192:, and air-flow, thereby encouraging academic institutions to test accuracy and precision in new ways. A few years later in the decade, battery-operated systems made debuts. For example, a demonstration of the mobile system with digital display of both cumulative and past-minute oxygen consumption was presented in 1977 at the Proceedings of the Physiological Society. As manufacturing and computing costs dropped over the next few decades, various universal calibration methods for preparing and comparing various models in the 1990s brought attention to short-comings or advantages of various designs. In addition to lower costs, the metabolic variable CO
170:
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accurate method for estimating the major portion of Total daily energy expenditure (TEE), thereby giving the closest approximations when planning & following a
Calorie Intake Plan. Thus, estimation of REE by indirect calorimetry is strongly recommended for accomplishing long-term weight management, a conclusion reached and maintained due to ongoing observational research by well-respected institutions such as the
159:
being volume/time, excluded urinary nitrogen, and allowed for the inclusion of a time conversion factor of 1.44 to extrapolate to 24-hour energy expenditure from 'kcal per minute" to "kcal per day." Weir used the
Douglas Bag method in his experiments, and in support of neglecting the effect of protein metabolism under normal physiological conditions and eating patterns of ~12.5% protein calories, he wrote:
944:
217:, most publications documented specific conditions of resting measurements, including time from latest food intake or physical activities; this comprehensive review estimated RMR is 10 – 20% higher than BMR due to thermic effect of feeding and residual burn from activities that occur throughout the day.
262:
Further, the correct use of a well-maintained indirect calorimeter includes achieving a natural and steady breathing pattern in order to reveal oxygen consumption and carbon dioxide production rates under a reproducible resting condition. Indirect calorimetry is considered the gold-standard method to
158:
To estimate energy expenditure from the exhaled gases, several algorithms were developed. One of the most widely used was developed in 1949 at
University of Glasgow by research physiologist J. B. de V. Weir. His abbreviated equation for estimating metabolic rate was written with rates of gas exchange
54:
because BMR measurements must meet total physiological equilibrium whereas RMR conditions of measurement can be altered and defined by the contextual limitations. Therefore, BMR is measured in the elusive "perfect" steady state, whereas RMR measurement is more accessible and thus, represents most, if
271:
Long-term weight management is directly proportional to calories absorbed from feeding; nevertheless, myriad non-caloric factors also play biologically significant roles (not covered here) in estimating energy intake. In counting energy expenditure, the use of a resting measurement (RMR) is the most
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by definition have a negative impact on their hosts and it is thus expected that there might be effects on host RMR. Varying effects of parasite infection on host RMR have been found. Most studies indicate an increase in RMR with parasite infection, but others show no effect, or even a decrease in
92:
A comprehensive treatment of confounding factors on BMR measurements is demonstrated as early as 1922 in
Massachusetts by Engineering Professor Frank B Sanborn, wherein descriptions of the effects of food, posture, sleep, muscular activity, and emotion provide criteria for separating BMR from RMR.
154:
In the early 20th century at Oxford
University, physiology researcher Claude Gordon Douglas developed an inexpensive and mobile method of collecting exhaled breath (partly in preparation for experiments to be conducted on Pike's Peak, Colorado). In this method, the subject exhales into a nearly
256:
For 30 minutes before conducting the measurement, a subject should be laying supine without physical movements, no reading nor listening to music. The ambiance should reduce stimulation by maintaining constant quiet, low lighting, and steady temperature. These conditions continue during the
155:
impermeable and large volume collection bag over a recorded period of time. The entire volume is measured, the oxygen and carbon dioxide content are analyzed, and the differences from inspired "ambient" air are calculated to determine the rates of oxygen uptake and carbon dioxide output.
85:. For example, following analysis of oxygen consumption of a human subject, if 5.5 kilocalories of energy were estimated during a 5-minute measurement from a rested individual, then the resting metabolic rate equals = 1.1 kcal/min rate. Unlike some related measurements (e.g.
244:(AND) provides clinical guidance for preparing a subject for RMR measures, in order to mitigate possible confounding factors from feeding, stressful physical activities, or exposure to stimulants such as caffeine or nicotine:
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was often ignored, promoting instead a focus on oxygen-consumption models of weight management and exercise training. In the new millennium, smaller "desktop-sized" indirect calorimeters were being distributed with dedicated
150:
of free-living humans. The work of
Atwater and Rosa also made it possible to calculate the caloric values of foods, which eventually became the criteria adopted by the USDA to create the food calorie library.
296:
Age: Besides the epidemiologically correlated trends of aging, lowered physical activity, and loss of lean muscle mass, lessened cellular activity (the senescence thereof) may also contribute to lowering of
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In preparation, a subject should be fasting for 7 hrs or greater, and mindful to avoid stimulants and stressors, such as caffeine, nicotine, and hard physical activities such as purposeful exercises.
213:
measures are restricted to the narrow time frame (and strict conditions) upon waking, the looser-conditions RMR measure is more typically conducted. In the review organized by the
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measure RMR. Indirect calorimeters are usually found in laboratory and clinical settings, but technological advancements are bringing RMR measurement to free-living conditions.
412:
Speakman, J.R., Krol, E., Johnson, M.S. 2004. The
Functional Significance of Individual Variation in Basal Metabolic Rate. Phys. Biochem. Zool. Vol. 77(6):900–915.
767:
184:
In the early 1970s, computer technology enabled on-site data processing, some real-time analysis, and even graphical displays of metabolic variables, such as O
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Thermochemistry aside, the rate of metabolism and an amount of energy expenditures can be mistakenly interchanged, for example, when describing RMR and REE.
424:
Report of preliminary investigations on the metabolism of nitrogen and carbon in the human organism, with a respiration calorimeter of special construction
912:
Robar, Nicholas; Murray, Dennis L.; Burness, Gary (2011). "Effects of parasites on host energy expenditure: the resting metabolic rate stalemate".
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790:
760:"Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients) (2005)"
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Beaver, WL; Wasserman, K; Whipp, BJ (1973). "On-line computer analysis and breath-by-breath graphical display of exercise function tests".
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241:
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gas exchanges from mammalian subjects. 100 years later in the 19th century for the
Connecticut-based Wesleyan University, Professors
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Wilmore, JH; Davis, JA; Norton, AC (1976). "An automated system for assessing metabolic and respiratory function during exercise".
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879:
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McNab, B. K. 1997. On the
Utility of Uniformity in the Definition of Basal Rate of Metabolism. Physiol. Zool. Vol.70; 718–720.
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Haugen, Heather A.; Chan, Lingtak-Neander; Li, Fanny (2007-08-01). "Indirect calorimetry: a practical guide for clinicians".
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791:"Position of the Academy of Nutrition and Dietetics: Interventions for the Treatment of Overweight and Obesity in Adults"
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47:
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332:"Twenty-four-hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects"
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RMR. It is still unclear why such variation in the direction of change in RMR with parasite infection is seen.
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RMR is regularly used in ecology to study the response of individuals to changes in environmental conditions.
167:
the percentage of protein calories lies between 10 and 14 the maximum error in using is less than 1 in 500."
447:
Description of a New
Respiration Calorimeter and Experiments on the Conservation of Energy in the Human Body
89:), RMR itself is not referenced to body mass and has no bearing on the energy density of the metabolism.
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766:. National Academy of Sciences, Institute of Medicine, Food and Nutrition Board. Archived from
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of amino acids, glucose, and fatty acids in human subjects, further establishing the value of
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RMR measurements are recommended when estimating total daily energy expenditure (TEE). Since
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Energy expenditure is correlated to a number of factors, listed in alphabetical order.
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732:"Angeion 2005 Annual Report -- page 7 -- Narrative Description of Business -- General"
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provided ample evidence of nitrogen, carbon dioxide, and oxygen transport during the
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685:"A respiratory gas exchange simulator for routine calibration in metabolic studies"
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An overview of how oxygen and carbon dioxide relate to human energy expenditure
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is transformed to rates of energy expenditure, expressed as the ratio between
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of oxygen consumption, sometimes carbon dioxide production, and less often
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Cunningham, D. J. C. (1964-11-01). "Claude Gordon Douglas. 1882-1963".
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Ravussin, E.; Burnand, B.; Schutz, Y.; Jéquier, E. (March 1, 1982).
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that are defined by a combination of assumptions of physiological
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Common correlates to metabolic rate and 24-hr energy expenditure
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not all measurements or estimates of daily energy expenditure.
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Clinical guidelines for conditions of resting measurements
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and printers, and running modern windows-based software.
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is the study or clinical use of the relationship between
884:(2 ed.). United States of America: Human Kinetics.
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Manore, Melinda; Meyer, Nanna; Thompson, Janice (2009).
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investigated and published relationships between direct
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Biographical Memoirs of Fellows of the Royal Society
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Basal metabolism: its determination and application
795:Journal of the Academy of Nutrition and Dietetics
106:In the 1780s for the French Academy of Sciences,
656:Humphrey, SJE; Wolff, HS (1977). "The Oxylog".
34:) is whole-body mammal (and other vertebrate)
789:Raynor, Hollie; Champagne, Catherine (2016).
683:Huszczuk, A; Whipp, BJ; Wasserman, K (1990).
8:
881:Sport Nutrition for Health and Performance
450:. Washington : Govt. print. off. 1899
427:. Washington : Govt. Print. Off. 1897
336:The American Journal of Clinical Nutrition
38:during a time period of strict and steady
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83:ii) the time frame of the measurement
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242:Academy of Nutrition and Dietetics
25:
457:– via The Internet Archive.
434:– via The Internet Archive.
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267:Use of REE in weight management
180:Computer-aided RMR measurements
69:, where the measurement of the
837:Nutrition in Clinical Practice
670:10.1113/jphysiol.1977.sp011841
555:10.1113/jphysiol.1949.sp004363
379:Sanborn M.S., Frank B (1922).
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623:Journal of Applied Physiology
588:Journal of Applied Physiology
280:, and internationally by the
221:Relationship between resting
704:10.1183/09031936.93.03040465
692:European Respiratory Journal
914:Canadian Journal of Zoology
849:10.1177/0115426507022004377
635:10.1152/jappl.1976.40.4.619
600:10.1152/jappl.1973.34.1.128
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807:10.1016/j.jand.2015.10.031
537:Weir, J. B. de V. (1949).
52:basal metabolic rate (BMR)
18:Resting energy expenditure
543:The Journal of Physiology
302:Work on non-human species
102:Pre-computer technologies
276:, AND (previously ADA),
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949:Resting metabolic rate
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48:biological equilibrium
28:Resting metabolic rate
658:Journal of Physiology
349:10.1093/ajcn/35.3.566
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951:at Wikimedia Commons
143:indirect calorimetry
97:Indirect calorimetry
59:Indirect calorimetry
50:. RMR differs from
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470:Why Calories Count
257:measurement stage.
227:energy expenditure
199:personal computers
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947:Media related to
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