2210:
240:
29:
1017:"Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants"
904:"Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide"
1781:
570:
In bacteria and plants this protein domain only catalyses the synthesis of SAICAR. However, in mammals it also catalyses phosphoribosylaminoimidazole carboxylase (AIRC) activity.
454:
363:
194:
1981:
1173:
213:
1857:
1774:
1238:
526:. Furthermore, they are of specific interest to scientific researchers as the study of the purine biosynthesis pathway could lead to the development of
2267:
1947:
1430:
772:"Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SAICAR synthase from Streptococcus suis serotype 2"
1867:
2090:
1378:
1767:
299:
1344:
586:
flanked by three alpha helices one side of the sheet and two alpha helices on the other, forming a three-layer (alpha beta alpha) sandwich.
469:
2291:
982:"Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis"
1166:
1986:
1490:
578:
This particular protein is an octamer made up of 8 identical subunits. Each monomer consists of a central domain and a C-terminal
2094:
1847:
1445:
206:
2127:
2060:
2007:
1450:
2065:
1877:
1852:
1440:
1334:
133:
1646:
1457:
1283:
383:
157:
1070:"The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway"
2260:
2172:
1862:
1159:
2200:
2085:
639:
635:
631:
627:
623:
619:
615:
611:
607:
603:
1303:
1278:
1263:
1223:
1425:
1420:
1393:
1631:
1339:
1298:
1258:
1248:
1243:
1228:
554:. It is vital for living organisms since it catalyses a step in the purine biosynthesis pathway which aids energy
1901:
1747:
1734:
1721:
1708:
1695:
1682:
1669:
1415:
1354:
1325:
1208:
1199:
319:
1641:
1308:
1233:
1218:
2296:
2253:
2167:
1595:
1538:
1190:
461:
415:
151:
44:
1288:
1268:
1253:
1213:
371:
2187:
1931:
1890:
1543:
495:, to be specific those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The
138:
1759:
1313:
1293:
1273:
1906:
1405:
465:
439:
2301:
2141:
2036:
1564:
1483:
1435:
481:
218:
1636:
367:
126:
2182:
1363:
1028:
824:"Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase"
312:
61:
324:
2159:
2132:
2002:
1600:
1113:"Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase"
477:
56:
865:"Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway"
154:
1973:
1832:
1796:
1533:
1140:
595:
78:
2286:
2012:
1942:
1814:
1132:
1099:
1056:
1003:
968:
925:
886:
845:
801:
752:
599:
504:
430:
358:
145:
2237:
1151:
2017:
1579:
1574:
1548:
1476:
1368:
1124:
1089:
1081:
1046:
1036:
993:
958:
950:
915:
876:
835:
791:
783:
742:
732:
511:
350:
1626:
1610:
1523:
559:
523:
496:
114:
1032:
534:
lack a salvage pathway for adenine nucleotides and rely entirely on the SAICAR pathway.
90:
2214:
2177:
2107:
2070:
1664:
1605:
1410:
1094:
1069:
796:
771:
747:
720:
501:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)
418:
396:
189:
49:
998:
981:
963:
938:
920:
903:
881:
864:
169:
2280:
2022:
1957:
1916:
1836:
1569:
1528:
1051:
1016:
304:
164:
1144:
268:
1518:
527:
346:
1085:
954:
510:
This particular protein family is of huge importance as it is found in all three
280:
1742:
1677:
1513:
579:
473:
173:
2209:
2055:
1801:
1792:
787:
583:
555:
543:
519:
407:
1112:
1716:
1690:
518:
biosynthesis. Purines are vital to all cells as they are involved in energy
485:
426:
1136:
1103:
1041:
929:
890:
849:
840:
823:
805:
756:
737:
436:
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
1060:
1007:
972:
308:
239:
547:
275:
33:
Phosphoribosylaminoimidazole succinocarboxamide synthetase oktamer, Human
551:
292:
287:
121:
102:
1128:
2233:
2230:
1804:
1729:
1499:
1373:
1186:
1182:
531:
515:
492:
422:
403:
378:
201:
97:
85:
73:
1703:
1383:
770:
Cheng X, Lu G, Qi J, Cheng H, Gao F, Wang J, et al. (2010).
700:
5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase
2145:
2136:
1398:
1388:
340:
263:
109:
1763:
1472:
1155:
28:
939:"Identification of the purC gene product of Escherichia coli"
1468:
652:
phosphoribosylaminoimidazole-succinocarboxamide synthetase
582:. The central domain consists of a five-stranded parallel
694:
phosphoribosylaminoimidazolesuccinocarboxamide synthetase
443:
244:
Structural genomics, protein TM1243, (SAICAR synthetase)
2241:
1873:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
1111:
Nelson SW, Binkowski DJ, Honzatko RB, Fromm HJ (2005).
822:
Ginder ND, Binkowski DJ, Fromm HJ, Honzatko RB (2006).
721:"Purine biosynthesis in archaea: variations on a theme"
412:
phosphoribosylaminoimidazolesuccinocarboxamide synthase
470:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
2198:
442:
863:
Mathews II, Kappock TJ, Stubbe J, Ealick SE (1999).
670:
4-(N-succinocarboxamide)-5-aminoimidazole synthetase
2158:
2120:
2044:
2035:
1995:
1972:
1927:
1886:
1829:
1822:
1813:
1655:
1619:
1588:
1557:
1506:
1353:
1324:
1198:
377:
357:
339:
334:
318:
298:
286:
274:
262:
254:
249:
232:
212:
200:
188:
183:
163:
144:
132:
120:
108:
96:
84:
72:
67:
55:
43:
38:
21:
719:Brown AM, Hoopes SL, White RH, Sarisky CA (2011).
514:of life. It is the seventh step in the pathway of
448:
402:is an enzyme which catalyses a reaction to create
598:have been solved for this class of enzymes, with
1068:O'Donnell AF, Tiong S, Nash D, Clark DV (2000).
1982:Hypoxanthine-guanine phosphoribosyltransferase
817:
815:
2261:
1775:
1484:
1167:
8:
1858:Phosphoribosylglycinamide formyltransferase
2268:
2254:
2048:
2041:
1826:
1819:
1782:
1768:
1760:
1491:
1477:
1469:
1174:
1160:
1152:
331:
238:
180:
1093:
1050:
1040:
997:
962:
919:
880:
839:
795:
746:
736:
441:
1868:Phosphoribosylaminoimidazole carboxylase
2205:
711:
229:
18:
1239:D-alanine—poly(phosphoribitol) ligase
491:This enzyme belongs to the family of
7:
2226:
2224:
2091:Orotidine 5'-phosphate decarboxylase
1015:Chen ZD, Dixon JE, Zalkin H (1990).
449:{\displaystyle \rightleftharpoons }
2240:. You can help Knowledge (XXG) by
1379:Von Hippel–Lindau tumor suppressor
676:4--5-aminoimidazole ribonucleotide
14:
1987:Adenine phosphoribosyltransferase
456:ADP + phosphate + (S)-2-succinate
2208:
2095:Uridine monophosphate synthetase
1848:Ribose-phosphate diphosphokinase
1345:Long-chain-fatty-acid—CoA ligase
542:This protein domain is found in
503:. This enzyme participates in
410:, this enzyme is also known as
27:
2128:Dihydropyrimidine dehydrogenase
2061:Carbamoyl phosphate synthase II
2008:Purine nucleoside phosphorylase
902:LUKENS LN, BUCHANAN JM (1959).
2066:Aspartate carbamoyltransferase
1853:Amidophosphoribosyltransferase
1441:Carbamoyl phosphate synthetase
1335:Succinyl coenzyme A synthetase
1:
2173:Nucleoside-diphosphate kinase
1863:AIR synthetase (FGAM cyclase)
999:10.1016/S0021-9258(18)47560-6
955:10.1128/JB.157.3.712-717.1984
921:10.1016/S0021-9258(18)69929-6
882:10.1016/S0969-2126(00)80029-5
335:Available protein structures:
2086:Dihydroorotate dehydrogenase
1021:Proc. Natl. Acad. Sci. U.S.A
980:Ebbole DJ, Zalkin H (1987).
530:drugs. This is because most
1086:10.1093/genetics/154.3.1239
2318:
2292:Enzymes of known structure
2223:
1426:Holocarboxylase synthetase
1421:Argininosuccinate synthase
1394:Anaphase-promoting complex
395:In molecular biology, the
2103:
2081:
2051:
1902:Adenylosuccinate synthase
1647:Michaelis–Menten kinetics
1458:Glutamate–cysteine ligase
1416:Adenylosuccinate synthase
1209:Aminoacyl tRNA synthetase
788:10.1107/S1744309110020518
330:
237:
179:
26:
2168:Ribonucleotide reductase
1539:Diffusion-limited enzyme
574:Protein domain structure
499:of this enzyme class is
2188:Dihydrofolate reductase
566:Protein domain function
488:, and (S)-2-succinate.
2236:-related article is a
1907:Adenylosuccinate lyase
1406:Glutathione synthetase
1042:10.1073/pnas.87.8.3097
841:10.1074/jbc.M602109200
738:10.1186/1745-6150-6-63
450:
2142:Beta-ureidopropionase
2037:Pyrimidine metabolism
1797:amino acid metabolism
1632:Eadie–Hofstee diagram
1565:Allosteric regulation
1436:Asparagine synthetase
1340:Acetyl—CoA synthetase
451:
2183:Thymidylate synthase
2160:Deoxyribonucleotides
1642:Lineweaver–Burk plot
1364:Glutamine synthetase
594:As of late 2007, 10
440:
2133:Dihydropyrimidinase
2003:Adenosine deaminase
1033:1990PNAS...87.3097C
464:of this enzyme are
1974:Nucleotide salvage
1601:Enzyme superfamily
1534:Enzyme promiscuity
776:Acta Crystallogr F
646:Other common names
590:Structural studies
446:
2249:
2248:
2196:
2195:
2154:
2153:
2116:
2115:
2031:
2030:
2013:Guanine deaminase
1968:
1967:
1943:IMP dehydrogenase
1815:Purine metabolism
1757:
1756:
1466:
1465:
1357:: Carbon-Nitrogen
1129:10.1021/bi048191w
937:Parker J (1984).
664:SAICAR synthetase
505:purine metabolism
431:chemical reaction
393:
392:
389:
388:
384:structure summary
233:SAICAR synthetase
228:
227:
224:
223:
127:metabolic pathway
2309:
2270:
2263:
2256:
2225:
2213:
2212:
2204:
2049:
2042:
2018:Xanthine oxidase
1936:
1895:
1841:
1827:
1820:
1784:
1777:
1770:
1761:
1637:Hanes–Woolf plot
1580:Enzyme activator
1575:Enzyme inhibitor
1549:Enzyme catalysis
1493:
1486:
1479:
1470:
1369:Ubiquitin ligase
1176:
1169:
1162:
1153:
1148:
1107:
1097:
1064:
1054:
1044:
1011:
1001:
976:
966:
933:
923:
895:
894:
884:
875:(11): 1395–406.
860:
854:
853:
843:
819:
810:
809:
799:
782:(Pt 8): 909–12.
767:
761:
760:
750:
740:
716:
602:accession codes
528:chemotherapeutic
476:, whereas its 3
455:
453:
452:
447:
332:
242:
230:
181:
31:
19:
16:Class of enzymes
2317:
2316:
2312:
2311:
2310:
2308:
2307:
2306:
2297:Protein domains
2277:
2276:
2275:
2274:
2221:
2219:
2207:
2199:
2197:
2192:
2150:
2112:
2099:
2077:
2027:
1991:
1964:
1928:
1923:
1887:
1882:
1830:
1809:
1788:
1758:
1753:
1665:Oxidoreductases
1651:
1627:Enzyme kinetics
1615:
1611:List of enzymes
1584:
1553:
1524:Catalytic triad
1502:
1497:
1467:
1462:
1349:
1328:: Carbon-Sulfur
1320:
1202:: Carbon-Oxygen
1194:
1185:: CO CS and CN
1180:
1110:
1067:
1027:(8): 3097–101.
1014:
992:(17): 8274–87.
979:
936:
914:(7): 1799–805.
901:
898:
862:
861:
857:
834:(30): 20680–8.
821:
820:
813:
769:
768:
764:
718:
717:
713:
709:
648:
592:
576:
568:
540:
497:systematic name
438:
437:
400:SAICAR synthase
245:
34:
22:SAICAR synthase
17:
12:
11:
5:
2315:
2313:
2305:
2304:
2299:
2294:
2289:
2279:
2278:
2273:
2272:
2265:
2258:
2250:
2247:
2246:
2218:
2217:
2194:
2193:
2191:
2190:
2185:
2180:
2178:DCMP deaminase
2175:
2170:
2164:
2162:
2156:
2155:
2152:
2151:
2149:
2148:
2139:
2130:
2124:
2122:
2118:
2117:
2114:
2113:
2111:
2110:
2108:CTP synthetase
2104:
2101:
2100:
2098:
2097:
2088:
2082:
2079:
2078:
2076:
2075:
2074:
2073:
2071:Dihydroorotase
2068:
2063:
2052:
2046:
2039:
2033:
2032:
2029:
2028:
2026:
2025:
2020:
2015:
2010:
2005:
1999:
1997:
1993:
1992:
1990:
1989:
1984:
1978:
1976:
1970:
1969:
1966:
1965:
1963:
1962:
1961:
1960:
1950:
1945:
1939:
1937:
1925:
1924:
1922:
1921:
1920:
1919:
1909:
1904:
1898:
1896:
1884:
1883:
1881:
1880:
1875:
1870:
1865:
1860:
1855:
1850:
1844:
1842:
1824:
1817:
1811:
1810:
1808:
1807:
1799:
1789:
1787:
1786:
1779:
1772:
1764:
1755:
1754:
1752:
1751:
1738:
1725:
1712:
1699:
1686:
1673:
1659:
1657:
1653:
1652:
1650:
1649:
1644:
1639:
1634:
1629:
1623:
1621:
1617:
1616:
1614:
1613:
1608:
1603:
1598:
1592:
1590:
1589:Classification
1586:
1585:
1583:
1582:
1577:
1572:
1567:
1561:
1559:
1555:
1554:
1552:
1551:
1546:
1541:
1536:
1531:
1526:
1521:
1516:
1510:
1508:
1504:
1503:
1498:
1496:
1495:
1488:
1481:
1473:
1464:
1463:
1461:
1460:
1455:
1454:
1453:
1448:
1438:
1433:
1428:
1423:
1418:
1413:
1411:CTP synthetase
1408:
1403:
1402:
1401:
1396:
1391:
1386:
1381:
1376:
1366:
1360:
1358:
1351:
1350:
1348:
1347:
1342:
1337:
1331:
1329:
1322:
1321:
1319:
1318:
1317:
1316:
1311:
1306:
1301:
1296:
1291:
1286:
1281:
1276:
1271:
1266:
1261:
1256:
1251:
1246:
1241:
1236:
1231:
1226:
1221:
1216:
1205:
1203:
1196:
1195:
1181:
1179:
1178:
1171:
1164:
1156:
1150:
1149:
1108:
1080:(3): 1239–53.
1065:
1012:
977:
934:
897:
896:
855:
811:
762:
710:
708:
705:
704:
703:
697:
691:
685:
679:
673:
667:
661:
655:
647:
644:
591:
588:
575:
572:
567:
564:
539:
538:Protein domain
536:
458:
457:
445:
397:protein domain
391:
390:
387:
386:
381:
375:
374:
361:
355:
354:
344:
337:
336:
328:
327:
322:
316:
315:
302:
296:
295:
290:
284:
283:
278:
272:
271:
266:
260:
259:
256:
252:
251:
247:
246:
243:
235:
234:
226:
225:
222:
221:
216:
210:
209:
204:
198:
197:
192:
186:
185:
177:
176:
167:
161:
160:
149:
142:
141:
136:
130:
129:
124:
118:
117:
112:
106:
105:
100:
94:
93:
88:
82:
81:
76:
70:
69:
65:
64:
59:
53:
52:
47:
41:
40:
36:
35:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2314:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2284:
2282:
2271:
2266:
2264:
2259:
2257:
2252:
2251:
2245:
2243:
2239:
2235:
2232:
2227:
2222:
2216:
2211:
2206:
2202:
2189:
2186:
2184:
2181:
2179:
2176:
2174:
2171:
2169:
2166:
2165:
2163:
2161:
2157:
2147:
2143:
2140:
2138:
2134:
2131:
2129:
2126:
2125:
2123:
2119:
2109:
2106:
2105:
2102:
2096:
2092:
2089:
2087:
2084:
2083:
2080:
2072:
2069:
2067:
2064:
2062:
2059:
2058:
2057:
2054:
2053:
2050:
2047:
2043:
2040:
2038:
2034:
2024:
2023:Urate oxidase
2021:
2019:
2016:
2014:
2011:
2009:
2006:
2004:
2001:
2000:
1998:
1994:
1988:
1985:
1983:
1980:
1979:
1977:
1975:
1971:
1959:
1958:GMP reductase
1956:
1955:
1954:
1951:
1949:
1946:
1944:
1941:
1940:
1938:
1935:
1933:
1926:
1918:
1917:AMP deaminase
1915:
1914:
1913:
1910:
1908:
1905:
1903:
1900:
1899:
1897:
1894:
1892:
1885:
1879:
1876:
1874:
1871:
1869:
1866:
1864:
1861:
1859:
1856:
1854:
1851:
1849:
1846:
1845:
1843:
1840:
1838:
1834:
1828:
1825:
1821:
1818:
1816:
1812:
1806:
1803:
1800:
1798:
1794:
1791:
1790:
1785:
1780:
1778:
1773:
1771:
1766:
1765:
1762:
1749:
1745:
1744:
1739:
1736:
1732:
1731:
1726:
1723:
1719:
1718:
1713:
1710:
1706:
1705:
1700:
1697:
1693:
1692:
1687:
1684:
1680:
1679:
1674:
1671:
1667:
1666:
1661:
1660:
1658:
1654:
1648:
1645:
1643:
1640:
1638:
1635:
1633:
1630:
1628:
1625:
1624:
1622:
1618:
1612:
1609:
1607:
1606:Enzyme family
1604:
1602:
1599:
1597:
1594:
1593:
1591:
1587:
1581:
1578:
1576:
1573:
1571:
1570:Cooperativity
1568:
1566:
1563:
1562:
1560:
1556:
1550:
1547:
1545:
1542:
1540:
1537:
1535:
1532:
1530:
1529:Oxyanion hole
1527:
1525:
1522:
1520:
1517:
1515:
1512:
1511:
1509:
1505:
1501:
1494:
1489:
1487:
1482:
1480:
1475:
1474:
1471:
1459:
1456:
1452:
1449:
1447:
1444:
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1442:
1439:
1437:
1434:
1432:
1429:
1427:
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1409:
1407:
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1397:
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1380:
1377:
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1371:
1370:
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1327:
1323:
1315:
1312:
1310:
1307:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1285:
1284:Phenylalanine
1282:
1280:
1277:
1275:
1272:
1270:
1267:
1265:
1262:
1260:
1257:
1255:
1252:
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1207:
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1201:
1197:
1192:
1188:
1184:
1177:
1172:
1170:
1165:
1163:
1158:
1157:
1154:
1146:
1142:
1138:
1134:
1130:
1126:
1123:(2): 766–74.
1122:
1118:
1114:
1109:
1105:
1101:
1096:
1091:
1087:
1083:
1079:
1075:
1071:
1066:
1062:
1058:
1053:
1048:
1043:
1038:
1034:
1030:
1026:
1022:
1018:
1013:
1009:
1005:
1000:
995:
991:
987:
986:J. Biol. Chem
983:
978:
974:
970:
965:
960:
956:
952:
948:
944:
940:
935:
931:
927:
922:
917:
913:
909:
908:J. Biol. Chem
905:
900:
899:
892:
888:
883:
878:
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866:
859:
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851:
847:
842:
837:
833:
829:
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798:
793:
789:
785:
781:
777:
773:
766:
763:
758:
754:
749:
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739:
734:
730:
726:
722:
715:
712:
706:
701:
698:
695:
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689:
686:
683:
680:
677:
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671:
668:
665:
662:
659:
656:
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641:
637:
633:
629:
625:
621:
617:
613:
609:
605:
601:
597:
589:
587:
585:
581:
573:
571:
565:
563:
561:
560:DNA synthesis
557:
553:
549:
545:
537:
535:
533:
529:
525:
524:DNA synthesis
521:
517:
513:
508:
506:
502:
498:
494:
489:
487:
483:
479:
475:
471:
467:
463:
435:
434:
433:
432:
428:
424:
420:
417:
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409:
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401:
398:
385:
382:
380:
376:
373:
369:
365:
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329:
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321:
317:
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297:
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285:
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279:
277:
273:
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220:
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208:
205:
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199:
196:
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187:
182:
178:
175:
171:
168:
166:
165:Gene Ontology
162:
159:
156:
153:
150:
147:
143:
140:
137:
135:
131:
128:
125:
123:
119:
116:
113:
111:
107:
104:
103:NiceZyme view
101:
99:
95:
92:
89:
87:
83:
80:
77:
75:
71:
66:
63:
60:
58:
54:
51:
48:
46:
42:
37:
30:
25:
20:
2302:Ligase stubs
2242:expanding it
2228:
2220:
1952:
1948:GMP synthase
1929:
1911:
1888:
1878:IMP synthase
1872:
1831:
1743:Translocases
1740:
1727:
1714:
1701:
1688:
1678:Transferases
1675:
1662:
1519:Binding site
1431:GMP synthase
1120:
1117:Biochemistry
1116:
1077:
1073:
1024:
1020:
989:
985:
949:(3): 712–7.
946:
943:J. Bacteriol
942:
911:
907:
872:
868:
858:
831:
827:
779:
775:
765:
728:
724:
714:
699:
693:
687:
681:
675:
669:
663:
657:
651:
593:
577:
569:
541:
509:
500:
490:
459:
421:). It is an
411:
399:
394:
91:BRENDA entry
1514:Active site
828:J Biol Chem
725:Biol Direct
580:alpha helix
474:L-aspartate
258:SAICAR_synt
250:Identifiers
79:IntEnz view
39:Identifiers
2281:Categories
2121:Catabolism
1996:Catabolism
1802:nucleotide
1793:Metabolism
1717:Isomerases
1691:Hydrolases
1558:Regulation
1304:Tryptophan
1279:Methionine
1264:Isoleucine
1224:Asparagine
707:References
682:synthetase
596:structures
584:beta sheet
556:metabolism
544:eukaryotes
520:metabolism
462:substrates
408:enzymology
347:structures
148:structures
115:KEGG entry
62:9023-67-0
2045:Anabolism
1823:Anabolism
1596:EC number
1299:Threonine
1259:Histidine
1249:Glutamine
1244:Glutamate
1229:Aspartate
869:Structure
486:phosphate
444:⇌
427:catalyzes
293:PDOC00810
281:IPR001636
68:Databases
2287:EC 6.3.2
1620:Kinetics
1544:Cofactor
1507:Activity
1309:Tyrosine
1234:Cysteine
1219:Arginine
1193:6.1-6.3)
1145:41673787
1137:15641804
1104:10757766
1074:Genetics
930:13672967
891:10574791
850:16687397
806:20693665
757:22168471
548:bacteria
478:products
364:RCSB PDB
276:InterPro
219:proteins
207:articles
195:articles
152:RCSB PDB
2215:Biology
1953:reverse
1912:reverse
1805:enzymes
1730:Ligases
1500:Enzymes
1289:Proline
1269:Leucine
1254:Glycine
1214:Alanine
1187:ligases
1183:Enzymes
1095:1460979
1061:1691501
1029:Bibcode
1008:3036807
973:6365889
797:2917288
748:3261824
688:SAICARs
552:archaea
532:cancers
512:domains
493:ligases
419:6.3.2.6
325:cd00476
288:PROSITE
269:PF01259
174:QuickGO
139:profile
122:MetaCyc
57:CAS no.
50:6.3.2.6
2234:enzyme
2231:EC 6.3
2201:Portal
1704:Lyases
1374:Cullin
1314:Valine
1294:Serine
1274:Lysine
1143:
1135:
1102:
1092:
1059:
1049:
1006:
971:
964:215316
961:
928:
889:
848:
804:
794:
755:
745:
731:: 63.
638:, and
516:purine
472:, and
460:The 3
423:enzyme
404:SAICAR
379:PDBsum
353:
343:
313:SUPFAM
255:Symbol
202:PubMed
184:Search
170:AmiGO
158:PDBsum
98:ExPASy
86:BRENDA
74:IntEnz
45:EC no.
2229:This
1656:Types
1384:UBE3A
1141:S2CID
1052:53841
425:that
406:. In
309:SCOPe
300:SCOP2
134:PRIAM
2238:stub
2146:UPB1
2137:DPYS
1930:IMP→
1889:IMP→
1748:list
1741:EC7
1735:list
1728:EC6
1722:list
1715:EC5
1709:list
1702:EC4
1696:list
1689:EC3
1683:list
1676:EC2
1670:list
1663:EC1
1399:UBR1
1389:Mdm2
1133:PMID
1100:PMID
1057:PMID
1004:PMID
969:PMID
926:PMID
887:PMID
846:PMID
802:PMID
753:PMID
658:PurC
640:2H31
636:2GQS
632:2GQR
628:2CNV
624:2CNU
620:2CNQ
616:1OBG
612:1OBD
608:1KUT
604:1A48
558:and
550:and
522:and
480:are
429:the
372:PDBj
368:PDBe
351:ECOD
341:Pfam
305:1a48
264:Pfam
214:NCBI
155:PDBe
110:KEGG
2056:CAD
1932:GMP
1891:AMP
1837:IMP
1833:R5P
1355:6.3
1326:6.2
1200:6.1
1125:doi
1090:PMC
1082:doi
1078:154
1047:PMC
1037:doi
994:doi
990:262
959:PMC
951:doi
947:157
916:doi
912:234
877:doi
836:doi
832:281
792:PMC
784:doi
743:PMC
733:doi
600:PDB
482:ADP
466:ATP
359:PDB
320:CDD
190:PMC
146:PDB
2283::
1795::
1451:II
1191:EC
1139:.
1131:.
1121:44
1119:.
1115:.
1098:.
1088:.
1076:.
1072:.
1055:.
1045:.
1035:.
1025:87
1023:.
1019:.
1002:.
988:.
984:.
967:.
957:.
945:.
941:.
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910:.
906:.
885:.
871:.
867:.
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830:.
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814:^
800:.
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780:66
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642:.
634:,
630:,
626:,
622:,
618:,
614:,
610:,
606:,
562:.
546:,
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484:,
468:,
416:EC
370:;
366:;
349:/
311:/
307:/
172:/
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2203::
2144:/
2135:/
2093:/
1934::
1893::
1839::
1835:→
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1746:(
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1733:(
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1720:(
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1707:(
1698:)
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735::
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414:(
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