrolase
1256:Structure
1206:apoptosis
1007:NP_002653
973:NM_008875
948:NM_002662
774:Orthologs
603:cytoplasm
95:GeneCards
4223:EC 3.1.4
4046:Kinetics
3970:Cofactor
3933:Activity
3843:RNase T1
3605:Nuclease
3240:Cutinase
3049:11459228
3014:11389680
2971:11373276
2936:11311142
2893:11259428
2858:11032811
2815:10926929
2780:10848592
2737:10747870
2702:10441128
2672:10090765
2643:27394831
2600:36075513
2493:14008613
2361:19268584
2312:11311142
2263:12593858
2228:36075513
2144:11259428
2103:10926929
2062:10747870
2021:10764771
1977:11821392
1936:31231646
1882:32814056
1838:19540357
1778:16723731
1723:26447185
1715:16143829
1706:11139095
1661:20291081
1620:21936578
1506:46791637
1426:–
1405:–
1380:= 3.7nM.
1304:interact
1222:endosome
1178:agonists
1146:Function
1074:Wikidata
753:Sources:
653:membrane
643:endosome
384:duodenum
4202:Biology
4156:Ligases
3926:Enzymes
3816:RNase E
3811:RNase Z
3806:RNase A
3801:RNase P
3774:RNase H
3392:Phytase
3192:Hepatic
3167:Lingual
3163:Gastric
3005:1221899
2927:1221795
2635:9761774
2592:9688545
2563:9582313
2528:9565577
2485:9395408
2463:Bibcode
2442:9207251
2407:9013646
2352:3791604
2303:1221795
2220:9688545
2185:9207251
1927:6559011
1829:2731818
1786:1628874
1611:3233269
1550:8530346
1498:9858822
1428:Ensembl
1407:Ensembl
1246:B cells
1220:, late
1202:mitosis
1166:3.1.4.4
1128:choline
1122:History
886:UniProt
841:Ensembl
780:Species
759:QuickGO
450:jejunum
325:pattern
183:3q26.31
51:Aliases
4188:Portal
4130:Lyases
3754:Drosha
3679:3.1.21
3647:RecBCD
3625:3.1.11
3245:PETase
3153:Lipase
3047:
3012:
3002:
2969:
2934:
2924:
2891:
2856:
2849:314009
2846:
2813:
2778:
2768:
2735:
2700:
2670:
2641:
2633:
2598:
2590:
2561:
2526:
2491:
2483:
2440:
2405:
2359:
2349:
2310:
2300:
2261:
2226:
2218:
2183:
2142:
2101:
2060:
2019:
1975:
1934:
1924:
1910:: 83.
1880:
1836:
1826:
1784:
1776:
1721:
1713:
1703:
1659:
1618:
1608:
1548:
1504:
1496:
1349:, and
1306:with:
1280:Cancer
1109:enzyme
1060:search
1058:PubMed
919:Q9Z280
900:Q13393
796:Entrez
496:BioGPS
434:zygote
91:116234
83:109585
75:602382
4082:Types
3763:Dicer
3718:;see
3544:3.1.6
3514:PDE4B
3510:PDE4A
3448:3.1.4
3417:IMPA3
3413:IMPA2
3409:IMPA1
3287:3.1.3
3255:3.1.2
3105:3.1.1
2771:85875
2639:S2CID
2596:S2CID
2489:S2CID
2224:S2CID
1782:S2CID
1719:S2CID
1502:S2CID
1336:PEA15
1330:CDC42
1138:cell
1130:from
829:18805
789:Mouse
784:Human
755:Amigo
454:ileum
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
4174:list
4167:EC7
4161:list
4154:EC6
4148:list
4141:EC5
4135:list
4128:EC4
4122:list
4115:EC3
4109:list
4102:EC2
4096:list
4089:EC1
3681:-31:
3627:-16:
3613:and
3519:PDE5
3505:PDE3
3500:PDE2
3495:PDE1
3387:PTEN
3372:OCRL
3365:PP2A
3314:ALPP
3309:ALPL
3304:ALPI
3098:3.1)
3045:PMID
3010:PMID
2967:PMID
2932:PMID
2889:PMID
2854:PMID
2811:PMID
2776:PMID
2733:PMID
2698:PMID
2668:PMID
2631:PMID
2588:PMID
2559:PMID
2524:PMID
2481:PMID
2438:PMID
2403:PMID
2357:PMID
2308:PMID
2259:PMID
2216:PMID
2181:PMID
2140:PMID
2099:PMID
2058:PMID
2017:PMID
1973:PMID
1932:PMID
1878:PMID
1834:PMID
1812:1791
1774:PMID
1711:PMID
1657:PMID
1616:PMID
1546:PMID
1494:PMID
1376:, IC
1353:RHOA
1347:RALA
1324:BIN1
1184:and
1140:cDNA
1136:HeLa
1116:gene
1113:PLD1
810:5337
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
99:PLD1
71:OMIM
58:PLD1
35:PLD1
18:PLD1
3836:4/5
3035:doi
3000:PMC
2992:doi
2988:356
2957:doi
2953:276
2922:PMC
2914:doi
2910:355
2879:doi
2875:276
2844:PMC
2836:doi
2801:doi
2797:275
2766:PMC
2758:doi
2723:doi
2719:275
2690:doi
2660:doi
2621:doi
2580:doi
2576:430
2549:doi
2545:273
2514:doi
2510:273
2471:doi
2428:doi
2424:235
2393:doi
2389:272
2347:PMC
2339:doi
2298:PMC
2290:doi
2286:355
2251:doi
2247:302
2208:doi
2204:430
2171:doi
2167:235
2130:doi
2126:276
2089:doi
2085:275
2048:doi
2044:275
2007:doi
2003:275
1963:doi
1959:277
1922:PMC
1912:doi
1868:doi
1824:PMC
1816:doi
1764:doi
1760:119
1701:PMC
1693:doi
1647:doi
1643:168
1606:PMC
1598:doi
1594:111
1536:doi
1532:270
1486:doi
1027:n/a
301:End
200:End
103:OMA
79:MGI
4214::
3794:2C
3789:2B
3784:2A
3765::
3756::
3546::
3426::
3415:,
3411:,
3327:)/
3289::
3257::
3226:A2
3221:A1
3107::
3096:EC
3090::
3043:.
3031:11
3029:.
3025:.
3008:.
2998:.
2986:.
2982:.
2965:.
2951:.
2947:.
2930:.
2920:.
2908:.
2904:.
2887:.
2873:.
2869:.
2852:.
2842:.
2832:19
2830:.
2826:.
2809:.
2795:.
2791:.
2774:.
2764:.
2754:20
2752:.
2748:.
2731:.
2717:.
2713:.
2696:.
2686:38
2684:.
2666:.
2656:38
2654:.
2637:.
2629:.
2617:12
2615:.
2611:.
2594:.
2586:.
2574:.
2557:.
2543:.
2539:.
2522:.
2508:.
2504:.
2487:.
2479:.
2469:.
2457:.
2453:.
2436:.
2422:.
2418:.
2401:.
2387:.
2383:.
2355:.
2345:.
2335:19
2333:.
2329:.
2306:.
2296:.
2284:.
2280:.
2257:.
2245:.
2222:.
2214:.
2202:.
2179:.
2165:.
2161:.
2138:.
2124:.
2120:.
2097:.
2083:.
2079:.
2056:.
2042:.
2038:.
2015:.
2001:.
1997:.
1985:^
1971:.
1957:.
1953:.
1930:.
1920:.
1906:.
1902:.
1890:^
1876:.
1864:32
1862:.
1858:.
1846:^
1832:.
1822:.
1810:.
1806:.
1794:^
1780:.
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