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Granulation tissue

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and microscopic blood vessels that form on the surfaces of a wound during the healing process. Granulation tissue typically grows from the base of a wound and is able to fill wounds of almost any size. Examples of granulation tissue can be seen in
449:, and protect the healing tissue from pathogenic infection. This is necessary both to aid the healing process and to protect against invading pathogens, as the wound often does not have an effective skin barrier to act as a first line of defense. 523:
It is necessary for a network of blood vessels to be established as soon as possible to provide the growing tissue with nutrients, to take away cellular wastes, and transport new leukocytes to the area.
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Granulation tissue is composed of tissue matrix supporting a variety of cell types, most of which can be associated with one of the following functions:
693: 331: 781: 484: 390: 292: 67: 623: 510: 416: 318: 133: 114: 347:, a weaker form of the structural protein that can be produced rapidly. This is later replaced by the stronger, long-stranded 86: 488: 394: 296: 71: 776: 662: 93: 748: 38: 592: 686: 162:. Its histological appearance is characterized by proliferation of fibroblasts and thin-walled, delicate capillaries ( 473: 379: 281: 638: 100: 492: 477: 398: 383: 300: 285: 60: 82: 335:
Histopathology of granulation tissue at 11 days after injury, showing fibroblasts, hemorrhage and lymphocytes.
679: 528:, the main cells that deposit granulation tissue, depend on oxygen to proliferate and lay down the new 529: 260: 227: 649: 200: 174: 155: 107: 619: 344: 150: 446: 645: 348: 755: 718: 770: 728: 702: 559: 234: 183: 554: 743: 544: 536: 240: 163: 548: 540: 462: 442: 434: 430: 368: 340: 270: 49: 525: 438: 159: 562:, with substantial variation depending on wound size and healing conditions. 738: 584: 207: 31: 17: 339:
The extracellular matrix of granulation tissue is created and modified by
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light red or dark pink, being perfused with new capillary loops or "buds";
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Example of granulation tissue from a cut on a finger with "proud flesh".
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Initially, it consists of a network of 27:New tissue that forms on a wound's surface 511:Learn how and when to remove this message 417:Learn how and when to remove this message 319:Learn how and when to remove this message 134:Learn how and when to remove this message 576: 199:bumpy (granular) in appearance, due to 566:is seen in green box at days to weeks. 595:from the original on 16 November 2018 7: 489:adding citations to reliable sources 395:adding citations to reliable sources 297:adding citations to reliable sources 72:adding citations to reliable sources 25: 441:are also present. These work to 247:An excess of granulation tissue ( 535:In vascularisation, also called 461: 367: 269: 48: 585:"Granulation Tissue Definition" 59:needs additional citations for 182:During the migratory phase of 1: 564:Granulation tissue formation 39:Proud Flesh (disambiguation) 661:Reference list is found on 616:Srb's Manual of Surgery, 4e 798: 782:Connective tissue diseases 258: 36: 29: 709: 186:, granulation tissue is: 30:Not to be confused with 567: 336: 213:painless when healthy; 179: 614:Bhat, Sriram (2013). 557: 334: 177: 777:Anatomical pathology 551:with other vessels. 530:extracellular matrix 485:improve this section 391:improve this section 293:improve this section 261:Extracellular matrix 255:Extracellular matrix 228:extracellular matrix 201:punctate hemorrhages 83:"Granulation tissue" 68:improve this article 650:Tuskegee University 156:pyogenic granulomas 724:Granulation tissue 644:2010-09-27 at the 639:Healing and Repair 568: 351:, as evidenced in 337: 193:soft to the touch; 180: 147:Granulation tissue 764: 763: 541:endothelial cells 521: 520: 513: 437:, although other 427: 426: 419: 345:type-III collagen 329: 328: 321: 233:operation of the 151:connective tissue 144: 143: 136: 118: 16:(Redirected from 789: 696: 689: 682: 673: 666: 659: 653: 636: 630: 629: 611: 605: 604: 602: 600: 581: 516: 509: 505: 502: 496: 465: 457: 422: 415: 411: 408: 402: 371: 363: 324: 317: 313: 310: 304: 273: 265: 139: 132: 128: 125: 119: 117: 76: 52: 44: 21: 797: 796: 792: 791: 790: 788: 787: 786: 767: 766: 765: 760: 749:Intussusception 705: 700: 670: 669: 663:image main page 660: 656: 646:Wayback Machine 637: 633: 626: 613: 612: 608: 598: 596: 583: 582: 578: 573: 517: 506: 500: 497: 482: 466: 455: 453:Vascularization 445:old or damaged 423: 412: 406: 403: 388: 372: 361: 349:type-I collagen 325: 314: 308: 305: 290: 274: 263: 257: 241:vascularisation 220: 172: 140: 129: 123: 120: 77: 75: 65: 53: 42: 35: 28: 23: 22: 15: 12: 11: 5: 795: 793: 785: 784: 779: 769: 768: 762: 761: 759: 758: 756:Vasculogenesis 753: 752: 751: 741: 736: 731: 726: 721: 719:Maggot therapy 716: 710: 707: 706: 701: 699: 698: 691: 684: 676: 668: 667: 654: 631: 624: 606: 575: 574: 572: 569: 519: 518: 469: 467: 460: 454: 451: 425: 424: 375: 373: 366: 360: 357: 327: 326: 277: 275: 268: 259:Main article: 256: 253: 249:caro luxurians 245: 244: 238: 231: 219: 216: 215: 214: 211: 204: 197: 194: 191: 171: 168: 142: 141: 56: 54: 47: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 794: 783: 780: 778: 775: 774: 772: 757: 754: 750: 747: 746: 745: 742: 740: 737: 735: 732: 730: 729:Growth factor 727: 725: 722: 720: 717: 715: 712: 711: 708: 704: 703:Wound healing 697: 692: 690: 685: 683: 678: 677: 674: 664: 658: 655: 651: 647: 643: 640: 635: 632: 627: 625:9789350259443 621: 617: 610: 607: 594: 590: 586: 580: 577: 570: 565: 561: 560:wound healing 556: 552: 550: 546: 545:blood vessels 542: 538: 533: 531: 527: 515: 512: 504: 501:February 2024 494: 490: 486: 480: 479: 475: 470:This section 468: 464: 459: 458: 452: 450: 448: 444: 440: 436: 432: 421: 418: 410: 407:February 2024 400: 396: 392: 386: 385: 381: 376:This section 374: 370: 365: 364: 358: 356: 354: 350: 346: 342: 333: 323: 320: 312: 309:February 2024 302: 298: 294: 288: 287: 283: 278:This section 276: 272: 267: 266: 262: 254: 252: 250: 242: 239: 236: 235:immune system 232: 229: 226:formation of 225: 224: 223: 217: 212: 209: 206:pulsatile on 205: 202: 198: 195: 192: 189: 188: 187: 185: 184:wound healing 176: 169: 167: 165: 161: 157: 152: 148: 138: 135: 127: 116: 113: 109: 106: 102: 99: 95: 92: 88: 85: –  84: 80: 79:Find sources: 73: 69: 63: 62: 57:This article 55: 51: 46: 45: 40: 33: 19: 744:Angiogenesis 723: 657: 634: 615: 609: 597:. Retrieved 588: 579: 563: 537:angiogenesis 534: 522: 507: 498: 483:Please help 471: 428: 413: 404: 389:Please help 377: 338: 315: 306: 291:Please help 279: 248: 246: 221: 181: 164:angiogenesis 146: 145: 130: 121: 111: 104: 97: 90: 78: 66:Please help 61:verification 58: 549:anastomoses 526:Fibroblasts 443:phagocytize 435:neutrophils 431:macrophages 341:fibroblasts 160:pulp polyps 18:Proud flesh 771:Categories 599:25 October 571:References 439:leukocytes 170:Appearance 94:newspapers 739:Stem cell 472:does not 378:does not 280:does not 218:Structure 208:palpation 32:Granuloma 714:Fibrosis 642:Archived 593:Archived 359:Immunity 355:tissue. 124:May 2020 652:website 589:Memidex 493:removed 478:sources 399:removed 384:sources 301:removed 286:sources 149:is new 108:scholar 622:  447:tissue 196:moist; 110:  103:  96:  89:  81:  115:JSTOR 101:books 734:Scar 620:ISBN 601:2014 476:any 474:cite 433:and 382:any 380:cite 353:scar 284:any 282:cite 158:and 87:news 487:by 393:by 295:by 70:by 773:: 591:. 587:. 539:, 532:. 695:e 688:t 681:v 665:. 628:. 603:. 514:) 508:( 503:) 499:( 495:. 481:. 420:) 414:( 409:) 405:( 401:. 387:. 322:) 316:( 311:) 307:( 303:. 289:. 243:; 237:; 230:; 210:; 203:; 137:) 131:( 126:) 122:( 112:· 105:· 98:· 91:· 64:. 41:. 34:. 20:)

Index

Proud flesh
Granuloma
Proud Flesh (disambiguation)

verification
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adding citations to reliable sources
"Granulation tissue"
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scholar
JSTOR
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connective tissue
pyogenic granulomas
pulp polyps
angiogenesis

wound healing
punctate hemorrhages
palpation
extracellular matrix
immune system
vascularisation
Extracellular matrix

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