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at dilutions of 0.05% to 0.5% v/v. These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific
727:
Ayorinde FO; Gelain SV; Johnson JH Jr; Wan LW. (2000). "Analysis of some commercial polysorbate formulations using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry".
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in a number of domestic, scientific, and pharmacological applications. As the name implies, the ethoxylation process leaves the molecule with 20
772:"Toxicological evaluation of some food additives including anticaking agents, antimicrobials, antioxidants, emulsifiers and thickening agents"
510:; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.
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to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
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mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.
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has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight.
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In biological techniques and sciences, polysorbate 20 has a broad range of applications. For example, it is used:
779:
562:
530:
676:
Chunhee Kim; You-Lo Hsieh (2001). "Wetting and absorbency of nonionic surfactant solutions on cotton fabrics".
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in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like
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to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
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557:. It helps to prevent non-specific antibody binding. In this major application, it is dissolved in
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Polysorbate 20 has been used as a shape directing agent to synthesize spheroidal
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monolaurate. Its stability and relative nontoxicity allows it to be used as a
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10.1002/1097-0231(20001130)14:22<2116::AID-RCM142>3.0.CO;2-1
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Polysorbate 20 is also used as wetting agent in rubber balers in the
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Except where otherwise noted, data are given for materials in their
704:"Polysorbates and Sorbitan Esters for Pharmaceutical Applications"
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Joint FAO/WHO Expert
Committee on Food Additives (1974).
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Polysorbate 20 is used in many brands of baby wipes.
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792:Q. Maqbool, C. Singh, A. Paul and A. Srivastava
290:> 100 °C (212 °F; 373 K)
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270:Clear, yellow to yellow-green viscous liquid.
8:
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607:in pharmaceutical applications to stabilize
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729:Rapid Communications in Mass Spectrometry
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43:Polyoxyethylene (20) sorbitan monolaurate
814:Tween 20 on biologists' wiki OpenWetWare
576:(PPD) solution used in skin testing for
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458:(common commercial brand names include
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394:110 °C (230 °F; 383 K)
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7:
619:Industrial and domestic applications
14:
421:
25:
776:WHO Food Additives Series No. 5
417:(at 25 °C , 100 kPa).
331:Occupational safety and health
1:
690:10.1016/S0927-7757(01)00653-7
603:Polysorbate 20 is used as an
518:Polysorbate 20 is used as a
599:Pharmaceutical applications
583:as a solubilizing agent of
574:purified protein derivative
63:PEG(20)sorbitan monolaurate
860:
626:Polysorbate 20 is used by
780:World Health Organization
563:phosphate buffered saline
537:Biotechnical applications
531:World Health Organization
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307:8.04×10 M at 21 °C
262:1226 g/mol
678:Colloids and Surfaces A
280:1.1 g/mL (approximate)
572:to stabilize proteins
545:as a washing agent in
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829:Non-ionic surfactants
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559:Tris-buffered saline
354:(fire diamond)
741:2000RCMS...14.2116A
508:polyethylene glycol
484:nonionic surfactant
21:
844:E-number additives
444:Infobox references
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16:Chemical substance
735:(22): 2116–2124.
526:and mint flavor.
514:Food applications
452:Chemical compound
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400:Safety data sheet
295:Surface tension:
196:CompTox Dashboard
152:(thickeners, ...)
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488:ethoxylation
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468:Alkest TW 20
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340:Main hazards
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159:RTECS number
81:Identifiers
66:Alkest TW 20
49:Other names
708:BASF Pharma
684:: 385–397.
613:suspensions
566:background.
480:polysorbate
390:Flash point
334:(OHS/OSH):
267:Appearance
228:Properties
132:100.105.528
57:Montanox 20
834:Excipients
823:Categories
713:2022-06-10
660:References
637:industry.
549:, such as
524:SD alcohol
500:emulsifier
476:Kotilen-20
258:Molar mass
184:239B50Y732
109:ChemSpider
88:CAS Number
72:Kotilen-20
40:IUPAC name
642:magnetite
635:elastomer
609:emulsions
605:excipient
496:detergent
344:Irritant
166:TR7400000
98:9005-64-5
796:, 2015,
757:11114018
648:See also
587:proteins
585:membrane
580:exposure
492:sorbitan
472:Tween 20
464:Scattics
351:NFPA 704
324:Hazards
145:E number
69:Tween 20
737:Bibcode
478:) is a
437:what is
435: (
276:Density
252:
800:, 1610
755:
592:lysing
555:ELISAs
482:-type
474:, and
432:verify
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402:(SDS)
34:Names
319:16.7
150:E432
753:PMID
611:and
590:for
553:and
529:The
498:and
175:UNII
116:none
745:doi
686:doi
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561:or
506:of
490:of
462:,
314:HLB
302:CMC
246:114
201:EPA
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688::
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248:O
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240:C
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199:(
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