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Polyethylene glycol

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1902: 754: 266: 201: 75: 66: 1652: 1644: 737: 722:. Proprietary lipid technology is used for each. In both vaccines, the bubbles are coated with a stabilizing molecule of polyethylene glycol. PEG could trigger allergic reaction, and allergic reactions are the driver for both the United Kingdom and Canadian regulators to issue an advisory, noting that: two "individuals in the U.K. ... were treated and have recovered" from 1553: 386: 1578:
when used in biomedical applications. However, as reported by Murali et al., PEG is very sensitive to sonolytic degradation and PEG degradation products can be toxic to mammalian cells. It is, thus, imperative to assess potential PEG degradation to ensure that the final material does not contain
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used for the polymerization process – the most common initiator is a monofunctional methyl ether PEG, or methoxypoly(ethylene glycol), abbreviated mPEG. Lower-molecular-weight PEGs are also available as purer oligomers, referred to as monodisperse, uniform, or discrete. Very high-purity PEG has
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reaction, hypersensitive reactions to PEG are an increasing health concern. Allergy to PEG is usually discovered after a person has been diagnosed with an allergy to several seemingly unrelated products—including processed foods, cosmetics, drugs, and other substances—that contain or were
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PEG is used as a polymer host for solid polymer electrolytes. Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving PEG, with the aim of improving their properties, and in permitting their use in batteries,
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vectors (such as viruses) can be PEG-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect. The size of the PEG polymer has been shown to be important, with larger polymers achieving the best immune
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air. The paint would subsequently flake off in about four minutes. The German Bavarian State Conservation Office developed a PEG preservative that when immediately applied to unearthed artifacts has aided in preserving the colors painted on the pieces of clay
1723:. Polymerization of ethylene oxide is an exothermic process. Overheating or contaminating ethylene oxide with catalysts such as alkalis or metal oxides can lead to runaway polymerization, which can end in an explosion after a few hours. 2709:
Monteiro-Riviere NA, Inman AO, Jackson H, Dunn B, Dimond S (May 2001). "Efficacy of topical phenol decontamination strategies on severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin".
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Firouzabadi H, Iranpoor N, Gholinejad M (January 2010). "One-Pot Thioetherification of Aryl Halides Using Thiourea and Alkyl Bromides Catalyzed by Copper(I) Iodide Free from Foul-Smelling Thiols in Wet Polyethylene Glycol (PEG 200)".
1675:, or ethylene glycol oligomers. The reaction is catalyzed by acidic or basic catalysts. Ethylene glycol and its oligomers are preferable as a starting material instead of water, because they allow the creation of polymers with a low 1594:
for food and pharmaceutical use. They vary in consistency from liquid to solid, depending on the molecular weight, as indicated by a number following the name. They are used commercially in numerous applications, including foods, in
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Ma Y, Ji Y, Zhong T, Wan W, Yang Q, Li A, et al. (December 2017). "Bioprinting-Based PDLSC-ECM Screening for in Vivo Repair of Alveolar Bone Defect Using Cell-Laden, Injectable and Photocrosslinkable Hydrogels".
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Breton MF, Discala F, Bacri L, Foster D, Pelta J, Oukhaled A (3 July 2013). "Exploration of Neutral Versus Polyelectrolyte Behavior of Poly(ethylene glycol)s in Alkali Ion Solutions using Single-Nanopore Recording".
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in Stockholm, and similar cases. It replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries. In addition, PEG is used when working with
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shock. The US CDC stated that in their jurisdiction six cases of "severe allergic reaction" had been recorded from more than 250,000 vaccinations, and of those six only one person had a "history of vaccination
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in the gel that promote healing in the gums. The gel with encapsulated stem cells was to be injected into the site of disease and crosslinked to create the microenvironment required for the stem cells to
642:) is the generic name for polyethylene glycol used as a laxative. The name may be followed by a number which represents the average molecular weight (e.g. macrogol 3350, macrogol 4000 or macrogol 6000). 1004:, polyethylene glycols are the molecules of choice for the functioning ion channels diameter studies, because in aqueous solutions they have a spherical shape and can block ion channel conductance. 1292:
samples collected from 1990 to 1999. According to the study's authors, this result suggests that anti-PEG antibodies may be present, typically at low levels, in people who were never treated with
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of Scientific Polymer Products, Inc., poly(ethylene glycol) molecular weights run up to about 20,000, while those of poly(ethylene oxide) have six or seven digits.
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Ueno K, Nakamura S, Shimotani H, Ohtomo A, Kimura N, Nojima T, et al. (November 2008). "Electric-field-induced superconductivity in an insulator".
1392:. Since purification and separation of pure oligomers is difficult, the price for this type of quality is often 10–1000 fold that of polydisperse PEG. 2237: 3055: 2461:"Ion Complexation Explains Orders of Magnitude Changes in the Equilibrium Constant of Biochemical Reactions in Buffers Crowded by Nonionic Compounds" 2167: 3251:
Yang, Qi; Jacobs, Timothy M.; McCallen, Justin D.; Moore, Dominic T.; Huckaby, Justin T.; Edelstein, Jasmine N.; Lai, Samuel K. (16 November 2016).
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Winger M, De Vries AH, Van Gunsteren WF (2009). "Force-field dependence of the conformational properties of α,ω-dimethoxypolyethylene glycol".
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Rameez S, Alosta H, Palmer AF (May 2008). "Biocompatible and biodegradable polymersome encapsulated hemoglobin: a potential oxygen carrier".
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of human body weight when ingested by mouth. Because of its low toxicity, PEO is used in a variety of edible products. It is also used as a
2033: 1383:) due to chain length effects, their chemical properties are nearly identical. Different forms of PEG are also available, depending on the 1132: 3683: 2636:"Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study" 1886: 1379:. While PEG and PEO with different molecular weights find use in different applications, and have different physical properties (e.g. 956: 3593: 3041: 2190: 2031:
Seregin SS, Amalfitano A (2009). "Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectors".
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drugs. Due to its ubiquity in many products and the large percentage of the population with antibodies to PEG, which indicates an
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assays to mimic highly crowded cellular conditions. Although polyethylene glycol is considered biologically inert, it can form
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and other organic artifacts that have been salvaged from underwater archaeological contexts, as was the case with the warship
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is more prevalent in the field of polymer chemistry. Because different applications require different polymer chain lengths,
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PEG has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator.
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independently isolated products that were polyethylene glycols. Polyethylene glycol is produced by the interaction of
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An example study was done using PEG-diacrylate hydrogels to recreate vascular environments with the encapsulation of
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The numbers that are often included in the names of PEGs indicate their average molecular weights (e.g. a PEG with
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can be cationic or anionic. The anionic mechanism is preferable because it allows one to obtain PEG with a low
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process. The reaction is catalyzed by magnesium-, aluminium-, or calcium-organoelement compounds. To prevent
873:. This model furthered vascular disease modeling and isolated macrophage phenotype's effect on blood vessels. 4165: 3676: 2763:"A simple method for the determination of the pore radius of ion channels in planar lipid bilayer membranes" 1557: 927: 815: 2245: 196: 3988: 3847: 3661: 3368:"Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized" 3061: 2935: 615: 162: 4135: 3814: 1664: 1389: 908: 87: 1973: 3085:"Macrotribological Studies of Poly(L-lysine)-graft-Poly(ethylene glycol) in Aqueous Glycerol Mixtures" 1939: 4175: 3489: 3084: 2999: 2815: 2719: 2214: 1583: 1456: 918:
PEG is used to fuse two different types of cells, most often B-cells and myelomas in order to create
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experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.
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section) in a therapeutic has been theorized by Ma et al. They propose using the hydrogel to address
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unearthed at a UNESCO World Heritage site in China. These painted artifacts were created during the
4155: 4145: 3998: 3935: 3895: 3885: 2966: 2153:"Pfizer-BioNTech COVID-19 vaccine: Health Canada recommendations for people with serious allergies" 1783: 1754: 1491: 1097: 669: 261: 124: 4150: 4025: 3905: 3776: 3728: 3669: 3535:"Rapid detection of polyethylene glycol sonolysis upon functionalization of carbon nanomaterials" 3515: 3348: 3272: 3184: 3117: 2743: 2616: 2392: 2107: 2058: 1208: 1129: 1025: 845: 841: 763: 654: 1679:(narrow molecular weight distribution). Polymer chain length depends on the ratio of reactants. 3656: 2412:"DNA binding proteins explore multiple local configurations during docking via rapid rebinding" 4160: 4140: 4013: 3910: 3890: 3746: 3589: 3564: 3462: 3397: 3340: 3298: 3280: 3233: 3037: 3015: 2970: 2915: 2843: 2784: 2735: 2689: 2665: 2608: 2567: 2526: 2490: 2441: 2305: 2186: 2099: 2050: 2013: 1882: 1481: 1384: 1176: 1125: 923: 912: 808: 35: 3583: 1490:
is the act of covalently coupling a PEG structure to another larger molecule, for example, a
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Krasilnikov OV, Sabirov RZ, Ternovsky VI, Merzliak PG, Muratkhodjaev JN (September 1992).
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A 2015 study appears to challenge the FDA's conclusion. In the study, a high-sensitivity
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recently been shown to be crystalline, allowing determination of a crystal structure by
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From Polaris to Trident : the development of US fleet ballistic missile technology
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Geisbert TW, Lee AC, Robbins M, Geisbert JB, Honko AN, Sood V, et al. (May 2010).
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Polyethylene oxide, or high-molecular-weight polyethylene glycol, is synthesized by
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PEG is injected into industrial processes to reduce foaming in separation equipment.
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Stone CA, Liu Y, Relling MV, Krantz MS, Pratt AL, Abreo A, et al. (May 2019).
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undocumented contaminants that can introduce artifacts into experimental results.
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has tended to refer to oligomers and polymers with a molecular mass below 20,000
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Kollisolv, Carbowax, GoLYTELY, GlycoLax, Fortrans, TriLyte, Colyte, Halflytely,
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in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
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and are commercially available over a wide range of molecular weights from 300
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originated this technique, which they used for antibody production, winning a
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Oregon State University informational paper on using PEG as a wood stabilizer
3550: 3284: 3276: 2530: 2168:"EU regulator gives conditional approval to Pfizer-BioNTech COVID-19 vaccine" 1878: 4109: 4104: 4061: 4041: 4036: 3968: 3880: 3875: 3819: 3741: 3736: 3697: 3320: 1831: 1814: 1632: 1628: 1624: 1612: 1596: 1380: 1293: 1219: 893: 852: 745: 673: 600: 536: 532: 3568: 3466: 3458: 3401: 3344: 3302: 3237: 3019: 2847: 2802:
Bárcena-Uribarri I, Thein M, Maier E, Bonde M, Bergström S, Benz R (2013).
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can help prevent adverse reactions due to pre-existing adenovirus immunity.
3204:"Anti-PEG immunity: emergence, characteristics, and unaddressed questions" 2788: 2603: 2586: 2562: 2545: 2459:
Bielec K, Kowalski A, Bubak G, Witkowska Nery E, Hołyst R (January 2022).
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Polyethylene glycol is also commonly used as a polar stationary phase for
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PEO's have "very low singledose oral toxicity", on the order of tens of
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The production of polyethylene glycol was first reported in 1859. Both
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PEGs have multiple PEG chains normally grafted onto a polymer backbone.
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Murali VS, Wang R, Mikoryak CA, Pantano P, Draper R (September 2015).
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PEGs have three to ten PEG chains emanating from a central core group.
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of protein crystals can reveal the atomic structure of the proteins.
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Except where otherwise noted, data are given for materials in their
3321:"Immediate-type hypersensitivity to polyethylene glycols: a review" 3208:
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
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Ganji M, Docter M, Le Grice SF, Abbondanzieri EA (September 2016).
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PEGs have 10 to 100 PEG chains emanating from a central core group.
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can be used on phenol skin burns to deactivate any residual phenol.
3960: 3824: 2371:"Macrophages Influence Vessel Formation in 3D Bioactive Hydrogels" 1650: 1642: 1551: 1514: 1375:
PEG and PEO are liquids or low-melting solids, depending on their
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electro-chromic display systems, and other products in the future.
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PEG and related polymers (PEG phospholipid constructs) are often
3137:"Potential Contaminants - 1,4-Dioxane A Manufacturing Byproduct" 1769:) are used to prepare low-molecular-weight polyethylene glycol. 1232: 1143: 1078: 646: 3665: 2238:"Conservators preserve the paint layers of the Terracotta Army" 1970:"Polyethyleneglycol (PEG 4000 ) | Laxolite | Medical Dialogues" 3983: 3057:
Indirect Food Additives and Polymers: Migration and Toxicology
1545:. It is coupled to hydrophobic molecules to produce non-ionic 1328:. The three names are chemically synonymous, but historically 1277:(FDA or US FDA) regards PEG as biologically inert and safe. 1103:
PEG is used as an anti-foaming agent in food and drinks – its
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of polymer chains from solution, chelating additives such as
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PEG is the main ingredient in the paint (known as "fill") in
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would have an average molecular weight of approximately 400
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PEG is used to extend the size and durability of very large
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The Journal of Allergy and Clinical Immunology. In Practice
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PEG is often used (as an internal calibration compound) in
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PEG was used as an additive to silver halide photographic
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PEGs and methoxypolyethylene glycols are manufactured by
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to a polymer of any molecular mass. PEGs are prepared by
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with many applications, from industrial manufacturing to
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Lauryl methyl gluceth-10 hydroxypropyl dimonium chloride
718:, or mRNA, encased in a bubble of oily molecules called 3433: 3431: 2267:
Larmer B (June 2012). "Terra-Cotta Warriors in Color".
2207:"Anti-Freeze is Not a Green Wood Stabilizer – Buzz Saw" 1730:. It is necessary to hold the growing polymer chain in 749:
undergoing conservation treatment with PEG in the 1980s
563:. The structure of PEG is commonly expressed as H−(O−CH 394: 3083:
Nalam PC, Clasohm JN, Mashaghi A, Spencer ND (2009).
1039:. In this application, it binds water and helps keep 757:
Terra cotta warrior, showing traces of original color
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as an ink solvent and lubricant for the print heads.
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PEG has been used to preserve the painted colors on
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Engineered Materials Handbook: Ceramics and Glasses
2936:"Current EU approved additives and their E Numbers" 1395:PEGs are also available with different geometries. 496: 469: 446: 1903:"Polyethylene Glycol as Pharmaceutical Excipient" 1715:Depending on the catalyst type, the mechanism of 1138:Dimethyl ethers of PEG are the key ingredient of 370:182–287 °C; 360–549 °F; 455–560 K 2686:Modern Blood Banking & Transfusion Practices 2244:. Technische Universität München. Archived from 1655:Polyethylene glycol 4000, pharmaceutical quality 1043:uniformly distributed throughout the toothpaste. 2910:. Archived from the original on 7 January 2012. 1933: 1931: 1929: 1927: 1925: 1923: 1647:Polyethylene glycol 400, pharmaceutical quality 645:The possibility that PEG could be used to fuse 133: 3135:Center for Food Safety and Applied Nutrition. 1870:Ullmann's Encyclopedia of Industrial Chemistry 1348:to polymers with a molecular mass above 20,000 1332:is preferred in the biomedical field, whereas 1254:, which is hazardous. Ethylene glycol and its 825:PEG has been used as the hydrophilic block of 3677: 2076:Cabanillas B, Akdis CA, Novak N (June 2021). 1794:Polyethylene glycol propylene glycol cocoates 840:PEG is a component of the propellent used in 49:For medical uses of polyethylene glycol, see 8: 2965:. Cambridge: Cambridge Univ. Press. p.  2587:"RNAi therapeutics: SNALPing siRNAs in vivo" 1506:are commonly used injectable treatments for 876:PEG is commonly used as a crowding agent in 3684: 3670: 3662: 1998:ACS Biomaterials Science & Engineering 788:as a stabilizer, and to prevent shrinkage. 698:lipid is used as an excipient in both the 649:is being explored by researchers studying 264: 199: 57: 3558: 3509: 3438:French AC, Thompson AL, Davis BG (2009). 3391: 3292: 3227: 3178: 3111: 3060:. CRC. pp. 1114–1116. Archived from 2837: 2827: 2778: 2659: 2602: 2561: 2511:The Journal of Physical Chemistry Letters 2484: 2465:The Journal of Physical Chemistry Letters 2435: 2386: 2166:Furtula A, Jordans F (21 December 2020). 2093: 1862: 1860: 1830: 231: 2369:Moore EM, Ying G, West JL (March 2017). 1603:, as dispersing agents, as solvents, in 851:PEG has been used as a solvent for aryl 2938:. UK Government – Food Standards Agency 1805: 599:Pharmaceutical-grade PEG is used as an 260: 3896:Magnesium hydroxide (milk of magnesia) 2913: 2544:Kreppel F, Kochanek S (January 2008). 1148:integrated gasification combined cycle 1046:PEG is under investigation for use in 190: 3314: 3312: 2874:US Government – Food and Drug Agency 1069:for applications such as elastomeric 932:Nobel Prize in Physiology or Medicine 622:is used for bowel preparation before 161: 7: 3588:. New York: Dekker. pp. 27–28. 2133:from the original on 9 December 2020 2034:Expert Opinion on Biological Therapy 1813:Kahovec J, Fox RB, Hatada K (2002). 1455:), the ratio of which is called the 1133:submarine-launched ballistic missile 665: 350: 3167:International Journal of Toxicology 957:stable nucleic acid lipid particles 630:or for children with constipation. 618:with polyethylene glycol and added 3585:Alkylene oxides and their polymers 3319:Wenande E, Garvey LH (July 2016). 2344:Advanced Synthesis & Catalysis 2170:. The Globe and Mail Inc. Reuters. 2155:. Health Canada. 12 December 2020. 1124:-plasticized polyethylene glycol ( 1061:Polymer segments derived from PEG 634:(with brand names such as Laxido, 25: 3539:Experimental Biology and Medicine 3325:Clinical and Experimental Allergy 2324:"Facts: Polaris Poseidon Trident" 1494:, which is then referred to as a 2712:Toxicology and Industrial Health 2181:Kvarning LÅ, Ohrelius B (1998). 1570:) nanometric crystallites (4 nm) 1305:Available forms and nomenclature 1243:coating for various surfaces in 1179:in the preparation of technical 740:The remains of the 16th century 606:PEG is the basis of a number of 427: 384: 73: 64: 2010:10.1021/acsbiomaterials.7b00601 1446:number average molecular weight 1435:weight average molecular weight 672:(gum disease) by encapsulating 380:(at 25 °C , 100 kPa). 3582:Bailey FE, Koleske JV (1990). 2185:. Atlantis. pp. 133–141. 1270:) if applied to damaged skin. 1247:and non-aqueous applications. 1150:(IGCC) power plants to remove 907:for plasmid DNA isolation and 1: 3036:, Vol. 4. ASM International. 2864:. BBC News. 1 September 2002. 2652:10.1016/S0140-6736(10)60357-1 2125:Bostock N (9 December 2020). 1873:. Weinheim: Wiley-VCH. 2000. 1207:PEG is an ingredient in some 3269:10.1021/acs.analchem.6b03437 3032:Schneider, Samuel J. (1991) 2882:Food and Drug Administration 2862:"Tattoo to monitor diabetes" 2829:10.1371/journal.pone.0078272 2780:10.1016/0378-1097(92)90079-4 2767:FEMS Microbiology Immunology 2236:Reiffert S (18 March 2015). 2213:. 2 May 2006. Archived from 1500:PEGylated interferon alfa-2a 1275:Food and Drug Administration 842:UGM-133M Trident II Missiles 2877:"Food Additive Status List" 2477:10.1021/acs.jpclett.1c03596 1749:Alkaline catalysts such as 1619:. Some specific groups are 1211:. (Not to be confused with 1107:is 1521 or E1521 in the EU. 1031:PEG is used in a number of 993:in a laboratory situation, 4192: 3994:Sodium lauryl sulfoacetate 3384:10.1016/j.jaip.2018.12.003 3180:10.1177/109158189901800208 2328:Strategic Systems Programs 1819:Pure and Applied Chemistry 903:PEG is commonly used as a 884:complexes with monovalent 773:PEG is frequently used to 587: 48: 29: 3502:10.1080/00268970902794826 3104:10.1007/s11249-009-9549-9 2920:: CS1 maint: unfit URL ( 2732:10.1191/0748233701th095oa 2183:The Vasa – The Royal Ship 2047:10.1517/14712590903307388 1728:suspension polymerization 1556:Polyethylene oxide (PEO, 1250:The precursor to PEGs is 1014:PEG is the basis of many 959:(SNALPs) used to package 900:of biochemical reactions. 814:PEG derivatives, such as 775:preserve waterlogged wood 612:MiraLax, RestoraLAX, etc. 374: 359: 333: 276: 117: 105: 86: 81: 72: 63: 3692:Drugs for constipation ( 3551:10.1177/1535370214567615 3421:29 December 2006 at the 3094:(Submitted manuscript). 2674:(free with registration) 1879:10.1002/14356007.a21_579 1590:for industrial use, and 1284:assay detected anti-PEG 978:to enhance detection of 896:, Rb, and Cs, affecting 816:narrow range ethoxylates 704:Pfizer–BioNTech vaccines 30:Not to be confused with 3202:Yang Q, Lai SK (2015). 2688:. F. A. Davis Company. 2585:Rossi JJ (April 2006). 1907:pharmaceutical.basf.com 1847:"Poly(ethylene glycol)" 1832:10.1351/pac200274101921 1599:, in pharmaceutics, in 1429:, and would be labeled 1301:manufactured with PEG. 909:protein crystallization 543:. PEG is also known as 3787:Bulk-forming laxatives 3459:10.1002/anie.200804623 2416:Nucleic Acids Research 2388:10.1002/adbi.201600021 2356:10.1002/adsc.200900671 2290:Bioconjugate Chemistry 1656: 1648: 1571: 1537:, and is insoluble in 1065:impart flexibility to 955:PEG is a component of 844:, in service with the 770:in electronic testers. 758: 750: 616:Whole bowel irrigation 535:compound derived from 217:(additional chemicals) 3815:Polycarbophil calcium 2908:codexalimentarius.net 2684:Harmening DM (2005). 2604:10.1038/sj.gt.3302661 2563:10.1038/sj.mt.6300321 1734:in the course of the 1665:Charles Adolphe Wurtz 1654: 1646: 1586:under the trade name 1555: 1390:x-ray crystallography 898:equilibrium constants 756: 739: 97:poly(ethylene oxide) 3989:Sodium laurilsulfate 3414:For example, in the 3257:Analytical Chemistry 3161:Andersen FA (1999). 2904:"Codex Alimentarius" 1867:"Polyoxyalkylenes". 1457:polydispersity index 1227:Human health effects 1142:, a solvent used by 928:Georges J. F. Köhler 833:used to create some 559:), depending on its 59:Polyethylene glycol 40:Polypropylene glycol 3926:Polyethylene glycol 3886:Magnesium carbonate 3840:Lubricant laxatives 3729:Stimulant laxatives 3616:Polyethylene glycol 3494:2009MolPh.107.1313W 3378:(5): 1533–1540.e8. 3263:(23): 11804–11812. 3054:Sheftel VO (2000). 3004:2008NatMa...7..855U 2957:Spinardi G (1994). 2820:2013PLoSO...878272B 2724:2001ToxIH..17...95M 2646:(9729): 1896–1905. 2375:Advanced Biosystems 2270:National Geographic 2248:on 22 December 2015 1784:Lysozyme PEGylation 1755:potassium hydroxide 1492:therapeutic protein 1480:can be measured by 1368:g/mol to 10,000,000 1209:personal lubricants 1088:formulations (e.g. 1026:personal lubricants 974:, PEG is used as a 793:Terracotta Warriors 768:heat transfer fluid 419:Polyethylene glycol 112:, MiraLAX, MoviPrep 60: 4171:E-number additives 4026:Oxycodone/naloxone 4014:Opioid antagonists 3906:Magnesium peroxide 3777:Sodium picosulfate 3113:20.500.11850/17055 2428:10.1093/nar/gkw666 2217:on 17 January 2022 1657: 1649: 1572: 1513:PEG is soluble in 1273:The United States 1195:Entertainment uses 1135:solid rocket fuel. 989:When working with 846:United States Navy 764:gas chromatography 759: 751: 660:An example of PEG 655:spinal cord injury 545:polyethylene oxide 407:Infobox references 91:poly(oxyethylene) 58: 18:Polyethylene oxide 4123: 4122: 3911:Magnesium sulfate 3891:Magnesium citrate 3863:Osmotic laxatives 3633:www.venus-goa.com 3618:, Chemindustry.ru 3488:(13): 1313–1321. 3482:Molecular Physics 3447:Angewandte Chemie 3337:10.1111/cea.12760 3220:10.1002/wnan.1339 3092:Tribology Letters 2976:978-0-521-41357-2 2695:978-0-8036-1248-8 2550:Molecular Therapy 2523:10.1021/jz400938q 2517:(13): 2202–2208. 2422:(17): 8376–8384. 2302:10.1021/bc700465v 2095:10.1111/all.14711 2041:(12): 1521–1531. 2004:(12): 3534–3545. 1976:. 19 January 2021 1974:Medical Dialogues 1853:. 7 January 2020. 1825:(10): 1921–1956. 1611:bases, as tablet 1482:mass spectrometry 1377:molecular weights 1288:in 72% of random 1175:PEG is used as a 1092:), it is used in 1048:liquid body armor 913:X-ray diffraction 809:mass spectrometry 415:Chemical compound 413: 412: 245:CompTox Dashboard 100: 94: 93:{structure-based} 36:Diethylene glycol 27:Chemical compound 16:(Redirected from 4183: 4052:Methylnaltrexone 3999:Sodium phosphate 3936:Sodium phosphate 3772:Senna glycosides 3686: 3679: 3672: 3663: 3644: 3643: 3641: 3639: 3625: 3619: 3613: 3607: 3606: 3604: 3602: 3579: 3573: 3572: 3562: 3530: 3524: 3523: 3513: 3477: 3471: 3470: 3444: 3435: 3426: 3412: 3406: 3405: 3395: 3363: 3357: 3356: 3316: 3307: 3306: 3296: 3248: 3242: 3241: 3231: 3199: 3193: 3192: 3182: 3158: 3152: 3151: 3149: 3147: 3132: 3126: 3125: 3115: 3089: 3080: 3074: 3073: 3071: 3069: 3064:on 9 August 2007 3051: 3045: 3030: 3024: 3023: 3012:10.1038/nmat2298 2992:Nature Materials 2987: 2981: 2980: 2964: 2954: 2948: 2947: 2945: 2943: 2932: 2926: 2925: 2919: 2911: 2900: 2894: 2893: 2891: 2889: 2872: 2866: 2865: 2858: 2852: 2851: 2841: 2831: 2799: 2793: 2792: 2782: 2758: 2752: 2751: 2706: 2700: 2699: 2681: 2675: 2673: 2663: 2631: 2625: 2624: 2606: 2582: 2576: 2575: 2565: 2541: 2535: 2534: 2505: 2499: 2498: 2488: 2456: 2450: 2449: 2439: 2407: 2401: 2400: 2390: 2366: 2360: 2359: 2338: 2332: 2331: 2320: 2314: 2313: 2285: 2279: 2278: 2264: 2258: 2257: 2255: 2253: 2233: 2227: 2226: 2224: 2222: 2211:The Rockler Blog 2203: 2197: 2196: 2178: 2172: 2171: 2163: 2157: 2156: 2149: 2143: 2142: 2140: 2138: 2122: 2116: 2115: 2097: 2088:(6): 1617–1618. 2073: 2067: 2066: 2028: 2022: 2021: 1992: 1986: 1985: 1983: 1981: 1966: 1960: 1959: 1957: 1955: 1935: 1918: 1917: 1915: 1913: 1899: 1893: 1892: 1864: 1855: 1854: 1843: 1837: 1836: 1834: 1810: 1759:sodium carbonate 1751:sodium hydroxide 1744:dimethylglyoxime 1736:polycondensation 1566: 1424: 1371: 1367: 1351: 1343: 1213:propylene glycol 1156:hydrogen sulfide 1086:molecular-weight 651:peripheral nerve 561:molecular weight 530: 529: 526: 525: 522: 519: 516: 511: 510: 507: 504: 501: 498: 493: 492: 489: 486: 483: 480: 477: 474: 471: 467: 466: 463: 460: 457: 454: 451: 448: 445: 442: 439: 436: 433: 397: 391: 388: 387: 354: 316: 284:Chemical formula 269: 268: 253: 251: 235: 211: 203: 192: 165: 137: 98: 92: 77: 68: 61: 44:Propylene glycol 21: 4191: 4190: 4186: 4185: 4184: 4182: 4181: 4180: 4126: 4125: 4124: 4119: 4068: 4008: 3955: 3946:Sodium tartrate 3921:Pentaerythritol 3901:Magnesium oxide 3857: 3848:Liquid paraffin 3834: 3810:Methylcellulose 3781: 3767:Phenolphthalein 3723: 3711:Stool softeners 3705: 3690: 3653: 3648: 3647: 3637: 3635: 3627: 3626: 3622: 3614: 3610: 3600: 3598: 3596: 3581: 3580: 3576: 3532: 3531: 3527: 3479: 3478: 3474: 3442: 3437: 3436: 3429: 3423:Wayback Machine 3413: 3409: 3365: 3364: 3360: 3318: 3317: 3310: 3250: 3249: 3245: 3201: 3200: 3196: 3160: 3159: 3155: 3145: 3143: 3134: 3133: 3129: 3087: 3082: 3081: 3077: 3067: 3065: 3053: 3052: 3048: 3031: 3027: 2989: 2988: 2984: 2977: 2956: 2955: 2951: 2941: 2939: 2934: 2933: 2929: 2912: 2902: 2901: 2897: 2887: 2885: 2875: 2873: 2869: 2860: 2859: 2855: 2801: 2800: 2796: 2773:(1–3): 93–100. 2760: 2759: 2755: 2708: 2707: 2703: 2696: 2683: 2682: 2678: 2633: 2632: 2628: 2584: 2583: 2579: 2543: 2542: 2538: 2507: 2506: 2502: 2458: 2457: 2453: 2409: 2408: 2404: 2368: 2367: 2363: 2340: 2339: 2335: 2322: 2321: 2317: 2287: 2286: 2282: 2266: 2265: 2261: 2251: 2249: 2235: 2234: 2230: 2220: 2218: 2205: 2204: 2200: 2193: 2180: 2179: 2175: 2165: 2164: 2160: 2151: 2150: 2146: 2136: 2134: 2124: 2123: 2119: 2075: 2074: 2070: 2030: 2029: 2025: 1994: 1993: 1989: 1979: 1977: 1968: 1967: 1963: 1953: 1951: 1940:"Chemical Hope" 1938:Kean S (2017). 1937: 1936: 1921: 1911: 1909: 1901: 1900: 1896: 1889: 1866: 1865: 1858: 1845: 1844: 1840: 1812: 1811: 1807: 1802: 1775: 1768: 1764: 1710: 1706: 1702: 1698: 1694: 1690: 1686: 1673:ethylene glycol 1641: 1592:Carbowax Sentry 1564: 1561: 1535:dichloromethane 1479: 1472: 1465: 1454: 1443: 1419: 1369: 1365: 1349: 1341: 1307: 1229: 1197: 1114: 1112:Industrial uses 1094:Hewlett-Packard 1011: 1009:Commercial uses 862: 860:Biological uses 766:, as well as a 734: 666:Biological uses 596: 588:Main articles: 586: 581: 574: 570: 566: 553:polyoxyethylene 513: 495: 468: 430: 426: 416: 409: 404: 403: 402:  ?) 393: 389: 385: 381: 343: 311: 300: 296: 292: 286: 272: 254: 247: 238: 184: 168: 140: 127: 113: 101: 96: 54: 47: 32:Ethylene glycol 28: 23: 22: 15: 12: 11: 5: 4189: 4187: 4179: 4178: 4173: 4168: 4166:Ether solvents 4163: 4158: 4153: 4148: 4143: 4138: 4128: 4127: 4121: 4120: 4118: 4117: 4112: 4107: 4102: 4097: 4092: 4090:Oxyphenisatine 4087: 4082: 4076: 4074: 4070: 4069: 4067: 4066: 4065: 4064: 4059: 4054: 4049: 4044: 4039: 4029: 4018: 4016: 4010: 4009: 4007: 4006: 4001: 3996: 3991: 3986: 3981: 3976: 3971: 3965: 3963: 3957: 3956: 3954: 3953: 3948: 3943: 3941:Sodium sulfate 3938: 3933: 3923: 3918: 3913: 3908: 3903: 3898: 3893: 3888: 3883: 3878: 3873: 3867: 3865: 3859: 3858: 3856: 3855: 3850: 3844: 3842: 3836: 3835: 3833: 3832: 3827: 3822: 3817: 3812: 3807: 3802: 3797: 3791: 3789: 3783: 3782: 3780: 3779: 3774: 3769: 3764: 3762:Oxyphenisatine 3759: 3754: 3749: 3744: 3739: 3733: 3731: 3725: 3724: 3722: 3721: 3715: 3713: 3707: 3706: 3691: 3689: 3688: 3681: 3674: 3666: 3660: 3659: 3652: 3651:External links 3649: 3646: 3645: 3620: 3608: 3594: 3574: 3545:(9): 1147–51. 3525: 3472: 3453:(7): 1248–52. 3427: 3416:online catalog 3407: 3358: 3308: 3243: 3194: 3153: 3127: 3098:(3): 541–552. 3075: 3046: 3025: 2982: 2975: 2949: 2927: 2895: 2867: 2853: 2814:(11): e78272. 2794: 2753: 2701: 2694: 2676: 2626: 2597:(7): 583–584. 2577: 2536: 2500: 2471:(1): 112–117. 2451: 2402: 2381:(3): 1600021. 2361: 2350:(18): 119–24. 2333: 2315: 2296:(5): 1025–32. 2280: 2259: 2228: 2198: 2191: 2173: 2158: 2144: 2117: 2068: 2023: 1987: 1961: 1919: 1894: 1888:978-3527306732 1887: 1856: 1838: 1804: 1803: 1801: 1798: 1797: 1796: 1791: 1786: 1781: 1774: 1771: 1766: 1762: 1721:polydispersity 1717:polymerization 1713: 1712: 1708: 1704: 1700: 1696: 1692: 1688: 1684: 1677:polydispersity 1669:ethylene oxide 1661:A. V. Lourenço 1640: 1637: 1621:lauromacrogols 1559: 1477: 1470: 1463: 1452: 1441: 1416: 1415: 1409: 1403: 1362:ethylene oxide 1358:polymerization 1326:ethylene oxide 1324:or polymer of 1306: 1303: 1252:ethylene oxide 1228: 1225: 1224: 1223: 1216: 1205: 1196: 1193: 1192: 1191: 1184: 1173: 1170: 1166: 1163: 1152:carbon dioxide 1136: 1113: 1110: 1109: 1108: 1101: 1082: 1059: 1044: 1029: 1010: 1007: 1006: 1005: 998: 987: 968: 953: 946: 935: 924:César Milstein 916: 901: 874: 861: 858: 857: 856: 849: 838: 823: 818:, are used as 812: 805: 789: 771: 733: 730: 729: 728: 692: 678: 658: 643: 604: 585: 582: 580: 577: 572: 568: 564: 414: 411: 410: 405: 383: 382: 378:standard state 375: 372: 371: 368: 362: 361: 357: 356: 344: 339: 336: 335: 331: 330: 327: 321: 320: 312:44.05n + 18.02 309: 303: 302: 298: 294: 290: 287: 282: 279: 278: 274: 273: 271: 270: 257: 255: 243: 240: 239: 237: 236: 228: 226: 220: 219: 213: 205: 204: 194: 186: 185: 183: 182: 178: 176: 170: 169: 167: 166: 158: 156: 150: 149: 146: 145:Abbreviations 142: 141: 139: 138: 130: 128: 123: 120: 119: 115: 114: 107: 103: 102: 99:{source-based} 90: 84: 83: 79: 78: 70: 69: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4188: 4177: 4174: 4172: 4169: 4167: 4164: 4162: 4159: 4157: 4154: 4152: 4149: 4147: 4144: 4142: 4139: 4137: 4134: 4133: 4131: 4116: 4113: 4111: 4108: 4106: 4103: 4101: 4098: 4096: 4093: 4091: 4088: 4086: 4083: 4081: 4078: 4077: 4075: 4071: 4063: 4060: 4058: 4055: 4053: 4050: 4048: 4045: 4043: 4040: 4038: 4035: 4034: 4033: 4030: 4027: 4023: 4020: 4019: 4017: 4015: 4011: 4005: 4002: 4000: 3997: 3995: 3992: 3990: 3987: 3985: 3982: 3980: 3977: 3975: 3972: 3970: 3967: 3966: 3964: 3962: 3958: 3952: 3949: 3947: 3944: 3942: 3939: 3937: 3934: 3931: 3927: 3924: 3922: 3919: 3917: 3914: 3912: 3909: 3907: 3904: 3902: 3899: 3897: 3894: 3892: 3889: 3887: 3884: 3882: 3879: 3877: 3874: 3872: 3869: 3868: 3866: 3864: 3860: 3854: 3851: 3849: 3846: 3845: 3843: 3841: 3837: 3831: 3830:Syrup of figs 3828: 3826: 3823: 3821: 3818: 3816: 3813: 3811: 3808: 3806: 3803: 3801: 3798: 3796: 3795:Dietary fiber 3793: 3792: 3790: 3788: 3784: 3778: 3775: 3773: 3770: 3768: 3765: 3763: 3760: 3758: 3755: 3753: 3750: 3748: 3745: 3743: 3740: 3738: 3735: 3734: 3732: 3730: 3726: 3720: 3717: 3716: 3714: 3712: 3708: 3703: 3699: 3695: 3687: 3682: 3680: 3675: 3673: 3668: 3667: 3664: 3658: 3655: 3654: 3650: 3634: 3630: 3624: 3621: 3617: 3612: 3609: 3597: 3595:9780824783846 3591: 3587: 3586: 3578: 3575: 3570: 3566: 3561: 3556: 3552: 3548: 3544: 3540: 3536: 3529: 3526: 3521: 3517: 3512: 3507: 3503: 3499: 3495: 3491: 3487: 3483: 3476: 3473: 3468: 3464: 3460: 3456: 3452: 3448: 3441: 3434: 3432: 3428: 3424: 3420: 3417: 3411: 3408: 3403: 3399: 3394: 3389: 3385: 3381: 3377: 3373: 3369: 3362: 3359: 3354: 3350: 3346: 3342: 3338: 3334: 3331:(7): 907–22. 3330: 3326: 3322: 3315: 3313: 3309: 3304: 3300: 3295: 3290: 3286: 3282: 3278: 3274: 3270: 3266: 3262: 3258: 3254: 3247: 3244: 3239: 3235: 3230: 3225: 3221: 3217: 3214:(5): 655–77. 3213: 3209: 3205: 3198: 3195: 3190: 3186: 3181: 3176: 3172: 3168: 3164: 3157: 3154: 3142: 3138: 3131: 3128: 3123: 3119: 3114: 3109: 3105: 3101: 3097: 3093: 3086: 3079: 3076: 3063: 3059: 3058: 3050: 3047: 3043: 3042:0-87170-282-7 3039: 3035: 3029: 3026: 3021: 3017: 3013: 3009: 3005: 3001: 2998:(11): 855–8. 2997: 2993: 2986: 2983: 2978: 2972: 2968: 2963: 2962: 2953: 2950: 2937: 2931: 2928: 2923: 2917: 2909: 2905: 2899: 2896: 2884: 2883: 2878: 2871: 2868: 2863: 2857: 2854: 2849: 2845: 2840: 2835: 2830: 2825: 2821: 2817: 2813: 2809: 2805: 2798: 2795: 2790: 2786: 2781: 2776: 2772: 2768: 2764: 2757: 2754: 2749: 2745: 2741: 2737: 2733: 2729: 2725: 2721: 2718:(4): 95–104. 2717: 2713: 2705: 2702: 2697: 2691: 2687: 2680: 2677: 2671: 2667: 2662: 2657: 2653: 2649: 2645: 2641: 2637: 2630: 2627: 2622: 2618: 2614: 2610: 2605: 2600: 2596: 2592: 2588: 2581: 2578: 2573: 2569: 2564: 2559: 2555: 2551: 2547: 2540: 2537: 2532: 2528: 2524: 2520: 2516: 2512: 2504: 2501: 2496: 2492: 2487: 2482: 2478: 2474: 2470: 2466: 2462: 2455: 2452: 2447: 2443: 2438: 2433: 2429: 2425: 2421: 2417: 2413: 2406: 2403: 2398: 2394: 2389: 2384: 2380: 2376: 2372: 2365: 2362: 2357: 2353: 2349: 2345: 2337: 2334: 2329: 2325: 2319: 2316: 2311: 2307: 2303: 2299: 2295: 2291: 2284: 2281: 2276: 2272: 2271: 2263: 2260: 2247: 2243: 2239: 2232: 2229: 2216: 2212: 2208: 2202: 2199: 2194: 2192:91-7486-581-1 2188: 2184: 2177: 2174: 2169: 2162: 2159: 2154: 2148: 2145: 2132: 2128: 2121: 2118: 2113: 2109: 2105: 2101: 2096: 2091: 2087: 2083: 2079: 2072: 2069: 2064: 2060: 2056: 2052: 2048: 2044: 2040: 2036: 2035: 2027: 2024: 2019: 2015: 2011: 2007: 2003: 1999: 1991: 1988: 1975: 1971: 1965: 1962: 1949: 1945: 1944:Distillations 1941: 1934: 1932: 1930: 1928: 1926: 1924: 1920: 1908: 1904: 1898: 1895: 1890: 1884: 1880: 1876: 1872: 1871: 1863: 1861: 1857: 1852: 1848: 1842: 1839: 1833: 1828: 1824: 1820: 1816: 1809: 1806: 1799: 1795: 1792: 1790: 1787: 1785: 1782: 1780: 1777: 1776: 1772: 1770: 1760: 1756: 1752: 1747: 1745: 1741: 1737: 1733: 1729: 1724: 1722: 1718: 1682: 1681: 1680: 1678: 1674: 1670: 1666: 1662: 1653: 1645: 1638: 1636: 1634: 1630: 1626: 1622: 1618: 1614: 1610: 1606: 1602: 1598: 1593: 1589: 1585: 1580: 1577: 1569: 1562: 1554: 1550: 1548: 1544: 1540: 1539:diethyl ether 1536: 1532: 1528: 1524: 1520: 1516: 1511: 1509: 1505: 1501: 1497: 1493: 1489: 1485: 1483: 1476: 1469: 1462: 1458: 1451: 1447: 1440: 1436: 1432: 1428: 1422: 1413: 1410: 1407: 1404: 1401: 1398: 1397: 1396: 1393: 1391: 1386: 1382: 1378: 1373: 1363: 1359: 1355: 1347: 1339: 1335: 1331: 1327: 1323: 1319: 1315: 1311: 1304: 1302: 1299: 1295: 1291: 1287: 1283: 1278: 1276: 1271: 1269: 1265: 1261: 1257: 1253: 1248: 1246: 1242: 1238: 1234: 1226: 1221: 1217: 1214: 1210: 1206: 1203: 1199: 1198: 1194: 1189: 1185: 1182: 1178: 1174: 1171: 1167: 1164: 1161: 1157: 1153: 1149: 1145: 1141: 1137: 1134: 1131: 1128:) is used in 1127: 1123: 1120: 1116: 1115: 1111: 1106: 1102: 1099: 1095: 1091: 1087: 1083: 1080: 1076: 1072: 1068: 1067:polyurethanes 1064: 1060: 1057: 1053: 1049: 1045: 1042: 1038: 1034: 1030: 1027: 1023: 1022: 1017: 1013: 1012: 1008: 1003: 999: 996: 992: 988: 985: 981: 977: 973: 972:blood banking 969: 966: 962: 958: 954: 950: 947: 944: 940: 936: 933: 929: 925: 921: 917: 914: 910: 906: 902: 899: 895: 891: 887: 883: 879: 875: 872: 868: 864: 863: 859: 854: 850: 847: 843: 839: 836: 832: 828: 824: 821: 817: 813: 810: 806: 802: 798: 797:Qin Shi Huang 794: 790: 787: 782: 781: 776: 772: 769: 765: 761: 760: 755: 748: 747: 743: 738: 732:Chemical uses 731: 725: 721: 717: 716:messenger RNA 713: 709: 705: 701: 697: 693: 690: 686: 682: 679: 675: 671: 670:periodontitis 667: 663: 659: 656: 652: 648: 644: 641: 637: 633: 629: 625: 621: 617: 613: 609: 605: 602: 598: 597: 595: 591: 583: 578: 576: 562: 558: 554: 550: 546: 542: 538: 534: 528: 424: 420: 408: 401: 396: 379: 373: 369: 367: 364: 363: 358: 353: 348: 345: 342: 338: 337: 334:Pharmacology 332: 328: 326: 323: 322: 319: 318: 315: 310: 308: 305: 304: 288: 285: 281: 280: 275: 267: 263: 262:DTXSID4027862 259: 258: 256: 246: 242: 241: 234: 230: 229: 227: 225: 222: 221: 218: 214: 212: 207: 206: 202: 198: 195: 193: 191:ECHA InfoCard 188: 187: 180: 179: 177: 175: 172: 171: 164: 163:ChEMBL1201478 160: 159: 157: 155: 152: 151: 147: 144: 143: 136: 132: 131: 129: 126: 122: 121: 116: 111: 104: 89: 85: 80: 76: 71: 67: 62: 56: 52: 45: 41: 37: 33: 19: 4136:Biomaterials 4100:Prucalopride 4085:Lubiprostone 3925: 3636:. 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Index

Polyethylene oxide
Ethylene glycol
Diethylene glycol
Polypropylene glycol
Propylene glycol
Macrogol

Polyethylene glycol 400
IUPAC names
macrogol
CAS Number
25322-68-3
ChEMBL
ChEMBL1201478
ChemSpider
ECHA InfoCard
100.105.546
Edit this at Wikidata
E number
(additional chemicals)
UNII
3WJQ0SDW1A
CompTox Dashboard
DTXSID4027862
Edit this at Wikidata
Chemical formula
Molar mass
Density
ATC code
A06AD15

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