253:
230:
127:
152:
259:
158:
1556:
266:
165:
1536:
1206:"Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis"
683:
664:
88:
1504:
Lei X, Li YM (December 2009). "The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity".
1625:
1120:
1601:
1102:
1620:
1428:"Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain"
252:
906:
899:
229:
1089:
1068:
1085:
151:
126:
1064:
1032:
68:
1309:
Pascall JC, Brown KD (April 2004). "Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2".
265:
164:
258:
157:
1594:
982:
1012:
728:
76:
1157:"Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments"
1028:
1024:
709:
1587:
1386:
1217:
140:
55:
882:
853:
827:
802:
1204:
Johnson N, BΕezinovΓ‘ J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K (August 2017).
1492:
100:
878:
857:
823:
798:
1521:
1484:
1449:
1414:
1361:
1326:
1297:
1243:
1186:
978:
48:
1571:
1513:
1474:
1439:
1404:
1394:
1351:
1318:
1287:
1279:
1233:
1225:
1176:
1168:
345:
276:
220:
175:
96:
1016:
1001:
320:
1390:
1221:
1027:; profiling of the substrate repertoire of RHBDL2 has identified a number of additional
1409:
1374:
1292:
1267:
1238:
1205:
1181:
1156:
1020:
1479:
1462:
1444:
1427:
1375:"Inherited genetic variant predisposes to aggressive but not indolent prostate cancer"
598:
593:
577:
572:
567:
551:
546:
541:
536:
1614:
1540:
523:
1373:
Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, et al. (February 2010).
80:
1567:
1496:
1463:"Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases"
338:
117:
1340:"Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing"
104:
1338:
Cheng TL, Wu YT, Lin HY, Hsu FC, Liu SK, Chang BI, et al. (December 2011).
1125:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1107:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1379:
Proceedings of the
National Academy of Sciences of the United States of America
1322:
1229:
421:
1517:
993:
989:
986:
237:
134:
84:
1399:
1172:
997:
628:
481:
359:
304:
291:
203:
190:
92:
1525:
1488:
1453:
1418:
1365:
1330:
1301:
1247:
1190:
1283:
1138:
946:
941:
1356:
1339:
1266:
Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M (May 2011).
1008:
930:
773:
754:
962:
740:
695:
17:
1036:
914:
650:
1555:
1268:"Mammalian EGF receptor activation by the rhomboid protease RHBDL2"
1040:
613:
609:
1563:
966:
72:
328:
1575:
1155:
Lichtenthaler SF, Lemberg MK, Fluhrer R (August 2018).
493:
1150:
1148:
1139:"Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila)"
985:. This family contains proteins that are related to
977:
The protein encoded by this gene is a member of the
1311:
871:
846:
816:
791:
1081:
1079:
1077:
1060:
1058:
1056:
275:
174:
27:Protein-coding gene in the species Homo sapiens
1086:GRCm38: Ensembl release 89: ENSMUSG00000043333
1595:
1000:and are thought to function as intramembrane
8:
1461:Urban S, Lee JR, Freeman M (October 2001).
1065:GRCh38: Ensembl release 89: ENSG00000158315
992:. Members of this family are found in both
1602:
1588:
1537:United States National Library of Medicine
624:
519:
464:transitional epithelium of urinary bladder
316:
215:
112:
1478:
1443:
1408:
1398:
1355:
1291:
1237:
1180:
1535:This article incorporates text from the
1344:The Journal of Investigative Dermatology
965:that in humans is encoded by the RHBDL2
1052:
29:
1019:. Known substrates of RHBDL2 include
280:
241:
236:
179:
138:
133:
7:
1552:
1550:
1574:. You can help Knowledge (XXG) by
868:
843:
813:
788:
764:
745:
719:
700:
674:
655:
547:serine-type endopeptidase activity
498:
416:
354:
333:
25:
1554:
1426:Urban S, Freeman M (June 2003).
264:
257:
251:
228:
163:
156:
150:
125:
568:integral component of membrane
542:serine-type peptidase activity
482:More reference expression data
1:
1626:Human chromosome 1 gene stubs
1480:10.1016/s0092-8674(01)00525-6
1445:10.1016/s1097-2765(03)00181-3
249:
148:
1506:Journal of Molecular Biology
1621:Genes on human chromosome 1
1642:
1549:
1323:10.1016/j.bbrc.2004.03.039
1230:10.1038/s41598-017-07556-3
983:integral membrane proteins
959:Rhomboid-related protein 2
378:mucosa of transverse colon
1518:10.1016/j.jmb.2009.10.025
1121:"Mouse PubMed Reference:"
1103:"Human PubMed Reference:"
945:
940:
936:
929:
913:
907:Chr 4: 123.68 β 123.72 Mb
894:
875:
850:
839:
820:
795:
784:
771:
767:
752:
748:
739:
726:
722:
707:
703:
694:
681:
677:
662:
658:
649:
634:
627:
623:
607:
522:
518:
506:
501:
492:
479:
428:
419:
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
1029:type I membrane proteins
1400:10.1073/pnas.0914061107
1173:10.15252/embj.201899456
1025:epidermal growth factor
900:Chr 1: 38.89 β 38.94 Mb
370:mucosa of sigmoid colon
59:, RRP2, rhomboid like 2
1031:substrates, including
1007:RHBDL2 functions as a
1284:10.1038/embor.2011.50
406:palpebral conjunctiva
1357:10.1038/jid.2011.230
243:Chromosome 4 (mouse)
141:Chromosome 1 (human)
1391:2010PNAS..107.2136X
1222:2017NatSR...7.7283J
1562:This article on a
1539:, which is in the
1210:Scientific Reports
729:ENSMUSG00000043333
594:protein processing
587:Biological process
561:Cellular component
552:hydrolase activity
537:peptidase activity
530:Molecular function
105:RHBDL2 - orthologs
1583:
1582:
979:rhomboid protease
956:
955:
952:
951:
925:
924:
890:
889:
865:
864:
835:
834:
810:
809:
780:
779:
761:
760:
735:
734:
716:
715:
690:
689:
671:
670:
619:
618:
514:
513:
510:
509:
488:
487:
475:
474:
413:
412:
311:
310:
210:
209:
16:(Redirected from
1633:
1604:
1597:
1590:
1558:
1551:
1529:
1500:
1482:
1457:
1447:
1422:
1412:
1402:
1369:
1359:
1334:
1305:
1295:
1252:
1251:
1241:
1201:
1195:
1194:
1184:
1161:The EMBO Journal
1152:
1143:
1142:
1135:
1129:
1128:
1117:
1111:
1110:
1099:
1093:
1083:
1072:
1062:
1002:serine proteases
938:
937:
909:
902:
885:
869:
860:
844:
840:RefSeq (protein)
830:
814:
805:
789:
765:
746:
720:
701:
675:
656:
625:
520:
499:
484:
432:lobe of prostate
424:
422:Top expressed in
417:
402:nasal epithelium
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
58:
51:
30:
21:
1641:
1640:
1636:
1635:
1634:
1632:
1631:
1630:
1611:
1610:
1609:
1608:
1547:
1532:
1503:
1460:
1425:
1372:
1350:(12): 2486β94.
1337:
1308:
1265:
1261:
1259:Further reading
1256:
1255:
1203:
1202:
1198:
1154:
1153:
1146:
1137:
1136:
1132:
1119:
1118:
1114:
1101:
1100:
1096:
1084:
1075:
1063:
1054:
1049:
1017:plasma membrane
975:
947:View/Edit Mouse
942:View/Edit Human
905:
898:
895:Location (UCSC)
881:
877:
856:
852:
826:
822:
801:
797:
710:ENSG00000158315
603:
582:
573:plasma membrane
556:
480:
471:
466:
462:
458:
454:
450:
446:
442:
440:membranous bone
438:
434:
420:
409:
404:
400:
398:corpus callosum
396:
392:
390:skin of abdomen
388:
384:
380:
376:
372:
358:
302:
289:
281:
271:
270:
269:
262:
242:
219:Gene location (
201:
188:
180:
170:
169:
168:
161:
139:
116:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
1639:
1637:
1629:
1628:
1623:
1613:
1612:
1607:
1606:
1599:
1592:
1584:
1581:
1580:
1559:
1531:
1530:
1501:
1458:
1438:(6): 1425β34.
1432:Molecular Cell
1423:
1385:(5): 2136β40.
1370:
1335:
1306:
1262:
1260:
1257:
1254:
1253:
1196:
1144:
1130:
1112:
1094:
1073:
1051:
1050:
1048:
1045:
1021:thrombomodulin
974:
971:
954:
953:
950:
949:
944:
934:
933:
927:
926:
923:
922:
920:
918:
911:
910:
903:
896:
892:
891:
888:
887:
873:
872:
866:
863:
862:
848:
847:
841:
837:
836:
833:
832:
818:
817:
811:
808:
807:
793:
792:
786:
782:
781:
778:
777:
769:
768:
762:
759:
758:
750:
749:
743:
737:
736:
733:
732:
724:
723:
717:
714:
713:
705:
704:
698:
692:
691:
688:
687:
679:
678:
672:
669:
668:
660:
659:
653:
647:
646:
641:
636:
632:
631:
621:
620:
617:
616:
605:
604:
602:
601:
596:
590:
588:
584:
583:
581:
580:
575:
570:
564:
562:
558:
557:
555:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
504:
503:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
448:Dermatocranium
445:
441:
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1638:
1627:
1624:
1622:
1619:
1618:
1616:
1605:
1600:
1598:
1593:
1591:
1586:
1585:
1579:
1577:
1573:
1569:
1565:
1560:
1557:
1553:
1548:
1545:
1544:
1542:
1541:public domain
1538:
1527:
1523:
1519:
1515:
1512:(5): 815β25.
1511:
1507:
1502:
1498:
1494:
1490:
1486:
1481:
1476:
1473:(2): 173β82.
1472:
1468:
1464:
1459:
1455:
1451:
1446:
1441:
1437:
1433:
1429:
1424:
1420:
1416:
1411:
1406:
1401:
1396:
1392:
1388:
1384:
1380:
1376:
1371:
1367:
1363:
1358:
1353:
1349:
1345:
1341:
1336:
1332:
1328:
1324:
1320:
1317:(1): 244β52.
1316:
1312:
1307:
1303:
1299:
1294:
1289:
1285:
1281:
1277:
1273:
1269:
1264:
1263:
1258:
1249:
1245:
1240:
1235:
1231:
1227:
1223:
1219:
1215:
1211:
1207:
1200:
1197:
1192:
1188:
1183:
1178:
1174:
1170:
1166:
1162:
1158:
1151:
1149:
1145:
1140:
1134:
1131:
1126:
1122:
1116:
1113:
1108:
1104:
1098:
1095:
1091:
1087:
1082:
1080:
1078:
1074:
1070:
1066:
1061:
1059:
1057:
1053:
1046:
1044:
1042:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1005:
1003:
999:
995:
991:
988:
984:
980:
972:
970:
968:
964:
960:
948:
943:
939:
935:
932:
928:
921:
919:
916:
912:
908:
904:
901:
897:
893:
886:
884:
880:
874:
870:
867:
861:
859:
855:
849:
845:
842:
838:
831:
829:
825:
819:
815:
812:
806:
804:
800:
794:
790:
787:
785:RefSeq (mRNA)
783:
776:
775:
770:
766:
763:
757:
756:
751:
747:
744:
742:
738:
731:
730:
725:
721:
718:
712:
711:
706:
702:
699:
697:
693:
686:
685:
680:
676:
673:
667:
666:
661:
657:
654:
652:
648:
645:
642:
640:
637:
633:
630:
626:
622:
615:
611:
606:
600:
597:
595:
592:
591:
589:
586:
585:
579:
576:
574:
571:
569:
566:
565:
563:
560:
559:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
368:
365:
361:
356:
353:
352:
349:
347:
343:
341:
340:
336:
335:
332:
330:
326:
322:
318:
314:
306:
301:
297:
293:
288:
282:4|4 D2.2
278:
274:
267:
260:
254:
247:
239:
235:
231:
226:
222:
217:
213:
205:
200:
196:
192:
187:
177:
173:
166:
159:
153:
146:
142:
136:
132:
128:
123:
119:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
1576:expanding it
1568:chromosome 1
1561:
1546:
1534:
1533:
1509:
1505:
1470:
1466:
1435:
1431:
1382:
1378:
1347:
1343:
1314:
1310:
1278:(5): 421β7.
1275:
1272:EMBO Reports
1271:
1213:
1209:
1199:
1164:
1160:
1133:
1124:
1115:
1106:
1097:
1006:
976:
958:
957:
883:NP_001343374
876:
854:NP_001291675
851:
828:NM_001356445
821:
803:NM_001304746
796:
772:
753:
727:
708:
682:
663:
643:
638:
344:
337:
303:123,723,697
290:123,681,667
64:External IDs
1216:(1): 7283.
994:prokaryotes
599:proteolysis
394:oral cavity
386:skin of leg
202:38,941,830
189:38,885,807
42:Identifiers
1615:Categories
1092:, May 2017
1071:, May 2017
1047:References
998:eukaryotes
990:rhomboid-1
987:Drosophila
981:family of
456:blastocyst
436:left colon
382:C1 segment
348:(ortholog)
85:HomoloGene
1566:on human
1013:localized
879:NP_898986
858:NP_060291
824:NM_183163
799:NM_017821
629:Orthologs
93:GeneCards
1526:19850051
1489:11672525
1454:12820957
1419:20080650
1366:21833011
1331:15047175
1302:21494248
1248:28779096
1191:29976761
1088:–
1067:–
1009:sheddase
973:Function
931:Wikidata
608:Sources:
578:membrane
468:duodenum
452:mandible
444:calvaria
1497:9026083
1410:2836698
1387:Bibcode
1293:3090019
1239:5544772
1218:Bibcode
1182:6068445
1090:Ensembl
1069:Ensembl
1015:to the
1011:and is
963:protein
741:UniProt
696:Ensembl
635:Species
614:QuickGO
460:maxilla
323:pattern
81:3608413
49:Aliases
1524:
1495:
1487:
1452:
1417:
1407:
1364:
1329:
1300:
1290:
1246:
1236:
1189:
1179:
1167:(15).
1039:, and
1037:SPINT1
917:search
915:PubMed
774:A2AGA4
755:Q9NX52
684:230726
651:Entrez
494:BioGPS
374:rectum
181:1p34.3
97:RHBDL2
73:608962
56:RHBDL2
33:RHBDL2
18:RHBDL2
1570:is a
1493:S2CID
1041:CLCP1
961:is a
665:54933
644:Mouse
639:Human
610:Amigo
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
89:49508
1572:stub
1564:gene
1522:PMID
1485:PMID
1467:Cell
1450:PMID
1415:PMID
1362:PMID
1327:PMID
1298:PMID
1244:PMID
1187:PMID
1033:BCAM
1023:and
996:and
967:gene
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
69:OMIM
1514:doi
1510:394
1475:doi
1471:107
1440:doi
1405:PMC
1395:doi
1383:107
1352:doi
1348:131
1319:doi
1315:317
1288:PMC
1280:doi
1234:PMC
1226:doi
1177:PMC
1169:doi
1004:.
502:n/a
299:End
198:End
101:OMA
77:MGI
1617::
1520:.
1508:.
1491:.
1483:.
1469:.
1465:.
1448:.
1436:11
1434:.
1430:.
1413:.
1403:.
1393:.
1381:.
1377:.
1360:.
1346:.
1342:.
1325:.
1313:.
1296:.
1286:.
1276:12
1274:.
1270:.
1242:.
1232:.
1224:.
1212:.
1208:.
1185:.
1175:.
1165:37
1163:.
1159:.
1147:^
1123:.
1105:.
1076:^
1055:^
1043:.
1035:,
969:.
612:/
305:bp
292:bp
204:bp
191:bp
99:;
95::
91:;
87::
83:;
79::
75:;
71::
1603:e
1596:t
1589:v
1578:.
1543:.
1528:.
1516::
1499:.
1477::
1456:.
1442::
1421:.
1397::
1389::
1368:.
1354::
1333:.
1321::
1304:.
1282::
1250:.
1228::
1220::
1214:7
1193:.
1171::
1141:.
1127:.
1109:.
223:)
120:)
103::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
