348:
336:
435:
of
Quinvaxem, or cases for which the information available did not allow for a definite conclusion but there were no clinical signs that were consistent with the use of the vaccine. The WHO report emphasized that more than 400 million doses of Quinvaxem had been administered and that no fatal adverse event had ever been associated with Quinvaxem or similar vaccines.
2788:
2776:
446:
following immunization with pentavalent vaccines, the WHO asked a global panel of independent experts to review the safety of the vaccine. This review took place 12–13 June 2013 and concluded that no unusual reaction could be attributed to pentavalent vaccines. On 20 June 2013, the
Ministry of Health
434:
After a review of the cases conducted by national experts together with staff from WHO and UNICEF and an independent clinician, no link with vaccination could be identified. The fatalities reported in Viet Nam were attributed to coincidental health problems related in time but not related to the use
390:
introduced
Quinvaxem in January 2008. Within three months, four reports of deaths and 24 reports of suspected hypotonic-hyporesponsive episodes prompted regulatory attention and precautionary suspension of the initial vaccine lot. A subsequent death that occurred with the next lot in April 2009 led
418:
shortly after pentavalent vaccination prompted the authorities to suspend vaccination on 23 October 2009. Subsequently, four additional serious cases related to vaccine administered prior to suspension were identified and investigated. After a comprehensive review by independent national and
347:
450:
The reported events in these Asian nations caused public uncertainty regarding the use of pentavalent vaccines to spread to other developing nations. In response to this, and a corresponding spread of inaccurate information about vaccine safety, the
991:
848:
335:
321:
High-income countries tend to use alternative formulations using acellular pertussis (Pa), which has a more favourable profile of side-effects, rather than whole-cell pertussis components. In Europe,
1614:
1162:
812:
431:
of children who had recently received injections of the pentavalent vaccine
Quinvaxem. On 4 May 2013, the Ministry of Health of Viet Nam announced that use of Quinvaxem was suspended.
111:
735:
285:
and other developing nations in separate documents about the use of pentavalent vaccines to protect against five of the leading causes of vaccine-preventable death in children.
1601:
367:
In 2013, it was found that
Pentavac PFS vaccines were being supplied with two different sets of packaging: One set with manufacturing and expiry dates was being provided to
1036:
2679:
251:
to young children who have been given a vaccination course with another pentavalent booster that requires a change in constitution and was also found to be adequately
1194:
856:
1262:
1827:
1472:
1327:
1716:
281:
In 2012, UNICEF and the World Health
Organization issued and recommended a joint statement to the Immunization Division, Ministry of Health and Family Welfare,
1867:
1862:
1010:
1622:
1066:
Obando-Pacheco P, Rivero-Calle I, GĂłmez-Rial J, RodrĂguez-Tenreiro Sánchez C, MartinĂłn-Torres F (August 2018). "New perspectives for hexavalent vaccines".
936:
1629:
2259:
823:
1877:
1294:
2730:
2658:
2264:
1588:
2296:
1979:
1832:
2706:
2048:
2018:
1651:
746:
2118:
1412:
660:
959:
2685:
1660:
399:
vaccination. Following an investigation by independent national and international experts, the vaccine was reintroduced in 2010.
2269:
1044:
2306:
2274:
2103:
2053:
2364:
1229:
1974:
326:
311:
announced a US$ 110 million award from UNICEF to supply its pentavalent pediatric vaccine
Quinvaxem to the developing world.
1204:
2813:
2162:
1872:
1272:
2766:
1382:
1482:
1354:
452:
1432:
463:
Common versions of pentavalent vaccines include
Quinvaxem, Pentavac PFS, Easyfive TT, ComBE Five, Shan5, and Pentabio.
2747:
1114:"Shaping markets to benefit global health - A 15-year history and lessons learned from the pentavalent vaccine market"
685:"Shaping markets to benefit global health - A 15-year history and lessons learned from the pentavalent vaccine market"
318:
announced that the cost of the pentavalent vaccine for emerging-market countries had dropped below US$ 3.00 per dose.
650:
2284:
1726:
1709:
649:
World Health
Organization, World Health Organization Department of Immunization, Vaccines and Biologicals (2004).
2334:
1299:
1267:
1237:
1199:
944:
914:
852:
819:
594:
275:
264:
292:-containing vaccines procured by UNICEF, which supplies vaccines to a large proportion of the world's children.
2289:
2254:
2249:
2244:
496:
2828:
2735:
2668:
2649:
2445:
2417:
2379:
2374:
2354:
1882:
96:
597:'s list of pre-approved and prequalified vaccines in mid-2011. It was re-approved by WHO on 2 October 2013.
2716:
2645:
1644:
274:
In
September 2006, the first pentavalent vaccine formulation received pre-qualification approval from the
244:
205:
201:
2711:
2540:
1996:
1942:
1852:
522:
2838:
2833:
2594:
2535:
2326:
1969:
1847:
1798:
1765:
1699:
773:"A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador"
354:
1304:
2818:
2517:
2483:
2369:
2135:
2130:
2081:
1912:
1780:
1752:
1704:
1503:"Safety monitoring of a new pentavalent vaccine in the expanded programme on immunisation in Ghana"
535:
415:
372:
322:
282:
176:
142:
69:
57:
2550:
2384:
2125:
2091:
2076:
1952:
1922:
1842:
1760:
1532:
1501:
Dodoo AN, Renner L, van Grootheest AC, Labadie J, Antwi-Agyei KO, Hayibor S, et al. (2007).
1359:
1091:
849:"Public statement on Quintanrix: Withdrawal of the marketing authorisation in the European Union"
577:
209:
878:
2808:
2673:
2640:
2619:
2473:
2314:
2204:
2098:
1959:
1784:
1747:
1637:
1567:
1524:
1437:
1417:
1143:
1083:
794:
714:
656:
232:
86:
375:. It was later clarified that the undated vaccines were supplied by UNICEF and complied with
160:
152:
2823:
2599:
2584:
2440:
2301:
2214:
1557:
1514:
1133:
1125:
1075:
784:
704:
696:
368:
2780:
2604:
2402:
2209:
2167:
2038:
2008:
1991:
1917:
1907:
1837:
1776:
1772:
1721:
268:
371:, whereas the other set without manufacturing and expiry dates was being distributed to
2792:
2741:
2468:
2359:
2319:
2199:
2025:
1964:
1452:
1167:
1138:
1113:
1112:
Malhame M, Baker E, Gandhi G, Jones A, Kalpaxis P, Iqbal R, et al. (August 2019).
969:
709:
684:
683:
Malhame M, Baker E, Gandhi G, Jones A, Kalpaxis P, Iqbal R, et al. (August 2019).
509:
411:
252:
1546:"Pentavalent DTP vaccine: need to be incorporated in the vaccination program of India"
33:
2802:
2624:
2609:
2579:
2574:
2429:
2192:
2187:
2182:
2177:
2086:
1932:
1731:
1519:
1502:
1332:
1295:"Global Advisory Committee on Vaccine Safety, report of meeting held 12-13 June 2013"
964:
443:
296:
103:
1536:
909:
789:
772:
2701:
2344:
2239:
2172:
2113:
1937:
1793:
1684:
1664:
1095:
376:
248:
125:
120:
1079:
771:
Suárez E, Asturias EJ, Hilbert AK, Herzog C, Aeberhard U, Spyr C (February 2010).
584:
on April 20, 2006), which provides four out of the five vaccine elements in bulk.
267:
granted marketing approval to the pentavalent vaccine Quintanrix, manufactured by
960:"With GAVI support, pentavalent vaccine is available in the 73 poorest countries"
2488:
2478:
2339:
2145:
2140:
2058:
2033:
2001:
1927:
1789:
1680:
1672:
1457:
1129:
700:
623:
410:
introduced Easyfive-TT in September 2009. The identification of five cases with
396:
289:
240:
236:
216:
196:
45:
1473:"Pentavalent vaccine, Easyfive, removed from WHO list of prequalified vaccines"
1195:"Update on quality and safety of Quinvaxem (DTwP-HepB-Hib) pentavalent vaccine"
2614:
2589:
2279:
2229:
1390:
995:
184:
2663:
2234:
2107:
1676:
548:
387:
192:
1571:
1528:
1147:
1087:
798:
718:
1163:"Pentavalent vaccine maker claims Unicef exemption on manufacturing dates"
2505:
2498:
2493:
2463:
2219:
2155:
2150:
581:
223:, which supplies vaccines to a large proportion of the world's children.
17:
2224:
1986:
1668:
1615:"Health Organization, Gates Foundation Promote Greater Use of Vaccines"
483:
428:
308:
188:
180:
74:
62:
50:
2787:
2527:
2512:
1803:
1562:
1545:
1011:"Price of life-saving vaccine expected to drop significantly in 2011"
407:
220:
1589:"Drugs companies to lower price of vaccines in developing countries"
271:. Quintanrix was voluntarily withdrawn by the manufacturer in 2008.
1453:"Crucell Announces Product Approval in Korea for Quinvaxem Vaccine"
2522:
2407:
2013:
1947:
1328:"Infant deaths cast shadow on scale-up of pentavalent vaccine use"
573:
439:
427:
Between December 2012 and March 2013 nine deaths were reported in
1822:
1602:"Pentavalent vaccine gets clean chit, set for national scale-up"
392:
341:
The number of manufacturers making certified pentavalent vaccine
315:
1633:
1477:
391:
the authorities to suspend pentavalent vaccine use and resume
419:
international experts, the vaccine was reintroduced in 2011.
652:
Immunization in Practice: A Practical Guide for Health Staff
357:
almost vanished. Graph by GAVI; non-UNICEF prices not shown.
299:-supported countries to introduce the five-in-one vaccine.
247:
vaccine was found to have positive safety when given as a
1263:"Safety of Quinvaxem (DTwP-HepB-Hib) pentavalent vaccine"
572:
The vaccine was developed and manufactured by Crucell in
455:
released a statement in support of pentavalent vaccines.
736:"Diphtheria Tetanus and Pertussis Vaccine Supply Update"
288:
By 2013, pentavalent vaccines accounted for 100% of the
215:
By 2013, pentavalent vaccines accounted for 100% of the
447:
announced that Viet Nam would resume use of Quinvaxem.
2764:
1230:"Frequently Asked Questions (FAQs) Quinvaxem vaccine"
442:, Sri Lanka, and Bhutan of a small number of serious
2694:
2633:
2565:
2456:
2428:
2395:
2069:
1900:
1893:
1812:
1740:
1692:
141:
136:
110:
95:
85:
80:
68:
56:
44:
39:
624:"5-in-1 Vaccine (also called Pentavalent Vaccine)"
2680:Cedillo v. Secretary of Health and Human Services
992:"Crucell Announces New Award of $ 110 Million..."
813:"Quintanrix : EPAR - Summary for the public"
314:In November 2010, the public-private consortium
1433:"Crucell's Quinvaxem gets WHO prequalification"
295:In 2014, South Sudan became the last of the 73
159:
151:
1645:
325:that also contain inactivated polio vaccine (
8:
32:
212:, where polio vaccine is given separately.
1897:
1652:
1638:
1630:
1355:"Pentavalent vaccine is safe, assures IAP"
1107:
1105:
1561:
1544:Verma R, Khanna P, Chawla S (July 2013).
1518:
1363:. Express News Service. 13 September 2013
1257:
1255:
1224:
1222:
1189:
1187:
1185:
1137:
788:
708:
655:. World Health Organization. p. 20.
183:conjugated into one. It protects against
730:
728:
465:
353:All pentavalent vaccine prices fell and
2771:
1550:Human Vaccines & Immunotherapeutics
610:
565:
331:
31:
904:
902:
900:
777:Revista Panamericana de Salud PĂşblica
618:
616:
614:
91:Quintavax, Pentavac, Pentacel, others
7:
124:
2707:Eradication of infectious diseases
2464:Androvax (androstenedione albumin)
438:Following additional reports from
25:
2297:Respiratory syncytial virus (RSV)
219:-containing vaccines procured by
2786:
2774:
2686:Alternative vaccination schedule
1661:Artificial induction of immunity
1520:10.2165/00002018-200730040-00007
855:. 29 August 2008. Archived from
346:
334:
210:middle- and low-income countries
790:10.1590/S1020-49892010000200005
2518:Ovandrotone albumin (Fecundin)
1413:"'Shan5' vaccine gets WHO nod"
1326:Datta PT (22 September 2013).
1303:. 19 July 2013. Archived from
745:. October 2016. Archived from
593:Easyfive was removed from the
231:During studies and tests, the
1:
2054:Group B streptococcal disease
1873:Vaccines for Children Program
1271:. 10 May 2013. Archived from
1203:. 5 July 2013. Archived from
1080:10.1016/j.vaccine.2017.06.063
208:, which is generally used in
1161:Rajiv G (13 December 2013).
453:Indian Academy of Pediatrics
1130:10.1016/j.jvacx.2019.100033
910:"WHO Prequalified Vaccines"
701:10.1016/j.jvacx.2019.100033
2855:
1600:Dhar A (11 October 2013).
475:Date pre-qualified by WHO
2725:
1300:World Health Organization
1268:World Health Organization
1238:World Health Organization
1200:World Health Organization
1041:World Health Organization
945:World Health Organization
915:World Health Organization
883:European Medicines Agency
853:European Medicines Agency
820:European Medicines Agency
628:Vaccine Knowledge Project
582:Novartis International AG
544:
531:
518:
505:
492:
479:
474:
471:
468:
276:World Health Organization
265:European Medicines Agency
2049:Clostridioides difficile
1613:Sinha V (10 June 2011).
497:Serum Institute of India
2307:Tick-borne encephalitis
1587:Quinn B (6 June 2011).
1333:The Hindu Business Line
2717:List of vaccine topics
1717:Mathematical modelling
202:Haemophilus influenzae
2712:Vaccinate Your Family
2163:Japanese encephalitis
937:"Pentavalent Vaccine"
523:Biological E. Limited
263:In October 2004, the
179:with five individual
173:DTwP-HepB-Hib vaccine
34:DTwP-HepB-Hib vaccine
2814:Combination vaccines
2595:John Franklin Enders
580:(later purchased by
373:government hospitals
355:price discrimination
1781:Virus-like particle
1705:Vaccine ingredients
1307:on 22 December 2013
1275:on 11 November 2013
1047:on 11 February 2015
885:. 25 September 2018
576:and co-produced by
536:Shantha Biotechnics
416:meningoencephalitis
329:) are in wide use.
323:hexavalent vaccines
303:Society and culture
283:Government of India
177:combination vaccine
70:Haemophilus vaccine
58:Hepatitis B vaccine
36:
27:Combination vaccine
2752:Never to phase III
2551:Hexavalent vaccine
2365:Epstein–Barr virus
2260:Oxford–AstraZeneca
1953:NmVac4-A/C/Y/W-135
1485:on 12 August 2013.
1360:The Indian Express
1017:. 26 November 2010
578:Chiron Corporation
488:26 September 2006
2762:
2761:
2674:Vaccines and SIDS
2561:
2560:
2335:Hepatitis A and B
2311:Varicella zoster
1773:Subunit/component
1438:The Pharma Letter
1418:Business Standard
1207:on 30 August 2014
1074:(36): 5485–5494.
879:"Quintanrix EPAR"
557:
556:
553:19 December 2014
527:1 September 2011
369:private hospitals
170:
169:
16:(Redirected from
2846:
2791:
2790:
2779:
2778:
2777:
2770:
2653:MMR autism fraud
2600:Maurice Hilleman
2585:Hilary Koprowski
1898:
1654:
1647:
1640:
1631:
1626:
1625:on 5 March 2016.
1621:. Archived from
1619:Voice of America
1609:
1596:
1575:
1565:
1563:10.4161/hv.24382
1540:
1522:
1487:
1486:
1481:. Archived from
1469:
1463:
1462:
1449:
1443:
1442:
1429:
1423:
1422:
1409:
1403:
1402:
1400:
1398:
1389:. Archived from
1379:
1373:
1372:
1370:
1368:
1351:
1345:
1344:
1342:
1340:
1323:
1317:
1316:
1314:
1312:
1291:
1285:
1284:
1282:
1280:
1259:
1250:
1249:
1247:
1245:
1234:
1226:
1217:
1216:
1214:
1212:
1191:
1180:
1179:
1177:
1175:
1158:
1152:
1151:
1141:
1109:
1100:
1099:
1063:
1057:
1056:
1054:
1052:
1043:. Archived from
1037:"Vaccine Market"
1033:
1027:
1026:
1024:
1022:
1007:
1001:
1000:
999:(Press release).
988:
982:
981:
979:
977:
968:. Archived from
956:
950:
949:
941:
933:
927:
926:
924:
922:
906:
895:
894:
892:
890:
875:
869:
868:
866:
864:
845:
839:
838:
836:
834:
828:
822:. Archived from
817:
809:
803:
802:
792:
768:
762:
761:
759:
757:
751:
740:
732:
723:
722:
712:
680:
674:
673:
671:
669:
646:
640:
639:
637:
635:
620:
598:
591:
585:
570:
466:
350:
338:
163:
155:
150:Quintavax:
128:
119:Quintavax:
37:
35:
21:
2854:
2853:
2849:
2848:
2847:
2845:
2844:
2843:
2799:
2798:
2797:
2785:
2775:
2773:
2765:
2763:
2758:
2757:
2742:Clinical trials
2721:
2690:
2629:
2605:Stanley Plotkin
2567:
2557:
2469:Cancer vaccines
2452:
2446:Schistosomiasis
2424:
2418:Trypanosomiasis
2391:
2355:Cytomegalovirus
2265:Pfizer–BioNTech
2065:
1889:
1838:Vaccine wastage
1808:
1736:
1688:
1658:
1612:
1599:
1586:
1583:
1578:
1543:
1500:
1496:
1494:Further reading
1491:
1490:
1471:
1470:
1466:
1451:
1450:
1446:
1431:
1430:
1426:
1411:
1410:
1406:
1396:
1394:
1393:on 6 April 2016
1381:
1380:
1376:
1366:
1364:
1353:
1352:
1348:
1338:
1336:
1325:
1324:
1320:
1310:
1308:
1293:
1292:
1288:
1278:
1276:
1261:
1260:
1253:
1243:
1241:
1232:
1228:
1227:
1220:
1210:
1208:
1193:
1192:
1183:
1173:
1171:
1160:
1159:
1155:
1111:
1110:
1103:
1065:
1064:
1060:
1050:
1048:
1035:
1034:
1030:
1020:
1018:
1009:
1008:
1004:
990:
989:
985:
975:
973:
972:on 18 July 2014
958:
957:
953:
939:
935:
934:
930:
920:
918:
908:
907:
898:
888:
886:
877:
876:
872:
862:
860:
859:on 15 July 2018
847:
846:
842:
832:
830:
829:on 15 July 2018
826:
815:
811:
810:
806:
770:
769:
765:
755:
753:
752:on 29 June 2018
749:
738:
734:
733:
726:
682:
681:
677:
667:
665:
663:
648:
647:
643:
633:
631:
630:. 22 March 2018
622:
621:
612:
607:
602:
601:
592:
588:
571:
567:
562:
514:2 October 2013
461:
425:
405:
385:
365:
358:
351:
342:
339:
305:
269:GlaxoSmithKline
261:
229:
166:
158:Pentavac:
132:
98:
28:
23:
22:
15:
12:
11:
5:
2852:
2850:
2842:
2841:
2836:
2831:
2829:Whooping cough
2826:
2821:
2816:
2811:
2801:
2800:
2796:
2795:
2783:
2760:
2759:
2756:
2755:
2754:
2753:
2750:
2739:
2733:
2727:
2726:
2723:
2722:
2720:
2719:
2714:
2709:
2704:
2698:
2696:
2692:
2691:
2689:
2688:
2683:
2676:
2671:
2666:
2661:
2656:
2643:
2637:
2635:
2631:
2630:
2628:
2627:
2622:
2620:Katalin KarikĂł
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2582:
2577:
2571:
2569:
2563:
2562:
2559:
2558:
2556:
2555:
2554:
2553:
2548:
2543:
2538:
2530:
2525:
2520:
2515:
2510:
2509:
2508:
2503:
2502:
2501:
2496:
2486:
2481:
2476:
2466:
2460:
2458:
2454:
2453:
2451:
2450:
2449:
2448:
2443:
2434:
2432:
2426:
2425:
2423:
2422:
2421:
2420:
2412:
2411:
2410:
2399:
2397:
2393:
2392:
2390:
2389:
2388:
2387:
2382:
2377:
2375:Herpes simplex
2372:
2367:
2362:
2357:
2349:
2348:
2347:
2342:
2337:
2329:
2324:
2323:
2322:
2317:
2309:
2304:
2299:
2294:
2293:
2292:
2287:
2282:
2277:
2275:Sinopharm BIBP
2272:
2267:
2262:
2257:
2252:
2247:
2242:
2237:
2232:
2227:
2225:Bharat Biotech
2222:
2212:
2207:
2202:
2197:
2196:
2195:
2190:
2180:
2175:
2170:
2165:
2160:
2159:
2158:
2153:
2143:
2138:
2133:
2128:
2123:
2122:
2121:
2116:
2111:
2096:
2095:
2094:
2084:
2079:
2073:
2071:
2067:
2066:
2064:
2063:
2062:
2061:
2056:
2051:
2043:
2042:
2041:
2036:
2028:
2023:
2022:
2021:
2016:
2006:
2005:
2004:
1994:
1989:
1984:
1983:
1982:
1977:
1967:
1962:
1957:
1956:
1955:
1950:
1940:
1935:
1930:
1925:
1920:
1915:
1910:
1904:
1902:
1895:
1891:
1890:
1888:
1887:
1886:
1885:
1880:
1875:
1870:
1865:
1857:
1856:
1855:
1853:Vaccine injury
1850:
1845:
1840:
1835:
1830:
1825:
1816:
1814:
1813:Administration
1810:
1809:
1807:
1806:
1801:
1796:
1787:
1770:
1769:
1768:
1763:
1755:
1750:
1744:
1742:
1738:
1737:
1735:
1734:
1729:
1724:
1719:
1714:
1713:
1712:
1702:
1696:
1694:
1690:
1689:
1659:
1657:
1656:
1649:
1642:
1634:
1628:
1627:
1610:
1597:
1582:
1581:External links
1579:
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1576:
1541:
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1492:
1489:
1488:
1464:
1444:
1424:
1404:
1374:
1346:
1318:
1286:
1251:
1218:
1181:
1168:Times Of India
1153:
1101:
1058:
1028:
1002:
983:
951:
928:
896:
870:
840:
804:
763:
724:
675:
661:
641:
609:
608:
606:
603:
600:
599:
586:
564:
563:
561:
558:
555:
554:
551:
546:
542:
541:
540:29 April 2014
538:
533:
529:
528:
525:
520:
516:
515:
512:
510:Panacea Biotec
507:
503:
502:
499:
494:
490:
489:
486:
481:
477:
476:
473:
470:
460:
457:
444:adverse events
424:
421:
412:encephalopathy
404:
401:
384:
381:
364:
361:
360:
359:
352:
345:
343:
340:
333:
304:
301:
260:
257:
228:
225:
193:whooping cough
168:
167:
165:
164:
156:
147:
145:
139:
138:
134:
133:
131:
130:
116:
114:
108:
107:
101:
99:administration
93:
92:
89:
83:
82:
78:
77:
72:
66:
65:
60:
54:
53:
48:
42:
41:
40:Combination of
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2851:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2807:
2806:
2804:
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2782:
2772:
2768:
2751:
2749:
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2729:
2728:
2724:
2718:
2715:
2713:
2710:
2708:
2705:
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2700:
2699:
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2684:
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2675:
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2670:
2667:
2665:
2662:
2660:
2657:
2654:
2652:
2647:
2644:
2642:
2639:
2638:
2636:
2632:
2626:
2625:Drew Weissman
2623:
2621:
2618:
2616:
2613:
2611:
2610:H. Fred Clark
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2580:Louis Pasteur
2578:
2576:
2575:Edward Jenner
2573:
2572:
2570:
2564:
2552:
2549:
2547:
2546:DTwP-HepB-Hib
2544:
2542:
2541:DTaP-IPV-HepB
2539:
2537:
2534:
2533:
2532:combination:
2531:
2529:
2526:
2524:
2521:
2519:
2516:
2514:
2511:
2507:
2504:
2500:
2497:
2495:
2492:
2491:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2471:
2470:
2467:
2465:
2462:
2461:
2459:
2455:
2447:
2444:
2442:
2439:
2438:
2436:
2435:
2433:
2431:
2430:Helminthiasis
2427:
2419:
2416:
2415:
2413:
2409:
2406:
2405:
2404:
2401:
2400:
2398:
2394:
2386:
2383:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2352:
2350:
2346:
2343:
2341:
2338:
2336:
2333:
2332:
2331:combination:
2330:
2328:
2325:
2321:
2318:
2316:
2313:
2312:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2291:
2288:
2286:
2283:
2281:
2278:
2276:
2273:
2271:
2268:
2266:
2263:
2261:
2258:
2256:
2253:
2251:
2248:
2246:
2243:
2241:
2238:
2236:
2233:
2231:
2228:
2226:
2223:
2221:
2218:
2217:
2216:
2213:
2211:
2208:
2206:
2203:
2201:
2198:
2194:
2191:
2189:
2186:
2185:
2184:
2181:
2179:
2176:
2174:
2171:
2169:
2166:
2164:
2161:
2157:
2154:
2152:
2149:
2148:
2147:
2144:
2142:
2139:
2137:
2134:
2132:
2129:
2127:
2124:
2120:
2117:
2115:
2112:
2109:
2105:
2102:
2101:
2100:
2097:
2093:
2090:
2089:
2088:
2085:
2083:
2080:
2078:
2075:
2074:
2072:
2068:
2060:
2057:
2055:
2052:
2050:
2047:
2046:
2044:
2040:
2037:
2035:
2034:DPT/DTwP/DTaP
2032:
2031:
2030:combination:
2029:
2027:
2024:
2020:
2017:
2015:
2012:
2011:
2010:
2007:
2003:
2000:
1999:
1998:
1995:
1993:
1990:
1988:
1985:
1981:
1978:
1976:
1973:
1972:
1971:
1968:
1966:
1963:
1961:
1958:
1954:
1951:
1949:
1946:
1945:
1944:
1943:Meningococcus
1941:
1939:
1936:
1934:
1933:Leptospirosis
1931:
1929:
1926:
1924:
1921:
1919:
1916:
1914:
1911:
1909:
1906:
1905:
1903:
1899:
1896:
1892:
1884:
1881:
1879:
1876:
1874:
1871:
1869:
1868:Vaccine court
1866:
1864:
1861:
1860:
1858:
1854:
1851:
1849:
1846:
1844:
1841:
1839:
1836:
1834:
1831:
1829:
1826:
1824:
1823:GAVI Alliance
1821:
1820:
1818:
1817:
1815:
1811:
1805:
1802:
1800:
1797:
1795:
1791:
1788:
1786:
1782:
1778:
1774:
1771:
1767:
1764:
1762:
1759:
1758:
1756:
1754:
1751:
1749:
1746:
1745:
1743:
1739:
1733:
1730:
1728:
1725:
1723:
1720:
1718:
1715:
1711:
1708:
1707:
1706:
1703:
1701:
1698:
1697:
1695:
1691:
1686:
1682:
1678:
1674:
1670:
1666:
1662:
1655:
1650:
1648:
1643:
1641:
1636:
1635:
1632:
1624:
1620:
1616:
1611:
1607:
1603:
1598:
1594:
1590:
1585:
1584:
1580:
1573:
1569:
1564:
1559:
1556:(7): 1497–9.
1555:
1551:
1547:
1542:
1538:
1534:
1530:
1526:
1521:
1516:
1513:(4): 347–56.
1512:
1508:
1504:
1499:
1498:
1493:
1484:
1480:
1479:
1474:
1468:
1465:
1460:
1459:
1454:
1448:
1445:
1440:
1439:
1434:
1428:
1425:
1421:. 5 May 2014.
1420:
1419:
1414:
1408:
1405:
1392:
1388:
1387:Vaccine World
1384:
1378:
1375:
1362:
1361:
1356:
1350:
1347:
1335:
1334:
1329:
1322:
1319:
1306:
1302:
1301:
1296:
1290:
1287:
1274:
1270:
1269:
1264:
1258:
1256:
1252:
1240:
1239:
1231:
1225:
1223:
1219:
1206:
1202:
1201:
1196:
1190:
1188:
1186:
1182:
1170:
1169:
1164:
1157:
1154:
1149:
1145:
1140:
1135:
1131:
1127:
1123:
1119:
1115:
1108:
1106:
1102:
1097:
1093:
1089:
1085:
1081:
1077:
1073:
1069:
1062:
1059:
1046:
1042:
1038:
1032:
1029:
1016:
1012:
1006:
1003:
998:
997:
993:
987:
984:
971:
967:
966:
965:GAVI Alliance
961:
955:
952:
947:
946:
938:
932:
929:
917:
916:
911:
905:
903:
901:
897:
884:
880:
874:
871:
858:
854:
850:
844:
841:
825:
821:
814:
808:
805:
800:
796:
791:
786:
783:(2): 117–24.
782:
778:
774:
767:
764:
748:
744:
737:
731:
729:
725:
720:
716:
711:
706:
702:
698:
694:
690:
686:
679:
676:
664:
662:9789241546515
658:
654:
653:
645:
642:
629:
625:
619:
617:
615:
611:
604:
596:
590:
587:
583:
579:
575:
569:
566:
559:
552:
550:
547:
543:
539:
537:
534:
530:
526:
524:
521:
517:
513:
511:
508:
504:
501:23 June 2010
500:
498:
495:
493:Pentavac PFS
491:
487:
485:
482:
478:
472:Manufacturer
467:
464:
458:
456:
454:
448:
445:
441:
436:
432:
430:
422:
420:
417:
413:
409:
402:
400:
398:
394:
389:
382:
380:
378:
374:
370:
362:
356:
349:
344:
337:
332:
330:
328:
324:
319:
317:
312:
310:
307:In May 2010,
302:
300:
298:
293:
291:
286:
284:
279:
277:
272:
270:
266:
258:
256:
254:
250:
246:
242:
238:
234:
226:
224:
222:
218:
213:
211:
207:
204:
203:
198:
194:
190:
186:
182:
178:
174:
162:
157:
154:
149:
148:
146:
144:
140:
135:
127:
122:
118:
117:
115:
113:
109:
105:
104:Intramuscular
102:
100:
94:
90:
88:
84:
81:Clinical data
79:
76:
73:
71:
67:
64:
61:
59:
55:
52:
49:
47:
43:
38:
30:
19:
2702:Epidemiology
2678:
2650:
2545:
2536:DTaP-IPV/Hib
2327:Yellow fever
2240:EpiVacCorona
1997:Tuberculosis
1970:Pneumococcal
1938:Lyme disease
1766:Heterologous
1665:Immunization
1623:the original
1618:
1605:
1593:The Guardian
1592:
1553:
1549:
1510:
1506:
1483:the original
1476:
1467:
1456:
1447:
1436:
1427:
1416:
1407:
1397:17 September
1395:. Retrieved
1391:the original
1386:
1377:
1365:. Retrieved
1358:
1349:
1337:. Retrieved
1331:
1321:
1309:. Retrieved
1305:the original
1298:
1289:
1277:. Retrieved
1273:the original
1266:
1242:. Retrieved
1236:
1209:. Retrieved
1205:the original
1198:
1172:. Retrieved
1166:
1156:
1121:
1117:
1071:
1067:
1061:
1049:. Retrieved
1045:the original
1040:
1031:
1019:. Retrieved
1014:
1005:
994:
986:
974:. Retrieved
970:the original
963:
954:
943:
931:
919:. Retrieved
913:
887:. Retrieved
882:
873:
861:. Retrieved
857:the original
843:
831:. Retrieved
824:the original
807:
780:
776:
766:
754:. Retrieved
747:the original
742:
692:
688:
678:
666:. Retrieved
651:
644:
632:. Retrieved
627:
589:
568:
506:Easyfive TT
462:
459:Formulations
449:
437:
433:
426:
406:
386:
366:
320:
313:
309:Crucell N.V.
306:
294:
287:
280:
273:
262:
230:
214:
200:
175:is a 5-in-1
172:
171:
161:1688606-53-2
153:1196465-46-9
29:
2839:Hepatitis B
2834:Haemophilus
2738:from market
2634:Controversy
2568:researchers
2484:Hepatitis B
2370:Hepatitis C
2315:Chicken pox
2141:Hepatitis E
2136:Hepatitis B
2131:Hepatitis A
2082:Chikungunya
2059:Shigellosis
1913:Brucellosis
1799:Therapeutic
1753:Inactivated
1693:Development
1681:Inoculation
1673:Vaccination
1507:Drug Safety
1458:Marketwired
519:ComBE Five
397:hepatitis B
253:immunogenic
197:hepatitis B
137:Identifiers
87:Trade names
46:DTP vaccine
2819:Diphtheria
2803:Categories
2669:Thiomersal
2615:Paul Offit
2590:Jonas Salk
2566:Inventors/
2437:research:
2414:research:
2351:research:
2280:Skycovione
2270:Sanofi–GSK
2215:SARS-CoV-2
2126:Hantavirus
2092:rVSV-ZEBOV
2077:Adenovirus
2045:research:
1923:Diphtheria
1761:Attenuated
1383:"Products"
1124:: 100033.
996:PRNewswire
976:7 December
889:13 October
695:: 100033.
605:References
480:Quinvaxem
377:Indian Law
233:conjugated
185:diphtheria
143:CAS Number
2748:Phase III
2736:Withdrawn
2664:Pox party
2474:ALVAC-CEA
2396:Protozoan
2285:Sputnik V
2235:CoronaVac
2205:Rotavirus
2108:Pandemrix
1960:Pertussis
1901:Bacterial
1785:Synthetic
1748:Conjugate
1700:Adjuvants
1677:Infection
1606:The Hindu
549:Bio Farma
545:Pentabio
388:Sri Lanka
383:Sri Lanka
106:injection
97:Routes of
18:Quinvaxem
2809:Vaccines
2781:Medicine
2506:Prostvac
2499:Gardasil
2494:Cervarix
2441:Hookworm
2320:Shingles
2302:Smallpox
2220:Corbevax
2156:Gardasil
2151:Cervarix
1894:Vaccines
1848:Schedule
1819:Global:
1727:Timeline
1669:Vaccines
1572:23571225
1537:37633844
1529:17408311
1148:31384748
1088:28676382
799:20339615
719:31384748
469:Vaccine
429:Viet Nam
181:vaccines
112:ATC code
2824:Tetanus
2793:Viruses
2767:Portals
2695:Related
2641:General
2403:Malaria
2290:Valneva
2255:Novavax
2250:Moderna
2245:Janssen
2230:CanSino
2210:Rubella
2168:Measles
2039:Td/Tdap
2009:Typhoid
1992:Tetanus
1987:Q fever
1918:Cholera
1908:Anthrax
1777:Peptide
1741:Classes
1722:Storage
1279:30 June
1244:30 June
1139:6668221
1118:Vaccine
1096:4384043
1068:Vaccine
1051:28 June
921:29 June
863:15 July
833:15 July
756:28 June
710:6668221
689:Vaccine
668:15 July
484:Crucell
423:Vietnam
414:and/or
259:History
249:booster
235:liquid
189:tetanus
129:)
123: (
121:J07CA11
75:Vaccine
63:Vaccine
51:Vaccine
2731:WHO-EM
2651:Lancet
2528:TA-NIC
2513:NicVAX
2360:Dengue
2200:Rabies
2026:Typhus
1965:Plague
1843:Policy
1804:Toxoid
1732:Trials
1570:
1535:
1527:
1367:3 July
1339:3 July
1311:3 July
1211:3 July
1174:3 July
1146:
1136:
1094:
1086:
1021:3 July
797:
743:UNICEF
717:
707:
659:
634:3 July
532:Shan5
408:Bhutan
403:Bhutan
227:Safety
221:UNICEF
206:type B
2659:NCVIA
2523:TA-CD
2457:Other
2408:RTS,S
2188:Sabin
2183:Polio
2178:Mumps
2087:Ebola
2070:Viral
2019:ViCPS
2014:Ty21a
1948:MeNZB
1878:VAERS
1828:NITAG
1757:Live
1533:S2CID
1233:(PDF)
1092:S2CID
940:(PDF)
827:(PDF)
816:(PDF)
750:(PDF)
739:(PDF)
574:Korea
560:Notes
440:India
363:India
2385:Zika
2345:MMRV
2193:Salk
2173:Mpox
2119:LAIV
2114:H5N1
2104:H1N1
1980:PPSV
1863:ACIP
1859:US:
1833:SAGE
1794:mRNA
1710:list
1568:PMID
1525:PMID
1399:2014
1369:2018
1341:2018
1313:2018
1281:2018
1246:2018
1213:2018
1176:2018
1144:PMID
1084:PMID
1053:2018
1023:2018
1015:GAVI
978:2015
923:2018
891:2023
865:2018
835:2018
795:PMID
758:2018
715:PMID
670:2018
657:ISBN
636:2018
395:and
393:DTwP
316:GAVI
297:GAVI
241:HepB
237:DTPw
199:and
2646:MMR
2489:HPV
2479:BCG
2380:HIV
2340:MMR
2146:HPV
2099:Flu
2002:BCG
1975:PCV
1928:Hib
1883:VSD
1790:DNA
1685:J07
1558:doi
1515:doi
1478:WHO
1134:PMC
1126:doi
1076:doi
785:doi
705:PMC
697:doi
595:WHO
327:IPV
290:DTP
245:Hib
217:DTP
126:WHO
2805::
2744::
1792:/
1783:/
1779:/
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