1421:
1322:
1210:
1155:
842:
787:
715:
609:
1474:
1255:
1093:
951:
893:
663:
539:
27:
320:
in males. PMCA types 2 and 3 are activated more quickly and are, therefore, better suited to excitable cell types such as those in nervous and muscle tissue, which experiences large influxes of Ca when excited. PMCA types 1, 2, and 4 have been found in
507:
Jensen, Thomas P.; Buckby, Lucy E.; Empson, Ruth M. (2004). "Expression of plasma membrane Ca ATPase family members and associated synaptic proteins in acute and cultured organotypic hippocampal slices from rat".
1223:
Graf, Ernst; Verma, Anil K.; Gorski, Jeffrey P.; Lopaschuk, Gary; Niggli, Verena; Zurini, Mauro; Carafoli, E.; Penniston, John T. (1982). "Molecular
Properties of Calcium-Pumping ATPase from Human Erythrocytes".
2168:
163:, so its levels must be kept low in cells to prevent noise and keep signalling accurate. The NCX is better suited for removing large amounts of Ca quickly, as is needed in
1435:
Penniston, John T.; Gfiloteo, Adelaida; McDonough, Carol S.; Carafoli, Ernesto (1988). "Purification, reconstitution, and regulation of plasma membrane Ca
373:
PMCA isoform 4 has a molecular weight of 134,683, calculated from its sequence. This is in good agreement with the results of SDS gel electrophoresis.
571:
Strehler, Emanuel E.; Zacharias, David A. (2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps".
381:
When the PMCA fails to function properly, disease can result. Improperly functioning PMCA proteins have been found associated with conditions such as
90:
Ca concentrations. Since it transports Ca into the extracellular space, the PMCA is also an important regulator of the calcium concentration in the
2861:
2161:
20:
1268:
VanHouten, Joshua; Sullivan, Catherine; Bazinet, Caroline; Ryoo, Tom; Camp, Robert; Rimm, David L.; Chung, Gina; Wysolmerski, John (2010-06-22).
2391:
1456:
1027:
985:
818:
2360:
1933:
196:
activity, since the PMCA is involved in regulating the amount of calcium within the cell at the synapse, and Ca is involved in release of
855:
Burette, Alain; Weinberg, Richard J. (February 2007). "Perisynaptic organization of plasma membrane calcium pumps in cerebellar cortex".
3048:
1547:
98:
1929:
2154:
1068:
1049:
329:
in mammals, though it was previously thought that only the NCX was present in glia. Astrocytes help to maintain ionic balance in the
1522:
301:
transcripts of these genes results in different subtypes of these isoforms. Over 20 splice variants have been identified so far.
236:
for PMCA pumps than for SERCA pumps. It is thought that the PMCA pump has 10 segments that cross the plasma membrane, with both
2951:
446:
lowers calcium levels inside malignant cells, allowing them to avoid apoptosis. These tumors are also usually positive for the
2946:
1500:
248:
in length. This tail is thought to be responsible for regulation of the pump. PMCA pumps have a molecular mass of around 140
454:, and are more common among young women, which could help explain their worse prognosis compared with postmenopausal women.
2968:
1274:
189:
20 to 30 times. Calmodulin also increases the rate at which the pump extrudes Ca from the cell, possibly up to tenfold.
3016:
1490:
510:
411:, resulting in excessive influx of Ca into cells, the activity of the PMCA may be insufficient to remove the excess Ca.
174:
The PMCA functions in a similar manner to other p-type ion pumps. ATP transfers a phosphate to the PMCA, which forms a
2938:
1531:
484:
was discovered in the membranes in 1961, and then in 1966 it was discovered that these ATPases pump Ca out of the
2997:
2538:
2436:
2261:
2257:
2234:
2207:
2194:
2181:
2136:
1896:
1891:
137:
2552:
2247:
2212:
2185:
1494:
148:
83:
63:
2922:
2885:
2224:
683:
Talarico, Ernest F. Jr.; Kennedy, Brian G.; Marfurt, Carl F.; Loeffler, Karin U.; Mangini, Nancy J. (2005).
175:
1420:
1335:
Shehzad, Adeeb; Shahzad, Raheem; Lee, Young Sup (2014-01-01), Bathaie, S. Zahra; Tamanoi, Fuyuhiko (eds.),
1321:
1209:
1154:
841:
786:
739:"Pre-synaptic plasma membrane isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3"
714:
608:
2652:
2292:
1989:
1473:
1254:
1226:
1113:"The plasmamembrane calmodulin–dependent calcium pump : a major regulator of nitric oxide synthase I"
1092:
1048:
Fresu, Luigia; Dehpour, Ahmed; Genazzani, Armando A.; Carafoli, Ernesto; Guerini, Danilo (November 1999).
950:
892:
685:"Expression and immunolocalization of plasma membrane calcium ATPase isoforms in human corneal epithelium"
662:
538:
465:
382:
229:
125:
151:, which has a low affinity and a high capacity. Thus, the PMCA is effective at binding Ca even when its
2782:
2690:
1381:"Purification of the (Ca-Mg) ATPase from Human Erythrocyte Membranes using a Calmodulin Affinity Column"
1336:
1007:
965:
461:
439:
359:
233:
136:
removed for each molecule of ATP hydrolysed. It binds tightly to Ca ions (has a high affinity, with a
1168:
Verma, Anil K.; Filoteo, Adelaida G.; Stanford, David R.; Wieben, Eric D.; Penniston, John T. (1988).
316:
do not survive. Lack of PMCA4, which is also very common in many tissues, is survivable, but leads to
1515:
1282:
2024:
2987:
330:
228:
calcium pumps, which are responsible for removing calcium from the cytoplasm into the lumen of the
213:
155:
within the cell are very low, so it is suited for maintaining Ca at its normally very low levels.
91:
87:
3002:
2568:
2146:
1441:
Biomembranes Part Q: ATP-Driven Pumps and
Related Transport: Calcium, Proton, and Potassium Pumps
1270:"PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer"
1081:
881:
597:
294:
156:
192:
In brain tissue, it has been postulated that certain types of PMCA are important for regulating
2242:
1462:
1452:
1403:
1356:
1310:
1243:
1192:
1143:
1073:
1023:
981:
939:
873:
824:
814:
769:
697:
651:
589:
527:
348:
43:
2123:
2118:
2103:
1791:
2632:
2578:
2560:
2426:
2416:
2370:
2087:
2081:
2076:
2054:
2044:
2034:
2001:
1883:
1878:
1868:
1649:
1589:
1444:
1393:
1348:
1300:
1290:
1235:
1182:
1133:
1125:
1063:
1015:
973:
929:
921:
865:
857:
759:
751:
643:
581:
519:
401:
309:
293:
Each isoform is coded by a different gene and is expressed in different areas of the body.
197:
168:
160:
105:
2445:
2065:
1905:
1900:
244:
on the inside of the cell. At the C terminus, there is a long "tail" of between 70 and 200
2979:
2868:
2682:
2382:
2202:
2013:
1839:
1535:
1508:
79:
75:
47:
1111:
Schuh, Kai; Uldrijan, Stjepan; Telkamp, Myriam; Röthlein, Nicola; Neyses, Ludwig (2001).
806:
1286:
200:. Additionally, it has been shown that PMCA activity is modulated and partly powered by
2302:
1937:
1921:
1385:
1352:
1305:
1269:
1174:
1138:
1112:
1054:
1019:
977:
934:
907:
764:
477:
397:
58:(Ca) from the cell. PMCA function is vital for regulating the amount of Ca within all
51:
1398:
1337:"Chapter Eight - Curcumin: A Potent Modulator of Multiple Enzymes in Multiple Cancers"
1187:
738:
523:
3042:
2846:
2456:
2017:
1829:
1448:
1117:
964:
Lopez, Jose R.; Allen, Paul D. (2012-01-01), Hill, Joseph A.; Olson, Eric N. (eds.),
635:
573:
443:
423:
336:
249:
152:
129:
71:
1085:
885:
2831:
2804:
2733:
2726:
2709:
2704:
2678:
1556:
1543:
1169:
912:
601:
390:
363:
344:
186:
1343:, Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids,
737:
Jensen, Thomas P.; Filoteo, Adelaida G.; Knopfel, Thomas; Empson, Ruth M. (2006).
647:
185:
binds and further activates the PMCA, increasing the affinity of the protein's Ca-
755:
585:
2927:
743:
427:
317:
925:
2912:
2601:
1006:
Edes, Istvan; Kranias, Evangelia G. (1995-01-01), Sperelakis, NICHOLAS (ed.),
451:
419:
322:
245:
241:
237:
201:
182:
121:
59:
2618:
2177:
1295:
828:
689:
435:
404:
340:
326:
209:
26:
1360:
1314:
1147:
1077:
943:
877:
773:
701:
593:
531:
1466:
1247:
1196:
1129:
813:(6th ed.). Philadelphia: Lippincott-Raven. ATP-Dependent Ca2+ Pumps.
655:
147:) but does not remove Ca at a very fast rate. This is in contrast to the
1997:
1796:
1786:
1781:
1766:
1761:
1756:
1746:
1741:
1736:
1726:
1721:
1711:
1706:
1701:
1696:
1677:
1669:
1565:
1407:
1069:
10.1002/(SICI)1098-1136(199911)28:2<150::AID-GLIA6>3.0.CO;2-7
457:
447:
386:
355:
144:
1239:
684:
3023:
2992:
2770:
2765:
2524:
2514:
2489:
2484:
2219:
2113:
2108:
1776:
1771:
1751:
1731:
1716:
1691:
1686:
1681:
966:"Chapter 56 - Control of Resting Ca2+ Concentration in Skeletal Muscle"
485:
431:
261:
193:
171:. Thus the activities of the two types of pump complement each other.
55:
869:
2900:
2542:
2519:
2509:
2479:
2474:
2469:
2464:
2421:
2411:
2406:
2401:
2396:
2365:
2353:
2348:
2343:
2338:
2326:
2321:
2316:
2265:
2097:
2092:
2071:
2049:
2039:
1976:
1971:
1966:
1961:
1956:
1951:
1946:
1941:
1913:
1873:
1863:
1858:
1853:
1848:
1843:
1813:
1803:
1639:
1619:
1614:
1609:
1604:
1584:
1574:
1539:
908:"Calcium clearance and its energy requirements in cerebellar neurons"
906:
Ivannikov, Maxim V.; Sugimori, Mutsuyuki; Llinás, Rodolfo R. (2010).
481:
415:
408:
367:
313:
286:
280:
274:
268:
205:
164:
2956:
2895:
2878:
2873:
2721:
2699:
2665:
2660:
2645:
2623:
2611:
2606:
2596:
2591:
2586:
2311:
2287:
2060:
1984:
1925:
1659:
1654:
1644:
1634:
1629:
1624:
1599:
1594:
1579:
305:
225:
109:
2961:
2917:
2905:
2890:
2856:
2851:
2836:
2819:
2814:
2809:
2797:
2792:
2787:
2777:
2753:
2748:
2743:
2738:
2640:
2028:
298:
2150:
1504:
1170:"Complete Primary Structure of a Human Plasma Membrane Ca Pump"
491:
PMCA was first purified from red blood cell membranes in 1979.
3011:
3007:
1379:
Niggli, Verena; Penniston, John T.; Carafoli, Ernesto (1979).
811:
308:
in varying distributions. PMCA1 is ubiquitous throughout all
133:
67:
476:
PMCAs were first discovered in the 1960s in the membranes of
633:
Carafoli, E. (1991). "Calcium pump of the plasma membrane".
70:
into cells, yet it is very important that they maintain low
304:
Three PMCA isoforms, PMCA1, PMCA2, and PMCA3, occur in the
1443:. Methods in Enzymology. Vol. 157. pp. 340–351.
1050:"Plasma membrane calcium ATPase isoforms in astrocytes"
1380:
972:, Boston/Waltham: Academic Press, pp. 801–810,
224:
The structure of the PMCA is similar to that of the
2977:
2936:
2676:
2550:
2537:
2502:
2454:
2435:
2381:
2301:
2280:
2273:
2256:
2233:
2193:
1828:
1812:
1668:
1564:
1555:
422:express PMCA2, which transports calcium across the
19:"PMCA" redirects here. For the protein assay, see
104:Various forms of PMCA are expressed in different
400:, a process in which excessive amounts of the
2162:
1516:
212:. Presumably, it is due to PMCA proximity to
101:which form aspartyl phosphate intermediates.
8:
1491:Plasma+Membrane+Calcium-Transporting+ATPases
809:. In Siegel, George J.; et al. (eds.).
805:Albers, R. Wayne; Siegel, George J. (1999).
78:. Thus, it is necessary for cells to employ
62:cells. There is a very large transmembrane
54:that functions as a calcium pump to remove
2547:
2277:
2270:
2169:
2155:
2147:
1561:
1523:
1509:
1501:
1281:(25) (published 2010-06-04): 11405–11410.
732:
730:
728:
726:
724:
678:
676:
674:
672:
628:
626:
624:
622:
620:
618:
566:
564:
562:
560:
558:
556:
554:
552:
550:
548:
86:(NCX) are together the main regulators of
1912:3.A.3.1.4: H/K transporting, nongastric:
1493:at the U.S. National Library of Medicine
1397:
1304:
1294:
1186:
1137:
1067:
933:
763:
442:. Persistent PMCA2 expression in certain
232:. Calcium tends to have a slightly lower
1106:
1104:
1102:
800:
798:
796:
25:
864:(6) (published 2006-12-20): 1127–1135.
499:
21:Protein misfolding cyclic amplification
1062:(2) (published 1999-10-22): 150–155.
7:
1014:, Academic Press, pp. 156–165,
99:P-type primary ion transport ATPases
82:to remove the Ca. The PMCA and the
1353:10.1016/b978-0-12-802215-3.00008-2
1020:10.1016/b978-0-12-656970-4.50019-1
978:10.1016/b978-0-12-381510-1.00056-9
264:of PMCA, called PMCA 1 through 4.
14:
1557:F-, V-, and A-type ATPase (3.A.2)
524:10.1016/j.devbrainres.2004.06.004
460:can bind to the PMCA, inducing a
1472:
1419:
1320:
1253:
1208:
1153:
1091:
949:
891:
840:
785:
713:
661:
607:
537:
358:. Isoform PMCA4b interacts with
1573:H transporting, mitochondrial:
66:of Ca driving the entry of the
97:PMCAs belong to the family of
1:
1399:10.1016/S0021-9258(19)86652-8
1275:Proc. Natl. Acad. Sci. U.S.A.
1188:10.1016/S0021-9258(18)68198-0
648:10.1152/physrev.1991.71.1.129
434:, leading to calcium-induced
30:Rendered image of the Ca pump
1449:10.1016/0076-6879(88)57089-1
756:10.1113/jphysiol.2006.123901
586:10.1152/physrev.2001.81.1.21
511:Developmental Brain Research
430:. PMCA2 expression falls on
2939:Protein-synthesizing GTPase
1347:, Academic Press: 149–174,
1012:Cell Physiology Source Book
120:The pump is powered by the
3065:
3049:Transmembrane transporters
1983:3.A.3.5: Cu transporting:
1532:Membrane transport protein
926:10.1016/j.ceca.2010.04.004
312:in humans, and without it
18:
2998:Guanylate-binding protein
2182:acid anhydride hydrolases
2132:
1678:H transporting, lysosomal
362:and reduces synthesis of
36:plasma membrane Ca ATPase
2553:Heterotrimeric G protein
2248:Phosphoadenylylsulfatase
1495:Medical Subject Headings
440:mammary gland involution
216:in the plasma membrane.
84:sodium calcium exchanger
64:electrochemical gradient
2225:Thiamine-triphosphatase
1296:10.1073/pnas.0911186107
807:"5. Membrane Transport"
450:, tend to involve the
383:sensorineural deafness
230:sarcoplasmic reticulum
126:adenosine triphosphate
31:
2980:Polymerization motors
2691:Rho family of GTPases
1130:10.1083/jcb.200104131
480:. The presence of an
462:conformational change
360:nitric oxide synthase
29:
343:problems, including
214:glucose transporters
2988:dynamin superfamily
2086:Class VI, type 11:
1287:2010PNAS..10711405V
1240:10.1021/bi00261a049
1181:(28): 14152–14159.
1008:"13 - Ca2+-ATPases"
331:extracellular space
92:extracellular space
2070:Class V, type 10:
2059:Class II, type 9:
426:of the cells into
347:and problems with
295:Alternate splicing
32:
3036:
3035:
3032:
3031:
2533:
2532:
2498:
2497:
2243:Adenylylsulfatase
2144:
2143:
2033:Class I, type 8:
1840:Na/K transporting
1824:
1823:
1458:978-0-12-182058-9
1392:(20): 9955–9958.
1234:(18): 4511–4516.
1029:978-0-12-656970-4
987:978-0-12-381510-1
870:10.1002/cne.21237
820:978-0-397-51820-3
198:synaptic vesicles
74:of Ca for proper
44:transport protein
16:Transport protein
3056:
2548:
2278:
2271:
2171:
2164:
2157:
2148:
2137:ATPase disorders
2008:Other/ungrouped:
1562:
1525:
1518:
1511:
1502:
1479:
1477:
1476:
1470:
1432:
1426:
1424:
1423:
1417:
1415:
1414:
1401:
1376:
1370:
1369:
1368:
1367:
1332:
1326:
1325:
1324:
1318:
1308:
1298:
1265:
1259:
1258:
1257:
1251:
1220:
1214:
1213:
1212:
1206:
1204:
1203:
1190:
1165:
1159:
1158:
1157:
1151:
1141:
1108:
1097:
1096:
1095:
1089:
1071:
1045:
1039:
1038:
1037:
1036:
1003:
997:
996:
995:
994:
961:
955:
954:
953:
947:
937:
903:
897:
896:
895:
889:
858:J. Comp. Neurol.
852:
846:
845:
844:
838:
836:
835:
802:
791:
790:
789:
783:
781:
780:
767:
734:
719:
718:
717:
711:
709:
708:
680:
667:
666:
665:
659:
630:
613:
612:
611:
605:
568:
543:
542:
541:
535:
504:
420:epithelial cells
418:tissue, mammary
402:neurotransmitter
354:PMCA4 exists in
339:of PMCA2 causes
169:action potential
161:second messenger
159:is an important
108:, including the
3064:
3063:
3059:
3058:
3057:
3055:
3054:
3053:
3039:
3038:
3037:
3028:
2973:
2932:
2683:Ras superfamily
2672:
2656:
2636:
2582:
2572:
2564:
2529:
2494:
2450:
2431:
2377:
2334:Plasma membrane
2297:
2252:
2229:
2203:Pyrophosphatase
2189:
2175:
2145:
2140:
2128:
2025:Mg transporting
1938:Ca transporting
1820:
1819:found in Archea
1808:
1664:
1551:
1529:
1487:
1482:
1471:
1459:
1438:
1434:
1433:
1429:
1418:
1412:
1410:
1378:
1377:
1373:
1365:
1363:
1334:
1333:
1329:
1319:
1267:
1266:
1262:
1252:
1222:
1221:
1217:
1207:
1201:
1199:
1167:
1166:
1162:
1152:
1110:
1109:
1100:
1090:
1047:
1046:
1042:
1034:
1032:
1030:
1005:
1004:
1000:
992:
990:
988:
963:
962:
958:
948:
905:
904:
900:
890:
854:
853:
849:
839:
833:
831:
821:
804:
803:
794:
784:
778:
776:
736:
735:
722:
712:
706:
704:
682:
681:
670:
660:
632:
631:
616:
606:
570:
569:
546:
536:
506:
505:
501:
497:
478:red blood cells
474:
379:
260:There are four
258:
222:
143:of 100 to 200 n
141:
118:
76:cell signalling
48:plasma membrane
24:
17:
12:
11:
5:
3062:
3060:
3052:
3051:
3041:
3040:
3034:
3033:
3030:
3029:
3027:
3026:
3021:
3020:
3019:
3014:
3005:
3000:
2995:
2984:
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2974:
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2971:
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2903:
2898:
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2881:
2876:
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2864:
2859:
2854:
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2841:
2840:
2839:
2834:
2824:
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2822:
2817:
2812:
2802:
2801:
2800:
2795:
2790:
2780:
2775:
2774:
2773:
2768:
2758:
2757:
2756:
2751:
2746:
2741:
2731:
2730:
2729:
2724:
2714:
2713:
2712:
2707:
2702:
2687:
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2250:
2245:
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1485:External links
1483:
1481:
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1457:
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1427:
1386:J. Biol. Chem.
1371:
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1175:J. Biol. Chem.
1160:
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642:(1): 129–153.
614:
544:
518:(2): 129–136.
498:
496:
493:
473:
470:
468:from binding.
464:that prevents
444:breast cancers
424:apical surface
398:excitotoxicity
378:
375:
333:in the brain.
291:
290:
284:
278:
272:
257:
254:
221:
218:
178:intermediate.
176:phosphorylated
153:concentrations
139:
128:(ATP), with a
117:
114:
72:concentrations
15:
13:
10:
9:
6:
4:
3:
2:
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2457:P-type ATPase
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1830:P-type ATPase
1827:
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1118:J. Cell Biol.
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766:
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749:
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733:
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725:
721:
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695:
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679:
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669:
664:
657:
653:
649:
645:
641:
638:
637:
636:Physiol. Rev.
629:
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623:
621:
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595:
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574:Physiol. Rev.
567:
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463:
459:
455:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
412:
410:
407:overactivate
406:
403:
399:
394:
392:
388:
384:
376:
374:
371:
369:
365:
361:
357:
352:
350:
346:
342:
338:
334:
332:
328:
324:
319:
315:
311:
307:
302:
300:
296:
288:
285:
282:
279:
276:
273:
270:
267:
266:
265:
263:
255:
253:
251:
247:
243:
239:
235:
231:
227:
219:
217:
215:
211:
207:
203:
199:
195:
190:
188:
184:
179:
177:
172:
170:
166:
162:
158:
154:
150:
146:
142:
135:
131:
130:stoichiometry
127:
123:
115:
113:
111:
107:
102:
100:
95:
93:
89:
88:intracellular
85:
81:
77:
73:
69:
65:
61:
57:
53:
49:
45:
41:
37:
28:
22:
2826:
2760:
2716:
2694:
2679:Small GTPase
2333:
2293:Wilson/ATP7B
2288:Menkes/ATP7A
2134:
1544:ATP synthase
1440:
1430:
1411:. Retrieved
1389:
1384:
1374:
1364:, retrieved
1344:
1340:
1330:
1278:
1273:
1263:
1231:
1227:Biochemistry
1225:
1218:
1200:. Retrieved
1178:
1173:
1163:
1121:
1116:
1059:
1053:
1043:
1033:, retrieved
1011:
1001:
991:, retrieved
969:
959:
917:
913:Cell Calcium
911:
901:
861:
856:
850:
832:. Retrieved
810:
777:. Retrieved
750:(1): 85–99.
747:
742:
705:. Retrieved
693:
688:
639:
634:
580:(1): 21–50.
577:
572:
515:
509:
502:
490:
475:
456:
448:HER2 protein
413:
395:
391:hypertension
380:
372:
364:nitric oxide
353:
345:hearing loss
335:
303:
292:
259:
223:
204:in neuronal
191:
187:binding site
180:
173:
119:
103:
96:
39:
35:
33:
3003:Mitofusin-1
2978:3.6.5.5-6:
2947:Prokaryotic
1996:3.A.3.8.8:
1890:3.A.3.1.2:
1838:3.A.3.1.1:
1341:The Enzymes
744:J. Physiol.
696:: 169–178.
452:lymph nodes
323:glial cells
318:infertility
246:amino acids
2969:Eukaryotic
2602:Transducin
2439:(3.6.3.10)
2178:Hydrolases
1670:H (V-type)
1566:H (F-type)
1548:TC 3A2-3A3
1413:2013-12-25
1366:2020-11-08
1202:2013-12-25
1035:2020-11-08
993:2020-11-08
834:2013-12-25
779:2007-01-13
707:2013-12-25
495:References
327:astrocytes
202:glycolysis
183:calmodulin
132:of one Ca
122:hydrolysis
60:eukaryotic
2937:3.6.5.3:
2677:3.6.5.2:
2619:Gustducin
2551:3.6.5.1:
2385:(3.6.3.9)
2305:(3.6.3.8)
2208:Inorganic
2135:see also
2102:type 13:
1920:3.A.3.2:
1536:ion pumps
1439:-pumps".
690:Mol. Vis.
436:apoptosis
405:glutamate
377:Pathology
341:inner ear
337:Knock-out
242:N termini
220:Structure
210:dendrites
167:after an
80:ion pumps
3043:Category
2213:Thiamine
1998:flippase
1814:A-ATPase
1797:ATP6V0E1
1787:ATP6V0D2
1782:ATP6V0D1
1767:ATP6V0A4
1762:ATP6V0A2
1757:ATP6V0A1
1747:ATP6V1G3
1742:ATP6V1G2
1737:ATP6V1G1
1727:ATP6V1E2
1722:ATP6V1E1
1712:ATP6V1C2
1707:ATP6V1C1
1702:ATP6V1B2
1697:ATP6V1B1
1361:27102703
1315:20534448
1148:11591728
1086:44343760
1078:10533058
944:20510449
886:22110231
878:17183553
829:39013748
774:17170045
702:15765049
594:11152753
532:15351500
458:Curcumin
387:diabetes
366:by that
356:caveolae
262:isoforms
256:Isoforms
234:affinity
194:synaptic
3024:Tubulin
2993:Dynamin
2845:other:
2525:Katanin
2515:Kinesin
2490:ATP13A3
2485:ATP13A2
2220:Apyrase
2124:ATP13A5
2119:ATP13A4
2114:ATP13A3
2109:ATP13A2
2104:ATP13A1
1832:(3.A.3)
1792:ATP6V0E
1777:ATP6V0C
1772:ATP6V0B
1752:ATP6V1H
1732:ATP6V1F
1717:ATP6V1D
1692:ATP6V1A
1687:ATP6AP2
1682:ATP6AP1
1540:ATPases
1467:2976465
1306:2895115
1283:Bibcode
1248:6215062
1197:2844759
1139:2198825
935:2900537
765:2075377
656:1986387
602:9062253
486:cytosol
472:History
432:weaning
409:neurons
349:balance
325:called
314:embryos
310:tissues
297:of the
289:- PMCA4
283:- PMCA3
277:- PMCA2
271:- PMCA1
165:neurons
157:Calcium
116:Actions
106:tissues
56:calcium
46:in the
42:) is a
2901:ARL13B
2761:RhoBTB
2655:α12/13
2543:GTPase
2520:Myosin
2510:Dynein
2480:ATP12A
2475:ATP11B
2470:ATP10A
2465:ATP8B1
2455:Other
2427:ATP1B4
2422:ATP1B3
2417:ATP1B2
2412:ATP1B1
2407:ATP1A4
2402:ATP1A3
2397:ATP1A2
2392:ATP1A1
2383:Na+/K+
2371:ATP2C2
2366:ATP2C1
2354:ATP2B4
2349:ATP2B3
2344:ATP2B2
2339:ATP2B1
2327:ATP2A3
2322:ATP2A2
2317:ATP2A1
2266:ATPase
2098:ATP11C
2093:ATP11B
2088:ATP11A
2082:ATP10D
2077:ATP10B
2072:ATP10A
2055:ATP8B4
2050:ATP8B3
2045:ATP8B2
2040:ATP8B1
2035:ATP8A1
2002:ATP8A2
1977:ATP2C1
1972:ATP2B4
1967:ATP2B3
1962:ATP2B2
1957:ATP2B1
1952:ATP2A3
1947:ATP2A2
1942:ATP2A1
1914:ATP12A
1884:ATP1G1
1879:ATP1B4
1874:ATP1B3
1869:ATP1B2
1864:ATP1B1
1859:ATP1A4
1854:ATP1A3
1849:ATP1A2
1844:ATP1A1
1804:TCIRG1
1650:ATP5L2
1640:ATP5J2
1620:ATP5G3
1615:ATP5G2
1610:ATP5G1
1605:ATP5F1
1590:ATP5C2
1585:ATP5C1
1575:ATP5A1
1497:(MeSH)
1465:
1455:
1408:158595
1406:
1359:
1313:
1303:
1246:
1195:
1146:
1136:
1084:
1076:
1026:
984:
970:Muscle
942:
932:
884:
876:
827:
817:
772:
762:
700:
654:
600:
592:
530:
482:ATPase
416:breast
389:, and
368:enzyme
287:ATP2B4
281:ATP2B3
275:ATP2B2
269:ATP2B1
206:somata
2957:EF-Tu
2896:SAR1B
2879:RAB27
2874:RAB23
2827:RhoDF
2717:RhoUV
2700:CDC42
2695:Cdc42
2681:>
2666:GNA13
2661:GNA12
2646:GNA11
2635:αq/11
2624:GNAT3
2612:GNAT2
2607:GNAT1
2597:GNAI3
2592:GNAI2
2587:GNAI1
2539:3.6.5
2503:3.6.4
2446:ATP4A
2437:H+/K+
2312:SERCA
2274:3.6.3
2258:3.6.3
2235:3.6.2
2195:3.6.1
2066:ATP9B
2061:ATP9A
1990:ATP7B
1985:ATP7A
1926:SERCA
1906:ATP4B
1901:ATP4A
1660:ATP5S
1655:ATP5O
1645:ATP5L
1635:ATP5J
1630:ATP5I
1625:ATP5H
1600:ATP5E
1595:ATP5D
1580:ATP5B
1082:S2CID
882:S2CID
598:S2CID
306:brain
226:SERCA
110:brain
52:cells
3017:OPA1
3010:and
2962:EF-G
2952:IF-2
2918:Rheb
2906:ARL6
2891:ARF6
2862:NRAS
2857:KRAS
2852:HRAS
2837:RhoD
2832:RhoF
2778:RhoH
2754:RhoG
2739:Rac1
2727:RhoV
2722:RhoU
2705:TC10
2641:GNAQ
2361:SPCA
2188:3.6)
2029:ATP3
2014:Na/K
1936:) /
1934:SPCA
1930:PMCA
1463:PMID
1453:ISBN
1404:PMID
1357:PMID
1311:PMID
1244:PMID
1193:PMID
1144:PMID
1074:PMID
1055:Glia
1024:ISBN
982:ISBN
940:PMID
874:PMID
825:OCLC
815:ISBN
770:PMID
698:PMID
652:PMID
590:PMID
528:PMID
438:and
428:milk
299:mRNA
240:and
208:and
40:PMCA
34:The
3012:MX2
3008:MX1
2928:RGK
2923:Rap
2913:Ran
2886:Arf
2869:Rab
2847:Ras
2805:Rnd
2783:Rho
2734:Rac
2710:TCL
2571:olf
2303:Ca+
1892:H/K
1445:doi
1394:doi
1390:254
1349:doi
1301:PMC
1291:doi
1279:107
1236:doi
1183:doi
1179:263
1134:PMC
1126:doi
1122:155
1064:doi
1016:doi
974:doi
930:PMC
922:doi
866:doi
862:500
760:PMC
752:doi
748:579
644:doi
582:doi
520:doi
516:152
466:ATP
414:In
396:In
250:kDa
181:Ca/
149:NCX
134:ion
124:of
68:ion
50:of
3045::
2693::
2581:αi
2563:αs
2541::
2264::
2186:EC
2180::
2027::
2016:–
2000::
1940::
1932:,
1928:,
1922:Ca
1899::
1842::
1680::
1542:/
1538:,
1534::
1461:.
1451:.
1402:.
1383:.
1355:,
1345:36
1339:,
1309:.
1299:.
1289:.
1272:.
1242:.
1232:21
1230:.
1191:.
1172:.
1142:.
1132:.
1115:.
1101:^
1080:.
1072:.
1060:28
1058:.
1052:.
1022:,
1010:,
980:,
968:,
938:.
928:.
918:47
916:.
910:.
880:.
872:.
823:.
795:^
768:.
758:.
741:.
723:^
694:11
687:.
671:^
650:.
640:71
617:^
596:.
588:.
578:81
547:^
526:.
514:.
488:.
393:.
385:,
370:.
351:.
252:.
112:.
94:.
2820:3
2815:2
2810:1
2798:C
2793:B
2788:A
2771:2
2766:1
2749:3
2744:2
2653:G
2633:G
2579:G
2569:G
2561:G
2262:4
2260:-
2184:(
2170:e
2163:t
2156:v
2018:H
1924:(
1550:)
1546:(
1524:e
1517:t
1510:v
1478:.
1469:.
1447::
1437:2
1425:.
1416:.
1396::
1351::
1317:.
1293::
1285::
1250:.
1238::
1205:.
1185::
1150:.
1128::
1088:.
1066::
1018::
976::
946:.
924::
888:.
868::
837:.
782:.
754::
710:.
658:.
646::
604:.
584::
534:.
522::
238:C
145:M
140:m
138:K
38:(
23:.
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