2595:
217:
gene that is switched on via SOS induction caused by stalled polymerases at the replication fork. During SOS induction, Pol IV production is increased tenfold and one of the functions during this time is to interfere with Pol III holoenzyme processivity. This creates a checkpoint, stops replication,
218:
and allows time to repair DNA lesions via the appropriate repair pathway. Another function of Pol IV is to perform translesion synthesis at the stalled replication fork like, for example, bypassing N2-deoxyguanine adducts at a faster rate than transversing undamaged DNA. Cells lacking
2122:
2132:
2127:
260:
mutation is produced (G:C → 8-oxoG:C → 8-oxoG:A → T:A). However, when DNA polymerase IV intervenes to bypass the damage, it preferentially incorporates the correct nucleotide
2247:
2225:
2043:
98:
145:
2153:
2048:
598:
2215:
1162:
1125:
1854:
1988:
1245:
2314:
1558:
1352:
1254:
820:
431:"The processivity factor beta controls DNA polymerase IV traffic during spontaneous mutagenesis and translesion synthesis in vivo"
1699:
1307:
237:
91:
31:
1167:
2470:
2272:
2267:
1827:
1645:
977:
827:
591:
2585:
2137:
2025:
1993:
1978:
1660:
968:
636:
611:
213:, DNA polymerase IV (Pol 4) is involved in non-targeted mutagenesis. Pol IV is a Family Y polymerase expressed by the
1097:
1073:
942:
774:
721:
703:
615:
2455:
2571:
2558:
2545:
2532:
2519:
2506:
2493:
2258:
2236:
2211:
2186:
2106:
1714:
1674:
1619:
1596:
1568:
1536:
1402:
1151:
2465:
1489:
264:
opposite 8-oxoguanine with high efficiency, thus avoiding potential mutations (G:C → 8-oxoG:C → 8-oxoG:C → GC).
2615:
2419:
2362:
1723:
1704:
1635:
1369:
1312:
584:
127:
54:
256:, unrepaired 8-oxoguanine tends to mispair with A, so that during the next round of replication a G:C to T:A
2367:
1581:
714:
645:
233:
2035:
1808:
1718:
1211:
1142:
2388:
2307:
1889:
1844:
1546:
1531:
1467:
1447:
1345:
1137:
906:
576:
341:"All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis"
280:
Kim SR, Maenhaut-Michel G, Yamada M, Yamamoto Y, Matsui K, Sofuni T, Nohmi T, Ohmori H (December 1997).
261:
2460:
1330:
1803:
1798:
1678:
1541:
1521:
1430:
1184:
1157:
1108:
2424:
2066:
2058:
1839:
1506:
1442:
1406:
914:
290:
results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA"
2357:
1929:
1867:
1818:
1553:
1380:
240:. DNA polymerase IV can catalyze translesion synthesis across a variety of DNA damages including
534:"Single-Molecule Investigation of Response to Oxidative DNA Damage by a Y-Family DNA Polymerase"
2620:
1944:
1934:
1924:
1849:
1792:
1778:
1773:
1511:
1474:
1120:
937:
563:
511:
460:
411:
370:
321:
390:"SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification"
2403:
2398:
2372:
2300:
2277:
1939:
1919:
1861:
1757:
1655:
1640:
1586:
1484:
1479:
1338:
1077:
926:
921:
813:
553:
545:
501:
491:
450:
442:
401:
360:
352:
311:
301:
2450:
2434:
2347:
2200:
2190:
2012:
1983:
1609:
1516:
1501:
1290:
1082:
956:
674:
624:
607:
165:
282:"Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of
132:
2599:
2488:
2429:
2168:
2007:
1914:
1906:
1783:
1746:
930:
910:
558:
533:
455:
430:
253:
506:
479:
406:
389:
365:
340:
2609:
2393:
2352:
1437:
1132:
1059:
669:
316:
281:
2342:
1526:
1496:
1425:
1271:
257:
241:
227:
103:
446:
480:"SOS-induced DNA polymerases enhance long-term survival and evolutionary fitness"
2566:
2501:
2337:
2092:
2082:
1683:
1420:
1361:
1216:
549:
206:
198:
191:
175:
2594:
356:
1894:
1737:
1650:
1415:
1365:
1302:
1276:
1064:
1049:
249:
194:
139:
110:
306:
2540:
2514:
2173:
2086:
1623:
1389:
1240:
1054:
1044:
567:
515:
496:
464:
415:
374:
388:
McKenzie GJ, Lee PL, Lombardo MJ, Hastings PJ, Rosenberg SM (March 2001).
325:
2020:
1600:
1317:
1298:
870:
861:
659:
245:
115:
1971:
1956:
1572:
881:
856:
851:
683:
222:
gene have a higher rate of mutagenesis caused by DNA damaging agents.
17:
2553:
2323:
1949:
1384:
86:
2527:
1966:
1961:
1813:
1231:
1226:
1221:
1204:
1199:
1194:
1189:
1177:
1172:
890:
885:
842:
837:
832:
2123:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
339:
Napolitano R, Janel-Bintz R, Wagner J, Fuchs RP (November 2000).
1877:
1872:
1768:
1763:
1462:
1457:
1452:
1113:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
874:
804:
799:
794:
789:
784:
779:
767:
760:
751:
746:
741:
736:
731:
726:
688:
664:
652:
2296:
1334:
580:
429:
Lenne-Samuel N, Wagner J, Etienne H, Fuchs RP (January 2002).
236:
are produced continuously during normal metabolism and these
2292:
478:
Yeiser B, Pepper ED, Goodman MF, Finkel SE (June 2002).
2583:
2133:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
209:(proofreading) activity and hence is error prone. In
2138:
CDP-diacylglycerol—choline O-phosphatidyltransferase
2479:
2443:
2412:
2381:
2330:
2257:
2235:
2210:
2185:
2166:
2146:
2128:
CDP-diacylglycerol—serine O-phosphatidyltransferase
2115:
2105:
2075:
2057:
2034:
2006:
1905:
1745:
1736:
1713:
1673:
1618:
1595:
1567:
1401:
1377:
1289:
1263:
1093:
964:
955:
899:
699:
632:
623:
171:
161:
156:
138:
126:
121:
109:
97:
85:
75:
65:
49:
44:
39:
30:"dinB" redirects here. For the kind of bank, see
532:Raper AT, Gadkari VV, Maxwell BA, Suo Z (2016).
527:
525:
2308:
1346:
592:
8:
2154:N-acetylglucosamine-1-phosphate transferase
2044:UTP—glucose-1-phosphate uridylyltransferase
2315:
2301:
2293:
2182:
2112:
1742:
1733:
1398:
1353:
1339:
1331:
961:
629:
599:
585:
577:
153:
2248:serine/threonine-specific protein kinases
2226:serine/threonine-specific protein kinases
2049:Galactose-1-phosphate uridylyltransferase
557:
505:
495:
454:
405:
364:
315:
305:
2590:
272:
36:
244:, a major oxidative damage with high
7:
25:
1559:Glucose-1,6-bisphosphate synthase
1255:Control of chromosome duplication
821:Autonomously replicating sequence
2593:
1700:Ribose-phosphate diphosphokinase
32:deposit insurance national bank
1:
2273:Protein-histidine tele-kinase
2268:Protein-histidine pros-kinase
2147:Glycosyl-1-phosphotransferase
978:DNA polymerase III holoenzyme
828:Single-strand binding protein
407:10.1016/s1097-2765(01)00204-0
1979:RNA-dependent RNA polymerase
484:Proc. Natl. Acad. Sci. U.S.A
294:Proc. Natl. Acad. Sci. U.S.A
1886:RNA-directed DNA polymerase
1754:DNA-directed DNA polymerase
550:10.1021/acs.biochem.6b00166
447:10.1093/embo-reports/kvf007
205:gene. It exhibits no 3′→5′
2637:
2239:: protein-dual-specificity
1074:Prokaryotic DNA polymerase
775:Minichromosome maintenance
722:Origin recognition complex
59:(str. K-12 substr. MG1655)
29:
2471:Michaelis–Menten kinetics
1152:Eukaryotic DNA polymerase
152:
2363:Diffusion-limited enzyme
2216:protein-serine/threonine
2116:Phosphatidyltransferases
1705:Thiamine diphosphokinase
357:10.1093/emboj/19.22.6259
307:10.1073/pnas.94.25.13792
715:Pre-replication complex
646:Pre-replication complex
254:replicative polymerases
234:Reactive oxygen species
2036:Nucleotidyltransferase
1719:nucleotidyltransferase
1646:Nucleoside-diphosphate
497:10.1073/pnas.092269199
226:Replication bypass of
201:and is encoded by the
146:genome: 0.25 - 0.25 Mb
27:Prokaryotic polymerase
2456:Eadie–Hofstee diagram
2389:Allosteric regulation
1890:Reverse transcriptase
1138:Replication protein A
907:Origin of replication
2466:Lineweaver–Burk plot
1679:diphosphotransferase
1661:Thiamine-diphosphate
1368:-containing groups (
1109:Replication factor C
197:that is involved in
2261:: protein-histidine
2179:; protein acceptor)
2067:mRNA capping enzyme
2059:Guanylyltransferase
246:mutagenic potential
2425:Enzyme superfamily
2358:Enzyme promiscuity
1537:Phosphoinositide 3
1381:phosphotransferase
2581:
2580:
2290:
2289:
2286:
2285:
2162:
2161:
2101:
2100:
2002:
2001:
1915:Template-directed
1669:
1668:
1636:Phosphomevalonate
1328:
1327:
1285:
1284:
1121:Flap endonuclease
951:
950:
938:Okazaki fragments
188:DNA polymerase IV
185:
184:
181:
180:
16:(Redirected from
2628:
2598:
2597:
2589:
2461:Hanes–Woolf plot
2404:Enzyme activator
2399:Enzyme inhibitor
2373:Enzyme catalysis
2317:
2310:
2303:
2294:
2278:Histidine kinase
2201:tyrosine kinases
2191:protein-tyrosine
2183:
2113:
1920:RNA polymerase I
1743:
1734:
1587:Aspartate kinase
1582:Phosphoglycerate
1399:
1355:
1348:
1341:
1332:
1078:DNA polymerase I
962:
922:Replication fork
814:Licensing factor
630:
601:
594:
587:
578:
572:
571:
561:
529:
520:
519:
509:
499:
475:
469:
468:
458:
426:
420:
419:
409:
385:
379:
378:
368:
336:
330:
329:
319:
309:
277:
154:
61:
56:Escherichia coli
37:
21:
2636:
2635:
2631:
2630:
2629:
2627:
2626:
2625:
2616:DNA replication
2606:
2605:
2604:
2592:
2584:
2582:
2577:
2489:Oxidoreductases
2475:
2451:Enzyme kinetics
2439:
2435:List of enzymes
2408:
2377:
2348:Catalytic triad
2326:
2321:
2291:
2282:
2253:
2231:
2206:
2177:
2171:
2167:2.7.10-2.7.13:
2158:
2142:
2109:: miscellaneous
2097:
2071:
2053:
2030:
2013:exoribonuclease
2010:
1998:
1984:Polyadenylation
1901:
1727:
1721:
1709:
1691:
1687:
1681:
1665:
1627:
1614:
1591:
1563:
1393:
1387:
1379:
1373:
1359:
1329:
1324:
1281:
1259:
1099:
1095:
1089:
1083:Klenow fragment
966:
947:
931:leading strands
895:
705:
701:
695:
634:
619:
608:DNA replication
605:
575:
544:(14): 2187–96.
531:
530:
523:
490:(13): 8737–41.
477:
476:
472:
428:
427:
423:
387:
386:
382:
351:(22): 6259–65.
338:
337:
333:
300:(25): 13792–7.
279:
278:
274:
270:
252:duplication by
231:
58:
53:
35:
28:
23:
22:
15:
12:
11:
5:
2634:
2632:
2624:
2623:
2618:
2608:
2607:
2603:
2602:
2579:
2578:
2576:
2575:
2562:
2549:
2536:
2523:
2510:
2497:
2483:
2481:
2477:
2476:
2474:
2473:
2468:
2463:
2458:
2453:
2447:
2445:
2441:
2440:
2438:
2437:
2432:
2427:
2422:
2416:
2414:
2413:Classification
2410:
2409:
2407:
2406:
2401:
2396:
2391:
2385:
2383:
2379:
2378:
2376:
2375:
2370:
2365:
2360:
2355:
2350:
2345:
2340:
2334:
2332:
2328:
2327:
2322:
2320:
2319:
2312:
2305:
2297:
2288:
2287:
2284:
2283:
2281:
2280:
2275:
2270:
2264:
2262:
2255:
2254:
2252:
2251:
2242:
2240:
2233:
2232:
2230:
2229:
2220:
2218:
2208:
2207:
2205:
2204:
2195:
2193:
2180:
2175:
2169:protein kinase
2164:
2163:
2160:
2159:
2157:
2156:
2150:
2148:
2144:
2143:
2141:
2140:
2135:
2130:
2125:
2119:
2117:
2110:
2103:
2102:
2099:
2098:
2096:
2095:
2090:
2079:
2077:
2073:
2072:
2070:
2069:
2063:
2061:
2055:
2054:
2052:
2051:
2046:
2040:
2038:
2032:
2031:
2029:
2028:
2023:
2017:
2015:
2008:Phosphorolytic
2004:
2003:
2000:
1999:
1997:
1996:
1991:
1986:
1981:
1976:
1975:
1974:
1969:
1964:
1954:
1953:
1952:
1942:
1937:
1932:
1927:
1922:
1917:
1911:
1909:
1907:RNA polymerase
1903:
1902:
1900:
1899:
1898:
1897:
1887:
1883:
1882:
1881:
1880:
1875:
1870:
1859:
1858:
1857:
1852:
1847:
1842:
1831:
1825:
1824:
1823:
1816:
1811:
1806:
1801:
1790:
1789:
1788:
1781:
1776:
1771:
1766:
1755:
1751:
1749:
1747:DNA polymerase
1740:
1731:
1725:
1711:
1710:
1708:
1707:
1702:
1696:
1694:
1689:
1685:
1671:
1670:
1667:
1666:
1664:
1663:
1658:
1653:
1648:
1643:
1638:
1632:
1630:
1625:
1616:
1615:
1613:
1612:
1606:
1604:
1593:
1592:
1590:
1589:
1584:
1578:
1576:
1565:
1564:
1562:
1561:
1556:
1551:
1550:
1549:
1544:
1534:
1532:Diacylglycerol
1529:
1524:
1519:
1514:
1509:
1504:
1499:
1494:
1493:
1492:
1482:
1477:
1472:
1471:
1470:
1465:
1460:
1455:
1450:
1443:Phosphofructo-
1440:
1435:
1434:
1433:
1423:
1418:
1412:
1410:
1396:
1391:
1375:
1374:
1360:
1358:
1357:
1350:
1343:
1335:
1326:
1325:
1323:
1322:
1321:
1320:
1315:
1310:
1295:
1293:
1287:
1286:
1283:
1282:
1280:
1279:
1274:
1267:
1265:
1261:
1260:
1258:
1257:
1251:
1250:
1249:
1248:
1237:
1236:
1235:
1234:
1229:
1224:
1219:
1209:
1208:
1207:
1202:
1197:
1192:
1182:
1181:
1180:
1175:
1170:
1165:
1155:
1148:
1147:
1146:
1145:
1135:
1130:
1129:
1128:
1118:
1117:
1116:
1105:
1103:
1091:
1090:
1088:
1087:
1086:
1085:
1070:
1069:
1068:
1067:
1057:
1052:
1047:
1042:
1041:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
974:
972:
959:
953:
952:
949:
948:
946:
945:
940:
935:
934:
933:
918:
917:
903:
901:
897:
896:
894:
893:
888:
878:
877:
867:
866:
865:
864:
859:
848:
847:
846:
845:
840:
835:
824:
823:
817:
816:
810:
809:
808:
807:
802:
797:
792:
787:
782:
771:
770:
764:
763:
757:
756:
755:
754:
749:
744:
739:
734:
729:
718:
717:
711:
709:
704:preparation in
697:
696:
694:
693:
692:
691:
680:
679:
678:
677:
672:
667:
656:
655:
649:
648:
642:
640:
627:
621:
620:
606:
604:
603:
596:
589:
581:
574:
573:
521:
470:
421:
380:
331:
271:
269:
266:
230:
224:
183:
182:
179:
178:
173:
169:
168:
163:
159:
158:
150:
149:
142:
136:
135:
130:
124:
123:
119:
118:
113:
107:
106:
101:
95:
94:
89:
83:
82:
77:
73:
72:
67:
63:
62:
51:
47:
46:
42:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2633:
2622:
2619:
2617:
2614:
2613:
2611:
2601:
2596:
2591:
2587:
2573:
2569:
2568:
2563:
2560:
2556:
2555:
2550:
2547:
2543:
2542:
2537:
2534:
2530:
2529:
2524:
2521:
2517:
2516:
2511:
2508:
2504:
2503:
2498:
2495:
2491:
2490:
2485:
2484:
2482:
2478:
2472:
2469:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2448:
2446:
2442:
2436:
2433:
2431:
2430:Enzyme family
2428:
2426:
2423:
2421:
2418:
2417:
2415:
2411:
2405:
2402:
2400:
2397:
2395:
2394:Cooperativity
2392:
2390:
2387:
2386:
2384:
2380:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2353:Oxyanion hole
2351:
2349:
2346:
2344:
2341:
2339:
2336:
2335:
2333:
2329:
2325:
2318:
2313:
2311:
2306:
2304:
2299:
2298:
2295:
2279:
2276:
2274:
2271:
2269:
2266:
2265:
2263:
2260:
2256:
2250:
2249:
2244:
2243:
2241:
2238:
2234:
2228:
2227:
2222:
2221:
2219:
2217:
2213:
2209:
2203:
2202:
2197:
2196:
2194:
2192:
2188:
2184:
2181:
2178:
2170:
2165:
2155:
2152:
2151:
2149:
2145:
2139:
2136:
2134:
2131:
2129:
2126:
2124:
2121:
2120:
2118:
2114:
2111:
2108:
2104:
2094:
2091:
2088:
2084:
2081:
2080:
2078:
2074:
2068:
2065:
2064:
2062:
2060:
2056:
2050:
2047:
2045:
2042:
2041:
2039:
2037:
2033:
2027:
2024:
2022:
2019:
2018:
2016:
2014:
2009:
2005:
1995:
1992:
1990:
1987:
1985:
1982:
1980:
1977:
1973:
1970:
1968:
1965:
1963:
1960:
1959:
1958:
1955:
1951:
1948:
1947:
1946:
1943:
1941:
1938:
1936:
1933:
1931:
1928:
1926:
1923:
1921:
1918:
1916:
1913:
1912:
1910:
1908:
1904:
1896:
1893:
1892:
1891:
1888:
1885:
1884:
1879:
1876:
1874:
1871:
1869:
1866:
1865:
1863:
1860:
1856:
1853:
1851:
1848:
1846:
1843:
1841:
1838:
1837:
1835:
1832:
1829:
1826:
1822:
1821:
1817:
1815:
1812:
1810:
1807:
1805:
1802:
1800:
1797:
1796:
1794:
1791:
1787:
1786:
1782:
1780:
1777:
1775:
1772:
1770:
1767:
1765:
1762:
1761:
1759:
1756:
1753:
1752:
1750:
1748:
1744:
1741:
1739:
1735:
1732:
1729:
1720:
1716:
1712:
1706:
1703:
1701:
1698:
1697:
1695:
1692:
1680:
1676:
1672:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1633:
1631:
1628:
1621:
1617:
1611:
1608:
1607:
1605:
1602:
1598:
1594:
1588:
1585:
1583:
1580:
1579:
1577:
1574:
1570:
1566:
1560:
1557:
1555:
1552:
1548:
1547:Class II PI 3
1545:
1543:
1540:
1539:
1538:
1535:
1533:
1530:
1528:
1525:
1523:
1522:Deoxycytidine
1520:
1518:
1515:
1513:
1510:
1508:
1505:
1503:
1500:
1498:
1495:
1491:
1490:ADP-thymidine
1488:
1487:
1486:
1483:
1481:
1478:
1476:
1473:
1469:
1466:
1464:
1461:
1459:
1456:
1454:
1451:
1449:
1446:
1445:
1444:
1441:
1439:
1436:
1432:
1429:
1428:
1427:
1424:
1422:
1419:
1417:
1414:
1413:
1411:
1408:
1404:
1400:
1397:
1394:
1386:
1382:
1376:
1371:
1367:
1363:
1356:
1351:
1349:
1344:
1342:
1337:
1336:
1333:
1319:
1316:
1314:
1311:
1309:
1306:
1305:
1304:
1300:
1297:
1296:
1294:
1292:
1288:
1278:
1275:
1273:
1269:
1268:
1266:
1262:
1256:
1253:
1252:
1247:
1244:
1243:
1242:
1239:
1238:
1233:
1230:
1228:
1225:
1223:
1220:
1218:
1215:
1214:
1213:
1210:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1187:
1186:
1183:
1179:
1176:
1174:
1171:
1169:
1166:
1164:
1161:
1160:
1159:
1156:
1153:
1150:
1149:
1144:
1141:
1140:
1139:
1136:
1134:
1133:Topoisomerase
1131:
1127:
1124:
1123:
1122:
1119:
1115:
1112:
1111:
1110:
1107:
1106:
1104:
1101:
1092:
1084:
1081:
1080:
1079:
1075:
1072:
1071:
1066:
1063:
1062:
1061:
1060:Topoisomerase
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
984:
981:
980:
979:
976:
975:
973:
970:
963:
960:
958:
954:
944:
941:
939:
936:
932:
928:
925:
924:
923:
920:
919:
916:
912:
908:
905:
904:
902:
898:
892:
889:
887:
883:
880:
879:
876:
872:
869:
868:
863:
860:
858:
855:
854:
853:
850:
849:
844:
841:
839:
836:
834:
831:
830:
829:
826:
825:
822:
819:
818:
815:
812:
811:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
777:
776:
773:
772:
769:
766:
765:
762:
759:
758:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
724:
723:
720:
719:
716:
713:
712:
710:
707:
698:
690:
687:
686:
685:
682:
681:
676:
673:
671:
668:
666:
663:
662:
661:
658:
657:
654:
651:
650:
647:
644:
643:
641:
638:
631:
628:
626:
622:
617:
613:
609:
602:
597:
595:
590:
588:
583:
582:
579:
569:
565:
560:
555:
551:
547:
543:
539:
535:
528:
526:
522:
517:
513:
508:
503:
498:
493:
489:
485:
481:
474:
471:
466:
462:
457:
452:
448:
444:
440:
436:
432:
425:
422:
417:
413:
408:
403:
399:
395:
391:
384:
381:
376:
372:
367:
362:
358:
354:
350:
346:
342:
335:
332:
327:
323:
318:
313:
308:
303:
299:
295:
291:
289:
285:
276:
273:
267:
265:
263:
259:
255:
251:
247:
243:
239:
235:
229:
225:
223:
221:
216:
212:
208:
204:
200:
196:
193:
189:
177:
174:
170:
167:
164:
160:
155:
151:
148:
147:
143:
141:
137:
134:
131:
129:
125:
120:
117:
114:
112:
108:
105:
102:
100:
99:RefSeq (Prot)
96:
93:
90:
88:
84:
81:
78:
74:
71:
68:
64:
60:
57:
52:
48:
43:
38:
33:
19:
2567:Translocases
2564:
2551:
2538:
2525:
2512:
2502:Transferases
2499:
2486:
2343:Binding site
2245:
2223:
2198:
1833:
1819:
1784:
1542:Class I PI 3
1507:Pantothenate
1378:2.7.1-2.7.4:
1362:Transferases
1272:Processivity
1098:synthesis in
541:
538:Biochemistry
537:
487:
483:
473:
438:
434:
424:
400:(3): 571–9.
397:
393:
383:
348:
344:
334:
297:
293:
287:
283:
275:
258:transversion
242:8-oxoguanine
232:
228:8-oxoguanine
219:
214:
210:
202:
187:
186:
144:
79:
76:Alt. symbols
69:
55:
2338:Active site
2093:Transposase
2083:Recombinase
1728:-nucleoside
1554:Sphingosine
1291:Termination
965:Prokaryotic
957:Replication
633:Prokaryotic
612:prokaryotic
610:(comparing
441:(1): 45–9.
207:exonuclease
199:mutagenesis
192:prokaryotic
166:Swiss-model
104:NP_414766.1
45:Identifiers
2610:Categories
2541:Isomerases
2515:Hydrolases
2382:Regulation
1895:Telomerase
1738:Polymerase
1512:Mevalonate
1475:Riboflavin
1366:phosphorus
1303:Telomerase
1277:DNA ligase
1270:Movement:
1094:Eukaryotic
1065:DNA gyrase
1050:DNA ligase
969:elongation
700:Eukaryotic
637:initiation
625:Initiation
616:eukaryotic
268:References
250:chromosome
238:damage DNA
195:polymerase
162:Structures
157:Search for
140:Chromosome
122:Other data
40:DNA pol IV
2420:EC number
2087:Integrase
2011:3' to 5'
1656:Guanylate
1651:Uridylate
1641:Adenylate
1485:Thymidine
1480:Shikimate
1241:DNA clamp
1055:DNA clamp
1045:Replisome
394:Mol. Cell
128:EC number
2621:EC 2.7.7
2444:Kinetics
2368:Cofactor
2331:Activity
2021:RNase PH
1629:acceptor
1610:Creatine
1603:acceptor
1575:acceptor
1517:Pyruvate
1502:Glycerol
1463:Platelet
1438:Galacto-
1409:acceptor
1299:Telomere
915:Replicon
871:Helicase
862:RNASEH2A
706:G1 phase
660:Helicase
568:27002236
516:12060704
465:11751576
435:EMBO Rep
416:11463382
375:11080171
176:InterPro
50:Organism
2600:Biology
2554:Ligases
2324:Enzymes
1972:PrimPol
1957:Primase
1431:Hepatic
1426:Fructo-
1212:epsilon
1100:S phase
927:Lagging
882:Primase
857:RNASEH1
852:RNase H
684:Primase
559:5026495
456:1083926
326:9391106
248:. Upon
211:E. coli
172:Domains
133:2.7.7.7
111:UniProt
2586:Portal
2528:Lyases
2259:2.7.13
2237:2.7.12
2212:2.7.11
2187:2.7.10
2026:PNPase
1994:PNPase
1950:POLRMT
1945:ssRNAP
1458:Muscle
1421:Gluco-
1385:kinase
943:Primer
566:
556:
514:
507:124368
504:
463:
453:
414:
373:
366:305832
363:
345:EMBO J
324:
314:
116:Q47155
92:944922
87:Entrez
66:Symbol
18:Pol IV
2480:Types
2107:2.7.8
2076:Other
1715:2.7.7
1675:2.7.6
1620:2.7.4
1597:2.7.3
1569:2.7.2
1453:Liver
1416:Hexo-
1403:2.7.1
1232:POLE4
1227:POLE3
1222:POLE2
1205:POLD4
1200:POLD3
1195:POLD2
1190:POLD1
1185:delta
1178:PRIM2
1173:PRIM1
1168:POLA2
1163:POLA1
1158:alpha
891:PRIM2
886:PRIM1
843:SSBP4
838:SSBP3
833:SSBP2
317:28386
190:is a
2572:list
2565:EC7
2559:list
2552:EC6
2546:list
2539:EC5
2533:list
2526:EC4
2520:list
2513:EC3
2507:list
2500:EC2
2494:list
2487:EC1
2246:see
2224:see
2199:see
1573:COOH
1372:2.7)
1318:DKC1
1313:TERC
1308:TERT
1264:Both
1246:PCNA
1217:POLE
1143:RPA1
1126:FEN1
1114:RFC1
1038:holE
1033:holD
1028:holC
1023:holB
1018:holA
1013:dnaX
1008:dnaT
1003:dnaQ
998:dnaN
993:dnaH
988:dnaE
983:dnaC
929:and
900:Both
875:HFM1
805:MCM7
800:MCM6
795:MCM5
790:MCM4
785:MCM3
780:MCM2
768:Cdt1
761:Cdc6
752:ORC6
747:ORC5
742:ORC4
737:ORC3
732:ORC2
727:ORC1
689:dnaG
670:dnaB
665:dnaA
653:dnaC
564:PMID
512:PMID
461:PMID
412:PMID
371:PMID
322:PMID
288:dinP
284:dinB
220:dinB
215:dinB
203:dinB
80:dinP
70:dinB
1989:PAP
1930:III
1864:/Y
1855:TDT
1836:/X
1828:III
1820:Pfu
1795:/B
1785:Taq
1760:/A
1527:PFP
1497:NAD
911:Ori
614:to
554:PMC
546:doi
502:PMC
492:doi
451:PMC
443:doi
402:doi
361:PMC
353:doi
312:PMC
302:doi
262:CTP
2612::
2214::
2189::
2174:PO
1935:IV
1925:II
1834:IV
1830:/C
1793:II
1779:T7
1724:PO
1717::
1677::
1624:PO
1622::
1599::
1571::
1407:OH
1405::
1390:PO
1370:EC
1364::
1301::
1076::
884::
873::
675:T7
562:.
552:.
542:55
540:.
536:.
524:^
510:.
500:.
488:99
486:.
482:.
459:.
449:.
437:.
433:.
410:.
396:.
392:.
369:.
359:.
349:19
347:.
343:.
320:.
310:.
298:94
296:.
292:.
2588::
2574:)
2570:(
2561:)
2557:(
2548:)
2544:(
2535:)
2531:(
2522:)
2518:(
2509:)
2505:(
2496:)
2492:(
2316:e
2309:t
2302:v
2176:4
2172:(
2089:)
2085:(
1967:2
1962:1
1940:V
1878:Îş
1873:Îą
1868:η
1862:V
1850:ÎĽ
1845:λ
1840:β
1814:ζ
1809:ε
1804:δ
1799:α
1774:ν
1769:θ
1764:Îł
1758:I
1730:)
1726:4
1722:(
1693:)
1690:7
1688:O
1686:2
1684:P
1682:(
1626:4
1601:N
1468:2
1448:1
1395:)
1392:4
1388:(
1383:/
1354:e
1347:t
1340:v
1154::
1102:)
1096:(
971:)
967:(
913:/
909:/
708:)
702:(
639:)
635:(
618:)
600:e
593:t
586:v
570:.
548::
518:.
494::
467:.
445::
439:3
418:.
404::
398:7
377:.
355::
328:.
304::
286:/
34:.
20:)
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