29:
856:
Zatta M, Di Bella S, Bottazzi B, Rossi F, D'Agaro P, Segat L, et al. (December 2019). "Determination of pentraxin 3 levels in cerebrospinal fluid during central nervous system infections".
769:
Li XA, Yutani C, Shimokado K (March 1998). "Serum amyloid P component associates with high density lipoprotein as well as very low density lipoprotein but not with low density lipoprotein".
442:
Pentraxin 3 (PTX3) is an acute phase protein whose levels rise during severe infections in humans. In case of central nervous system infections PTX3 helps distinguishes between
523:). NPTXI and NPTXII are homologous and can exist within one species. It is suggested that both proteins mediate the uptake of synaptic macromolecules and play a role in
162:
909:
Omeis IA, Hsu YC, Perin MS (September 1996). "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization".
1014:
731:
Romero IR, Morris C, Rodriguez M, Du Clos TW, Mold C (May 1998). "Inflammatory potential of C-reactive protein complexes compared to immune complexes".
677:
Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, et al. (January 1994). "Structure of pentameric human serum amyloid P component".
357:
forming a ring approximately 95Å across and 35Å deep observed in the first members of this family to be identified. The "short" pentraxins include
98:
465:
is a vertebrate protein that is identical to tissue forms of amyloid P component. It is found in all types of amyloid deposits, in
182:
481:
ligands in a calcium-dependent manner, and it has been suggested that, in mammals, this may have important implications in
451:
466:
421:
301:
412:
in mammals. The protein resembles antibody and performs several functions associated with host defence: it promotes
1004:
549:
462:
358:
118:
1009:
170:
349:
378:
304:(PRRs). They are a superfamily of multifunctional conserved proteins, some of which are components of the
297:
166:
636:
Martinez de la Torre Y, Fabbri M, Jaillon S, Bastone A, Nebuloni M, Vecchi A, et al. (May 2010).
686:
499:
443:
317:
111:
123:
524:
891:
838:
710:
554:
447:
430:
401:
390:
377:
Three of the principal members of the pentraxin family are serum proteins: namely, CRP, SAP, and
362:
967:
926:
883:
830:
786:
748:
702:
659:
618:
189:
157:
35:
957:
918:
873:
865:
820:
778:
740:
694:
649:
610:
528:
809:"Electrophoretic polymorphism of a hamster pentraxin, female protein (amyloid P component)"
582:
149:
533:
482:
309:
305:
601:
Gewurz H, Zhang XH, Lint TF (February 1995). "Structure and function of the pentraxins".
690:
825:
808:
425:
337:
293:
962:
945:
998:
895:
614:
474:
470:
413:
103:
67:
842:
714:
417:
409:
145:
990:
434:(Atlantic horseshoe crab), where they are a normal constituent of the hemolymph.
79:
504:
486:
478:
405:
869:
313:
654:
637:
503:(the Golden hamster). The concentration of this plasma protein is altered by
922:
887:
782:
744:
663:
515:
Pentraxin proteins expressed in the nervous system are neural pentraxin I (
971:
930:
834:
790:
752:
706:
622:
107:
986:
878:
386:
289:
74:
354:
344:
329:
91:
86:
28:
39:
698:
559:
341:
333:
177:
263:
257:
251:
244:
238:
232:
226:
220:
214:
207:
201:
195:
858:
European
Journal of Clinical Microbiology & Infectious Diseases
572:
568:
564:
520:
516:
369:(a cytokine modulated molecule) and several neuronal pentraxins.
353:, pente) and axle (axis) relating to the radial symmetry of five
982:
577:
545:
Human genes encoding proteins that contain this domain include:
382:
366:
347:. The name "pentraxin" is derived from the Greek word for five (
139:
62:
531:, a sperm acrosomal protein, is a homologue of NPTXII found in
296:. Proteins of the pentraxin family are involved in acute
638:"Evolution of the pentraxin family: the new entry PTX4"
981:
This article incorporates text from the public domain
428:. CRPs have also been sequenced in an invertebrate,
771:
497:Hamster female protein is a SAP homologue found in
188:
176:
156:
138:
133:
117:
97:
85:
73:
61:
53:
48:
21:
507:and stimuli that elicit an acute phase response.
802:
800:
764:
762:
726:
724:
8:
288:, are an evolutionary conserved family of
130:
27:
961:
877:
824:
653:
424:through its calcium-dependent binding to
292:characterised by containing a pentraxin
733:Clinical Immunology and Immunopathology
593:
312:and behave as functional ancestors of
18:
365:(CRP). The "long" pentraxins include
7:
944:Reid MS, Blobel CP (December 1994).
336:binding and a distinctive flattened
950:The Journal of Biological Chemistry
316:(Abs). They are known as classical
1015:Single-pass transmembrane proteins
826:10.1046/j.1365-3083.1997.d01-109.x
813:Scandinavian Journal of Immunology
416:, bacterial capsular swelling and
14:
340:structure similar to that of the
320:(APP), known for over a century.
450:. It is significantly higher in
328:Pentraxins are characterised by
946:"Apexin, an acrosomal pentaxin"
807:Coe JE, Ross MJ (August 1997).
1:
963:10.1016/S0021-9258(18)31678-8
603:Current Opinion in Immunology
452:bacterial meningoencephalitis
408:response to tissue injury or
302:pattern recognition receptors
134:Available protein structures:
615:10.1016/0952-7915(95)80029-8
467:glomerular basement membrane
422:classical complement pathway
448:aseptic meningoencephalitis
1031:
980:
870:10.1007/s10096-019-03767-w
348:
463:Serum amyloid P component
458:Serum amyloid P component
389:-induced protein that is
385:(or TSG-14) protein is a
359:Serum Amyloid P component
129:
26:
655:10.4049/jimmunol.0901672
404:is expressed during the
477:. SAP binds to various
298:immunological responses
923:10.1006/geno.1996.0503
783:10.1006/bbrc.1998.8248
745:10.1006/clin.1997.4516
493:Hamster female protein
379:hamster female protein
300:. They are a class of
642:Journal of Immunology
500:Mesocricetus auratus
420:, and activates the
318:acute phase proteins
691:1994Natur.367..338E
525:synaptic plasticity
431:Limulus polyphemus
402:C-reactive protein
397:C-reactive protein
393:to CRPs and SAPs.
363:C reactive protein
284:), also known as
275:
274:
271:
270:
183:structure summary
1022:
1005:Protein families
976:
975:
965:
956:(51): 32615–20.
941:
935:
934:
906:
900:
899:
881:
853:
847:
846:
828:
804:
795:
794:
766:
757:
756:
728:
719:
718:
699:10.1038/367338a0
685:(6461): 338–45.
674:
668:
667:
657:
633:
627:
626:
598:
352:
266:
260:
254:
247:
241:
235:
229:
223:
217:
210:
204:
198:
131:
42:
31:
19:
1030:
1029:
1025:
1024:
1023:
1021:
1020:
1019:
1010:Protein domains
995:
994:
993:
979:
943:
942:
938:
908:
907:
903:
855:
854:
850:
806:
805:
798:
768:
767:
760:
730:
729:
722:
676:
675:
671:
635:
634:
630:
600:
599:
595:
591:
543:
534:Cavia porcellus
513:
495:
483:atherosclerosis
460:
440:
399:
375:
326:
310:innate immunity
262:
256:
250:
243:
237:
231:
225:
219:
213:
206:
200:
194:
44:
34:
33:CRP drawn from
22:Pentaxin family
17:
12:
11:
5:
1028:
1026:
1018:
1017:
1012:
1007:
997:
996:
978:
977:
936:
901:
864:(4): 665–670.
848:
796:
758:
720:
669:
648:(9): 5055–64.
628:
592:
590:
587:
586:
585:
580:
575:
562:
557:
552:
542:
539:
537:(Guinea pig).
512:
511:Nervous system
509:
494:
491:
471:elastic fibres
459:
456:
439:
436:
426:phosphocholine
398:
395:
374:
373:Family members
371:
325:
322:
294:protein domain
273:
272:
269:
268:
192:
186:
185:
180:
174:
173:
160:
154:
153:
143:
136:
135:
127:
126:
121:
115:
114:
101:
95:
94:
89:
83:
82:
77:
71:
70:
65:
59:
58:
55:
51:
50:
46:
45:
32:
24:
23:
16:Protein family
15:
13:
10:
9:
6:
4:
3:
2:
1027:
1016:
1013:
1011:
1008:
1006:
1003:
1002:
1000:
992:
988:
984:
973:
969:
964:
959:
955:
951:
947:
940:
937:
932:
928:
924:
920:
916:
912:
905:
902:
897:
893:
889:
885:
880:
879:11368/2972747
875:
871:
867:
863:
859:
852:
849:
844:
840:
836:
832:
827:
822:
818:
814:
810:
803:
801:
797:
792:
788:
784:
780:
777:(1): 249–52.
776:
772:
765:
763:
759:
754:
750:
746:
742:
739:(2): 155–62.
738:
734:
727:
725:
721:
716:
712:
708:
704:
700:
696:
692:
688:
684:
680:
673:
670:
665:
661:
656:
651:
647:
643:
639:
632:
629:
624:
620:
616:
612:
608:
604:
597:
594:
588:
584:
581:
579:
576:
574:
570:
566:
563:
561:
558:
556:
553:
551:
548:
547:
546:
540:
538:
536:
535:
530:
526:
522:
518:
510:
508:
506:
502:
501:
492:
490:
488:
484:
480:
476:
475:blood vessels
472:
468:
464:
457:
455:
453:
449:
445:
437:
435:
433:
432:
427:
423:
419:
415:
414:agglutination
411:
407:
403:
396:
394:
392:
388:
384:
380:
372:
370:
368:
364:
360:
356:
351:
346:
343:
339:
335:
331:
323:
321:
319:
315:
311:
307:
303:
299:
295:
291:
287:
283:
279:
265:
259:
253:
249:
248:E:25-220
246:
240:
234:
230:A:26-219
228:
222:
216:
211:H:26-219
209:
203:
197:
193:
191:
187:
184:
181:
179:
175:
172:
168:
164:
161:
159:
155:
151:
147:
144:
141:
137:
132:
128:
125:
122:
120:
116:
113:
109:
105:
102:
100:
96:
93:
90:
88:
84:
81:
78:
76:
72:
69:
66:
64:
60:
56:
52:
47:
41:
37:
30:
25:
20:
953:
949:
939:
917:(3): 543–5.
914:
910:
904:
861:
857:
851:
819:(2): 180–6.
816:
812:
774:
770:
736:
732:
682:
678:
672:
645:
641:
631:
609:(1): 54–64.
606:
602:
596:
544:
532:
514:
505:sex steroids
498:
496:
461:
441:
429:
418:phagocytosis
410:inflammation
400:
376:
327:
285:
281:
277:
276:
261:C:25-220
255:D:25-220
242:B:29-222
236:C:26-219
224:D:26-219
218:C:26-219
212:
205:F:26-219
199:D:32-237
487:amyloidosis
479:lipoprotein
438:Pentraxin 3
406:acute phase
338:β-jellyroll
306:humoral arm
49:Identifiers
999:Categories
589:References
519:) and II (
391:homologous
361:(SAP) and
332:dependent
314:antibodies
278:Pentraxins
146:structures
991:IPR001759
896:208812200
444:bacterial
324:Structure
286:pentaxins
92:PDOC00261
80:IPR001759
987:InterPro
911:Genomics
888:31813079
664:20357257
387:cytokine
355:monomers
290:proteins
267:A:25-220
163:RCSB PDB
75:InterPro
57:Pentaxin
972:7798266
931:8884281
843:6361670
835:9583999
791:9514915
753:9614930
715:4284282
707:8114934
687:Bibcode
623:7772283
469:and in
345:lectins
330:calcium
124:cd00152
87:PROSITE
68:PF00354
43:
970:
929:
894:
886:
841:
833:
789:
751:
713:
705:
679:Nature
662:
621:
560:GPR144
529:Apexin
521:NPTXII
381:(FP).
342:legume
334:ligand
178:PDBsum
152:
142:
112:SUPFAM
54:Symbol
892:S2CID
839:S2CID
711:S2CID
583:SVEP1
573:NPTXR
569:NPTX2
565:NPTX1
541:Human
517:NPTXI
350:πέντε
108:SCOPe
99:SCOP2
985:and
983:Pfam
968:PMID
927:PMID
884:PMID
831:PMID
787:PMID
749:PMID
703:PMID
660:PMID
619:PMID
578:PTX3
550:APCS
485:and
446:and
383:PTX3
367:PTX3
264:1gnh
258:1b09
252:1lj7
245:1crv
239:1has
233:1sac
227:1gyk
221:2a3y
215:1lgn
208:2a3x
202:2a3w
196:1lim
171:PDBj
167:PDBe
150:ECOD
140:Pfam
104:1sac
63:Pfam
40:1B09
958:doi
954:269
919:doi
874:hdl
866:doi
821:doi
779:doi
775:244
741:doi
695:doi
683:367
650:doi
646:184
611:doi
555:CRP
473:in
308:of
282:PTX
190:PDB
158:PDB
119:CDD
36:PDB
1001::
989::
966:.
952:.
948:.
925:.
915:36
913:.
890:.
882:.
872:.
862:39
860:.
837:.
829:.
817:46
815:.
811:.
799:^
785:.
773:.
761:^
747:.
737:87
735:.
723:^
709:.
701:.
693:.
681:.
658:.
644:.
640:.
617:.
605:.
571:;
567:;
527:.
489:.
454:.
169:;
165:;
148:/
110:/
106:/
38::
974:.
960::
933:.
921::
898:.
876::
868::
845:.
823::
793:.
781::
755:.
743::
717:.
697::
689::
666:.
652::
625:.
613::
607:7
280:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
