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found in platelets and helps in strengthening blood clots during their formation. Polyphosphates housed inside platelets break up during clotting. These polyphosphates and other components get released to form a mesh that constitutes the basic structure for clot. Lowering IP7 levels could have potential applications in the prevention of stroke or myocardial infarction by reducing clotting.
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In 2015, a group led by
Bhandari found that mice with lower levels of IP7 show reduced blood clotting. Inadequate levels of IP7 led to reduction in another phosphate-rich molecule called polyphosphate (a long chain of phosphate groups linked to each other). In mammals, polyphosphate is predominantly
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Bhandari, R.; Saiardi, A.; Ahmadibeni, Y.; Snowman, A. M.; Resnick, A. C.; Kristiansen, T. Z.; Molina, H.; Pandey, A.; Werner, J. K.; Juluri, K. R.; Xu, Y.; Prestwich, G. D.; Parang, K.; Snyder, S. H. (2007).
98:, Hyderabad. Bhandari is pursuing her study on signal transduction in biological systems, with particular emphasis on understanding the role of inositol pyrophosphates in physiology and metabolism.
287:; Kim, Yong-Sung; Olsen, Mark J.; Bhandari, Rashna; Wittrup, K.Dane (2004). "Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments".
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on signal transduction by the membrane-bound guanylyl cyclase, GCC, which is involved in maintaining fluid and ion homeostasis across the intestinal membrane.
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Saiardi, A.; Bhandari, R; Resnick, A. C.; Snowman, A. M.; Snyder, S. H. (2004). "Phosphorylation of
Proteins by Inositol Pyrophosphates".
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Chen, X.; Bhandari, R; Vinkemeier, U; Van Den Akker, F; Darnell Jr, J. E.; Kuriyan, J (2003).
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on deciphering the role of inositol pyrophosphates as signalling molecules.
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Bhandari obtained her bachelor's degree in Human
Biology from the
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Bhandari believes that ambition leads to success and not gender.
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Biological
Sciences, Eukaryotic signal transduction
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237:Proceedings of the National Academy of Sciences
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160:. In 2003, Bhandari relocated to the
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420:Mallikarjun, Y. (18 February 2015).
164:in Baltimore, where she worked with
146:University of California, Berkeley
55:University of California, Berkeley
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489:Scientists from Hyderabad, India
374:"CDFD Profile - Rashna Bhandari"
289:Journal of Immunological Methods
162:Johns Hopkins School of Medicine
47:Johns Hopkins School of Medicine
484:20th-century Indian biologists
126:in 2008 as a Staff Scientist.
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131:Indian Institute of Science
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43:Indian Institute of Science
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133:, Bhandari worked with
129:Post her doctorate at
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285:Cochran, Jennifer R.
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243:(39): 15305–15310.
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