243:(Meng et al, Cell Reports 2021) and Delta variants with efficient ability to fuse cells (Mlcochova et al, Nature 2021), and the tropism shift and immune escape of Omicron (Meng et al, Nature 2022). These observations have translated to the clinic, reflecting disease severity of Delta versus Omicron and critically aiding public health policy regarding newly emerging variants at global scale. His work on COVID-19 vaccine induced immunity in older and immune suppressed persons has also been internationally recognised.
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WHO treatment guidelines for HIV, with recommendation for use of integrate inhibitors as first line core drugs. Gupta also reported the problem of tenofovir resistance in low-middle income settings and defined its emergence and characteristics through establishing the TenoRes collaboration with Bob Shafer at
Stanford (Gregson et al, Lancet Infectious diseases 2016; Gregson et al, Lancet Infectious diseases 2017).
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Gupta's group reported the first evidence for immune escape and infectivity enhancement of SARS-CoV-2 within host, thus also defining the process by which new variants likely arise in immune compromised individuals (Kemp et al, Nature 2021). Follow up work defined the replication advantages of Alpha
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Gupta researches HIV, from basic science of how the virus interacts with human cells and the immune system to the emerging problem of drug resistant HIV. More recently he has worked on COVID-19 rapid diagnostics, SARS-CoV-2 intra host evolution, replication, cell tropism and entry, as well as evasion
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During his time working on HIV reservoirs, he discovered why macrophages are infected in vivo by revealing cell cycle transitions in macrophages that radically changed virus susceptibility via SAMHD1 and availability of dNTP for reverse transcription (Mlcochova et al, EMBO J 2016). In March 2019 it
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Gupta has worked in HIV drug resistance both at molecular and population levels, and his work showing exponential rises in transmitted HIV resistance in Africa through multi-country collaborations alongside WHO (Gupta et al, Lancet 2012, Gupta et al, Lancet
Infectious Diseases 2018) led to change in
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remained "cured" of his HIV. This is the second case of a patient cured of HIV (Gupta et al, Nature 2019, Gupta et al, Lancet HIV 2020). The first patient is referred to as
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Gupta was formerly Full
Professor at University College London (2016-2019). He is head of the Gupta Lab and was supported by Wellcome Trust Fellowships from 2007 to 2023.
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Dissecting the biology of macrophage-virus interactions and the role of cell cycle given myeloid cells are parasitised by HIV and are a difficult-to-treat reservoir.
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from 1987 to 1994. Gupta gained his undergraduate medical degree from
Cambridge University in 1997 and then clinical degree from
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is a professor of clinical microbiology at the
Cambridge Institute of Therapeutic Immunology and Infectious Disease at the
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SARS-CoV-2 evolutionary biology and chronic COVID-19 infection in immune suppressed individuals
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Gupta's HIV-1 work spans the UK and sub
Saharan Africa. The lab focuses on four main areas:
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451:"H.I.V. Is Reported Cured in a Second Patient, a Milestone in the Global AIDS Epidemic"
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HIV drug resistance and implications for global scale up of antiretroviral therapy.
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165:(1998-1999). He subsequently trained in infectious diseases in Oxford and
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Cambridge
Institute of Therapeutic Immunology & Infectious Disease
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was reported that Gupta led a team demonstrating HIV remission in a
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This United
Kingdom biographical article related to medicine is a
228:. After a bone marrow transplant from an HIV-resistant donor, the
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261:"Ravindra Gupta: The 100 Most Influential People of 2020"
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in 2001, whilst completing a Master in Public Health at
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Immune responses to COVID-19 vaccination in risk groups
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163:Harvard School of Public Health
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477:Kelland, Kate (3 July 2020).
519:. You can help Knowledge by
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