1211:(Galβ1-3GalNAcα1-Ser/Thr) and negatively charged (NeuAcα2-3Galβ1-3GalNAcα1α1-Ser/Thr) sugar groups. About two thirds of these sugar groups are capped with sialic acid, and the end domains of the glycoprotein are thought to be globular, due to the nature of their protein-like domains. The N-terminus of lubricin is associated with its SMB-like domains, whereas the C-terminus is associated with the hemopexin-like domain. Due to the protein's overall slight negative charge and the fact that the center of the protein carries negatively charged sugar groups, the two end domains are thought to carry much of the protein's positive charge.
244:
221:
1231:
a number of studies have been conducted to mimic this. Researchers have successfully designed low-friction polymers imitating lubricin's bottle-brush-like structure, further supporting the notion that it is lubricin's architecture which plays an important role in reducing friction. Similarly, another study on zwitterionic polymer brushes, which intended to mimic the structure of bottle-brush polymers present in cartilage, found that the brushes produced super low fouling surfaces and super low friction surfaces.
118:
143:
1094:
1215:
495:
250:
149:
1207:, as both of these proteins contain a somatomedin B-like (SMB) domain and a hemopexin-like chain. These domains play a unique role in cell-cell and cell-extracellular matrix interactions. However, unlike vitronectin, lubricin carries a central mucin-like domain with a large number of repeating KEPAPTT motifs.
1230:
Shear studies of lubricin adsorbed between various hydrophilic and hydrophobic surfaces have confirmed the importance of the glycoprotein in boundary lubrication and wear protection in articular joints. Lubricin's bottle brush structure is common among a number of human lubricating glycoproteins, and
1486:
Flannery CR, Hughes CE, Schumacher BL, Tudor D, Aydelotte MB, Kuettner KE, Caterson B (January 1999). "Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective,
1222:
Lubricin's complex protein structure is termed "bottle brush," which refers to the large number of densely packed glycosylations on lubricin's backbone. Overall, lubricin's structure is similar to other mucin proteins and bottle brush polymers. This structure is key to its lubricating ability, which
1049:
growth, the gene responsible for the expression of lubricin was initially called "megakaryocyte-stimulating factor" (MSF). However, Lubricin, MSF, and SZP are now collectively known as
Proteoglycan 4 (hence PRG4 for the gene nomenclature). The evidence that lubricin is actually a proteoglycan is not
1226:
Furthermore, lubricin's N-terminus is thought to create disulfide bonds between two lubricin monomers. The glycoprotein thus exists as both a monomer and a dimer. The adsorption of lubricin to cartilage surfaces occurs through interactions on its N- and C- terminus, where its bottle brush structure
3370:
Lambiase A, Sullivan BD, Schmidt TA, Sullivan DA, Jay GD, Truitt ER, et al. (January 2017). "A Two-Week, Randomized, Double-masked Study to
Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye
1097:
The adhesion of
Lubricin's N- (blue) and C- (red) termini to two opposing cartilage surfaces undergoing shear stress (𝜏) and normal forces (𝐹_𝑁). Steric repulsion between mucin domains and hydration forces of the trapped solvent layer are thought to give lubricin its characteristic lubrication
1317:
has been shown to exhibit reduced levels of lubricin when compared to healthy patients. Researchers are currently exploring potential applications of lubricin for treating these and other related diseases. Thus far, adding supplement lubricin has been shown to restore the lubricating ability of
1210:
In total, lubricin is approximately 200 nm +/- 50 nm in length and has a diameter of a few nanometers. The glycoprotein consists of >5% serine and >20% threonine residues, which give rise to a large number of O-glycosylations. These are thought to contain short polar
1113:
Early work on lubricin showed that it was able to lubricate non cartilaginous surfaces as effectively as whole synovial fluid, confirming its important biological lubrication role. Understanding lubricin is key to understanding joint mechanics and friction-based diseases.
1318:
synovial fluid from patients with established osteoarthritis. Lubricin has been shown to also play a role in anti-inflammation for osteoarthritis patients. Additionally, reduced lubricin levels have also been observed in the synovial fluid of patients with
1223:
is ascribed to interchain repulsion. This leads to trapping of large quantities of solvent and the stabilization of a fluid-like cushioning layer, which enables bottle brush polymers to lower the friction between joints when external pressure is applied.
2088:
Su JL, Schumacher BL, Lindley KM, Soloveychik V, Burkhart W, Triantafillou JA, et al. (June 2001). "Detection of superficial zone protein in human and animal body fluids by cross-species monoclonal antibodies specific to superficial zone protein".
1227:
plays a role in both coating and repelling similarly coated cartilage surfaces due to steric repulsion. Lubricin's high degree of hydration is also thought to be involved in repulsion forces generated by lubricin between opposing cartilage surfaces.
3203:
Ludwig TE, McAllister JR, Lun V, Wiley JP, Schmidt TA (December 2012). "Diminished cartilage-lubricating ability of human osteoarthritic synovial fluid deficient in proteoglycan 4: Restoration through proteoglycan 4 supplementation".
3445:
Morawietz L, Gehrke T, Frommelt L, Gratze P, Bosio A, Möller J, et al. (July 2003). "Differential gene expression in the periprosthetic membrane: lubricin as a new possible pathogenetic factor in prosthesis loosening".
1183:
measurements show that the lubricin molecule is a partially extended flexible rod and, in solution, occupies a smaller spatial domain than would be expected from structural predictions. The large glycosylated region (i. e
1305:
application has been shown to induce an increased lubricin expression in tendons and septa of rat hindlimbs, which might suggest a beneficial lubricating effect for joints and tissues prone to wear and tear degradation.
1442:
Marcelino J, Carpten JD, Suwairi WM, Gutierrez OM, Schwartz S, Robbins C, et al. (November 1999). "CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome".
1285:
for autosomal recessive camptodactyly-arthropathy-coxa vara-pericarditis syndrome maps to chromosome 1q25-q31 where the PRG4 gene is located. Cell overgrowth may be primary to the pathogenesis of this protein.
2991:
Merberg DM et al. (1993) Comparison of vitronectin and megakaryocyte stimulating factor. In
Biology of Vitronectins and their Receptors. (Preissner et al., eds) pp45-52 (Elsevier Science, Amsterdam).
1681:
Rees SG, Davies JR, Tudor D, Flannery CR, Hughes CE, Dent CM, Caterson B (November 2002). "Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon".
3483:
Liu YJ, Lu SH, Xu B, Yang RC, Ren Q, Liu B, et al. (June 2004). "Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages".
3864:
2722:
Zappone B, Greene GW, Oroudjev E, Jay GD, Israelachvili JN (February 2008). "Molecular aspects of boundary lubrication by human lubricin: effect of disulfide bonds and enzymatic digestion".
1264:
1543:
Schumacher BL, Block JA, Schmid TM, Aydelotte MB, Kuettner KE (May 1994). "A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage".
3717:"Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage"
3001:
Taguchi M, Sun YL, Zhao C, Zobitz ME, Cha CJ, Jay GD, et al. (January 2008). "Lubricin surface modification improves extrasynovial tendon gliding in a canine model in vitro".
1042:. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Due to the discovery that the 32-kDa amino terminal fragment of lubricin could stimulate
1607:
Biology of vitronectins and their receptors : proceedings of the First
International Vitronectin Workshop, Rauischholzhausen Castle, Marburg, Germany, 25-28 August, 1993
3189:
257:
156:
1638:
Lord MS, Estrella RP, Chuang CY, Youssef P, Karlsson NG, Flannery CR, Whitelock JM (2012). "Not all lubricin isoforms are substituted with a glycosaminoglycan chain".
5779:
3857:
2916:
Banquy X, Burdyńska J, Lee DW, Matyjaszewski K, Israelachvili J (April 2014). "Bioinspired bottle-brush polymer exhibits low friction and
Amontons-like behavior".
6739:
1196:
that improves its lubricating property. Lubricin's unglycosylated regions can interact with cartilage proteins. This characteristic may aid in the molecule's
6395:
5543:
1218:
The basic "bottle brush" structure of lubricin, including its mucin, hemopexin-like and somatomedin B (SMB)-like domains. Figure created with BioRender.com
5160:
3850:
2012:
Jay GD, Lane BP, Sokoloff L (January 1992). "Characterization of a bovine synovial fluid lubricating factor. III. The interaction with hyaluronic acid".
79:
693:
674:
3036:
Zhang D, Kearney CJ, Cheriyan T, Schmid TM, Spector M (November 2011). "Extracorporeal shockwave-induced expression of lubricin in tendons and septa".
5218:
6080:
5770:
5375:
1716:
Schumacher BL, Schmidt TA, Voegtline MS, Chen AC, Sah RL (May 2005). "Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus".
1578:
Jay GD, Britt DE, Cha CJ (March 2000). "Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts".
1760:
Ikegawa S, Sano M, Koshizuka Y, Nakamura Y (2000). "Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes".
6806:
4360:
4043:
1329:
Lubricin, which is naturally present in human cornea-eyelid interface, has also been shown to play a key role in reducing friction between the
3241:"Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury"
6758:
6708:
6679:
6626:
5113:
4980:
1421:
1403:
6796:
6437:
6433:
6429:
6425:
3978:
3962:
2456:
Jay GD, Harris DA, Cha CJ (October 2001). "Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides".
3140:"The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid"
4706:
4625:
4492:
4409:
933:
243:
6421:
2502:
Schmidt TA, Plaas AH, Sandy JD (May 2009). "Disulfide-bonded multimers of proteoglycan 4 PRG4 are present in normal synovial fluids".
940:
3818:
1297:
plus lubricin significantly lowered the gliding resistance of the tendons. This research can aid in improving the gliding ability of
6110:
5229:
4789:
4400:
1614:
220:
1529:
4058:
4002:
3993:
1302:
2382:"Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin"
2131:"The O-glycomap of lubricin, a novel mucin responsible for joint lubrication, identified by site-specific glycopeptide analysis"
6632:
2341:"Cartilage oligomeric matrix protein forms protein complexes with synovial lubricin via non-covalent and covalent interactions"
1390:
1369:
2759:"Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface"
6719:
6695:
5835:
5391:
5254:
3428:
3412:"The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1"
3411:
2578:
Radin EL, Swann DA, Weisser PA (October 1970). "Separation of a hyaluronate-free lubricating fraction from synovial fluid".
1386:
142:
117:
6685:
3830:
2814:
Briscoe WH, Titmuss S, Tiberg F, Thomas RK, McGillivray DJ, Klein J (November 2006). "Boundary lubrication under water".
1365:
6729:
5125:
5007:
4997:
3081:"Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species"
59:
3596:"Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing"
2539:"Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing"
6075:
3290:"PA41 Traumatized knee joint synovial fluid fails to provide boundary lubrication among emergency department patients"
1275:
1240:
6100:
256:
155:
6714:
4540:
1319:
6095:
1293:
has also been studied. While adding lubricin alone fails to affect the tendon gliding resistance, the addition of
6622:
3631:"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry"
249:
148:
3079:
Kosinska MK, Ludwig TE, Liebisch G, Zhang R, Siebert HC, Wilhelm J, et al. (2015-05-01). Gualillo O (ed.).
1957:"Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoprotein"
1803:
Sun Y, Berger EJ, Zhao C, An KN, Amadio PC, Jay G (2006). "Mapping lubricin in canine musculoskeletal tissues".
4806:
4722:
4641:
4508:
4425:
738:
67:
4240:
1130:, and also by synovial lining cells. The cDNA encodes a protein of 1,404 amino acids (human A isoform) with a
6406:
4153:
4028:
719:
6085:
6801:
6690:
6306:
6210:
6070:
5830:
5249:
4235:
3873:
1169:
1151:
6764:
4961:
4605:
4245:
3884:
3183:
2185:"The molecular structure of lubricating glycoprotein-I, the boundary lubricant for articular cartilage"
1106:
family and similarly plays important roles in protecting cartilage surface from protein deposition and
1903:"The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth"
6704:
6090:
5022:
4971:
3771:
3533:
3092:
2823:
2770:
2696:
2587:
2393:
2237:
1968:
1310:
1197:
131:
5840:
3915:
1290:
46:
5845:
5259:
4956:
4148:
3836:
3824:
3323:"Transcription, translation, and function of lubricin, a boundary lubricant, at the ocular surface"
2226:"Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage"
1180:
1127:
912:
887:
883:
879:
875:
845:
824:
820:
816:
812:
4881:
3594:
Rhee DK, Marcelino J, Al-Mayouf S, Schelling DK, Bartels CF, Cui Y, et al. (September 2005).
2537:
Rhee DK, Marcelino J, Al-Mayouf S, Schelling DK, Bartels CF, Cui Y, et al. (September 2005).
6463:
6376:
6321:
6275:
6220:
5955:
5895:
5523:
4896:
4826:
4385:
3983:
3925:
3876:
3746:
3703:
3508:
3471:
3061:
2951:
Liu X, Dedinaite A, Rutland M, Thormann E, Visnevskij C, Makuska R, Claesson PM (November 2012).
2847:
2669:
2611:
2481:
1852:"Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity"
1828:
1785:
1741:
1663:
1468:
1055:
91:
6458:
6336:
6235:
6021:
5910:
5710:
5670:
5418:
5337:
5199:
5140:
5102:
5047:
5042:
5032:
4906:
4901:
4871:
4846:
4841:
4831:
4717:
4636:
4575:
4503:
4482:
4467:
4420:
4073:
3520:
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004).
3239:
Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, et al. (June 2008).
1294:
1093:
916:
891:
849:
808:
6558:
6416:
6351:
6331:
6250:
6230:
5945:
5925:
5905:
5548:
4876:
4600:
4133:
3930:
2339:
Flowers SA, Kalamajski S, Ali L, Björkman LI, Raj JR, Aspberg A, et al. (September 2017).
1850:
Jin C, Ekwall AK, Bylund J, Björkman L, Estrella RP, Whitelock JM, et al. (October 2012).
6381:
6371:
6326:
6280:
6270:
6225:
6150:
6049:
6016:
5996:
5960:
5950:
5900:
5860:
5332:
5312:
5279:
5062:
4911:
3799:
3738:
3695:
3660:
3617:
3582:
3561:
3500:
3463:
3433:
3388:
3352:
3270:
3221:
3171:
3120:
3053:
3018:
2974:
2933:
2898:
2839:
2796:
2739:
2661:
2603:
2560:
2519:
2473:
2411:
2362:
2318:
2263:
2206:
2162:
2106:
2070:
2029:
1994:
1932:
1883:
1820:
1777:
1733:
1698:
1655:
1620:
1610:
1587:
1560:
1504:
1460:
1015:
39:
6341:
6240:
6135:
6039:
5991:
5984:
5970:
5915:
5885:
5365:
5355:
5307:
5289:
5052:
4891:
4836:
3138:
Alquraini A, Garguilo S, D'Souza G, Zhang LX, Schmidt TA, Jay GD, Elsaid KA (December 2015).
6568:
5700:
3789:
3779:
3728:
3685:
3650:
3642:
3607:
3551:
3541:
3492:
3455:
3423:
3380:
3342:
3334:
3301:
3260:
3252:
3213:
3161:
3151:
3110:
3100:
3045:
3010:
2964:
2925:
2888:
2878:
2831:
2786:
2778:
2731:
2704:
2653:
2595:
2550:
2511:
2465:
2438:
2401:
2352:
2308:
2298:
2253:
2245:
2196:
2152:
2142:
2098:
2060:
2021:
1984:
1976:
1922:
1914:
1873:
1863:
1812:
1769:
1725:
1690:
1647:
1552:
1496:
1452:
1342:
1298:
1282:
1244:
1098:
ability. Two glycoprotein monomers are linked by a disulfide bond in yellow to form a dimer.
336:
267:
211:
166:
5092:
2281:
Flowers SA, Thomsson KA, Ali L, Huang S, Mthembu Y, Regmi SC, et al. (November 2020).
2224:
Reesink HL, Bonnevie ED, Liu S, Shurer CR, Hollander MJ, Bonassar LJ, Nixon AJ (May 2016).
6180:
2757:
Flowers SA, Zieba A, Örnros J, Jin C, Rolfson O, Björkman LI, et al. (October 2017).
2644:
Lee S, Spencer ND (February 2008). "Materials science. Sweet, hairy, soft, and slippery".
1338:
1110:, in inhibiting synovial cell overgrowth, and in preventing cartilage-cartilage adhesion.
494:
311:
87:
1122:
The protein encoded by this gene is a approximately 345 kDa specifically synthesized by
3775:
3537:
3096:
2827:
2774:
2700:
2591:
2397:
2287:
glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking"
2241:
1972:
6754:
6675:
6617:
6311:
6160:
6155:
5269:
5264:
3910:
3900:
3895:
3794:
3759:
3655:
3630:
3347:
3322:
3265:
3240:
3166:
3139:
3115:
3080:
2893:
2866:
2791:
2758:
2442:
2313:
2282:
2258:
2225:
2157:
2130:
1989:
1956:
1878:
1851:
1314:
1189:
1027:
3556:
3521:
3321:
Schmidt TA, Sullivan DA, Knop E, Richards SM, Knop N, Liu S, et al. (June 2013).
3306:
3289:
2201:
2184:
1927:
1902:
1901:
Rhee DK, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V, et al. (March 2005).
1694:
1322:
injuries, and decreased lubricating ability has been found in patients with traumatic
1214:
1050:
solid. The expression of lubricin has also been detected and the protein localized in
608:
603:
598:
593:
588:
572:
567:
562:
546:
541:
536:
6790:
6448:
6361:
6290:
6260:
6195:
6105:
6059:
5935:
5865:
5810:
5799:
5284:
4992:
4675:
4580:
4472:
3338:
2687:
de Gennes PG (September 1980). "Conformations of
Polymers Attached to an Interface".
2673:
1248:
1107:
1046:
523:
3842:
3707:
3475:
3410:
Bahabri SA, Suwairi WM, Laxer RM, Polinkovsky A, Dalaan AA, Warman ML (April 1998).
3065:
2485:
1832:
1789:
1472:
71:
6774:
6744:
6483:
6473:
6366:
6265:
6120:
5940:
5875:
5790:
5294:
5097:
4936:
4931:
4851:
4801:
4615:
4369:
4350:
4329:
4300:
4023:
4018:
3750:
3512:
2851:
2615:
1745:
1667:
1260:
1161:
1000:
329:
108:
1729:
3105:
2515:
2065:
2048:
1651:
95:
6734:
6700:
6598:
6588:
6583:
6573:
6523:
6346:
6245:
6006:
5920:
5850:
5745:
5508:
5473:
5423:
5386:
5322:
5204:
5135:
5087:
5077:
5072:
5067:
4951:
4946:
4941:
4319:
4230:
4220:
4188:
4183:
4178:
4173:
4163:
4123:
4088:
2380:
Raj A, Wang M, Liu C, Ali L, Karlsson NG, Claesson PM, Dėdinaitė A (June 2017).
1980:
1426:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1408:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1334:
1252:
1204:
1176:
1131:
1123:
1039:
3764:
Proceedings of the
National Academy of Sciences of the United States of America
3526:
Proceedings of the National Academy of Sciences of the United States of America
3496:
3384:
2867:"Regulation of lubricin for functional cartilage tissue regeneration: a review"
2782:
2406:
2381:
2357:
2340:
2102:
412:
6553:
6518:
6513:
6503:
6493:
6411:
6200:
6175:
6165:
6011:
5965:
5825:
5651:
5620:
5589:
5558:
5503:
5478:
5458:
5443:
5433:
5327:
5244:
5037:
5017:
4916:
4861:
4856:
4680:
4585:
4570:
4365:
4324:
4296:
4265:
4225:
4128:
4083:
4078:
4053:
4048:
4038:
3951:
3945:
3935:
3459:
3156:
3049:
2883:
2469:
2025:
1816:
1193:
1087:
228:
125:
75:
3629:
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006).
2303:
2129:
Ali L, Flowers SA, Jin C, Bennet EP, Ekwall AK, Karlsson NG (December 2014).
1624:
547:
extracellular matrix structural constituent conferring compression resistance
6578:
6548:
6543:
6538:
6533:
6528:
6508:
6498:
6488:
6478:
6170:
6130:
6026:
6001:
5760:
5755:
5750:
5740:
5735:
5730:
5720:
5641:
5579:
5513:
5493:
5488:
5483:
5468:
5463:
5453:
5448:
5342:
5317:
5082:
5002:
4921:
4866:
4756:
4695:
4685:
4590:
4477:
4275:
4270:
4260:
4168:
4158:
4143:
4118:
4113:
4103:
4098:
4093:
3784:
3546:
2657:
2147:
1868:
1323:
1272:
1268:
1256:
1143:
1031:
638:
472:
350:
295:
282:
194:
181:
83:
3803:
3742:
3699:
3664:
3621:
3612:
3595:
3586:
3573:
de Haan G (February 2005). "A novel growth factor encoded by an old gene".
3565:
3504:
3467:
3392:
3356:
3274:
3225:
3175:
3124:
3057:
3022:
2978:
2937:
2902:
2843:
2800:
2743:
2665:
2564:
2555:
2538:
2523:
2477:
2415:
2366:
2322:
2267:
2166:
2110:
2074:
1998:
1936:
1887:
1824:
1781:
1737:
1702:
1659:
1591:
1556:
1500:
1464:
3437:
2607:
2210:
2033:
1564:
1508:
980:
975:
6749:
6468:
6125:
5725:
5715:
5695:
5630:
5599:
5568:
5532:
5438:
5428:
4775:
4255:
4198:
4108:
4068:
3014:
1075:
1043:
964:
783:
764:
2835:
2708:
6724:
6145:
5610:
5012:
3973:
1165:
1146:
domain, and an aggregation domain. There are 3 consensus sequences for
1135:
750:
705:
3733:
3716:
3690:
3673:
3646:
3256:
3217:
2969:
2952:
2929:
2735:
2334:
2332:
2249:
1955:
Zappone B, Ruths M, Greene GW, Jay GD, Israelachvili JN (March 2007).
1773:
6637:
6301:
6190:
6115:
5820:
5815:
5239:
5234:
5188:
5184:
5180:
5176:
5172:
5168:
5164:
4816:
4355:
4033:
2599:
2429:
Jay GD (October 2004). "Lubricin and surfacing of articular joints".
1918:
1330:
1079:
1051:
948:
660:
3760:"The role of lubricin in the mechanical behavior of synovial fluid"
3522:"Large-scale characterization of HeLa cell nuclear phosphoproteins"
3429:
10.1002/1529-0131(199804)41:4<730::AID-ART22>3.0.CO;2-Y
1239:
Lubricin, as MSF, was detected in the urine of patients undergoing
1086:. It is present in human plasma, where it binds to neutrophils via
6669:
6665:
6661:
6657:
6653:
6649:
6645:
6641:
6356:
6255:
5930:
5870:
5684:
5407:
5403:
5399:
5395:
4886:
4750:
4669:
4665:
4564:
4560:
4556:
4552:
4461:
4457:
4308:
3758:
Jay GD, Torres JR, Warman ML, Laderer MC, Breuer KS (April 2007).
1456:
1213:
1185:
1139:
1103:
1092:
1067:
1063:
1035:
1011:
623:
619:
6140:
4746:
4742:
4738:
4734:
4730:
4726:
4661:
4657:
4653:
4649:
4645:
4548:
4544:
4536:
4532:
4528:
4524:
4520:
4516:
4512:
4453:
4449:
4445:
4441:
4437:
4433:
4429:
4381:
4377:
4373:
4339:
4304:
4285:
3672:
Alazami AM, Al-Mayouf SM, Wyngaard CA, Meyer B (February 2006).
1083:
1071:
1059:
1007:
503:
63:
3846:
1247:. Depletion of lubricin function has also been associated with
1102:
Lubricin shares many properties with other members of the
2049:"The biology of lubricin: near frictionless joint motion"
2630:
319:
50:, CACP, HAPO, JCAP, MSF, SZP, bG174L6.2, proteoglycan 4
6740:
Pituitary adenylate cyclase-activating peptide (PACAP)
3674:"Novel PRG4 mutations underlie CACP in Saudi families"
3003:
The Journal of Bone and Joint Surgery. American Volume
2504:
Biochimica et Biophysica Acta (BBA) - General Subjects
1487:
and lubricating properties in cartilage metabolism".
484:
3715:
Zhang D, Johnson LJ, Hsu HP, Spector M (July 2007).
1164:
that consists of approximately equal proportions of
1030:
and on the surface (superficial layer) of articular
6607:
6394:
6289:
6058:
5798:
5789:
5769:
5683:
5660:
5629:
5598:
5567:
5531:
5522:
5374:
5217:
5150:
5112:
4979:
4970:
4788:
4765:
4705:
4624:
4491:
4408:
4399:
4338:
4284:
4197:
4001:
3992:
3961:
3883:
1489:
Biochemical and Biophysical Research Communications
905:
868:
838:
801:
6686:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5544:Glial cell line-derived neurotrophic factor (GDNF)
5197:Cleavage products/derivatives with unknown target:
2953:"Electrostatically anchored branched brush layers"
1382:
1380:
1378:
1361:
1359:
1357:
1345:disease have thus far been relatively successful.
1309:Furthermore, the synovial fluid of patients with
266:
165:
6720:Macrophage-stimulating protein (MSP; HLP, HGFLP)
1437:
1435:
4361:Heparin-binding EGF-like growth factor (HB-EGF)
4044:Heparin-binding EGF-like growth factor (HB-EGF)
1168:and oligosaccharides. The oligosaccharides are
1387:GRCm38: Ensembl release 89: ENSMUSG00000006014
6772:Additional growth factor receptor modulators:
3858:
3188:: CS1 maint: DOI inactive as of April 2024 (
2183:Swann DA, Slayter HS, Silver FH (June 1981).
1192:protein. In synovial fluid it interacts with
8:
5126:Insulin-like growth factor-2 (somatomedin A)
5008:Insulin-like growth factor-2 (somatomedin A)
4998:Insulin-like growth factor-1 (somatomedin C)
2124:
2122:
2120:
1845:
1843:
1366:GRCh38: Ensembl release 89: ENSG00000116690
1150:-glycosylation and more than 168 sites for
5795:
5528:
4976:
4405:
3998:
3865:
3851:
3843:
1337:of the eye. Clinical trials of the use of
634:
519:
307:
206:
103:
3793:
3783:
3732:
3689:
3654:
3611:
3555:
3545:
3427:
3346:
3305:
3264:
3165:
3155:
3114:
3104:
2968:
2892:
2882:
2790:
2554:
2405:
2356:
2312:
2302:
2257:
2200:
2156:
2146:
2064:
1988:
1926:
1877:
1867:
1034:and therefore plays an important role in
6730:Migration-stimulating factor (MSF; PRG4)
3288:Jay GD, Zack J, Cha C (September 2001).
2918:Journal of the American Chemical Society
2386:Journal of Colloid and Interface Science
1524:
1522:
1520:
1518:
573:collagen-containing extracellular matrix
4059:Transforming growth factor alpha (TGFα)
1545:Archives of Biochemistry and Biophysics
1353:
1188:) of lubricin makes it a water-soluble
6633:Connective tissue growth factor (CTGF)
3181:
2865:Lee Y, Choi J, Hwang NS (2018-03-16).
1950:
1948:
1946:
20:
6696:Hepatoma-derived growth factor (HDGF)
2497:
2495:
2178:
2176:
1907:The Journal of Clinical Investigation
271:
232:
227:
170:
129:
124:
7:
1341:lubricin eye drops for treatment of
3600:The Journal of Biological Chemistry
2543:The Journal of Biological Chemistry
2291:The Journal of Biological Chemistry
2189:The Journal of Biological Chemistry
2135:Molecular & Cellular Proteomics
1856:The Journal of Biological Chemistry
459:medial head of gastrocnemius muscle
2443:10.1097/01.bco.0000136127.00043.a8
2047:Jay GD, Waller KA (October 2014).
1530:"Entrez Gene: PRG4 proteoglycan 4"
902:
865:
835:
798:
774:
755:
729:
710:
684:
665:
489:
407:
345:
324:
14:
1003:that in humans is encoded by the
6715:Leukemia inhibitory factor (LIF)
3339:10.1001/jamaophthalmol.2013.2385
3144:Arthritis Research & Therapy
1303:Extracorporeal shockwave therapy
493:
255:
248:
242:
219:
154:
147:
141:
116:
5883:Negative allosteric modulators:
3721:Journal of Orthopaedic Research
2431:Current Opinion in Orthopaedics
1718:Journal of Orthopaedic Research
6201:Gossypetin (3,5,7,8,3',4'-HHF)
5392:Platelet-derived growth factor
1762:Cytogenetics and Cell Genetics
1203:Lubricin is a close analog to
504:More reference expression data
473:More reference expression data
1:
6807:Extracellular matrix proteins
6407:Placental growth factor (PGF)
3307:10.1016/s1063-4584(01)80293-4
2202:10.1016/S0021-9258(19)69297-5
1730:10.1016/j.orthres.2004.11.011
1695:10.1016/S0945-053X(02)00056-2
1289:Lubricin’s role in improving
594:receptor-mediated endocytosis
589:cell population proliferation
240:
139:
16:Proteoglycan; lubricant; gene
6691:Glia maturation factor (GMF)
5200:Glypromate (GPE, (1-3)IGF-1)
3635:Journal of Proteome Research
3294:Osteoarthritis and Cartilage
3106:10.1371/journal.pone.0125192
2629:Created with Biorender.com.
2516:10.1016/j.bbagen.2009.03.016
2345:Osteoarthritis and Cartilage
2066:10.1016/j.matbio.2014.08.008
1652:10.3109/03008207.2011.614364
1609:. Elsevier. pp. 45–52.
6797:Genes on human chromosome 1
3823:human gene location in the
1981:10.1529/biophysj.106.088799
1580:The Journal of Rheumatology
1241:bone marrow transplantation
1138:-binding domains, multiple
537:scavenger receptor activity
6823:
6623:Colony-stimulating factors
6615:Additional growth factors:
3835:human gene details in the
3497:10.1182/blood-2003-06-1825
3385:10.1016/j.jtos.2016.08.004
2783:10.1038/s41598-017-13558-y
2407:10.1016/j.jcis.2017.02.007
2358:10.1016/j.joca.2017.03.016
2103:10.1089/027245701750293475
2014:Connective Tissue Research
1805:Connective Tissue Research
1640:Connective Tissue Research
1126:located at the surface of
604:vesicle-mediated transport
5971:SNA-120 (pegylated K252a)
5143:(against IGF-1 and IGF-2)
5105:(against IGF-1 and IGF-2)
3460:10.1007/s00428-003-0818-y
3157:10.1186/s13075-015-0877-x
3050:10.1007/s00441-011-1258-7
2884:10.1186/s40824-018-0118-x
2026:10.3109/03008209209016818
1817:10.1080/03008200600846754
1422:"Mouse PubMed Reference:"
1404:"Human PubMed Reference:"
1243:during a period of acute
1038:lubrication and synovial
979:
974:
970:
963:
947:
941:Chr 1: 150.45 – 150.47 Mb
928:
909:
872:
861:
842:
805:
794:
781:
777:
762:
758:
749:
736:
732:
717:
713:
704:
691:
687:
672:
668:
659:
644:
637:
633:
617:
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
4807:Hepatocyte growth factor
4366:Neuregulins (heregulins)
4297:Neuregulins (heregulins)
4241:Trastuzumab duocarmazine
3954:(against angiopoietin 2)
3948:(against angiopoietin 3)
3416:Arthritis and Rheumatism
3245:Arthritis and Rheumatism
3206:Arthritis and Rheumatism
3038:Cell and Tissue Research
2304:10.1074/jbc.RA120.012882
934:Chr 1: 186.3 – 186.31 Mb
4154:Depatuxizumab mafodotin
3785:10.1073/pnas.0608558104
3547:10.1073/pnas.0404720101
3160:(inactive 2024-04-10).
2658:10.1126/science.1153273
2470:10.1023/a:1021159619373
2148:10.1074/mcp.M114.040865
1869:10.1074/jbc.M112.363119
1026:Lubricin is present in
6777:(neurotrophin mixture)
6765:Wnt signaling proteins
6446:Allosteric modulators:
6166:Norwogonin (5,7,8-THF)
4386:5 (tomoregulin, TMEFF)
4236:Trastuzumab deruxtecan
3874:Growth factor receptor
3613:10.1074/jbc.M505401200
2556:10.1074/jbc.M505401200
2458:Glycoconjugate Journal
1557:10.1006/abbi.1994.1219
1501:10.1006/bbrc.1998.0104
1219:
1175:both with and without
1099:
542:polysaccharide binding
6705:T-cell growth factors
4962:Telisotuzumab vedotin
4246:Trastuzumab emtansine
2871:Biomaterials Research
1605:Preissner KT (1993).
1235:Clinical significance
1217:
1155:-linked glycosylation
1096:
439:stroma of bone marrow
5290:EVT-901 (SAR-127963)
5023:Mecasermin rinfabate
3015:10.2106/JBJS.G.00045
2283:"Decrease of core 2
1311:rheumatoid arthritis
1198:boundary lubricating
1160:Lubricin is a large
568:extracellular matrix
563:extracellular region
234:Chromosome 1 (mouse)
132:Chromosome 1 (human)
3837:UCSC Genome Browser
3825:UCSC Genome Browser
3776:2007PNAS..104.6194J
3538:2004PNAS..10112130B
3097:2015PLoSO..1025192K
2836:10.1038/nature05196
2828:2006Natur.444..191B
2775:2017NatSR...713149F
2709:10.1021/ma60077a009
2701:1980MaMol..13.1069D
2592:1970Natur.228..377R
2398:2017JCIS..495..200R
2297:(47): 16023–16036.
2242:2016NatSR...625463R
1973:2007BpJ....92.1693Z
1961:Biophysical Journal
1181:Electron microscope
1128:articular cartilage
389:islet of Langerhans
385:germinal epithelium
381:right lobe of liver
6456:Kinase inhibitors:
6319:Kinase inhibitors:
6218:Kinase inhibitors:
5893:Kinase inhibitors:
5708:Kinase inhibitors:
5668:Kinase inhibitors:
5649:Kinase inhibitors:
5618:Kinase inhibitors:
5587:Kinase inhibitors:
5556:Kinase inhibitors:
5416:Kinase inhibitors:
5030:Kinase inhibitors:
4824:Kinase inhibitors:
4613:Kinase inhibitors:
4606:Aprutumab ixadotin
4253:Kinase inhibitors:
4066:Kinase inhibitors:
3923:Kinase inhibitors:
3373:The Ocular Surface
3327:JAMA Ophthalmology
2763:Scientific Reports
2230:Scientific Reports
1276:recessive disorder
1220:
1100:
739:ENSMUSG00000006014
582:Biological process
556:Cellular component
530:Molecular function
455:left lobe of liver
435:intercostal muscle
427:tibiofemoral joint
6784:
6783:
6390:
6389:
6151:N-Acetylserotonin
6050:ReN-1820 (TrkAd5)
5679:
5678:
5213:
5212:
5158:Binding proteins:
4817:Dihexa (PNB-0408)
4784:
4783:
4395:
4394:
4309:6 (neuroglycan C)
4029:EGF (urogastrone)
4007:
3734:10.1002/jor.20344
3691:10.1002/humu.9399
3647:10.1021/pr0502065
3257:10.1002/art.23495
3218:10.1002/art.34674
2970:10.1021/la3028989
2930:10.1021/ja501770y
2736:10.1021/la702383n
2250:10.1038/srep25463
1774:10.1159/000056791
1301:done clinically.
1142:-like repeats, a
1134:homology domain,
990:
989:
986:
985:
959:
958:
924:
923:
899:
898:
857:
856:
832:
831:
790:
789:
771:
770:
745:
744:
726:
725:
700:
699:
681:
680:
629:
628:
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
373:synovial membrane
302:
301:
201:
200:
6814:
6596:Decoy receptors:
6569:Alacizumab pegol
6047:Decoy receptors:
5796:
5701:Stem cell factor
5642:Persephin (PSPN)
5580:Neurturin (NRTN)
5529:
5366:LEVI-04 (p75-Fc)
5363:Decoy receptors:
4977:
4406:
4005:
3999:
3867:
3860:
3853:
3844:
3807:
3797:
3787:
3754:
3736:
3711:
3693:
3668:
3658:
3625:
3615:
3606:(35): 31325–32.
3590:
3569:
3559:
3549:
3516:
3479:
3441:
3431:
3397:
3396:
3367:
3361:
3360:
3350:
3318:
3312:
3311:
3309:
3285:
3279:
3278:
3268:
3236:
3230:
3229:
3200:
3194:
3193:
3187:
3179:
3169:
3159:
3135:
3129:
3128:
3118:
3108:
3076:
3070:
3069:
3033:
3027:
3026:
2998:
2992:
2989:
2983:
2982:
2972:
2963:(44): 15537–47.
2948:
2942:
2941:
2924:(17): 6199–202.
2913:
2907:
2906:
2896:
2886:
2862:
2856:
2855:
2811:
2805:
2804:
2794:
2754:
2748:
2747:
2719:
2713:
2712:
2695:(5): 1069–1075.
2684:
2678:
2677:
2641:
2635:
2634:
2626:
2620:
2619:
2600:10.1038/228377a0
2575:
2569:
2568:
2558:
2549:(35): 31325–32.
2534:
2528:
2527:
2499:
2490:
2489:
2453:
2447:
2446:
2426:
2420:
2419:
2409:
2377:
2371:
2370:
2360:
2351:(9): 1496–1504.
2336:
2327:
2326:
2316:
2306:
2278:
2272:
2271:
2261:
2221:
2215:
2214:
2204:
2180:
2171:
2170:
2160:
2150:
2141:(12): 3396–409.
2126:
2115:
2114:
2085:
2079:
2078:
2068:
2044:
2038:
2037:
2009:
2003:
2002:
1992:
1952:
1941:
1940:
1930:
1919:10.1172/JCI22263
1898:
1892:
1891:
1881:
1871:
1862:(43): 35922–33.
1847:
1838:
1836:
1800:
1794:
1793:
1757:
1751:
1749:
1713:
1707:
1706:
1678:
1672:
1671:
1635:
1629:
1628:
1602:
1596:
1595:
1575:
1569:
1568:
1540:
1534:
1533:
1526:
1513:
1512:
1483:
1477:
1476:
1439:
1430:
1429:
1418:
1412:
1411:
1400:
1394:
1384:
1373:
1363:
1245:thrombocytopenia
1010:. It acts as a
972:
971:
943:
936:
919:
903:
894:
866:
862:RefSeq (protein)
852:
836:
827:
799:
775:
756:
730:
711:
685:
666:
635:
520:
506:
497:
490:
475:
443:semi-lunar valve
415:
413:Top expressed in
408:
393:popliteal artery
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
96:PRG4 - orthologs
49:
42:
21:
6822:
6821:
6817:
6816:
6815:
6813:
6812:
6811:
6787:
6786:
6785:
6780:
6725:Midkine (NEGF2)
6603:
6386:
6285:
6054:
5992:ABT-110 (PG110)
5785:
5765:
5675:
5656:
5625:
5594:
5563:
5518:
5370:
5308:ABT-110 (PG110)
5209:
5146:
5108:
4966:
4780:
4761:
4701:
4698:(against FGF23)
4620:
4487:
4391:
4334:
4280:
4193:
4004:
3988:
3957:
3879:
3871:
3815:
3810:
3757:
3714:
3671:
3628:
3593:
3572:
3532:(33): 12130–5.
3519:
3491:(12): 4449–56.
3482:
3448:Virchows Archiv
3444:
3409:
3405:
3403:Further reading
3400:
3369:
3368:
3364:
3320:
3319:
3315:
3287:
3286:
3282:
3238:
3237:
3233:
3212:(12): 3963–71.
3202:
3201:
3197:
3180:
3137:
3136:
3132:
3091:(5): e0125192.
3078:
3077:
3073:
3035:
3034:
3030:
3000:
2999:
2995:
2990:
2986:
2950:
2949:
2945:
2915:
2914:
2910:
2864:
2863:
2859:
2822:(7116): 191–4.
2813:
2812:
2808:
2756:
2755:
2751:
2730:(4): 1495–508.
2721:
2720:
2716:
2686:
2685:
2681:
2652:(5863): 575–6.
2643:
2642:
2638:
2628:
2627:
2623:
2586:(5269): 377–8.
2577:
2576:
2572:
2536:
2535:
2531:
2501:
2500:
2493:
2455:
2454:
2450:
2428:
2427:
2423:
2379:
2378:
2374:
2338:
2337:
2330:
2280:
2279:
2275:
2223:
2222:
2218:
2182:
2181:
2174:
2128:
2127:
2118:
2087:
2086:
2082:
2046:
2045:
2041:
2011:
2010:
2006:
1967:(5): 1693–708.
1954:
1953:
1944:
1900:
1899:
1895:
1849:
1848:
1841:
1802:
1801:
1797:
1759:
1758:
1754:
1715:
1714:
1710:
1680:
1679:
1675:
1637:
1636:
1632:
1617:
1604:
1603:
1599:
1577:
1576:
1572:
1542:
1541:
1537:
1528:
1527:
1516:
1485:
1484:
1480:
1445:Nature Genetics
1441:
1440:
1433:
1420:
1419:
1415:
1402:
1401:
1397:
1385:
1376:
1364:
1355:
1351:
1237:
1120:
1024:
981:View/Edit Mouse
976:View/Edit Human
939:
932:
929:Location (UCSC)
915:
911:
890:
886:
882:
878:
874:
848:
844:
823:
819:
815:
811:
807:
720:ENSG00000116690
613:
599:immune response
577:
551:
502:
471:
462:
457:
453:
451:muscle of thigh
449:
445:
441:
437:
433:
429:
425:
411:
400:
397:tibial arteries
395:
391:
387:
383:
379:
377:parietal pleura
375:
371:
367:
365:Achilles tendon
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
6820:
6818:
6810:
6809:
6804:
6799:
6789:
6788:
6782:
6781:
6779:
6778:
6768:
6767:
6762:
6755:Thrombopoietin
6752:
6747:
6742:
6737:
6732:
6727:
6722:
6717:
6712:
6698:
6693:
6688:
6683:
6676:Erythropoietin
6673:
6635:
6630:
6620:
6618:Adrenomedullin
6611:
6609:
6605:
6604:
6602:
6601:
6592:
6591:
6586:
6581:
6576:
6571:
6562:
6561:
6556:
6551:
6546:
6541:
6536:
6531:
6526:
6521:
6516:
6511:
6506:
6501:
6496:
6491:
6486:
6481:
6476:
6471:
6466:
6461:
6452:
6451:
6442:
6441:
6419:
6414:
6409:
6400:
6398:
6392:
6391:
6388:
6387:
6385:
6384:
6379:
6374:
6369:
6364:
6359:
6354:
6349:
6344:
6339:
6334:
6329:
6324:
6315:
6314:
6309:
6304:
6295:
6293:
6287:
6286:
6284:
6283:
6278:
6273:
6268:
6263:
6258:
6253:
6248:
6243:
6238:
6233:
6228:
6223:
6214:
6213:
6204:
6203:
6198:
6193:
6184:
6183:
6178:
6173:
6168:
6163:
6158:
6153:
6148:
6143:
6138:
6133:
6128:
6123:
6118:
6113:
6108:
6103:
6098:
6093:
6088:
6083:
6081:4'-DMA-7,8-DHF
6078:
6073:
6064:
6062:
6056:
6055:
6053:
6052:
6043:
6042:
6030:
6029:
6024:
6019:
6014:
6009:
6004:
5999:
5994:
5975:
5974:
5968:
5963:
5958:
5953:
5948:
5943:
5938:
5933:
5928:
5923:
5918:
5913:
5908:
5903:
5898:
5889:
5888:
5879:
5878:
5873:
5868:
5863:
5854:
5853:
5848:
5843:
5841:Gambogic amide
5838:
5833:
5828:
5823:
5818:
5813:
5804:
5802:
5793:
5787:
5786:
5784:
5783:
5775:
5773:
5767:
5766:
5764:
5763:
5758:
5753:
5748:
5743:
5738:
5733:
5728:
5723:
5718:
5713:
5704:
5703:
5698:
5689:
5687:
5681:
5680:
5677:
5676:
5674:
5673:
5664:
5662:
5658:
5657:
5655:
5654:
5645:
5644:
5635:
5633:
5627:
5626:
5624:
5623:
5614:
5613:
5611:Artemin (ARTN)
5604:
5602:
5596:
5595:
5593:
5592:
5583:
5582:
5573:
5571:
5565:
5564:
5562:
5561:
5552:
5551:
5546:
5537:
5535:
5526:
5520:
5519:
5517:
5516:
5511:
5506:
5497:
5496:
5491:
5486:
5481:
5476:
5471:
5466:
5461:
5456:
5451:
5446:
5441:
5436:
5431:
5426:
5421:
5412:
5411:
5389:
5380:
5378:
5372:
5371:
5369:
5368:
5359:
5358:
5346:
5345:
5340:
5335:
5330:
5325:
5320:
5315:
5310:
5298:
5297:
5292:
5287:
5282:
5273:
5272:
5267:
5262:
5257:
5252:
5247:
5242:
5237:
5232:
5223:
5221:
5215:
5214:
5211:
5210:
5208:
5207:
5202:
5193:
5192:
5154:
5152:
5148:
5147:
5145:
5144:
5138:
5129:
5128:
5118:
5116:
5110:
5109:
5107:
5106:
5100:
5095:
5090:
5085:
5080:
5075:
5070:
5065:
5056:
5055:
5050:
5045:
5040:
5035:
5026:
5025:
5020:
5015:
5010:
5005:
5000:
4995:
4985:
4983:
4974:
4968:
4967:
4965:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4925:
4924:
4919:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4874:
4869:
4864:
4859:
4854:
4849:
4844:
4839:
4834:
4829:
4820:
4819:
4810:
4809:
4804:
4794:
4792:
4786:
4785:
4782:
4781:
4779:
4778:
4769:
4767:
4763:
4762:
4760:
4759:
4754:
4720:
4711:
4709:
4703:
4702:
4700:
4699:
4689:
4688:
4683:
4678:
4673:
4639:
4630:
4628:
4622:
4621:
4619:
4618:
4609:
4608:
4603:
4594:
4593:
4588:
4583:
4578:
4573:
4568:
4506:
4497:
4495:
4489:
4488:
4486:
4485:
4480:
4475:
4470:
4465:
4423:
4414:
4412:
4403:
4397:
4396:
4393:
4392:
4390:
4389:
4363:
4358:
4353:
4344:
4342:
4336:
4335:
4333:
4332:
4327:
4322:
4313:
4312:
4290:
4288:
4282:
4281:
4279:
4278:
4273:
4268:
4263:
4258:
4249:
4248:
4243:
4238:
4233:
4228:
4223:
4214:
4213:
4203:
4201:
4195:
4194:
4192:
4191:
4186:
4181:
4176:
4171:
4166:
4161:
4156:
4151:
4146:
4137:
4136:
4131:
4126:
4121:
4116:
4111:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4071:
4062:
4061:
4056:
4051:
4046:
4041:
4036:
4031:
4026:
4021:
4011:
4009:
3996:
3990:
3989:
3987:
3986:
3981:
3976:
3967:
3965:
3959:
3958:
3956:
3955:
3949:
3939:
3938:
3933:
3928:
3919:
3918:
3916:Angiopoietin 3
3913:
3911:Angiopoietin 2
3904:
3903:
3901:Angiopoietin 4
3898:
3896:Angiopoietin 1
3889:
3887:
3881:
3880:
3872:
3870:
3869:
3862:
3855:
3847:
3841:
3840:
3828:
3814:
3813:External links
3811:
3809:
3808:
3770:(15): 6194–9.
3755:
3712:
3678:Human Mutation
3669:
3641:(6): 2070–80.
3626:
3591:
3570:
3517:
3480:
3442:
3406:
3404:
3401:
3399:
3398:
3362:
3313:
3280:
3251:(6): 1707–15.
3231:
3195:
3130:
3071:
3028:
2993:
2984:
2943:
2908:
2857:
2806:
2749:
2714:
2689:Macromolecules
2679:
2636:
2621:
2570:
2529:
2491:
2464:(10): 807–15.
2448:
2437:(5): 355–359.
2421:
2372:
2328:
2273:
2216:
2195:(11): 5921–5.
2172:
2116:
2080:
2053:Matrix Biology
2039:
2004:
1942:
1893:
1839:
1795:
1768:(3–4): 291–7.
1752:
1708:
1689:(7): 593–602.
1683:Matrix Biology
1673:
1630:
1615:
1597:
1586:(3): 594–600.
1570:
1535:
1514:
1478:
1431:
1413:
1395:
1374:
1352:
1350:
1347:
1315:osteoarthritis
1291:tendon gliding
1236:
1233:
1190:synovial fluid
1119:
1116:
1028:synovial fluid
1023:
1020:
993:Proteoglycan 4
988:
987:
984:
983:
978:
968:
967:
961:
960:
957:
956:
954:
952:
945:
944:
937:
930:
926:
925:
922:
921:
907:
906:
900:
897:
896:
870:
869:
863:
859:
858:
855:
854:
840:
839:
833:
830:
829:
803:
802:
796:
792:
791:
788:
787:
779:
778:
772:
769:
768:
760:
759:
753:
747:
746:
743:
742:
734:
733:
727:
724:
723:
715:
714:
708:
702:
701:
698:
697:
689:
688:
682:
679:
678:
670:
669:
663:
657:
656:
651:
646:
642:
641:
631:
630:
627:
626:
615:
614:
612:
611:
606:
601:
596:
591:
585:
583:
579:
578:
576:
575:
570:
565:
559:
557:
553:
552:
550:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
361:synovial joint
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
6819:
6808:
6805:
6803:
6802:Proteoglycans
6800:
6798:
6795:
6794:
6792:
6776:
6773:
6770:
6769:
6766:
6763:
6760:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6718:
6716:
6713:
6710:
6706:
6702:
6699:
6697:
6694:
6692:
6689:
6687:
6684:
6681:
6677:
6674:
6671:
6667:
6663:
6659:
6655:
6651:
6647:
6643:
6639:
6636:
6634:
6631:
6628:
6624:
6621:
6619:
6616:
6613:
6612:
6610:
6606:
6600:
6597:
6594:
6593:
6590:
6587:
6585:
6582:
6580:
6577:
6575:
6572:
6570:
6567:
6564:
6563:
6560:
6557:
6555:
6552:
6550:
6547:
6545:
6542:
6540:
6537:
6535:
6532:
6530:
6527:
6525:
6522:
6520:
6517:
6515:
6512:
6510:
6507:
6505:
6502:
6500:
6497:
6495:
6492:
6490:
6487:
6485:
6482:
6480:
6477:
6475:
6472:
6470:
6467:
6465:
6462:
6460:
6457:
6454:
6453:
6450:
6449:Cyclotraxin B
6447:
6444:
6443:
6439:
6435:
6431:
6427:
6423:
6420:
6418:
6415:
6413:
6410:
6408:
6405:
6402:
6401:
6399:
6397:
6393:
6383:
6380:
6378:
6375:
6373:
6370:
6368:
6365:
6363:
6362:Larotrectinib
6360:
6358:
6355:
6353:
6350:
6348:
6345:
6343:
6340:
6338:
6335:
6333:
6330:
6328:
6325:
6323:
6320:
6317:
6316:
6313:
6310:
6308:
6305:
6303:
6300:
6297:
6296:
6294:
6292:
6288:
6282:
6279:
6277:
6274:
6272:
6269:
6267:
6264:
6262:
6261:Larotrectinib
6259:
6257:
6254:
6252:
6249:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6216:
6215:
6212:
6209:
6206:
6205:
6202:
6199:
6197:
6196:Cyclotraxin B
6194:
6192:
6189:
6186:
6185:
6182:
6179:
6177:
6174:
6172:
6169:
6167:
6164:
6162:
6159:
6157:
6154:
6152:
6149:
6147:
6144:
6142:
6139:
6137:
6134:
6132:
6129:
6127:
6124:
6122:
6119:
6117:
6114:
6112:
6109:
6107:
6106:Amitriptyline
6104:
6102:
6099:
6097:
6094:
6092:
6089:
6087:
6084:
6082:
6079:
6077:
6074:
6072:
6069:
6066:
6065:
6063:
6061:
6057:
6051:
6048:
6045:
6044:
6041:
6038:
6035:
6032:
6031:
6028:
6025:
6023:
6020:
6018:
6015:
6013:
6010:
6008:
6005:
6003:
6000:
5998:
5995:
5993:
5990:
5986:
5983:
5982:Against TrkA:
5980:
5977:
5976:
5972:
5969:
5967:
5964:
5962:
5959:
5957:
5954:
5952:
5949:
5947:
5944:
5942:
5939:
5937:
5936:Larotrectinib
5934:
5932:
5929:
5927:
5924:
5922:
5919:
5917:
5914:
5912:
5909:
5907:
5904:
5902:
5899:
5897:
5894:
5891:
5890:
5887:
5884:
5881:
5880:
5877:
5874:
5872:
5869:
5867:
5866:Dexamethasone
5864:
5862:
5859:
5856:
5855:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5827:
5824:
5822:
5819:
5817:
5814:
5812:
5811:Amitriptyline
5809:
5806:
5805:
5803:
5801:
5797:
5794:
5792:
5788:
5781:
5777:
5776:
5774:
5772:
5768:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5742:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5719:
5717:
5714:
5712:
5709:
5706:
5705:
5702:
5699:
5697:
5694:
5691:
5690:
5688:
5686:
5682:
5672:
5669:
5666:
5665:
5663:
5659:
5653:
5650:
5647:
5646:
5643:
5640:
5637:
5636:
5634:
5632:
5628:
5622:
5619:
5616:
5615:
5612:
5609:
5606:
5605:
5603:
5601:
5597:
5591:
5588:
5585:
5584:
5581:
5578:
5575:
5574:
5572:
5570:
5566:
5560:
5557:
5554:
5553:
5550:
5547:
5545:
5542:
5539:
5538:
5536:
5534:
5530:
5527:
5525:
5521:
5515:
5512:
5510:
5507:
5505:
5502:
5499:
5498:
5495:
5492:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5450:
5447:
5445:
5442:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5414:
5413:
5409:
5405:
5401:
5397:
5393:
5390:
5388:
5385:
5382:
5381:
5379:
5377:
5373:
5367:
5364:
5361:
5360:
5357:
5354:
5351:
5348:
5347:
5344:
5341:
5339:
5336:
5334:
5331:
5329:
5326:
5324:
5321:
5319:
5316:
5314:
5311:
5309:
5306:
5303:
5300:
5299:
5296:
5293:
5291:
5288:
5286:
5285:Dexamethasone
5283:
5281:
5278:
5275:
5274:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5236:
5233:
5231:
5228:
5225:
5224:
5222:
5220:
5216:
5206:
5203:
5201:
5198:
5195:
5194:
5190:
5186:
5182:
5178:
5174:
5170:
5166:
5162:
5159:
5156:
5155:
5153:
5149:
5142:
5139:
5137:
5134:
5131:
5130:
5127:
5123:
5120:
5119:
5117:
5115:
5111:
5104:
5101:
5099:
5096:
5094:
5091:
5089:
5086:
5084:
5081:
5079:
5076:
5074:
5071:
5069:
5066:
5064:
5061:
5058:
5057:
5054:
5051:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5028:
5027:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4993:des(1-3)IGF-1
4990:
4987:
4986:
4984:
4982:
4978:
4975:
4973:
4969:
4963:
4960:
4958:
4957:Telisotuzumab
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4927:
4926:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4822:
4821:
4818:
4815:
4814:Potentiators:
4812:
4811:
4808:
4805:
4803:
4799:
4796:
4795:
4793:
4791:
4787:
4777:
4774:
4771:
4770:
4768:
4764:
4758:
4755:
4752:
4748:
4744:
4740:
4736:
4732:
4728:
4724:
4721:
4719:
4716:
4713:
4712:
4710:
4708:
4704:
4697:
4694:
4691:
4690:
4687:
4684:
4682:
4679:
4677:
4676:Selpercatinib
4674:
4671:
4667:
4663:
4659:
4655:
4651:
4647:
4643:
4640:
4638:
4635:
4632:
4631:
4629:
4627:
4623:
4617:
4614:
4611:
4610:
4607:
4604:
4602:
4599:
4596:
4595:
4592:
4589:
4587:
4584:
4582:
4581:Selpercatinib
4579:
4577:
4574:
4572:
4569:
4566:
4562:
4558:
4554:
4550:
4546:
4542:
4538:
4534:
4530:
4526:
4522:
4518:
4514:
4510:
4507:
4505:
4502:
4499:
4498:
4496:
4494:
4490:
4484:
4481:
4479:
4476:
4474:
4473:Selpercatinib
4471:
4469:
4466:
4463:
4459:
4455:
4451:
4447:
4443:
4439:
4435:
4431:
4427:
4424:
4422:
4419:
4416:
4415:
4413:
4411:
4407:
4404:
4402:
4398:
4387:
4383:
4379:
4375:
4371:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4346:
4345:
4343:
4341:
4337:
4331:
4328:
4326:
4323:
4321:
4318:
4315:
4314:
4310:
4306:
4302:
4298:
4295:
4292:
4291:
4289:
4287:
4283:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4251:
4250:
4247:
4244:
4242:
4239:
4237:
4234:
4232:
4229:
4227:
4224:
4222:
4219:
4216:
4215:
4212:
4208:
4205:
4204:
4202:
4200:
4196:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4149:Depatuxizumab
4147:
4145:
4142:
4139:
4138:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4064:
4063:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4016:
4013:
4012:
4010:
4008:
4000:
3997:
3995:
3991:
3985:
3982:
3980:
3977:
3975:
3972:
3969:
3968:
3966:
3964:
3960:
3953:
3950:
3947:
3944:
3941:
3940:
3937:
3934:
3932:
3929:
3927:
3924:
3921:
3920:
3917:
3914:
3912:
3909:
3906:
3905:
3902:
3899:
3897:
3894:
3891:
3890:
3888:
3886:
3882:
3878:
3875:
3868:
3863:
3861:
3856:
3854:
3849:
3848:
3845:
3838:
3834:
3833:
3829:
3826:
3822:
3821:
3817:
3816:
3812:
3805:
3801:
3796:
3791:
3786:
3781:
3777:
3773:
3769:
3765:
3761:
3756:
3752:
3748:
3744:
3740:
3735:
3730:
3727:(7): 873–83.
3726:
3722:
3718:
3713:
3709:
3705:
3701:
3697:
3692:
3687:
3683:
3679:
3675:
3670:
3666:
3662:
3657:
3652:
3648:
3644:
3640:
3636:
3632:
3627:
3623:
3619:
3614:
3609:
3605:
3601:
3597:
3592:
3588:
3584:
3580:
3576:
3575:Haematologica
3571:
3567:
3563:
3558:
3553:
3548:
3543:
3539:
3535:
3531:
3527:
3523:
3518:
3514:
3510:
3506:
3502:
3498:
3494:
3490:
3486:
3481:
3477:
3473:
3469:
3465:
3461:
3457:
3453:
3449:
3443:
3439:
3435:
3430:
3425:
3421:
3417:
3413:
3408:
3407:
3402:
3394:
3390:
3386:
3382:
3378:
3374:
3366:
3363:
3358:
3354:
3349:
3344:
3340:
3336:
3333:(6): 766–76.
3332:
3328:
3324:
3317:
3314:
3308:
3303:
3299:
3295:
3291:
3284:
3281:
3276:
3272:
3267:
3262:
3258:
3254:
3250:
3246:
3242:
3235:
3232:
3227:
3223:
3219:
3215:
3211:
3207:
3199:
3196:
3191:
3185:
3177:
3173:
3168:
3163:
3158:
3153:
3149:
3145:
3141:
3134:
3131:
3126:
3122:
3117:
3112:
3107:
3102:
3098:
3094:
3090:
3086:
3082:
3075:
3072:
3067:
3063:
3059:
3055:
3051:
3047:
3044:(2): 255–62.
3043:
3039:
3032:
3029:
3024:
3020:
3016:
3012:
3009:(1): 129–35.
3008:
3004:
2997:
2994:
2988:
2985:
2980:
2976:
2971:
2966:
2962:
2958:
2954:
2947:
2944:
2939:
2935:
2931:
2927:
2923:
2919:
2912:
2909:
2904:
2900:
2895:
2890:
2885:
2880:
2876:
2872:
2868:
2861:
2858:
2853:
2849:
2845:
2841:
2837:
2833:
2829:
2825:
2821:
2817:
2810:
2807:
2802:
2798:
2793:
2788:
2784:
2780:
2776:
2772:
2768:
2764:
2760:
2753:
2750:
2745:
2741:
2737:
2733:
2729:
2725:
2718:
2715:
2710:
2706:
2702:
2698:
2694:
2690:
2683:
2680:
2675:
2671:
2667:
2663:
2659:
2655:
2651:
2647:
2640:
2637:
2632:
2625:
2622:
2617:
2613:
2609:
2605:
2601:
2597:
2593:
2589:
2585:
2581:
2574:
2571:
2566:
2562:
2557:
2552:
2548:
2544:
2540:
2533:
2530:
2525:
2521:
2517:
2513:
2510:(5): 375–84.
2509:
2505:
2498:
2496:
2492:
2487:
2483:
2479:
2475:
2471:
2467:
2463:
2459:
2452:
2449:
2444:
2440:
2436:
2432:
2425:
2422:
2417:
2413:
2408:
2403:
2399:
2395:
2391:
2387:
2383:
2376:
2373:
2368:
2364:
2359:
2354:
2350:
2346:
2342:
2335:
2333:
2329:
2324:
2320:
2315:
2310:
2305:
2300:
2296:
2292:
2288:
2286:
2277:
2274:
2269:
2265:
2260:
2255:
2251:
2247:
2243:
2239:
2235:
2231:
2227:
2220:
2217:
2212:
2208:
2203:
2198:
2194:
2190:
2186:
2179:
2177:
2173:
2168:
2164:
2159:
2154:
2149:
2144:
2140:
2136:
2132:
2125:
2123:
2121:
2117:
2112:
2108:
2104:
2100:
2097:(3): 149–57.
2096:
2092:
2084:
2081:
2076:
2072:
2067:
2062:
2058:
2054:
2050:
2043:
2040:
2035:
2031:
2027:
2023:
2020:(4): 245–55.
2019:
2015:
2008:
2005:
2000:
1996:
1991:
1986:
1982:
1978:
1974:
1970:
1966:
1962:
1958:
1951:
1949:
1947:
1943:
1938:
1934:
1929:
1924:
1920:
1916:
1913:(3): 622–31.
1912:
1908:
1904:
1897:
1894:
1889:
1885:
1880:
1875:
1870:
1865:
1861:
1857:
1853:
1846:
1844:
1840:
1834:
1830:
1826:
1822:
1818:
1814:
1811:(4): 215–21.
1810:
1806:
1799:
1796:
1791:
1787:
1783:
1779:
1775:
1771:
1767:
1763:
1756:
1753:
1747:
1743:
1739:
1735:
1731:
1727:
1723:
1719:
1712:
1709:
1704:
1700:
1696:
1692:
1688:
1684:
1677:
1674:
1669:
1665:
1661:
1657:
1653:
1649:
1646:(2): 132–41.
1645:
1641:
1634:
1631:
1626:
1622:
1618:
1616:0-444-81680-1
1612:
1608:
1601:
1598:
1593:
1589:
1585:
1581:
1574:
1571:
1566:
1562:
1558:
1554:
1551:(1): 144–52.
1550:
1546:
1539:
1536:
1531:
1525:
1523:
1521:
1519:
1515:
1510:
1506:
1502:
1498:
1495:(3): 535–41.
1494:
1490:
1482:
1479:
1474:
1470:
1466:
1462:
1458:
1457:10.1038/15496
1454:
1451:(3): 319–22.
1450:
1446:
1438:
1436:
1432:
1427:
1423:
1417:
1414:
1409:
1405:
1399:
1396:
1392:
1388:
1383:
1381:
1379:
1375:
1371:
1367:
1362:
1360:
1358:
1354:
1348:
1346:
1344:
1340:
1336:
1332:
1327:
1325:
1321:
1316:
1312:
1307:
1304:
1300:
1299:tendon grafts
1296:
1292:
1287:
1284:
1279:
1277:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1249:camptodactyly
1246:
1242:
1234:
1232:
1228:
1224:
1216:
1212:
1208:
1206:
1201:
1199:
1195:
1191:
1187:
1182:
1178:
1174:
1172:
1167:
1163:
1158:
1156:
1154:
1149:
1145:
1141:
1137:
1133:
1132:somatomedin B
1129:
1125:
1117:
1115:
1111:
1109:
1108:cell adhesion
1105:
1095:
1091:
1089:
1085:
1081:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1048:
1047:megakaryocyte
1045:
1041:
1037:
1033:
1029:
1021:
1019:
1017:
1013:
1009:
1006:
1002:
998:
994:
982:
977:
973:
969:
966:
962:
955:
953:
950:
946:
942:
938:
935:
931:
927:
920:
918:
914:
908:
904:
901:
895:
893:
889:
885:
881:
877:
871:
867:
864:
860:
853:
851:
847:
841:
837:
834:
828:
826:
822:
818:
814:
810:
804:
800:
797:
795:RefSeq (mRNA)
793:
786:
785:
780:
776:
773:
767:
766:
761:
757:
754:
752:
748:
741:
740:
735:
731:
728:
722:
721:
716:
712:
709:
707:
703:
696:
695:
690:
686:
683:
677:
676:
671:
667:
664:
662:
658:
655:
652:
650:
647:
643:
640:
636:
632:
625:
621:
616:
610:
607:
605:
602:
600:
597:
595:
592:
590:
587:
586:
584:
581:
580:
574:
571:
569:
566:
564:
561:
560:
558:
555:
554:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
6775:Cerebrolysin
6771:
6745:Pleiotrophin
6701:Interleukins
6614:
6595:
6565:
6484:Fruquintinib
6474:Cabozantinib
6455:
6445:
6403:
6367:Lestaurtinib
6318:
6298:
6266:Lestaurtinib
6217:
6207:
6188:Antagonists:
6187:
6121:Deoxygedunin
6076:3,7,8,2'-THF
6067:
6046:
6037:Against NGF:
6036:
6033:
5989:Against NGF:
5988:
5981:
5978:
5941:Lestaurtinib
5892:
5882:
5876:Testosterone
5858:Antagonists:
5857:
5807:
5707:
5692:
5667:
5648:
5638:
5617:
5607:
5586:
5576:
5555:
5540:
5500:
5415:
5383:
5362:
5353:Against NGF:
5352:
5349:
5305:Against NGF:
5304:
5301:
5295:Testosterone
5277:Antagonists:
5276:
5226:
5196:
5157:
5132:
5121:
5098:Teprotumumab
5059:
5029:
4988:
4937:Ficlatuzumab
4932:Emibetuzumab
4928:
4882:JNJ-38877605
4852:Cabozantinib
4823:
4813:
4802:Fosgonimeton
4797:
4772:
4714:
4692:
4633:
4616:Infigratinib
4612:
4597:
4500:
4417:
4351:Betacellulin
4347:
4330:Seribantumab
4316:
4293:
4252:
4217:
4211:Unknown/none
4210:
4206:
4140:
4065:
4024:Betacellulin
4019:Amphiregulin
4014:
4006:(ErbB1/HER1)
3970:
3942:
3922:
3908:Antagonists:
3907:
3892:
3885:Angiopoietin
3831:
3819:
3767:
3763:
3724:
3720:
3681:
3677:
3638:
3634:
3603:
3599:
3578:
3574:
3529:
3525:
3488:
3484:
3454:(1): 57–66.
3451:
3447:
3422:(4): 730–5.
3419:
3415:
3379:(1): 77–87.
3376:
3372:
3365:
3330:
3326:
3316:
3297:
3293:
3283:
3248:
3244:
3234:
3209:
3205:
3198:
3184:cite journal
3147:
3143:
3133:
3088:
3084:
3074:
3041:
3037:
3031:
3006:
3002:
2996:
2987:
2960:
2956:
2946:
2921:
2917:
2911:
2874:
2870:
2860:
2819:
2815:
2809:
2769:(1): 13149.
2766:
2762:
2752:
2727:
2723:
2717:
2692:
2688:
2682:
2649:
2645:
2639:
2624:
2583:
2579:
2573:
2546:
2542:
2532:
2507:
2503:
2461:
2457:
2451:
2434:
2430:
2424:
2389:
2385:
2375:
2348:
2344:
2294:
2290:
2284:
2276:
2233:
2229:
2219:
2192:
2188:
2138:
2134:
2094:
2090:
2083:
2056:
2052:
2042:
2017:
2013:
2007:
1964:
1960:
1910:
1906:
1896:
1859:
1855:
1808:
1804:
1798:
1765:
1761:
1755:
1724:(3): 562–8.
1721:
1717:
1711:
1686:
1682:
1676:
1643:
1639:
1633:
1606:
1600:
1583:
1579:
1573:
1548:
1544:
1538:
1492:
1488:
1481:
1448:
1444:
1425:
1416:
1407:
1398:
1328:
1308:
1288:
1280:
1261:pericarditis
1238:
1229:
1225:
1221:
1209:
1202:
1186:mucin domain
1170:
1162:glycoprotein
1159:
1152:
1147:
1124:chondrocytes
1121:
1112:
1101:
1025:
1004:
1001:proteoglycan
996:
992:
991:
913:NP_001103616
910:
888:NP_001290161
884:NP_001121182
880:NP_001121181
876:NP_001121180
873:
846:NM_001110146
843:
825:NM_001303232
821:NM_001127710
817:NM_001127709
813:NM_001127708
806:
782:
763:
737:
718:
692:
673:
653:
648:
447:aortic valve
335:
328:
294:150,466,165
281:150,449,412
193:186,314,567
180:186,296,279
55:External IDs
18:
6735:Oncomodulin
6599:Aflibercept
6589:Ranibizumab
6584:Ramucirumab
6574:Bevacizumab
6566:Antibodies:
6524:Regorafenib
6464:Altiratinib
6377:ONO-5390556
6347:Entrectinib
6322:Altiratinib
6276:ONO-5390556
6246:Entrectinib
6221:Altiratinib
6007:Frunevetmab
5979:Antibodies:
5956:ONO-5390556
5921:Entrectinib
5896:Altiratinib
5851:Tavilermide
5746:Quizartinib
5685:SCF (c-Kit)
5509:Ramucirumab
5501:Antibodies:
5474:Quizartinib
5424:Avapritinib
5387:Becaplermin
5323:Frunevetmab
5302:Antibodies:
5205:Trofinetide
5136:Dusigitumab
5133:Antibodies:
5088:Robatumumab
5078:Figitumumab
5073:Dalotuzumab
5068:Cixutumumab
5060:Antibodies:
4952:Rilotumumab
4947:Onartuzumab
4942:Flanvotumab
4929:Antibodies:
4897:PF-04217903
4827:Altiratinib
4790:HGF (c-Met)
4693:Antibodies:
4598:Antibodies:
4320:Duligotumab
4317:Antibodies:
4231:Trastuzumab
4221:Ertumaxomab
4218:Antibodies:
4189:Zalutumumab
4184:Panitumumab
4179:Nimotuzumab
4174:Necitumumab
4164:Imgatuzumab
4141:Antibodies:
4124:Osimertinib
4089:Dacomitinib
3984:Dapiclermin
3943:Antibodies:
3926:Altiratinib
2631:"Biorender"
2392:: 200–206.
1339:recombinant
1335:conjunctiva
1253:arthropathy
1205:vitronectin
1177:sialic acid
1040:homeostasis
1018:lubricant.
609:endocytosis
369:pericardium
273:1|1 G1
33:Identifiers
6791:Categories
6554:Vandetanib
6519:Rebastinib
6514:Pegaptanib
6504:Nintedanib
6494:Lenvatinib
6459:Agerafenib
6412:Ripretinib
6337:CH-7057288
6236:CH-7057288
6101:7,8,3'-THF
6096:7,8,2'-THF
6022:Ranevetmab
6012:Fulranumab
5966:Rebastinib
5911:CH-7057288
5826:Cenegermin
5711:Agerafenib
5671:Agerafenib
5652:Vandetanib
5621:Vandetanib
5590:Vandetanib
5559:Vandetanib
5504:Olaratumab
5479:Ripretinib
5459:Nintedanib
5444:Lenvatinib
5434:Crenolanib
5419:Agerafenib
5338:Ranevetmab
5328:Fulranumab
5245:Cenegermin
5219:LNGF (p75)
5141:Xentuzumab
5103:Xentuzumab
5048:NVP-AEW541
5043:NVP-ADW742
5038:Linsitinib
5033:BMS-754807
5018:Mecasermin
4917:Tivantinib
4907:PHA-665752
4902:PF-2341066
4872:Golvatinib
4862:Crizotinib
4857:Capmatinib
4847:BMS-777607
4842:Amuvatinib
4718:Ersofermin
4681:Sprifermin
4637:Ersofermin
4586:Sprifermin
4576:Repifermin
4571:Palifermin
4504:Ersofermin
4483:Velafermin
4468:Repifermin
4421:Ersofermin
4340:ErbB4/HER4
4325:Patritumab
4286:ErbB3/HER3
4266:Mubritinib
4226:Pertuzumab
4199:ErbB2/HER2
4129:Vandetanib
4084:Canertinib
4079:Brigatinib
4074:Agerafenib
4054:Nepidermin
4049:Murodermin
4039:Epiregulin
3994:EGF (ErbB)
3952:Nesvacumab
3946:Evinacumab
3936:Rebastinib
3877:modulators
3684:(2): 213.
3581:(2): 152.
3371:Disease".
3150:(1): 353.
1393:, May 2017
1372:, May 2017
1349:References
1295:cd-gelatin
1263:syndrome (
1194:Galectin-3
1088:L-selectin
339:(ortholog)
76:HomoloGene
6579:Icrucumab
6559:WHI-P 154
6549:Tivozanib
6544:Toceranib
6539:Sunitinib
6534:Sorafenib
6529:Semaxanib
6509:Pazopanib
6499:Motesanib
6489:Lapatinib
6479:Cediranib
6417:Telbermin
6404:Agonists:
6352:GZ-389988
6332:CE-245677
6299:Agonists:
6251:GZ-389988
6231:CE-245677
6131:Diosmetin
6068:Agonists:
6034:Aptamers:
6027:Tanezumab
6002:Fasinumab
5946:Milciclib
5926:GZ-389988
5906:CE-245677
5808:Agonists:
5761:Toceranib
5756:Sunitinib
5751:Sorafenib
5741:Pazopanib
5736:Nilotinib
5731:Masitinib
5721:Dasatinib
5693:Agonists:
5639:Agonists:
5608:Agonists:
5577:Agonists:
5549:Liatermin
5541:Agonists:
5524:RET (GFL)
5514:Tovetumab
5494:Toceranib
5489:Sorafenib
5484:Sunitinib
5469:Radotinib
5464:Pazopanib
5454:Motesanib
5449:Masitinib
5384:Agonists:
5350:Aptamers:
5343:Tanezumab
5318:Fasinumab
5227:Agonists:
5083:Ganitumab
5003:IGF-1 LR3
4922:Volitinib
4877:INCB28060
4867:Foretinib
4773:Agonists:
4757:Trafermin
4715:Agonists:
4696:Burosumab
4686:Trafermin
4634:Agonists:
4601:Aprutumab
4591:Trafermin
4553:10 (KGF2)
4501:Agonists:
4478:Trafermin
4458:10 (KGF2)
4418:Agonists:
4348:Agonists:
4294:Agonists:
4276:Tucatinib
4271:Neratinib
4261:Lapatinib
4169:Matuzumab
4159:Futuximab
4144:Cetuximab
4134:WHI-P 154
4119:Neratinib
4114:Lapatinib
4104:Grandinin
4099:Gefitinib
4094:Erlotinib
3971:Agonists:
3931:CE-245677
3893:Agonists:
2674:206510494
2236:: 25463.
2091:Hybridoma
2059:: 17–24.
1625:246493326
1324:synovitis
1273:autosomal
1269:arthritis
1257:coxa vara
1200:ability.
1144:hemopexin
1118:Structure
1032:cartilage
917:NP_067375
892:NP_005798
850:NM_021400
809:NM_005807
639:Orthologs
84:GeneCards
6761:instead)
6750:Renalase
6711:instead)
6682:instead)
6629:instead)
6469:Axitinib
6438:D (FIGF)
6382:PLX-7486
6372:ONO-4474
6327:AZD-6918
6281:PLX-7486
6271:ONO-4474
6226:AZD-6918
6208:Ligands:
6126:Deprenyl
6086:7,3'-DHF
6017:MEDI-578
5997:ASP-6294
5961:PLX-7486
5951:ONO-4474
5901:AZD-6918
5861:ALE-0540
5782:instead.
5726:Imatinib
5716:Axitinib
5696:Ancestim
5661:Unsorted
5439:Imatinib
5429:Axitinib
5333:MEDI-578
5313:ASP-6294
5280:ALE-0540
5122:Agonists
5063:AVE-1642
4989:Agonists
4912:SU-11274
4798:Agonists
4776:FGF15/19
4766:Unsorted
4731:2 (bFGF)
4650:2 (bFGF)
4517:2 (bFGF)
4434:2 (bFGF)
4256:Afatinib
4207:Agonists
4109:Icotinib
4069:Afatinib
4015:Agonists
3804:17404241
3743:17343281
3708:21403617
3700:16429407
3665:16335952
3622:16000300
3587:15710563
3566:15302935
3505:14976050
3476:22232515
3468:12783322
3393:27614318
3357:23599181
3275:18512776
3226:22933061
3176:26643105
3125:25933137
3085:PLOS ONE
3066:12089961
3058:22009294
3023:18171967
2979:23046176
2957:Langmuir
2938:24716507
2903:29568558
2844:17093447
2801:29030641
2744:18067335
2724:Langmuir
2666:18239111
2565:16000300
2524:19332105
2486:23192748
2478:12441670
2416:28208081
2367:28373131
2323:32928962
2268:27157803
2167:25187573
2111:11461663
2075:25172828
1999:17142292
1937:15719068
1888:22930755
1833:46582604
1825:16987753
1790:39376563
1782:11124536
1738:15885476
1703:12475643
1660:21966936
1592:10743795
1473:32556762
1465:10545950
1389:–
1368:–
1076:ligament
1056:meniscus
1044:in-vitro
1022:Function
1016:boundary
997:lubricin
965:Wikidata
618:Sources:
6638:Ephrins
6342:DS-6051
6241:DS-6051
6146:LM22A-4
6136:DMAQ-B1
6091:7,8-DHF
6071:3,7-DHF
6040:RBM-004
5985:GBR-900
5916:DS-6051
5886:VM-902A
5356:RBM-004
5053:OSl-906
5013:Insulin
4892:MK-2461
4837:AMG-458
3974:Axokine
3795:1851076
3772:Bibcode
3751:6804891
3656:1850943
3534:Bibcode
3513:2103324
3438:9550484
3348:3887468
3300:: S32.
3266:2789974
3167:4672561
3116:4416892
3093:Bibcode
2894:5857089
2852:4325718
2824:Bibcode
2792:5640667
2771:Bibcode
2697:Bibcode
2646:Science
2616:1832467
2608:5473985
2588:Bibcode
2394:Bibcode
2314:7681006
2259:4860590
2238:Bibcode
2211:7240180
2158:4256492
2034:1304440
1990:1796837
1969:Bibcode
1879:3476260
1746:1011398
1668:7344867
1565:8185311
1509:9920774
1391:Ensembl
1370:Ensembl
1343:dry eye
1173:-linked
1166:protein
1136:heparin
751:UniProt
706:Ensembl
645:Species
624:QuickGO
431:trachea
314:pattern
72:1891344
40:Aliases
6608:Others
6302:BNN-20
6191:ANA-12
6116:BNN-20
5836:DHEA-S
5821:BNN-27
5816:BNN-20
5255:DHEA-S
5240:BNN-27
5235:BNN-20
5151:Others
4356:Epigen
4034:Epigen
3802:
3792:
3749:
3741:
3706:
3698:
3663:
3653:
3620:
3585:
3564:
3557:514446
3554:
3511:
3503:
3474:
3466:
3436:
3391:
3355:
3345:
3273:
3263:
3224:
3174:
3164:
3123:
3113:
3064:
3056:
3021:
2977:
2936:
2901:
2891:
2850:
2842:
2816:Nature
2799:
2789:
2742:
2672:
2664:
2614:
2606:
2580:Nature
2563:
2522:
2484:
2476:
2414:
2365:
2321:
2311:
2266:
2256:
2209:
2165:
2155:
2109:
2073:
2032:
1997:
1987:
1935:
1928:548698
1925:
1886:
1876:
1831:
1823:
1788:
1780:
1744:
1736:
1701:
1666:
1658:
1623:
1613:
1590:
1563:
1507:
1471:
1463:
1331:cornea
1271:-like
1267:), an
1082:, and
1080:muscle
1052:tendon
951:search
949:PubMed
784:Q9JM99
765:Q92954
661:Entrez
485:BioGPS
172:1q31.1
80:130465
64:604283
6757:(see
6707:(see
6678:(see
6625:(see
6357:K252a
6256:K252a
5931:K252a
5871:FX007
5631:GFRα4
5600:GFRα3
5569:GFRα2
5533:GFRα1
5161:IGFBP
5114:IGF-2
5093:R1507
4981:IGF-1
4887:K252a
4707:FGFR4
4626:FGFR3
4493:FGFR2
4410:FGFR1
3747:S2CID
3704:S2CID
3509:S2CID
3485:Blood
3472:S2CID
3062:S2CID
2877:: 9.
2848:S2CID
2670:S2CID
2612:S2CID
2482:S2CID
1829:S2CID
1786:S2CID
1742:S2CID
1664:S2CID
1469:S2CID
1283:locus
1140:mucin
1104:mucin
1068:heart
1064:liver
1036:joint
1012:joint
999:is a
694:96875
675:10216
654:Mouse
649:Human
620:Amigo
423:ankle
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
6759:here
6709:here
6680:here
6627:here
6422:VEGF
6396:VEGF
6312:NT-3
6307:DHEA
6291:TrkC
6211:DHEA
6181:TDP6
6161:NT-4
6156:NT-3
6141:HIOC
6111:BDNF
6060:TrkB
5831:DHEA
5800:TrkA
5780:here
5778:See
5771:TGFβ
5376:PDGF
5270:NT-4
5265:NT-3
5250:DHEA
5230:BDNF
3979:CNTF
3963:CNTF
3832:PRG4
3820:PRG4
3800:PMID
3739:PMID
3696:PMID
3661:PMID
3618:PMID
3583:PMID
3562:PMID
3501:PMID
3464:PMID
3434:PMID
3389:PMID
3353:PMID
3271:PMID
3222:PMID
3190:link
3172:PMID
3121:PMID
3054:PMID
3019:PMID
2975:PMID
2934:PMID
2899:PMID
2840:PMID
2797:PMID
2740:PMID
2662:PMID
2604:PMID
2561:PMID
2520:PMID
2508:1790
2474:PMID
2412:PMID
2363:PMID
2319:PMID
2264:PMID
2207:PMID
2163:PMID
2107:PMID
2071:PMID
2030:PMID
1995:PMID
1933:PMID
1884:PMID
1821:PMID
1778:PMID
1734:PMID
1699:PMID
1656:PMID
1621:OCLC
1611:ISBN
1588:PMID
1561:PMID
1505:PMID
1461:PMID
1333:and
1313:and
1281:The
1265:CACP
1084:skin
1072:bone
1060:lung
1008:gene
1005:PRG4
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
88:PRG4
60:OMIM
47:PRG4
24:PRG4
6176:R13
5846:NGF
5791:Trk
5260:NGF
4972:IGF
4832:AM7
4723:FGF
4642:FGF
4543:),
4541:KGF
4509:FGF
4426:FGF
4401:FGF
4003:EGF
3790:PMC
3780:doi
3768:104
3729:doi
3686:doi
3651:PMC
3643:doi
3608:doi
3604:280
3552:PMC
3542:doi
3530:101
3493:doi
3489:103
3456:doi
3452:443
3424:doi
3381:doi
3343:PMC
3335:doi
3331:131
3302:doi
3261:PMC
3253:doi
3214:doi
3162:PMC
3152:doi
3111:PMC
3101:doi
3046:doi
3042:346
3011:doi
2965:doi
2926:doi
2922:136
2889:PMC
2879:doi
2832:doi
2820:444
2787:PMC
2779:doi
2732:doi
2705:doi
2654:doi
2650:319
2596:doi
2584:228
2551:doi
2547:280
2512:doi
2466:doi
2439:doi
2402:doi
2390:495
2353:doi
2309:PMC
2299:doi
2295:295
2254:PMC
2246:doi
2197:doi
2193:256
2153:PMC
2143:doi
2099:doi
2061:doi
2022:doi
1985:PMC
1977:doi
1923:PMC
1915:doi
1911:115
1874:PMC
1864:doi
1860:287
1813:doi
1770:doi
1726:doi
1691:doi
1648:doi
1553:doi
1549:311
1497:doi
1493:254
1453:doi
1320:ACL
995:or
290:End
189:End
92:OMA
68:MGI
6793::
6670:B3
6668:,
6666:B2
6664:,
6662:B1
6660:,
6658:A5
6656:,
6654:A4
6652:,
6650:A3
6648:,
6646:A2
6644:,
6642:A1
6436:,
6432:,
6428:,
6171:R7
5987:;
5406:,
5402:,
5398:,
5187:,
5183:,
5179:,
5175:,
5171:,
5167:,
5124::
4991::
4800::
4751:19
4749:,
4745:,
4741:,
4737:,
4733:,
4729:,
4670:23
4668:,
4666:18
4664:,
4660:,
4656:,
4652:,
4648:,
4565:22
4563:,
4561:18
4559:,
4557:17
4555:,
4551:,
4547:,
4535:,
4531:,
4527:,
4523:,
4519:,
4515:,
4462:20
4460:,
4456:,
4452:,
4448:,
4444:,
4440:,
4436:,
4432:,
4384:,
4380:,
4376:,
4372:,
4307:,
4303:,
4209::
4017::
3798:.
3788:.
3778:.
3766:.
3762:.
3745:.
3737:.
3725:25
3723:.
3719:.
3702:.
3694:.
3682:27
3680:.
3676:.
3659:.
3649:.
3637:.
3633:.
3616:.
3602:.
3598:.
3579:90
3577:.
3560:.
3550:.
3540:.
3528:.
3524:.
3507:.
3499:.
3487:.
3470:.
3462:.
3450:.
3432:.
3420:41
3418:.
3414:.
3387:.
3377:15
3375:.
3351:.
3341:.
3329:.
3325:.
3296:.
3292:.
3269:.
3259:.
3249:58
3247:.
3243:.
3220:.
3210:64
3208:.
3186:}}
3182:{{
3170:.
3148:17
3146:.
3142:.
3119:.
3109:.
3099:.
3089:10
3087:.
3083:.
3060:.
3052:.
3040:.
3017:.
3007:90
3005:.
2973:.
2961:28
2959:.
2955:.
2932:.
2920:.
2897:.
2887:.
2875:22
2873:.
2869:.
2846:.
2838:.
2830:.
2818:.
2795:.
2785:.
2777:.
2765:.
2761:.
2738:.
2728:24
2726:.
2703:.
2693:13
2691:.
2668:.
2660:.
2648:.
2610:.
2602:.
2594:.
2582:.
2559:.
2545:.
2541:.
2518:.
2506:.
2494:^
2480:.
2472:.
2462:18
2460:.
2435:15
2433:.
2410:.
2400:.
2388:.
2384:.
2361:.
2349:25
2347:.
2343:.
2331:^
2317:.
2307:.
2293:.
2289:.
2285:O-
2262:.
2252:.
2244:.
2232:.
2228:.
2205:.
2191:.
2187:.
2175:^
2161:.
2151:.
2139:13
2137:.
2133:.
2119:^
2105:.
2095:20
2093:.
2069:.
2057:39
2055:.
2051:.
2028:.
2018:28
2016:.
1993:.
1983:.
1975:.
1965:92
1963:.
1959:.
1945:^
1931:.
1921:.
1909:.
1905:.
1882:.
1872:.
1858:.
1854:.
1842:^
1827:.
1819:.
1809:47
1807:.
1784:.
1776:.
1766:90
1764:.
1740:.
1732:.
1722:23
1720:.
1697:.
1687:21
1685:.
1662:.
1654:.
1644:53
1642:.
1619:.
1584:27
1582:.
1559:.
1547:.
1517:^
1503:.
1491:.
1467:.
1459:.
1449:23
1447:.
1434:^
1424:.
1406:.
1377:^
1356:^
1326:.
1278:.
1179:.
1157:.
1090:.
1078:,
1074:,
1070:,
1066:,
1062:,
1058:,
1054:,
622:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
6703:/
6672:)
6640:(
6440:)
6434:C
6430:B
6426:A
6424:(
5973:)
5410:)
5408:D
5404:C
5400:B
5396:A
5394:(
5191:)
5189:7
5185:6
5181:5
5177:4
5173:3
5169:2
5165:1
5163:(
4753:)
4747:9
4743:8
4739:6
4735:4
4727:1
4725:(
4672:)
4662:9
4658:8
4654:4
4646:1
4644:(
4567:)
4549:9
4545:8
4539:(
4537:7
4533:6
4529:5
4525:4
4521:3
4513:1
4511:(
4464:)
4454:8
4450:6
4446:5
4442:4
4438:3
4430:1
4428:(
4388:)
4382:4
4378:3
4374:2
4370:1
4368:(
4311:)
4305:2
4301:1
4299:(
3866:e
3859:t
3852:v
3839:.
3827:.
3806:.
3782::
3774::
3753:.
3731::
3710:.
3688::
3667:.
3645::
3639:4
3624:.
3610::
3589:.
3568:.
3544::
3536::
3515:.
3495::
3478:.
3458::
3440:.
3426::
3395:.
3383::
3359:.
3337::
3310:.
3304::
3298:9
3277:.
3255::
3228:.
3216::
3192:)
3178:.
3154::
3127:.
3103::
3095::
3068:.
3048::
3025:.
3013::
2981:.
2967::
2940:.
2928::
2905:.
2881::
2854:.
2834::
2826::
2803:.
2781::
2773::
2767:7
2746:.
2734::
2711:.
2707::
2699::
2676:.
2656::
2633:.
2618:.
2598::
2590::
2567:.
2553::
2526:.
2514::
2488:.
2468::
2445:.
2441::
2418:.
2404::
2396::
2369:.
2355::
2325:.
2301::
2270:.
2248::
2240::
2234:6
2213:.
2199::
2169:.
2145::
2113:.
2101::
2077:.
2063::
2036:.
2024::
2001:.
1979::
1971::
1939:.
1917::
1890:.
1866::
1837:.
1835:.
1815::
1792:.
1772::
1750:.
1748:.
1728::
1705:.
1693::
1670:.
1650::
1627:.
1594:.
1567:.
1555::
1532:.
1511:.
1499::
1475:.
1455::
1428:.
1410:.
1259:-
1255:-
1251:-
1171:O
1153:O
1148:N
1014:/
214:)
111:)
94::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
