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Pilomatricoma

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Hybrid cysts that are composed of epidermal inclusion cysts and pilomatricoma-like changes have been repeatedly observed in Gardner syndrome. This association has prognostic import, since cutaneous findings in children with Gardner syndrome generally precede
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Urabe, Kazunori; Xia, Jianxin; Masuda, Teiichi; Moroi, Yoichi; Furue, Masutaka; Matsumoto, Takayuki (2004). "Pilomatricoma-Like Changes in the Epidermoid Cysts of Gardner Syndrome with an APC Gene Mutation".
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gene or a stabilizing mutation in the beta-catenin gene, CTNNB1. A high level of beta-catenin increases cell proliferation, inhibits cell death, and ultimately leads to neoplastic growth.
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Levy, Jaime; Ilsar, Michael; Deckel, Yael; Maly, Alexander; Anteby, Irene; Pe'er, Jacob (2008). "Eyelid Pilomatrixoma: A Description of 16 cases and a Review of the Literature".
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RĂĽtten, A.; Wenzel, P.; Goos, M. (1990). "Gardner-Syndrom mit pilomatrixomartigen Haarfollikelzysten" [Gardner syndrome with pilomatrixoma-like hair follicle cysts].
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cytoplasm, well defined cell borders and a central clear area, but only faint traces of nuclear material), which in turn may transition into keratinaceous to amorphous
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Narisawa, Yutaka; Kohda, Hiromu (1989). "An Unusual Hybrid Cyst in Gardner's Syndrome with Partial Differentiation toward the Inner Root Sheath".
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are relatively uncommon and typically occur on the scalp, face, and upper extremities. Clinically, pilomatricomas present as a subcutaneous
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of a pilomatricoma showing the characteristic "ghost" cells (anucleate squamous cells), benign viable squamous cells and multi-nucleated
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with unremarkable overlying epidermis that can range in size from 0.5 to 3.0 cm, but the largest reported case was 24 cm.
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Cooper, Philip H.; Fechner, Robert E. (1983). "Pilomatricoma-like changes in the epidermal cysts of Gardner's syndrome".
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Narisawa, Yutaka; Kohda, Hiromu (1995). "Cutaneous cysts of Gardner's syndrome are similar to follicular stem cells".
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Glanz, Steven M.; Kessler, Harvey P.; Eskin, Thomas A.; Liu, Chen; Hassanein, Ashraf M. (2003).
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of fibrovascular connective tissue surrounding irregularly shaped, lobulated islands containing
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Der Hautarzt; Zeitschrift fĂĽr Dermatologie, Venerologie, und Verwandte Gebiete
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Pilomatricomas have been observed in a variety of genetic disorders including
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James, William Daniel; Berger, Timothy G.; Elston, Dirk M., eds. (2006).
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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Gongidi, P.; Meshekow, J.; Holdbrook, T.; Germaine, P. (2015).
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Atlas of Genetics and Cytogenetics in Oncology and Haematology
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List of cutaneous neoplasms associated with systemic syndromes
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The characteristic components of a pilomatricoma include a
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Andrews' Diseases of the Skin: Clinical Dermatology
75: 26: 21: 230:Pilomatricoma is associated with high levels of 446: 444: 415:Journal of the American Academy of Dermatology 805: 8: 1045: 846: 837: 812: 798: 790: 705: 86: 51: 18: 468: 389: 379: 171: 269: 457:American Journal of Clinical Pathology 63:of pilomatricoma, high magnification, 1190:Folliculosebaceous-apocrine hamartoma 7: 218:The presence of calcifications with 1185:Folliculosebaceous cystic hamartoma 1067:Multiple familial trichoepithelioma 234:caused by either a mutation in the 680:Lever's Histopathology of the Skin 630:10.1111/j.1346-8138.2004.tb00669.x 586:10.1111/j.1600-0560.1995.tb01392.x 506:10.1111/j.1346-8138.1989.tb01591.x 306:. Saunders Elsevier. p. 670. 14: 341:10.1016/j.survophthal.2008.06.007 1147:Tumor of follicular infundibulum 1119:Giant solitary trichoepithelioma 1114:Proliferating trichilemmal cyst 914:Syringocystadenoma papilliferum 41:Malherbe calcifying epithelioma 1233:Cutaneous congenital anomalies 1077:Desmoplastic trichoepithelioma 659:Punnya V Angadi (2009-06-01). 574:Journal of Cutaneous Pathology 1: 1180:Basaloid follicular hamartoma 1082:Generalized trichoepithelioma 678:Elder, David E., ed. (2014). 427:10.1016/S0190-9622(83)70071-X 222:is common within the tumors. 253:List of cutaneous conditions 1249: 1072:Solitary trichoepithelioma 961:Hidradenoma or Acrospiroma 618:The Journal of Dermatology 494:The Journal of Dermatology 1142: 1048: 859:Papillary eccrine adenoma 368:Case Reports in Radiology 279:Dermatology: 2-Volume Set 146:Rubinstein–Taybi syndrome 59: 50: 1212:Neoplasms of the nailbed 1017:Sebaceous nevus syndrome 929:Apocrine gland carcinoma 470:10.1309/EALEG7LD6W7167PX 220:foreign-body giant cells 205:(having abundant, pale, 1162:Birt–Hogg–DubĂ© syndrome 1057:Malignant pilomatricoma 329:Survey of Ophthalmology 248:Malignant pilomatricoma 1157:Perifollicular fibroma 1109:Trichilemmal carcinoma 184: 1022:Sebaceous hyperplasia 919:Papillary hidradenoma 884:Malignant acrospiroma 825:associated structures 661:"Skin: Pilomatricoma" 175: 281:. St. Louis: Mosby. 1002:Sebaceous carcinoma 997:Muir–Torre syndrome 874:Syringofibroadenoma 381:10.1155/2015/590742 168:Histologic features 970:Ceruminous adenoma 965:Hidradenocarcinoma 764:External resources 185: 142:myotonic dystrophy 1220: 1219: 1198: 1197: 1129:Trichofolliculoma 1062:Trichoepithelioma 1035: 1034: 1007:Sebaceous adenoma 978: 977: 907:Dermal cylindroma 864:Eccrine carcinoma 787: 786: 689:978-1-4511-9037-3 313:978-0-8089-2351-0 288:978-1-4160-2999-1 162:colonic polyposis 107:derived from the 95: 94: 16:Medical condition 1240: 1152:Fibrofolliculoma 1099:Fibrofolliculoma 1046: 847: 838: 814: 807: 800: 791: 706: 694: 693: 675: 669: 668: 656: 650: 649: 612: 606: 605: 569: 563: 562: 557: 532: 526: 525: 489: 483: 482: 472: 448: 439: 438: 410: 404: 403: 393: 383: 359: 353: 352: 324: 318: 317: 299: 293: 292: 274: 183:. H&E stain. 154:Gardner syndrome 91: 90: 55: 19: 1248: 1247: 1243: 1242: 1241: 1239: 1238: 1237: 1223: 1222: 1221: 1216: 1194: 1166: 1138: 1031: 992:Nevus sebaceous 984:Sebaceous gland 974: 938: 888: 827: 818: 788: 783: 782: 778:article/1058965 759: 758: 717: 703: 698: 697: 690: 677: 676: 672: 658: 657: 653: 614: 613: 609: 571: 570: 566: 555: 534: 533: 529: 491: 490: 486: 450: 449: 442: 412: 411: 407: 361: 360: 356: 326: 325: 321: 314: 301: 300: 296: 289: 276: 275: 271: 266: 244: 228: 170: 138:Turner syndrome 134: 129: 85: 17: 12: 11: 5: 1246: 1244: 1236: 1235: 1225: 1224: 1218: 1217: 1215: 1214: 1208: 1206: 1200: 1199: 1196: 1195: 1193: 1192: 1187: 1182: 1176: 1174: 1168: 1167: 1165: 1164: 1159: 1154: 1149: 1143: 1140: 1139: 1137: 1136: 1131: 1126: 1121: 1116: 1111: 1106: 1101: 1096: 1094:Trichoblastoma 1091: 1086: 1085: 1084: 1079: 1074: 1069: 1059: 1049: 1043: 1037: 1036: 1033: 1032: 1030: 1029: 1024: 1019: 1014: 1009: 1004: 999: 994: 988: 986: 980: 979: 976: 975: 973: 972: 967: 958: 952: 950: 940: 939: 937: 936: 934:Apocrine nevus 931: 926: 921: 916: 911: 910: 909: 898: 896: 890: 889: 887: 886: 881: 876: 871: 866: 861: 855: 853: 844: 835: 829: 828: 819: 817: 816: 809: 802: 794: 785: 784: 781: 780: 768: 767: 765: 761: 760: 757: 756: 745: 734: 718: 713: 712: 710: 709:Classification 702: 701:External links 699: 696: 695: 688: 670: 651: 624:(3): 255–257. 607: 580:(2): 115–121. 564: 543:(6): 326–328. 527: 500:(6): 492–495. 484: 440: 421:(5): 639–644. 405: 354: 319: 312: 294: 287: 268: 267: 265: 262: 261: 260: 255: 250: 243: 240: 227: 224: 195:basaloid cells 169: 166: 133: 130: 128: 125: 93: 92: 79: 73: 72: 61:Histopathology 57: 56: 48: 47: 28: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 1245: 1234: 1231: 1230: 1228: 1213: 1210: 1209: 1207: 1205: 1201: 1191: 1188: 1186: 1183: 1181: 1178: 1177: 1175: 1173: 1169: 1163: 1160: 1158: 1155: 1153: 1150: 1148: 1145: 1144: 1141: 1135: 1132: 1130: 1127: 1125: 1124:Trichoadenoma 1122: 1120: 1117: 1115: 1112: 1110: 1107: 1105: 1104:Trichilemmoma 1102: 1100: 1097: 1095: 1092: 1090: 1089:Trichodiscoma 1087: 1083: 1080: 1078: 1075: 1073: 1070: 1068: 1065: 1064: 1063: 1060: 1058: 1054: 1053:Pilomatricoma 1051: 1050: 1047: 1044: 1042: 1038: 1028: 1025: 1023: 1020: 1018: 1015: 1013: 1010: 1008: 1005: 1003: 1000: 998: 995: 993: 990: 989: 987: 985: 981: 971: 968: 966: 962: 959: 957: 954: 953: 951: 949: 945: 941: 935: 932: 930: 927: 925: 922: 920: 917: 915: 912: 908: 905: 904: 903: 900: 899: 897: 895: 891: 885: 882: 880: 877: 875: 872: 870: 869:Eccrine nevus 867: 865: 862: 860: 857: 856: 854: 852: 848: 845: 843: 839: 836: 834: 830: 826: 822: 815: 810: 808: 803: 801: 796: 795: 792: 779: 775: 774: 770: 769: 766: 762: 755: 751: 750: 746: 744: 740: 739: 735: 733: 729: 728: 724: 720: 719: 716: 711: 707: 700: 691: 685: 681: 674: 671: 666: 662: 655: 652: 647: 643: 639: 635: 631: 627: 623: 619: 611: 608: 603: 599: 595: 591: 587: 583: 579: 575: 568: 565: 560: 554: 550: 546: 542: 539:(in German). 538: 531: 528: 523: 519: 515: 511: 507: 503: 499: 495: 488: 485: 480: 476: 471: 466: 462: 458: 454: 447: 445: 441: 436: 432: 428: 424: 420: 416: 409: 406: 401: 397: 392: 387: 382: 377: 373: 369: 365: 358: 355: 350: 346: 342: 338: 335:(5): 526–35. 334: 330: 323: 320: 315: 309: 305: 298: 295: 290: 284: 280: 273: 270: 263: 259: 256: 254: 251: 249: 246: 245: 241: 239: 237: 233: 225: 223: 221: 216: 214: 213: 208: 204: 200: 196: 192: 191: 182: 178: 174: 167: 165: 163: 157: 155: 151: 147: 143: 139: 131: 126: 124: 122: 118: 114: 110: 106: 103: 99: 98:Pilomatricoma 89: 83: 80: 78: 74: 70: 66: 65:H&E stain 62: 58: 54: 49: 46: 45:Pilomatrixoma 42: 38: 36: 33: 29: 25: 22:Pilomatricoma 20: 1134:Dilated pore 1052: 924:Hidrocystoma 771: 747: 736: 721: 679: 673: 664: 654: 621: 617: 610: 577: 573: 567: 540: 536: 530: 497: 493: 487: 463:(5): 732–6. 460: 456: 418: 414: 408: 371: 367: 357: 332: 328: 322: 303: 297: 278: 272: 232:beta-catenin 229: 226:Pathogenesis 217: 210: 207:eosinophilic 202: 194: 189: 186: 158: 135: 132:Associations 127:Presentation 100:is a benign 97: 96: 44: 40: 30: 879:Spiradenoma 842:Sweat gland 203:ghost cells 181:giant cells 109:hair matrix 69:ghost cells 37:of Malherbe 35:epithelioma 27:Other names 902:Cylindroma 749:DiseasesDB 374:: 590742. 264:References 177:Micrograph 32:Calcifying 1172:Hamartoma 1027:Mantleoma 1012:Sebaceoma 956:Syringoma 773:eMedicine 199:cytoplasm 150:trisomy 9 113:neoplasms 77:Specialty 1227:Category 948:apocrine 894:Apocrine 646:29916492 638:15187352 559:19291018 522:11344468 479:14608900 400:25763287 349:18929763 242:See also 212:necrosis 111:. These 82:Oncology 944:Eccrine 851:Eccrine 743:D018296 602:5572492 594:7560342 549:2380070 514:2628457 435:6863619 391:4339831 833:Glands 821:Tumors 686:  644:  636:  600:  592:  556:  547:  520:  512:  477:  433:  398:  388:  347:  310:  285:  190:stroma 152:, and 117:nodule 84:  43:, and 1204:Nails 754:32128 642:S2CID 598:S2CID 553:INIST 518:S2CID 105:tumor 1041:Hair 823:and 738:MeSH 684:ISBN 634:PMID 590:PMID 545:PMID 510:PMID 475:PMID 431:PMID 396:PMID 372:2015 345:PMID 308:ISBN 283:ISBN 121:cyst 102:skin 732:D23 723:ICD 626:doi 582:doi 502:doi 465:doi 461:120 423:doi 386:PMC 376:doi 337:doi 236:APC 119:or 1229:: 776:: 752:: 741:: 730:: 727:10 663:. 640:. 632:. 622:31 620:. 596:. 588:. 578:22 576:. 551:. 541:41 516:. 508:. 498:16 496:. 473:. 459:. 455:. 443:^ 429:. 417:. 394:. 384:. 370:. 366:. 343:. 333:53 331:. 215:. 164:. 148:, 144:, 140:, 39:, 1055:/ 963:/ 946:/ 813:e 806:t 799:v 725:- 715:D 692:. 667:. 648:. 628:: 604:. 584:: 561:. 524:. 504:: 481:. 467:: 437:. 425:: 419:8 402:. 378:: 351:. 339:: 316:. 291:. 71:.

Index

Calcifying
epithelioma

Histopathology
H&E stain
ghost cells
Specialty
Oncology
Edit this on Wikidata
skin
tumor
hair matrix
neoplasms
nodule
cyst
Turner syndrome
myotonic dystrophy
Rubinstein–Taybi syndrome
trisomy 9
Gardner syndrome
colonic polyposis

Micrograph
giant cells
stroma
cytoplasm
eosinophilic
necrosis
foreign-body giant cells
beta-catenin

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