1710:
1690:
29:
598:
Meyer E, Stubbe J, Kappock TJ, Osuji C (1999). "Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by
539:
purine biosynthesis. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. Some members of this family contain two copies of this domain.
790:
699:
449:
1138:
499:
194:
421:
899:
529:
259:
213:
775:
692:
865:
1257:
1131:
1008:
1751:
685:
417:
1770:
1340:
1238:
1188:
283:
1262:
1124:
1409:
1223:
904:
1253:
1178:
1012:
765:
271:
206:
1228:
1045:
978:
925:
264:
654:
1285:
983:
795:
770:
157:
133:
1565:
1090:
780:
1680:
1307:
1003:
475:
The crystal structure of PurE indicates a unique quaternary structure that confirms the octameric nature of the enzyme.
1780:
641:
1744:
1218:
1173:
1550:
1666:
1653:
1640:
1627:
1614:
1601:
1588:
1350:
1322:
1272:
1208:
1161:
819:
1560:
151:
1514:
1457:
1374:
1152:
1085:
645:
399:
324:
44:
138:
1462:
1213:
1198:
1193:
1105:
849:
808:
677:
1243:
1183:
824:
506:
434:
276:
218:
1737:
1483:
1402:
1059:
954:
518:
126:
1555:
1203:
1100:
341:
61:
233:
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
1519:
1077:
1050:
920:
413:
154:
56:
559:"Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway"
78:
1452:
1312:
891:
750:
714:
1775:
930:
860:
732:
620:
580:
145:
1721:
1709:
1498:
1493:
1467:
1395:
1335:
935:
612:
570:
491:
336:
495:
the reaction is catalyzed in two steps carried out by two separate enzymes, PurK and PurE.
329:
114:
1545:
1529:
1442:
658:
365:
345:
90:
402:
49:
1694:
1583:
1524:
1165:
1095:
1025:
988:
461:
189:
575:
558:
169:
1764:
1488:
1447:
1359:
940:
875:
834:
754:
164:
1717:
1437:
651:
409:
673:
300:
1661:
1596:
1432:
1116:
510:
375:
173:
1689:
1364:
1300:
1295:
1290:
973:
719:
710:
406:
307:
1635:
1609:
1369:
522:
624:
584:
472:, but consists of two non-interacting proteins in bacteria, PurK and PurE.
1276:
669:
487:
312:
102:
1326:
1248:
505:, catalyzes the conversion of 5-aminoimidazole ribonucleotide ("AIR"),
121:
616:
1648:
1418:
722:
388:
295:
201:
97:
85:
73:
1622:
1148:
469:
465:
1063:
1054:
665:
288:
109:
28:
1391:
1120:
681:
1387:
438:
1725:
791:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
33:
Phosphoribosylaminoimidazole carboxylase octamer, Human
664:
This article incorporates text from the public domain
1678:
437:
557:
Ealick SE, Stubbe J, Kappock TJ, Mathews II (1999).
517:
5-carboxyaminoimidazole ribonucleotide ("N5-CAIR"),
1574:
1538:
1507:
1476:
1425:
1349:
1321:
1271:
1160:
1076:
1038:
962:
953:
913:
890:
845:
804:
747:
740:
731:
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163:
144:
132:
120:
108:
96:
84:
72:
67:
55:
43:
38:
21:
451:5'-phosphoribosyl-4-carboxy-5-aminoimidazole + 2 H
443:
503:5-carboxyaminoimidazole ribonucleotide synthetase
900:Hypoxanthine-guanine phosphoribosyltransferase
535:, converts N5-CAIR to CAIR, the sixth step of
460:Phosphoribosylaminoimidazole carboxylase is a
1745:
1403:
1132:
693:
533:5-carboxyaminoimidazole ribonucleotide mutase
8:
422:5'-phosphoribosyl-4-carboxy-5-aminoimidazole
776:Phosphoribosylglycinamide formyltransferase
1752:
1738:
1410:
1396:
1388:
1139:
1125:
1117:
966:
959:
744:
737:
700:
686:
678:
353:
180:
644:at the U.S. National Library of Medicine
574:
436:
1234:Phosphoribosylaminoimidazole carboxylase
786:Phosphoribosylaminoimidazole carboxylase
642:phosphoribosylaminoimidazole+carboxylase
392:Phosphoribosylaminoimidazole carboxylase
22:Phosphoribosylaminoimidazole carboxylase
1685:
549:
424:("CAIR") as described in the reaction:
229:
18:
7:
1706:
1704:
1341:3-hydroxy-3-methylglutaryl-CoA lyase
1258:Orotidine 5'-phosphate decarboxylase
1009:Orotidine 5'-phosphate decarboxylase
428:5-aminoimidazole ribonucleotide + CO
1239:Pyrophosphomevalonate decarboxylase
1189:Aromatic L-amino acid decarboxylase
444:{\displaystyle \rightleftharpoons }
16:Enzyme involved in purine synthesis
1724:. You can help Knowledge (XXG) by
1263:Uroporphyrinogen III decarboxylase
418:5'-phosphoribosyl-5-aminoimidazole
14:
1224:Phosphoenolpyruvate carboxykinase
905:Adenine phosphoribosyltransferase
416:. It catalyzes the conversion of
1708:
1688:
1254:Uridine monophosphate synthetase
1179:Adenosylmethionine decarboxylase
1013:Uridine monophosphate synthetase
766:Ribose-phosphate diphosphokinase
27:
1229:Phosphoenolpyruvate carboxylase
1046:Dihydropyrimidine dehydrogenase
979:Carbamoyl phosphate synthase II
926:Purine nucleoside phosphorylase
1286:Fructose-bisphosphate aldolase
984:Aspartate carbamoyltransferase
771:Amidophosphoribosyltransferase
1:
1091:Nucleoside-diphosphate kinase
781:AIR synthetase (FGAM cyclase)
576:10.1016/S0969-2126(00)80029-5
1308:2-hydroxyphytanoyl-CoA lyase
1004:Dihydroorotate dehydrogenase
1771:Genes on human chromosome 4
1797:
1703:
1219:Oxaloacetate decarboxylase
1174:Acetoacetate decarboxylase
663:
603:PurE, an N5-CAIR mutase".
1566:Michaelis–Menten kinetics
1209:Malonyl-CoA decarboxylase
1021:
999:
969:
820:Adenylosuccinate synthase
352:
179:
26:
1458:Diffusion-limited enzyme
1375:Spore photoproduct lyase
1086:Ribonucleotide reductase
646:Medical Subject Headings
1214:Ornithine decarboxylase
1199:Histidine decarboxylase
1194:Glutamate decarboxylase
1106:Dihydrofolate reductase
1244:Pyruvate decarboxylase
1184:Arginine decarboxylase
825:Adenylosuccinate lyase
445:
1551:Eadie–Hofstee diagram
1484:Allosteric regulation
1060:Beta-ureidopropionase
955:Pyrimidine metabolism
715:amino acid metabolism
446:
412:and in particular in
1561:Lineweaver–Burk plot
1204:Lysine decarboxylase
1101:Thymidylate synthase
1078:Deoxyribonucleotides
435:
1051:Dihydropyrimidinase
921:Adenosine deaminase
456:In plants and fungi
414:purine biosynthesis
1781:Biochemistry stubs
1520:Enzyme superfamily
1453:Enzyme promiscuity
1313:Threonine aldolase
892:Nucleotide salvage
657:2017-12-22 at the
441:
1733:
1732:
1676:
1675:
1385:
1384:
1114:
1113:
1072:
1071:
1034:
1033:
949:
948:
931:Guanine deaminase
886:
885:
861:IMP dehydrogenase
733:Purine metabolism
617:10.1021/bi9827159
611:(10): 3012–3018.
569:(11): 1395–1406.
405:) is involved in
385:
384:
381:
380:
228:
227:
224:
223:
127:metabolic pathway
1788:
1754:
1747:
1740:
1712:
1705:
1693:
1692:
1684:
1556:Hanes–Woolf plot
1499:Enzyme activator
1494:Enzyme inhibitor
1468:Enzyme catalysis
1412:
1405:
1398:
1389:
1336:Isocitrate lyase
1141:
1134:
1127:
1118:
967:
960:
936:Xanthine oxidase
854:
813:
759:
745:
738:
702:
695:
688:
679:
629:
628:
601:Escherichia coli
595:
589:
588:
578:
554:
492:Escherichia coli
481:Escherichia coli
450:
448:
447:
442:
354:
230:
181:
31:
19:
1796:
1795:
1791:
1790:
1789:
1787:
1786:
1785:
1761:
1760:
1759:
1758:
1701:
1699:
1687:
1679:
1677:
1672:
1584:Oxidoreductases
1570:
1546:Enzyme kinetics
1534:
1530:List of enzymes
1503:
1472:
1443:Catalytic triad
1421:
1416:
1386:
1381:
1345:
1317:
1267:
1156:
1145:
1115:
1110:
1068:
1030:
1017:
995:
945:
909:
882:
846:
841:
805:
800:
748:
727:
706:
676:
659:Wayback Machine
638:
633:
632:
597:
596:
592:
556:
555:
551:
546:
484:
458:
433:
432:
431:
396:AIR carboxylase
34:
17:
12:
11:
5:
1794:
1792:
1784:
1783:
1778:
1773:
1763:
1762:
1757:
1756:
1749:
1742:
1734:
1731:
1730:
1713:
1698:
1697:
1674:
1673:
1671:
1670:
1657:
1644:
1631:
1618:
1605:
1592:
1578:
1576:
1572:
1571:
1569:
1568:
1563:
1558:
1553:
1548:
1542:
1540:
1536:
1535:
1533:
1532:
1527:
1522:
1517:
1511:
1509:
1508:Classification
1505:
1504:
1502:
1501:
1496:
1491:
1486:
1480:
1478:
1474:
1473:
1471:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1429:
1427:
1423:
1422:
1417:
1415:
1414:
1407:
1400:
1392:
1383:
1382:
1380:
1379:
1378:
1377:
1372:
1362:
1356:
1354:
1347:
1346:
1344:
1343:
1338:
1332:
1330:
1319:
1318:
1316:
1315:
1310:
1305:
1304:
1303:
1298:
1293:
1282:
1280:
1269:
1268:
1266:
1265:
1260:
1251:
1246:
1241:
1236:
1231:
1226:
1221:
1216:
1211:
1206:
1201:
1196:
1191:
1186:
1181:
1176:
1170:
1168:
1166:Carboxy-lyases
1158:
1157:
1147:Carbon–carbon
1146:
1144:
1143:
1136:
1129:
1121:
1112:
1111:
1109:
1108:
1103:
1098:
1096:DCMP deaminase
1093:
1088:
1082:
1080:
1074:
1073:
1070:
1069:
1067:
1066:
1057:
1048:
1042:
1040:
1036:
1035:
1032:
1031:
1029:
1028:
1026:CTP synthetase
1022:
1019:
1018:
1016:
1015:
1006:
1000:
997:
996:
994:
993:
992:
991:
989:Dihydroorotase
986:
981:
970:
964:
957:
951:
950:
947:
946:
944:
943:
938:
933:
928:
923:
917:
915:
911:
910:
908:
907:
902:
896:
894:
888:
887:
884:
883:
881:
880:
879:
878:
868:
863:
857:
855:
843:
842:
840:
839:
838:
837:
827:
822:
816:
814:
802:
801:
799:
798:
793:
788:
783:
778:
773:
768:
762:
760:
742:
735:
729:
728:
726:
725:
717:
707:
705:
704:
697:
690:
682:
662:
661:
649:
637:
636:External links
634:
631:
630:
590:
548:
547:
545:
542:
483:
477:
462:fusion protein
457:
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440:
429:
383:
382:
379:
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373:
369:
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210:
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198:
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136:
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124:
118:
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106:
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94:
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32:
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15:
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10:
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4:
3:
2:
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1782:
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1755:
1750:
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1743:
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1729:
1727:
1723:
1720:article is a
1719:
1714:
1711:
1707:
1702:
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1686:
1682:
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1664:
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1658:
1655:
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1638:
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1632:
1629:
1625:
1624:
1619:
1616:
1612:
1611:
1606:
1603:
1599:
1598:
1593:
1590:
1586:
1585:
1580:
1579:
1577:
1573:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1543:
1541:
1537:
1531:
1528:
1526:
1525:Enzyme family
1523:
1521:
1518:
1516:
1513:
1512:
1510:
1506:
1500:
1497:
1495:
1492:
1490:
1489:Cooperativity
1487:
1485:
1482:
1481:
1479:
1475:
1469:
1466:
1464:
1461:
1459:
1456:
1454:
1451:
1449:
1448:Oxyanion hole
1446:
1444:
1441:
1439:
1436:
1434:
1431:
1430:
1428:
1424:
1420:
1413:
1408:
1406:
1401:
1399:
1394:
1393:
1390:
1376:
1373:
1371:
1368:
1367:
1366:
1363:
1361:
1360:Tryptophanase
1358:
1357:
1355:
1352:
1348:
1342:
1339:
1337:
1334:
1333:
1331:
1328:
1324:
1320:
1314:
1311:
1309:
1306:
1302:
1299:
1297:
1294:
1292:
1289:
1288:
1287:
1284:
1283:
1281:
1278:
1274:
1270:
1264:
1261:
1259:
1255:
1252:
1250:
1247:
1245:
1242:
1240:
1237:
1235:
1232:
1230:
1227:
1225:
1222:
1220:
1217:
1215:
1212:
1210:
1207:
1205:
1202:
1200:
1197:
1195:
1192:
1190:
1187:
1185:
1182:
1180:
1177:
1175:
1172:
1171:
1169:
1167:
1163:
1159:
1154:
1150:
1142:
1137:
1135:
1130:
1128:
1123:
1122:
1119:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1083:
1081:
1079:
1075:
1065:
1061:
1058:
1056:
1052:
1049:
1047:
1044:
1043:
1041:
1037:
1027:
1024:
1023:
1020:
1014:
1010:
1007:
1005:
1002:
1001:
998:
990:
987:
985:
982:
980:
977:
976:
975:
972:
971:
968:
965:
961:
958:
956:
952:
942:
941:Urate oxidase
939:
937:
934:
932:
929:
927:
924:
922:
919:
918:
916:
912:
906:
903:
901:
898:
897:
895:
893:
889:
877:
876:GMP reductase
874:
873:
872:
869:
867:
864:
862:
859:
858:
856:
853:
851:
844:
836:
835:AMP deaminase
833:
832:
831:
828:
826:
823:
821:
818:
817:
815:
812:
810:
803:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
763:
761:
758:
756:
752:
746:
743:
739:
736:
734:
730:
724:
721:
718:
716:
712:
709:
708:
703:
698:
696:
691:
689:
684:
683:
680:
675:
671:
667:
660:
656:
653:
650:
647:
643:
640:
639:
635:
626:
622:
618:
614:
610:
606:
602:
594:
591:
586:
582:
577:
572:
568:
564:
560:
553:
550:
543:
541:
538:
534:
532:
526:
524:
520:
516:
512:
508:
504:
502:
496:
494:
493:
489:
482:
478:
476:
473:
471:
467:
463:
455:
427:
426:
425:
423:
420:("AIR") into
419:
415:
411:
408:
404:
401:
397:
393:
390:
377:
374:
370:
367:
364:
360:
355:
351:
348:
347:
343:
340:
338:
334:
331:
328:
326:
322:
317:
314:
311:
309:
305:
302:
299:
297:
293:
290:
287:
285:
281:
278:
275:
273:
269:
266:
263:
261:
257:
253:
249:
245:
241:
236:
231:
220:
217:
215:
211:
208:
205:
203:
199:
196:
193:
191:
187:
182:
178:
175:
171:
168:
166:
165:Gene Ontology
162:
159:
156:
153:
150:
147:
143:
140:
137:
135:
131:
128:
125:
123:
119:
116:
113:
111:
107:
104:
103:NiceZyme view
101:
99:
95:
92:
89:
87:
83:
80:
77:
75:
71:
66:
63:
60:
58:
54:
51:
48:
46:
42:
37:
30:
25:
20:
1726:expanding it
1718:biochemistry
1715:
1700:
1662:Translocases
1659:
1646:
1633:
1620:
1607:
1597:Transferases
1594:
1581:
1438:Binding site
1233:
870:
866:GMP synthase
847:
829:
806:
796:IMP synthase
785:
749:
608:
605:Biochemistry
604:
600:
593:
566:
562:
552:
536:
530:
527:
514:
500:
497:
490:
485:
480:
474:
459:
410:biosynthesis
395:
391:
386:
344:
251:Alt. symbols
91:BRENDA entry
1433:Active site
652:PAICS photo
511:bicarbonate
366:Swiss-model
238:Identifiers
79:IntEnz view
39:Identifiers
1765:Categories
1636:Isomerases
1610:Hydrolases
1477:Regulation
1365:Photolyase
1301:Aldolase C
1296:Aldolase B
1291:Aldolase A
1039:Catabolism
914:Catabolism
720:nucleotide
711:Metabolism
544:References
407:nucleotide
362:Structures
357:Search for
319:Other data
148:structures
115:KEGG entry
62:9032-04-6
1515:EC number
1370:CPD lyase
963:Anabolism
741:Anabolism
674:IPR000031
563:Structure
523:phosphate
488:bacterium
439:⇌
325:EC number
301:NM_006452
260:NCBI gene
68:Databases
1776:EC 4.1.1
1539:Kinetics
1463:Cofactor
1426:Activity
1327:Oxo-acid
1277:Aldehyde
670:InterPro
655:Archived
625:10074353
585:10574791
403:4.1.1.21
376:InterPro
346:pter-q21
330:4.1.1.21
219:proteins
207:articles
195:articles
152:RCSB PDB
50:4.1.1.21
1695:Biology
1649:Ligases
1419:Enzymes
1353:: Other
1329:-lyases
1279:-lyases
1249:RuBisCO
871:reverse
830:reverse
723:enzymes
537:de novo
486:In the
372:Domains
308:UniProt
174:QuickGO
139:profile
122:MetaCyc
57:CAS no.
1681:Portal
1623:Lyases
1351:4.1.99
1149:lyases
648:(MeSH)
623:
583:
528:PurE,
521:, and
509:, and
498:PurK,
466:plants
389:enzyme
342:Chr. 4
313:P22234
296:RefSeq
289:172439
243:Symbol
202:PubMed
184:Search
170:AmiGO
158:PDBsum
98:ExPASy
86:BRENDA
74:IntEnz
45:EC no.
1716:This
1575:Types
1323:4.1.3
1273:4.1.2
1162:4.1.1
470:fungi
394:, or
337:Locus
265:10606
246:PAICS
134:PRIAM
1722:stub
1667:list
1660:EC7
1654:list
1647:EC6
1641:list
1634:EC5
1628:list
1621:EC4
1615:list
1608:EC3
1602:list
1595:EC2
1589:list
1582:EC1
1155:4.1)
1064:UPB1
1055:DPYS
848:IMP→
807:IMP→
668:and
666:Pfam
621:PMID
581:PMID
468:and
387:The
284:OMIM
277:8587
272:HGNC
254:PAIS
214:NCBI
155:PDBe
110:KEGG
974:CAD
850:GMP
809:AMP
755:IMP
751:R5P
613:doi
571:doi
519:ADP
513:to
507:ATP
479:In
464:in
190:PMC
146:PDB
1767::
1325::
1275::
1164::
1153:EC
713::
672::
619:.
609:38
607:.
579:.
565:.
561:.
525:.
400:EC
172:/
1753:e
1746:t
1739:v
1728:.
1683::
1669:)
1665:(
1656:)
1652:(
1643:)
1639:(
1630:)
1626:(
1617:)
1613:(
1604:)
1600:(
1591:)
1587:(
1411:e
1404:t
1397:v
1256:/
1151:(
1140:e
1133:t
1126:v
1062:/
1053:/
1011:/
852::
811::
757::
753:→
701:e
694:t
687:v
627:.
615::
587:.
573::
567:7
531:N
515:N
501:N
430:2
398:(
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