2119:
while p27 levels are regulated using effector Rho-associated kinases. Cytokinesis is defined by actomyosin-based contraction. RhoA-dependent diaphanous-related formins (DRFs) localize to the cleavage furrow during cytokinesis while stimulating local actin polymerization by coordinating microtubules with actin filaments at the site of the myosin contractile ring. Differences in effector binding distinguish RhoA amongst other related Ras homologs GTPases. Integrins can modulate RhoA activity depending on the extracellular matrix composition and other relevant factors. Similarly, RhoA's stimulation of PKN2 kinase activity regulates cell-cell adhesion through apical junction formation and disassembly. Though RhoA is most easily recognized from its unique contributions in actin-myosin contractility and stress fiber formation, new research has also identified it as a key factor in the mediation of membrane ruffling, lamellae formation and membrane blebbing. A majority of this activity occurs in the leading edge of cells during migration in coordination with membrane protrusions of breast carcinoma.
2346:
the level of both their expression and activation, and a reciprocal relationship between RhoA and Rac1 activation. Chronic
Myeloid Leukemia (CML), a stem cell disorder that prevents myeloid cells from functioning correctly, has been linked to actin polymerization. Signaling proteins like RhoA, regulate polymerization of actin. Due to differences proteins exhibited between normal and affected neutrocytes, RhoA has become the key element; further experimentation has also shown that RhoA-inhibiting pathways prevent the overall growth of CML cells. As a result, RhoA has significant potential as a therapeutic target in gene therapy techniques to treating CML. Therefore, RhoA's role in the proliferation of cancer cell phenotypes is a key application that can be applied to targeted cancer therapeutics and the development for pharmaceuticals.
2337:
as a highly-promising anti-cancer drug that is also being utilized in chemotherapy treatments; however, as with nearly all chemotherapeutics, the issue of drug resistance remains. Minimizing or postponing this resistance would the necessary dose to eradicate the tumor, thus diminishing drug toxicity. Subsequent RhoA expression decrease has also been associated with increased sensitivity to doxorubicin and the complete reversion of doxorubicin resistance in certain cells; this shows the resilience of RhoA as a consistent indicator anti-cancer activity. In addition to promoting tumor-suppression activity, RhoA also has inherent impact upon the efficacy of drugs in relation to cancer functionality and could be applied to gene therapy protocols in future research.
2078:) of migrating cells to promote detachment, similar to the attachment and detachment process found in the focal adhesion mechanism. Signal transduction pathways regulated via RhoA link plasma membrane receptors to focal adhesion formation and the subsequent activation of relevant actin stress fibers. RhoA directly stimulates actin polymerization through activation of diaphanous-related formins, thereby structurally changing the actin monomers to filaments. ROCK kinases induce actomyosin-based contractility and phosphorylate TAU and MAP2 involved in regulating myosins and other actin-binding proteins in order to assist in cell migration and detachment. The concerted action of
2105:
signal activity. It has also been shown that RhoA mediates serum-, LPA- and AIF4-induced signaling pathways in addition to regulating the transcription of the c-fos promoter, a key component in the formation of the ternary complex producing the serum and ternary factors. RhoA signaling and modulation of actin polymerization also regulates Sox9 expression via controlling transcriptional Sox9 activity. The expression and transcriptional activity of Sox9 is directly linked with the loss of RhoA activity and illustrates how RhoA participates in the transcriptional control of specific protein expression.
2333:
roles ranging from distinguishing benign from malignant prostate and identifying aggressive disease. RhoA mediates androgen-responsiveness of these SRF genes; as a result, interference with RhoA has been shown to prevent the androgen regulation of SRF genes. In application, RhoA expression is notably higher in malignant prostate cancer cells compared to benign prostate cells, with elevated RhoA expression being associated with elevated lethality and aggressive proliferation. On the other hand, silencing RhoA lessened androgen-regulated cell viability and handicapped prostate cancer cell migration.
446:
423:
2096:(TGF)-mediated pathways that control tumor progression and identity are also frequently noted to be RhoA-dependent mechanisms. TGF-β1, a tumor suppressive growth factor, is known to regulate growth, differentiation and epithelial transformation in tumorigenesis. Instead of blocking growth, TGF-β1 directly activates RhoA in epithelial cells while blocking its downstream target, p160; as a result, activated RhoA-dependent pathways induce stress fiber formation and subsequent mesenchymal properties .
320:
345:
2364:
RhoA and Rho-kinase have become promising new target molecules for pharmacological research to develop alternate forms of treatment for asthma. RhoA and Rho kinase mechanisms have been linked to diabetes due to the up-regulated expression of targets within type 1 and 2 diabetic animals. Inhibition of this pathway prevented and ameliorated pathologic changes in diabetic complications, indicating that RhoA pathway is a promising target for therapeutic development in diabetes treatment
2139:, which effectively reorganizes the actin cytoskeleton of the cell. In the case of neurons, activation of this pathway results in growth cone collapse, therefore inhibits the growth and repair of neural pathways and axons. Inhibition of this pathway by its various components usually results in some level of improved re-myelination. After global ischemia, hyperbaric oxygen (at least at 3 ATA) appears to partially suppress expression of RhoA, in addition to Nogo protein (
5514:
2092:
intermediary switch within the overall mechanically mediated process of stem cell commitment and differentiation. For example, human mesenchymal stem cells and their differentiation into adipocytes or osteocytes are direct results of RhoA's impact on cell shape, signaling and cytoskeletal integrity. Cell shape acts as the primary mechanical cue that drives RhoA activity and downstream effector ROCK activity to control stem cell commitment and cytoskeletal maintenance.
5604:
5634:
5574:
5649:
711:
704:
697:
5559:
5664:
5529:
5589:
5694:
452:
351:
5499:
5709:
5679:
5544:
49:
2083:
signal transduction mediation is also attributed to the establishment of tissue polarity in epidermal structures due to its actin polymerization to coordinate vesicular motion; movement within actin filaments forms webs that move in conjunction with vesicular linear motion. As a result, mutations present in the polarity genes indicate that RhoA is critical for tissue polarity and directed intracellular movement.
5484:
5619:
2000:. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.
6922:
2355:
cancer. When tested on breast cancer cells, Rhosin inhibited growth and the growth of mammary spheres in a dose dependent manner, functioning as targets for RhoA while simultaneously maintaining the integrity of normal cellular processes and normal breast cells. These promising results indicate Rhosin's general effectiveness in preventing breast cancer proliferation via RhoA targeting.
2016:
Switch I and Switch II, whose conformational states are modified following the activation or inactivation of the protein. Both of these switches have characteristic folding, correspond to specific regions on the RhoA coil and are uniformly stabilized via hydrogen bonds. The conformations of the Switch domains are modified depending on the binding of either
2341:
invasion in upper urinary tract cancer. Although both RhoA and RhoC proteins comprise a significant part of the Rho GTPases that are linked to promoting the invasive behavior of breast carcinomas, attributing specific functions to these individual members has been difficult. We have used a stable retroviral
2354:
In June 2012, a new drug candidate named "Rhosin" was synthesized by researchers at the
Cincinnati Children's Hospital, a drug with the full intention to inhibit cancer proliferation and promote nerve cell regeneration. This inhibitor specifically targets Rho GTPases to prevent cell growth related to
2015:
Similar to other GTPases, RhoA presents a Rho insert in its primary sequence in the GTPase domain. RhoA contains also four insertion or deletion sites with an extra helical subdomain; these sites are characteristic of many GTPases in the Rho family. Most importantly, RhoA contains two switch regions,
2118:
and cyclin-dependent kinase inhibitors (p21 and p27) expression. These regulation pathways activate protein kinases, which subsequently modulate transcription factor activity. RhoA specifically suppresses p21 levels in normal and transformed cell lines via a p53-independent transcriptional mechanism
2082:
and Dia is essential for the regulation of cell polarity and organization of microtubules. RhoA also regulates the integrity of the extracellular matrix and the loss of corresponding cell-cell adhesions (primarily adherens and tight junctions) required for the migration of epithelial. RhoA's role in
2056:
and GTPase activating factor). RhoA is activated primarily by guanine nucleotide exchange factors (GEFs) via phosphorylation; due to large network of overlapping phosphorylation, a multitude of GEFs are utilized to enable specific signaling pathways. These structural arrangements provide interaction
2336:
RhoA has also been found to be hyper activated in gastric cancer cells; in consequence, suppression of RhoA activity partially reversed the proliferation phenotype of gastric cancer cells via the down-regulation of the RhoA-mammalian
Diaphanous 1 pathway. Doxorubicin has been referred to frequently
2104:
Activated RhoA also participates in regulating transcriptional control over other signal transduction pathways via various cellular factors. RhoA proteins help potentiate the transcription independent of ternary complex factors when activated while simultaneously modulating subsequent extracellular
2035:
Correct localization of the RhoA proteins is heavily dependent on the C-terminus; during prenylation, the anchoring of the prenyl group is essential for the stability, inhibition of and the synthesis of enzymes and proliferation. RhoA is sequestered by dissociation inhibitors (RhoGDIs) which remove
2363:
RhoA's physiological functions have been linked to the contraction and migration of cells which are manifested as symptoms in both asthma and diabetes (i.e. airflow limitation and hyper-responsiveness, desensitization, etc.). Due to pathophysiological overlap of RhoA and Rho-kinase in asthma, both
2345:
approach to generate invasive breast carcinoma cells (SUM-159 cells) that lack either RhoA or RhoC expression. Analysis of these cells enabled us to deduce that RhoA impedes and RhoC stimulates invasion. Unexpectedly, this analysis also revealed a compensatory relationship between RhoA and RhoC at
2340:
Protein expression of RhoA has been identified to be significantly higher in testicular tumor tissue than that in nontumor tissue; expression of protein for RhoA, ROCK-I, ROCK-II, Rac1, and Cdc42 was greater in tumors of higher stages than lower stages, coinciding with greater lymph metastasis and
2332:
Given that its overexpression is found in many malignancies, RhoA activity has been linked within several cancer applications due to its significant involvement in cancer signaling cascades. Serum response factors (SRFs) are known to mediate androgen receptors in prostate cancer cells, including
2091:
RhoA is required for processes involving cell development, some of which include outgrowth, dorsal closure, bone formation, and myogenesis. Loss of RhoA function is frequently attributed to failed gastrulation and cell migration inability. In extension, RhoA has been shown to function as an
75:
2057:
sites that can interact with effectors and guanine factors in order to stabilize and signal the hydrolysis of GTP. Activation levels of RhoA and associated GEFs are measured using RhoA and GEF pull down assays that uses
Rhotekin and mutant RhoA G17A beads respectively
2143:), and a subunit of its receptor Ng-R. The MEMO1-RhoA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. A recent study shows that RhoA-Rho kinase signaling mediates thrombin-induced brain damage.
2032:, anchoring the GTPase into membranes, which is essential for its role in cell growth and cytoskeleton organization. Key amino acids that are involved in the stabilization and regulation of GTP hydrolysis are conserved in RhoA as Gly14, Thr19, Phe30 and Gln63.
2113:
RhoA as well as several other members of the Rho family are identified as having roles in the regulation of the cytoskeleton and cell division. RhoA plays a pivotal role in G1 cell cycle progression, primarily through regulation of
2073:
RhoA is prevalent in regulating cell shape, polarity and locomotion via actin polymerization, actomyosin contractility, cell adhesion, and microtubule dynamics. In addition, RhoA is believed to act primarily at the rear
2461:
Kiss C, Li J, Szeles A, Gizatullin RZ, Kashuba VI, Lushnikova T, et al. (1997). "Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization and with somatic cell hybrids".
2027:
The primary protein sequences of members of the Rho family are mostly identical, with the N-terminal containing most of the protein coding for GTP binding and hydrolysis. The C-terminal of RhoA is modified via
2065:
RhoA is primarily involved in these activities: actin organization, myosin contractility, cell cycle maintenance, cellular morphological polarization, cellular development and transcriptional control.
2024:
to RhoA. The nature of the bound nucleotide and the ensuing conformational modification of the Switch domains dictates the ability of RhoA to bind or not with partner proteins (see below).
5513:
4027:
Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene".
3738:
Rümenapp U, Blomquist A, Schwörer G, Schablowski H, Psoma A, Jakobs KH (October 1999). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member".
2497:
Oliyarnyk O, Renner W, Paulweber B, Wascher TC (April 2005). "Interindividual differences of response to statin treatment cannot be explained by variations of the human gene for RhoA".
3042:
Karnezis T, Mandemakers W, McQualter JL, Zheng B, Ho PP, Jordan KA, et al. (July 2004). "The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination".
5603:
4075:"RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability"
5633:
5573:
3304:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
5749:
2166:
binding to p75NTR inhibits the association of RhoGDI and p75NTR, thereby suppressing RhoA release and promoting growth cone elongation (inhibiting RhoA actin suppression).
3085:
Bregman BS, Kunkel-Bagden E, Schnell L, Dai HN, Gao D, Schwab ME (November 1995). "Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors".
459:
358:
4819:"Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules"
3660:
Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (January 1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity".
5648:
2044:
RhoA acquires both inactive GDP-bound and active GTP-bound conformational states; these states alternate between the active and inactive states via the exchange of
4688:"Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7"
4198:
Hotta K, Tanaka K, Mino A, Kohno H, Takai Y (August 1996). "Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor".
2135:, TROY and other unknown receptors (e.g. by CSPGs), which stimulates RhoA. RhoA activates ROCK (RhoA kinase) which stimulates LIM kinase, which then inhibits
5558:
5383:
2150:
mobility and inhibits neuronal elongation in the developing nervous system. p75NTR without a ligand bound activates RhoA and limits actin assembly, but
1614:
281:
5663:
5528:
2132:
1595:
6442:
5742:
5588:
3136:
Zhou C, Li Y, Nanda A, Zhang JH (September 2003). "HBO suppresses Nogo-A, Ng-R, or RhoA expression in the cerebral cortex after global ischemia".
5972:
4372:"Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination"
2146:
p75NTR serves as a regulator for actin assembly. Ras homolog family member A (RhoA) causes the actin cytoskeleton to become rigid which limits
4770:"p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling"
5463:
2638:
2440:
72:
5941:
6942:
5693:
2422:
2012:, is located on chromosome 3 and consists of four exons, which has also been linked as a possible risk factor for atherothrombolic stroke.
5498:
4163:
Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10".
5708:
5678:
5543:
3572:"Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy"
2053:
445:
5735:
3355:
Zhang B, Zheng Y (April 1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1".
1893:
4506:"Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology"
1886:
6641:
422:
4868:"The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton"
6532:
5483:
2409:
2388:
1974:. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly
6527:
4602:
Genth H, Schmidt M, Gerhard R, Aktories K, Just I (February 2003). "Activation of phospholipase D1 by ADP-ribosylated RhoA".
2756:"Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism"
28:
6797:
2405:
344:
319:
6549:
2079:
6912:
2384:
6597:
5914:
5618:
1992:) are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the
261:
6519:
5390:
4958:"The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain"
2619:
Sajib MS, Zahra FT, Akwii RG, Mikelis CM (2021). "Identification of Rho GEF and RhoA Activation by Pull-Down Assays".
2175:
4421:"Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling"
3261:
Yamashita T, Tohyama M (May 2003). "The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI".
458:
357:
2093:
6782:
3392:"Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190"
6898:
6885:
6872:
6859:
6846:
6833:
6820:
6578:
6119:
6017:
5842:
5838:
5815:
5788:
5775:
5762:
5456:
5048:"RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors"
451:
350:
6792:
3703:
Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)".
3613:"Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding"
6746:
6689:
6133:
5828:
5793:
5766:
5377:
1659:
269:
4917:"Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase"
4555:"Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells"
3433:"Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA"
2854:"The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization"
6694:
6503:
6466:
5805:
4323:
Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazempour R, et al. (August 2002).
1640:
6233:
5873:
4419:
Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, et al. (November 1996).
4073:
Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, et al. (August 2003).
2049:
2021:
5263:
Zhou H, Li YJ (September 2010). "RhoA/Rho kinase: a novel therapeutic target in diabetic complications".
2662:
Strutt DI, Weber U, Mlodzik M (May 1997). "The role of RhoA in tissue polarity and
Frizzled signalling".
6715:
6634:
6363:
6271:
2045:
2036:
the protein from the membrane while preventing its further interaction with other downstream effectors.
2017:
1964:
6787:
2543:
Wheeler AP, Ridley AJ (November 2004). "Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility".
5449:
3794:
3472:
Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, et al. (July 2003).
3313:
3094:
2671:
1836:
333:
6751:
6568:
5522:: CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1
5087:
Doublier S, Riganti C, Voena C, Costamagna C, Aldieri E, Pescarmona G, et al. (October 2008).
2075:
1978:
stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them,
1865:
1861:
1828:
1818:
1814:
1810:
1806:
1802:
1782:
1778:
1749:
1739:
1735:
1731:
1727:
1723:
248:
5294:
Ramakers GJ (April 2002). "Rho proteins, mental retardation and the cellular basis of cognition".
1840:
6684:
6583:
6149:
5727:
5319:
4352:
4145:
4052:
3968:
3763:
3685:
3337:
3286:
3118:
3067:
3024:
2834:
2695:
2522:
293:
5179:
Shang X, Marchioni F, Sipes N, Evelyn CR, Jerabek-Willemsen M, Duhr S, et al. (June 2012).
1869:
1832:
1774:
1753:
1205:
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
5612:: Crystal structure of the complex between the human RhoA and Rho-binding domain of human ROCKI
4956:
Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M (November 2000).
3937:
Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S (December 1995).
6947:
5823:
5421:
5400:
5354:
5311:
5272:
5245:
5210:
5161:
5110:
5069:
5028:
4979:
4938:
4897:
4848:
4799:
4750:
4709:
4668:
4619:
4584:
4535:
4486:
4442:
4401:
4344:
4305:
4264:
4215:
4180:
4137:
4096:
4044:
4009:
3960:
3919:
3863:
3822:
3755:
3720:
3677:
3642:
3593:
3552:
3503:
3454:
3413:
3372:
3329:
3278:
3243:
3202:
3153:
3110:
3059:
3016:
2981:
2932:
2883:
2826:
2785:
2754:
Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, et al. (January 2001).
2736:
2687:
2644:
2634:
2601:
2560:
2514:
2479:
2284:
241:
65:
2154:
binding to p75NTR can inactivate RhoA and promote actin assembly. p75NTR associates with the
6730:
6725:
6699:
6627:
6213:
6159:
6141:
6007:
5997:
5951:
5344:
5303:
5237:
5200:
5192:
5151:
5141:
5100:
5059:
5018:
5010:
4969:
4928:
4887:
4879:
4838:
4830:
4789:
4781:
4768:
Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, et al. (July 2003).
4740:
4699:
4658:
4650:
4611:
4574:
4566:
4525:
4517:
4476:
4432:
4391:
4383:
4370:
Pearlman A, Loke J, Le
Caignec C, White S, Chin L, Friedman A, et al. (December 2010).
4336:
4295:
4254:
4246:
4207:
4172:
4127:
4086:
4036:
3999:
3950:
3909:
3901:
3853:
3812:
3802:
3747:
3712:
3669:
3632:
3624:
3583:
3542:
3534:
3493:
3485:
3444:
3403:
3364:
3321:
3270:
3233:
3192:
3184:
3145:
3102:
3051:
3008:
2971:
2963:
2922:
2914:
2873:
2865:
2816:
2775:
2767:
2726:
2679:
2624:
2591:
2552:
2506:
2471:
2342:
2278:
710:
703:
696:
538:
469:
413:
368:
6026:
5642:: Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA
4729:"SmgGDS displays differential binding and exchange activity towards different Ras isoforms"
3783:"Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF"
2999:
Bradbury EJ, McMahon SB (August 2006). "Spinal cord repair strategies: why do they work?".
2805:"The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF"
2580:"Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue"
6777:
6761:
6674:
6560:
6449:
6263:
5963:
5783:
5582:: Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA
5394:
2578:
Ihara K, Muraguchi S, Kato M, Shimizu T, Shirakawa M, Kuroda S, et al. (April 1998).
1993:
513:
289:
1360:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
5373:
4465:"Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif"
3798:
3317:
3098:
2675:
6926:
6815:
6756:
5883:
5205:
5180:
5156:
5129:
5023:
4998:
4817:
Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, et al. (December 2002).
4663:
4638:
4579:
4554:
4530:
4505:
4396:
4371:
3637:
3612:
3547:
3522:
3498:
3473:
3197:
3172:
2976:
2951:
2927:
2902:
2878:
2853:
5307:
4997:
Schmidt LJ, Duncan K, Yadav N, Regan KM, Verone AR, Lohse CM, et al. (May 2012).
4892:
4867:
4843:
4818:
4794:
4769:
4615:
4504:
Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (June 1997).
4132:
4115:
3914:
3889:
3817:
3782:
3751:
3716:
3673:
3611:
Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR (January 2001).
3489:
3238:
3222:"Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth"
3221:
2821:
2804:
2731:
2714:
1529:
1524:
1519:
1514:
1509:
1504:
1499:
1494:
1489:
1484:
1479:
1474:
1469:
1464:
1459:
1454:
1449:
1444:
1439:
1434:
1429:
1424:
1419:
1414:
1409:
1404:
1399:
1394:
1389:
1384:
1379:
1374:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
792:
787:
782:
777:
772:
767:
762:
757:
752:
48:
6936:
6720:
6679:
6427:
6037:
5430:
5409:
4834:
4259:
4250:
4234:
3955:
3938:
3905:
3173:"Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury"
2780:
2755:
1997:
739:
5323:
4999:"RhoA as a mediator of clinically relevant androgen action in prostate cancer cells"
4356:
4149:
4116:"The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel"
4056:
3972:
3689:
3290:
3028:
2838:
2526:
273:
6669:
6412:
6385:
6314:
6307:
6290:
6285:
6259:
5196:
5181:"Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases"
3986:
Houssa B, de Widt J, Kranenburg O, Moolenaar WH, van
Blitterswijk WJ (March 1999).
3767:
3341:
3122:
3071:
2699:
2163:
2151:
1957:
531:
310:
5105:
5089:"RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells"
5088:
5064:
5047:
2715:"Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment"
1986:(Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in
3988:"Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA"
2629:
297:
6893:
6828:
6664:
6508:
3523:"Large-scale mapping of human protein-protein interactions by mass spectrometry"
2556:
2445:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2427:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2308:
2296:
2159:
2147:
2140:
2029:
6921:
5241:
4387:
3787:
Proceedings of the
National Academy of Sciences of the United States of America
3149:
1335:
negative regulation of intracellular steroid hormone receptor signaling pathway
614:
6493:
6182:
5349:
5332:
4040:
2510:
2219:
1988:
430:
327:
277:
5657:: Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF
4933:
4916:
4437:
4420:
4284:"RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity"
3408:
3391:
3188:
6867:
6841:
6199:
5758:
5146:
4785:
4704:
4687:
4235:"Kinectin is a key effector of RhoG microtubule-dependent cellular activity"
4004:
3987:
3842:"XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC"
3840:
Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (November 2002).
3807:
3449:
3432:
2596:
2579:
2115:
1559:
674:
552:
497:
484:
396:
383:
285:
5387:
5358:
5315:
5276:
5249:
5214:
5165:
5114:
5073:
5032:
4983:
4974:
4957:
4883:
4852:
4803:
4754:
4745:
4728:
4672:
4623:
4588:
4521:
4481:
4464:
4405:
4348:
4324:
4309:
4300:
4283:
4268:
4233:
Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P (December 2001).
4211:
4184:
4176:
4100:
4091:
4074:
4048:
4013:
3923:
3867:
3858:
3841:
3826:
3759:
3724:
3646:
3597:
3588:
3571:
3556:
3507:
3333:
3282:
3247:
3206:
3157:
3063:
3020:
2985:
2936:
2887:
2789:
2740:
2648:
2564:
2518:
4942:
4901:
4713:
4539:
4490:
4446:
4219:
4141:
3964:
3681:
3628:
3458:
3417:
3376:
3114:
2830:
2691:
2605:
2483:
1933:
1928:
5014:
3521:
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007).
2869:
2290:
2207:
2201:
1917:
1704:
1685:
5046:
Zhang S, Tang Q, Xu F, Xue Y, Zhen Z, Deng Y, et al. (April 2009).
4915:
Fujisawa K, Fujita A, Ishizaki T, Saito Y, Narumiya S (September 1996).
3325:
2771:
1060:
negative regulation of cell migration involved in sprouting angiogenesis
6604:
6573:
6351:
6346:
6105:
6095:
6070:
6065:
5800:
5435:
5425:
5414:
5404:
4570:
3538:
2918:
2213:
2195:
2189:
2183:
2155:
2136:
1960:
1671:
1626:
4654:
4340:
3368:
2475:
1505:
positive regulation of leukocyte adhesion to vascular endothelial cell
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
6880:
6650:
6481:
6123:
6100:
6090:
6060:
6055:
6050:
6045:
6002:
5992:
5987:
5982:
5977:
5946:
5934:
5929:
5924:
5919:
5907:
5902:
5897:
5846:
3474:"Rnd proteins function as RhoA antagonists by activating p190 RhoGAP"
3106:
2713:
McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS (April 2004).
2683:
2260:
2230:
2128:
1983:
1901:
1581:
5567:: Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L)
5228:
Kume H (2008). "RhoA/Rho-kinase as a therapeutic target in asthma".
4463:
Flynn P, Mellor H, Palmer R, Panayotou G, Parker PJ (January 1998).
3171:
Han X, Lan X, Li Q, Gao Y, Zhu W, Cheng T, et al. (June 2016).
3012:
2967:
1500:
positive regulation of vascular associated smooth muscle contraction
17:
3274:
3055:
1495:
negative regulation of reactive oxygen species biosynthetic process
6854:
6537:
6476:
6459:
6454:
6302:
6280:
6246:
6241:
6226:
6204:
6192:
6187:
6177:
6172:
6167:
5892:
5868:
2314:
2302:
2272:
2248:
2242:
1979:
1975:
4639:"Determination of interaction sites of phospholipase D1 for RhoA"
2623:. Methods in Molecular Biology. Vol. 2193. pp. 97–109.
1544:
1540:
252:, ARH12, ARHA, RHO12, RHOH12, ras homolog family member A, EDFAOB
6542:
6498:
6486:
6471:
6437:
6432:
6417:
6400:
6395:
6390:
6378:
6373:
6368:
6358:
6334:
6329:
6324:
6319:
6221:
5672:: Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
5537:: CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP
4282:
Gallagher ED, Gutowski S, Sternweis PC, Cobb MH (January 2004).
2903:"Dynamic functions of RhoA in tumor cell migration and invasion"
2266:
2254:
2236:
2224:
1996:, a family of proteins involved in the regulation and timing of
1971:
265:
6623:
5731:
5445:
1065:
positive regulation of protein serine/threonine kinase activity
6592:
6588:
5441:
1982:(Rho-associated, coiled-coil containing protein kinase 1) and
719:
4686:
Alberts AS, Bouquin N, Johnston LH, Treisman R (April 1998).
4553:
Thodeti CK, Massoumi R, Bindslev L, Sjölander A (July 2002).
1515:
regulation of modification of postsynaptic actin cytoskeleton
1085:
vascular endothelial growth factor receptor signaling pathway
5420:
Overview of all the structural information available in the
5399:
Overview of all the structural information available in the
1215:
regulation of systemic arterial blood pressure by endothelin
5597:: Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP
3888:
Riento K, Guasch RM, Garg R, Jin B, Ridley AJ (June 2003).
1325:
establishment or maintenance of actin cytoskeleton polarity
6619:
2162:
can strengthen the association between p75NTR and RhoGDI.
1350:
negative regulation of I-kappaB kinase/NF-kappaB signaling
1130:
transforming growth factor beta receptor signaling pathway
1110:
positive regulation of I-kappaB kinase/NF-kappaB signaling
849:
extrinsic component of cytoplasmic side of plasma membrane
5130:"RhoA: a therapeutic target for chronic myeloid leukemia"
4325:"p115 Rho GTPase activating protein interacts with MEKK1"
3939:"A novel partner for the GTP-bound forms of rho and rac"
3890:"RhoE binds to ROCK I and inhibits downstream signaling"
1425:
positive regulation of alpha-beta T cell differentiation
521:
5128:
Molli PR, Pradhan MB, Advani SH, Naik NR (March 2012).
3781:
Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003).
1125:
regulation of small GTPase mediated signal transduction
2158:, and RhoGDI associates with RhoA. Interactions with
1380:
establishment of epithelial cell apical/basal polarity
1255:
regulation of actin polymerization or depolymerization
27:"RHOA" redirects here. For the television series, see
6910:
686:
5702:: Crystal structure of the human RhoC-GppNHp complex
1320:
positive regulation of actin filament polymerization
1285:
negative regulation of neuron projection development
6806:
6770:
6739:
6708:
6657:
6558:
6517:
6257:
6131:
6118:
6083:
6035:
6016:
5962:
5882:
5861:
5854:
5837:
5814:
5774:
5333:"RhoA signaling in phorbol ester-induced apoptosis"
4604:
Biochemical and Biophysical Research Communications
4200:
Biochemical and Biophysical Research Communications
4165:
Biochemical and Biophysical Research Communications
3138:
Biochemical and Biophysical Research Communications
1854:
1801:
1767:
1722:
1465:
regulation of microtubule cytoskeleton organization
1180:
Wnt signaling pathway, planar cell polarity pathway
5507:: CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX
4866:Leung T, Chen XQ, Manser E, Lim L (October 1996).
3220:Yamashita T, Tucker KL, Barde YA (November 1999).
2401:
2399:
2397:
2380:
2378:
2376:
2127:Molecules act on various receptors, such as NgR1,
5717:: Crystal structure of the human RhoC-GSP complex
5687:: Crystal structure of the human RhoC-GDP complex
5552:: CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX
4114:Cachero TG, Morielli AD, Peralta EG (June 1998).
1525:regulation of neural precursor cell proliferation
1330:stress-activated protein kinase signaling cascade
468:
367:
1510:regulation of modification of synaptic structure
1485:negative regulation of oxidative phosphorylation
1415:positive regulation of smooth muscle contraction
1220:regulation of transcription by RNA polymerase II
4068:
4066:
3883:
3881:
3879:
3877:
1375:positive regulation of neuron apoptotic process
1370:negative regulation of neuron apoptotic process
4458:
4456:
4029:Naunyn-Schmiedeberg's Archives of Pharmacology
2538:
2536:
2406:GRCm38: Ensembl release 89: ENSMUSG00000007815
1490:positive regulation of NIK/NF-kappaB signaling
1275:negative regulation of cell-substrate adhesion
6635:
5743:
5457:
3177:Journal of Cerebral Blood Flow and Metabolism
2456:
2454:
2359:Possible target for asthma and diabetes drugs
1390:negative regulation of neuron differentiation
1100:positive regulation of neuron differentiation
995:regulation of actin cytoskeleton organization
980:apolipoprotein A-I-mediated signaling pathway
8:
1245:G protein-coupled receptor signaling pathway
1155:positive regulation of stress fiber assembly
4727:Vikis HG, Stewart S, Guan KL (April 2002).
3431:Zhang B, Chernoff J, Zheng Y (April 1998).
2952:"Glial inhibition of CNS axon regeneration"
2385:GRCh38: Ensembl release 89: ENSG00000067560
1295:forebrain radial glial cell differentiation
1280:regulation of neuron projection development
6642:
6628:
6620:
6128:
5858:
5851:
5750:
5736:
5728:
5464:
5450:
5442:
2803:Hill CS, Wynne J, Treisman R (June 1995).
1798:
1719:
1555:
735:
509:
408:
305:
83:
5434:(Mouse Transforming protein RhoA) at the
5413:(Human Transforming protein RhoA) at the
5376:at the U.S. National Library of Medicine
5348:
5204:
5155:
5145:
5104:
5063:
5022:
4973:
4932:
4891:
4842:
4793:
4744:
4703:
4662:
4578:
4529:
4480:
4436:
4395:
4299:
4258:
4131:
4090:
4003:
3954:
3913:
3857:
3816:
3806:
3636:
3587:
3546:
3497:
3448:
3407:
3237:
3196:
2975:
2926:
2877:
2820:
2779:
2730:
2628:
2595:
1170:small GTPase mediated signal transduction
5492:: HUMAN RHOA COMPLEXED WITH GTP ANALOGUE
3390:Li R, Zhang B, Zheng Y (December 1997).
1480:positive regulation of podosome assembly
1090:skeletal muscle satellite cell migration
975:ossification involved in bone maturation
939:intracellular membrane-bounded organelle
6917:
5479:
2372:
2156:Rho GDP dissociation inhibitor (RhoGDI)
1530:positive regulation of T cell migration
1470:cellular response to lipopolysaccharide
1410:positive regulation of vasoconstriction
1165:phosphatidylinositol-mediated signaling
1475:cellular response to cytokine stimulus
1040:regulation of osteoblast proliferation
1035:positive regulation of lipase activity
793:Rho GDP-dissociation inhibitor binding
38:
2008:The specific gene that encodes RhoA,
1450:regulation of focal adhesion assembly
1310:positive regulation of cell migration
473:
434:
429:
372:
331:
326:
7:
3570:Gajate C, Mollinedo F (March 2005).
1400:positive regulation of cell adhesion
1210:alpha-beta T cell lineage commitment
4962:The Journal of Biological Chemistry
4921:The Journal of Biological Chemistry
4692:The Journal of Biological Chemistry
4469:The Journal of Biological Chemistry
4425:The Journal of Biological Chemistry
4288:The Journal of Biological Chemistry
4079:The Journal of Biological Chemistry
3992:The Journal of Biological Chemistry
3846:The Journal of Biological Chemistry
3576:The Journal of Biological Chemistry
3437:The Journal of Biological Chemistry
3396:The Journal of Biological Chemistry
2584:The Journal of Biological Chemistry
2061:Participation in cellular processes
2054:guanine nucleotide exchange factors
1455:regulation of calcium ion transport
1315:androgen receptor signaling pathway
1080:negative regulation of axonogenesis
1025:positive regulation of axonogenesis
4376:American Journal of Human Genetics
2852:Kumar D, Lassar AB (August 2009).
1851:
1764:
1695:
1676:
1650:
1631:
1605:
1586:
1435:regulation of dendrite development
1395:positive regulation of translation
1305:positive regulation of cell growth
1250:skeletal muscle tissue development
1050:positive regulation of cytokinesis
954:intracellular anatomical structure
691:
609:
547:
526:
25:
5627:: RHO/RHOGAP/GDP(DOT)ALF4 COMPLEX
1967:that in humans is encoded by the
1460:negative regulation of cell death
1145:wound healing, spreading of cells
1070:mitotic cleavage furrow formation
1010:ephrin receptor signaling pathway
970:actin cytoskeleton reorganization
36:Protein and coding gene in humans
6920:
5707:
5692:
5677:
5662:
5647:
5632:
5617:
5602:
5587:
5572:
5557:
5542:
5527:
5512:
5497:
5482:
4835:10.1128/mcb.22.24.8721-8734.2002
4251:10.1128/MCB.21.23.8022-8034.2001
3906:10.1128/mcb.23.12.4219-4229.2003
1405:negative regulation of cell size
1015:endothelial tube lumen extension
709:
702:
695:
457:
450:
444:
421:
356:
349:
343:
318:
47:
5331:Chang ZF, Lee HH (March 2006).
1430:neuron projection morphogenesis
1265:response to mechanical stimulus
1160:actin cytoskeleton organization
1105:Rho protein signal transduction
909:ficolin-1-rich granule membrane
788:protein domain specific binding
5197:10.1016/j.chembiol.2012.05.009
4872:Molecular and Cellular Biology
4823:Molecular and Cellular Biology
4329:Journal of Cellular Physiology
4239:Molecular and Cellular Biology
3894:Molecular and Cellular Biology
2858:Molecular and Cellular Biology
2464:Cytogenetics and Cell Genetics
2052:(conducted simultaneously via
1520:cellular response to chemokine
1440:actin filament bundle assembly
1290:cerebral cortex cell migration
834:endoplasmic reticulum membrane
720:More reference expression data
675:More reference expression data
30:The Real Housewives of Atlanta
1:
5337:Journal of Biomedical Science
5308:10.1016/S0166-2236(00)02118-4
5106:10.1158/1541-7786.MCR-08-0251
5065:10.1158/1541-7786.MCR-08-0248
4774:Molecular Biology of the Cell
4616:10.1016/s0006-291x(03)00112-8
4133:10.1016/s0092-8674(00)81212-x
3752:10.1016/s0014-5793(99)01270-3
3717:10.1016/s0300-9084(01)01263-9
3674:10.1016/s0014-5793(98)00020-9
3490:10.1016/s0960-9822(03)00418-4
3239:10.1016/s0896-6273(00)81114-9
2822:10.1016/S0092-8674(05)80020-0
2760:Molecular Biology of the Cell
2732:10.1016/S1534-5807(04)00075-9
442:
341:
4637:Cai S, Exton JH (May 2001).
3956:10.1016/0014-5793(95)01351-2
3001:Nature Reviews. Neuroscience
2956:Nature Reviews. Neuroscience
2630:10.1007/978-1-0716-0845-6_10
1020:Roundabout signaling pathway
1005:substantia nigra development
985:regulation of cell migration
6943:Genes on human chromosome 3
6520:Protein-synthesizing GTPase
5230:Current Medicinal Chemistry
4510:The Journal of Cell Biology
3617:The Journal of Cell Biology
2950:Yiu G, He Z (August 2006).
2901:O'Connor K, Chen M (2013).
2557:10.1016/j.yexcr.2004.08.012
1950:Ras homolog family member A
1230:actin filament organization
1175:regulation of cell motility
6964:
5242:10.2174/092986708786242831
4388:10.1016/j.ajhg.2010.11.003
3150:10.1016/j.bbrc.2003.08.006
2545:Experimental Cell Research
2094:Transforming growth factor
1445:response to glucocorticoid
1150:endothelial cell migration
904:secretory granule membrane
26:
6798:Michaelis–Menten kinetics
6579:Guanylate-binding protein
5763:acid anhydride hydrolases
5477:
5350:10.1007/s11373-005-9056-4
5093:Molecular Cancer Research
5052:Molecular Cancer Research
4041:10.1007/s00210-004-0926-5
3527:Molecular Systems Biology
2511:10.1007/s10528-005-1507-0
2441:"Mouse PubMed Reference:"
2423:"Human PubMed Reference:"
1946:Transforming protein RhoA
1932:
1927:
1923:
1916:
1900:
1894:Chr 9: 108.18 – 108.22 Mb
1881:
1858:
1825:
1794:
1771:
1746:
1715:
1702:
1698:
1683:
1679:
1670:
1657:
1653:
1638:
1634:
1625:
1612:
1608:
1593:
1589:
1580:
1565:
1558:
1554:
1538:
1225:cytoskeleton organization
1000:cleavage furrow formation
738:
734:
717:
694:
685:
672:
621:
612:
559:
550:
520:
512:
508:
491:
478:
441:
420:
411:
407:
390:
377:
340:
317:
308:
304:
259:
256:
246:
239:
234:
91:
86:
69:
64:
59:
55:
46:
41:
6690:Diffusion-limited enzyme
6134:Heterotrimeric G protein
5829:Phosphoadenylylsulfatase
5378:Medical Subject Headings
4934:10.1074/jbc.271.38.23022
4438:10.1074/jbc.271.46.28772
3409:10.1074/jbc.272.52.32830
3189:10.1177/0271678X15606462
1260:regulation of cell shape
1190:neutrophil degranulation
1185:protein deubiquitination
1140:apical junction assembly
1075:mitotic spindle assembly
5806:Thiamine-triphosphatase
5386:Info with links in the
5296:Trends in Neurosciences
5265:Chinese Medical Journal
5185:Chemistry & Biology
5147:10.1186/1476-4598-11-16
5003:Molecular Endocrinology
4786:10.1091/mbc.E02-09-0623
4705:10.1074/jbc.273.15.8616
4643:The Biochemical Journal
4559:The Biochemical Journal
4005:10.1074/jbc.274.11.6820
3808:10.1073/pnas.0234057100
3450:10.1074/jbc.273.15.8776
2597:10.1074/jbc.273.16.9656
2174:RHOA has been shown to
2100:Transcriptional control
1887:Chr 3: 49.36 – 49.41 Mb
1095:trabecula morphogenesis
884:apical junction complex
5388:Cell Migration Gateway
4975:10.1074/jbc.M003775200
4884:10.1128/mcb.16.10.5313
4746:10.1038/sj.onc.1205306
4522:10.1083/jcb.137.7.1603
4482:10.1074/jbc.273.5.2698
4301:10.1074/jbc.M309525200
4212:10.1006/bbrc.1996.1132
4177:10.1006/bbrc.2000.4160
4092:10.1074/jbc.M302401200
3859:10.1074/jbc.M207401200
3589:10.1074/jbc.M411781200
2109:Cell cycle maintenance
1355:response to amino acid
1340:cell junction assembly
783:protein kinase binding
6783:Eadie–Hofstee diagram
6716:Allosteric regulation
6561:Polymerization motors
6272:Rho family of GTPases
3629:10.1083/jcb.152.1.111
2323:Clinical significance
1965:Rho family of GTPases
1420:GTP metabolic process
1030:stress fiber assembly
949:glutamatergic synapse
889:extracellular exosome
661:stroma of bone marrow
6793:Lineweaver–Burk plot
5015:10.1210/me.2011-1130
2870:10.1128/MCB.01779-08
2499:Biochemical Genetics
2040:Activation mechanism
1300:cell differentiation
1240:cell-matrix adhesion
599:left coronary artery
436:Chromosome 9 (mouse)
334:Chromosome 3 (human)
87:List of PDB id codes
60:Available structures
6569:dynamin superfamily
3799:2003PNAS..100..733S
3326:10.1038/nature04209
3318:2005Natur.437.1173R
3263:Nature Neuroscience
3099:1995Natur.378..498B
3044:Nature Neuroscience
2772:10.1091/mbc.12.1.27
2676:1997Natur.387..292S
1385:response to ethanol
1270:response to glucose
1200:response to hypoxia
1055:platelet activation
990:negative chemotaxis
6752:Enzyme superfamily
6685:Enzyme promiscuity
5393:2014-12-11 at the
4571:10.1042/BJ20020248
3539:10.1038/msb4100134
2919:10.4161/sgtp.25131
2719:Developmental Cell
2621:Wound Regeneration
2069:Actin organization
1660:ENSMUSG00000007815
1195:cell morphogenesis
963:Biological process
924:cell division site
802:Cellular component
753:nucleotide binding
746:Molecular function
6908:
6907:
6617:
6616:
6613:
6612:
6114:
6113:
6079:
6078:
5824:Adenylylsulfatase
5725:
5724:
4655:10.1042/bj3550779
4341:10.1002/jcp.10125
4085:(35): 33492–500.
3369:10.1021/bi9718447
3093:(6556): 498–501.
2640:978-1-0716-0844-9
2476:10.1159/000134729
2350:Drug applications
2285:Protein kinase N1
1943:
1942:
1939:
1938:
1912:
1911:
1877:
1876:
1848:
1847:
1790:
1789:
1761:
1760:
1711:
1710:
1692:
1691:
1666:
1665:
1647:
1646:
1621:
1620:
1602:
1601:
1550:
1549:
730:
729:
726:
725:
681:
680:
668:
667:
606:
605:
504:
503:
403:
402:
230:
229:
226:
225:
70:Ortholog search:
16:(Redirected from
6955:
6925:
6924:
6916:
6788:Hanes–Woolf plot
6731:Enzyme activator
6726:Enzyme inhibitor
6700:Enzyme catalysis
6644:
6637:
6630:
6621:
6129:
5859:
5852:
5752:
5745:
5738:
5729:
5711:
5696:
5681:
5666:
5651:
5636:
5621:
5606:
5591:
5576:
5561:
5546:
5531:
5516:
5501:
5486:
5466:
5459:
5452:
5443:
5362:
5352:
5327:
5281:
5280:
5260:
5254:
5253:
5225:
5219:
5218:
5208:
5176:
5170:
5169:
5159:
5149:
5134:Molecular Cancer
5125:
5119:
5118:
5108:
5084:
5078:
5077:
5067:
5043:
5037:
5036:
5026:
4994:
4988:
4987:
4977:
4968:(46): 36116–23.
4953:
4947:
4946:
4936:
4912:
4906:
4905:
4895:
4863:
4857:
4856:
4846:
4814:
4808:
4807:
4797:
4765:
4759:
4758:
4748:
4724:
4718:
4717:
4707:
4683:
4677:
4676:
4666:
4649:(Pt 3): 779–85.
4634:
4628:
4627:
4599:
4593:
4592:
4582:
4565:(Pt 1): 157–63.
4550:
4544:
4543:
4533:
4501:
4495:
4494:
4484:
4460:
4451:
4450:
4440:
4416:
4410:
4409:
4399:
4367:
4361:
4360:
4320:
4314:
4313:
4303:
4279:
4273:
4272:
4262:
4230:
4224:
4223:
4195:
4189:
4188:
4160:
4154:
4153:
4135:
4111:
4105:
4104:
4094:
4070:
4061:
4060:
4024:
4018:
4017:
4007:
3983:
3977:
3976:
3958:
3934:
3928:
3927:
3917:
3885:
3872:
3871:
3861:
3852:(45): 42964–72.
3837:
3831:
3830:
3820:
3810:
3778:
3772:
3771:
3735:
3729:
3728:
3700:
3694:
3693:
3657:
3651:
3650:
3640:
3608:
3602:
3601:
3591:
3567:
3561:
3560:
3550:
3518:
3512:
3511:
3501:
3469:
3463:
3462:
3452:
3428:
3422:
3421:
3411:
3387:
3381:
3380:
3352:
3346:
3345:
3312:(7062): 1173–8.
3301:
3295:
3294:
3258:
3252:
3251:
3241:
3217:
3211:
3210:
3200:
3168:
3162:
3161:
3133:
3127:
3126:
3107:10.1038/378498a0
3082:
3076:
3075:
3039:
3033:
3032:
2996:
2990:
2989:
2979:
2947:
2941:
2940:
2930:
2898:
2892:
2891:
2881:
2849:
2843:
2842:
2824:
2800:
2794:
2793:
2783:
2751:
2745:
2744:
2734:
2710:
2704:
2703:
2684:10.1038/387292a0
2659:
2653:
2652:
2632:
2616:
2610:
2609:
2599:
2575:
2569:
2568:
2540:
2531:
2530:
2494:
2488:
2487:
2458:
2449:
2448:
2437:
2431:
2430:
2419:
2413:
2403:
2392:
2382:
2343:RNA interference
2279:Phospholipase D1
2087:Cell development
1948:, also known as
1925:
1924:
1896:
1889:
1872:
1852:
1843:
1799:
1795:RefSeq (protein)
1785:
1765:
1756:
1720:
1696:
1677:
1651:
1632:
1606:
1587:
1556:
736:
722:
713:
706:
699:
692:
677:
625:seminal vesicula
617:
615:Top expressed in
610:
571:popliteal artery
555:
553:Top expressed in
548:
527:
510:
500:
487:
476:
461:
454:
448:
437:
425:
409:
399:
386:
375:
360:
353:
347:
336:
322:
306:
300:
298:RHOA - orthologs
251:
244:
221:
84:
78:
57:
56:
51:
39:
21:
6963:
6962:
6958:
6957:
6956:
6954:
6953:
6952:
6933:
6932:
6931:
6919:
6911:
6909:
6904:
6816:Oxidoreductases
6802:
6778:Enzyme kinetics
6766:
6762:List of enzymes
6735:
6704:
6675:Catalytic triad
6653:
6648:
6618:
6609:
6554:
6513:
6264:Ras superfamily
6253:
6237:
6217:
6163:
6153:
6145:
6110:
6075:
6031:
6012:
5958:
5915:Plasma membrane
5878:
5833:
5810:
5784:Pyrophosphatase
5770:
5756:
5726:
5721:
5718:
5712:
5703:
5697:
5688:
5682:
5673:
5667:
5658:
5652:
5643:
5637:
5628:
5622:
5613:
5607:
5598:
5592:
5583:
5577:
5568:
5562:
5553:
5547:
5538:
5532:
5523:
5517:
5508:
5502:
5493:
5487:
5473:
5470:
5395:Wayback Machine
5370:
5365:
5330:
5293:
5289:
5287:Further reading
5284:
5262:
5261:
5257:
5236:(27): 2876–85.
5227:
5226:
5222:
5178:
5177:
5173:
5127:
5126:
5122:
5099:(10): 1607–20.
5086:
5085:
5081:
5045:
5044:
5040:
4996:
4995:
4991:
4955:
4954:
4950:
4927:(38): 23022–8.
4914:
4913:
4909:
4878:(10): 5313–27.
4865:
4864:
4860:
4829:(24): 8721–34.
4816:
4815:
4811:
4767:
4766:
4762:
4739:(15): 2425–32.
4726:
4725:
4721:
4698:(15): 8616–22.
4685:
4684:
4680:
4636:
4635:
4631:
4601:
4600:
4596:
4552:
4551:
4547:
4503:
4502:
4498:
4475:(5): 2698–705.
4462:
4461:
4454:
4431:(46): 28772–6.
4418:
4417:
4413:
4369:
4368:
4364:
4322:
4321:
4317:
4281:
4280:
4276:
4245:(23): 8022–34.
4232:
4231:
4227:
4197:
4196:
4192:
4162:
4161:
4157:
4113:
4112:
4108:
4072:
4071:
4064:
4026:
4025:
4021:
3985:
3984:
3980:
3936:
3935:
3931:
3900:(12): 4219–29.
3887:
3886:
3875:
3839:
3838:
3834:
3780:
3779:
3775:
3737:
3736:
3732:
3702:
3701:
3697:
3659:
3658:
3654:
3610:
3609:
3605:
3582:(12): 11641–7.
3569:
3568:
3564:
3520:
3519:
3515:
3484:(13): 1106–15.
3478:Current Biology
3471:
3470:
3466:
3443:(15): 8776–82.
3430:
3429:
3425:
3402:(52): 32830–5.
3389:
3388:
3384:
3363:(15): 5249–57.
3354:
3353:
3349:
3303:
3302:
3298:
3260:
3259:
3255:
3219:
3218:
3214:
3170:
3169:
3165:
3135:
3134:
3130:
3084:
3083:
3079:
3041:
3040:
3036:
3013:10.1038/nrn1964
2998:
2997:
2993:
2968:10.1038/nrn1956
2949:
2948:
2944:
2900:
2899:
2895:
2864:(15): 4262–73.
2851:
2850:
2846:
2802:
2801:
2797:
2753:
2752:
2748:
2712:
2711:
2707:
2670:(6630): 292–5.
2661:
2660:
2656:
2641:
2618:
2617:
2613:
2590:(16): 9656–66.
2577:
2576:
2572:
2542:
2541:
2534:
2496:
2495:
2491:
2470:(3–4): 228–30.
2460:
2459:
2452:
2439:
2438:
2434:
2421:
2420:
2416:
2404:
2395:
2383:
2374:
2370:
2361:
2352:
2330:
2325:
2320:
2172:
2125:
2111:
2102:
2089:
2071:
2063:
2042:
2006:
1994:Ras superfamily
1934:View/Edit Mouse
1929:View/Edit Human
1892:
1885:
1882:Location (UCSC)
1868:
1864:
1860:
1839:
1835:
1831:
1827:
1821:
1817:
1813:
1809:
1805:
1781:
1777:
1773:
1752:
1748:
1742:
1738:
1734:
1730:
1726:
1641:ENSG00000067560
1534:
958:
934:dendritic spine
929:ruffle membrane
874:cleavage furrow
854:plasma membrane
829:cell projection
797:
773:GTPase activity
768:protein binding
718:
708:
707:
701:
700:
673:
664:
659:
655:
651:
647:
643:
639:
635:
631:
629:ascending aorta
627:
613:
602:
597:
595:trabecular bone
593:
589:
585:
581:
577:
575:tibial arteries
573:
569:
565:
551:
495:
482:
474:
464:
463:
462:
455:
435:
412:Gene location (
394:
381:
373:
363:
362:
361:
354:
332:
309:Gene location (
260:
247:
240:
93:
71:
37:
34:
23:
22:
15:
12:
11:
5:
6961:
6959:
6951:
6950:
6945:
6935:
6934:
6930:
6929:
6906:
6905:
6903:
6902:
6889:
6876:
6863:
6850:
6837:
6824:
6810:
6808:
6804:
6803:
6801:
6800:
6795:
6790:
6785:
6780:
6774:
6772:
6768:
6767:
6765:
6764:
6759:
6754:
6749:
6743:
6741:
6740:Classification
6737:
6736:
6734:
6733:
6728:
6723:
6718:
6712:
6710:
6706:
6705:
6703:
6702:
6697:
6692:
6687:
6682:
6677:
6672:
6667:
6661:
6659:
6655:
6654:
6649:
6647:
6646:
6639:
6632:
6624:
6615:
6614:
6611:
6610:
6608:
6607:
6602:
6601:
6600:
6595:
6586:
6581:
6576:
6565:
6563:
6556:
6555:
6553:
6552:
6547:
6546:
6545:
6540:
6535:
6524:
6522:
6515:
6514:
6512:
6511:
6506:
6501:
6496:
6491:
6490:
6489:
6484:
6479:
6474:
6464:
6463:
6462:
6457:
6447:
6446:
6445:
6440:
6435:
6423:
6422:
6421:
6420:
6415:
6405:
6404:
6403:
6398:
6393:
6383:
6382:
6381:
6376:
6371:
6361:
6356:
6355:
6354:
6349:
6339:
6338:
6337:
6332:
6327:
6322:
6312:
6311:
6310:
6305:
6295:
6294:
6293:
6288:
6283:
6268:
6266:
6255:
6254:
6252:
6251:
6250:
6249:
6244:
6235:
6231:
6230:
6229:
6224:
6215:
6211:
6210:
6209:
6208:
6207:
6197:
6196:
6195:
6190:
6180:
6175:
6170:
6161:
6157:
6156:
6155:
6151:
6143:
6138:
6136:
6126:
6116:
6115:
6112:
6111:
6109:
6108:
6103:
6098:
6093:
6087:
6085:
6081:
6080:
6077:
6076:
6074:
6073:
6068:
6063:
6058:
6053:
6048:
6042:
6040:
6033:
6032:
6030:
6029:
6023:
6021:
6014:
6013:
6011:
6010:
6005:
6000:
5995:
5990:
5985:
5980:
5975:
5969:
5967:
5960:
5959:
5957:
5956:
5955:
5954:
5949:
5939:
5938:
5937:
5932:
5927:
5922:
5912:
5911:
5910:
5905:
5900:
5889:
5887:
5880:
5879:
5877:
5876:
5871:
5865:
5863:
5862:Cu++ (3.6.3.4)
5856:
5849:
5835:
5834:
5832:
5831:
5826:
5820:
5818:
5812:
5811:
5809:
5808:
5803:
5798:
5797:
5796:
5791:
5780:
5778:
5772:
5771:
5757:
5755:
5754:
5747:
5740:
5732:
5723:
5722:
5720:
5719:
5713:
5706:
5704:
5698:
5691:
5689:
5683:
5676:
5674:
5668:
5661:
5659:
5653:
5646:
5644:
5638:
5631:
5629:
5623:
5616:
5614:
5608:
5601:
5599:
5593:
5586:
5584:
5578:
5571:
5569:
5563:
5556:
5554:
5548:
5541:
5539:
5533:
5526:
5524:
5518:
5511:
5509:
5503:
5496:
5494:
5488:
5481:
5478:
5475:
5474:
5471:
5469:
5468:
5461:
5454:
5446:
5440:
5439:
5418:
5397:
5381:
5369:
5368:External links
5366:
5364:
5363:
5328:
5290:
5288:
5285:
5283:
5282:
5271:(17): 2461–6.
5255:
5220:
5191:(6): 699–710.
5171:
5120:
5079:
5038:
4989:
4948:
4907:
4858:
4809:
4780:(7): 2921–34.
4760:
4719:
4678:
4629:
4594:
4545:
4516:(7): 1603–13.
4496:
4452:
4411:
4382:(6): 898–904.
4362:
4315:
4274:
4225:
4190:
4155:
4126:(6): 1077–85.
4106:
4062:
4019:
3998:(11): 6820–2.
3978:
3929:
3873:
3832:
3773:
3730:
3695:
3652:
3603:
3562:
3513:
3464:
3423:
3382:
3347:
3296:
3275:10.1038/nn1045
3253:
3212:
3183:(6): 1059–74.
3163:
3128:
3077:
3056:10.1038/nn1261
3034:
2991:
2942:
2893:
2844:
2815:(7): 1159–70.
2795:
2746:
2705:
2654:
2639:
2611:
2570:
2532:
2505:(3–4): 143–8.
2489:
2450:
2432:
2414:
2393:
2371:
2369:
2366:
2360:
2357:
2351:
2348:
2329:
2326:
2324:
2321:
2319:
2318:
2312:
2306:
2300:
2294:
2288:
2282:
2276:
2270:
2264:
2258:
2252:
2246:
2240:
2234:
2228:
2222:
2217:
2211:
2205:
2199:
2193:
2187:
2180:
2171:
2168:
2124:
2121:
2110:
2107:
2101:
2098:
2088:
2085:
2070:
2067:
2062:
2059:
2041:
2038:
2005:
2002:
1941:
1940:
1937:
1936:
1931:
1921:
1920:
1914:
1913:
1910:
1909:
1907:
1905:
1898:
1897:
1890:
1883:
1879:
1878:
1875:
1874:
1856:
1855:
1849:
1846:
1845:
1837:NP_001300870.1
1823:
1822:
1796:
1792:
1791:
1788:
1787:
1769:
1768:
1762:
1759:
1758:
1744:
1743:
1717:
1713:
1712:
1709:
1708:
1700:
1699:
1693:
1690:
1689:
1681:
1680:
1674:
1668:
1667:
1664:
1663:
1655:
1654:
1648:
1645:
1644:
1636:
1635:
1629:
1623:
1622:
1619:
1618:
1610:
1609:
1603:
1600:
1599:
1591:
1590:
1584:
1578:
1577:
1572:
1567:
1563:
1562:
1552:
1551:
1548:
1547:
1536:
1535:
1533:
1532:
1527:
1522:
1517:
1512:
1507:
1502:
1497:
1492:
1487:
1482:
1477:
1472:
1467:
1462:
1457:
1452:
1447:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1387:
1382:
1377:
1372:
1367:
1365:beta selection
1362:
1357:
1352:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1312:
1307:
1302:
1297:
1292:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1135:cell migration
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
966:
964:
960:
959:
957:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
894:cell periphery
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
844:focal adhesion
841:
836:
831:
826:
821:
816:
811:
805:
803:
799:
798:
796:
795:
790:
785:
780:
775:
770:
765:
760:
758:myosin binding
755:
749:
747:
743:
742:
732:
731:
728:
727:
724:
723:
715:
714:
689:
683:
682:
679:
678:
670:
669:
666:
665:
663:
662:
658:
654:
650:
646:
642:
641:left lung lobe
638:
634:
630:
626:
622:
619:
618:
607:
604:
603:
601:
600:
596:
592:
588:
584:
580:
579:synovial joint
576:
572:
568:
564:
560:
557:
556:
544:
543:
535:
524:
518:
517:
514:RNA expression
506:
505:
502:
501:
493:
489:
488:
480:
477:
472:
466:
465:
456:
449:
443:
439:
438:
433:
427:
426:
418:
417:
405:
404:
401:
400:
392:
388:
387:
379:
376:
371:
365:
364:
355:
348:
342:
338:
337:
330:
324:
323:
315:
314:
302:
301:
258:
254:
253:
245:
237:
236:
232:
231:
228:
227:
224:
223:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
35:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6960:
6949:
6946:
6944:
6941:
6940:
6938:
6928:
6923:
6918:
6914:
6900:
6896:
6895:
6890:
6887:
6883:
6882:
6877:
6874:
6870:
6869:
6864:
6861:
6857:
6856:
6851:
6848:
6844:
6843:
6838:
6835:
6831:
6830:
6825:
6822:
6818:
6817:
6812:
6811:
6809:
6805:
6799:
6796:
6794:
6791:
6789:
6786:
6784:
6781:
6779:
6776:
6775:
6773:
6769:
6763:
6760:
6758:
6757:Enzyme family
6755:
6753:
6750:
6748:
6745:
6744:
6742:
6738:
6732:
6729:
6727:
6724:
6722:
6721:Cooperativity
6719:
6717:
6714:
6713:
6711:
6707:
6701:
6698:
6696:
6693:
6691:
6688:
6686:
6683:
6681:
6680:Oxyanion hole
6678:
6676:
6673:
6671:
6668:
6666:
6663:
6662:
6660:
6656:
6652:
6645:
6640:
6638:
6633:
6631:
6626:
6625:
6622:
6606:
6603:
6599:
6596:
6594:
6590:
6587:
6585:
6582:
6580:
6577:
6575:
6572:
6571:
6570:
6567:
6566:
6564:
6562:
6557:
6551:
6548:
6544:
6541:
6539:
6536:
6534:
6531:
6530:
6529:
6526:
6525:
6523:
6521:
6516:
6510:
6507:
6505:
6502:
6500:
6497:
6495:
6492:
6488:
6485:
6483:
6480:
6478:
6475:
6473:
6470:
6469:
6468:
6465:
6461:
6458:
6456:
6453:
6452:
6451:
6448:
6444:
6441:
6439:
6436:
6434:
6431:
6430:
6429:
6425:
6424:
6419:
6416:
6414:
6411:
6410:
6409:
6406:
6402:
6399:
6397:
6394:
6392:
6389:
6388:
6387:
6384:
6380:
6377:
6375:
6372:
6370:
6367:
6366:
6365:
6362:
6360:
6357:
6353:
6350:
6348:
6345:
6344:
6343:
6340:
6336:
6333:
6331:
6328:
6326:
6323:
6321:
6318:
6317:
6316:
6313:
6309:
6306:
6304:
6301:
6300:
6299:
6296:
6292:
6289:
6287:
6284:
6282:
6279:
6278:
6277:
6273:
6270:
6269:
6267:
6265:
6261:
6256:
6248:
6245:
6243:
6240:
6239:
6238:
6232:
6228:
6225:
6223:
6220:
6219:
6218:
6212:
6206:
6203:
6202:
6201:
6198:
6194:
6191:
6189:
6186:
6185:
6184:
6181:
6179:
6176:
6174:
6171:
6169:
6166:
6165:
6164:
6158:
6154:
6148:
6147:
6146:
6140:
6139:
6137:
6135:
6130:
6127:
6125:
6121:
6117:
6107:
6104:
6102:
6099:
6097:
6094:
6092:
6089:
6088:
6086:
6082:
6072:
6069:
6067:
6064:
6062:
6059:
6057:
6054:
6052:
6049:
6047:
6044:
6043:
6041:
6039:
6038:P-type ATPase
6034:
6028:
6025:
6024:
6022:
6019:
6015:
6009:
6006:
6004:
6001:
5999:
5996:
5994:
5991:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5970:
5968:
5965:
5961:
5953:
5950:
5948:
5945:
5944:
5943:
5940:
5936:
5933:
5931:
5928:
5926:
5923:
5921:
5918:
5917:
5916:
5913:
5909:
5906:
5904:
5901:
5899:
5896:
5895:
5894:
5891:
5890:
5888:
5885:
5881:
5875:
5872:
5870:
5867:
5866:
5864:
5860:
5857:
5853:
5850:
5848:
5844:
5840:
5836:
5830:
5827:
5825:
5822:
5821:
5819:
5817:
5813:
5807:
5804:
5802:
5799:
5795:
5792:
5790:
5787:
5786:
5785:
5782:
5781:
5779:
5777:
5773:
5768:
5764:
5760:
5753:
5748:
5746:
5741:
5739:
5734:
5733:
5730:
5716:
5710:
5705:
5701:
5695:
5690:
5686:
5680:
5675:
5671:
5665:
5660:
5656:
5650:
5645:
5641:
5635:
5630:
5626:
5620:
5615:
5611:
5605:
5600:
5596:
5590:
5585:
5581:
5575:
5570:
5566:
5560:
5555:
5551:
5545:
5540:
5536:
5530:
5525:
5521:
5515:
5510:
5506:
5500:
5495:
5491:
5485:
5480:
5476:
5467:
5462:
5460:
5455:
5453:
5448:
5447:
5444:
5437:
5433:
5432:
5427:
5423:
5419:
5416:
5412:
5411:
5406:
5402:
5398:
5396:
5392:
5389:
5385:
5382:
5379:
5375:
5372:
5371:
5367:
5360:
5356:
5351:
5346:
5343:(2): 173–80.
5342:
5338:
5334:
5329:
5325:
5321:
5317:
5313:
5309:
5305:
5301:
5297:
5292:
5291:
5286:
5278:
5274:
5270:
5266:
5259:
5256:
5251:
5247:
5243:
5239:
5235:
5231:
5224:
5221:
5216:
5212:
5207:
5202:
5198:
5194:
5190:
5186:
5182:
5175:
5172:
5167:
5163:
5158:
5153:
5148:
5143:
5139:
5135:
5131:
5124:
5121:
5116:
5112:
5107:
5102:
5098:
5094:
5090:
5083:
5080:
5075:
5071:
5066:
5061:
5058:(4): 570–80.
5057:
5053:
5049:
5042:
5039:
5034:
5030:
5025:
5020:
5016:
5012:
5009:(5): 716–35.
5008:
5004:
5000:
4993:
4990:
4985:
4981:
4976:
4971:
4967:
4963:
4959:
4952:
4949:
4944:
4940:
4935:
4930:
4926:
4922:
4918:
4911:
4908:
4903:
4899:
4894:
4889:
4885:
4881:
4877:
4873:
4869:
4862:
4859:
4854:
4850:
4845:
4840:
4836:
4832:
4828:
4824:
4820:
4813:
4810:
4805:
4801:
4796:
4791:
4787:
4783:
4779:
4775:
4771:
4764:
4761:
4756:
4752:
4747:
4742:
4738:
4734:
4730:
4723:
4720:
4715:
4711:
4706:
4701:
4697:
4693:
4689:
4682:
4679:
4674:
4670:
4665:
4660:
4656:
4652:
4648:
4644:
4640:
4633:
4630:
4625:
4621:
4617:
4613:
4610:(1): 127–32.
4609:
4605:
4598:
4595:
4590:
4586:
4581:
4576:
4572:
4568:
4564:
4560:
4556:
4549:
4546:
4541:
4537:
4532:
4527:
4523:
4519:
4515:
4511:
4507:
4500:
4497:
4492:
4488:
4483:
4478:
4474:
4470:
4466:
4459:
4457:
4453:
4448:
4444:
4439:
4434:
4430:
4426:
4422:
4415:
4412:
4407:
4403:
4398:
4393:
4389:
4385:
4381:
4377:
4373:
4366:
4363:
4358:
4354:
4350:
4346:
4342:
4338:
4334:
4330:
4326:
4319:
4316:
4311:
4307:
4302:
4297:
4294:(3): 1872–7.
4293:
4289:
4285:
4278:
4275:
4270:
4266:
4261:
4256:
4252:
4248:
4244:
4240:
4236:
4229:
4226:
4221:
4217:
4213:
4209:
4205:
4201:
4194:
4191:
4186:
4182:
4178:
4174:
4170:
4166:
4159:
4156:
4151:
4147:
4143:
4139:
4134:
4129:
4125:
4121:
4117:
4110:
4107:
4102:
4098:
4093:
4088:
4084:
4080:
4076:
4069:
4067:
4063:
4058:
4054:
4050:
4046:
4042:
4038:
4034:
4030:
4023:
4020:
4015:
4011:
4006:
4001:
3997:
3993:
3989:
3982:
3979:
3974:
3970:
3966:
3962:
3957:
3952:
3948:
3944:
3940:
3933:
3930:
3925:
3921:
3916:
3911:
3907:
3903:
3899:
3895:
3891:
3884:
3882:
3880:
3878:
3874:
3869:
3865:
3860:
3855:
3851:
3847:
3843:
3836:
3833:
3828:
3824:
3819:
3814:
3809:
3804:
3800:
3796:
3792:
3788:
3784:
3777:
3774:
3769:
3765:
3761:
3757:
3753:
3749:
3745:
3741:
3734:
3731:
3726:
3722:
3718:
3714:
3711:(5): 409–14.
3710:
3706:
3699:
3696:
3691:
3687:
3683:
3679:
3675:
3671:
3668:(2): 269–73.
3667:
3663:
3656:
3653:
3648:
3644:
3639:
3634:
3630:
3626:
3623:(1): 111–26.
3622:
3618:
3614:
3607:
3604:
3599:
3595:
3590:
3585:
3581:
3577:
3573:
3566:
3563:
3558:
3554:
3549:
3544:
3540:
3536:
3532:
3528:
3524:
3517:
3514:
3509:
3505:
3500:
3495:
3491:
3487:
3483:
3479:
3475:
3468:
3465:
3460:
3456:
3451:
3446:
3442:
3438:
3434:
3427:
3424:
3419:
3415:
3410:
3405:
3401:
3397:
3393:
3386:
3383:
3378:
3374:
3370:
3366:
3362:
3358:
3351:
3348:
3343:
3339:
3335:
3331:
3327:
3323:
3319:
3315:
3311:
3307:
3300:
3297:
3292:
3288:
3284:
3280:
3276:
3272:
3268:
3264:
3257:
3254:
3249:
3245:
3240:
3235:
3232:(3): 585–93.
3231:
3227:
3223:
3216:
3213:
3208:
3204:
3199:
3194:
3190:
3186:
3182:
3178:
3174:
3167:
3164:
3159:
3155:
3151:
3147:
3144:(2): 368–76.
3143:
3139:
3132:
3129:
3124:
3120:
3116:
3112:
3108:
3104:
3100:
3096:
3092:
3088:
3081:
3078:
3073:
3069:
3065:
3061:
3057:
3053:
3050:(7): 736–44.
3049:
3045:
3038:
3035:
3030:
3026:
3022:
3018:
3014:
3010:
3007:(8): 644–53.
3006:
3002:
2995:
2992:
2987:
2983:
2978:
2973:
2969:
2965:
2962:(8): 617–27.
2961:
2957:
2953:
2946:
2943:
2938:
2934:
2929:
2924:
2920:
2916:
2912:
2908:
2907:Small GTPases
2904:
2897:
2894:
2889:
2885:
2880:
2875:
2871:
2867:
2863:
2859:
2855:
2848:
2845:
2840:
2836:
2832:
2828:
2823:
2818:
2814:
2810:
2806:
2799:
2796:
2791:
2787:
2782:
2777:
2773:
2769:
2765:
2761:
2757:
2750:
2747:
2742:
2738:
2733:
2728:
2725:(4): 483–95.
2724:
2720:
2716:
2709:
2706:
2701:
2697:
2693:
2689:
2685:
2681:
2677:
2673:
2669:
2665:
2658:
2655:
2650:
2646:
2642:
2636:
2631:
2626:
2622:
2615:
2612:
2607:
2603:
2598:
2593:
2589:
2585:
2581:
2574:
2571:
2566:
2562:
2558:
2554:
2550:
2546:
2539:
2537:
2533:
2528:
2524:
2520:
2516:
2512:
2508:
2504:
2500:
2493:
2490:
2485:
2481:
2477:
2473:
2469:
2465:
2457:
2455:
2451:
2446:
2442:
2436:
2433:
2428:
2424:
2418:
2415:
2411:
2407:
2402:
2400:
2398:
2394:
2390:
2386:
2381:
2379:
2377:
2373:
2367:
2365:
2358:
2356:
2349:
2347:
2344:
2338:
2334:
2327:
2322:
2316:
2313:
2310:
2307:
2304:
2301:
2298:
2295:
2292:
2289:
2286:
2283:
2280:
2277:
2274:
2271:
2268:
2265:
2262:
2259:
2256:
2253:
2250:
2247:
2244:
2241:
2238:
2235:
2232:
2229:
2226:
2223:
2221:
2218:
2215:
2212:
2209:
2206:
2203:
2200:
2197:
2194:
2191:
2188:
2185:
2182:
2181:
2179:
2177:
2169:
2167:
2165:
2161:
2157:
2153:
2149:
2144:
2142:
2138:
2134:
2130:
2122:
2120:
2117:
2108:
2106:
2099:
2097:
2095:
2086:
2084:
2081:
2077:
2068:
2066:
2060:
2058:
2055:
2051:
2047:
2039:
2037:
2033:
2031:
2025:
2023:
2019:
2013:
2011:
2003:
2001:
1999:
1998:cell division
1995:
1991:
1990:
1985:
1981:
1977:
1973:
1970:
1966:
1962:
1959:
1955:
1951:
1947:
1935:
1930:
1926:
1922:
1919:
1915:
1908:
1906:
1903:
1899:
1895:
1891:
1888:
1884:
1880:
1873:
1871:
1867:
1863:
1857:
1853:
1850:
1844:
1842:
1838:
1834:
1830:
1824:
1820:
1816:
1812:
1808:
1804:
1800:
1797:
1793:
1786:
1784:
1780:
1776:
1770:
1766:
1763:
1757:
1755:
1751:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1718:
1716:RefSeq (mRNA)
1714:
1707:
1706:
1701:
1697:
1694:
1688:
1687:
1682:
1678:
1675:
1673:
1669:
1662:
1661:
1656:
1652:
1649:
1643:
1642:
1637:
1633:
1630:
1628:
1624:
1617:
1616:
1611:
1607:
1604:
1598:
1597:
1592:
1588:
1585:
1583:
1579:
1576:
1573:
1571:
1568:
1564:
1561:
1557:
1553:
1546:
1542:
1537:
1531:
1528:
1526:
1523:
1521:
1518:
1516:
1513:
1511:
1508:
1506:
1503:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1483:
1481:
1478:
1476:
1473:
1471:
1468:
1466:
1463:
1461:
1458:
1456:
1453:
1451:
1448:
1446:
1443:
1441:
1438:
1436:
1433:
1431:
1428:
1426:
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1396:
1393:
1391:
1388:
1386:
1383:
1381:
1378:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1351:
1348:
1346:
1345:odontogenesis
1343:
1341:
1338:
1336:
1333:
1331:
1328:
1326:
1323:
1321:
1318:
1316:
1313:
1311:
1308:
1306:
1303:
1301:
1298:
1296:
1293:
1291:
1288:
1286:
1283:
1281:
1278:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1235:cell adhesion
1233:
1231:
1228:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1120:viral process
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1045:cell division
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
967:
965:
962:
961:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
899:lamellipodium
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
859:cell junction
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
806:
804:
801:
800:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
750:
748:
745:
744:
741:
740:Gene ontology
737:
733:
721:
716:
712:
705:
698:
693:
690:
688:
684:
676:
671:
660:
656:
652:
648:
644:
640:
636:
632:
628:
624:
623:
620:
616:
611:
608:
598:
594:
590:
586:
582:
578:
574:
570:
566:
562:
561:
558:
554:
549:
546:
545:
542:
540:
536:
534:
533:
529:
528:
525:
523:
519:
515:
511:
507:
499:
494:
490:
486:
481:
471:
467:
460:
453:
447:
440:
432:
428:
424:
419:
415:
410:
406:
398:
393:
389:
385:
380:
370:
366:
359:
352:
346:
339:
335:
329:
325:
321:
316:
312:
307:
303:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
255:
250:
243:
238:
233:
222:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
32:
31:
19:
6894:Translocases
6891:
6878:
6865:
6852:
6839:
6829:Transferases
6826:
6813:
6670:Binding site
6407:
6341:
6297:
6275:
6260:Small GTPase
5874:Wilson/ATP7B
5869:Menkes/ATP7A
5714:
5699:
5684:
5669:
5654:
5639:
5624:
5609:
5594:
5579:
5564:
5549:
5534:
5519:
5504:
5489:
5429:
5408:
5374:rhoA+Protein
5340:
5336:
5302:(4): 191–9.
5299:
5295:
5268:
5264:
5258:
5233:
5229:
5223:
5188:
5184:
5174:
5137:
5133:
5123:
5096:
5092:
5082:
5055:
5051:
5041:
5006:
5002:
4992:
4965:
4961:
4951:
4924:
4920:
4910:
4875:
4871:
4861:
4826:
4822:
4812:
4777:
4773:
4763:
4736:
4732:
4722:
4695:
4691:
4681:
4646:
4642:
4632:
4607:
4603:
4597:
4562:
4558:
4548:
4513:
4509:
4499:
4472:
4468:
4428:
4424:
4414:
4379:
4375:
4365:
4335:(2): 200–8.
4332:
4328:
4318:
4291:
4287:
4277:
4242:
4238:
4228:
4206:(1): 69–74.
4203:
4199:
4193:
4171:(2): 541–7.
4168:
4164:
4158:
4123:
4119:
4109:
4082:
4078:
4035:(5): 540–6.
4032:
4028:
4022:
3995:
3991:
3981:
3949:(2): 243–8.
3946:
3943:FEBS Letters
3942:
3932:
3897:
3893:
3849:
3845:
3835:
3793:(2): 733–8.
3790:
3786:
3776:
3746:(3): 313–8.
3743:
3740:FEBS Letters
3739:
3733:
3708:
3704:
3698:
3665:
3662:FEBS Letters
3661:
3655:
3620:
3616:
3606:
3579:
3575:
3565:
3530:
3526:
3516:
3481:
3477:
3467:
3440:
3436:
3426:
3399:
3395:
3385:
3360:
3357:Biochemistry
3356:
3350:
3309:
3305:
3299:
3269:(5): 461–7.
3266:
3262:
3256:
3229:
3225:
3215:
3180:
3176:
3166:
3141:
3137:
3131:
3090:
3086:
3080:
3047:
3043:
3037:
3004:
3000:
2994:
2959:
2955:
2945:
2913:(3): 141–7.
2910:
2906:
2896:
2861:
2857:
2847:
2812:
2808:
2798:
2766:(1): 27–36.
2763:
2759:
2749:
2722:
2718:
2708:
2667:
2663:
2657:
2620:
2614:
2587:
2583:
2573:
2548:
2544:
2502:
2498:
2492:
2467:
2463:
2444:
2435:
2426:
2417:
2362:
2353:
2339:
2335:
2331:
2173:
2170:Interactions
2164:Neurotrophin
2152:neurotrophin
2145:
2126:
2123:RhoA pathway
2112:
2103:
2090:
2072:
2064:
2043:
2034:
2026:
2014:
2009:
2007:
1987:
1968:
1958:small GTPase
1953:
1949:
1945:
1944:
1866:NP_001300891
1862:NP_001300890
1859:
1829:NP_001300876
1826:
1819:NP_001300875
1815:NP_001300874
1811:NP_001300873
1807:NP_001300872
1803:NP_001300870
1783:NM_001313962
1779:NM_001313961
1772:
1750:NM_001313947
1747:
1740:NM_001313946
1736:NM_001313945
1732:NM_001313944
1728:NM_001313943
1724:NM_001313941
1703:
1684:
1658:
1639:
1613:
1594:
1574:
1569:
879:cytoskeleton
633:aortic valve
537:
530:
496:108,215,133
483:108,183,328
257:External IDs
92:
29:
6665:Active site
6584:Mitofusin-1
6559:3.6.5.5-6:
6528:Prokaryotic
5472:PDB gallery
2551:(1): 43–9.
2148:growth cone
2141:Reticulon 4
2030:prenylation
1841:NP_001655.1
944:postsynapse
864:cell cortex
778:GDP binding
763:GTP binding
637:granulocyte
591:skin of arm
567:skin of hip
475:9|9 F2
395:49,412,998
382:49,359,139
235:Identifiers
6937:Categories
6868:Isomerases
6842:Hydrolases
6709:Regulation
6550:Eukaryotic
6183:Transducin
6020:(3.6.3.10)
5759:Hydrolases
2412:, May 2017
2391:, May 2017
2368:References
1989:Drosophila
1115:cell cycle
653:belly cord
587:right lung
541:(ortholog)
278:HomoloGene
6747:EC number
6518:3.6.5.3:
6258:3.6.5.2:
6200:Gustducin
6132:3.6.5.1:
5966:(3.6.3.9)
5886:(3.6.3.8)
5789:Inorganic
5140:(1): 16.
3705:Biochimie
3533:(1): 89.
2116:cyclin D1
2004:Structure
1870:NP_058082
1833:NP_001655
1775:NM_016802
1754:NM_001664
1560:Orthologs
809:cytoplasm
286:GeneCards
6948:EC 3.6.5
6771:Kinetics
6695:Cofactor
6658:Activity
5794:Thiamine
5391:Archived
5359:16496227
5324:13941716
5316:11998687
5277:21034566
5250:18991642
5215:22726684
5166:22443473
5115:18922976
5074:19372585
5033:22456196
4984:10948190
4853:12446789
4804:12857875
4755:11948427
4733:Oncogene
4673:11311142
4624:12593858
4589:12071848
4406:21129722
4357:33717402
4349:12115726
4310:14581471
4269:11689693
4185:11162552
4150:13943167
4101:12766172
4057:19812449
4049:15069594
4014:10066731
3973:39746553
3924:12773565
3868:12221096
3827:12515866
3760:10526156
3725:11368848
3690:10817327
3647:11149925
3598:15659383
3557:17353931
3508:12842009
3334:16189514
3291:10865814
3283:12692556
3248:10595511
3207:26661165
3158:12951059
3064:15184901
3029:11890502
3021:16858392
2986:16858390
2937:24025634
2888:19470758
2839:16243409
2790:11160820
2741:15068789
2649:32808262
2565:15501444
2527:11149758
2519:15932062
2408:–
2387:–
2291:RAP1GDS1
2208:ARHGEF12
2202:ARHGEF11
2176:interact
1956:), is a
1918:Wikidata
1539:Sources:
839:membrane
824:endosome
563:monocyte
6927:Biology
6881:Ligases
6651:Enzymes
6605:Tubulin
6574:Dynamin
6426:other:
6106:Katanin
6096:Kinesin
6071:ATP13A3
6066:ATP13A2
5801:Apyrase
5436:PDBe-KB
5426:UniProt
5415:PDBe-KB
5405:UniProt
5206:3383629
5157:3353160
5024:3355556
4943:8798490
4902:8816443
4714:9535835
4664:1221795
4580:1222665
4540:9199174
4531:2137826
4491:9446575
4447:8910519
4397:2997363
4220:8769096
4142:9635436
3965:8543060
3795:Bibcode
3768:8529412
3682:9490022
3638:2193662
3548:1847948
3499:6918695
3459:9535855
3418:9407060
3377:9548756
3342:4427026
3314:Bibcode
3198:4908617
3123:4352534
3115:7477407
3095:Bibcode
3072:9613584
2977:2693386
2928:3976970
2879:2715793
2831:7600583
2700:4344860
2692:9153394
2672:Bibcode
2606:9545299
2484:9605859
2410:Ensembl
2389:Ensembl
2214:ARHGEF3
2196:ARHGDIA
2190:ARHGAP5
2184:ARHGAP1
2137:cofilin
1963:in the
1961:protein
1672:UniProt
1627:Ensembl
1566:Species
1545:QuickGO
914:nucleus
869:midbody
819:cytosol
814:vesicle
657:decidua
516:pattern
374:3p21.31
274:1096342
242:Aliases
6913:Portal
6855:Lyases
6482:ARL13B
6342:RhoBTB
6236:α12/13
6124:GTPase
6101:Myosin
6091:Dynein
6061:ATP12A
6056:ATP11B
6051:ATP10A
6046:ATP8B1
6036:Other
6008:ATP1B4
6003:ATP1B3
5998:ATP1B2
5993:ATP1B1
5988:ATP1A4
5983:ATP1A3
5978:ATP1A2
5973:ATP1A1
5964:Na+/K+
5952:ATP2C2
5947:ATP2C1
5935:ATP2B4
5930:ATP2B3
5925:ATP2B2
5920:ATP2B1
5908:ATP2A3
5903:ATP2A2
5898:ATP2A1
5847:ATPase
5431:Q9QUI0
5410:P61586
5380:(MeSH)
5357:
5322:
5314:
5275:
5248:
5213:
5203:
5164:
5154:
5113:
5072:
5031:
5021:
4982:
4941:
4900:
4893:231530
4890:
4851:
4844:139861
4841:
4802:
4795:165687
4792:
4753:
4712:
4671:
4661:
4622:
4587:
4577:
4538:
4528:
4489:
4445:
4404:
4394:
4355:
4347:
4308:
4267:
4257:
4218:
4183:
4148:
4140:
4099:
4055:
4047:
4012:
3971:
3963:
3922:
3915:156133
3912:
3866:
3825:
3818:141065
3815:
3766:
3758:
3723:
3688:
3680:
3645:
3635:
3596:
3555:
3545:
3506:
3496:
3457:
3416:
3375:
3340:
3332:
3306:Nature
3289:
3281:
3246:
3226:Neuron
3205:
3195:
3156:
3121:
3113:
3087:Nature
3070:
3062:
3027:
3019:
2984:
2974:
2935:
2925:
2886:
2876:
2837:
2829:
2788:
2778:
2739:
2698:
2690:
2664:Nature
2647:
2637:
2604:
2563:
2525:
2517:
2482:
2328:Cancer
2311:, and
2261:MAP3K1
2231:DIAPH1
2178:with:
2129:LINGO1
2076:uropod
1984:DIAPH1
1904:search
1902:PubMed
1705:Q9QUI0
1686:P61586
1582:Entrez
687:BioGPS
649:dermis
645:thymus
583:thymus
266:165390
6807:Types
6538:EF-Tu
6477:SAR1B
6460:RAB27
6455:RAB23
6408:RhoDF
6298:RhoUV
6281:CDC42
6276:Cdc42
6262:>
6247:GNA13
6242:GNA12
6227:GNA11
6216:αq/11
6205:GNAT3
6193:GNAT2
6188:GNAT1
6178:GNAI3
6173:GNAI2
6168:GNAI1
6120:3.6.5
6084:3.6.4
6027:ATP4A
6018:H+/K+
5893:SERCA
5855:3.6.3
5839:3.6.3
5816:3.6.2
5776:3.6.1
5320:S2CID
4353:S2CID
4260:99969
4146:S2CID
4053:S2CID
3969:S2CID
3764:S2CID
3686:S2CID
3338:S2CID
3287:S2CID
3119:S2CID
3068:S2CID
3025:S2CID
2835:S2CID
2781:30565
2696:S2CID
2523:S2CID
2315:TRPC1
2303:ROCK1
2273:PLCG1
2249:KCNA2
2243:ITPR1
1980:ROCK1
1976:actin
1615:11848
1575:Mouse
1570:Human
1541:Amigo
539:Mouse
532:Human
479:Start
414:Mouse
378:Start
311:Human
282:68986
6899:list
6892:EC7
6886:list
6879:EC6
6873:list
6866:EC5
6860:list
6853:EC4
6847:list
6840:EC3
6834:list
6827:EC2
6821:list
6814:EC1
6598:OPA1
6591:and
6543:EF-G
6533:IF-2
6499:Rheb
6487:ARL6
6472:ARF6
6443:NRAS
6438:KRAS
6433:HRAS
6418:RhoD
6413:RhoF
6359:RhoH
6335:RhoG
6320:Rac1
6308:RhoV
6303:RhoU
6286:TC10
6222:GNAQ
5942:SPCA
5769:3.6)
5715:2gcp
5700:2gco
5685:2gcn
5670:1z2c
5655:1xcg
5640:1x86
5625:1tx4
5610:1s1c
5595:1ow3
5580:1lb1
5565:1kmq
5550:1ftn
5535:1dpf
5520:1cxz
5505:1cc0
5490:1a2b
5424:for
5403:for
5384:RHOA
5355:PMID
5312:PMID
5273:PMID
5246:PMID
5211:PMID
5162:PMID
5111:PMID
5070:PMID
5029:PMID
4980:PMID
4939:PMID
4898:PMID
4849:PMID
4800:PMID
4751:PMID
4710:PMID
4669:PMID
4620:PMID
4585:PMID
4536:PMID
4487:PMID
4443:PMID
4402:PMID
4345:PMID
4306:PMID
4265:PMID
4216:PMID
4181:PMID
4138:PMID
4120:Cell
4097:PMID
4045:PMID
4010:PMID
3961:PMID
3920:PMID
3864:PMID
3823:PMID
3756:PMID
3721:PMID
3678:PMID
3643:PMID
3594:PMID
3553:PMID
3504:PMID
3455:PMID
3414:PMID
3373:PMID
3330:PMID
3279:PMID
3244:PMID
3203:PMID
3154:PMID
3111:PMID
3060:PMID
3017:PMID
2982:PMID
2933:PMID
2884:PMID
2827:PMID
2809:Cell
2786:PMID
2737:PMID
2688:PMID
2645:PMID
2635:ISBN
2602:PMID
2561:PMID
2515:PMID
2480:PMID
2309:TRIO
2297:RICS
2267:PKN2
2255:KTN1
2237:GEFT
2225:DGKQ
2160:Nogo
2080:ROCK
2010:RHOA
1972:gene
1969:RHOA
1954:RhoA
919:axon
522:Bgee
470:Band
431:Chr.
369:Band
328:Chr.
290:RHOA
262:OMIM
249:RHOA
219:5HPY
215:5C4M
211:5C2K
207:5JCP
203:5FR1
199:5FR2
195:5A0F
191:4XOI
187:4XSH
183:4XSG
179:4XH9
175:4D0N
171:3T06
167:3MSX
163:3LXR
159:3LWN
155:3LW8
151:3KZ1
147:2RGN
143:1XCG
139:1X86
135:1TX4
131:1S1C
127:1OW3
123:1LB1
119:1KMQ
115:1FTN
111:1DPF
107:1CXZ
103:1CC0
99:1A2B
95:5BWM
76:RCSB
73:PDBe
42:RHOA
18:RHOA
6593:MX2
6589:MX1
6509:RGK
6504:Rap
6494:Ran
6467:Arf
6450:Rab
6428:Ras
6386:Rnd
6364:Rho
6315:Rac
6291:TCL
6152:olf
5884:Ca+
5422:PDB
5401:PDB
5345:doi
5304:doi
5269:123
5238:doi
5201:PMC
5193:doi
5152:PMC
5142:doi
5101:doi
5060:doi
5019:PMC
5011:doi
4970:doi
4966:275
4929:doi
4925:271
4888:PMC
4880:doi
4839:PMC
4831:doi
4790:PMC
4782:doi
4741:doi
4700:doi
4696:273
4659:PMC
4651:doi
4647:355
4612:doi
4608:302
4575:PMC
4567:doi
4563:365
4526:PMC
4518:doi
4514:137
4477:doi
4473:273
4433:doi
4429:271
4392:PMC
4384:doi
4337:doi
4333:192
4296:doi
4292:279
4255:PMC
4247:doi
4208:doi
4204:225
4173:doi
4169:280
4128:doi
4087:doi
4083:278
4037:doi
4033:369
4000:doi
3996:274
3951:doi
3947:377
3910:PMC
3902:doi
3854:doi
3850:277
3813:PMC
3803:doi
3791:100
3748:doi
3744:459
3713:doi
3670:doi
3666:422
3633:PMC
3625:doi
3621:152
3584:doi
3580:280
3543:PMC
3535:doi
3494:PMC
3486:doi
3445:doi
3441:273
3404:doi
3400:272
3365:doi
3322:doi
3310:437
3271:doi
3234:doi
3193:PMC
3185:doi
3146:doi
3142:309
3103:doi
3091:378
3052:doi
3009:doi
2972:PMC
2964:doi
2923:PMC
2915:doi
2874:PMC
2866:doi
2817:doi
2776:PMC
2768:doi
2727:doi
2680:doi
2668:387
2625:doi
2592:doi
2588:273
2553:doi
2549:301
2507:doi
2472:doi
2220:CIT
2133:p75
2050:GTP
2048:to
2046:GDP
2022:GTP
2020:or
2018:GDP
1596:387
492:End
391:End
294:OMA
270:MGI
66:PDB
6939::
6274::
6162:αi
6144:αs
6122::
5845::
5767:EC
5761::
5428::
5407::
5353:.
5341:13
5339:.
5335:.
5318:.
5310:.
5300:25
5298:.
5267:.
5244:.
5234:15
5232:.
5209:.
5199:.
5189:19
5187:.
5183:.
5160:.
5150:.
5138:11
5136:.
5132:.
5109:.
5095:.
5091:.
5068:.
5054:.
5050:.
5027:.
5017:.
5007:26
5005:.
5001:.
4978:.
4964:.
4960:.
4937:.
4923:.
4919:.
4896:.
4886:.
4876:16
4874:.
4870:.
4847:.
4837:.
4827:22
4825:.
4821:.
4798:.
4788:.
4778:14
4776:.
4772:.
4749:.
4737:21
4735:.
4731:.
4708:.
4694:.
4690:.
4667:.
4657:.
4645:.
4641:.
4618:.
4606:.
4583:.
4573:.
4561:.
4557:.
4534:.
4524:.
4512:.
4508:.
4485:.
4471:.
4467:.
4455:^
4441:.
4427:.
4423:.
4400:.
4390:.
4380:87
4378:.
4374:.
4351:.
4343:.
4331:.
4327:.
4304:.
4290:.
4286:.
4263:.
4253:.
4243:21
4241:.
4237:.
4214:.
4202:.
4179:.
4167:.
4144:.
4136:.
4124:93
4122:.
4118:.
4095:.
4081:.
4077:.
4065:^
4051:.
4043:.
4031:.
4008:.
3994:.
3990:.
3967:.
3959:.
3945:.
3941:.
3918:.
3908:.
3898:23
3896:.
3892:.
3876:^
3862:.
3848:.
3844:.
3821:.
3811:.
3801:.
3789:.
3785:.
3762:.
3754:.
3742:.
3719:.
3709:83
3707:.
3684:.
3676:.
3664:.
3641:.
3631:.
3619:.
3615:.
3592:.
3578:.
3574:.
3551:.
3541:.
3529:.
3525:.
3502:.
3492:.
3482:13
3480:.
3476:.
3453:.
3439:.
3435:.
3412:.
3398:.
3394:.
3371:.
3361:37
3359:.
3336:.
3328:.
3320:.
3308:.
3285:.
3277:.
3265:.
3242:.
3230:24
3228:.
3224:.
3201:.
3191:.
3181:36
3179:.
3175:.
3152:.
3140:.
3117:.
3109:.
3101:.
3089:.
3066:.
3058:.
3046:.
3023:.
3015:.
3003:.
2980:.
2970:.
2958:.
2954:.
2931:.
2921:.
2909:.
2905:.
2882:.
2872:.
2862:29
2860:.
2856:.
2833:.
2825:.
2813:81
2811:.
2807:.
2784:.
2774:.
2764:12
2762:.
2758:.
2735:.
2721:.
2717:.
2694:.
2686:.
2678:.
2666:.
2643:.
2633:.
2600:.
2586:.
2582:.
2559:.
2547:.
2535:^
2521:.
2513:.
2503:43
2501:.
2478:.
2468:79
2466:.
2453:^
2443:.
2425:.
2396:^
2375:^
2131:,
1543:/
498:bp
485:bp
397:bp
384:bp
292:;
288::
284:;
280::
276:;
272::
268:;
264::
217:,
213:,
209:,
205:,
201:,
197:,
193:,
189:,
185:,
181:,
177:,
173:,
169:,
165:,
161:,
157:,
153:,
149:,
145:,
141:,
137:,
133:,
129:,
125:,
121:,
117:,
113:,
109:,
105:,
101:,
97:,
6915::
6901:)
6897:(
6888:)
6884:(
6875:)
6871:(
6862:)
6858:(
6849:)
6845:(
6836:)
6832:(
6823:)
6819:(
6643:e
6636:t
6629:v
6401:3
6396:2
6391:1
6379:C
6374:B
6369:A
6352:2
6347:1
6330:3
6325:2
6234:G
6214:G
6160:G
6150:G
6142:G
5843:4
5841:-
5765:(
5751:e
5744:t
5737:v
5465:e
5458:t
5451:v
5438:.
5417:.
5361:.
5347::
5326:.
5306::
5279:.
5252:.
5240::
5217:.
5195::
5168:.
5144::
5117:.
5103::
5097:6
5076:.
5062::
5056:7
5035:.
5013::
4986:.
4972::
4945:.
4931::
4904:.
4882::
4855:.
4833::
4806:.
4784::
4757:.
4743::
4716:.
4702::
4675:.
4653::
4626:.
4614::
4591:.
4569::
4542:.
4520::
4493:.
4479::
4449:.
4435::
4408:.
4386::
4359:.
4339::
4312:.
4298::
4271:.
4249::
4222:.
4210::
4187:.
4175::
4152:.
4130::
4103:.
4089::
4059:.
4039::
4016:.
4002::
3975:.
3953::
3926:.
3904::
3870:.
3856::
3829:.
3805::
3797::
3770:.
3750::
3727:.
3715::
3692:.
3672::
3649:.
3627::
3600:.
3586::
3559:.
3537::
3531:3
3510:.
3488::
3461:.
3447::
3420:.
3406::
3379:.
3367::
3344:.
3324::
3316::
3293:.
3273::
3267:6
3250:.
3236::
3209:.
3187::
3160:.
3148::
3125:.
3105::
3097::
3074:.
3054::
3048:7
3031:.
3011::
3005:7
2988:.
2966::
2960:7
2939:.
2917::
2911:4
2890:.
2868::
2841:.
2819::
2792:.
2770::
2743:.
2729::
2723:6
2702:.
2682::
2674::
2651:.
2627::
2608:.
2594::
2567:.
2555::
2529:.
2509::
2486:.
2474::
2447:.
2429:.
2317:.
2305:,
2299:,
2293:,
2287:,
2281:,
2275:,
2269:,
2263:,
2257:,
2251:,
2245:,
2239:,
2233:,
2227:,
2216:,
2210:,
2204:,
2198:,
2192:,
2186:,
2074:(
1952:(
416:)
313:)
296::
33:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
