391:
433:
InChI=1S/C57H89N19O21S2/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98-34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58/h16,19-21,23-27,31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60,80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H,75,90)(H2,61,73,76)/t23-,24+,25+,26-,27-,31-,32+,36-,37-,38-,39+,40+,41-,42-,43-,44-,45-,55+,56-/m0/s1
312:
29:
582:
Zheng JW, Yang XJ, Wang YA, He Y, Ye WM, Zhang ZY (October 2009). "Intralesional injection of
Pingyangmycin for vascular malformations in oral and maxillofacial regions: an evaluation of 297 consecutive patients".
189:)-2-{amino}-3-oxopropyl]-5-methyl-4-pyrimidinyl}carbonyl)amino]-3-{propyl}carbamoyl)-2,4'-bi-1,3-thiazol-2'-yl]ethyl}amino)-3-hydroxy-1-oxo-2-butanyl]amino}-3-hydroxy-4-methyl-5-oxo-2-pentanyl]amino}-1-(1
405:
413:
C(O)(NC(=O)(C)(O)(C)NC(=O)(NC(=O)c1nc(nc(N)c1C)(CC(N)=O)NC(N)C(N)=O)(O1O(CO)(O)(O)1O1O(CO)(O)(OC(N)=O)1O)c1ccn1)C(=O)NCCc1nc(cs1)-c1nc(cs1)C(=O)NCCCNCCCCN
506:(commonly known as "bleomycin"), since according to Chinese sources it is more effective, costs less, is easier to get, can treat a larger variety of
683:
678:
425:
161:
91:
280:
224:
534:, which is rare, but may happen even in a low dose, and can be fatal. In addition, it causes a higher incidence of
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49:
647:
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi
Kouqiang Yixue Zazhi = West China Journal of Stomatology
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than bleomycin; the occurrence of this complication in patients is between 20 and 50%.
672:
511:
300:
78:
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20:
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193:-imidazol-5-yl)-3-oxopropyl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2
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28:
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197:-pyran-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2
555:
Lin FT, Li DD, Yang XP, Li Q, Xue YC, Zhen YS (1979). "".
522:
injury. Though pingyangmycin and bleomycin can each cause
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In China, pingyangmycin has largely superseded bleomycin A
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Shou BQ, Mao Z, Zhang SL, Yang Z (October 2009). "".
16:
Glycopeptide antibiotic used to treat various cancers
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530:- which it does not share with bleomycin - is
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620:Yao Xue Xue Bao = Acta Pharmaceutica Sinica
99:In general: ℞ (Prescription only)
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618:Xu HZ, Zhang HY (October 1980). "".
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597:10.1016/j.oraloncology.2009.02.011
14:
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27:
526:, pingyangmycin's most serious
487:. It was discovered in 1969 at
438:Key:QYOAUOAXCQAEMW-UTXKDXHTSA-N
353:
347:
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1:
469:family, which is produced by
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684:DNA replication inhibitors
557:Zhonghua Zhong Liu Za Zhi
319:Chemical and physical data
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157:
26:
679:Glycopeptide antibiotics
484:Streptomyces verticillus
471:Streptomyces verticillus
463:glycopeptide antibiotic
201:-pyran-4-yl carbamate
475:pingyangensis n.sp.
23:
532:anaphylactic shock
524:pulmonary fibrosis
518:) and causes less
77:, intra-arterial,
493:Zhejiang Province
465:belonging to the
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392:Interactive image
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489:Pingyang County
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451:(also known as
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108:Pharmacokinetic
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626:(10): 609–14.
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591:(10): 872–6.
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585:Oral Oncology
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512:breast cancer
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449:Pingyangmycin
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302:ECHA InfoCard
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36:Clinical data
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21:Pingyangmycin
653:(5): 572–3.
650:
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623:
619:
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588:
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563:(3): 161–6.
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516:liver cancer
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128:Elimination
92:Legal status
86:Legal status
44:Bleomycin A5
528:side effect
453:bleomycin A
375: g·mol
308:100.031.221
153:Identifiers
75:intravenous
41:Other names
673:Categories
542:References
380:3D model (
364:Molar mass
290:5DY91Y7601
261:ChemSpider
225:55658-47-4
220:11116-32-8
211:CAS Number
162:IUPAC name
116:Metabolism
510:(such as
467:bleomycin
460:antitumor
141:Excretion
135:1.3 hours
130:half-life
68:Routes of
50:Pregnancy
659:19927737
605:19628423
458:) is an
148:(25-50%)
52:category
632:6167140
508:cancers
479:variety
325:Formula
270:8232875
236:PubChem
121:amidase
657:
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603:
567:
406:SMILES
569:95444
536:fever
497:China
426:InChI
382:JSmol
250:84046
146:renal
655:PMID
628:PMID
601:PMID
565:PMID
520:lung
514:and
477:, a
473:var.
281:UNII
110:data
593:doi
495:in
491:of
481:of
373:.57
371:440
240:CID
675::
651:27
649:.
624:15
622:.
599:.
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587:.
559:.
351:21
345:19
339:89
333:57
185:,6
181:,5
177:,4
173:,3
169:(2
661:.
634:.
607:.
595::
571:.
561:1
504:2
455:5
384:)
369:1
357:2
354:S
348:O
342:N
336:H
330:C
199:H
195:H
191:H
187:R
183:R
179:S
175:S
171:R
59:D
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