691:
virus disease (EVD) received either "immediate" or 21-day "delayed" vaccination with Ervebo. This noteworthy design was intended to capture a social network of individuals and locations that might include dwellings or workplaces where a patient spent time while symptomatic, or the households of individuals who had contact with the patient during that person's illness or death. In a comparison of cases of EVD among 2,108 individuals in the "immediate" vaccination arm and 1,429 individuals in the "delayed" vaccination arm, Ervebo was determined to be 100% effective in preventing Ebola cases with symptom onset greater than ten days after vaccination. No cases of EVD with symptom onset greater than ten days after vaccination were observed in the "immediate" cluster group, compared with ten cases of EVD in the 21-day "delayed" cluster group.
635:(NAM) published a review of the response to the Ebola outbreak that included a discussion of how clinical trial candidates were selected, how trials were designed and conducted, and reviewed the data resulting from the trials. The committee found that data from the Phase III Guinea trial were difficult to interpret for several reasons. The trial had no placebo arm; it was omitted for ethical reasons and everyone involved, including the committee, agreed with the decision. This left only a delayed treatment group to serve as a control, but this group was eliminated after an interim analysis showed high levels of protection, which left the trial even more
544:
2845:
is critically important. The recent example of Merck abandoning the development of rVSV vaccines for
Marburg (rVSV-MARV) and for Sudan-Ebola (rVSV-SUDV) is a case in point. Merck continues to retain vital know-how on the rVSV platform as it developed the rVSV vaccine for Zaire-Ebola (rVSV-ZEBOV) with funding support from GAVI. While it has transferred the rights on these vaccines back to Public Health Agency of Canada, there is no mechanism to share know how on the rVSV platform with other vaccine developers who would like to also use rVSV as a vector against other pathogens.
749:
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42:
4226:
5803:
5791:
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1378:
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559:(PHAC) created the vaccine, and PHAC applied for a patent in 2003. From 2005, to 2009, three animal trials on the virus were published, all of them funded by the Canadian and U.S. governments. In 2005, a single intramuscular injection of the EBOV or MARV vaccine was found to induce completely protective immune responses in nonhuman primates (
579:
vaccine in production and no human trials underway, and there were calls for the
Canadian government to cancel the contract. In September or October 2014, Newlink formed a steering committee among the interested parties, including PHAC, the NIH, and the WHO, to plan the clinical development of the vaccine.
2844:
In vaccine development, access to know how is important. Knowledge and expertise including but not limited to purification techniques, cell lines, materials, software codes and their transfer of this to alternative manufacturers in the event the awardee discontinues development of a promising vaccine
578:
started in West Africa, specifically, in Guinea. On August 12, the WHO ruled that offering people infected with Ebola the RVSV-ZEBOV vaccine (which at the time was untested on humans) was ethical, and the
Canadian government donated 500 doses of the vaccine to the WHO. In October 2014, Newlink had no
582:
In
October 2014, Newlink Genetics began a Phase I clinical trial of rVSV-ZEBOV on healthy human subjects to evaluate the immune response, identify any side effects and determine the appropriate dosage. Phase I trials took place in Gabon, Kenya, Germany, Switzerland, the US, and Canada. In November
694:
In additional studies, antibody responses to Ervebo were assessed in 477 individuals in
Liberia, approximately 500 individuals in Sierra Leone and approximately 900 individuals in Canada, Spain, and the US. The antibody responses among those in the study conducted in Canada, Spain and the US were
690:
The approval of Ervebo was supported by a study conducted in Guinea during the 2014-2016 outbreak in individuals 18 years of age and older. The study was a randomized cluster (ring) vaccination study in which 3,537 contacts, and contacts of contacts, of individuals with laboratory-confirmed Ebola
2529:
Keusch G, McAdam K, Cuff P, Mancher M, Busta ER, et al. (Health
Committee on Clinical Trials During the 2014-2015 Ebola Outbreak, Board on Health Sciences Policy, Division of Health And Medicine, National Academies of Sciences, Engineering, and Medicine) (2017). Keusch G, McAdam K, Cuff P,
698:
The safety of Ervebo was assessed in approximately 15,000 individuals in Africa, Europe and North
America. The most commonly reported side effects were pain, swelling and redness at the injection site, as well as headache, fever, joint and muscle aches and fatigue.
566:
In 2010, PHAC licensed the intellectual property on the vaccine to a small U.S. company called
Bioprotection Systems, which was a subsidiary of Newlink Genetics, for US $ 205,000 and "low single-digit percentage" royalties. Newlink had funding from the U.S.
627:
Results of the Phase III Guinea trial were published in
December 2016. It was widely reported in the media that vaccine was safe and appeared to be nearly 100% effective, but the vaccine remained unavailable for commercial use as of December 2016.
765:
436:
768:, the ZEBOV vaccine was used, and what was once contact tracing which numbered 1,706 individuals (ring vaccination which totaled 3,330) was reduced to zero on June 28, 2018. The outbreak completed the required 42-day cycle on July 24.
1363:
643:, the rVSV-ZEBOV vaccine might have had no efficacy, agreed with the authors of the December 2016 report that it probably had some efficacy, but found statements that it had substantial or 100% efficacy to be unsupportable.
3428:
2196:
646:
In April 2019, following a large-scale ring-vaccination scheme in the DRC outbreak, preliminary results showed that the vaccine had been 97.5% effective at stopping Ebola transmission, relative to no vaccination.
479:
Systemic side effects include headache, feverishness, fatigue, joint and muscle pain, nausea, arthritis, rash, and abnormal sweating. Injection-site side events include injection-site pain, swelling, and redness.
3175:
1595:
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1195:
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740:
In July 2023, the FDA expanded the approval of Ervebo for use in people aged 12 months through 17 years of age. Ervebo was approved for use in people aged 18 years of age and older in
December 2019.
3206:
802:"rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment"
624:(WHO) through their Emergency Use Assessment and Listing (EUAL) program to allow for use of the vaccine in the case of another epidemic. It was used on an emergency basis in Guinea in March 2016.
2029:
1441:
3105:
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World Health Organization, Regional Office for Africa, Health Emergencies Programme (June 2017). Ebola Virus Disease Democratic Republic of the Congo: External Situation Report 22 (Report).
452:
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In March 2015, a Phase II clinical trial and a Phase III started in Guinea at the same time; the Phase II trial focused on frontline health workers, while the Phase III trial was a
2621:
1931:
1153:
381:, rVSV-ZEBOV has shown a high level of protection. Around half the people given the vaccine have mild to moderate adverse effects that include headache, fatigue, and muscle pain.
2274:
894:
185:
1914:
3083:
2240:
2676:
463:
In April 2019, following a large-scale ring-vaccination scheme in the DRC outbreak, the WHO published the preliminary results of its research, in association with the DRC's
2356:
2271:"A Phase 1 Randomized, Double-Blind, Placebo Controlled, Dose-Escalation Study to Evaluate the Safety and Immunogenicity of Prime-Boost VSV Ebola Vaccine in Healthy Adults"
2193:
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933:
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1893:
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was declared in North Kivu DRC. After six months the current totals stand at 735 total cases and 371 deaths; violence in the region has helped the spread of the virus.
1584:
2764:
680:(WHO) prequalified an Ebola vaccine for the first time, indicating that the vaccine met WHO standards for quality, safety and efficacy, and allowing UN agencies and
3973:
1664:
464:
3053:
2790:
451:
Nearly 800 people were ring vaccinated on an emergency basis with VSV-EBOV when another Ebola outbreak occurred in Guinea in March 2016. In 2017, in the face of a
4842:
2144:
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3958:
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106:
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2937:
519:
1995 Zaire strain. Manufacturing of the vaccine for the Phase I trial was done by IDT Biologika. Manufacturing of vaccine for the Phase III trial was done by
4882:
4877:
3963:
3232:
1184:
3014:
143:
3948:
3198:
2319:
2644:"FDA Accepts Merck's Biologics License Application (BLA) and Grants Priority Review for V920, the Company's Investigational Vaccine for Ebola Zaire Virus"
5843:
3423:
2831:
2643:
2021:
856:
733:). Merck returned the rights on these vaccines back to Public Health Agency of Canada. The knowledge on developing rVSV vaccines which Merck gained with
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2429:
1431:
4644:
2084:
3483:
3513:
5274:
2742:
2709:
2504:
2270:
2106:
1912:
The strange tale of Canada's ebola vaccine: Walkom. Commercial rights to a vaccine worth $ 50 million were sold to a U.S. middleman for $ 205,000.
1551:
620:; Merck will use the funds to complete clinical trials and obtain regulatory approval. As of that date, Merck had submitted an application to the
1625:
2213:
4892:
3912:
3478:
1356:"First FDA-approved vaccine for the prevention of Ebola virus disease, marking a critical milestone in public health preparedness and response"
5745:
5673:
4629:
4615:
4595:
4272:
3370:
2547:
1528:
5279:
3816:
3468:
3418:
2054:
1943:
862:
5311:
4994:
4847:
3135:"Ebola RDC – Evolution de la riposte contre l'épidémie d'Ebola dans les provinces du Nord Kivu et de l'Ituri au Vendredi 4 janvier 2019"
2613:
1145:
575:
2897:"Ebola RDC – Evolution de la riposte contre l'épidémie d'Ebola dans les provinces du Nord Kivu et de l'Ituri au Lundi 31 décembre 2018"
1911:
884:
5721:
5063:
5033:
4666:
4295:
3953:
3438:
973:
616:
signed an agreement with Merck under which Merck agreed to provide VSV-EBOV vaccine for future outbreaks of Ebola and GAVI paid Merck
551:
started and affected nearby countries, in the end causing more than 28,000 cases with about 45% of the total number ending in fatality
5133:
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3075:
2248:
2665:
2352:
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The vaccine was approved for medical use in the European Union and the United States in 2019. It was created by scientists at the
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1403:
412:
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3142:
925:
5321:
5289:
5118:
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3413:
2904:
568:
215:
124:
5379:
543:
5838:
5828:
4989:
3448:
1890:
636:
556:
420:
4239:
5177:
4887:
2960:"Ebola RDC – Communication spéciale du Ministre de la Santé concernant l'évolution de la neuvième épidémie d'Ebola en RDC"
655:
5781:
1648:
670:
602:
of the joints of the affected people; the clinical trial was halted because of that, then recommenced with a lower dose.
3473:
3045:
3015:"WHO AFRO Outbreaks and Other Emergencies, Week 26: 23 - 29 June 2018 (Data as reported by 17:00; 29 June 2018) - World"
2864:
2765:"Merck's Ervebo [Ebola Zaire Vaccine (rVSVΔG-ZEBOV-GP) live] Granted Conditional Approval in the European Union"
2473:
1399:
1359:
711:
651:
632:
329:
4229:
2136:
5762:
4578:
3747:
3458:
3443:
640:
783:
Preliminary results show ring vaccination with the vaccine has been highly effective at reducing Ebola transmission.
2300:
1962:
Published PCT Application WO2004011488: Recombinant vesicular stomatitis virus vaccines for viral hemorrhagic fevers
5299:
4741:
4724:
3737:
2959:
2927:
492:
393:
3260:"EBOLA VACCINE. VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain"
3242:
2081:"Sole Redacted License Agreement for Recombinant Vesicular Stomatitis Virus Vaccines for Viral Hemorrhagic Fevers"
160:
5349:
4265:
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3169:
3110:
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2703:
2670:
2434:
2330:
2324:
2110:
1687:
1589:
1189:
967:
677:
666:
621:
138:
1271:"Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020"
5304:
5269:
5264:
5259:
3342:
3106:"Ebola outbreak in DRC ends: WHO calls for international efforts to stop other deadly outbreaks in the country"
2860:
777:
752:
3587:
3327:
2823:
2440:
5750:
5683:
5664:
5460:
5432:
5394:
5389:
5369:
4897:
4622:
4305:
3400:
3237:
2080:
171:
2194:
Pharmaceutical companies join the effort to develop and produce vaccines and treatments for the Ebola virus
1714:
Martínez-Romero C, García-Sastre A (November 2015). "Against the clock towards new Ebola virus therapies".
5731:
5660:
4659:
4361:
3759:
676:
In November 2019, the European Commission granted a conditional marketing authorization to Ervebo and the
2114:
1964:, claiming priority to US provisional patent application serial number 60/398,552 filed on July 26, 2003.
5848:
5726:
5560:
5555:
5011:
4957:
4867:
4518:
4412:
4366:
4235:
4066:
3547:
3528:
2731:
2698:
2496:
2278:
1617:
5609:
5550:
5341:
4984:
4862:
4813:
4780:
4714:
4258:
3990:
3356:
707:
389:
455:, the Ministry of Health approved the vaccine's emergency use, but it was not immediately deployed.
5532:
5498:
5384:
5150:
5145:
5096:
4927:
4795:
4767:
4719:
4340:
3907:
3633:
3593:
3523:
3518:
3408:
560:
440:
370:
273:
47:
4325:
1470:"Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses"
5565:
5399:
5140:
5091:
4967:
4937:
4857:
4775:
4543:
4206:
4189:
3779:
1999:
1774:
1499:
1436:
1217:
Marzi A, Ebihara H, Callison J, Groseth A, Williams KJ, Geisbert TW, Feldmann H (November 2011).
416:
4173:
4156:
609:
in which close contacts of people who had contracted Ebola virus were vaccinated with VSV-EBOV.
116:
730:
722:
5688:
5655:
5634:
5488:
5329:
5219:
5113:
4974:
4799:
4762:
4652:
4602:
4310:
4103:
3799:
3774:
3488:
3291:
3258:
Marzi A, Robertson SJ, Haddock E, Feldmann F, Hanley PW, Scott DP, et al. (August 2015).
2594:
2553:
2543:
2411:
1991:
1872:
1823:
1766:
1731:
1491:
1302:
1269:
Choi MJ, Cossaboom CM, Whitesell AN, Dyal JW, Joyce A, Morgan RL, et al. (January 2021).
1248:
1119:
1063:
1028:
851:
833:
737:
funding remains Merck's, and cannot be used by anyone else wishing to develop a rVSV vaccine.
392:. It consists of rice-derived recombinant human serum albumin and live attenuated recombinant
246:
229:
88:
1841:
Regules JA, Beigel JH, Paolino KM, Voell J, Castellano AR, Hu Z, et al. (January 2017).
1468:
Jones SM, Feldmann H, Ströher U, Geisbert JB, Fernando L, Grolla A, et al. (July 2005).
471:
vaccine had been 97.5% effective at stopping Ebola transmission, relative to no vaccination.
282:
5614:
5599:
5455:
5316:
5229:
4356:
4315:
3859:
3601:
3573:
3553:
3463:
3281:
3271:
2994:
2584:
2535:
2401:
2391:
1983:
1862:
1854:
1813:
1805:
1758:
1723:
1691:
1656:
1481:
1292:
1282:
1238:
1230:
1109:
1099:
1055:
1018:
1008:
995:
Trad MA, Naughton W, Yeung A, Mazlin L, O'sullivan M, Gilroy N, et al. (January 2017).
823:
813:
726:
606:
424:
401:
378:
374:
962:
338:
5795:
5619:
5417:
5224:
5182:
5053:
5023:
5006:
4932:
4922:
4852:
4791:
4787:
4736:
4503:
4392:
4371:
3839:
3831:
3794:
3789:
3338:
2468:
2307:
2200:
1950:
1918:
1897:
800:
Monath TP, Fast PE, Modjarrad K, Clarke DK, Martin BK, Fusco J, et al. (April 2019).
703:
659:
489:
405:
385:
76:
1219:"Vesicular stomatitis virus-based Ebola vaccines with improved cross-protective efficacy"
695:
similar to those among individuals in the studies conducted in Liberia and Sierra Leone.
3317:
3286:
3165:"Statement on disruptions to the Ebola response in the Democratic Republic of the Congo"
5823:
5807:
5756:
5483:
5374:
5334:
5214:
5040:
4979:
4558:
4300:
4281:
3849:
3804:
3764:
3493:
2406:
2244:
1867:
1842:
1818:
1793:
1297:
1270:
1243:
1218:
828:
599:
591:
584:
520:
428:
2589:
2572:
1961:
1762:
926:"Ervebo (zaire ebolavirus- strain kikwit-95 envelope glycoprotein injection, solution"
5817:
5639:
5624:
5594:
5589:
5444:
5207:
5202:
5197:
5192:
5101:
4947:
4746:
4508:
4422:
4335:
3996:
3784:
3742:
3714:
3691:
3628:
3134:
2883:
1395:
1382:
1317:
889:
718:
613:
563:) against corresponding infections with the otherwise typically lethal EBOV or MARV.
468:
366:
178:
2896:
2003:
1778:
748:
5716:
5359:
5254:
5187:
5128:
4952:
4808:
4699:
4679:
4548:
4447:
4330:
4320:
4140:
4124:
4108:
4046:
3932:
3825:
3769:
3561:
2791:"WHO prequalifies Ebola vaccine, paving the way for its use in high-risk countries"
1727:
1503:
496:
397:
198:
193:
33:
2396:
2379:
2022:"Canada urged to cancel Ebola vaccine licence, transfer rights to bigger company"
1146:"As Ebola outbreak rages, vaccine is 97.5% effective, protecting over 90K people"
1104:
1087:
5503:
5493:
5354:
5160:
5155:
5073:
5048:
5016:
4942:
4804:
4695:
4687:
4608:
4523:
4477:
4472:
4457:
4452:
4442:
4417:
4019:
3917:
3681:
3638:
3623:
3579:
3380:
997:"Ebola virus disease: An update on current prevention and management strategies"
818:
801:
2989:"Weekly Bulletin on Outbreak and other Emergencies: Week 26: 23–29 June 2018".
1059:
5629:
5604:
5294:
5244:
4538:
4533:
4528:
4487:
4482:
4437:
4397:
4376:
4086:
4001:
3868:
3752:
3696:
3663:
3390:
1660:
1585:"WHO coordinating vaccination of contacts to contain Ebola flare-up in Guinea"
1013:
996:
595:
313:
2463:
1809:
1749:
Shuchman M (May 2015). "Ebola vaccine trial in west Africa faces criticism".
423:(PHAC). PHAC licensed it to a small company, Newlink Genetics, which started
17:
5678:
5249:
5122:
4691:
4513:
4462:
4427:
4407:
4402:
4250:
3673:
3276:
3259:
2137:"Exclusive: Canada to donate its own Ebola vaccine to WHO for use in Africa"
1234:
532:
524:
110:
41:
3295:
2598:
2557:
2415:
1995:
1876:
1827:
1770:
1735:
1495:
1306:
1287:
1252:
1123:
1067:
1032:
837:
467:, into the effectiveness of the ring vaccination program, stating that the
2532:
Integrating Clinical Research Into Epidemic Response: The Ebola Experience
1858:
5520:
5513:
5508:
5478:
5234:
5170:
5165:
4553:
4432:
2497:"Vaccines alliance signs $ 5 million advance deal for Merck's Ebola shot"
1114:
511:
501:
432:
293:
155:
2999:
2214:"Canadian Ebola vaccine safety trials move ahead, NewLink Genetics says"
1696:
1023:
302:
5239:
5001:
4683:
4071:
4029:
4024:
3877:
3653:
3648:
3643:
2241:"Canadian Ebola vaccine license holder moving ahead with safety trials"
1987:
528:
142:
71:
56:
5802:
1974:
Baize S (July 2005). "A single shot against Ebola and Marburg virus".
5542:
5527:
4818:
3668:
1088:"Immunomonitoring of human responses to the rVSV-ZEBOV Ebola vaccine"
1046:
Pavot V (December 2016). "Ebola virus vaccines: Where do we stand?".
516:
2378:
Medaglini D, Harandi AM, Ottenhoff TH, Siegrist CA (December 2015).
2055:"Ebola outbreak: 1st human trials of Canadian vaccine start in U.S."
687:
In December 2019, Ervebo was approved for use in the United States.
2539:
1486:
1469:
5537:
5422:
5028:
4962:
3686:
3658:
755:: Number of rVSV-ZEBOV vaccinated persons in the epidemic area DRC
747:
542:
2882:
This article incorporates text from this source, which is in the
1794:"Progress of vaccine and drug development for Ebola preparedness"
1381:
This article incorporates text from this source, which is in the
1316:
This article incorporates text from this source, which is in the
396:(VSV), which has been genetically engineered to express the main
4837:
1552:"Fear and failure: How Ebola sparked a global health revolution"
734:
717:
Merck discontinued development of the related rVSV vaccines for
681:
506:
252:
133:
4648:
4254:
3352:
2993:. World Health Organization, Regional Office for Africa. 2018.
240:
150:
3348:
2932:
1555:
598:
in some people, and the vaccine was found replicating in the
453:
new outbreak of Ebola in the Democratic Republic of the Congo
2824:"MSF's response to CEPI's policy regarding equitable access"
1521:"Merck & Co. Licenses NewLink's Ebola Vaccine Candidate"
702:
The application for Ervebo in the United States was granted
583:
2014, Newlink exclusively licensed rights to the vaccine to
2430:"Q&A on trial of Ebola Virus Disease vaccine in Guinea"
1942:
Zachary Brennan for BioPharma Reporter. November 25, 2014.
1618:"Congo approves use of Ebola vaccination to fight outbreak"
714:(FDA) granted approval for Ervebo to Merck & Co., Inc.
2301:
FAQs about the context of this clinical trial: Question 10
1891:
FAQs about the context of this clinical trial: Question 22
760:
2018 Democratic Republic of the Congo Ebola virus outbreak
3969:
2023 Marburg virus disease outbreak in Equatorial Guinea
2991:
Weekly Bulletin on Outbreaks and Other Emergencies: 1–23
2353:"Canadian Ebola vaccine development taken over by Merck"
1843:"A Recombinant Vesicular Stomatitis Virus Ebola Vaccine"
766:
outbreak in the Democratic Republic of the Congo in 2018
590:
The Phase I study started with a high dose which caused
351:
Recombinant vesicular stomatitis virus–Zaire Ebola virus
224:
3199:"Congo declares new Ebola outbreak in eastern province"
2614:"Ebola vaccine highly effective in final trial results"
5779:
2275:
National Institute of Allergy and Infectious Diseases
2573:"First Ebola virus vaccine to protect human beings?"
2168:"Fact Sheet - VSV-EBOV - Canada's vaccine for Ebola"
1649:"Ebola vaccine approved for use in ongoing outbreak"
1179:
1177:
1175:
1173:
1171:
5709:
5648:
5580:
5471:
5443:
5410:
5084:
4915:
4908:
4827:
4755:
4707:
4587:
4571:
4496:
4385:
4349:
4288:
4198:
4187:
4165:
4154:
4133:
4122:
4095:
4084:
4059:
4038:
4012:
3982:
3941:
3930:
3900:
3815:
3730:
3707:
3616:
3539:
3399:
3388:
2380:"Ebola vaccine R&D: Filling the knowledge gaps"
2083:. Public Health Agency of Canada. October 6, 2014.
1944:
Merck to manufacture NewLink Ebola vaccine in-house
1930:Carly Helfand for FierceVaccine. November 21, 2014
328:
312:
292:
272:
267:
214:
209:
184:
170:
123:
105:
97:
87:
82:
70:
62:
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2853:
2534:. Washington (DC): National Academies Press (US).
1792:Choi WY, Hong KJ, Hong JE, Lee WJ (January 2015).
1709:
1707:
920:
918:
916:
914:
912:
706:, a tropical disease priority review voucher, and
5695:Cedillo v. Secretary of Health and Human Services
2666:"Major milestone for WHO-supported Ebola vaccine"
2166:Public Health Agency of Canada (August 2, 2013).
1579:
1577:
1432:"Ebola Vaccine, Ready for Test, Sat on the Shelf"
3233:"Scientists hail '100% effective' Ebola vaccine"
3076:"Media Advisory: Expected end of Ebola outbreak"
3046:"Congo Ebola Outbreak Expected to End Next Week"
1932:NewLink, Merck sign Ebola vaccine licensing pact
1264:
1262:
1139:
1137:
1135:
1133:
495:(VSV) in which the gene for the native envelope
3974:2023 Marburg virus disease outbreak in Tanzania
1081:
1079:
1077:
465:Institut National pour la Recherche Biomedicale
281:
2192:Patricia Van Arnum for DCAT. October 21, 2014
2057:CBC News. Associated Press. October 13, 2014.
1907:
1905:
1425:
1423:
1421:
4660:
4266:
3959:2021 Marburg virus disease outbreak in Guinea
3364:
1921:By Thomas Walkom, The Star, November 25, 2014
1185:Ebola Ring Vaccination Results April 12, 2019
957:
955:
953:
951:
439:, and has since been used extensively in the
8:
3964:2022 Marburg virus disease outbreak in Ghana
1525:Genetic Engineering & Biotechnology News
1463:
1461:
1459:
427:the vaccine; Newlink in turn licensed it to
159:
32:
3949:1967 Marburg virus outbreak in West Germany
3419:2013−2016 West African Ebola virus epidemic
2767:(Press release). Merck. November 11, 2019.
2464:"Ebola vaccine is 'potential game-changer'"
260:In general: ℞ (Prescription only)
4912:
4667:
4653:
4645:
4493:
4273:
4259:
4251:
4195:
4162:
4130:
4092:
3938:
3396:
3371:
3357:
3349:
2928:"Congo to begin vaccinating against Ebola"
2524:
2522:
2495:Hirshler B, Kelland K (January 20, 2016).
1798:Clinical and Experimental Vaccine Research
1515:
1513:
1350:
1348:
1346:
857:Centers for Disease Control and Prevention
40:
3341:at the U.S. National Library of Medicine
3285:
3275:
3241:. England. August 3, 2015. Archived from
2998:
2588:
2405:
2395:
2015:
2013:
1866:
1817:
1695:
1485:
1344:
1342:
1340:
1338:
1336:
1334:
1332:
1330:
1328:
1326:
1296:
1286:
1242:
1113:
1103:
1022:
1012:
852:"Ebola Vaccine: Information about Ervebo"
827:
817:
337:
3500:Recent DR Congo outbreaks and epidemics
2828:Médecins Sans Frontières Access Campaign
2699:"First vaccine to protect against Ebola"
2277:(NIAID). October 9, 2014. Archived from
631:In April 2017, scientists from the U.S.
5786:
3892:(2019 miniseries based on Preston book)
2049:
2047:
2032:from the original on September 29, 2015
1628:from the original on September 27, 2018
1402:(FDA). December 19, 2019. STN: 125690.
1086:Medaglini D, Siegrist CA (April 2017).
792:
527:, which Merck already used to make its
301:
3913:Ebola virus disease treatment research
3178:from the original on December 29, 2018
3145:from the original on November 11, 2019
2940:from the original on November 25, 2018
2804:from the original on November 15, 2019
2771:from the original on November 11, 2019
2745:from the original on November 15, 2019
2712:from the original on November 11, 2019
2679:from the original on November 11, 2019
2476:from the original on December 30, 2019
2061:from the original on November 20, 2019
1366:from the original on December 20, 2019
1156:from the original on February 19, 2021
684:to procure vaccine for distributions.
443:, with over 90,000 people vaccinated.
31:
4596:Merck Manual of Diagnosis and Therapy
2220:from the original on December 4, 2016
1667:from the original on January 20, 2020
1198:from the original on November 6, 2022
639:. The committee found that under an
115:
7:
4225:
2800:(Press release). November 12, 2019.
1562:from the original on August 26, 2019
885:"Summary Basis of Decision - Ervebo"
587:for US $ 50 million plus royalties.
197:
3025:from the original on April 14, 2021
2970:from the original on April 22, 2020
2834:from the original on March 21, 2021
2708:(Press release). October 18, 2019.
2675:(Press release). October 18, 2019.
2646:(Press release). September 17, 2019
2624:from the original on April 17, 2020
2174:from the original on April 22, 2020
2113:(WHO). January 2015. Archived from
1847:The New England Journal of Medicine
1527:. November 24, 2014. Archived from
1406:from the original on April 29, 2020
897:from the original on April 25, 2023
865:from the original on April 16, 2021
671:conditional marketing authorization
101:V920, rVSVΔG-ZEBOV-GP Ebola vaccine
27:Vaccine against Ebola virus disease
5834:Drugs developed by Merck & Co.
5722:Eradication of infectious diseases
5479:Androvax (androstenedione albumin)
3954:2017 Uganda Marburg virus outbreak
3439:United Nations Ebola Response Fund
3209:from the original on June 24, 2020
3086:from the original on July 23, 2018
3056:from the original on July 17, 2018
2907:from the original on June 24, 2020
2612:Schnirring L (December 27, 2016).
2359:from the original on April 2, 2018
2299:Hôpitaux Universitaires de Genève
2147:from the original on June 30, 2020
2107:Origins of the 2014 Ebola epidemic
2087:from the original on July 22, 2017
1889:Hôpitaux Universitaires de Genève
1690:(WHO) Regional Office for Africa.
1444:from the original on June 14, 2020
1223:The Journal of Infectious Diseases
976:from the original on March 8, 2021
936:from the original on March 5, 2023
437:2018 outbreak in Équateur province
25:
5844:West African Ebola virus epidemic
5312:Respiratory syncytial virus (RSV)
2507:from the original on July 5, 2019
1598:from the original on May 11, 2020
1275:MMWR. Recommendations and Reports
505:) is replaced with that from the
488:rVSV-ZEBOV is a live, attenuated
5801:
5789:
5701:Alternative vaccination schedule
4676:Artificial induction of immunity
4234:
4224:
3310:
2877:
2320:Table of vaccine clinical trials
2020:Branswell H (October 20, 2014).
1376:
1311:
413:National Microbiology Laboratory
404:so as to provoke a neutralizing
2439:. July 17, 2015. Archived from
2239:Branswell H (October 8, 2014).
2212:Branswell H (October 8, 2014).
673:for the rVSV-ZEBOV-GP vaccine.
569:Defense Threat Reduction Agency
419:, Canada, which is part of the
5533:Ovandrotone albumin (Fecundin)
2384:Science Translational Medicine
2355:. Reuters. November 24, 2014.
1728:10.1016/j.virusres.2015.05.025
557:Public Health Agency of Canada
421:Public Health Agency of Canada
361:and sold under the brand name
1:
5069:Group B streptococcal disease
4888:Vaccines for Children Program
2590:10.1016/S0140-6736(16)32618-6
2571:Geisbert TW (February 2017).
2462:Gallagher J (July 31, 2015).
1763:10.1016/S0140-6736(15)60938-2
656:Biologics License Application
3197:Mahamba F (August 1, 2018).
2865:Food and Drug Administration
2861:"FDA Roundup: July 28, 2023"
2530:Mancher M, Busta ER (eds.).
2397:10.1126/scitranslmed.aad3106
1430:Grady D (October 23, 2014).
1400:Food and Drug Administration
1360:Food and Drug Administration
1105:10.1016/j.coviro.2017.03.008
1001:Journal of Clinical Virology
712:Food and Drug Administration
652:Food and Drug Administration
633:National Academy of Medicine
431:in 2014. It was used in the
4579:Merck Headquarters Building
3748:Jean-Jacques Muyembe-Tamfum
3444:Operation United Assistance
3044:Schlein L (July 17, 2018).
1550:McKenzie D (May 26, 2018).
1092:Current Opinion in Virology
819:10.1016/j.jvacx.2019.100009
669:(EMA) recommended granting
641:intention-to-treat analysis
576:largest-ever Ebola epidemic
555:Scientists working for the
441:2018–20 Kivu Ebola outbreak
5865:
2779:– via Business Wire.
2654:– via Business Wire.
1917:November 26, 2014, at the
1896:November 16, 2018, at the
1362:(FDA). December 19, 2019.
1194:(Report). April 12, 2019.
1060:10.1016/j.clim.2016.10.016
650:In September 2019, the US
493:vesicular stomatitis virus
394:vesicular stomatitis virus
5740:
4220:
3429:Reported cases and deaths
3170:World Health Organization
3139:us13.campaign-archive.com
3111:World Health Organization
2964:us13.campaign-archive.com
2901:us13.campaign-archive.com
2796:World Health Organization
2737:European Medicines Agency
2704:European Medicines Agency
2671:World Health Organization
2435:World Health Organization
2325:World Health Organization
2306:October 30, 2019, at the
2199:February 4, 2016, at the
2111:World Health Organization
1688:World Health Organization
1661:10.1038/nature.2017.22024
1590:World Health Organization
1190:World Health Organization
1144:Mole B (April 16, 2019).
1014:10.1016/j.jcv.2016.11.005
968:European Medicines Agency
678:World Health Organization
667:European Medicines Agency
622:World Health Organization
369:for adults that prevents
39:
5064:Clostridioides difficile
3343:Medical Subject Headings
2329:(Report). Archived from
1949:August 29, 2021, at the
1810:10.7774/cevr.2015.4.1.11
1229:(Suppl 3): S1066–S1074.
772:2018 Kivu Ebola outbreak
753:2018 Kivu Ebola outbreak
549:West African Ebola virus
388:, replication-competent
359:Ebola Zaire vaccine live
5322:Tick-borne encephalitis
3277:10.1126/science.aab3920
3238:National Health Service
654:(FDA) accepted Merck's
5732:List of vaccine topics
4732:Mathematical modelling
4362:Cubist Pharmaceuticals
2863:(Press release). U.S.
2830:. September 25, 2018.
1358:(Press release). U.S.
1288:10.15585/mmwr.rr7001a1
776:On August 1, 2018, an
756:
574:In December 2013, the
552:
5839:Viral vector vaccines
5829:Health in West Africa
5727:Vaccinate Your Family
5178:Japanese encephalitis
4519:Ezetimibe/simvastatin
4413:Ezetimibe/simvastatin
4367:H. K. Mulford Company
4282:Merck & Co., Inc.
4207:Huangjiao thamnovirus
4067:Marburg virus disease
3588:Taï Forest ebolavirus
3548:Bundibugyo ebolavirus
1859:10.1056/NEJMoa1414216
1235:10.1093/infdis/jir348
861:. February 26, 2020.
751:
665:In October 2019, the
612:In January 2016, the
571:to develop vaccines.
546:
5610:John Franklin Enders
3991:Marburg marburgvirus
3245:on November 15, 2019
2867:(FDA). July 28, 2023
2741:. October 17, 2019.
2443:on November 15, 2019
972:. October 16, 2019.
710:designation. The US
708:breakthrough therapy
561:crab-eating macaques
408:to the Ebola virus.
390:viral vector vaccine
4796:Virus-like particle
4720:Vaccine ingredients
4289:Corporate directors
3908:Ebola virus disease
3414:1976 Zaire outbreak
3409:1976 Sudan outbreak
2333:on October 22, 2015
2281:on October 17, 2014
2251:on October 12, 2014
2143:. August 12, 2014.
2117:on January 20, 2015
1757:(9981): 1933–1934.
1048:Clinical Immunology
57:Vaccine description
48:electron micrograph
36:
5767:Never to phase III
5566:Hexavalent vaccine
5380:Epstein–Barr virus
5275:Oxford–AstraZeneca
4968:NmVac4-A/C/Y/W-135
4544:Rocuronium bromide
4468:rVSV-ZEBOV vaccine
3780:Thomas Eric Duncan
3328:RVSV-ZEBOV vaccine
2583:(10068): 479–480.
1988:10.1038/nm0705-720
1437:The New York Times
893:. March 24, 2023.
757:
553:
417:Winnipeg, Manitoba
77:Recombinant vector
50:of the Ebola virus
34:rVSV-ZEBOV vaccine
5777:
5776:
5689:Vaccines and SIDS
5576:
5575:
5350:Hepatitis A and B
5326:Varicella zoster
4788:Subunit/component
4642:
4641:
4603:The Merck Manuals
4567:
4566:
4248:
4247:
4216:
4215:
4183:
4182:
4174:Xilang striavirus
4150:
4149:
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4117:
4104:Lloviu cuevavirus
4080:
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3926:
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3775:Pauline Cafferkey
3738:Ebola researchers
3678:
3562:Reston ebolavirus
3489:Ouse to Ouse Tock
3270:(6249): 739–742.
3082:. July 23, 2018.
3021:. June 29, 2018.
2549:978-0-309-45776-7
1647:Maxmen A (2017).
932:. March 7, 2023.
662:for the vaccine.
357:), also known as
348:
347:
256:
244:
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16:(Redirected from
5856:
5806:
5805:
5794:
5793:
5792:
5785:
5668:MMR autism fraud
5615:Maurice Hilleman
5600:Hilary Koprowski
4913:
4669:
4662:
4655:
4646:
4494:
4357:Acceleron Pharma
4316:Rochelle Lazarus
4306:William Harrison
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3865:
3860:Executive Orders
3855:
3845:
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3602:Zaire ebolavirus
3574:Sudan ebolavirus
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2247:. Archived from
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1624:. May 29, 2017.
1614:
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727:Sudan ebolavirus
619:
607:ring vaccination
531:vaccine against
514:
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402:Zaire ebolavirus
384:rVSV-ZEBOV is a
379:ring vaccination
375:Zaire ebolavirus
341:
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5790:
5788:
5780:
5778:
5773:
5772:
5757:Clinical trials
5736:
5705:
5644:
5620:Stanley Plotkin
5582:
5572:
5484:Cancer vaccines
5467:
5461:Schistosomiasis
5439:
5433:Trypanosomiasis
5406:
5370:Cytomegalovirus
5280:Pfizer–BioNTech
5080:
4904:
4853:Vaccine wastage
4823:
4751:
4703:
4673:
4643:
4638:
4583:
4563:
4504:Coppertone sign
4497:Schering-Plough
4492:
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4372:Schering-Plough
4345:
4284:
4279:
4249:
4244:
4212:
4179:
4146:
4114:
4076:
4055:
4050:
4039:Popular culture
4034:
4013:Drug candidates
4008:
3978:
3922:
3896:
3891:
3881:
3871:
3863:
3853:
3843:
3832:Richard Preston
3829:
3817:Popular culture
3811:
3795:Matthew Lukwiya
3790:Sheik Umar Khan
3726:
3703:
3617:Drug candidates
3612:
3535:
3529:2021 North Kivu
3469:in Sierra Leone
3384:
3377:
3335:
3334:
3333:
3315:
3311:
3306:
3257:
3248:
3246:
3231:
3228:
3226:Further reading
3223:
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3179:
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3118:
3116:
3115:(Press release)
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2308:Wayback Machine
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2100:
2090:
2088:
2079:
2078:
2074:
2064:
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2052:
2045:
2035:
2033:
2019:
2018:
2011:
1976:Nature Medicine
1973:
1972:
1968:
1960:
1956:
1951:Wayback Machine
1941:
1937:
1929:
1925:
1919:Wayback Machine
1910:
1903:
1898:Wayback Machine
1888:
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1840:
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1641:
1631:
1629:
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1611:
1601:
1599:
1583:
1582:
1575:
1565:
1563:
1549:
1548:
1544:
1534:
1532:
1531:on May 18, 2018
1519:
1518:
1511:
1474:Nature Medicine
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1199:
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1131:
1085:
1084:
1075:
1045:
1044:
1040:
994:
993:
989:
979:
977:
961:
960:
949:
939:
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924:
923:
910:
900:
898:
883:
882:
878:
868:
866:
850:
849:
845:
799:
798:
794:
789:
774:
762:
746:
704:priority review
660:priority review
617:
547:Area where the
541:
510:
500:
486:
477:
461:
449:
406:immune response
377:. When used in
344:
324:
308:
288:
263:
233:
205:
173:
166:
51:
28:
23:
22:
15:
12:
11:
5:
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5860:
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5851:
5846:
5841:
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5810:
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5775:
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5738:
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5729:
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5650:
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5645:
5643:
5642:
5637:
5635:Katalin Karikó
5632:
5627:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5586:
5584:
5578:
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5425:
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5407:
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5404:
5403:
5402:
5397:
5392:
5390:Herpes simplex
5387:
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5364:
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5362:
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5339:
5338:
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5332:
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5319:
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5308:
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5297:
5292:
5290:Sinopharm BIBP
5287:
5282:
5277:
5272:
5267:
5262:
5257:
5252:
5247:
5242:
5240:Bharat Biotech
5237:
5227:
5222:
5217:
5212:
5211:
5210:
5205:
5195:
5190:
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4871:
4870:
4868:Vaccine injury
4865:
4860:
4855:
4850:
4845:
4840:
4831:
4829:
4828:Administration
4825:
4824:
4822:
4821:
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4802:
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4784:
4783:
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4627:
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4585:
4584:
4582:
4581:
4575:
4573:
4569:
4568:
4565:
4564:
4562:
4561:
4559:Urofollitropin
4556:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4500:
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4430:
4425:
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4346:
4344:
4343:
4338:
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4328:
4323:
4318:
4313:
4311:William Kelley
4308:
4303:
4301:Johnnetta Cole
4298:
4292:
4290:
4286:
4285:
4280:
4278:
4277:
4270:
4263:
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4246:
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4081:
4078:
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4069:
4063:
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4053:
4042:
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4036:
4035:
4033:
4032:
4027:
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3979:
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3976:
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3951:
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3943:
3936:
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3927:
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3923:
3921:
3920:
3915:
3910:
3904:
3902:
3898:
3897:
3895:
3894:
3884:
3874:
3866:
3856:
3850:Ebola Syndrome
3846:
3836:
3830:(1995 book by
3821:
3819:
3813:
3812:
3810:
3809:
3808:
3807:
3805:Patrick Sawyer
3802:
3800:Mayinga N'Seka
3797:
3792:
3787:
3782:
3777:
3772:
3767:
3765:Ameyo Adadevoh
3760:Ebola patients
3757:
3756:
3755:
3750:
3745:
3734:
3732:
3731:Notable people
3728:
3727:
3725:
3724:
3723:
3722:
3711:
3709:
3705:
3704:
3702:
3701:
3700:
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3684:
3679:
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3661:
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3636:
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3626:
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3613:
3611:
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3609:
3608:
3598:
3597:
3596:
3584:
3583:
3582:
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3569:
3568:
3558:
3557:
3556:
3543:
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3537:
3536:
3534:
3533:
3532:
3531:
3526:
3521:
3516:
3511:
3506:
3498:
3497:
3496:
3494:Womey massacre
3491:
3486:
3481:
3476:
3471:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3416:
3411:
3405:
3403:
3394:
3386:
3385:
3378:
3376:
3375:
3368:
3361:
3353:
3347:
3346:
3339:Ebola Vaccines
3316:
3309:
3308:
3307:
3305:
3304:External links
3302:
3301:
3300:
3255:
3227:
3224:
3221:
3220:
3189:
3156:
3126:
3097:
3067:
3036:
3006:
2981:
2951:
2918:
2888:
2849:
2815:
2782:
2756:
2723:
2690:
2657:
2635:
2604:
2563:
2548:
2540:10.17226/24739
2518:
2487:
2454:
2421:
2370:
2344:
2311:
2292:
2262:
2245:Canadian Press
2231:
2204:
2185:
2158:
2128:
2098:
2072:
2043:
2009:
1982:(7): 720–721.
1966:
1954:
1935:
1923:
1901:
1882:
1853:(4): 330–341.
1833:
1784:
1741:
1716:Virus Research
1703:
1678:
1639:
1609:
1594:. March 2016.
1573:
1542:
1509:
1487:10.1038/nm1258
1480:(7): 786–790.
1455:
1417:
1387:
1322:
1258:
1209:
1167:
1129:
1073:
1038:
987:
947:
908:
876:
843:
791:
790:
788:
785:
773:
770:
761:
758:
745:
742:
600:synovial fluid
596:skin reactions
540:
537:
525:Vero cell line
485:
482:
476:
473:
460:
457:
448:
445:
373:caused by the
346:
345:
343:
342:
334:
332:
326:
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323:
322:
318:
316:
310:
309:
307:
306:
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289:
287:
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278:
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270:
269:
265:
264:
262:
261:
258:
249:
237:
236:Schedule D<
220:
218:
212:
211:
207:
206:
204:
203:
190:
188:
182:
181:
176:
174:administration
168:
167:
165:
164:
147:
129:
127:
121:
120:
113:
103:
102:
99:
95:
94:
91:
85:
84:
80:
79:
74:
68:
67:
64:
60:
59:
53:
52:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
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5850:
5847:
5845:
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5837:
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5832:
5830:
5827:
5825:
5822:
5821:
5819:
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5799:
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5787:
5783:
5766:
5764:
5761:
5760:
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5755:
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5669:
5667:
5662:
5659:
5657:
5654:
5653:
5651:
5647:
5641:
5640:Drew Weissman
5638:
5636:
5633:
5631:
5628:
5626:
5625:H. Fred Clark
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5595:Louis Pasteur
5593:
5591:
5590:Edward Jenner
5588:
5587:
5585:
5579:
5567:
5564:
5562:
5561:DTwP-HepB-Hib
5559:
5557:
5556:DTaP-IPV-HepB
5554:
5552:
5549:
5548:
5547:combination:
5546:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5522:
5519:
5515:
5512:
5510:
5507:
5506:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5486:
5485:
5482:
5480:
5477:
5476:
5474:
5470:
5462:
5459:
5457:
5454:
5453:
5451:
5450:
5448:
5446:
5445:Helminthiasis
5442:
5434:
5431:
5430:
5428:
5424:
5421:
5420:
5419:
5416:
5415:
5413:
5409:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5383:
5381:
5378:
5376:
5373:
5371:
5368:
5367:
5365:
5361:
5358:
5356:
5353:
5351:
5348:
5347:
5346:combination:
5345:
5343:
5340:
5336:
5333:
5331:
5328:
5327:
5325:
5323:
5320:
5318:
5315:
5313:
5310:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5236:
5233:
5232:
5231:
5228:
5226:
5223:
5221:
5218:
5216:
5213:
5209:
5206:
5204:
5201:
5200:
5199:
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5194:
5191:
5189:
5186:
5184:
5181:
5179:
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5172:
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5164:
5163:
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5152:
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5142:
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5132:
5130:
5127:
5124:
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5117:
5116:
5115:
5112:
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5105:
5104:
5103:
5100:
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5095:
5093:
5090:
5089:
5087:
5083:
5075:
5072:
5070:
5067:
5065:
5062:
5061:
5059:
5055:
5052:
5050:
5049:DPT/DTwP/DTaP
5047:
5046:
5045:combination:
5044:
5042:
5039:
5035:
5032:
5030:
5027:
5026:
5025:
5022:
5018:
5015:
5014:
5013:
5010:
5008:
5005:
5003:
5000:
4996:
4993:
4991:
4988:
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4986:
4983:
4981:
4978:
4976:
4973:
4969:
4966:
4964:
4961:
4960:
4959:
4958:Meningococcus
4956:
4954:
4951:
4949:
4948:Leptospirosis
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4924:
4921:
4920:
4918:
4914:
4911:
4907:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4883:Vaccine court
4881:
4879:
4876:
4875:
4873:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4838:GAVI Alliance
4836:
4835:
4833:
4832:
4830:
4826:
4820:
4817:
4815:
4812:
4810:
4806:
4803:
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4658:
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4633:
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4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4509:Desloratadine
4507:
4505:
4502:
4501:
4499:
4495:
4489:
4486:
4484:
4481:
4479:
4476:
4474:
4471:
4469:
4466:
4464:
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4449:
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4429:
4426:
4424:
4423:Fosaprepitant
4421:
4419:
4416:
4414:
4411:
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4406:
4404:
4401:
4399:
4396:
4394:
4391:
4390:
4388:
4384:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4354:
4352:
4348:
4342:
4341:Peter Wendell
4339:
4337:
4336:Wendell Weeks
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4296:Richard Clark
4294:
4293:
4291:
4287:
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4276:
4271:
4269:
4264:
4262:
4257:
4256:
4253:
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4233:
4231:
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4219:
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4208:
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4203:
4201:
4197:
4194:
4192:
4191:
4186:
4176:
4175:
4171:
4170:
4168:
4164:
4161:
4159:
4158:
4153:
4142:
4139:
4138:
4136:
4132:
4129:
4127:
4126:
4121:
4110:
4106:
4105:
4101:
4100:
4098:
4094:
4091:
4089:
4088:
4083:
4073:
4070:
4068:
4065:
4064:
4062:
4060:Miscellaneous
4058:
4049:
4048:
4044:
4043:
4041:
4037:
4031:
4028:
4026:
4023:
4021:
4018:
4017:
4015:
4011:
4003:
4000:
3998:
3995:
3994:
3993:
3992:
3988:
3987:
3985:
3981:
3975:
3972:
3970:
3967:
3965:
3962:
3960:
3957:
3955:
3952:
3950:
3947:
3946:
3944:
3940:
3937:
3935:
3934:
3929:
3919:
3916:
3914:
3911:
3909:
3906:
3905:
3903:
3901:Miscellaneous
3899:
3890:
3889:
3885:
3880:
3879:
3875:
3870:
3867:
3862:
3861:
3857:
3852:
3851:
3847:
3842:
3841:
3837:
3833:
3828:
3827:
3823:
3822:
3820:
3818:
3814:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3785:Salome Karwah
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3762:
3761:
3758:
3754:
3751:
3749:
3746:
3744:
3743:William Close
3741:
3740:
3739:
3736:
3735:
3733:
3729:
3721:
3718:
3717:
3716:
3713:
3712:
3710:
3706:
3698:
3695:
3694:
3693:
3690:
3688:
3685:
3683:
3680:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3629:Brincidofovir
3627:
3625:
3622:
3621:
3619:
3615:
3606:
3605:
3604:
3603:
3599:
3595:
3592:
3591:
3590:
3589:
3585:
3581:
3578:
3577:
3576:
3575:
3571:
3566:
3565:
3564:
3563:
3559:
3555:
3552:
3551:
3550:
3549:
3545:
3544:
3542:
3538:
3530:
3527:
3525:
3524:2020 Équateur
3522:
3520:
3519:Kivu epidemic
3517:
3515:
3514:2018 Équateur
3512:
3510:
3507:
3505:
3502:
3501:
3499:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
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3445:
3442:
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3435:
3432:
3430:
3427:
3425:
3422:
3421:
3420:
3417:
3415:
3412:
3410:
3407:
3406:
3404:
3402:
3398:
3395:
3393:
3392:
3387:
3383:
3382:
3374:
3369:
3367:
3362:
3360:
3355:
3354:
3351:
3344:
3340:
3337:
3336:
3331:
3330:
3329:
3323:
3319:
3303:
3297:
3293:
3288:
3283:
3278:
3273:
3269:
3265:
3261:
3256:
3244:
3240:
3239:
3234:
3230:
3229:
3225:
3208:
3204:
3200:
3193:
3190:
3177:
3173:
3171:
3166:
3160:
3157:
3144:
3141:(in French).
3140:
3136:
3130:
3127:
3114:
3112:
3107:
3101:
3098:
3085:
3081:
3077:
3071:
3068:
3055:
3051:
3047:
3040:
3037:
3024:
3020:
3016:
3010:
3007:
3001:
2996:
2992:
2985:
2982:
2969:
2965:
2961:
2955:
2952:
2939:
2935:
2934:
2929:
2926:Berlinger J.
2922:
2919:
2906:
2902:
2898:
2892:
2889:
2885:
2884:public domain
2866:
2862:
2856:
2854:
2850:
2846:
2833:
2829:
2825:
2819:
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2803:
2799:
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2724:
2711:
2707:
2705:
2700:
2694:
2691:
2678:
2674:
2672:
2667:
2661:
2658:
2650:September 17,
2645:
2639:
2636:
2623:
2619:
2615:
2608:
2605:
2600:
2596:
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2315:
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2296:
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2280:
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2263:
2250:
2246:
2242:
2235:
2232:
2219:
2215:
2208:
2205:
2202:
2198:
2195:
2189:
2186:
2173:
2169:
2162:
2159:
2146:
2142:
2138:
2132:
2129:
2116:
2112:
2108:
2102:
2099:
2086:
2082:
2076:
2073:
2060:
2056:
2050:
2048:
2044:
2031:
2027:
2023:
2016:
2014:
2010:
2005:
2001:
1997:
1993:
1989:
1985:
1981:
1977:
1970:
1967:
1963:
1958:
1955:
1952:
1948:
1945:
1939:
1936:
1933:
1927:
1924:
1920:
1916:
1913:
1908:
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1902:
1899:
1895:
1892:
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1878:
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1869:
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1856:
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1811:
1807:
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1799:
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1764:
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1725:
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1717:
1710:
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1698:
1693:
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1679:
1666:
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1650:
1643:
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1627:
1623:
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1613:
1610:
1597:
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1574:
1561:
1557:
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1543:
1530:
1526:
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1516:
1514:
1510:
1505:
1501:
1497:
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1488:
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1471:
1464:
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1460:
1456:
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1438:
1433:
1426:
1424:
1422:
1418:
1405:
1401:
1397:
1391:
1388:
1384:
1383:public domain
1365:
1361:
1357:
1351:
1349:
1347:
1345:
1343:
1341:
1339:
1337:
1335:
1333:
1331:
1329:
1327:
1323:
1319:
1318:public domain
1308:
1304:
1299:
1294:
1289:
1284:
1280:
1276:
1272:
1265:
1263:
1259:
1254:
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1224:
1220:
1213:
1210:
1197:
1193:
1191:
1186:
1180:
1178:
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1174:
1172:
1168:
1155:
1151:
1147:
1140:
1138:
1136:
1134:
1130:
1125:
1121:
1116:
1115:11365/1135960
1111:
1106:
1101:
1097:
1093:
1089:
1082:
1080:
1078:
1074:
1069:
1065:
1061:
1057:
1053:
1049:
1042:
1039:
1034:
1030:
1025:
1020:
1015:
1010:
1006:
1002:
998:
991:
988:
975:
971:
969:
964:
963:"Ervebo EPAR"
958:
956:
954:
952:
948:
935:
931:
927:
921:
919:
917:
915:
913:
909:
896:
892:
891:
890:Health Canada
886:
880:
877:
864:
860:
858:
853:
847:
844:
839:
835:
830:
825:
820:
815:
811:
807:
803:
796:
793:
786:
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781:
779:
771:
769:
767:
759:
754:
750:
743:
741:
738:
736:
732:
728:
724:
720:
719:Marburg virus
715:
713:
709:
705:
700:
696:
692:
688:
685:
683:
679:
674:
672:
668:
663:
661:
657:
653:
648:
644:
642:
638:
634:
629:
625:
623:
618:US$ 5 million
615:
614:GAVI Alliance
610:
608:
603:
601:
597:
593:
588:
586:
580:
577:
572:
570:
564:
562:
558:
550:
545:
538:
536:
534:
530:
526:
522:
518:
513:
508:
503:
498:
494:
491:
483:
481:
474:
472:
470:
469:rVSV-ZEBOV-GP
466:
459:Effectiveness
458:
456:
454:
446:
444:
442:
438:
434:
430:
426:
422:
418:
414:
409:
407:
403:
399:
395:
391:
387:
382:
380:
376:
372:
368:
367:Ebola vaccine
364:
360:
356:
352:
340:
336:
335:
333:
331:
327:
320:
319:
317:
315:
311:
304:
300:
299:
297:
295:
291:
284:
280:
279:
277:
275:
271:
266:
259:
257: Rx-only
250:
248:
238:
231:
222:
221:
219:
217:
213:
208:
200:
195:
192:
191:
189:
187:
183:
180:
179:Intramuscular
177:
175:
169:
162:
157:
148:
145:
140:
131:
130:
128:
126:
122:
118:
114:
112:
108:
104:
100:
96:
92:
90:
86:
83:Clinical data
81:
78:
75:
73:
69:
65:
61:
58:
54:
49:
43:
38:
30:
19:
18:RVSV-ZEBOV-GP
5849:Orphan drugs
5717:Epidemiology
5693:
5665:
5551:DTaP-IPV/Hib
5342:Yellow fever
5255:EpiVacCorona
5106:
5012:Tuberculosis
4985:Pneumococcal
4953:Lyme disease
4781:Heterologous
4680:Immunization
4630:
4623:
4616:
4609:
4601:
4594:
4588:Publications
4549:Temozolomide
4467:
4448:Omarigliptin
4350:Subsidiaries
4331:Samuel Thier
4326:Anne Tatlock
4321:Thomas Shenk
4205:
4188:
4172:
4155:
4141:Mengla virus
4123:
4102:
4085:
4047:The Hot Zone
4045:
3989:
3933:Marburgvirus
3931:
3888:The Hot Zone
3886:
3876:
3864:(1996 novel)
3858:
3848:
3838:
3826:The Hot Zone
3824:
3770:Kent Brantly
3719:
3600:
3586:
3572:
3560:
3546:
3389:
3379:
3326:
3325:
3324:profile for
3321:
3267:
3263:
3249:November 15,
3247:. Retrieved
3243:the original
3236:
3211:. Retrieved
3202:
3192:
3180:. Retrieved
3168:
3159:
3147:. Retrieved
3138:
3129:
3117:. Retrieved
3109:
3100:
3088:. Retrieved
3079:
3070:
3058:. Retrieved
3049:
3039:
3027:. Retrieved
3018:
3009:
3000:10665/272981
2990:
2984:
2972:. Retrieved
2963:
2954:
2942:. Retrieved
2931:
2921:
2911:December 31,
2909:. Retrieved
2900:
2891:
2869:. Retrieved
2843:
2836:. Retrieved
2827:
2818:
2808:November 13,
2806:. Retrieved
2794:
2785:
2775:November 11,
2773:. Retrieved
2759:
2749:November 15,
2747:. Retrieved
2735:
2726:
2716:November 11,
2714:. Retrieved
2702:
2693:
2681:. Retrieved
2669:
2660:
2648:. Retrieved
2638:
2628:December 28,
2626:. Retrieved
2617:
2607:
2580:
2576:
2566:
2531:
2509:. Retrieved
2500:
2490:
2478:. Retrieved
2467:
2457:
2447:November 14,
2445:. Retrieved
2441:the original
2433:
2424:
2387:
2383:
2373:
2361:. Retrieved
2347:
2335:. Retrieved
2331:the original
2323:
2314:
2295:
2283:. Retrieved
2279:the original
2265:
2253:. Retrieved
2249:the original
2234:
2222:. Retrieved
2216:. CBC News.
2207:
2188:
2176:. Retrieved
2161:
2149:. Retrieved
2140:
2131:
2119:. Retrieved
2115:the original
2101:
2089:. Retrieved
2075:
2063:. Retrieved
2034:. Retrieved
2025:
1979:
1975:
1969:
1957:
1938:
1926:
1885:
1850:
1846:
1836:
1804:(1): 11–16.
1801:
1797:
1787:
1754:
1750:
1744:
1719:
1715:
1697:10665/255645
1681:
1669:. Retrieved
1652:
1642:
1630:. Retrieved
1621:
1612:
1600:. Retrieved
1588:
1564:. Retrieved
1545:
1533:. Retrieved
1529:the original
1524:
1477:
1473:
1448:December 21,
1446:. Retrieved
1435:
1408:. Retrieved
1390:
1370:December 19,
1368:. Retrieved
1278:
1274:
1226:
1222:
1212:
1200:. Retrieved
1188:
1158:. Retrieved
1150:Ars Technica
1149:
1095:
1091:
1051:
1047:
1041:
1024:10144/618818
1004:
1000:
990:
978:. Retrieved
966:
938:. Retrieved
929:
899:. Retrieved
888:
879:
867:. Retrieved
855:
846:
809:
805:
795:
782:
778:EVD outbreak
775:
763:
739:
716:
701:
697:
693:
689:
686:
675:
664:
658:and granted
649:
645:
637:underpowered
630:
626:
611:
604:
589:
581:
573:
565:
554:
548:
523:, using the
497:glycoprotein
487:
484:Biochemistry
478:
475:Side effects
462:
450:
410:
398:glycoprotein
383:
362:
358:
354:
350:
349:
283:2581749-86-0
216:Legal status
210:Legal status
125:License data
72:Vaccine type
29:
5753:from market
5649:Controversy
5583:researchers
5499:Hepatitis B
5385:Hepatitis C
5330:Chicken pox
5156:Hepatitis E
5151:Hepatitis B
5146:Hepatitis A
5097:Chikungunya
5074:Shigellosis
4928:Brucellosis
4814:Therapeutic
4768:Inactivated
4708:Development
4696:Inoculation
4688:Vaccination
4524:Famciclovir
4478:Sitagliptin
4473:Simvastatin
4458:Rizatriptan
4453:Raltegravir
4443:Montelukast
4418:Finasteride
4393:Alendronate
4240:Wikispecies
4190:Thamnovirus
4125:Dianlovirus
4051:(1995 book)
3918:Ebola River
3882:(2016 film)
3872:(2014 meme)
3854:(1996 film)
3844:(1995 film)
3682:Triazavirin
3639:Favipiravir
3381:Filoviridae
3029:January 30,
2683:October 19,
2511:January 20,
2363:January 10,
2337:October 14,
2285:October 13,
2255:October 13,
2224:October 21,
2178:January 10,
2151:January 10,
2065:October 13,
2036:January 10,
1535:January 20,
1281:(1): 1–12.
507:Ebola virus
490:recombinant
447:Medical use
386:recombinant
268:Identifiers
98:Other names
89:Trade names
66:Ebola virus
5818:Categories
5684:Thiomersal
5630:Paul Offit
5605:Jonas Salk
5581:Inventors/
5452:research:
5429:research:
5366:research:
5295:Skycovione
5285:Sanofi–GSK
5230:SARS-CoV-2
5141:Hantavirus
5107:rVSV-ZEBOV
5092:Adenovirus
5060:research:
4938:Diphtheria
4776:Attenuated
4631:Geriatrics
4624:Veterinary
4572:Facilities
4539:Mometasone
4534:Loratadine
4529:Infliximab
4488:Vorinostat
4483:Vericiguat
4438:Lovastatin
4398:Aprepitant
4377:Viralytics
4157:Striavirus
4087:Cuevavirus
3869:Ebola-chan
3753:Peter Piot
3720:rVSV-ZEBOV
3697:cAd3-ZEBOV
3664:Lamivudine
3464:in Nigeria
3454:in Liberia
3391:Ebolavirus
3213:January 5,
3182:January 5,
3149:January 5,
2121:October 8,
2109:(Report).
812:: 100009.
787:References
764:During an
744:Ebola 2018
425:developing
355:rVSV-ZEBOV
339:Y9VG7O3KTT
314:ChemSpider
274:CAS Number
5763:Phase III
5751:Withdrawn
5679:Pox party
5489:ALVAC-CEA
5411:Protozoan
5300:Sputnik V
5250:CoronaVac
5220:Rotavirus
5123:Pandemrix
4975:Pertussis
4916:Bacterial
4800:Synthetic
4763:Conjugate
4715:Adjuvants
4692:Infection
4514:Ezetimibe
4463:Rofecoxib
4428:Indinavir
4408:Ezetimibe
4403:Ertapenem
3942:Outbreaks
3674:TKM-Ebola
3484:in the UK
3479:in the US
3449:in Guinea
3434:Responses
3401:Outbreaks
3080:ReliefWeb
3019:ReliefWeb
2871:August 2,
2838:April 10,
2091:August 4,
1410:March 28,
1202:April 17,
1160:April 17,
1098:: 88–94.
1054:: 44–49.
980:March 29,
940:August 2,
901:April 24,
869:April 16,
731:rVSV-SUDV
723:rVSV-MARV
592:arthritis
533:rotavirus
400:from the
172:Routes of
117:Monograph
111:Drugs.com
5796:Medicine
5521:Prostvac
5514:Gardasil
5509:Cervarix
5456:Hookworm
5335:Shingles
5317:Smallpox
5235:Corbevax
5171:Gardasil
5166:Cervarix
4909:Vaccines
4863:Schedule
4834:Global:
4742:Timeline
4684:Vaccines
4554:Tibolone
4433:Losartan
4386:Products
3840:Outbreak
3715:Vaccines
3692:Vaccines
3677:(failed)
3474:in Spain
3424:Timeline
3296:26249231
3287:11040598
3207:Archived
3176:Archived
3143:Archived
3119:July 24,
3090:July 23,
3084:Archived
3060:July 17,
3054:Archived
3023:Archived
2968:Archived
2938:Archived
2905:Archived
2832:Archived
2802:Archived
2769:Archived
2743:Archived
2732:"Ervebo"
2710:Archived
2677:Archived
2622:Archived
2599:28017402
2558:28696651
2505:Archived
2480:July 30,
2474:Archived
2416:26659569
2357:Archived
2304:Archived
2218:Archived
2197:Archived
2172:Archived
2145:Archived
2085:Archived
2059:Archived
2030:Archived
2004:34226536
1996:16015361
1947:Archived
1915:Archived
1894:Archived
1877:25830322
1828:25648233
1779:40400570
1771:25979835
1736:26057711
1722:: 4–10.
1671:June 28,
1665:Archived
1626:Archived
1596:Archived
1560:Archived
1496:15937495
1442:Archived
1404:Archived
1396:"Ervebo"
1364:Archived
1307:33417593
1253:21987743
1196:Archived
1154:Archived
1124:28460340
1068:27910805
1033:27893999
1007:: 5–13.
974:Archived
934:Archived
930:DailyMed
895:Archived
863:Archived
838:31384731
433:DR Congo
365:, is an
294:DrugBank
186:ATC code
156:DailyMed
5808:Viruses
5782:Portals
5710:Related
5656:General
5418:Malaria
5305:Valneva
5270:Novavax
5265:Moderna
5260:Janssen
5245:CanSino
5225:Rubella
5183:Measles
5054:Td/Tdap
5024:Typhoid
5007:Tetanus
5002:Q fever
4933:Cholera
4923:Anthrax
4792:Peptide
4756:Classes
4737:Storage
4230:Commons
4199:Species
4166:Species
4134:Species
4096:Species
4072:Marburg
4030:FGI-106
4025:FGI-103
4020:BCX4430
3983:Species
3878:93 Days
3654:FGI-106
3649:FGI-104
3644:FGI-103
3624:BCX4430
3540:Species
3459:in Mali
3318:Scholia
3264:Science
3203:Reuters
2974:July 2,
2944:July 2,
2501:Reuters
2407:6858855
2141:Reuters
2026:CTVNews
1868:5408576
1819:4313103
1632:May 29,
1622:Reuters
1602:May 14,
1566:May 26,
1504:5450135
1398:. U.S.
1298:7802368
1244:3203393
829:6668225
806:Vaccine
539:History
529:RotaTeq
303:DB15595
232: /
228::
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196: (
194:J07BX02
158::
141::
5746:WHO-EM
5666:Lancet
5543:TA-NIC
5528:NicVAX
5375:Dengue
5215:Rabies
5041:Typhus
4980:Plague
4858:Policy
4819:Toxoid
4747:Trials
4617:Manual
4143:(MLAV)
3669:mAb114
3345:(MeSH)
3320:has a
3294:
3284:
2618:CIDRAP
2597:
2577:Lancet
2556:
2546:
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2414:
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2002:
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1865:
1826:
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1502:
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1066:
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517:Kikwit
512:P87666
502:P03522
363:Ervebo
247:℞-only
245:
234:
230:℞-only
161:Ervebo
154:
144:by INN
137:
93:Ervebo
63:Target
5824:Ebola
5674:NCVIA
5538:TA-CD
5472:Other
5423:RTS,S
5203:Sabin
5198:Polio
5193:Mumps
5102:Ebola
5085:Viral
5034:ViCPS
5029:Ty21a
4963:MeNZB
4893:VAERS
4843:NITAG
4772:Live
4610:Index
3708:Drugs
3687:ZMapp
3659:JK-05
3634:DZNep
3567:RESTV
3322:topic
3172:(WHO)
3113:(WHO)
2798:(WHO)
2739:(EMA)
2706:(EMA)
2673:(WHO)
2437:(WHO)
2327:(WHO)
2000:S2CID
1775:S2CID
1592:(WHO)
1500:S2CID
1192:(WHO)
970:(EMA)
859:(CDC)
585:Merck
521:Merck
435:in a
429:Merck
371:Ebola
5400:Zika
5360:MMRV
5208:Salk
5188:Mpox
5134:LAIV
5129:H5N1
5119:H1N1
4995:PPSV
4878:ACIP
4874:US:
4848:SAGE
4809:mRNA
4725:list
4109:LLOV
4002:RAVV
3997:MARV
3607:EBOV
3594:TAFV
3580:SUDV
3554:BDBV
3509:2017
3504:2014
3292:PMID
3251:2019
3215:2019
3184:2019
3151:2019
3121:2018
3092:2018
3062:2018
3031:2022
2976:2018
2946:2018
2913:2018
2873:2023
2840:2020
2810:2019
2777:2019
2751:2019
2718:2019
2685:2019
2652:2019
2630:2016
2595:PMID
2554:PMID
2544:ISBN
2513:2016
2482:2015
2449:2019
2412:PMID
2365:2020
2339:2016
2287:2014
2257:2014
2226:2014
2180:2020
2153:2020
2123:2016
2093:2015
2067:2014
2038:2020
1992:PMID
1873:PMID
1824:PMID
1767:PMID
1732:PMID
1673:2017
1634:2017
1604:2016
1568:2018
1537:2016
1492:PMID
1450:2019
1412:2020
1372:2019
1303:PMID
1249:PMID
1204:2019
1162:2019
1120:PMID
1064:PMID
1029:PMID
982:2020
942:2023
903:2023
871:2021
834:PMID
735:GAVI
682:GAVI
594:and
330:UNII
321:none
107:AHFS
5661:MMR
5504:HPV
5494:BCG
5395:HIV
5355:MMR
5161:HPV
5114:Flu
5017:BCG
4990:PCV
4943:Hib
4898:VSD
4805:DNA
4700:J07
3282:PMC
3272:doi
3268:349
3050:VOA
2995:hdl
2933:CNN
2585:doi
2581:389
2536:doi
2402:PMC
2392:doi
1984:doi
1863:PMC
1855:doi
1851:376
1814:PMC
1806:doi
1759:doi
1755:385
1724:doi
1720:209
1692:hdl
1657:doi
1556:CNN
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1227:204
1110:hdl
1100:doi
1056:doi
1052:173
1019:hdl
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