109:, dissolution of glass, and formation of the HA layer that promotes cellular response of tissues. The high specific surface area of bioactive glasses is likely to induce quicker solubility of the material, availability of ions in the surrounding area, and enhanced protein adsorption ability. These factors altogether contribute toward the bioactivity of bioglass coatings. In addition, tissue mineralization (bone, teeth) is promoted while tissue forming cells are in direct contact with bioglass materials.
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but can be modified by the other constituents. Among the various properties of chemical compounds, pharmacological/biological activity plays a crucial role since it suggests uses of the compounds in the medical applications. However, chemical compounds may show some adverse and toxic effects which
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criteria. To be an effective drug, a compound not only must be active against a target, but also possess the appropriate ADME (Absorption, Distribution, Metabolism, and
Excretion) properties necessary to make it suitable for use as a drug. Because of the costs of the measurement, biological
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A.Jagan Mohan Reddy; Manas Ranjan Barik; Gajendra L. Muli & Parthasarathy.T (2012). "Computational
Approach for Designing and Development of Potent Inhibitor for Hepatitis – B Virus X- Associated Protein through Molecular Docking Studies".
215:
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Chakraborty, R.; Raza; M.S. & Datta (2019). "Synthesis and characterization of nickel free titanium–hydroxyapatite composite coating over
Nitinol surface through in-situ laser cladding and alloying".
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coatings represent high surface area and reactivity leading to an effective interaction of the coating material and surrounding bone tissues. In the biological environment, the formation of a layer of
81:. Further, it is common to have effects ranging from beneficial to adverse for one substance when going from low to high doses. Activity depends critically on fulfillment of the
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Zafar, M.S.; Farooq; Awais & Najeeb (2019). "Bioactive surface coatings for enhancing osseointegration of dental implants".
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This article is about biological activity of pharmaceuticals. For biological activity as interactions of living organisms, see
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Bioactivity is a key property that promotes osseointegration for bonding and better stability of dental implants.
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Etymology: Gk, bios, life; L, activus, with energy, Mosby's
Medical Dictionary, 8th edition. © 2009, Elsevier.
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Whereas a material is considered bioactive if it has interaction with or effect on any
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101:(CHA) initiates bonding to the bone tissues. The bioglass surface coating undergoes
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Miller-Keane
Encyclopedia & Dictionary of Medicine, Nursing, and Allied Health
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Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses
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activities are often predicted with computational methods, so-called
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147:with ion content similar to
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124:as well as a substance's
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606:Investigational New Drug
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47:pharmacological activity
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407:Pharmaceutical sciences
171:Lipinski's rule of five
691:-related article is a
18:Pharmacological effect
563:Pharmacist prescriber
548:Consultant pharmacist
631:Pharmacies of Norway
568:Pharmacy informatics
462:Pharmacoepidemiology
371:Prehistoric medicine
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79:dose-response curves
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43:biological activity
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