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in 2003. She led early clinical trials testing a combination of rucaparib (AG014699) and temozolomide in patients with advanced solid tumours, discovering that it well tolerated. She has also led early-stage trials that determined the safety of the combination of rucaparib and the chemotherapy drug
326:
Plummer was elected a fellow of the
Academy of Medical Sciences in 2018 ." The Academy cited that she “has a world-leading reputation in the design and delivery of early phase clinical trials. She has taken many new cancer drugs into the clinic to determine their optimal dose, which have then
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NHS Foundation Trust. She is
Director of the Sir Bobby Robson Cancer Trials Research Centre within the Northern Centre for Cancer Care, w a dedicated clinical trials unit within the regional cancer centre. . Plummer also leads the Newcastle Experimental Cancer Medicine Centre and the CRUK
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She chairs the Cancer
Research UK New Agents Committee and the Scientific Advisory Board for Target Ovarian Cancer. She is a member of Cancer Research UK’s Clinical Research Committee and the
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884:
606:"Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial"
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Plummer is
Professor of Experimental Cancer Medicine at the Northern Institute for Cancer Research, Newcastle University and an honorary consultant medical oncologist in
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Middleton M, Plummer, R (2016). "Phase I trial of first-in-class ATR inhibitor VX-970 in combination with gemcitabine (Gem) in advanced solid tumors (NCT02157792) ".
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She then moved back to
Newcastle, working at the Northern Institute for Cancer Research at Newcastle University. She lists her research interests as
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318:’s Stratified Medicines Group. She sits on the clinical advisory board for Karus Therapeutics, and is a scientific advisor for CV6 Therapeutics.
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She has also led studies bringing a new type of drug, ATR inhibitor, into the clinic through early-stage clinical trials. ATR, which stands for
874:
480:"Phase I Study Of The Poly(ADP-Ribose) Polymerase Inhibitor, AG014699, In Combination With Temozolomide in Patients with Advanced Solid Tumors"
308:
773:
397:
330:
She won a
Translational Cancer Research Prize from Cancer Research UK for this work in 2010 for her work on PARP inhibitor trials.
59:
44:
Please help improve this article by looking for better, more reliable sources. Unreliable citations may be challenged and removed.
432:
543:"A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours"
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to run early-stage clinical trials.v
Plummer and the Newcastle team won a 2010 Translational Cancer Research Prize from
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was given accelerated approval in the US by the FDA in 2016 and received a conditional licence by the EU in 2018.
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Plummer was the first clinician to write a prescription for the cancer drug
Rucaparib, a
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311:, regulates how cells respond to stress and can help promote DNA repair.
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698:"First PARP inhibitor licensed for ovarian treatment indication in the EU"
682:"Cancer drug invented by Newcastle University approved for use in Europe"
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433:"Meet the cancer patient who says Sir Bobby Robson helped save her life"
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to treat ovarian cancer. Plummer was elected as a fellow of the UK's
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for advanced solid tumours, Following successful clinical trials,
774:"New Chair for Target Ovarian Cancer's Scientific Advisory Board"
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463:"Rucaparib: targeting DNA repair and a patient's perspective"
667:"Development History and FDA Approval Process for Rubraca"
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become standard treatments with proven patient benefit.”
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and completed a PhD and her clinical studies at the
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220:is a Professor of Experimental Cancer Medicine at
194:Newcastle upon Tyne Hospitals NHS Foundation Trust
190:Sir Bobby Robson Cancer Trials Research Centre
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260:Plummer studied pre-clinical medicine at the
236:Cancer Trials Research Centre, set up by the
129:Early stage clinical trials, Drug development
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860:Academy of Medical Sciences (United Kingdom)
744:: CS1 maint: multiple names: authors list (
652:: CS1 maint: multiple names: authors list (
604:Ledermann, J, Coleman, R (3 November 2017).
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885:Members of the Order of the British Empire
478:Calvert, H, Plummer, R (1 December 2008).
232:. Based in Newcastle, she directs the Sir
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398:"Fellow - Professor Ruth Plummer FMedSci"
335:Member of the Order of the British Empire
60:Learn how and when to remove this message
16:Professor of Experimental Cancer Medicine
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828:(Supplement). 1 June 2022. p. B23.
804:"Scientific Advisors - Ruth Plummer MD"
541:Plummer, R, Wilson, R (28 March 2017).
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228:specialising in treating patients with
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422:Northern Institute for Cancer Research
309:Ataxia telangiectasia and Rad3 related
850:Alumni of the University of Cambridge
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360:"Translational Cancer Research Prize"
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870:21st-century British medical doctors
275:and the early trials of new drugs.
146:Translational Cancer Research prize
855:Alumni of the University of Oxford
14:
865:Academics of Newcastle University
378:"New Fellows for 2018 announced"
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402:The Academy of Medical Sciences
382:The Academy of Medical Sciences
1:
875:British women medical doctors
622:10.1016/S0140-6736(17)32440-6
496:10.1158/1078-0432.CCR-08-1223
341:for services to medicine.
250:Academy of Medical Sciences
238:Sir Bobby Robson Foundation
142:Academy of Medical Sciences
906:
718:European Medicines Agency
547:British Journal of Cancer
283:Newcastle Cancer Centre.
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789:"Professor Ruth Plummer"
448:"Professor Ruth Plummer"
418:"Professor Ruth Plummer"
316:Medical Research Council
759:"News Agents Committee"
262:University of Cambridge
112:University of Cambridge
32:Some of this article's
333:Plummer was appointed
209:Elizabeth Ruth Plummer
778:Target Ovarian Cancer
339:2022 Birthday Honours
616:(10106): 1949–1961.
266:University of Oxford
256:Education and career
222:Newcastle University
186:Newcastle University
117:University of Oxford
890:British oncologists
559:10.1038/bjc.2017.36
880:Cancer researchers
825:The London Gazette
793:Karus Therapeutics
763:Cancer Research UK
467:Cancer Research UK
452:Cancer Research UK
364:Cancer Research UK
322:Honours and awards
280:Newcastle Hospital
242:Cancer Research UK
702:The Pharma Letter
490:(23): 7917–7923.
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155:Scientific career
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553:(7): 884–892.
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437:Chronicle Live
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50:December 2020
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740:cite journal
732:J Clin Oncol
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648:cite journal
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234:Bobby Robson
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179:Institutions
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80:Ruth Plummer
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36:
820:"No. 63714"
720:30 May 2018
704:30 May 2018
298:carboplatin
97:Citizenship
37:may not be
839:Categories
610:The Lancet
345:References
273:DNA repair
226:oncologist
714:"Rubraca"
671:Drugs.com
302:Rucaparib
252:in 2018.
246:rucaparib
140:Fellow,
686:ITV News
640:28916367
577:28222073
514:19047122
230:melanoma
165:melanoma
39:reliable
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568:5379148
505:2652879
224:and an
217:FMedSci
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161:Fields
134:Awards
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746:link
654:link
636:PMID
591:link
573:PMID
528:link
510:PMID
626:PMC
618:doi
614:390
563:PMC
555:doi
551:116
500:PMC
492:doi
213:MBE
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
