3249:
983:, respectively, and thereby triggers the release of more IgE. Because of the prevalence of Der p 1 in mite allergies, developers of HDM allergy vaccines consider it necessary to factor in Der p 1. As a result, Der p 1 is a major component of mite allergen crude extracts and is frequently used as the basis of numerous hypoallergenic derivatives created in the refinement of
29:
884:
Compared to other forms of peptidase 1, Pso o 1 shares 54% identity with Der f 1, 53% identity with Der p 1, and 53% identity with Eur m 1. A number of amino acid sequences from other peptidase 1 enzymes are shown to be conserved in Pso o 1, including enzymatic amino acids, a N-glycosylation site,
1657:
Newton, Gary K.; Perrior, Trevor R.; Jenkins, Kerry; Major, Meriel R.; Key, Rebekah E.; Stewart, Mark R.; Firth-Clark, Stuart; Lloyd, Steven M.; Zhang, Jihui; Francis-Newton, Nicola J.; Richardson, Jonathan P.; Chen, Jie; Lai, Pei; Garrod, David R.; Robinson, Clive (26 November 2014).
2146:
Kalsheker, N.A.; Deam, S.; Chambers, L.; Sreedharan, S.; Brocklehurst, K.; Lomas, D.A. (1996). "The house dust mite allergen Der p1 catalytically inactivates α1-antitrypsin by specific reactive centre loop cleavage: a mechanism that promotes airway inflammation and asthma".
2474:
Kato, T.; Takai, T.; Fujimura, T.; Matsuoka, H.; Ogawa, T.; Murayama, K.; Ishii, A.; Ikeda, S.; Okumura, K.; Ogawa, H. (September 2009). "Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes".
378:
are retained between Der p 1 and Der f 1. Due to the conserved structures, a single allergen may be used as a model in the development of drugs intended to target group 1 mite allergens, with Der p 1 usually considered the archetype. Specificity and
1473:
Lee, AJ; Machell, J; Van Den Broek, AH; Nisbet, AJ; Miller, HR; Isaac, RE; Huntley, JF (August 2002). "Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens".
2182:
Wan, Hong; Winton, Helen L.; Soeller, Christian; Tovey, Euan R.; Gruenert, Dieter C.; Thompson, Philip J.; Stewart, Geoffrey A.; Taylor, Graham W.; Garrod, David R.; Cannell, Mark B.; Robinson, Clive (1 July 1999).
2099:
NISBET, A. J.; MacKELLAR, A.; McLEAN, K.; BRENNAN, G. P.; HUNTLEY, J. F. (18 September 2006). "Eukaryotic expression of recombinant Pso o 1, an allergen from
Psoroptes ovis, and its localization in the mite".
952:. It has been suggested that the mite's gastrointestinal cells produce Der p 1. In the mite, Der p 1 is responsible for the activation of zymogens located in the mite digestive tract, including itself and the
2398:
Takai, T.; Kato, T.; Sakata, Y.; Yasueda, H.; Izuhara, K.; Okumura, K.; Ogawa, H. (2005). "Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity".
1834:
Zhang, J.; Hamilton, J. M.; Garrod, D. R.; Robinson, C. (November 2007). "Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases".
1882:"Group 1 Allergen Genes in Two Species of House Dust Mites, Dermatophagoides farinae and D-pteronyssinus (Acari: Pyroglyphidae): Direct Sequencing, Characterization and Polymorphism"
1007:. Der f 1 shows over 80% cross-reactivity with Der p 1. Like Der p 1, Der f 1 functions by cleaving CD23 to trigger an IgE response. Der f 1 also triggers an immune response through
1205:
Harris, J.; Mason, D.E.; Li, J.; Burdick, K.W.; Backes, B.J.; Chen, T.; Shipway, A.; Van Heeke, G.; Gough, L.; Ghaemmaghami, A.; Shakib, F.; Debaene, F.; Winssinger, N. (2004).
1660:"The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma"
172:
2284:
Thomas, B; Heap, P; Carswell, F (1991). "Ultrastructural localization of the allergen Der p I in the gut of the house dust mite
Dermatophagoides pteronyssinus".
191:
2601:
2237:"Proteolytic cleavage of CD25, the α subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity"
1724:"Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus"
2521:
Hales, BJ; Thomas, WR (August 1997). "T-cell sensitization to epitopes from the house dust mites
Dermatophagoides pteronyssinus and Euroglyphus maynei".
1517:
Chapman, MD; Platts-Mills, TA (August 1980). "Purification and characterization of the major allergen from
Dermatophagoides pteronyssinus-antigen P1".
881:
Pso o 1 is a 36 kDa protease composed of a 223-amino acid sequence. Pso o 1's precursor form is thought to be composed of an 81-amino acid sequence.
633:
Der f 1 is a 25 kDa protease composed of a 223-amino acid sequence. In its inactive precursor state, proDer f 1 has an 80-amino acid prodomain.
383:
between multiple group 1 allergens is thought to stem from the differences and homologies in structure, particularly regarding the positions of
1098:"Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding"
1961:
Cruz, Luz Mary; Lopez-Malpica, Fernando; Diaz, Ana Maria (June 2008). "Analysis of cross-reactivity between group 1 allergens from mites".
2968:
1722:
Herman, J; Thelen, N; Smargiasso, N; Mailleux, AC; Luxen, A; Cloes, M; De Pauw, E; Chevigné, A; Galleni, M; Dumez, ME (March 2014).
306:. By the end of the decade, it was suspected that Der p 1 was a cysteine protease when its structure showed similarities to that of
184:
2594:
956:
Der p 3, Der p 6, and Der p 9, which are then secreted as potent allergens and thereby increase the pathogenesis of the allergy.
667:
1419:"Cloning, sequence analysis, and expression of cDNA coding for the major house dust mite allergen, Der f 1, in Escherichia coli"
1026:. Eur m 1 provokes allergic responses from T cells. Der p 1 and Der f 1 show only low levels of cross-reactivity with Eur m 1.
151:
127:
3124:
1277:"A sensitive fluorescent assay for measuring the cysteine protease activity of Der p 1, a major allergen from the dust mite
1165:
Rassam, M; Laing, WA (January 2004). "Purification and characterization of phytocystatins from kiwifruit cortex and seeds".
1062:
from the house dust mite species, Pso o 1 is classified as a group 1 mite allergen alongside Der p 1, Der f 1, and Eur m 1.
779:
Eur m 1 is composed of a 223-amino acid sequence. In its inactive precursor state, Eur m 1 has an 80-amino acid prodomain.
3239:
1880:
Shafique, Rubaba Hamid; Klimov, Pavel B.; Inam, Muhammad; Chaudhary, Farhana Riaz; OConnor, Barry M. (10 December 2014).
531:
2752:
2747:
2587:
374:
Structurally, peptidase 1 enzymes are nearly identical; for example, a two-domain structure and an approximate 81%
3109:
3225:
3212:
3199:
3186:
3173:
3160:
3147:
2621:
1145:
Meighan, P.; Pirzad, R. (2004). "Mite endopeptidase 1". In
Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. (eds.).
145:
3119:
3073:
3016:
2618:
2573:
2563:
1207:"Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays"
212:
50:
132:
2324:
Banerjee, S; Weber, M; Blatt, K; Swoboda, I; Focke-Tejkl, M; Valent, P; Valenta, R; Vrtala, S (15 May 2014).
819:
3021:
2812:
717:
559:
412:
1008:
984:
659:
302:
The first allergen to be purified and characterized was Der p 1, in a 1980 study by Martin D. Chapman and
196:
286:. The group 1 mite allergens, especially Der p 1 and Der f 1, are major sources of house dust mite (HDM)
120:
3042:
2961:
524:
3114:
2373:
1931:
999:. Der f 1 is considered a major mite allergen and has been shown to promote allergic reactions in the
1559:
Chapman, Martin D.; Wuenschmann, Sabina; Pomes, Anna (September 2007). "Proteases as Th2 adjuvants".
1051:
148:
3078:
2905:
937:
910:
655:
367:, with a structure similar to that of papain. Initially, peptidase 1 is synthesized as an inactive
303:
72:
3269:
3011:
2500:
2125:
2016:
1859:
1609:
Thomas, WR; Hales, BJ; Smith, WA (July 2010). "House dust mite allergens in asthma and allergy".
1584:
1499:
375:
245:
The various forms of peptidase 1 pertaining to individual mite species comprise the group 1 mite
1365:
McNair, Carol M.; Billingsley, Peter F.; Nisbet, Alasdair J.; Knox, Dave P. (27 October 2009).
2614:
2538:
2492:
2456:
2415:
2355:
2301:
2266:
2214:
2164:
2117:
2008:
1970:
1913:
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1809:
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1689:
1626:
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1526:
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1440:
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1310:
1228:
1182:
1127:
1047:
917:
575:
498:
428:
327:
291:
235:
139:
2326:"Conversion of Der p 23, a new major house dust mite allergen, into a hypoallergenic vaccine"
3057:
3052:
3026:
2954:
2925:
2817:
2807:
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2797:
2792:
2579:
2530:
2484:
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1174:
1117:
1109:
960:
505:
487:
380:
345:
108:
2772:
920:
through inhalation. There, as group 1 mite allergens, peptidase 1 enzymes promote allergic
3104:
3088:
3001:
1246:
1059:
953:
859:
757:
650:
611:
464:
254:
84:
55:
2185:"Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions"
351:
In 2009, Der f 1 was the first observed instance of a natural allergen in the form of a
3253:
3142:
3083:
2350:
2325:
2261:
2236:
1908:
1881:
1804:
1779:
1684:
1659:
1391:
1366:
1122:
1097:
929:
364:
167:
2534:
2209:
2184:
1991:
Thomas, WR; Hales, BJ; Smith, WA (September 2005). "Structural biology of allergens".
1305:
1276:
909:. As a cysteine protease, peptidase 1 functions by cleaving other mite proteases in a
3263:
3047:
3006:
2488:
2038:"DERF1 - Peptidase 1 precursor - Dermatophagoides farinae (American house dust mite)"
1847:
1487:
1096:
Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A (2009).
1011:
921:
902:
513:
239:
2504:
2451:
2434:
2129:
1863:
1588:
1503:
1435:
1418:
1178:
987:. Even by inhibiting only Der p 1, allergic responses may be noticeably alleviated.
948:
Der p 1 is located in the mid-gut and fecal pellets of the
European house dust mite
249:. Following the naming conventions of allergens, these peptidase 1 variants include
2996:
2864:
2860:
2569:
2559:
2020:
1223:
1206:
637:
490:
975:
are targets of Der p 1, which cleaves these receptors from the surfaces of active
1898:
1739:
1622:
3220:
3155:
2991:
2935:
2930:
2900:
2884:
2879:
2874:
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1795:
869:
767:
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520:
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3248:
2411:
2915:
2729:
2698:
2693:
2688:
2683:
2113:
2004:
1572:
1417:
Cui, Y.; Zhou, P.; Peng, J.; Peng, M.; Zhou, Y.; Lin, Y.; Liu, L. (May 2008).
1336:"EURM1 - Peptidase 1 precursor - Euroglyphus maynei (Mayne's house dust mite)"
1113:
925:
835:
733:
587:
440:
342:
2341:
1382:
782:
Eur m 1 shares 88% identity with Der f 1, which has led to the proposal that
3194:
3168:
2920:
2827:
2782:
2777:
2767:
2757:
2724:
2678:
2673:
2668:
2663:
2658:
2653:
2648:
2643:
2638:
1039:
964:
933:
906:
685:
671:
641:
528:
501:
known as proDer p 1, which is then cleaved and activated by mature Der p 1.
307:
282:
2496:
2460:
2419:
2359:
2218:
2160:
2121:
2012:
1974:
1917:
1855:
1813:
1757:
1723:
1693:
1630:
1580:
1495:
1444:
1400:
1232:
1186:
1131:
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2305:
2270:
2252:
2168:
1530:
1314:
28:
2910:
2610:
2067:
2037:
1367:"Feeding-associated gene expression in sheep scab mites (Psoroptes ovis)"
1335:
840:
738:
689:
681:
678:
592:
517:
445:
331:
246:
215:
96:
1296:
1046:
is promoted by the cysteine protease activity of Pso o 1, which targets
2739:
2630:
1748:
886:
663:
645:
384:
368:
352:
287:
227:
115:
2297:
1675:
995:
Der f 1 is found in the fecal pellets of the
American house dust mite
580:
433:
35:
3207:
2977:
2787:
2719:
2714:
1034:
Pso o 1 is found in the gut and fecal pellets of the sheep scab mite
980:
976:
311:
223:
179:
91:
79:
67:
2200:
504:
Due to its cysteine protease structure, Der p 1 may be irreversibly
901:
of mites. Some of these enzymes have also been located in the mite
348:
and found it to be homologous to the other group 1 mite allergens.
3181:
2762:
1043:
898:
963:
binding levels of 80-90% and, combined with the group 2 allergen
1004:
1000:
972:
968:
928:
leakage in the respiratory tract through cleavage of the cells'
509:
494:
231:
103:
2950:
2583:
684:, which is thought to stem from the presence of the amino acid
497:
DERP1. Der p 1 is synthesized as an inactive 80-amino acid
2946:
2068:"Peptidase 1 precursor - Psoroptes ovis (Sheep scab mite)"
967:, accounting for over 50% of all HDM-related IgE binding.
666:, Der f 1 is a monomer. Der f 1 has been shown to express
534:
KCPI1 has also been shown to be able to inhibit Der p 1.
337:
In 2002, Pso o 1 was identified and characterized by Lee
2378:
US National
Library of Medicine Medical Subject Headings
2286:
International
Archives of Allergy and Applied Immunology
1936:
US National
Library of Medicine Medical Subject Headings
959:
Der p 1 is a major source of HDM allergies, triggering
363:
Peptidase 1 is a cysteine protease belonging to the C1
1728:
Biochimica et Biophysica Acta (BBA) - General Subjects
3237:
1149:(2nd ed.). London: Elsevier. pp. 1187–1189.
493:
composed of a 222-amino acid sequence encoded by the
33:
Crystal structure of Der p 1 allergen from pdb entry
1423:
Brazilian Journal of Medical and Biological Research
3133:
3097:
3066:
3035:
2984:
2893:
2826:
2738:
2707:
2629:
1022:Eur m 1 is secreted by the Mayne's house dust mite
913:that results in the activation of other allergens.
865:
855:
850:
834:
826:
814:
809:
804:
763:
753:
748:
732:
724:
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617:
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138:
126:
114:
102:
90:
78:
66:
61:
49:
44:
21:
1247:"Information on EC 3.4.22.65 - peptidase 1 (mite)"
916:Mite fecal pellets carrying peptidase 1 enter the
1778:Vrtala, S; Huber, H; Thomas, WR (1 March 2014).
905:, suggesting that these enzymes play a role in
1773:
1771:
1769:
1767:
2962:
2595:
2235:Schulz, O.; Sewell, H.F.; Shakib, F. (1998).
1275:Schulz, O.; Sewell, H.F.; Shakib, F. (1998).
1270:
1268:
8:
2141:
2139:
1986:
1984:
1932:"Dermatophagoides pteronyssinus antigen p 1"
371:, which is activated by enzymatic cleavage.
1875:
1873:
658:form than Der p 1 due to the removal of an
2969:
2955:
2947:
2602:
2588:
2580:
1091:
1089:
1087:
1085:
1083:
1081:
1079:
1077:
1075:
847:
745:
599:
452:
158:
27:
2572:at the U.S. National Library of Medicine
2562:at the U.S. National Library of Medicine
2450:
2349:
2319:
2317:
2315:
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2230:
2228:
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2094:
2092:
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2088:
1907:
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1803:
1747:
1683:
1604:
1602:
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1434:
1390:
1304:
1222:
1121:
2516:
2514:
2062:
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2058:
2032:
2030:
1829:
1827:
1825:
1823:
1717:
1715:
1713:
1711:
1709:
1707:
1705:
1703:
1360:
1358:
1356:
1200:
1198:
1196:
1160:
1158:
1156:
3244:
1956:
1954:
1952:
1780:"Recombinant house dust mite allergens"
1330:
1328:
1326:
1324:
1071:
2439:Arhiv Za Higijenu Rada I Toksikologiju
2374:"Dermatophagoides farinae antigen f 1"
1652:
1650:
1648:
1646:
1644:
1642:
1640:
1554:
1552:
1550:
1548:
1546:
1544:
1542:
1540:
1468:
1466:
1464:
1462:
1460:
1458:
1456:
1454:
801:
699:
541:
394:
326:proposed methods of Der p 1 promoting
18:
1412:
1410:
897:Peptidase 1 enzymes are found in the
7:
2435:"Arthropod allergens in urban homes"
654:, Der f 1 is easier to produce in a
1963:Puerto Rico Health Sciences Journal
1993:Current Allergy and Asthma Reports
1561:Current Allergy and Asthma Reports
14:
2535:10.1046/j.1365-2222.1997.840895.x
2523:Clinical and Experimental Allergy
2189:Journal of Clinical Investigation
692:) near the enzyme's active site.
3247:
2489:10.1111/j.1398-9995.2009.02023.x
1848:10.1111/j.1398-9995.2007.01492.x
1488:10.1046/j.1365-3024.2002.00480.x
264:of the American house dust mite
2452:10.2478/10004-1254-63-2012-2125
1436:10.1590/S0100-879X2008000500006
1179:10.1016/j.phytochem.2003.09.019
1147:Handbook of Proteolytic Enzymes
786:may be more closely related to
674:observed in different regions.
272:of the Mayne's house dust mite
16:Class of enzymes found in mites
2433:Prester, Ljerka (April 2012).
1664:Journal of Medicinal Chemistry
1279:Dermatophagoides pteronyssinus
1224:10.1016/j.chembiol.2004.08.008
950:Dermatophagoides pteronyssinus
936:release through activation of
792:Dermatophagoides pteronyssinus
636:Unlike Der p 1, Der f 1 lacks
413:Dermatophagoides pteronyssinus
258:Dermatophagoides pteronyssinus
1:
2400:Biochem. Biophys. Res. Commun
2149:Biochem. Biophys. Res. Commun
532:cysteine proteinase inhibitor
1899:10.1371/journal.pone.0114636
1740:10.1016/j.bbagen.2013.11.017
1623:10.1016/j.molmed.2010.04.008
1611:Trends in Molecular Medicine
924:, usually either by causing
677:Der f 1 can be inhibited by
1796:10.1016/j.ymeth.2013.07.034
314:. In the mid-1990s, Hewitt
3286:
2412:10.1016/j.bbrc.2005.01.051
3125:Michaelis–Menten kinetics
2114:10.1017/S0031182006001235
2005:10.1007/s11882-005-0012-1
1573:10.1007/s11882-007-0055-6
1114:10.1016/j.jmb.2008.12.049
1050:and the molecules of the
846:
744:
598:
451:
157:
26:
3017:Diffusion-limited enzyme
2574:Medical Subject Headings
2564:Medical Subject Headings
2342:10.4049/jimmunol.1400064
1251:Enzyme Database - BRENDA
997:Dermatophagoides farinae
932:or by triggering innate
885:and the Der p 1 epitope
788:Dermatophagoides farinae
560:Dermatophagoides farinae
266:Dermatophagoides farinae
2445:(Supplement-1): 47–51.
1058:belongs to a different
648:. Through secretion by
280:of the sheep scab mite
234:. This enzyme exhibits
2161:10.1006/bbrc.1996.0544
1383:10.1051/vetres/2009064
985:specific immunotherapy
688:(instead of Der p 1's
220:endopeptidase 1 (mite)
3110:Eadie–Hofstee diagram
3043:Allosteric regulation
2330:Journal of Immunology
2253:10.1084/jem.187.2.271
1519:Journal of Immunology
662:site. In solution or
341:, who determined its
3120:Lineweaver–Burk plot
1052:extracellular matrix
670:, with at least two
516:, which bind to the
238:activity with broad
2906:Cancer procoagulant
1476:Parasite Immunology
1371:Veterinary Research
1297:10.1136/mp.51.4.222
938:signal transduction
911:biochemical cascade
893:Biological function
640:for metals such as
304:Thomas Platts-Mills
3079:Enzyme superfamily
3012:Enzyme promiscuity
2615:cysteine proteases
1048:connective tissues
1024:Euroglyphus maynei
784:Euroglyphus maynei
718:Euroglyphus maynei
527:access. The major
328:allergic responses
292:temperate climates
274:Euroglyphus maynei
209:Peptidase 1 (mite)
22:Peptidase 1 (mite)
3235:
3234:
2944:
2943:
2298:10.1159/000235405
1842:(11): 1302–1309.
1676:10.1021/jm501102h
1670:(22): 9447–9462.
1217:(10): 1361–1372.
918:respiratory tract
879:
878:
875:
874:
777:
776:
773:
772:
631:
630:
627:
626:
499:protein precursor
484:
483:
480:
479:
376:sequence identity
236:cysteine protease
226:found in various
218:), also known as
206:
205:
202:
201:
121:metabolic pathway
3277:
3252:
3251:
3243:
3115:Hanes–Woolf plot
3058:Enzyme activator
3053:Enzyme inhibitor
3027:Enzyme catalysis
2971:
2964:
2957:
2948:
2926:3C-like protease
2604:
2597:
2590:
2581:
2547:
2546:
2518:
2509:
2508:
2483:(9): 1366–1374.
2471:
2465:
2464:
2454:
2430:
2424:
2423:
2395:
2389:
2388:
2386:
2384:
2370:
2364:
2363:
2353:
2321:
2310:
2309:
2281:
2275:
2274:
2264:
2232:
2223:
2222:
2212:
2179:
2173:
2172:
2143:
2134:
2133:
2096:
2083:
2082:
2080:
2078:
2064:
2053:
2052:
2050:
2048:
2034:
2025:
2024:
1988:
1979:
1978:
1958:
1947:
1946:
1944:
1942:
1928:
1922:
1921:
1911:
1901:
1877:
1868:
1867:
1831:
1818:
1817:
1807:
1775:
1762:
1761:
1751:
1719:
1698:
1697:
1687:
1654:
1635:
1634:
1606:
1593:
1592:
1556:
1535:
1534:
1514:
1508:
1507:
1470:
1449:
1448:
1438:
1414:
1405:
1404:
1394:
1362:
1351:
1350:
1348:
1346:
1332:
1319:
1318:
1308:
1272:
1263:
1262:
1260:
1258:
1243:
1237:
1236:
1226:
1202:
1191:
1190:
1162:
1151:
1150:
1142:
1136:
1135:
1125:
1093:
961:immunoglobulin E
954:serine proteases
848:
822:
802:
746:
720:
700:
600:
562:
542:
486:Der p 1 is a 25
453:
415:
395:
381:cross-reactivity
253:of the European
159:
38:
31:
19:
3285:
3284:
3280:
3279:
3278:
3276:
3275:
3274:
3260:
3259:
3258:
3246:
3238:
3236:
3231:
3143:Oxidoreductases
3129:
3105:Enzyme kinetics
3093:
3089:List of enzymes
3062:
3031:
3002:Catalytic triad
2980:
2975:
2945:
2940:
2889:
2822:
2734:
2703:
2625:
2608:
2556:
2551:
2550:
2520:
2519:
2512:
2473:
2472:
2468:
2432:
2431:
2427:
2397:
2396:
2392:
2382:
2380:
2372:
2371:
2367:
2336:(10): 4867–75.
2323:
2322:
2313:
2283:
2282:
2278:
2234:
2233:
2226:
2201:10.1172/JCI5844
2181:
2180:
2176:
2145:
2144:
2137:
2098:
2097:
2086:
2076:
2074:
2066:
2065:
2056:
2046:
2044:
2036:
2035:
2028:
1990:
1989:
1982:
1960:
1959:
1950:
1940:
1938:
1930:
1929:
1925:
1892:(12): e114636.
1879:
1878:
1871:
1833:
1832:
1821:
1777:
1776:
1765:
1721:
1720:
1701:
1656:
1655:
1638:
1608:
1607:
1596:
1558:
1557:
1538:
1516:
1515:
1511:
1472:
1471:
1452:
1416:
1415:
1408:
1364:
1363:
1354:
1344:
1342:
1334:
1333:
1322:
1274:
1273:
1266:
1256:
1254:
1245:
1244:
1240:
1204:
1203:
1194:
1164:
1163:
1154:
1144:
1143:
1139:
1095:
1094:
1073:
1068:
1040:Psoroptic mange
1032:
1020:
993:
946:
930:tight junctions
895:
818:
800:
716:
698:
660:N-glycosylation
651:Pichia pastoris
558:
540:
411:
393:
361:
300:
255:house dust mite
40:
34:
17:
12:
11:
5:
3283:
3281:
3273:
3272:
3262:
3261:
3257:
3256:
3233:
3232:
3230:
3229:
3216:
3203:
3190:
3177:
3164:
3151:
3137:
3135:
3131:
3130:
3128:
3127:
3122:
3117:
3112:
3107:
3101:
3099:
3095:
3094:
3092:
3091:
3086:
3081:
3076:
3070:
3068:
3067:Classification
3064:
3063:
3061:
3060:
3055:
3050:
3045:
3039:
3037:
3033:
3032:
3030:
3029:
3024:
3019:
3014:
3009:
3004:
2999:
2994:
2988:
2986:
2982:
2981:
2976:
2974:
2973:
2966:
2959:
2951:
2942:
2941:
2939:
2938:
2933:
2928:
2923:
2918:
2913:
2908:
2903:
2897:
2895:
2891:
2890:
2888:
2887:
2882:
2877:
2872:
2867:
2858:
2853:
2848:
2843:
2838:
2832:
2830:
2824:
2823:
2821:
2820:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2744:
2742:
2736:
2735:
2733:
2732:
2727:
2722:
2717:
2711:
2709:
2705:
2704:
2702:
2701:
2696:
2691:
2686:
2681:
2676:
2671:
2666:
2661:
2656:
2651:
2646:
2641:
2635:
2633:
2627:
2626:
2609:
2607:
2606:
2599:
2592:
2584:
2578:
2577:
2567:
2555:
2554:External links
2552:
2549:
2548:
2529:(8): 868–875.
2510:
2466:
2425:
2406:(4): 944–952.
2390:
2365:
2311:
2292:(1–4): 365–7.
2276:
2247:(2): 271–275.
2224:
2195:(1): 123–133.
2174:
2135:
2084:
2054:
2026:
1999:(5): 388–393.
1980:
1969:(2): 163–170.
1948:
1923:
1869:
1819:
1763:
1734:(3): 1117–24.
1699:
1636:
1594:
1567:(5): 363–367.
1536:
1509:
1450:
1429:(5): 380–388.
1406:
1352:
1320:
1291:(4): 222–224.
1264:
1253:. January 2015
1238:
1192:
1167:Phytochemistry
1152:
1137:
1070:
1069:
1067:
1064:
1036:Psoroptes ovis
1031:
1028:
1019:
1016:
992:
989:
945:
942:
894:
891:
877:
876:
873:
872:
867:
863:
862:
857:
853:
852:
844:
843:
838:
832:
831:
828:
824:
823:
820:Psoroptes ovis
816:
812:
811:
807:
806:
799:
796:
775:
774:
771:
770:
765:
761:
760:
755:
751:
750:
742:
741:
736:
730:
729:
726:
722:
721:
714:
710:
709:
705:
704:
697:
694:
629:
628:
625:
624:
619:
615:
614:
609:
605:
604:
596:
595:
590:
584:
583:
578:
572:
571:
568:
564:
563:
556:
552:
551:
547:
546:
539:
536:
482:
481:
478:
477:
472:
468:
467:
462:
458:
457:
449:
448:
443:
437:
436:
431:
425:
424:
421:
417:
416:
409:
405:
404:
400:
399:
392:
389:
365:protein family
360:
357:
299:
296:
283:Psoroptes ovis
204:
203:
200:
199:
194:
188:
187:
182:
176:
175:
170:
164:
163:
155:
154:
143:
136:
135:
130:
124:
123:
118:
112:
111:
106:
100:
99:
94:
88:
87:
82:
76:
75:
70:
64:
63:
59:
58:
53:
47:
46:
42:
41:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3282:
3271:
3268:
3267:
3265:
3255:
3250:
3245:
3241:
3227:
3223:
3222:
3217:
3214:
3210:
3209:
3204:
3201:
3197:
3196:
3191:
3188:
3184:
3183:
3178:
3175:
3171:
3170:
3165:
3162:
3158:
3157:
3152:
3149:
3145:
3144:
3139:
3138:
3136:
3132:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3102:
3100:
3096:
3090:
3087:
3085:
3084:Enzyme family
3082:
3080:
3077:
3075:
3072:
3071:
3069:
3065:
3059:
3056:
3054:
3051:
3049:
3048:Cooperativity
3046:
3044:
3041:
3040:
3038:
3034:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3007:Oxyanion hole
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2989:
2987:
2983:
2979:
2972:
2967:
2965:
2960:
2958:
2953:
2952:
2949:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2898:
2896:
2892:
2886:
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2862:
2859:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2833:
2831:
2829:
2825:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2745:
2743:
2741:
2737:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2712:
2710:
2708:Fruit-derived
2706:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2636:
2634:
2632:
2628:
2623:
2620:
2616:
2612:
2605:
2600:
2598:
2593:
2591:
2586:
2585:
2582:
2575:
2571:
2568:
2565:
2561:
2558:
2557:
2553:
2544:
2540:
2536:
2532:
2528:
2524:
2517:
2515:
2511:
2506:
2502:
2498:
2494:
2490:
2486:
2482:
2478:
2470:
2467:
2462:
2458:
2453:
2448:
2444:
2440:
2436:
2429:
2426:
2421:
2417:
2413:
2409:
2405:
2401:
2394:
2391:
2379:
2375:
2369:
2366:
2361:
2357:
2352:
2347:
2343:
2339:
2335:
2331:
2327:
2320:
2318:
2316:
2312:
2307:
2303:
2299:
2295:
2291:
2287:
2280:
2277:
2272:
2268:
2263:
2258:
2254:
2250:
2246:
2242:
2238:
2231:
2229:
2225:
2220:
2216:
2211:
2206:
2202:
2198:
2194:
2190:
2186:
2178:
2175:
2170:
2166:
2162:
2158:
2154:
2150:
2142:
2140:
2136:
2131:
2127:
2123:
2119:
2115:
2111:
2107:
2103:
2095:
2093:
2091:
2089:
2085:
2073:
2069:
2063:
2061:
2059:
2055:
2043:
2039:
2033:
2031:
2027:
2022:
2018:
2014:
2010:
2006:
2002:
1998:
1994:
1987:
1985:
1981:
1976:
1972:
1968:
1964:
1957:
1955:
1953:
1949:
1937:
1933:
1927:
1924:
1919:
1915:
1910:
1905:
1900:
1895:
1891:
1887:
1883:
1876:
1874:
1870:
1865:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1830:
1828:
1826:
1824:
1820:
1815:
1811:
1806:
1801:
1797:
1793:
1789:
1785:
1781:
1774:
1772:
1770:
1768:
1764:
1759:
1755:
1750:
1745:
1741:
1737:
1733:
1729:
1725:
1718:
1716:
1714:
1712:
1710:
1708:
1706:
1704:
1700:
1695:
1691:
1686:
1681:
1677:
1673:
1669:
1665:
1661:
1653:
1651:
1649:
1647:
1645:
1643:
1641:
1637:
1632:
1628:
1624:
1620:
1616:
1612:
1605:
1603:
1601:
1599:
1595:
1590:
1586:
1582:
1578:
1574:
1570:
1566:
1562:
1555:
1553:
1551:
1549:
1547:
1545:
1543:
1541:
1537:
1532:
1528:
1525:(2): 587–92.
1524:
1520:
1513:
1510:
1505:
1501:
1497:
1493:
1489:
1485:
1482:(8): 413–22.
1481:
1477:
1469:
1467:
1465:
1463:
1461:
1459:
1457:
1455:
1451:
1446:
1442:
1437:
1432:
1428:
1424:
1420:
1413:
1411:
1407:
1402:
1398:
1393:
1388:
1384:
1380:
1376:
1372:
1368:
1361:
1359:
1357:
1353:
1341:
1337:
1331:
1329:
1327:
1325:
1321:
1316:
1312:
1307:
1302:
1298:
1294:
1290:
1286:
1282:
1280:
1271:
1269:
1265:
1252:
1248:
1242:
1239:
1234:
1230:
1225:
1220:
1216:
1212:
1208:
1201:
1199:
1197:
1193:
1188:
1184:
1180:
1176:
1172:
1168:
1161:
1159:
1157:
1153:
1148:
1141:
1138:
1133:
1129:
1124:
1119:
1115:
1111:
1108:(2): 520–30.
1107:
1103:
1099:
1092:
1090:
1088:
1086:
1084:
1082:
1080:
1078:
1076:
1072:
1065:
1063:
1061:
1057:
1053:
1049:
1045:
1041:
1037:
1029:
1027:
1025:
1017:
1015:
1013:
1012:degranulation
1010:
1006:
1002:
998:
990:
988:
986:
982:
978:
974:
970:
966:
962:
957:
955:
951:
943:
941:
939:
935:
931:
927:
923:
922:sensitization
919:
914:
912:
908:
904:
900:
899:fecal pellets
892:
890:
888:
882:
871:
868:
864:
861:
858:
854:
849:
845:
842:
839:
837:
833:
829:
825:
821:
817:
813:
808:
803:
797:
795:
793:
789:
785:
780:
769:
766:
762:
759:
756:
752:
747:
743:
740:
737:
735:
731:
727:
723:
719:
715:
711:
706:
701:
695:
693:
691:
687:
683:
680:
675:
673:
669:
665:
661:
657:
653:
652:
647:
643:
639:
638:binding sites
634:
623:
620:
616:
613:
610:
606:
601:
597:
594:
591:
589:
585:
582:
579:
577:
573:
569:
565:
561:
557:
553:
548:
543:
537:
535:
533:
530:
526:
522:
519:
515:
514:iodoacetamide
511:
507:
502:
500:
496:
492:
489:
476:
473:
469:
466:
463:
459:
454:
450:
447:
444:
442:
438:
435:
432:
430:
426:
422:
418:
414:
410:
406:
401:
396:
390:
388:
386:
382:
377:
372:
370:
366:
358:
356:
354:
349:
347:
344:
340:
335:
333:
329:
325:
321:
317:
313:
309:
305:
297:
295:
293:
289:
285:
284:
279:
275:
271:
267:
263:
259:
256:
252:
248:
243:
242:specificity.
241:
240:endopeptidase
237:
233:
229:
225:
221:
217:
214:
210:
198:
195:
193:
189:
186:
183:
181:
177:
174:
171:
169:
165:
160:
156:
153:
150:
147:
144:
141:
137:
134:
131:
129:
125:
122:
119:
117:
113:
110:
107:
105:
101:
98:
97:NiceZyme view
95:
93:
89:
86:
83:
81:
77:
74:
71:
69:
65:
60:
57:
54:
52:
48:
43:
37:
30:
25:
20:
3221:Translocases
3218:
3205:
3192:
3179:
3166:
3156:Transferases
3153:
3140:
2997:Binding site
2526:
2522:
2480:
2476:
2469:
2442:
2438:
2428:
2403:
2399:
2393:
2381:. Retrieved
2377:
2368:
2333:
2329:
2289:
2285:
2279:
2244:
2240:
2192:
2188:
2177:
2155:(1): 59–61.
2152:
2148:
2105:
2102:Parasitology
2101:
2075:. Retrieved
2071:
2045:. Retrieved
2041:
1996:
1992:
1966:
1962:
1939:. Retrieved
1935:
1926:
1889:
1885:
1839:
1835:
1790:(1): 67–74.
1787:
1783:
1731:
1727:
1667:
1663:
1617:(7): 321–8.
1614:
1610:
1564:
1560:
1522:
1518:
1512:
1479:
1475:
1426:
1422:
1374:
1370:
1343:. Retrieved
1339:
1288:
1284:
1278:
1255:. Retrieved
1250:
1241:
1214:
1210:
1173:(1): 19–30.
1170:
1166:
1146:
1140:
1105:
1102:J. Mol. Biol
1101:
1055:
1035:
1033:
1023:
1021:
996:
994:
958:
949:
947:
915:
896:
883:
880:
791:
787:
783:
781:
778:
676:
668:polymorphism
649:
635:
632:
503:
491:glycoprotein
485:
373:
362:
350:
338:
336:
334:activities.
330:through its
323:
319:
315:
301:
281:
277:
273:
269:
265:
261:
257:
250:
244:
219:
208:
207:
85:BRENDA entry
2992:Active site
2936:Gingipain K
2931:Gingipain R
2901:Clostripain
2241:J. Exp. Med
2108:(1): 83–9.
1749:2268/163997
1285:Mol. Pathol
1054:. Although
860:Swiss-model
810:Identifiers
805:Peptidase 1
758:Swiss-model
708:Identifiers
703:Peptidase 1
656:recombinant
612:Swiss-model
550:Identifiers
545:Peptidase 1
521:active site
465:Swiss-model
403:Identifiers
398:Peptidase 1
322:, and King
73:IntEnz view
45:Identifiers
3195:Isomerases
3169:Hydrolases
3036:Regulation
2916:Autophagin
2730:Actinidain
2699:Caspase 14
2694:Caspase 13
2689:Caspase 12
2684:Caspase 10
1211:Chem. Biol
1066:References
1009:eosinophil
940:pathways.
926:epithelial
856:Structures
851:Search for
754:Structures
749:Search for
672:haplotypes
608:Structures
603:Search for
523:and block
461:Structures
456:Search for
343:amino acid
142:structures
109:KEGG entry
3270:EC 3.4.22
3074:EC number
2921:Cruzipain
2828:Cathepsin
2725:Bromelain
2679:Caspase 9
2674:Caspase 8
2669:Caspase 7
2664:Caspase 6
2659:Caspase 5
2654:Caspase 4
2649:Caspase 3
2644:Caspase 2
2639:Caspase 1
2611:Proteases
1377:(2): 16.
1056:Psoroptes
934:chemokine
907:digestion
642:magnesium
529:kiwifruit
525:substrate
506:inhibited
359:Structure
318:, Shakib
308:actinidin
288:allergies
247:allergens
216:3.4.22.65
62:Databases
56:3.4.22.65
3264:Category
3098:Kinetics
3022:Cofactor
2985:Activity
2911:Separase
2505:20947793
2497:19416145
2461:22548852
2420:15707969
2360:24733847
2219:10393706
2130:46361359
2122:16978441
2077:12 April
2047:12 April
2013:16091212
1975:18616045
1918:25494056
1886:PLOS ONE
1864:11144482
1856:17919146
1814:23911838
1758:24291687
1694:25365789
1631:20605742
1589:35472783
1581:17697645
1504:37215478
1496:12406195
1445:18545812
1401:19852923
1345:27 March
1257:11 April
1233:15489163
1187:14697268
1132:19136006
870:InterPro
815:Organism
768:InterPro
713:Organism
682:cystatin
679:chestnut
622:InterPro
555:Organism
518:cysteine
475:InterPro
408:Organism
385:epitopes
346:sequence
332:protease
222:, is an
197:proteins
185:articles
173:articles
146:RCSB PDB
3254:Biology
3208:Ligases
2978:Enzymes
2740:Calpain
2631:Caspase
2570:Der+f+1
2560:Der+p+1
2543:9291282
2477:Allergy
2383:3 April
2351:4582415
2306:1937901
2271:9432986
2262:2212095
2169:8660343
2072:UniProt
2042:UniProt
2021:2552454
1941:3 April
1909:4262422
1836:Allergy
1805:4582397
1784:Methods
1685:4257840
1531:6771329
1392:2789330
1340:UniProt
1315:9893750
1123:2677027
1030:Pso o 1
1018:Eur m 1
991:Der f 1
981:T cells
977:B cells
965:Der p 2
944:Der p 1
866:Domains
836:UniProt
798:Pso o 1
764:Domains
734:UniProt
696:Eur m 1
664:crystal
646:calcium
618:Domains
588:UniProt
538:Der f 1
471:Domains
441:UniProt
391:Der p 1
369:zymogen
353:monomer
298:History
278:Pso o 1
270:Eur m 1
262:Der f 1
251:Der p 1
228:species
133:profile
116:MetaCyc
39:
3240:Portal
3182:Lyases
2818:CAPNS2
2813:CAPNS1
2808:CAPN14
2803:CAPN13
2798:CAPN12
2793:CAPN11
2788:CAPN10
2720:Ficain
2715:Papain
2622:3.4.22
2576:(MeSH)
2566:(MeSH)
2541:
2503:
2495:
2459:
2418:
2358:
2348:
2304:
2269:
2259:
2217:
2210:408401
2207:
2167:
2128:
2120:
2019:
2011:
1973:
1916:
1906:
1862:
1854:
1812:
1802:
1756:
1692:
1682:
1629:
1587:
1579:
1529:
1502:
1494:
1443:
1399:
1389:
1313:
1306:395641
1303:
1231:
1185:
1130:
1120:
889:-Gln.
841:Q1EIQ3
827:Symbol
739:P25780
725:Symbol
593:P16311
567:Symbol
446:P08176
420:Symbol
339:et al.
324:et al.
320:et al.
316:et al.
312:papain
276:; and
224:enzyme
180:PubMed
162:Search
152:PDBsum
92:ExPASy
80:BRENDA
68:IntEnz
51:EC no.
3134:Types
2894:Other
2783:CAPN9
2778:CAPN8
2773:CAPN7
2768:CAPN6
2763:CAPN5
2758:CAPN3
2753:CAPN2
2748:CAPN1
2501:S2CID
2126:S2CID
2017:S2CID
1860:S2CID
1585:S2CID
1500:S2CID
1060:order
1044:sheep
1001:lungs
830:PSOO1
790:than
728:EURM1
570:DERF1
423:DERP1
232:mites
128:PRIAM
3226:list
3219:EC7
3213:list
3206:EC6
3200:list
3193:EC5
3187:list
3180:EC4
3174:list
3167:EC3
3161:list
3154:EC2
3148:list
3141:EC1
2539:PMID
2493:PMID
2457:PMID
2416:PMID
2385:2015
2356:PMID
2302:PMID
2267:PMID
2215:PMID
2165:PMID
2118:PMID
2079:2015
2049:2015
2009:PMID
1971:PMID
1943:2015
1914:PMID
1852:PMID
1810:PMID
1754:PMID
1732:1840
1690:PMID
1627:PMID
1577:PMID
1527:PMID
1492:PMID
1441:PMID
1397:PMID
1347:2015
1311:PMID
1259:2015
1229:PMID
1183:PMID
1128:PMID
1005:skin
1003:and
979:and
973:CD25
971:and
969:CD23
644:and
581:3RVV
510:E-64
495:gene
434:1XKG
310:and
192:NCBI
149:PDBe
104:KEGG
36:3F5V
2531:doi
2485:doi
2447:doi
2408:doi
2404:328
2346:PMC
2338:doi
2334:192
2294:doi
2257:PMC
2249:doi
2245:187
2205:PMC
2197:doi
2193:104
2157:doi
2153:221
2110:doi
2106:134
2001:doi
1904:PMC
1894:doi
1844:doi
1800:PMC
1792:doi
1744:hdl
1736:doi
1680:PMC
1672:doi
1619:doi
1569:doi
1523:125
1484:doi
1431:doi
1387:PMC
1379:doi
1301:PMC
1293:doi
1219:doi
1175:doi
1118:PMC
1110:doi
1106:386
1042:in
903:gut
887:Leu
690:Arg
686:Gln
576:PDB
512:or
508:by
488:kDa
429:PDB
290:in
230:of
168:PMC
140:PDB
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2865:L2
2861:L1
2619:EC
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