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Pilomatricoma

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Hybrid cysts that are composed of epidermal inclusion cysts and pilomatricoma-like changes have been repeatedly observed in Gardner syndrome. This association has prognostic import, since cutaneous findings in children with Gardner syndrome generally precede
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Urabe, Kazunori; Xia, Jianxin; Masuda, Teiichi; Moroi, Yoichi; Furue, Masutaka; Matsumoto, Takayuki (2004). "Pilomatricoma-Like Changes in the Epidermoid Cysts of Gardner Syndrome with an APC Gene Mutation".
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gene or a stabilizing mutation in the beta-catenin gene, CTNNB1. A high level of beta-catenin increases cell proliferation, inhibits cell death, and ultimately leads to neoplastic growth.
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Levy, Jaime; Ilsar, Michael; Deckel, Yael; Maly, Alexander; Anteby, Irene; Pe'er, Jacob (2008). "Eyelid Pilomatrixoma: A Description of 16 cases and a Review of the Literature".
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RĂĽtten, A.; Wenzel, P.; Goos, M. (1990). "Gardner-Syndrom mit pilomatrixomartigen Haarfollikelzysten" [Gardner syndrome with pilomatrixoma-like hair follicle cysts].
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cytoplasm, well defined cell borders and a central clear area, but only faint traces of nuclear material), which in turn may transition into keratinaceous to amorphous
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Narisawa, Yutaka; Kohda, Hiromu (1989). "An Unusual Hybrid Cyst in Gardner's Syndrome with Partial Differentiation toward the Inner Root Sheath".
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are relatively uncommon and typically occur on the scalp, face, and upper extremities. Clinically, pilomatricomas present as a subcutaneous
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of a pilomatricoma showing the characteristic "ghost" cells (anucleate squamous cells), benign viable squamous cells and multi-nucleated
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with unremarkable overlying epidermis that can range in size from 0.5 to 3.0 cm, but the largest reported case was 24 cm.
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Cooper, Philip H.; Fechner, Robert E. (1983). "Pilomatricoma-like changes in the epidermal cysts of Gardner's syndrome".
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Narisawa, Yutaka; Kohda, Hiromu (1995). "Cutaneous cysts of Gardner's syndrome are similar to follicular stem cells".
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Glanz, Steven M.; Kessler, Harvey P.; Eskin, Thomas A.; Liu, Chen; Hassanein, Ashraf M. (2003).
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of fibrovascular connective tissue surrounding irregularly shaped, lobulated islands containing
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Der Hautarzt; Zeitschrift fĂĽr Dermatologie, Venerologie, und Verwandte Gebiete
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Pilomatricomas have been observed in a variety of genetic disorders including
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James, William Daniel; Berger, Timothy G.; Elston, Dirk M., eds. (2006).
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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Gongidi, P.; Meshekow, J.; Holdbrook, T.; Germaine, P. (2015).
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Atlas of Genetics and Cytogenetics in Oncology and Haematology
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List of cutaneous neoplasms associated with systemic syndromes
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The characteristic components of a pilomatricoma include a
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Andrews' Diseases of the Skin: Clinical Dermatology
86: 37: 32: 241:Pilomatricoma is associated with high levels of 457: 455: 426:Journal of the American Academy of Dermatology 816: 8: 1056: 857: 848: 823: 809: 801: 716: 97: 62: 29: 479: 400: 390: 182: 280: 468:American Journal of Clinical Pathology 74:of pilomatricoma, high magnification, 1201:Folliculosebaceous-apocrine hamartoma 7: 229:The presence of calcifications with 1196:Folliculosebaceous cystic hamartoma 1078:Multiple familial trichoepithelioma 245:caused by either a mutation in the 691:Lever's Histopathology of the Skin 641:10.1111/j.1346-8138.2004.tb00669.x 597:10.1111/j.1600-0560.1995.tb01392.x 517:10.1111/j.1346-8138.1989.tb01591.x 317:. Saunders Elsevier. p. 670. 25: 352:10.1016/j.survophthal.2008.06.007 1158:Tumor of follicular infundibulum 1130:Giant solitary trichoepithelioma 1125:Proliferating trichilemmal cyst 925:Syringocystadenoma papilliferum 52:Malherbe calcifying epithelioma 1244:Cutaneous congenital anomalies 1088:Desmoplastic trichoepithelioma 670:Punnya V Angadi (2009-06-01). 585:Journal of Cutaneous Pathology 1: 1191:Basaloid follicular hamartoma 1093:Generalized trichoepithelioma 689:Elder, David E., ed. (2014). 438:10.1016/S0190-9622(83)70071-X 233:is common within the tumors. 264:List of cutaneous conditions 1260: 1083:Solitary trichoepithelioma 972:Hidradenoma or Acrospiroma 629:The Journal of Dermatology 505:The Journal of Dermatology 1153: 1059: 870:Papillary eccrine adenoma 379:Case Reports in Radiology 290:Dermatology: 2-Volume Set 157:Rubinstein–Taybi syndrome 70: 61: 1223:Neoplasms of the nailbed 1028:Sebaceous nevus syndrome 940:Apocrine gland carcinoma 481:10.1309/EALEG7LD6W7167PX 231:foreign-body giant cells 216:(having abundant, pale, 1173:Birt–Hogg–DubĂ© syndrome 1068:Malignant pilomatricoma 340:Survey of Ophthalmology 259:Malignant pilomatricoma 1168:Perifollicular fibroma 1120:Trichilemmal carcinoma 195: 1033:Sebaceous hyperplasia 930:Papillary hidradenoma 895:Malignant acrospiroma 836:associated structures 672:"Skin: Pilomatricoma" 186: 292:. St. Louis: Mosby. 1013:Sebaceous carcinoma 1008:Muir–Torre syndrome 885:Syringofibroadenoma 392:10.1155/2015/590742 179:Histologic features 981:Ceruminous adenoma 976:Hidradenocarcinoma 775:External resources 196: 153:myotonic dystrophy 1231: 1230: 1209: 1208: 1140:Trichofolliculoma 1073:Trichoepithelioma 1046: 1045: 1018:Sebaceous adenoma 989: 988: 918:Dermal cylindroma 875:Eccrine carcinoma 798: 797: 700:978-1-4511-9037-3 324:978-0-8089-2351-0 299:978-1-4160-2999-1 173:colonic polyposis 118:derived from the 106: 105: 27:Medical condition 16:(Redirected from 1251: 1163:Fibrofolliculoma 1110:Fibrofolliculoma 1057: 858: 849: 825: 818: 811: 802: 717: 705: 704: 686: 680: 679: 667: 661: 660: 623: 617: 616: 580: 574: 573: 568: 543: 537: 536: 500: 494: 493: 483: 459: 450: 449: 421: 415: 414: 404: 394: 370: 364: 363: 335: 329: 328: 310: 304: 303: 285: 194:. H&E stain. 165:Gardner syndrome 102: 101: 66: 30: 21: 1259: 1258: 1254: 1253: 1252: 1250: 1249: 1248: 1234: 1233: 1232: 1227: 1205: 1177: 1149: 1042: 1003:Nevus sebaceous 995:Sebaceous gland 985: 949: 899: 838: 829: 799: 794: 793: 789:article/1058965 770: 769: 728: 714: 709: 708: 701: 688: 687: 683: 669: 668: 664: 625: 624: 620: 582: 581: 577: 566: 545: 544: 540: 502: 501: 497: 461: 460: 453: 423: 422: 418: 372: 371: 367: 337: 336: 332: 325: 312: 311: 307: 300: 287: 286: 282: 277: 255: 239: 181: 149:Turner syndrome 145: 140: 96: 28: 23: 22: 15: 12: 11: 5: 1257: 1255: 1247: 1246: 1236: 1235: 1229: 1228: 1226: 1225: 1219: 1217: 1211: 1210: 1207: 1206: 1204: 1203: 1198: 1193: 1187: 1185: 1179: 1178: 1176: 1175: 1170: 1165: 1160: 1154: 1151: 1150: 1148: 1147: 1142: 1137: 1132: 1127: 1122: 1117: 1112: 1107: 1105:Trichoblastoma 1102: 1097: 1096: 1095: 1090: 1085: 1080: 1070: 1060: 1054: 1048: 1047: 1044: 1043: 1041: 1040: 1035: 1030: 1025: 1020: 1015: 1010: 1005: 999: 997: 991: 990: 987: 986: 984: 983: 978: 969: 963: 961: 951: 950: 948: 947: 945:Apocrine nevus 942: 937: 932: 927: 922: 921: 920: 909: 907: 901: 900: 898: 897: 892: 887: 882: 877: 872: 866: 864: 855: 846: 840: 839: 830: 828: 827: 820: 813: 805: 796: 795: 792: 791: 779: 778: 776: 772: 771: 768: 767: 756: 745: 729: 724: 723: 721: 720:Classification 713: 712:External links 710: 707: 706: 699: 681: 662: 635:(3): 255–257. 618: 591:(2): 115–121. 575: 554:(6): 326–328. 538: 511:(6): 492–495. 495: 451: 432:(5): 639–644. 416: 365: 330: 323: 305: 298: 279: 278: 276: 273: 272: 271: 266: 261: 254: 251: 238: 235: 206:basaloid cells 180: 177: 144: 141: 139: 136: 104: 103: 90: 84: 83: 72:Histopathology 68: 67: 59: 58: 39: 35: 34: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 1256: 1245: 1242: 1241: 1239: 1224: 1221: 1220: 1218: 1216: 1212: 1202: 1199: 1197: 1194: 1192: 1189: 1188: 1186: 1184: 1180: 1174: 1171: 1169: 1166: 1164: 1161: 1159: 1156: 1155: 1152: 1146: 1143: 1141: 1138: 1136: 1135:Trichoadenoma 1133: 1131: 1128: 1126: 1123: 1121: 1118: 1116: 1115:Trichilemmoma 1113: 1111: 1108: 1106: 1103: 1101: 1100:Trichodiscoma 1098: 1094: 1091: 1089: 1086: 1084: 1081: 1079: 1076: 1075: 1074: 1071: 1069: 1065: 1064:Pilomatricoma 1062: 1061: 1058: 1055: 1053: 1049: 1039: 1036: 1034: 1031: 1029: 1026: 1024: 1021: 1019: 1016: 1014: 1011: 1009: 1006: 1004: 1001: 1000: 998: 996: 992: 982: 979: 977: 973: 970: 968: 965: 964: 962: 960: 956: 952: 946: 943: 941: 938: 936: 933: 931: 928: 926: 923: 919: 916: 915: 914: 911: 910: 908: 906: 902: 896: 893: 891: 888: 886: 883: 881: 880:Eccrine nevus 878: 876: 873: 871: 868: 867: 865: 863: 859: 856: 854: 850: 847: 845: 841: 837: 833: 826: 821: 819: 814: 812: 807: 806: 803: 790: 786: 785: 781: 780: 777: 773: 766: 762: 761: 757: 755: 751: 750: 746: 744: 740: 739: 735: 731: 730: 727: 722: 718: 711: 702: 696: 692: 685: 682: 677: 673: 666: 663: 658: 654: 650: 646: 642: 638: 634: 630: 622: 619: 614: 610: 606: 602: 598: 594: 590: 586: 579: 576: 571: 565: 561: 557: 553: 550:(in German). 549: 542: 539: 534: 530: 526: 522: 518: 514: 510: 506: 499: 496: 491: 487: 482: 477: 473: 469: 465: 458: 456: 452: 447: 443: 439: 435: 431: 427: 420: 417: 412: 408: 403: 398: 393: 388: 384: 380: 376: 369: 366: 361: 357: 353: 349: 346:(5): 526–35. 345: 341: 334: 331: 326: 320: 316: 309: 306: 301: 295: 291: 284: 281: 274: 270: 267: 265: 262: 260: 257: 256: 252: 250: 248: 244: 236: 234: 232: 227: 225: 224: 219: 215: 211: 207: 203: 202: 193: 189: 185: 178: 176: 174: 168: 166: 162: 158: 154: 150: 142: 137: 135: 133: 129: 125: 121: 117: 114: 110: 109:Pilomatricoma 100: 94: 91: 89: 85: 81: 77: 76:H&E stain 73: 69: 65: 60: 57: 56:Pilomatrixoma 53: 49: 47: 44: 40: 36: 33:Pilomatricoma 31: 19: 18:Pilomatrixoma 1145:Dilated pore 1063: 935:Hidrocystoma 782: 758: 747: 732: 690: 684: 675: 665: 632: 628: 621: 588: 584: 578: 551: 547: 541: 508: 504: 498: 474:(5): 732–6. 471: 467: 429: 425: 419: 382: 378: 368: 343: 339: 333: 314: 308: 289: 283: 243:beta-catenin 240: 237:Pathogenesis 228: 221: 218:eosinophilic 213: 205: 200: 197: 169: 146: 143:Associations 138:Presentation 111:is a benign 108: 107: 55: 51: 41: 890:Spiradenoma 853:Sweat gland 214:ghost cells 192:giant cells 120:hair matrix 80:ghost cells 48:of Malherbe 46:epithelioma 38:Other names 913:Cylindroma 760:DiseasesDB 385:: 590742. 275:References 188:Micrograph 43:Calcifying 1183:Hamartoma 1038:Mantleoma 1023:Sebaceoma 967:Syringoma 784:eMedicine 210:cytoplasm 161:trisomy 9 124:neoplasms 88:Specialty 1238:Category 959:apocrine 905:Apocrine 657:29916492 649:15187352 570:19291018 533:11344468 490:14608900 411:25763287 360:18929763 253:See also 223:necrosis 122:. These 93:Oncology 955:Eccrine 862:Eccrine 754:D018296 613:5572492 605:7560342 560:2380070 525:2628457 446:6863619 402:4339831 844:Glands 832:Tumors 697:  655:  647:  611:  603:  567:  558:  531:  523:  488:  444:  409:  399:  358:  321:  296:  201:stroma 163:, and 128:nodule 95:  54:, and 1215:Nails 765:32128 653:S2CID 609:S2CID 564:INIST 529:S2CID 116:tumor 1052:Hair 834:and 749:MeSH 695:ISBN 645:PMID 601:PMID 556:PMID 521:PMID 486:PMID 442:PMID 407:PMID 383:2015 356:PMID 319:ISBN 294:ISBN 132:cyst 113:skin 743:D23 734:ICD 637:doi 593:doi 513:doi 476:doi 472:120 434:doi 397:PMC 387:doi 348:doi 247:APC 130:or 1240:: 787:: 763:: 752:: 741:: 738:10 674:. 651:. 643:. 633:31 631:. 607:. 599:. 589:22 587:. 562:. 552:41 527:. 519:. 509:16 507:. 484:. 470:. 466:. 454:^ 440:. 428:. 405:. 395:. 381:. 377:. 354:. 344:53 342:. 226:. 175:. 159:, 155:, 151:, 50:, 1066:/ 974:/ 957:/ 824:e 817:t 810:v 736:- 726:D 703:. 678:. 659:. 639:: 615:. 595:: 572:. 535:. 515:: 492:. 478:: 448:. 436:: 430:8 413:. 389:: 362:. 350:: 327:. 302:. 82:. 20:)

Index

Pilomatrixoma
Calcifying
epithelioma

Histopathology
H&E stain
ghost cells
Specialty
Oncology
Edit this on Wikidata
skin
tumor
hair matrix
neoplasms
nodule
cyst
Turner syndrome
myotonic dystrophy
Rubinstein–Taybi syndrome
trisomy 9
Gardner syndrome
colonic polyposis

Micrograph
giant cells
stroma
cytoplasm
eosinophilic
necrosis
foreign-body giant cells

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